FEM1C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)5.52715300
2mitotic sister chromatid cohesion (GO:0007064)5.16482344
3cell wall macromolecule metabolic process (GO:0044036)4.81482388
4cell wall macromolecule catabolic process (GO:0016998)4.81482388
5cilium or flagellum-dependent cell motility (GO:0001539)4.75403452
6piRNA metabolic process (GO:0034587)4.56614375
7monoubiquitinated protein deubiquitination (GO:0035520)4.45295287
8nuclear pore complex assembly (GO:0051292)4.45155619
9multicellular organism reproduction (GO:0032504)4.44504460
10sperm motility (GO:0030317)4.44382635
11sperm-egg recognition (GO:0035036)4.35249344
12acrosome assembly (GO:0001675)4.18866380
13nuclear pore organization (GO:0006999)4.01030350
14cell-cell recognition (GO:0009988)3.97809898
15plasma membrane fusion (GO:0045026)3.97604423
16male meiosis (GO:0007140)3.96324186
17binding of sperm to zona pellucida (GO:0007339)3.89005500
18synaptonemal complex assembly (GO:0007130)3.85694193
19protein localization to chromosome, centromeric region (GO:0071459)3.74032217
20synaptonemal complex organization (GO:0070193)3.73623694
21spermatid development (GO:0007286)3.70264862
22acrosome reaction (GO:0007340)3.68265413
23reproduction (GO:0000003)3.65795501
24limb bud formation (GO:0060174)3.62749276
25axonemal dynein complex assembly (GO:0070286)3.59270104
26motile cilium assembly (GO:0044458)3.58431301
27pore complex assembly (GO:0046931)3.53426206
28sister chromatid cohesion (GO:0007062)3.37731450
29microtubule depolymerization (GO:0007019)3.35178516
30NLS-bearing protein import into nucleus (GO:0006607)3.30352861
31regulation of RNA export from nucleus (GO:0046831)3.25119637
32regulation of heat generation (GO:0031650)3.24029454
33positive regulation of p38MAPK cascade (GO:1900745)3.23710347
34sarcoplasmic reticulum calcium ion transport (GO:0070296)3.22645655
35meiotic nuclear division (GO:0007126)3.17827033
36regulation of NFAT protein import into nucleus (GO:0051532)3.17697517
37chromosome condensation (GO:0030261)3.16754173
38regulation of fever generation (GO:0031620)3.13242401
39gene silencing by RNA (GO:0031047)3.13161124
40RNA stabilization (GO:0043489)3.13142108
41mRNA stabilization (GO:0048255)3.13142108
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.12390217
43DNA topological change (GO:0006265)3.10612349
44protein localization to kinetochore (GO:0034501)3.09103958
45epithelial cilium movement (GO:0003351)3.08924501
46DNA packaging (GO:0006323)3.08529061
47mitotic chromosome condensation (GO:0007076)3.04586187
48negative regulation of histone methylation (GO:0031061)2.99856319
49positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.97284441
50positive regulation of heat generation (GO:0031652)2.95155297
51regulation of DNA endoreduplication (GO:0032875)2.95076748
52meiotic chromosome segregation (GO:0045132)2.92356030
53regulation of histone H3-K27 methylation (GO:0061085)2.91224844
543-UTR-mediated mRNA stabilization (GO:0070935)2.90585385
55chromosome organization involved in meiosis (GO:0070192)2.90512165
56regulation of relaxation of muscle (GO:1901077)2.89608606
57regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.88355761
58epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.88007712
59regulation of spindle checkpoint (GO:0090231)2.87713287
60regulation of sarcomere organization (GO:0060297)2.87155200
61interleukin-6-mediated signaling pathway (GO:0070102)2.85399671
62regulation of cell communication by electrical coupling (GO:0010649)2.84880801
63protein localization to chromosome (GO:0034502)2.84346737
64mitotic nuclear envelope disassembly (GO:0007077)2.84304548
65response to peptidoglycan (GO:0032494)2.84168220
66regulation of centriole replication (GO:0046599)2.83703647
67meiotic cell cycle (GO:0051321)2.82155949
68regulation of cilium movement (GO:0003352)2.79960652
69pre-miRNA processing (GO:0031054)2.79283156
70regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.78713663
71regulation of mRNA stability (GO:0043488)2.75963165
72membrane disassembly (GO:0030397)2.71131223
73nuclear envelope disassembly (GO:0051081)2.71131223
74response to inactivity (GO:0014854)2.69516655
75single fertilization (GO:0007338)2.69400342
76dosage compensation (GO:0007549)2.68510106
77positive regulation of mitotic sister chromatid separation (GO:1901970)2.68023933
78positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.68023933
79positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.68023933
80regulation of histone H3-K9 methylation (GO:0051570)2.66999406
81regulation of p38MAPK cascade (GO:1900744)2.64490778
82spermatogenesis (GO:0007283)2.64487517
83regulation of RNA stability (GO:0043487)2.64050162
84male gamete generation (GO:0048232)2.63809949
85DNA methylation involved in gamete generation (GO:0043046)2.63271684
86translesion synthesis (GO:0019985)2.62266084
87regulation of spindle organization (GO:0090224)2.59636375
88negative regulation of NF-kappaB import into nucleus (GO:0042347)2.59366536
89regulation of actin filament-based movement (GO:1903115)2.58727956
90regulation of nucleobase-containing compound transport (GO:0032239)2.58370612
91negative regulation of systemic arterial blood pressure (GO:0003085)2.57706111
92histone H2A acetylation (GO:0043968)2.57473816
93mitotic metaphase plate congression (GO:0007080)2.57248928
94male meiosis I (GO:0007141)2.56705753
95negative regulation of neurotransmitter secretion (GO:0046929)2.55935327
96cytoplasmic mRNA processing body assembly (GO:0033962)2.55125573
97germinal center formation (GO:0002467)2.54188523
98definitive hemopoiesis (GO:0060216)2.51371691
99spindle assembly involved in mitosis (GO:0090307)2.51330001
100regulation of cardiac muscle cell contraction (GO:0086004)2.50486566
101hepatocyte apoptotic process (GO:0097284)2.50231000
102DNA conformation change (GO:0071103)2.49644431
103gamete generation (GO:0007276)2.48877524
104regulation of chromatin binding (GO:0035561)2.48750024
105sister chromatid segregation (GO:0000819)2.48427348
106regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.48241710
107negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.46777892
108regulation of pigment cell differentiation (GO:0050932)2.46595580
109fertilization (GO:0009566)2.46484468
110DNA damage response, signal transduction resulting in transcription (GO:0042772)2.46365271
111histone exchange (GO:0043486)2.46291974
112metaphase plate congression (GO:0051310)2.45936367
113regulation of meiosis I (GO:0060631)2.45644341
114nucleosome disassembly (GO:0006337)2.45033008
115protein-DNA complex disassembly (GO:0032986)2.45033008
116immunoglobulin mediated immune response (GO:0016064)2.44557267
117kinetochore organization (GO:0051383)2.44271836
118positive regulation of gamma-delta T cell activation (GO:0046645)2.43881545
119germ cell development (GO:0007281)2.43686044
120seminiferous tubule development (GO:0072520)2.41055717
121positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.40906481
122positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.40898748
123regulation of germinal center formation (GO:0002634)2.40896460
124ATP-dependent chromatin remodeling (GO:0043044)2.40741393
125regulation of chromosome segregation (GO:0051983)2.39932470
126negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.39710957
127regulation of interleukin-8 biosynthetic process (GO:0045414)2.38514968
128meiotic cell cycle process (GO:1903046)2.38418874
129negative regulation of vascular permeability (GO:0043116)2.35549312
130negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.35507691
131cellular response to ethanol (GO:0071361)2.35494160
132histone H3-K4 trimethylation (GO:0080182)2.32811737
133response to muramyl dipeptide (GO:0032495)2.28890115
134positive regulation of nitric oxide biosynthetic process (GO:0045429)2.28761247
135regulation of transforming growth factor beta2 production (GO:0032909)2.28351422
136detection of molecule of bacterial origin (GO:0032490)2.27245007
137neutrophil mediated immunity (GO:0002446)2.26984561
138platelet-derived growth factor receptor signaling pathway (GO:0048008)2.26723578
139interkinetic nuclear migration (GO:0022027)2.25466111
140regulation of vitamin D biosynthetic process (GO:0060556)2.25053441
141Notch signaling involved in heart development (GO:0061314)2.24852644
142pericardium development (GO:0060039)2.23759194
143nerve growth factor signaling pathway (GO:0038180)2.23718174
144T-helper 1 type immune response (GO:0042088)2.23284916
145positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.23281908
146regulation of chemokine-mediated signaling pathway (GO:0070099)2.23140838
147embryonic process involved in female pregnancy (GO:0060136)2.18750430
148relaxation of cardiac muscle (GO:0055119)2.18484397
149regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.17699621
150regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.17415386
151fibroblast migration (GO:0010761)2.15313205
152regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.15291394
153regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.14878959
154artery development (GO:0060840)2.14015371
155ventricular septum morphogenesis (GO:0060412)2.11664576
156myofibril assembly (GO:0030239)2.08634373
157regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.08583490
158neural tube formation (GO:0001841)2.07599549
159coronary vasculature morphogenesis (GO:0060977)2.06919674
160negative regulation of Rho protein signal transduction (GO:0035024)2.05734754
161negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.05428118
162negative regulation of translation, ncRNA-mediated (GO:0040033)2.05428118
163regulation of translation, ncRNA-mediated (GO:0045974)2.05428118
164response to laminar fluid shear stress (GO:0034616)2.05271292
165vesicle transport along microtubule (GO:0047496)2.03656903
166central nervous system projection neuron axonogenesis (GO:0021952)2.02596511
167protein targeting to lysosome (GO:0006622)2.00623106
168establishment of protein localization to vacuole (GO:0072666)2.00623106
169protein targeting to vacuole (GO:0006623)2.00623106
170regulation of necroptotic process (GO:0060544)2.00296434
171phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)1.99375469
172regulation of nitric oxide biosynthetic process (GO:0045428)1.98821443
173negative regulation of mast cell activation (GO:0033004)1.98805094
174regulation of interferon-alpha production (GO:0032647)1.97829795
175regulation of nitric-oxide synthase biosynthetic process (GO:0051769)1.97610384
176somite development (GO:0061053)1.96793978
177SMAD protein complex assembly (GO:0007183)1.96443611
178snRNA transcription (GO:0009301)1.95941549
179positive regulation of toll-like receptor signaling pathway (GO:0034123)1.95301267
180regulation of macrophage cytokine production (GO:0010935)1.94714802
181skeletal muscle adaptation (GO:0043501)1.94246146
182positive regulation of macrophage cytokine production (GO:0060907)1.93744411
183regulation of ER to Golgi vesicle-mediated transport (GO:0060628)1.93097355
184macrophage activation involved in immune response (GO:0002281)1.91647062
185negative regulation of neurotransmitter transport (GO:0051589)1.91251811
186retina vasculature morphogenesis in camera-type eye (GO:0061299)1.90580645
187regulation of T-helper 1 cell differentiation (GO:0045625)1.90275136
188negative regulation of lipid storage (GO:0010888)1.88875085
189regulation of interferon-beta biosynthetic process (GO:0045357)1.88785873
190oligosaccharide catabolic process (GO:0009313)1.88720239
191phospholipid translocation (GO:0045332)1.87265506
192lipid translocation (GO:0034204)1.87265506
193myelin assembly (GO:0032288)1.86878554
194regulation of interleukin-12 biosynthetic process (GO:0045075)1.85756780
195cardiac myofibril assembly (GO:0055003)1.85738989
196olfactory bulb development (GO:0021772)1.85677778
197glial cell proliferation (GO:0014009)1.85496268
198cellular response to arsenic-containing substance (GO:0071243)1.85274705

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.63866702
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.77261742
3FOXM1_23109430_ChIP-Seq_U2OS_Human5.00857707
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.10900894
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.99446350
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.88512710
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.64573200
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.60145550
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.48234724
10EZH2_22144423_ChIP-Seq_EOC_Human2.42891689
11ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.42169536
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.40997673
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.37899443
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.31309352
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.29261095
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.29243675
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.27213445
18GBX2_23144817_ChIP-Seq_PC3_Human2.25042480
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.11523341
20IRF8_27001747_Chip-Seq_BMDM_Mouse2.11315282
21* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.10285400
22TP63_19390658_ChIP-ChIP_HaCaT_Human2.06555159
23* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.05353980
24SALL1_21062744_ChIP-ChIP_HESCs_Human1.99852896
25ZNF217_24962896_ChIP-Seq_MCF-7_Human1.99055575
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.98912289
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.98439462
28MYC_22102868_ChIP-Seq_BL_Human1.97455615
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.97306135
30SCL_19346495_ChIP-Seq_HPC-7_Human1.97210683
31CDX2_19796622_ChIP-Seq_MESCs_Mouse1.93401001
32MYB_26560356_Chip-Seq_TH2_Human1.93191344
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.93098969
34TCF7_22412390_ChIP-Seq_EML_Mouse1.92643439
35SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.92277654
36* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.89128817
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89003047
38* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.87973834
39MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.81822704
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.81755895
41MYB_26560356_Chip-Seq_TH1_Human1.81254104
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.80667546
43Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.79144336
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.76682228
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.76242597
46VDR_24787735_ChIP-Seq_THP-1_Human1.71362522
47OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.70746172
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.70534417
49CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.70020297
50TAF15_26573619_Chip-Seq_HEK293_Human1.69575062
51NRF2_20460467_ChIP-Seq_MEFs_Mouse1.65426541
52NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.65426541
53EP300_21415370_ChIP-Seq_HL-1_Mouse1.65375490
54BRD4_27068464_Chip-Seq_AML-cells_Mouse1.62831160
55IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.58148396
56* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.56591510
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.53173673
58TP53_16413492_ChIP-PET_HCT116_Human1.53059018
59* SMAD4_21799915_ChIP-Seq_A2780_Human1.52059309
60WT1_19549856_ChIP-ChIP_CCG9911_Human1.50002112
61NR3C1_21868756_ChIP-Seq_MCF10A_Human1.47653110
62TP53_18474530_ChIP-ChIP_U2OS_Human1.47561888
63P300_19829295_ChIP-Seq_ESCs_Human1.46114584
64SPI1_23547873_ChIP-Seq_NB4_Human1.45367702
65CJUN_26792858_Chip-Seq_BT549_Human1.45100929
66SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44992780
67RUNX1_22412390_ChIP-Seq_EML_Mouse1.42299346
68AHR_22903824_ChIP-Seq_MCF-7_Human1.40348546
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38306757
70RUNX_20019798_ChIP-Seq_JUKART_Human1.37200266
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.35447569
72ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.34812023
73AR_21909140_ChIP-Seq_LNCAP_Human1.34758248
74MAF_26560356_Chip-Seq_TH1_Human1.34323702
75VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.34047897
76TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33510931
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33326405
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.33146724
79ESR1_20079471_ChIP-ChIP_T-47D_Human1.32363378
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32145817
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30076969
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30076969
83FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.29240024
84STAT3_23295773_ChIP-Seq_U87_Human1.28951198
85* RXR_22108803_ChIP-Seq_LS180_Human1.26864262
86TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24444719
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22816389
88KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22277866
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.22101376
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.22093549
91UTX_26944678_Chip-Seq_JUKART_Human1.20617964
92PU_27001747_Chip-Seq_BMDM_Mouse1.20460110
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20330105
94STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18476098
95AR_21572438_ChIP-Seq_LNCaP_Human1.18468879
96FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18409389
97SALL4_18804426_ChIP-ChIP_XEN_Mouse1.17083981
98CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16844904
99FUS_26573619_Chip-Seq_HEK293_Human1.16113096
100* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15456579
101UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14164819
102* NOTCH1_21737748_ChIP-Seq_TLL_Human1.11944659
103GATA2_21666600_ChIP-Seq_HMVEC_Human1.11298054
104BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11142648
105ER_23166858_ChIP-Seq_MCF-7_Human1.10920398
106CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10886643
107LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10853502
108VDR_22108803_ChIP-Seq_LS180_Human1.10388865
109BCAT_22108803_ChIP-Seq_LS180_Human1.10217321
110PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09406372
111SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08439952
112* TCF4_23295773_ChIP-Seq_U87_Human1.08389277
113STAT4_19710469_ChIP-ChIP_TH1__Mouse1.07992562
114RBPJ_22232070_ChIP-Seq_NCS_Mouse1.07946399
115TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.07645240
116EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06945508
117FLI1_21867929_ChIP-Seq_TH2_Mouse1.06807148
118VDR_21846776_ChIP-Seq_THP-1_Human1.06638010
119* BRD4_25478319_ChIP-Seq_HGPS_Human1.06622785
120RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05863343
121AR_25329375_ChIP-Seq_VCAP_Human1.05851535
122KDM2B_26808549_Chip-Seq_REH_Human1.05253262
123NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04772954
124EZH2_27294783_Chip-Seq_NPCs_Mouse1.04734711
125CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04548162
126CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.04450522
127STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.03150919
128TP63_23658742_ChIP-Seq_EP156T_Human1.03070587
129EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03058009
130P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03002677
131KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02862042
132DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02459732
133GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01906756
134CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01426325
135RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01228053
136CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00752042
137MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00670343
138PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00565201
139PKCTHETA_26484144_Chip-Seq_BREAST_Human1.00550860
140YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00546859
141TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00311423
142E2F1_18555785_Chip-Seq_ESCs_Mouse0.99839020
143GATA3_27048872_Chip-Seq_THYMUS_Human0.99480876
144NCOR1_26117541_ChIP-Seq_K562_Human0.99422042
145SOX2_21211035_ChIP-Seq_LN229_Gbm0.99339911
146ETS1_22383799_ChIP-Seq_G1ME_Mouse0.99298226
147PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.99215641
148TCF4_18268006_ChIP-ChIP_LS174T_Human0.99205076
149NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99097090
150MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97312582
151SPI1_23127762_ChIP-Seq_K562_Human0.94345371
152RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93311456
153VDR_24763502_ChIP-Seq_THP-1_Human0.92104158
154SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92061305
155FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.89816594
156GATA1_26923725_Chip-Seq_HPCs_Mouse0.89192053
157HOXB4_20404135_ChIP-ChIP_EML_Mouse0.88977082
158* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.87270284
159HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.87201029
160NFIB_24661679_ChIP-Seq_LUNG_Mouse0.86746022
161CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.85462074
162FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83782074
163PADI4_21655091_ChIP-ChIP_MCF-7_Human0.78957511
164FLI1_27457419_Chip-Seq_LIVER_Mouse0.77791073
165SMAD_19615063_ChIP-ChIP_OVARY_Human0.75651670
166TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.75479736
167CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75043947
168POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.74791003
169E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.74686412
170KLF4_18555785_ChIP-Seq_MESCs_Mouse0.74013155
171FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.73984473
172* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.73490033
173KDM2B_26808549_Chip-Seq_DND41_Human0.72783277
174GATA3_26560356_Chip-Seq_TH1_Human0.71685321
175KAP1_22055183_ChIP-Seq_ESCs_Mouse0.71475128
176WDR5_24793694_ChIP-Seq_LNCAP_Human0.70468480
177SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.69376313
178* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.69323499
179KDM5A_27292631_Chip-Seq_BREAST_Human0.68320609
180CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.68021267
181ELK4_26923725_Chip-Seq_MESODERM_Mouse0.67955472
182RUNX1_26923725_Chip-Seq_HPCs_Mouse0.67728573
183CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.67494113

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization4.55093367
2MP0002332_abnormal_exercise_endurance3.46077886
3MP0004510_myositis3.23546249
4MP0008057_abnormal_DNA_replication2.98262710
5MP0008877_abnormal_DNA_methylation2.89316581
6MP0009278_abnormal_bone_marrow2.87480278
7MP0003950_abnormal_plasma_membrane2.85244290
8MP0004084_abnormal_cardiac_muscle2.67043767
9MP0003221_abnormal_cardiomyocyte_apopto2.59796545
10MP0003724_increased_susceptibility_to2.56184095
11MP0010094_abnormal_chromosome_stability2.50753730
12MP0000569_abnormal_digit_pigmentation2.42200086
13MP0004808_abnormal_hematopoietic_stem2.37577792
14MP0003091_abnormal_cell_migration2.35950363
15MP0005076_abnormal_cell_differentiation2.24900752
16MP0004484_altered_response_of2.24769473
17MP0002396_abnormal_hematopoietic_system2.24034800
18MP0008007_abnormal_cellular_replicative2.23128992
19MP0001929_abnormal_gametogenesis2.22658633
20MP0010352_gastrointestinal_tract_polyps2.19291605
21MP0005397_hematopoietic_system_phenotyp2.17672908
22MP0001545_abnormal_hematopoietic_system2.17672908
23MP0003077_abnormal_cell_cycle2.17303173
24MP0008058_abnormal_DNA_repair2.17217796
25MP0001835_abnormal_antigen_presentation2.13683882
26MP0003698_abnormal_male_reproductive1.99982037
27MP0003111_abnormal_nucleus_morphology1.97583468
28MP0003646_muscle_fatigue1.96553414
29MP0010307_abnormal_tumor_latency1.89301640
30MP0003436_decreased_susceptibility_to1.86003233
31MP0002210_abnormal_sex_determination1.82040371
32MP0003693_abnormal_embryo_hatching1.80869110
33MP0001501_abnormal_sleep_pattern1.74222204
34MP0004036_abnormal_muscle_relaxation1.72881158
35MP0004215_abnormal_myocardial_fiber1.72526920
36MP0003656_abnormal_erythrocyte_physiolo1.69838339
37MP0003303_peritoneal_inflammation1.66819467
38MP0005167_abnormal_blood-brain_barrier1.64760774
39MP0005671_abnormal_response_to1.63623919
40MP0004957_abnormal_blastocyst_morpholog1.60350805
41MP0002972_abnormal_cardiac_muscle1.59806947
42MP0005248_abnormal_Harderian_gland1.59597688
43MP0002398_abnormal_bone_marrow1.59038951
44MP0003045_fibrosis1.56655534
45MP0000751_myopathy1.54441539
46MP0002452_abnormal_antigen_presenting1.52901737
47MP0005666_abnormal_adipose_tissue1.52335619
48MP0005620_abnormal_muscle_contractility1.50047532
49MP0001800_abnormal_humoral_immune1.49691847
50MP0001145_abnormal_male_reproductive1.49015740
51MP0002009_preneoplasia1.47868818
52MP0003191_abnormal_cellular_cholesterol1.47851849
53MP0005000_abnormal_immune_tolerance1.46121719
54MP0005174_abnormal_tail_pigmentation1.45465430
55MP0002405_respiratory_system_inflammati1.44236879
56MP0009764_decreased_sensitivity_to1.39276860
57MP0001819_abnormal_immune_cell1.39068981
58MP0002420_abnormal_adaptive_immunity1.38746921
59MP0005164_abnormal_response_to1.38692895
60MP0009115_abnormal_fat_cell1.36950714
61MP0002723_abnormal_immune_serum1.36469972
62MP0003763_abnormal_thymus_physiology1.36403891
63MP0000350_abnormal_cell_proliferation1.36160273
64MP0002419_abnormal_innate_immunity1.35820912
65MP0000749_muscle_degeneration1.34873194
66MP0001730_embryonic_growth_arrest1.33578776
67MP0000653_abnormal_sex_gland1.31279295
68MP0000685_abnormal_immune_system1.31043058
69MP0002086_abnormal_extraembryonic_tissu1.30982534
70MP0000703_abnormal_thymus_morphology1.30426278
71MP0004130_abnormal_muscle_cell1.30099999
72MP0002166_altered_tumor_susceptibility1.29824957
73MP0000716_abnormal_immune_system1.28995479
74MP0005025_abnormal_response_to1.26807059
75MP0003984_embryonic_growth_retardation1.26674203
76MP0003828_pulmonary_edema1.26589624
77MP0000490_abnormal_crypts_of1.26085466
78MP0002088_abnormal_embryonic_growth/wei1.25767657
79MP0003448_altered_tumor_morphology1.24821248
80MP0005380_embryogenesis_phenotype1.24663853
81MP0001672_abnormal_embryogenesis/_devel1.24663853
82MP0003868_abnormal_feces_composition1.24255927
83MP0009785_altered_susceptibility_to1.23847206
84MP0003941_abnormal_skin_development1.23006628
85MP0010678_abnormal_skin_adnexa1.22537480
86MP0006054_spinal_hemorrhage1.22004464
87MP0000689_abnormal_spleen_morphology1.21620570
88MP0002722_abnormal_immune_system1.21210012
89MP0003943_abnormal_hepatobiliary_system1.20192481
90MP0008004_abnormal_stomach_pH1.20123579
91MP0010368_abnormal_lymphatic_system1.18604532
92MP0004883_abnormal_blood_vessel1.18490808
93MP0002006_tumorigenesis1.18285670
94MP0000516_abnormal_urinary_system1.17544326
95MP0005367_renal/urinary_system_phenotyp1.17544326
96MP0003300_gastrointestinal_ulcer1.17502828
97MP0002161_abnormal_fertility/fecundity1.17078406
98MP0005266_abnormal_metabolism1.17000315
99MP0006138_congestive_heart_failure1.16402776
100MP0001697_abnormal_embryo_size1.14287966
101MP0002429_abnormal_blood_cell1.13654841
102MP0002106_abnormal_muscle_physiology1.11689933
103MP0002084_abnormal_developmental_patter1.11327323
104MP0003567_abnormal_fetal_cardiomyocyte1.09950868
105MP0001879_abnormal_lymphatic_vessel1.09825249
106MP0004270_analgesia1.09689664
107MP0004087_abnormal_muscle_fiber1.08955126
108MP0002148_abnormal_hypersensitivity_rea1.08812943
109MP0006082_CNS_inflammation1.08495573
110MP0001177_atelectasis1.07229333
111MP0008961_abnormal_basal_metabolism1.07104466
112MP0003890_abnormal_embryonic-extraembry1.05653682
113MP0005670_abnormal_white_adipose1.04905416
114MP0010234_abnormal_vibrissa_follicle1.04820240
115MP0002877_abnormal_melanocyte_morpholog1.03785942
116MP0002019_abnormal_tumor_incidence1.03485317
117MP0002133_abnormal_respiratory_system1.03378496
118MP0005388_respiratory_system_phenotype1.03378496
119MP0000249_abnormal_blood_vessel1.03244608
120MP0009333_abnormal_splenocyte_physiolog1.02980815
121MP0001790_abnormal_immune_system1.02551431
122MP0005387_immune_system_phenotype1.02551431
123MP0003453_abnormal_keratinocyte_physiol1.00616403
124MP0002971_abnormal_brown_adipose0.99539727
125MP0003690_abnormal_glial_cell0.97291916
126MP0002998_abnormal_bone_remodeling0.96206844
127MP0000858_altered_metastatic_potential0.96164962
128MP0001851_eye_inflammation0.95842235
129MP0000313_abnormal_cell_death0.95813872
130MP0002085_abnormal_embryonic_tissue0.95498217
131MP0005464_abnormal_platelet_physiology0.95461847
132MP0004197_abnormal_fetal_growth/weight/0.94500258
133MP0010155_abnormal_intestine_physiology0.94308732
134MP0001440_abnormal_grooming_behavior0.93696352
135MP0000604_amyloidosis0.93535591
136MP0002925_abnormal_cardiovascular_devel0.91445897
137MP0000733_abnormal_muscle_development0.90842995
138MP0000778_abnormal_nervous_system0.90034236
139MP0002138_abnormal_hepatobiliary_system0.89824233
140MP0010630_abnormal_cardiac_muscle0.89633666
141MP0000465_gastrointestinal_hemorrhage0.89551799
142MP0002080_prenatal_lethality0.89462472
143MP0001853_heart_inflammation0.88988809
144MP0000343_altered_response_to0.88318460
145MP0001544_abnormal_cardiovascular_syste0.88213513
146MP0005385_cardiovascular_system_phenoty0.88213513
147MP0000767_abnormal_smooth_muscle0.88001647
148MP0001293_anophthalmia0.86337995
149MP0002168_other_aberrant_phenotype0.86295723
150MP0003705_abnormal_hypodermis_morpholog0.85764623
151MP0002735_abnormal_chemical_nociception0.85752720
152MP0001119_abnormal_female_reproductive0.85440796
153MP0000537_abnormal_urethra_morphology0.84652019
154MP0004947_skin_inflammation0.83175991
155MP0005375_adipose_tissue_phenotype0.82995411
156MP0004233_abnormal_muscle_weight0.82989521
157MP0003195_calcinosis0.82903563
158MP0000383_abnormal_hair_follicle0.81603608
159MP0005595_abnormal_vascular_smooth0.81139551
160MP0003075_altered_response_to0.80533570
161MP0005165_increased_susceptibility_to0.79193757
162MP0001845_abnormal_inflammatory_respons0.78293180
163MP0005334_abnormal_fat_pad0.77762007
164MP0005166_decreased_susceptibility_to0.77725051
165MP0000015_abnormal_ear_pigmentation0.76945841
166MP0000759_abnormal_skeletal_muscle0.76789371
167MP0005386_behavior/neurological_phenoty0.74435799
168MP0004924_abnormal_behavior0.74435799
169MP0000747_muscle_weakness0.74085902
170MP0005647_abnormal_sex_gland0.73474473
171MP0001915_intracranial_hemorrhage0.73013777
172MP0004264_abnormal_extraembryonic_tissu0.72702069
173MP0002092_abnormal_eye_morphology0.72474694
174MP0002282_abnormal_trachea_morphology0.71794918
175MP0001486_abnormal_startle_reflex0.70006510
176MP0002139_abnormal_hepatobiliary_system0.69255307
177MP0005369_muscle_phenotype0.68885943

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.13984092
2Absent/shortened dynein arms (HP:0200106)4.77110339
3Dynein arm defect of respiratory motile cilia (HP:0012255)4.77110339
4Nasal polyposis (HP:0100582)3.78665903
5Abnormality of the nasal mucosa (HP:0000433)3.23097167
6Exercise-induced muscle cramps (HP:0003710)3.20581768
7Abnormality of the fingertips (HP:0001211)3.20018245
8Subaortic stenosis (HP:0001682)3.18201309
9Abnormality of the left ventricular outflow tract (HP:0011103)3.18201309
10Adactyly (HP:0009776)3.18184876
11Fair hair (HP:0002286)2.96497530
12Hyporeflexia of lower limbs (HP:0002600)2.94900863
13Abnormal respiratory motile cilium physiology (HP:0012261)2.92766368
14Rhinitis (HP:0012384)2.92606806
15Abnormal respiratory motile cilium morphology (HP:0005938)2.86942780
16Abnormal respiratory epithelium morphology (HP:0012253)2.86942780
17Acute myeloid leukemia (HP:0004808)2.82313256
18Prostate neoplasm (HP:0100787)2.75103219
19Progressive cerebellar ataxia (HP:0002073)2.74260667
20Recurrent abscess formation (HP:0002722)2.73608483
21Muscle fiber splitting (HP:0003555)2.71466796
22Myositis (HP:0100614)2.69897109
23Hematochezia (HP:0002573)2.66840853
24Disinhibition (HP:0000734)2.66788599
25Volvulus (HP:0002580)2.66618405
26Febrile seizures (HP:0002373)2.65878467
27Chronic bronchitis (HP:0004469)2.65261662
28Infertility (HP:0000789)2.60292021
29Absent frontal sinuses (HP:0002688)2.52301949
30Abnormal hair whorl (HP:0010721)2.52014608
31Hyperventilation (HP:0002883)2.51789578
32Muscle fiber inclusion bodies (HP:0100299)2.51608546
33Asymmetric septal hypertrophy (HP:0001670)2.48665586
34Exercise-induced myalgia (HP:0003738)2.45763198
35Increased density of long bones (HP:0006392)2.43291170
36Recurrent bacterial skin infections (HP:0005406)2.41713999
37Facial hemangioma (HP:0000329)2.41642275
38Hepatoblastoma (HP:0002884)2.41633815
39Abnormal spermatogenesis (HP:0008669)2.41077196
40Action tremor (HP:0002345)2.40357565
41Bronchitis (HP:0012387)2.38451007
42Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.38328040
43Difficulty running (HP:0009046)2.38322860
44Heterotopia (HP:0002282)2.37274486
45Nemaline bodies (HP:0003798)2.37223087
46Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.36181374
47Short 4th metacarpal (HP:0010044)2.36181374
48Orchitis (HP:0100796)2.35345476
49Amyotrophic lateral sclerosis (HP:0007354)2.35195908
50Abnormality of the prostate (HP:0008775)2.35071649
51Widely spaced teeth (HP:0000687)2.35010132
52Papillary thyroid carcinoma (HP:0002895)2.34075154
53Exocrine pancreatic insufficiency (HP:0001738)2.31500396
54Abnormality of the calf musculature (HP:0001430)2.31398825
55Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.31241382
56Bundle branch block (HP:0011710)2.25750979
57Agnosia (HP:0010524)2.25557593
58Protruding tongue (HP:0010808)2.23760878
59Ectopic kidney (HP:0000086)2.22961659
60Sudden death (HP:0001699)2.22084014
61Distal arthrogryposis (HP:0005684)2.20876816
62Recurrent bronchitis (HP:0002837)2.20577238
63Drooling (HP:0002307)2.20560521
64Retrobulbar optic neuritis (HP:0100654)2.19974373
65Optic neuritis (HP:0100653)2.19974373
66Calf muscle hypertrophy (HP:0008981)2.17960405
67Male infertility (HP:0003251)2.17145483
68Upper motor neuron abnormality (HP:0002127)2.16415332
69EMG: myopathic abnormalities (HP:0003458)2.15356063
70Excessive salivation (HP:0003781)2.15054303
71Hypoplasia of the iris (HP:0007676)2.13900676
72Muscle hypertrophy of the lower extremities (HP:0008968)2.13808738
73Frequent falls (HP:0002359)2.13606865
74Syringomyelia (HP:0003396)2.12828785
75Spinal cord lesions (HP:0100561)2.12828785
76Truncal obesity (HP:0001956)2.12052552
77Bronchiectasis (HP:0002110)2.11997448
78Abnormality of the nasal septum (HP:0000419)2.11518904
79Large earlobe (HP:0009748)2.10740427
80Generalized hypopigmentation of hair (HP:0011358)2.10688255
81Axonal loss (HP:0003447)2.09125045
82Autoimmune thrombocytopenia (HP:0001973)2.09104970
83Long eyelashes (HP:0000527)2.07127315
84Depressed nasal tip (HP:0000437)2.05012239
85Impulsivity (HP:0100710)2.04791939
86Atrial fibrillation (HP:0005110)2.03633864
87Atonic seizures (HP:0010819)2.03106019
88Portal hypertension (HP:0001409)2.02080107
89Increased nuchal translucency (HP:0010880)2.01907990
90Recurrent viral infections (HP:0004429)2.00131949
91Myelodysplasia (HP:0002863)1.99876439
92Subacute progressive viral hepatitis (HP:0006572)1.99138324
93Abnormality of the pubic bones (HP:0003172)1.97754359
94Chromsome breakage (HP:0040012)1.97045670
95Cone-rod dystrophy (HP:0000548)1.93796062
96Curly hair (HP:0002212)1.93392907
97Neoplasm of the tracheobronchial system (HP:0100552)1.93381538
98Deviation of the thumb (HP:0009603)1.93284488
99Nephronophthisis (HP:0000090)1.93283717
100Onion bulb formation (HP:0003383)1.92950282
101Syncope (HP:0001279)1.92728480
102Long clavicles (HP:0000890)1.92590927
103Stomach cancer (HP:0012126)1.92556717
104Hyperkalemia (HP:0002153)1.91754301
105Proximal placement of thumb (HP:0009623)1.91583617
106Recurrent sinusitis (HP:0011108)1.90194959
107Chronic hepatic failure (HP:0100626)1.88915330
108Type 1 muscle fiber predominance (HP:0003803)1.88772179
109Mediastinal lymphadenopathy (HP:0100721)1.88272137
110Hypoplastic iliac wings (HP:0002866)1.87645198
111Hypoplastic nipples (HP:0002557)1.86651122
112Aplasia/Hypoplasia of the sternum (HP:0006714)1.86498585
113Neoplasm of the heart (HP:0100544)1.84083251
114Inappropriate behavior (HP:0000719)1.83808993
115Steppage gait (HP:0003376)1.82372508
116Eczematoid dermatitis (HP:0000976)1.81728255
117Narrow palate (HP:0000189)1.81612555
118Dislocated radial head (HP:0003083)1.81485335
119Prominent nose (HP:0000448)1.80326649
120Abnormal ciliary motility (HP:0012262)1.80033497
121Azoospermia (HP:0000027)1.79437147
122Abnormality of chromosome stability (HP:0003220)1.78960845
123Thyroid carcinoma (HP:0002890)1.78331746
124Short phalanx of the thumb (HP:0009660)1.78028142
125EMG: neuropathic changes (HP:0003445)1.77090290
126Choroideremia (HP:0001139)1.76207100
127Truncal ataxia (HP:0002078)1.75884669
128Lip pit (HP:0100267)1.75846090
129Abnormality of the musculature of the pelvis (HP:0001469)1.75794491
130Abnormality of the hip-girdle musculature (HP:0001445)1.75794491
131Cutis marmorata (HP:0000965)1.75205698
132Bicuspid aortic valve (HP:0001647)1.74607884
133Recurrent otitis media (HP:0000403)1.74592609
134Conjunctival telangiectasia (HP:0000524)1.74137551
135Capillary hemangiomas (HP:0005306)1.73908027
136Primary atrial arrhythmia (HP:0001692)1.73651126
137Absent speech (HP:0001344)1.72934654
138Global brain atrophy (HP:0002283)1.72760853
139Recurrent fungal infections (HP:0002841)1.72751795
140Breast carcinoma (HP:0003002)1.72211490
141Keratoconjunctivitis sicca (HP:0001097)1.71525630
142Genetic anticipation (HP:0003743)1.71369522
143Chromosomal breakage induced by crosslinking agents (HP:0003221)1.71064874
144Cystic hygroma (HP:0000476)1.70296015
145Abnormality of the radial head (HP:0003995)1.69736040
146Spondylolisthesis (HP:0003302)1.68418309
147Hypoplastic labia majora (HP:0000059)1.68357590
148Abnormality of the vasculature of the conjunctiva (HP:0008054)1.66800135
149Long nose (HP:0003189)1.65928532
150Metaphyseal dysplasia (HP:0100255)1.65436035
151Abnormal auditory evoked potentials (HP:0006958)1.64784368
152Constricted visual fields (HP:0001133)1.64691777
153Cubitus valgus (HP:0002967)1.64624918
154Myocardial infarction (HP:0001658)1.64461941
155Thyroiditis (HP:0100646)1.64090554
156Rectal prolapse (HP:0002035)1.63463699
157Exotropia (HP:0000577)1.63264031
158Arterial thrombosis (HP:0004420)1.63160712
159Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.61353168
160Abnormality of male internal genitalia (HP:0000022)1.61139691
161Dysmetric saccades (HP:0000641)1.61011284
1622-3 toe syndactyly (HP:0004691)1.60186391
163Abnormality of the renal medulla (HP:0100957)1.59815068
164Tubular atrophy (HP:0000092)1.58356701
165Colon cancer (HP:0003003)1.56532125
166Abnormality of the lower motor neuron (HP:0002366)1.56260699
167Broad palm (HP:0001169)1.56064177
168Tented upper lip vermilion (HP:0010804)1.55883402
169Broad ribs (HP:0000885)1.55806738
170Spontaneous hematomas (HP:0007420)1.55200403
171Aortic aneurysm (HP:0004942)1.54751787
172Amaurosis fugax (HP:0100576)1.54483689
173Vertebral arch anomaly (HP:0008438)1.54078165
174Birth length less than 3rd percentile (HP:0003561)1.54025642
175Tapered finger (HP:0001182)1.53916007
176Abnormality of the labia majora (HP:0012881)1.53590942
177Arterial tortuosity (HP:0005116)1.52248069
178Urethral obstruction (HP:0000796)1.49591576
179Low anterior hairline (HP:0000294)1.48996727
180Chronic obstructive pulmonary disease (HP:0006510)1.48880790
181Obstructive lung disease (HP:0006536)1.48880790
182Thrombocytosis (HP:0001894)1.48716874
183Neoplasm of the oral cavity (HP:0100649)1.47809496
184Basal cell carcinoma (HP:0002671)1.47788456
185Clubbing of toes (HP:0100760)1.47756219
186Abnormality of the hepatic vasculature (HP:0006707)1.47730398

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K103.24278916
2CDK122.91670306
3NEK22.89441255
4PDK32.74612900
5PDK42.74612900
6PDK22.65077735
7MAP4K12.40705516
8PRPF4B2.33582480
9WEE12.32323950
10NEK92.31008510
11BRSK22.24778989
12AKT32.24699062
13OBSCN2.17646956
14CDC72.11720207
15EPHA32.07297134
16PNCK2.06825447
17MAP3K92.06432443
18MARK11.98416843
19DYRK31.92776216
20CASK1.92712804
21STK31.86677197
22CDK61.82825569
23RPS6KA41.81435158
24TIE11.75725151
25ICK1.70882535
26EEF2K1.60005857
27PINK11.59640944
28KSR11.56084272
29MKNK21.55246024
30IRAK11.53205218
31SGK21.52264669
32JAK31.51730251
33TESK11.41720176
34MOS1.41273696
35MAP3K141.40745536
36MAP4K21.35811483
37TXK1.30227130
38ACVR1B1.30202707
39LATS21.28918233
40MAPK151.25538211
41EIF2AK31.25326257
42CAMK1D1.23026614
43IRAK41.23002295
44CSF1R1.19048749
45CDK91.18685906
46DDR21.18613296
47PLK41.18441942
48CAMK1G1.17336728
49MAPK71.17032337
50STK101.16235136
51SIK21.15803909
52BCR1.13960284
53GRK71.13449956
54CDK41.12332201
55KIT1.11847213
56CHEK21.09310487
57IKBKE1.09271149
58RIPK11.09041758
59ZAP701.08942555
60ERBB31.08191766
61FRK1.07824391
62STK41.07770236
63SGK31.06802384
64CHEK11.06728528
65MAP3K41.06584158
66MAP2K31.06391918
67DYRK1B1.04835877
68STK241.03439680
69ATR1.03327626
70PIK3CA1.02925842
71DMPK1.02914548
72BTK1.00356156
73TTN0.99505554
74FGFR30.96840837
75SGK2230.96726076
76SGK4940.96726076
77TRPM70.96414256
78RIPK40.96104511
79STK38L0.95816931
80PIM10.95099159
81TYK20.94482960
82ATM0.94049918
83TGFBR10.93406206
84LATS10.92079592
85PLK10.91067232
86CHUK0.90609526
87FLT30.88279723
88WNK30.87891910
89NLK0.87567802
90CDK70.87020985
91BMPR20.84843530
92TNIK0.84434170
93SRPK10.83098324
94PKN10.81288714
95TBK10.80686158
96MAP3K130.80007236
97CLK10.79677523
98YES10.79613771
99MELK0.78775448
100ITK0.77882358
101MATK0.77074970
102AURKB0.76285158
103MKNK10.75564466
104SIK30.75189141
105PDGFRB0.73874816
106FER0.73469965
107MTOR0.73192580
108IKBKB0.71334276
109BRD40.71230407
110PLK30.70363039
111TGFBR20.69811338
112CCNB10.69373432
113TTK0.69245360
114PDK10.68599034
115DAPK20.68361272
116PKN20.67504353
117CSK0.67417090
118TEC0.64949516
119MAPK130.64927276
120BUB10.64275521
121PIK3CG0.63849258
122CDK20.63824003
123BLK0.62646342
124TAOK10.62606811
125BRSK10.61412691
126MAP3K50.60164309
127IRAK30.60126930
128PIM20.58602509
129CAMK40.58118244
130BMPR1B0.58087804
131STK380.57526730
132PRKD30.57350324
133PRKAA20.56904902
134HCK0.56586294
135PAK20.56563686
136MARK30.54846725
137MAP3K80.54004664
138NEK60.53340182
139JAK10.52828971
140MAP3K60.52313133
141MAP3K30.51061213
142RAF10.50839308
143TYRO30.50584327
144UHMK10.50187781
145LCK0.49415391
146PRKCE0.48602527
147WNK10.46188090
148IRAK20.45252999
149PTK60.43081541
150MAPK120.42708805
151KSR20.42342655
152PTK2B0.42046403
153PDGFRA0.41921363
154JAK20.41186730
155TAOK30.41157800
156EGFR0.40417668

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041102.11597916
2Fanconi anemia pathway_Homo sapiens_hsa034602.08166395
3Dorso-ventral axis formation_Homo sapiens_hsa043201.90978352
4Circadian rhythm_Homo sapiens_hsa047101.88368908
5Homologous recombination_Homo sapiens_hsa034401.82067086
6DNA replication_Homo sapiens_hsa030301.80923772
7Leishmaniasis_Homo sapiens_hsa051401.79697681
8Basal transcription factors_Homo sapiens_hsa030221.76129330
9NF-kappa B signaling pathway_Homo sapiens_hsa040641.73988394
10mRNA surveillance pathway_Homo sapiens_hsa030151.72490608
11B cell receptor signaling pathway_Homo sapiens_hsa046621.67216585
12Herpes simplex infection_Homo sapiens_hsa051681.65600326
13Osteoclast differentiation_Homo sapiens_hsa043801.59338863
14RNA transport_Homo sapiens_hsa030131.59188826
15Antigen processing and presentation_Homo sapiens_hsa046121.59021690
16Renal cell carcinoma_Homo sapiens_hsa052111.56647758
17Transcriptional misregulation in cancer_Homo sapiens_hsa052021.48228723
18Measles_Homo sapiens_hsa051621.48224384
19p53 signaling pathway_Homo sapiens_hsa041151.46676836
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.40768899
21Mismatch repair_Homo sapiens_hsa034301.38452300
22Chronic myeloid leukemia_Homo sapiens_hsa052201.38257322
23Toxoplasmosis_Homo sapiens_hsa051451.37920377
24Influenza A_Homo sapiens_hsa051641.29268805
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.28327067
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.26013500
27Pancreatic cancer_Homo sapiens_hsa052121.24410958
28Small cell lung cancer_Homo sapiens_hsa052221.23654589
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.23211680
30Hepatitis B_Homo sapiens_hsa051611.22034403
31Legionellosis_Homo sapiens_hsa051341.21094798
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.20777544
33Spliceosome_Homo sapiens_hsa030401.20311271
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.20017837
35Colorectal cancer_Homo sapiens_hsa052101.19692044
36MicroRNAs in cancer_Homo sapiens_hsa052061.18973787
37RNA degradation_Homo sapiens_hsa030181.18051300
38NOD-like receptor signaling pathway_Homo sapiens_hsa046211.17601268
39Viral carcinogenesis_Homo sapiens_hsa052031.13426235
40Base excision repair_Homo sapiens_hsa034101.12240823
41Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.11956178
42Oocyte meiosis_Homo sapiens_hsa041141.11578486
43TNF signaling pathway_Homo sapiens_hsa046681.11368869
44T cell receptor signaling pathway_Homo sapiens_hsa046601.10158415
45African trypanosomiasis_Homo sapiens_hsa051431.09237629
46Primary immunodeficiency_Homo sapiens_hsa053401.07397936
47ErbB signaling pathway_Homo sapiens_hsa040121.06996697
48Epstein-Barr virus infection_Homo sapiens_hsa051691.06425104
49Shigellosis_Homo sapiens_hsa051311.06202736
50HTLV-I infection_Homo sapiens_hsa051661.04550838
51Jak-STAT signaling pathway_Homo sapiens_hsa046301.04271014
52Acute myeloid leukemia_Homo sapiens_hsa052211.03900938
53Thyroid cancer_Homo sapiens_hsa052161.03244694
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02474527
55Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.02009172
56Type II diabetes mellitus_Homo sapiens_hsa049300.99737414
57Adherens junction_Homo sapiens_hsa045200.97341415
58Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.96169750
59Amoebiasis_Homo sapiens_hsa051460.94895021
60Estrogen signaling pathway_Homo sapiens_hsa049150.91882561
61Apoptosis_Homo sapiens_hsa042100.91425914
62Tuberculosis_Homo sapiens_hsa051520.91103725
63FoxO signaling pathway_Homo sapiens_hsa040680.89842613
64Long-term depression_Homo sapiens_hsa047300.88494903
65Non-homologous end-joining_Homo sapiens_hsa034500.88384187
66Non-small cell lung cancer_Homo sapiens_hsa052230.87803864
67Dilated cardiomyopathy_Homo sapiens_hsa054140.87687070
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.87019793
69Long-term potentiation_Homo sapiens_hsa047200.86777421
70Renin secretion_Homo sapiens_hsa049240.86636533
71Nitrogen metabolism_Homo sapiens_hsa009100.86632346
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.86560031
73mTOR signaling pathway_Homo sapiens_hsa041500.86217635
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.85406035
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85302914
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84881030
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.84012800
78Salmonella infection_Homo sapiens_hsa051320.82928627
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.82760537
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.81989433
81Endometrial cancer_Homo sapiens_hsa052130.81796806
82Pertussis_Homo sapiens_hsa051330.81529876
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.81494467
84Nicotine addiction_Homo sapiens_hsa050330.81178440
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81146082
86Viral myocarditis_Homo sapiens_hsa054160.80657827
87Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.79320332
88Oxytocin signaling pathway_Homo sapiens_hsa049210.79094146
89Notch signaling pathway_Homo sapiens_hsa043300.78117851
90Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.78055335
91Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.78016334
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77964612
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77055754
94Vitamin B6 metabolism_Homo sapiens_hsa007500.77046353
95Rheumatoid arthritis_Homo sapiens_hsa053230.76533628
96GnRH signaling pathway_Homo sapiens_hsa049120.75791224
97Glioma_Homo sapiens_hsa052140.75352392
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75189172
99VEGF signaling pathway_Homo sapiens_hsa043700.74768720
100Chemokine signaling pathway_Homo sapiens_hsa040620.74279115
101Hematopoietic cell lineage_Homo sapiens_hsa046400.73569517
102Bladder cancer_Homo sapiens_hsa052190.73528350
103Prostate cancer_Homo sapiens_hsa052150.73037183
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72794940
105TGF-beta signaling pathway_Homo sapiens_hsa043500.71907712
106cAMP signaling pathway_Homo sapiens_hsa040240.70304968
107Inositol phosphate metabolism_Homo sapiens_hsa005620.70302226
108Prolactin signaling pathway_Homo sapiens_hsa049170.70154147
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67933857
110Choline metabolism in cancer_Homo sapiens_hsa052310.66757057
111Platelet activation_Homo sapiens_hsa046110.66599744
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65819744
113Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65679069
114Cocaine addiction_Homo sapiens_hsa050300.65612308
115Morphine addiction_Homo sapiens_hsa050320.65445947
116Lysine degradation_Homo sapiens_hsa003100.65360332
117Pathways in cancer_Homo sapiens_hsa052000.65186295
118Staphylococcus aureus infection_Homo sapiens_hsa051500.65094217
119Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65044057
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.64455772
121Insulin signaling pathway_Homo sapiens_hsa049100.64381578
122Proteoglycans in cancer_Homo sapiens_hsa052050.63276552
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.62760260
124Glutamatergic synapse_Homo sapiens_hsa047240.62612412
125Fatty acid biosynthesis_Homo sapiens_hsa000610.61953170
126Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61775166
127Nucleotide excision repair_Homo sapiens_hsa034200.60405210
128Salivary secretion_Homo sapiens_hsa049700.60364469
129GABAergic synapse_Homo sapiens_hsa047270.59912895
130Malaria_Homo sapiens_hsa051440.58685985
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57330168
132Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57208418
133Hepatitis C_Homo sapiens_hsa051600.56646958
134Amphetamine addiction_Homo sapiens_hsa050310.56643298
135HIF-1 signaling pathway_Homo sapiens_hsa040660.56399990
136Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56284384
137Graft-versus-host disease_Homo sapiens_hsa053320.55662482
138AMPK signaling pathway_Homo sapiens_hsa041520.55395960
139Cholinergic synapse_Homo sapiens_hsa047250.55314881
140Calcium signaling pathway_Homo sapiens_hsa040200.54909774
141Focal adhesion_Homo sapiens_hsa045100.54814165
142Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53626707
143Dopaminergic synapse_Homo sapiens_hsa047280.53228390
144PPAR signaling pathway_Homo sapiens_hsa033200.52393723
145Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52291573
146Central carbon metabolism in cancer_Homo sapiens_hsa052300.51000154
147MAPK signaling pathway_Homo sapiens_hsa040100.48735683
148Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48549565
149Hippo signaling pathway_Homo sapiens_hsa043900.48535368
150Insulin resistance_Homo sapiens_hsa049310.46968363

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »