ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	homocysteine metabolic process (GO:0050667)	8.32510550
2	cytidine metabolic process (GO:0046087)	8.27153750
3	cytidine catabolic process (GO:0006216)	8.27153750
4	cytidine deamination (GO:0009972)	8.27153750
5	folic acid-containing compound biosynthetic process (GO:0009396)	7.33847698
6	pyrimidine ribonucleoside catabolic process (GO:0046133)	7.22436234
7	regulation of plasminogen activation (GO:0010755)	7.17732955
8	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	6.52955334
9	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	6.52955334
10	sulfur amino acid catabolic process (GO:0000098)	6.25679958
11	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	6.10598838
12	microtubule nucleation (GO:0007020)	5.95505968
13	regulation of activation of Janus kinase activity (GO:0010533)	5.71444490
14	DNA deamination (GO:0045006)	5.55307748
15	purine nucleotide salvage (GO:0032261)	5.41360224
16	cysteine metabolic process (GO:0006534)	5.31117998
17	desmosome organization (GO:0002934)	5.28563072
18	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	5.12986695
19	negative regulation of DNA biosynthetic process (GO:2000279)	5.07497818
20	pteridine-containing compound biosynthetic process (GO:0042559)	4.86560429
21	adenosine metabolic process (GO:0046085)	4.82590816
22	white fat cell differentiation (GO:0050872)	4.73589016
23	regulation of tight junction assembly (GO:2000810)	4.63473983
24	positive regulation of endothelial cell differentiation (GO:0045603)	4.58033456
25	eosinophil chemotaxis (GO:0048245)	4.45691301
26	regulation of chemokine-mediated signaling pathway (GO:0070099)	4.40530400
27	cell migration involved in heart development (GO:0060973)	4.40019429
28	galactose catabolic process (GO:0019388)	4.38325558
29	negative regulation by host of viral transcription (GO:0043922)	4.35496713
30	galactose metabolic process (GO:0006012)	4.34358592
31	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.25423631
32	alternative mRNA splicing, via spliceosome (GO:0000380)	4.21033837
33	IMP biosynthetic process (GO:0006188)	4.19639721
34	primary amino compound metabolic process (GO:1901160)	4.15333030
35	positive regulation of interleukin-8 secretion (GO:2000484)	4.07592210
36	polyamine biosynthetic process (GO:0006596)	4.03710702
37	inner mitochondrial membrane organization (GO:0007007)	4.01450922
38	regulation of gonadotropin secretion (GO:0032276)	3.99408049
39	eosinophil migration (GO:0072677)	3.98532516
40	regulation of vitamin D biosynthetic process (GO:0060556)	3.95310061
41	protein-chromophore linkage (GO:0018298)	3.90212837
42	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.88212957
43	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.88212957
44	NADH dehydrogenase complex assembly (GO:0010257)	3.88212957
45	regulation of sequestering of triglyceride (GO:0010889)	3.87400418
46	negative regulation of catenin import into nucleus (GO:0035414)	3.85754007
47	phosphatidylglycerol biosynthetic process (GO:0006655)	3.83024967
48	L-serine metabolic process (GO:0006563)	3.81438883
49	histone H4-K12 acetylation (GO:0043983)	3.74148172
50	regulation of branching involved in salivary gland morphogenesis (GO:0060693)	3.74023273
51	cartilage morphogenesis (GO:0060536)	3.72754044
52	tRNA modification (GO:0006400)	3.70341695
53	negative regulation of keratinocyte proliferation (GO:0010839)	3.59948567
54	protein-cofactor linkage (GO:0018065)	3.59668404
55	regulation of endothelial cell differentiation (GO:0045601)	3.57214356
56	organic cation transport (GO:0015695)	3.50455119
57	negative regulation of Ras GTPase activity (GO:0034261)	3.46551840
58	pseudouridine synthesis (GO:0001522)	3.43153116
59	cochlea development (GO:0090102)	3.41282982
60	positive regulation of monocyte chemotaxis (GO:0090026)	3.41074584
61	inner ear receptor cell development (GO:0060119)	3.37543202
62	behavioral defense response (GO:0002209)	3.37307543
63	behavioral fear response (GO:0001662)	3.37307543
64	mitochondrial RNA metabolic process (GO:0000959)	3.36340543
65	pyrimidine nucleoside catabolic process (GO:0046135)	3.36095884
66	IMP metabolic process (GO:0046040)	3.34285901
67	rRNA methylation (GO:0031167)	3.32761083
68	DNA dealkylation (GO:0035510)	3.22949294
69	sulfur amino acid biosynthetic process (GO:0000097)	3.21787264
70	polyamine metabolic process (GO:0006595)	3.20569496
71	tetrahydrofolate metabolic process (GO:0046653)	3.19272605
72	protein complex biogenesis (GO:0070271)	3.17805895
73	regulation of mononuclear cell migration (GO:0071675)	3.13194228
74	negative regulation of viral transcription (GO:0032897)	3.09775206
75	GTP biosynthetic process (GO:0006183)	3.09025766
76	regulation of vitamin metabolic process (GO:0030656)	3.06692150
77	innervation (GO:0060384)	3.05451957
78	cellular biogenic amine biosynthetic process (GO:0042401)	3.03718373
79	DNA demethylation (GO:0080111)	3.03630073
80	positive regulation of B cell differentiation (GO:0045579)	3.03113796
81	growth hormone secretion (GO:0030252)	3.01893041
82	regulation of chronic inflammatory response (GO:0002676)	3.01856239
83	folic acid-containing compound metabolic process (GO:0006760)	3.01329751
84	negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)	2.98695775
85	rRNA modification (GO:0000154)	2.98300705
86	platelet dense granule organization (GO:0060155)	2.95380875
87	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.94924966
88	serine family amino acid biosynthetic process (GO:0009070)	2.94461783
89	fear response (GO:0042596)	2.89906014
90	modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)	2.89901121
91	pyrimidine ribonucleoside metabolic process (GO:0046131)	2.89729423
92	response to vitamin A (GO:0033189)	2.89312842
93	ribosome biogenesis (GO:0042254)	2.85760351
94	response to caffeine (GO:0031000)	2.84356413
95	guanosine-containing compound biosynthetic process (GO:1901070)	2.84053483
96	regulation of T cell chemotaxis (GO:0010819)	2.83943953
97	positive regulation of T cell chemotaxis (GO:0010820)	2.83943953
98	amine biosynthetic process (GO:0009309)	2.81898940
99	chaperone-mediated protein transport (GO:0072321)	2.81293189
100	regulation of macrophage chemotaxis (GO:0010758)	2.80693481

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	3.16162991
2	VDR_22108803_ChIP-Seq_LS180_Human	2.81205311
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.77078816
4	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.57846962
5	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	2.57721780
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.55733504
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.38666060
8	EZH2_22144423_ChIP-Seq_EOC_Human	2.34850712
9	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.32918716
10	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.30417284
11	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.10839511
12	YY1_22570637_ChIP-Seq_MALME-3M_Human	2.07624228
13	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.07009725
14	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.06604845
15	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	12.7556842
16	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.98046955
17	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.93463126
18	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.77882661
19	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.71446627
20	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.69060339
21	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.68071163
22	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.65914242
23	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.47583133
24	GATA1_22025678_ChIP-Seq_K562_Human	1.47417807
25	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.45674003
26	TP53_22573176_ChIP-Seq_HFKS_Human	1.43101758
27	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.41500525
28	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.39669321
29	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.38180299
30	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.36373152
31	FOXP3_21729870_ChIP-Seq_TREG_Human	1.34814499
32	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.34532505
33	NCOR_22424771_ChIP-Seq_293T_Human	1.33179471
34	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.30580303
35	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.28136987
36	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.27945518
37	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.25393845
38	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.23752788
39	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.22984554
40	TAF2_19829295_ChIP-Seq_ESCs_Human	1.20617386
41	CDX2_22108803_ChIP-Seq_LS180_Human	1.20258834
42	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.17349050
43	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.15268242
44	P300_27268052_Chip-Seq_Bcells_Human	1.15014794
45	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.13846141
46	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.12120406
47	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.10742467
48	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.09732073
49	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.09107250
50	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.07016787
51	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.07016787
52	NANOG_20526341_ChIP-Seq_ESCs_Human	1.05493295
53	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.05378441
54	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.05256630
55	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.04900733
56	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.04433627
57	STAT1_20625510_ChIP-Seq_HELA_Human	1.02327101
58	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.02146555
59	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.01962907
60	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.01665356
61	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.00355259
62	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.99975334
63	BCAT_22108803_ChIP-Seq_LS180_Human	0.98477493
64	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.97055884
65	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.95729747
66	GBX2_23144817_ChIP-Seq_PC3_Human	0.94154725
67	GATA3_26560356_Chip-Seq_TH1_Human	0.93346288
68	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.93319557
69	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.92963216
70	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.92629707
71	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.92524089
72	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.90383474
73	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.90237674
74	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.88787107
75	RXR_22108803_ChIP-Seq_LS180_Human	0.88646082
76	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.86994729
77	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.86209411
78	OCT4_20526341_ChIP-Seq_ESCs_Human	0.85759234
79	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.84792880
80	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.82085422
81	P68_20966046_ChIP-Seq_HELA_Human	0.81543399
82	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.80262721
83	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.79867802
84	EWS_26573619_Chip-Seq_HEK293_Human	0.79862660
85	NANOG_19829295_ChIP-Seq_ESCs_Human	0.79710602
86	SOX2_19829295_ChIP-Seq_ESCs_Human	0.79710602
87	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.79274221
88	P300_19829295_ChIP-Seq_ESCs_Human	0.79236990
89	VDR_23849224_ChIP-Seq_CD4+_Human	0.78439430
90	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.77680902
91	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.76741912
92	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.76439858
93	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.76402768
94	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.76292884
95	PHF8_20622853_ChIP-Seq_HELA_Human	0.76186306
96	FLI1_21867929_ChIP-Seq_CD8_Mouse	0.75492582
97	GABP_19822575_ChIP-Seq_HepG2_Human	0.74297265
98	CTCF_20526341_ChIP-Seq_ESCs_Human	0.74255534
99	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.74227835
100	CBP_20019798_ChIP-Seq_JUKART_Human	0.72456009

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005670_abnormal_white_adipose	5.84965777
2	MP0003183_abnormal_peptide_metabolism	4.64213048
3	MP0005646_abnormal_pituitary_gland	4.02643464
4	MP0005360_urolithiasis	3.96501081
5	MP0001661_extended_life_span	3.91655358
6	MP0000013_abnormal_adipose_tissue	3.49449362
7	MP0008995_early_reproductive_senescence	3.43294371
8	MP0003705_abnormal_hypodermis_morpholog	2.75932865
9	MP0002736_abnormal_nociception_after	2.61954189
10	MP0002938_white_spotting	2.45408580
11	MP0005671_abnormal_response_to	2.17563546
12	MP0004147_increased_porphyrin_level	2.12207027
13	MP0002735_abnormal_chemical_nociception	2.10776348
14	MP0002138_abnormal_hepatobiliary_system	2.07719866
15	MP0000751_myopathy	2.05645709
16	MP0004885_abnormal_endolymph	1.95976953
17	MP0000003_abnormal_adipose_tissue	1.85846535
18	MP0004185_abnormal_adipocyte_glucose	1.81664417
19	MP0006276_abnormal_autonomic_nervous	1.81584884
20	MP0005253_abnormal_eye_physiology	1.79560640
21	MP0000566_synostosis	1.71924401
22	MP0003786_premature_aging	1.69793997
23	MP0002095_abnormal_skin_pigmentation	1.68526153
24	MP0001764_abnormal_homeostasis	1.66166517
25	MP0004130_abnormal_muscle_cell	1.64933320
26	MP0005367_renal/urinary_system_phenotyp	1.62370845
27	MP0000516_abnormal_urinary_system	1.62370845
28	MP0001968_abnormal_touch/_nociception	1.62202280
29	MP0005332_abnormal_amino_acid	1.56192465
30	MP0003724_increased_susceptibility_to	1.55486526
31	MP0008872_abnormal_physiological_respon	1.55134951
32	MP0000750_abnormal_muscle_regeneration	1.50261446
33	MP0009333_abnormal_splenocyte_physiolog	1.48301157
34	MP0003186_abnormal_redox_activity	1.41508939
35	MP0001486_abnormal_startle_reflex	1.40672076
36	MP0004215_abnormal_myocardial_fiber	1.30814359
37	MP0000534_abnormal_ureter_morphology	1.28625536
38	MP0004043_abnormal_pH_regulation	1.24591008
39	MP0002837_dystrophic_cardiac_calcinosis	1.21706613
40	MP0002269_muscular_atrophy	1.21033833
41	MP0002102_abnormal_ear_morphology	1.19524709
42	MP0001919_abnormal_reproductive_system	1.13989015
43	MP0009765_abnormal_xenobiotic_induced	1.13829332
44	MP0003880_abnormal_central_pattern	1.09053982
45	MP0000026_abnormal_inner_ear	1.08838115
46	MP0005423_abnormal_somatic_nervous	1.08188698
47	MP0002148_abnormal_hypersensitivity_rea	1.06872657
48	MP0000749_muscle_degeneration	1.05305281
49	MP0005551_abnormal_eye_electrophysiolog	1.03871505
50	MP0001440_abnormal_grooming_behavior	1.02625651
51	MP0000631_abnormal_neuroendocrine_gland	0.98752707
52	MP0000647_abnormal_sebaceous_gland	0.98653258
53	MP0006292_abnormal_olfactory_placode	0.97908346
54	MP0000049_abnormal_middle_ear	0.97563965
55	MP0002160_abnormal_reproductive_system	0.95993319
56	MP0005389_reproductive_system_phenotype	0.95482972
57	MP0002396_abnormal_hematopoietic_system	0.94615136
58	MP0006072_abnormal_retinal_apoptosis	0.94589941
59	MP0003137_abnormal_impulse_conducting	0.92246659
60	MP0009763_increased_sensitivity_to	0.90777588
61	MP0003693_abnormal_embryo_hatching	0.87777510
62	MP0008058_abnormal_DNA_repair	0.86898822
63	MP0001963_abnormal_hearing_physiology	0.81360183
64	MP0002069_abnormal_eating/drinking_beha	0.80059450
65	MP0001905_abnormal_dopamine_level	0.79924887
66	MP0003806_abnormal_nucleotide_metabolis	0.79491236
67	MP0003646_muscle_fatigue	0.78387220
68	MP0000703_abnormal_thymus_morphology	0.77544836
69	MP0005171_absent_coat_pigmentation	0.75871377
70	MP0009643_abnormal_urine_homeostasis	0.75662461
71	MP0000747_muscle_weakness	0.75603217
72	MP0005377_hearing/vestibular/ear_phenot	0.73664836
73	MP0003878_abnormal_ear_physiology	0.73664836
74	MP0009115_abnormal_fat_cell	0.72869123
75	MP0004133_heterotaxia	0.70602198
76	MP0000762_abnormal_tongue_morphology	0.70338302
77	MP0001270_distended_abdomen	0.69542571
78	MP0008873_increased_physiological_sensi	0.67831236
79	MP0001502_abnormal_circadian_rhythm	0.66580326
80	MP0009745_abnormal_behavioral_response	0.65812150
81	MP0002127_abnormal_cardiovascular_syste	0.65784121
82	MP0005000_abnormal_immune_tolerance	0.64868382
83	MP0000639_abnormal_adrenal_gland	0.64772126
84	MP0005376_homeostasis/metabolism_phenot	0.64746392
85	MP0001756_abnormal_urination	0.63625861
86	MP0004134_abnormal_chest_morphology	0.62127964
87	MP0001944_abnormal_pancreas_morphology	0.62097284
88	MP0005636_abnormal_mineral_homeostasis	0.61700033
89	MP0005623_abnormal_meninges_morphology	0.61484257
90	MP0003045_fibrosis	0.61143291
91	MP0005084_abnormal_gallbladder_morpholo	0.60768420
92	MP0002972_abnormal_cardiac_muscle	0.60323237
93	MP0002295_abnormal_pulmonary_circulatio	0.58922488
94	MP0004142_abnormal_muscle_tone	0.58468126
95	MP0000920_abnormal_myelination	0.58084872
96	MP0002210_abnormal_sex_determination	0.57639780
97	MP0000653_abnormal_sex_gland	0.57537744
98	MP0003763_abnormal_thymus_physiology	0.55878130
99	MP0004484_altered_response_of	0.55717733
100	MP0005410_abnormal_fertilization	0.54490296

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	8.64010588
2	Abnormality of alanine metabolism (HP:0010916)	8.64010588
3	Hyperalaninemia (HP:0003348)	8.64010588
4	Congenital sensorineural hearing impairment (HP:0008527)	5.78945306
5	Constricted visual fields (HP:0001133)	5.73049924
6	Abnormality of the fetal cardiovascular system (HP:0010948)	4.84285686
7	Abnormal umbilical cord blood vessels (HP:0011403)	4.84285686
8	Single umbilical artery (HP:0001195)	4.84285686
9	Spontaneous hematomas (HP:0007420)	4.80114323
10	Decreased electroretinogram (ERG) amplitude (HP:0000654)	4.70446137
11	Esophageal varix (HP:0002040)	4.29756252
12	Patchy hypopigmentation of hair (HP:0011365)	4.15627768
13	White forelock (HP:0002211)	4.13173958
14	Birth length less than 3rd percentile (HP:0003561)	3.90420065
15	Conjunctival telangiectasia (HP:0000524)	3.71035015
16	Oligomenorrhea (HP:0000876)	3.59022186
17	Action tremor (HP:0002345)	3.49492313
18	Homocystinuria (HP:0002156)	3.47388397
19	Abnormality of homocysteine metabolism (HP:0010919)	3.47388397
20	Myocardial infarction (HP:0001658)	3.41382492
21	T lymphocytopenia (HP:0005403)	3.29094464
22	Anorexia (HP:0002039)	3.27831696
23	Abnormality of the umbilical cord (HP:0010881)	3.21782307
24	Attenuation of retinal blood vessels (HP:0007843)	3.16117418
25	Abnormality of serum amino acid levels (HP:0003112)	3.06489453
26	Pendular nystagmus (HP:0012043)	2.99697009
27	Aplastic anemia (HP:0001915)	2.96954964
28	Abnormality of the vasculature of the conjunctiva (HP:0008054)	2.88697233
29	Pigmentary retinal degeneration (HP:0001146)	2.82930664
30	Abnormality of T cell number (HP:0011839)	2.77427127
31	Maternal diabetes (HP:0009800)	2.73445271
32	Hypoplastic left heart (HP:0004383)	2.69623722
33	Conjugated hyperbilirubinemia (HP:0002908)	2.66354830
34	Chronic otitis media (HP:0000389)	2.62313873
35	Cutaneous melanoma (HP:0012056)	2.59103755
36	Cavernous hemangioma (HP:0001048)	2.54692327
37	Heterochromia iridis (HP:0001100)	2.47910093
38	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.45035278
39	Pulmonary embolism (HP:0002204)	2.41864945
40	Carpal bone hypoplasia (HP:0001498)	2.41776592
41	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.40857495
42	Visceral angiomatosis (HP:0100761)	2.33701873
43	Generalized aminoaciduria (HP:0002909)	2.31041595
44	Chronic hepatic failure (HP:0100626)	2.29227200
45	Short tibia (HP:0005736)	2.28948441
46	Decreased subcutaneous fat (HP:0001002)	2.26591585
47	Hypoalphalipoproteinemia (HP:0003233)	2.25659552
48	Palpitations (HP:0001962)	2.25365899
49	Chorioretinal atrophy (HP:0000533)	2.25185303
50	Reduced subcutaneous adipose tissue (HP:0003758)	2.21581568
51	Poor speech (HP:0002465)	2.19483999
52	Abolished electroretinogram (ERG) (HP:0000550)	2.17020551
53	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.14030971
54	Biconcave vertebral bodies (HP:0004586)	2.13588831
55	Syncope (HP:0001279)	2.11251902
56	Hypoplastic heart (HP:0001961)	2.11198806
57	Sudden death (HP:0001699)	2.10474166
58	Premature graying of hair (HP:0002216)	2.05907286
59	Toxemia of pregnancy (HP:0100603)	2.03761169
60	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.01174872
61	Nausea (HP:0002018)	2.00581901
62	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.00274441
63	Hepatocellular necrosis (HP:0001404)	1.99709712
64	Arteriovenous malformation (HP:0100026)	1.99412562
65	Hemangiomatosis (HP:0007461)	1.99115209
66	Myopathic facies (HP:0002058)	1.98734157
67	Increased serum pyruvate (HP:0003542)	1.98329848
68	Fatigue (HP:0012378)	1.97779414
69	Insulin-resistant diabetes mellitus (HP:0000831)	1.96995284
70	Pustule (HP:0200039)	1.92436123
71	Abnormalities of placenta or umbilical cord (HP:0001194)	1.88639248
72	Thrombophlebitis (HP:0004418)	1.83796780
73	Increased purine levels (HP:0004368)	1.79797269
74	Hyperuricemia (HP:0002149)	1.79797269
75	Increased corneal curvature (HP:0100692)	1.79605615
76	Keratoconus (HP:0000563)	1.79605615
77	Aplasia/hypoplasia of the uterus (HP:0008684)	1.79542498
78	Granulocytopenia (HP:0001913)	1.78946563
79	Oral leukoplakia (HP:0002745)	1.78677709
80	Abnormal tarsal ossification (HP:0008369)	1.78497304
81	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.75139760
82	Abnormality of glycolysis (HP:0004366)	1.75038946
83	Ileus (HP:0002595)	1.74735958
84	Abnormality of subcutaneous fat tissue (HP:0001001)	1.73871970
85	Delayed CNS myelination (HP:0002188)	1.71772447
86	Abnormality of eosinophils (HP:0001879)	1.71771687
87	Type 2 muscle fiber atrophy (HP:0003554)	1.71387677
88	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.71064657
89	Abnormality of T cells (HP:0002843)	1.67497978
90	Abnormality of the phalanges of the hallux (HP:0010057)	1.67094368
91	Abnormality of fatty-acid metabolism (HP:0004359)	1.65497622
92	Progressive cerebellar ataxia (HP:0002073)	1.65468361
93	Increased serum lactate (HP:0002151)	1.64937293
94	Myokymia (HP:0002411)	1.62538404
95	Methylmalonic acidemia (HP:0002912)	1.60380550
96	Atrial fibrillation (HP:0005110)	1.59803740
97	Metabolic acidosis (HP:0001942)	1.59754152
98	Hypopigmentation of the fundus (HP:0007894)	1.57764016
99	Supernumerary spleens (HP:0009799)	1.57363436
100	Abnormality of the labia minora (HP:0012880)	1.55325947

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.94810548
2	MAP3K3	3.48974136
3	MAP2K3	3.14303280
4	DAPK2	3.07647280
5	ACVR1B	2.73495791
6	BUB1	2.67643479
7	CCNB1	2.62352933
8	JAK3	2.54786838
9	ZAK	2.44818746
10	BCKDK	2.42493262
11	NTRK2	2.42309025
12	CDK9	2.18325502
13	MAP2K7	2.17439941
14	MAP3K6	2.11154007
15	FGR	2.05201730
16	KDR	2.00409004
17	BLK	1.93230933
18	LMTK2	1.91055437
19	TXK	1.89431900
20	SGK223	1.83289869
21	SGK494	1.83289869
22	MAP3K11	1.65473749
23	RPS6KB2	1.58096036
24	ADRBK2	1.56236563
25	NME2	1.45891696
26	ARAF	1.43748109
27	EIF2AK3	1.42289759
28	AURKA	1.41390204
29	PDK2	1.40771774
30	VRK2	1.39858499
31	PIM2	1.36380231
32	TYRO3	1.33690236
33	MAP4K1	1.32384619
34	MST4	1.27483488
35	OBSCN	1.21071702
36	WNK4	1.19035707
37	SGK2	1.15192377
38	EPHB2	1.12522952
39	PIK3CA	1.07905949
40	TESK2	1.03498753
41	FGFR1	1.03081166
42	MUSK	1.01986449
43	SRPK1	0.98128983
44	CSNK1A1	0.92477411
45	NEK6	0.90189681
46	RPS6KB1	0.87516416
47	ITK	0.87461269
48	CAMK2D	0.87359812
49	GRK1	0.86522750
50	NEK1	0.85294878
51	ADRBK1	0.81372906
52	SGK3	0.79925037
53	NUAK1	0.77294417
54	PLK4	0.74377785
55	INSRR	0.74104557
56	MARK1	0.72361750
57	VRK1	0.71632007
58	PHKG2	0.71565470
59	PHKG1	0.71565470
60	FRK	0.68481695
61	MYLK	0.66092354
62	LCK	0.65951943
63	GRK7	0.64861481
64	TESK1	0.64644864
65	NME1	0.64150047
66	PLK2	0.64003741
67	CAMK2B	0.63252414
68	CHEK2	0.62706973
69	BRSK1	0.62262572
70	LIMK1	0.58837757
71	MAPKAPK5	0.56757670
72	DAPK1	0.56358033
73	PRKCI	0.55384092
74	CAMK1	0.55332315
75	CAMK2A	0.55298346
76	ATR	0.54574072
77	PRKCQ	0.53684314
78	PRKCE	0.53031235
79	CDC7	0.52782106
80	NTRK3	0.50472619
81	TRIM28	0.50428270
82	FES	0.48959693
83	PIM1	0.48246862
84	SYK	0.47684349
85	PRKACA	0.46599029
86	INSR	0.46049867
87	CAMK2G	0.44867336
88	PRKCD	0.44674852
89	MAP3K7	0.44402547
90	CAMKK2	0.43743978
91	STK16	0.41718223
92	PLK3	0.41166996
93	DYRK2	0.40227170
94	WNK3	0.40064201
95	FYN	0.38683635
96	GRK5	0.38522678
97	CSNK1G3	0.37831883
98	CDK7	0.37587562
99	PRKCA	0.36916563
100	PRKD1	0.36558876

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.32987989
2	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	3.55518151
3	One carbon pool by folate_Homo sapiens_hsa00670	3.40677997
4	Arginine biosynthesis_Homo sapiens_hsa00220	2.86604710
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.51239321
6	Collecting duct acid secretion_Homo sapiens_hsa04966	2.47790777
7	Sulfur metabolism_Homo sapiens_hsa00920	2.35122666
8	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.33647877
9	Morphine addiction_Homo sapiens_hsa05032	2.08779966
10	GABAergic synapse_Homo sapiens_hsa04727	2.05506610
11	Sulfur relay system_Homo sapiens_hsa04122	2.03099700
12	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.95025971
13	Parkinsons disease_Homo sapiens_hsa05012	1.93179941
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.92101992
15	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.86839942
16	DNA replication_Homo sapiens_hsa03030	1.78264039
17	Antigen processing and presentation_Homo sapiens_hsa04612	1.74390288
18	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.60804834
19	Regulation of autophagy_Homo sapiens_hsa04140	1.52641285
20	Base excision repair_Homo sapiens_hsa03410	1.51023532
21	Nicotine addiction_Homo sapiens_hsa05033	1.49185251
22	Selenocompound metabolism_Homo sapiens_hsa00450	1.48898778
23	Galactose metabolism_Homo sapiens_hsa00052	1.41620642
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.40019889
25	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.39494113
26	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.39023404
27	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.38736200
28	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.35997205
29	Alzheimers disease_Homo sapiens_hsa05010	1.33526134
30	Rheumatoid arthritis_Homo sapiens_hsa05323	1.32205816
31	Peroxisome_Homo sapiens_hsa04146	1.19451332
32	Primary immunodeficiency_Homo sapiens_hsa05340	1.19121075
33	Huntingtons disease_Homo sapiens_hsa05016	1.17052358
34	Serotonergic synapse_Homo sapiens_hsa04726	1.16347719
35	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.13520434
36	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.09022950
37	RNA polymerase_Homo sapiens_hsa03020	1.08747178
38	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.06751997
39	Fatty acid elongation_Homo sapiens_hsa00062	1.06482023
40	Graft-versus-host disease_Homo sapiens_hsa05332	1.06264668
41	Circadian entrainment_Homo sapiens_hsa04713	1.04279220
42	Glutamatergic synapse_Homo sapiens_hsa04724	1.03893407
43	Butanoate metabolism_Homo sapiens_hsa00650	1.02518786
44	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.99563017
45	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.98334492
46	Cholinergic synapse_Homo sapiens_hsa04725	0.95919240
47	Dopaminergic synapse_Homo sapiens_hsa04728	0.95657812
48	Ether lipid metabolism_Homo sapiens_hsa00565	0.94187948
49	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.94095278
50	Vibrio cholerae infection_Homo sapiens_hsa05110	0.93359727
51	Prion diseases_Homo sapiens_hsa05020	0.92676665
52	Non-homologous end-joining_Homo sapiens_hsa03450	0.89747238
53	Alcoholism_Homo sapiens_hsa05034	0.89474819
54	Taste transduction_Homo sapiens_hsa04742	0.88262473
55	Carbon metabolism_Homo sapiens_hsa01200	0.87226425
56	Retinol metabolism_Homo sapiens_hsa00830	0.86713018
57	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.81953768
58	Caffeine metabolism_Homo sapiens_hsa00232	0.81951686
59	RNA transport_Homo sapiens_hsa03013	0.79911894
60	Cardiac muscle contraction_Homo sapiens_hsa04260	0.79453767
61	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.78291457
62	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.78082568
63	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.77862925
64	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.77776986
65	Arginine and proline metabolism_Homo sapiens_hsa00330	0.77530304
66	Type I diabetes mellitus_Homo sapiens_hsa04940	0.76913462
67	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.75464799
68	mRNA surveillance pathway_Homo sapiens_hsa03015	0.73515620
69	Allograft rejection_Homo sapiens_hsa05330	0.72857466
70	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.71618487
71	Olfactory transduction_Homo sapiens_hsa04740	0.71111840
72	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.69720790
73	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.64517704
74	Propanoate metabolism_Homo sapiens_hsa00640	0.62791049
75	Phenylalanine metabolism_Homo sapiens_hsa00360	0.62557309
76	Homologous recombination_Homo sapiens_hsa03440	0.58493635
77	Purine metabolism_Homo sapiens_hsa00230	0.57850931
78	Folate biosynthesis_Homo sapiens_hsa00790	0.57064366
79	Spliceosome_Homo sapiens_hsa03040	0.56932991
80	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.51480475
81	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.50233962
82	Metabolic pathways_Homo sapiens_hsa01100	0.49852629
83	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.48265511
84	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.48212788
85	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.46567605
86	Pyrimidine metabolism_Homo sapiens_hsa00240	0.45157855
87	RNA degradation_Homo sapiens_hsa03018	0.44749773
88	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.44485275
89	Fanconi anemia pathway_Homo sapiens_hsa03460	0.43504343
90	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.42755405
91	Nitrogen metabolism_Homo sapiens_hsa00910	0.40820953
92	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.40786246
93	Fat digestion and absorption_Homo sapiens_hsa04975	0.40675432
94	Tryptophan metabolism_Homo sapiens_hsa00380	0.38463950
95	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.36764878
96	Nucleotide excision repair_Homo sapiens_hsa03420	0.35278894
97	Chemical carcinogenesis_Homo sapiens_hsa05204	0.34416121
98	ABC transporters_Homo sapiens_hsa02010	0.27807550
99	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.27701457
100	Protein export_Homo sapiens_hsa03060	0.27160703

FEN1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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