FEM1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an ankyrin repeat protein that belongs to the death receptor-associated family of proteins and plays a role in mediating apoptosis. The encoded protein is also thought to function in the replication stress-induced checkpoint signaling pathway via interaction with checkpoint kinase 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)4.69490534
2nuclear pore complex assembly (GO:0051292)4.26450649
3nuclear pore organization (GO:0006999)4.16074404
4layer formation in cerebral cortex (GO:0021819)4.07924194
5negative regulation of histone methylation (GO:0031061)3.79661260
6regulation of gene silencing by RNA (GO:0060966)3.62871934
7regulation of posttranscriptional gene silencing (GO:0060147)3.62871934
8regulation of gene silencing by miRNA (GO:0060964)3.62871934
9regulation of short-term neuronal synaptic plasticity (GO:0048172)3.49718886
10mitotic sister chromatid cohesion (GO:0007064)3.41641318
11regulation of centriole replication (GO:0046599)3.37603141
12peptidyl-arginine methylation (GO:0018216)3.31745181
13peptidyl-arginine N-methylation (GO:0035246)3.31745181
14regulation of histone H3-K9 methylation (GO:0051570)3.31440798
15synaptic vesicle maturation (GO:0016188)3.27041720
16peptidyl-arginine omega-N-methylation (GO:0035247)3.24966292
17DNA replication-dependent nucleosome organization (GO:0034723)3.23065882
18DNA replication-dependent nucleosome assembly (GO:0006335)3.23065882
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.20031863
20regulation of RNA export from nucleus (GO:0046831)3.11284005
21cell communication by electrical coupling (GO:0010644)3.07234559
22Notch signaling involved in heart development (GO:0061314)3.06892824
23dendritic spine morphogenesis (GO:0060997)3.06000815
24regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.02095475
25locomotory exploration behavior (GO:0035641)3.01248743
26DNA unwinding involved in DNA replication (GO:0006268)3.00608067
27negative regulation of organelle assembly (GO:1902116)3.00357329
28cell migration in hindbrain (GO:0021535)2.92155245
29pore complex assembly (GO:0046931)2.89244672
30establishment of nucleus localization (GO:0040023)2.88274927
31sister chromatid segregation (GO:0000819)2.88054201
32histone H2A monoubiquitination (GO:0035518)2.87393183
33peptidyl-lysine dimethylation (GO:0018027)2.86874915
34coronary vasculature morphogenesis (GO:0060977)2.85219720
35histone arginine methylation (GO:0034969)2.82575831
36protein localization to kinetochore (GO:0034501)2.81069111
37negative regulation of DNA repair (GO:0045738)2.80898571
38NLS-bearing protein import into nucleus (GO:0006607)2.80657382
39apical protein localization (GO:0045176)2.77448501
40regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.76345036
41embryonic process involved in female pregnancy (GO:0060136)2.75028385
42adherens junction assembly (GO:0034333)2.74408942
43nerve growth factor signaling pathway (GO:0038180)2.74369120
44cardiac muscle hypertrophy in response to stress (GO:0014898)2.74344237
45muscle hypertrophy in response to stress (GO:0003299)2.74344237
46cardiac muscle adaptation (GO:0014887)2.74344237
47regulation of translational termination (GO:0006449)2.71973531
48sodium ion export (GO:0071436)2.70353698
49regulation of transforming growth factor beta2 production (GO:0032909)2.66671886
50regulation of sister chromatid cohesion (GO:0007063)2.66664134
51vocalization behavior (GO:0071625)2.65760465
52focal adhesion assembly (GO:0048041)2.65321814
53cell-substrate adherens junction assembly (GO:0007045)2.65321814
54morphogenesis of an epithelial sheet (GO:0002011)2.64938558
55regulation of synaptic vesicle exocytosis (GO:2000300)2.64685835
56cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.64508393
57axonal fasciculation (GO:0007413)2.63716595
58negative regulation of dendrite morphogenesis (GO:0050774)2.63471090
59cytoplasmic mRNA processing body assembly (GO:0033962)2.63133581
60monoubiquitinated protein deubiquitination (GO:0035520)2.61718652
61positive regulation of dendritic spine morphogenesis (GO:0061003)2.61612644
62cardiac muscle hypertrophy (GO:0003300)2.61011568
63peptidyl-threonine modification (GO:0018210)2.60938502
64glutamate secretion (GO:0014047)2.58950007
65nuclear envelope disassembly (GO:0051081)2.58939480
66membrane disassembly (GO:0030397)2.58939480
67synaptic vesicle docking involved in exocytosis (GO:0016081)2.58435269
68negative regulation of histone modification (GO:0031057)2.58274807
69chromatin assembly (GO:0031497)2.58138292
70paraxial mesoderm development (GO:0048339)2.57974328
71peptidyl-threonine phosphorylation (GO:0018107)2.57853616
72cellular protein complex localization (GO:0034629)2.57171207
73regulation of cAMP-dependent protein kinase activity (GO:2000479)2.56784869
74stress granule assembly (GO:0034063)2.56048776
75exploration behavior (GO:0035640)2.55485010
76positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.55376236
77cell communication involved in cardiac conduction (GO:0086065)2.54742848
78regulation of translational fidelity (GO:0006450)2.54741735
79positive regulation of synapse maturation (GO:0090129)2.54265674
80negative regulation of microtubule polymerization (GO:0031115)2.53848238
81protein localization to endosome (GO:0036010)2.53712346
82regulation of nucleobase-containing compound transport (GO:0032239)2.53488022
83spliceosomal tri-snRNP complex assembly (GO:0000244)2.52817883
84regulation of centrosome duplication (GO:0010824)2.52535094
85synaptic vesicle exocytosis (GO:0016079)2.52372022
86positive regulation of catenin import into nucleus (GO:0035413)2.52291141
87positive regulation of mitotic sister chromatid separation (GO:1901970)2.49609540
88positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.49609540
89positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.49609540
90spindle assembly involved in mitosis (GO:0090307)2.48821041
91regulation of centrosome cycle (GO:0046605)2.48573206
92negative regulation of neurotransmitter secretion (GO:0046929)2.48536549
93mitotic nuclear envelope disassembly (GO:0007077)2.48424973
94negative regulation of chromatin modification (GO:1903309)2.47768406
95striated muscle hypertrophy (GO:0014897)2.47427171
96neuron cell-cell adhesion (GO:0007158)2.45760877
97vesicle transport along microtubule (GO:0047496)2.45603715
98regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.45234152
99polarized epithelial cell differentiation (GO:0030859)2.44831731
100desmosome organization (GO:0002934)2.44778015
101hippo signaling (GO:0035329)2.44069032
102neuron recognition (GO:0008038)2.43883876
103establishment or maintenance of monopolar cell polarity (GO:0061339)2.43819724
104establishment of monopolar cell polarity (GO:0061162)2.43819724
105heterochromatin organization (GO:0070828)2.43802560
106gastrulation with mouth forming second (GO:0001702)2.42851643
107negative regulation of smooth muscle cell differentiation (GO:0051151)2.42070316
108protein localization to synapse (GO:0035418)2.40949459
109axon extension (GO:0048675)2.40439045
110protein localization to chromosome, centromeric region (GO:0071459)2.39888376
111embryonic camera-type eye morphogenesis (GO:0048596)2.39850852
112nucleus localization (GO:0051647)2.39705058
113anterior/posterior axis specification, embryo (GO:0008595)2.39527607
114regulation of telomere maintenance via telomerase (GO:0032210)2.39299417
115positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.38669770
116ectodermal placode formation (GO:0060788)2.38246406
117microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.37994881
118regulation of clathrin-mediated endocytosis (GO:2000369)2.37185213
119microtubule depolymerization (GO:0007019)2.36306454
120dendrite morphogenesis (GO:0048813)2.36025416
121mitotic chromosome condensation (GO:0007076)2.35849050
122cerebral cortex development (GO:0021987)2.35273347
123positive regulation of chromosome segregation (GO:0051984)2.35167810
124regulation of hippo signaling (GO:0035330)2.35084691
125mitotic sister chromatid segregation (GO:0000070)2.34901019
126cardiac myofibril assembly (GO:0055003)2.34348495
127presynaptic membrane assembly (GO:0097105)2.34139084
128clathrin coat assembly (GO:0048268)2.34057833
129regulation of glutamate receptor signaling pathway (GO:1900449)2.33909992
130central nervous system projection neuron axonogenesis (GO:0021952)2.33356727
131regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.33202936
132proline transport (GO:0015824)2.32959583
133organelle transport along microtubule (GO:0072384)2.32251792
134cerebellar Purkinje cell differentiation (GO:0021702)2.30996272
135glucocorticoid receptor signaling pathway (GO:0042921)2.30849589
136myotube differentiation (GO:0014902)2.30682998
137regulation of NFAT protein import into nucleus (GO:0051532)2.30046969
138cytoskeletal anchoring at plasma membrane (GO:0007016)2.30043035
139negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.29476195
140cell surface receptor signaling pathway involved in heart development (GO:0061311)2.28740359
141protein complex localization (GO:0031503)2.28370428
142asymmetric protein localization (GO:0008105)2.27123558
143positive regulation of p38MAPK cascade (GO:1900745)2.27048312
144cell-substrate junction assembly (GO:0007044)2.26274186
145corticosteroid receptor signaling pathway (GO:0031958)2.25402872
146regulation of cardioblast differentiation (GO:0051890)2.22488889
147neuron projection extension (GO:1990138)2.22176668
148regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.20492962
149phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.19338529
150cerebellar granule cell differentiation (GO:0021707)2.19093263
151neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.18612092
152cardiac right ventricle morphogenesis (GO:0003215)2.18590417
153cellular potassium ion homeostasis (GO:0030007)2.16974123
154positive regulation of SMAD protein import into nucleus (GO:0060391)2.16885912
155presynaptic membrane organization (GO:0097090)2.15444797
156neuromuscular process controlling balance (GO:0050885)2.15178725
157chondrocyte development (GO:0002063)2.14360049
158negative regulation of dendrite development (GO:2000171)2.11611336
159negative regulation of fibroblast apoptotic process (GO:2000270)2.11125405
160positive regulation of cardiac muscle cell proliferation (GO:0060045)2.08978225
161atrial cardiac muscle cell action potential (GO:0086014)2.08970060
162negative regulation of vascular permeability (GO:0043116)2.08209586
163embryonic foregut morphogenesis (GO:0048617)2.07988417
164cardiac cell development (GO:0055006)2.07537207
165positive regulation of heart growth (GO:0060421)2.07435299
166protein localization to microtubule (GO:0035372)2.06471776
167regulation of catenin import into nucleus (GO:0035412)2.04877560
168membrane assembly (GO:0071709)2.04414300
169regulation of early endosome to late endosome transport (GO:2000641)2.04301971
170negative regulation of potassium ion transmembrane transport (GO:1901380)2.04011235
171developmental cell growth (GO:0048588)2.03862880
172histone H3-K9 demethylation (GO:0033169)2.03566598
173positive regulation of cardiac muscle tissue growth (GO:0055023)2.03465468
174regulation of Rac protein signal transduction (GO:0035020)2.03058751

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.35248561
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.74935581
3SALL1_21062744_ChIP-ChIP_HESCs_Human4.01836531
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.55606823
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.29957568
6EZH2_22144423_ChIP-Seq_EOC_Human3.05822345
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.87503914
8KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.84332768
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.55994343
10WT1_19549856_ChIP-ChIP_CCG9911_Human2.54287412
11* SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.48410012
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.35013687
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.32450028
14ZNF217_24962896_ChIP-Seq_MCF-7_Human2.25871947
15ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.19570111
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.16587612
17* TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.10549930
18SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.08867279
19ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.08362327
20SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.97800783
21HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.95963297
22EGR1_19374776_ChIP-ChIP_THP-1_Human1.95041835
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.86714460
24EP300_21415370_ChIP-Seq_HL-1_Mouse1.78222399
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.74685894
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.74472720
27ZFP281_18757296_ChIP-ChIP_E14_Mouse1.72020283
28ZNF274_21170338_ChIP-Seq_K562_Hela1.66617715
29ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.66128133
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64837261
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.63201510
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.62807119
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60402139
34OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59023455
35ZFP281_27345836_Chip-Seq_ESCs_Mouse1.57383630
36NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.57180948
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.55059988
38* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54400345
39NRF2_20460467_ChIP-Seq_MEFs_Mouse1.53955799
40NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.53955799
41SOX2_18555785_ChIP-Seq_MESCs_Mouse1.53945274
42FUS_26573619_Chip-Seq_HEK293_Human1.53142939
43NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.52184641
44POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.51251195
45TAF15_26573619_Chip-Seq_HEK293_Human1.50695493
46ESR1_15608294_ChIP-ChIP_MCF-7_Human1.50477200
47GATA1_22025678_ChIP-Seq_K562_Human1.49714575
48REST_21632747_ChIP-Seq_MESCs_Mouse1.49126156
49* RARB_27405468_Chip-Seq_BRAIN_Mouse1.48245396
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48096902
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46217937
52CTNNB1_20460455_ChIP-Seq_HCT116_Human1.44452368
53SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.43284370
54NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.42853367
55TP53_16413492_ChIP-PET_HCT116_Human1.41891472
56* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.41780268
57PKCTHETA_26484144_Chip-Seq_BREAST_Human1.40334012
58* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.40082971
59AR_21572438_ChIP-Seq_LNCaP_Human1.39576759
60* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.37253450
61RNF2_18974828_ChIP-Seq_MESCs_Mouse1.37226619
62EZH2_18974828_ChIP-Seq_MESCs_Mouse1.37226619
63NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37226020
64GBX2_23144817_ChIP-Seq_PC3_Human1.36957897
65* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.36763134
66SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.36151180
67AHR_22903824_ChIP-Seq_MCF-7_Human1.35063649
68CLOCK_20551151_ChIP-Seq_293T_Human1.33387571
69SOX2_16153702_ChIP-ChIP_HESCs_Human1.30857692
70TP53_18474530_ChIP-ChIP_U2OS_Human1.30518078
71* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30157862
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29771192
73DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.29693402
74PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.28773846
75CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.28628393
76NANOG_21062744_ChIP-ChIP_HESCs_Human1.27089666
77* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.26891601
78CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25367837
79NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.24768879
80SOX9_24532713_ChIP-Seq_HFSC_Mouse1.24731089
81TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23977884
82HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23932579
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23681690
84FOXM1_26456572_ChIP-Seq_MCF-7_Human1.23380023
85ARNT_22903824_ChIP-Seq_MCF-7_Human1.23344549
86E2F1_21310950_ChIP-Seq_MCF-7_Human1.23221749
87FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.23131292
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21869942
89JARID2_20064375_ChIP-Seq_MESCs_Mouse1.20651867
90TBX3_20139965_ChIP-Seq_ESCs_Mouse1.20496001
91CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.20360325
92TBX3_20139965_ChIP-Seq_MESCs_Mouse1.19832377
93* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.19121593
94YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18488513
95P300_19829295_ChIP-Seq_ESCs_Human1.18207915
96* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17923735
97SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.17740436
98* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.17516113
99EZH2_27304074_Chip-Seq_ESCs_Mouse1.16956365
100SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.14336744
101RNF2_27304074_Chip-Seq_ESCs_Mouse1.14038274
102KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.13634145
103KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.13634145
104KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.13634145
105WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13069739
106TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12658150
107POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12658150
108LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12257095
109SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.12015551
110GF1B_26923725_Chip-Seq_HPCs_Mouse1.10693491
111TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09981871
112RNF2_27304074_Chip-Seq_NSC_Mouse1.08631847
113REST_18959480_ChIP-ChIP_MESCs_Mouse1.07939647
114STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07549208
115SMAD3_21741376_ChIP-Seq_HESCs_Human1.05566078
116RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05292022
117AR_21909140_ChIP-Seq_LNCAP_Human1.04999043
118CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04241217
119* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03334659
120GATA1_26923725_Chip-Seq_HPCs_Mouse1.02839842
121* FOXO3_23340844_ChIP-Seq_DLD1_Human1.01839420
122TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01674760
123POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01325682
124NANOG_18555785_Chip-Seq_ESCs_Mouse1.00559536
125EWS_26573619_Chip-Seq_HEK293_Human0.99538452
126MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99440703
127MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98985346
128RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98868057
129* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.98743629
130POU5F1_16518401_ChIP-PET_MESCs_Mouse0.97642808
131CBX2_27304074_Chip-Seq_ESCs_Mouse0.97192427
132POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.97178220
133PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.97062325
134MYCN_18555785_ChIP-Seq_MESCs_Mouse0.96894012
135MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.96185764
136CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96024666
137FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.95396008
138ISL1_27105846_Chip-Seq_CPCs_Mouse0.94622092
139RING1B_27294783_Chip-Seq_NPCs_Mouse0.93865443
140MYC_18555785_ChIP-Seq_MESCs_Mouse0.93773436
141SOX2_21211035_ChIP-Seq_LN229_Gbm0.93083090
142POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92881254
143* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.92204330
144NANOG_16518401_ChIP-PET_MESCs_Mouse0.91773282
145STAT6_21828071_ChIP-Seq_BEAS2B_Human0.90599875
146AR_19668381_ChIP-Seq_PC3_Human0.90380209
147SOX9_26525672_Chip-Seq_HEART_Mouse0.90014864
148RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.89537310
149STAT3_23295773_ChIP-Seq_U87_Human0.89470726
150CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87955698
151* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.85854974
152* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.85340043
153ZNF263_19887448_ChIP-Seq_K562_Human0.85086774
154* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.85034663
155SMAD3_21741376_ChIP-Seq_ESCs_Human0.85033085
156SMAD3_21741376_ChIP-Seq_EPCs_Human0.84690258
157* SMAD4_21799915_ChIP-Seq_A2780_Human0.84168065
158DROSHA_22980978_ChIP-Seq_HELA_Human0.82913565

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003123_paternal_imprinting3.12772111
2MP0004859_abnormal_synaptic_plasticity3.10106533
3MP0003121_genomic_imprinting2.59092472
4MP0000569_abnormal_digit_pigmentation2.52629322
5MP0002009_preneoplasia2.50050701
6MP0003122_maternal_imprinting2.40711758
7MP0003787_abnormal_imprinting2.34028655
8MP0010234_abnormal_vibrissa_follicle2.28361267
9MP0003890_abnormal_embryonic-extraembry2.25417752
10MP0004270_analgesia2.24387045
11MP0005275_abnormal_skin_tensile2.17664423
12MP0003941_abnormal_skin_development2.15820202
13MP0002877_abnormal_melanocyte_morpholog2.07156470
14MP0000537_abnormal_urethra_morphology2.00608699
15MP0003635_abnormal_synaptic_transmissio1.96205869
16MP0000778_abnormal_nervous_system1.94893117
17MP0002653_abnormal_ependyma_morphology1.92419633
18MP0005409_darkened_coat_color1.91685954
19MP0000579_abnormal_nail_morphology1.84611489
20MP0003880_abnormal_central_pattern1.81192003
21MP0003119_abnormal_digestive_system1.78991254
22MP0005076_abnormal_cell_differentiation1.76954374
23MP0004272_abnormal_basement_membrane1.76508853
24MP0010352_gastrointestinal_tract_polyps1.73879050
25MP0003705_abnormal_hypodermis_morpholog1.73489679
26MP0002084_abnormal_developmental_patter1.71206556
27MP0002063_abnormal_learning/memory/cond1.68913178
28MP0008877_abnormal_DNA_methylation1.68266284
29MP0010094_abnormal_chromosome_stability1.66807498
30MP0005187_abnormal_penis_morphology1.66031626
31MP0002796_impaired_skin_barrier1.61345183
32MP0003861_abnormal_nervous_system1.59620989
33MP0005623_abnormal_meninges_morphology1.58311342
34MP0003111_abnormal_nucleus_morphology1.56945244
35MP0003566_abnormal_cell_adhesion1.56794274
36MP0005423_abnormal_somatic_nervous1.54422839
37MP0010678_abnormal_skin_adnexa1.53806468
38MP0003283_abnormal_digestive_organ1.49948314
39MP0010307_abnormal_tumor_latency1.49695797
40MP0003091_abnormal_cell_migration1.49612784
41MP0004233_abnormal_muscle_weight1.49418807
42MP0001730_embryonic_growth_arrest1.48617975
43MP0009780_abnormal_chondrocyte_physiolo1.48281501
44MP0004197_abnormal_fetal_growth/weight/1.47110504
45MP0009384_cardiac_valve_regurgitation1.45065041
46MP0000566_synostosis1.43043550
47MP0006072_abnormal_retinal_apoptosis1.42082735
48MP0008438_abnormal_cutaneous_collagen1.41565588
49MP0004811_abnormal_neuron_physiology1.40876706
50MP0004957_abnormal_blastocyst_morpholog1.40084868
51MP0002085_abnormal_embryonic_tissue1.40031810
52MP0002734_abnormal_mechanical_nocicepti1.37000893
53MP0000751_myopathy1.36621800
54MP0003077_abnormal_cell_cycle1.34959285
55MP0000462_abnormal_digestive_system1.34576478
56MP0002184_abnormal_innervation1.32901783
57MP0002152_abnormal_brain_morphology1.32329608
58MP0001293_anophthalmia1.31910356
59MP0003453_abnormal_keratinocyte_physiol1.30778243
60MP0000955_abnormal_spinal_cord1.29759181
61MP0001188_hyperpigmentation1.28894532
62MP0009046_muscle_twitch1.27605698
63MP0004858_abnormal_nervous_system1.27095156
64MP0001697_abnormal_embryo_size1.24892059
65MP0000350_abnormal_cell_proliferation1.23770502
66MP0001672_abnormal_embryogenesis/_devel1.22819485
67MP0005380_embryogenesis_phenotype1.22819485
68MP0009745_abnormal_behavioral_response1.22700315
69MP0003329_amyloid_beta_deposits1.20511866
70MP0005499_abnormal_olfactory_system1.19432851
71MP0005394_taste/olfaction_phenotype1.19432851
72MP0004885_abnormal_endolymph1.18773360
73MP0005257_abnormal_intraocular_pressure1.18391817
74MP0003937_abnormal_limbs/digits/tail_de1.17861985
75MP0002086_abnormal_extraembryonic_tissu1.17218515
76MP0001299_abnormal_eye_distance/1.17217999
77MP0002572_abnormal_emotion/affect_behav1.16337303
78MP0003221_abnormal_cardiomyocyte_apopto1.15695632
79MP0001177_atelectasis1.14737556
80MP0004133_heterotaxia1.12506395
81MP0003634_abnormal_glial_cell1.11507989
82MP0010030_abnormal_orbit_morphology1.11187390
83MP0005248_abnormal_Harderian_gland1.11054491
84MP0000383_abnormal_hair_follicle1.10789698
85MP0009053_abnormal_anal_canal1.10102957
86MP0002064_seizures1.09919865
87MP0002088_abnormal_embryonic_growth/wei1.09168543
88MP0003984_embryonic_growth_retardation1.08303836
89MP0002882_abnormal_neuron_morphology1.07011646
90MP0009703_decreased_birth_body1.06909712
91MP0000631_abnormal_neuroendocrine_gland1.06358506
92MP0004185_abnormal_adipocyte_glucose1.05884771
93MP0004087_abnormal_muscle_fiber1.03764093
94MP0001486_abnormal_startle_reflex1.03112465
95MP0000534_abnormal_ureter_morphology1.03006697
96MP0010630_abnormal_cardiac_muscle1.02058668
97MP0003690_abnormal_glial_cell1.01673293
98MP0000747_muscle_weakness1.01034187
99MP0001849_ear_inflammation1.00665244
100MP0003935_abnormal_craniofacial_develop1.00335918
101MP0002557_abnormal_social/conspecific_i1.00213419
102MP0003755_abnormal_palate_morphology0.99972693
103MP0001968_abnormal_touch/_nociception0.99046757
104MP0002697_abnormal_eye_size0.98259479
105MP0003693_abnormal_embryo_hatching0.97130567
106MP0002092_abnormal_eye_morphology0.96648402
107MP0002080_prenatal_lethality0.96646700
108MP0003385_abnormal_body_wall0.96631545
109MP0003115_abnormal_respiratory_system0.96588111
110MP0002081_perinatal_lethality0.96439287
111MP0003942_abnormal_urinary_system0.96161144
112MP0005171_absent_coat_pigmentation0.95394584
113MP0008789_abnormal_olfactory_epithelium0.94937759
114MP0003698_abnormal_male_reproductive0.91873487
115MP0008057_abnormal_DNA_replication0.91822609
116MP0009672_abnormal_birth_weight0.90578683
117MP0000749_muscle_degeneration0.90038438
118MP0002733_abnormal_thermal_nociception0.89259226
119MP0004264_abnormal_extraembryonic_tissu0.88799310
120MP0000428_abnormal_craniofacial_morphol0.88433561
121MP0001915_intracranial_hemorrhage0.88408997
122MP0002233_abnormal_nose_morphology0.87847854
123MP0004924_abnormal_behavior0.87802724
124MP0005386_behavior/neurological_phenoty0.87802724
125MP0000733_abnormal_muscle_development0.87626718
126MP0005410_abnormal_fertilization0.87489604
127MP0008569_lethality_at_weaning0.85754673
128MP0000516_abnormal_urinary_system0.85215286
129MP0005367_renal/urinary_system_phenotyp0.85215286
130MP0002909_abnormal_adrenal_gland0.84550181
131MP0003567_abnormal_fetal_cardiomyocyte0.83885091
132MP0002896_abnormal_bone_mineralization0.83716272
133MP0003828_pulmonary_edema0.83379615
134MP0002234_abnormal_pharynx_morphology0.82786433
135MP0002269_muscular_atrophy0.82589084
136MP0001286_abnormal_eye_development0.82588233
137MP0000432_abnormal_head_morphology0.82178312
138MP0008932_abnormal_embryonic_tissue0.80137705
139MP0003632_abnormal_nervous_system0.79165637
140MP0005197_abnormal_uvea_morphology0.78438339
141MP0002060_abnormal_skin_morphology0.78186619
142MP0001984_abnormal_olfaction0.77915199
143MP0000767_abnormal_smooth_muscle0.77807458
144MP0002108_abnormal_muscle_morphology0.77663463
145MP0005620_abnormal_muscle_contractility0.77272809
146MP0002925_abnormal_cardiovascular_devel0.76882713
147MP0004036_abnormal_muscle_relaxation0.76154796
148MP0001440_abnormal_grooming_behavior0.76119880
149MP0004084_abnormal_cardiac_muscle0.75751697
150MP0002090_abnormal_vision0.75130766

Predicted human phenotypes

RankGene SetZ-score
1Vertebral arch anomaly (HP:0008438)3.65690646
2Astrocytoma (HP:0009592)3.20090653
3Abnormality of the astrocytes (HP:0100707)3.20090653
4Abnormality of the labia minora (HP:0012880)3.06140773
5Ependymoma (HP:0002888)3.04576666
6Termporal pattern (HP:0011008)2.70973403
7Insidious onset (HP:0003587)2.70973403
8Abnormality of the lower motor neuron (HP:0002366)2.57383013
9Curly hair (HP:0002212)2.56554239
10Overgrowth (HP:0001548)2.50082365
11Cubitus valgus (HP:0002967)2.44608992
12Amyotrophic lateral sclerosis (HP:0007354)2.44334188
13Papillary thyroid carcinoma (HP:0002895)2.44065236
14Colon cancer (HP:0003003)2.39612636
15Glioma (HP:0009733)2.38691822
16Dysmetric saccades (HP:0000641)2.37658719
17Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.36825798
18Short 4th metacarpal (HP:0010044)2.36825798
19Medulloblastoma (HP:0002885)2.36580998
20Heterotopia (HP:0002282)2.33140697
21Shoulder girdle muscle weakness (HP:0003547)2.29097629
22Neoplasm of the oral cavity (HP:0100649)2.28707267
23Neurofibrillary tangles (HP:0002185)2.23888247
24Subacute progressive viral hepatitis (HP:0006572)2.20838677
25Visual hallucinations (HP:0002367)2.15822007
26Impaired vibration sensation in the lower limbs (HP:0002166)2.14776968
27Arterial tortuosity (HP:0005116)2.14731848
28Focal seizures (HP:0007359)2.13942575
29Renal duplication (HP:0000075)2.12803317
30Scanning speech (HP:0002168)2.12754476
31Asymmetry of the thorax (HP:0001555)2.12355489
32Volvulus (HP:0002580)2.07662519
33Aplasia involving bones of the extremities (HP:0009825)2.07619793
34Aplasia involving bones of the upper limbs (HP:0009823)2.07619793
35Aplasia of the phalanges of the hand (HP:0009802)2.07619793
36Macroorchidism (HP:0000053)2.05774044
37Inappropriate behavior (HP:0000719)2.05447905
38Urinary bladder sphincter dysfunction (HP:0002839)2.05343013
39Cerebral inclusion bodies (HP:0100314)2.04352423
40Impaired smooth pursuit (HP:0007772)2.02498830
41Pointed chin (HP:0000307)2.02136146
42Increased nuchal translucency (HP:0010880)2.01407542
43Tetraparesis (HP:0002273)2.00918393
44Hyperventilation (HP:0002883)2.00560938
45Drooling (HP:0002307)2.00279893
46Excessive salivation (HP:0003781)2.00279893
47Ankyloglossia (HP:0010296)1.99400827
48Hammertoe (HP:0001765)1.97657676
49Aqueductal stenosis (HP:0002410)1.97317670
50Hepatoblastoma (HP:0002884)1.96644242
51Abnormality of nail color (HP:0100643)1.96230408
52Pelvic girdle muscle weakness (HP:0003749)1.94722265
53Neoplasm of the adrenal cortex (HP:0100641)1.92984339
54Right ventricular cardiomyopathy (HP:0011663)1.92711638
55Thickened helices (HP:0000391)1.92645639
56Deep philtrum (HP:0002002)1.92433535
57Blue irides (HP:0000635)1.92090885
58Difficulty running (HP:0009046)1.91712786
59Germ cell neoplasia (HP:0100728)1.91069599
60Hyporeflexia of lower limbs (HP:0002600)1.90612540
61Rhabdomyosarcoma (HP:0002859)1.89150353
62Relative macrocephaly (HP:0004482)1.88857434
63Vascular tortuosity (HP:0004948)1.88428998
64Urinary urgency (HP:0000012)1.88153633
65Hyperacusis (HP:0010780)1.87783805
66Gastrointestinal carcinoma (HP:0002672)1.87567232
67Malignant gastrointestinal tract tumors (HP:0006749)1.87567232
68Cortical dysplasia (HP:0002539)1.86341762
69Progressive cerebellar ataxia (HP:0002073)1.85637626
70Abnormality of ocular smooth pursuit (HP:0000617)1.85561332
71Sacral dimple (HP:0000960)1.84854613
72Genetic anticipation (HP:0003743)1.84665266
73Abnormality of the corticospinal tract (HP:0002492)1.84571063
74Neoplasm of striated muscle (HP:0009728)1.82575174
75Long nose (HP:0003189)1.81730466
76Insomnia (HP:0100785)1.81425665
77High anterior hairline (HP:0009890)1.81415866
78Hypopigmentation of the fundus (HP:0007894)1.81391220
79Mitral valve prolapse (HP:0001634)1.81243733
80Absent frontal sinuses (HP:0002688)1.79777256
81Cutaneous syndactyly (HP:0012725)1.79543199
82Renovascular hypertension (HP:0100817)1.78372791
83Febrile seizures (HP:0002373)1.78157325
84Hypoplasia of the iris (HP:0007676)1.77774113
85Absent eyelashes (HP:0000561)1.76666676
86Pulmonic stenosis (HP:0001642)1.76526074
87Biliary tract neoplasm (HP:0100574)1.76449024
88Papilledema (HP:0001085)1.75889820
89Facial hemangioma (HP:0000329)1.75690749
90Protruding tongue (HP:0010808)1.75480459
91Resting tremor (HP:0002322)1.75309476
92Abnormality of abdominal situs (HP:0011620)1.75247254
93Abdominal situs inversus (HP:0003363)1.75247254
94Obsessive-compulsive behavior (HP:0000722)1.75124675
95Neonatal hypoglycemia (HP:0001998)1.74433453
96Abnormality of the left ventricular outflow tract (HP:0011103)1.73978934
97Subaortic stenosis (HP:0001682)1.73978934
98Cystic hygroma (HP:0000476)1.73614191
99Fibrous tissue neoplasm (HP:0012316)1.71438759
100Fair hair (HP:0002286)1.71308546
101Elfin facies (HP:0004428)1.71288995
102Transitional cell carcinoma of the bladder (HP:0006740)1.71227248
103Abnormality of the musculature of the pelvis (HP:0001469)1.70461394
104Abnormality of the hip-girdle musculature (HP:0001445)1.70461394
105Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.70362013
106Fibroma (HP:0010614)1.69725893
107Aplasia/Hypoplasia of the sternum (HP:0006714)1.69299971
108Intellectual disability, profound (HP:0002187)1.68304369
109Myokymia (HP:0002411)1.68071521
110Bladder neoplasm (HP:0009725)1.67620840
111Bladder carcinoma (HP:0002862)1.67620840
112Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.66859356
113Action tremor (HP:0002345)1.66794602
114Pheochromocytoma (HP:0002666)1.66517101
115Absent eyebrow (HP:0002223)1.66357488
116Atrophic scars (HP:0001075)1.66115427
117Depression (HP:0000716)1.65974470
118Truncal ataxia (HP:0002078)1.64617436
119Missing ribs (HP:0000921)1.63901492
120Turricephaly (HP:0000262)1.63848572
121Abnormality of the 4th metacarpal (HP:0010012)1.62801338
122Intestinal polyposis (HP:0200008)1.62413957
123Overriding aorta (HP:0002623)1.62347604
124Deeply set eye (HP:0000490)1.61907261
125Intestinal polyp (HP:0005266)1.61419541
126Cerebral aneurysm (HP:0004944)1.61312842
127Broad thumb (HP:0011304)1.61120279
128Megalocornea (HP:0000485)1.61092081
129Abnormality of the diencephalon (HP:0010662)1.60324115
130Abnormality of chromosome segregation (HP:0002916)1.59976625
131Leiomyosarcoma (HP:0100243)1.59739163
132Uterine leiomyosarcoma (HP:0002891)1.59739163
133Supernumerary spleens (HP:0009799)1.59437932
134Shawl scrotum (HP:0000049)1.59096352
135Thyroid carcinoma (HP:0002890)1.58373939
136Apathy (HP:0000741)1.58086339
137Cutaneous finger syndactyly (HP:0010554)1.57226962
138Lower limb amyotrophy (HP:0007210)1.56476984
139Epileptic encephalopathy (HP:0200134)1.56090682
140Atonic seizures (HP:0010819)1.55972209
141Abnormality of oral frenula (HP:0000190)1.55476227
142Truncal obesity (HP:0001956)1.55441868
143Sandal gap (HP:0001852)1.55179373
144Exotropia (HP:0000577)1.55106615
145Generalized hypopigmentation of hair (HP:0011358)1.55091776
146Bowel diverticulosis (HP:0005222)1.55061660
147Narrow palate (HP:0000189)1.54147248
148Lower limb muscle weakness (HP:0007340)1.53150537
149Syringomyelia (HP:0003396)1.52831899
150Spinal cord lesions (HP:0100561)1.52831899
151Mild short stature (HP:0003502)1.52619783
152Esophageal atresia (HP:0002032)1.52541605
153Focal motor seizures (HP:0011153)1.52272902
154Embryonal renal neoplasm (HP:0011794)1.51624154
155Adenoma sebaceum (HP:0009720)1.51002891
156Angiofibromas (HP:0010615)1.51002891
157Disinhibition (HP:0000734)1.50205067
158Bifid tongue (HP:0010297)1.50163303
159Abnormality of the axillary hair (HP:0100134)1.49700154
160Abnormality of secondary sexual hair (HP:0009888)1.49700154
161Nephroblastoma (Wilms tumor) (HP:0002667)1.49677631
162Short humerus (HP:0005792)1.48967152
163Large earlobe (HP:0009748)1.48886447
164Septate vagina (HP:0001153)1.48565255
165Gait ataxia (HP:0002066)1.48461530
166Impaired vibratory sensation (HP:0002495)1.44557986
167Skin pits (HP:0100276)1.44365279

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.62548389
2MAP3K92.85951378
3SCYL22.70625246
4STK242.67335775
5CDC72.58270336
6CASK2.56979480
7MAP3K42.49422558
8PNCK2.41630351
9TAF12.37949575
10NTRK32.25412293
11PRKD32.14278592
12LATS22.11710001
13NEK12.09164411
14CDK122.06059569
15KSR11.96441958
16LATS11.76547840
17MINK11.67043883
18SGK21.62901343
19PAK61.60682272
20PRPF4B1.60169436
21KSR21.57998215
22PKN21.56975902
23NTRK21.53223983
24ALK1.48376611
25SGK31.44236101
26PLK31.38738173
27ERBB31.34801979
28SGK2231.27700973
29SGK4941.27700973
30EEF2K1.25870691
31TYRO31.22985767
32MAP3K21.22174839
33WEE11.21828699
34DMPK1.21709424
35NEK21.20953435
36MKNK21.20612380
37EPHA41.20082871
38YES11.18372788
39PLK21.17976487
40TNIK1.14927923
41PDK31.12023788
42PDK41.12023788
43STK38L1.08939281
44FGFR31.08829764
45CHEK21.08038418
46ICK1.05607257
47TTN1.03443320
48RAF11.02361851
49SRPK11.01317920
50PASK0.99332020
51WNK30.97447265
52AKT30.96946953
53CHEK10.96742197
54MAP3K60.96307066
55MAPK130.95883592
56TTK0.95843176
57RET0.94476218
58OBSCN0.93869267
59TSSK60.91692122
60PDGFRA0.91482775
61MAPK120.90799909
62MAP2K40.89244894
63RPS6KB10.87994975
64MAP2K70.87940699
65STK380.87424401
66CSNK1G20.85839773
67CSNK1D0.85185537
68BRD40.84607273
69FRK0.84581827
70FGFR10.83788261
71RIPK10.83549017
72DYRK20.83306636
73FGFR20.81384664
74NTRK10.80914268
75MAP3K100.80784777
76UHMK10.80168712
77CDK140.79691881
78NEK90.78947695
79CDK150.78207169
80CDK180.76971825
81ATM0.76741950
82DAPK20.75675106
83EPHA20.74841613
84PLK10.74816049
85CDK30.74615633
86CDK20.74464773
87MTOR0.73785327
88PAK30.73699105
89CAMKK10.73473797
90MAPK70.71473029
91RPS6KB20.70765146
92CDK50.69729323
93CSNK1E0.69310125
94ATR0.67242488
95ACVR1B0.65764147
96CDK10.64946061
97CDK11A0.63629473
98NEK60.63562273
99STK110.62876172
100DYRK1A0.62093251
101FER0.60953813
102BCR0.60851414
103IRAK20.60713730
104CAMK1G0.60105740
105PAK20.60071583
106SGK10.59279222
107TRIB30.59235275
108CDK60.59184660
109MAPK100.59149363
110MARK20.58871401
111TLK10.57891437
112PRKDC0.56678590
113MET0.56567294
114NLK0.55618659
115MELK0.54737339
116BRSK20.54052655
117CAMK40.53855936
118CSNK1A1L0.52315715
119GSK3B0.51981175
120WNK10.51698713
121DDR20.51076890
122CSNK1G30.50108837
123CAMK2B0.49885373
124AURKA0.48197095
125MKNK10.47250152
126BRSK10.47164392
127STK30.47155383
128DAPK10.45979633
129MAP3K10.45116994
130MAP3K80.45032757
131MOS0.44723416
132PDGFRB0.44630528
133RPS6KA30.44027242
134MAPK140.43927062
135PRKCG0.43721534
136BMX0.43372125
137ERBB40.43312192
138CAMK1D0.42771267
139PRKAA10.38675443
140ROCK20.38294177
141DYRK1B0.37663514
142PTK20.35416086
143RPS6KA20.35081718
144BRAF0.34782352
145DYRK30.31800367

Predicted pathways (KEGG)

RankGene SetZ-score
1Long-term potentiation_Homo sapiens_hsa047201.99559753
2Synaptic vesicle cycle_Homo sapiens_hsa047211.99289399
3Alcoholism_Homo sapiens_hsa050341.97482545
4Nicotine addiction_Homo sapiens_hsa050331.95149626
5Oocyte meiosis_Homo sapiens_hsa041141.94209103
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.78507037
7Systemic lupus erythematosus_Homo sapiens_hsa053221.74513902
8mRNA surveillance pathway_Homo sapiens_hsa030151.67973320
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.66699588
10Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.64057182
11Dopaminergic synapse_Homo sapiens_hsa047281.56603538
12mTOR signaling pathway_Homo sapiens_hsa041501.54848588
13Hippo signaling pathway_Homo sapiens_hsa043901.54409908
14RNA transport_Homo sapiens_hsa030131.53562016
15Amphetamine addiction_Homo sapiens_hsa050311.51848781
16Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.50542741
17Colorectal cancer_Homo sapiens_hsa052101.48008643
18Dilated cardiomyopathy_Homo sapiens_hsa054141.44733300
19Endometrial cancer_Homo sapiens_hsa052131.42975481
20Glioma_Homo sapiens_hsa052141.41696549
21GABAergic synapse_Homo sapiens_hsa047271.41672533
22Circadian entrainment_Homo sapiens_hsa047131.41558423
23Estrogen signaling pathway_Homo sapiens_hsa049151.36649774
24Cell cycle_Homo sapiens_hsa041101.33883750
25Axon guidance_Homo sapiens_hsa043601.31438577
26Glutamatergic synapse_Homo sapiens_hsa047241.30556506
27Olfactory transduction_Homo sapiens_hsa047401.30237293
28Type II diabetes mellitus_Homo sapiens_hsa049301.29241654
29Gap junction_Homo sapiens_hsa045401.26843782
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.26380994
31Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.26313604
32Hedgehog signaling pathway_Homo sapiens_hsa043401.26247174
33Basal cell carcinoma_Homo sapiens_hsa052171.23183185
34ErbB signaling pathway_Homo sapiens_hsa040121.22771179
35Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.22381386
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.21657144
37Insulin secretion_Homo sapiens_hsa049111.21112269
38Melanogenesis_Homo sapiens_hsa049161.20506993
39Cholinergic synapse_Homo sapiens_hsa047251.19376119
40Dorso-ventral axis formation_Homo sapiens_hsa043201.18455653
41Central carbon metabolism in cancer_Homo sapiens_hsa052301.17395030
42Long-term depression_Homo sapiens_hsa047301.16493075
43Renal cell carcinoma_Homo sapiens_hsa052111.15940358
44Morphine addiction_Homo sapiens_hsa050321.15711446
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.15649353
46MicroRNAs in cancer_Homo sapiens_hsa052061.15530858
47Thyroid hormone signaling pathway_Homo sapiens_hsa049191.15226595
48ECM-receptor interaction_Homo sapiens_hsa045121.14839694
49Wnt signaling pathway_Homo sapiens_hsa043101.14698888
50Prolactin signaling pathway_Homo sapiens_hsa049171.14685399
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11118918
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09591518
53Circadian rhythm_Homo sapiens_hsa047101.06428018
54Adherens junction_Homo sapiens_hsa045201.06331573
55Tight junction_Homo sapiens_hsa045301.04088025
56Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.03722319
57GnRH signaling pathway_Homo sapiens_hsa049121.03226414
58Oxytocin signaling pathway_Homo sapiens_hsa049211.02683166
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.01121802
60Viral carcinogenesis_Homo sapiens_hsa052031.00932006
61Cocaine addiction_Homo sapiens_hsa050300.99923739
62Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.97889767
63Amoebiasis_Homo sapiens_hsa051460.97052865
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.96600585
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93642392
66Gastric acid secretion_Homo sapiens_hsa049710.93625988
67Renin secretion_Homo sapiens_hsa049240.93241637
68Salivary secretion_Homo sapiens_hsa049700.92073026
69Non-small cell lung cancer_Homo sapiens_hsa052230.90987716
70Aldosterone synthesis and secretion_Homo sapiens_hsa049250.89205996
71Mismatch repair_Homo sapiens_hsa034300.87326668
72TGF-beta signaling pathway_Homo sapiens_hsa043500.87301896
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.86952695
74AMPK signaling pathway_Homo sapiens_hsa041520.86148830
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86018454
76Small cell lung cancer_Homo sapiens_hsa052220.85678492
77Chronic myeloid leukemia_Homo sapiens_hsa052200.83922079
78Thyroid cancer_Homo sapiens_hsa052160.83350841
79Proteoglycans in cancer_Homo sapiens_hsa052050.82527627
80Spliceosome_Homo sapiens_hsa030400.82409258
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81513782
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80649667
83Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.79854043
84Glucagon signaling pathway_Homo sapiens_hsa049220.78389306
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78092379
86Prion diseases_Homo sapiens_hsa050200.76966119
87MAPK signaling pathway_Homo sapiens_hsa040100.76555234
88Serotonergic synapse_Homo sapiens_hsa047260.75340706
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75307750
90Melanoma_Homo sapiens_hsa052180.73238638
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72206838
92VEGF signaling pathway_Homo sapiens_hsa043700.70587740
93Taste transduction_Homo sapiens_hsa047420.70460943
94cAMP signaling pathway_Homo sapiens_hsa040240.69962871
95Bladder cancer_Homo sapiens_hsa052190.69493640
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66833903
97Acute myeloid leukemia_Homo sapiens_hsa052210.65879814
98Insulin signaling pathway_Homo sapiens_hsa049100.65786912
99Prostate cancer_Homo sapiens_hsa052150.65608726
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65146368
101Rap1 signaling pathway_Homo sapiens_hsa040150.64936526
102Sphingolipid metabolism_Homo sapiens_hsa006000.64477158
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.63933614
104Thyroid hormone synthesis_Homo sapiens_hsa049180.63857223
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63633793
106Choline metabolism in cancer_Homo sapiens_hsa052310.63508539
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.62514380
108Lysine degradation_Homo sapiens_hsa003100.61538872
109HIF-1 signaling pathway_Homo sapiens_hsa040660.59300574
110Focal adhesion_Homo sapiens_hsa045100.59108514
111Inositol phosphate metabolism_Homo sapiens_hsa005620.58625095
112Pancreatic cancer_Homo sapiens_hsa052120.58622337
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56906565
114HTLV-I infection_Homo sapiens_hsa051660.55962207
115Vibrio cholerae infection_Homo sapiens_hsa051100.55410805
116Endocytosis_Homo sapiens_hsa041440.54133047
117Ras signaling pathway_Homo sapiens_hsa040140.54025190
118Pathways in cancer_Homo sapiens_hsa052000.53830983
119Phototransduction_Homo sapiens_hsa047440.52921275
120One carbon pool by folate_Homo sapiens_hsa006700.52385158
121FoxO signaling pathway_Homo sapiens_hsa040680.51635977

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