FER

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the FPS/FES family of non-transmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome X. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1collagen fibril organization (GO:0030199)4.34151736
2chondrocyte proliferation (GO:0035988)4.24835270
3sequestering of extracellular ligand from receptor (GO:0035581)4.12805493
4presynaptic membrane assembly (GO:0097105)3.65976960
5detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.48760316
6COPI coating of Golgi vesicle (GO:0048205)3.42237917
7Golgi transport vesicle coating (GO:0048200)3.42237917
8paraxial mesoderm development (GO:0048339)3.41375827
9presynaptic membrane organization (GO:0097090)3.38923002
10mitotic sister chromatid cohesion (GO:0007064)3.36162192
11establishment of protein localization to Golgi (GO:0072600)3.34618937
12neural tube formation (GO:0001841)3.29373502
13hippo signaling (GO:0035329)3.26174741
14metanephric mesenchyme development (GO:0072075)3.23891850
15regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.15104884
16auditory behavior (GO:0031223)3.12231177
17central nervous system neuron axonogenesis (GO:0021955)3.10422580
18protein K11-linked deubiquitination (GO:0035871)3.06584030
19positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.06394950
20positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.06394950
21positive regulation of mitotic sister chromatid separation (GO:1901970)3.06394950
22axon extension involved in axon guidance (GO:0048846)3.02689169
23neuron projection extension involved in neuron projection guidance (GO:1902284)3.02689169
24central nervous system projection neuron axonogenesis (GO:0021952)3.02360474
25mesenchymal-epithelial cell signaling (GO:0060638)3.02179638
26regulation of tight junction assembly (GO:2000810)3.00075837
27negative regulation of cytosolic calcium ion concentration (GO:0051481)2.99175119
28interkinetic nuclear migration (GO:0022027)2.97546099
29kidney mesenchyme development (GO:0072074)2.96530680
30righting reflex (GO:0060013)2.92482104
31regulation of hippo signaling (GO:0035330)2.91571400
32regulation of pigment cell differentiation (GO:0050932)2.91219746
33epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.90613679
34craniofacial suture morphogenesis (GO:0097094)2.88866984
35protein heterotrimerization (GO:0070208)2.88403907
36negative regulation of DNA repair (GO:0045738)2.87564186
37neuronal action potential propagation (GO:0019227)2.85523902
38behavioral response to ethanol (GO:0048149)2.85076967
39smooth muscle tissue development (GO:0048745)2.83888722
40cell adhesion mediated by integrin (GO:0033627)2.83622119
41negative regulation of chondrocyte differentiation (GO:0032331)2.82874024
42cilium or flagellum-dependent cell motility (GO:0001539)2.82539591
43inner ear receptor stereocilium organization (GO:0060122)2.81550815
44ganglion development (GO:0061548)2.81097396
45regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.80822195
46apoptotic cell clearance (GO:0043277)2.74719067
47cilium assembly (GO:0042384)2.74717942
48pyrimidine nucleobase catabolic process (GO:0006208)2.74457917
49regulation of establishment of cell polarity (GO:2000114)2.74421578
50regulation of integrin-mediated signaling pathway (GO:2001044)2.74164259
51cilium organization (GO:0044782)2.73617477
52intraciliary transport (GO:0042073)2.73114425
53response to pheromone (GO:0019236)2.72475499
54regulation of centriole replication (GO:0046599)2.72065376
55regulation of sarcomere organization (GO:0060297)2.71843448
56atrial septum morphogenesis (GO:0060413)2.70886838
57protein targeting to Golgi (GO:0000042)2.70218709
58artery development (GO:0060840)2.68331669
59negative regulation of keratinocyte proliferation (GO:0010839)2.68024387
60extracellular negative regulation of signal transduction (GO:1900116)2.67607685
61extracellular regulation of signal transduction (GO:1900115)2.67607685
62pericardium development (GO:0060039)2.67331338
63mechanosensory behavior (GO:0007638)2.67318421
64male meiosis (GO:0007140)2.67063683
65fibroblast migration (GO:0010761)2.65628864
66cartilage morphogenesis (GO:0060536)2.64372035
67fucose catabolic process (GO:0019317)2.64218036
68L-fucose metabolic process (GO:0042354)2.64218036
69L-fucose catabolic process (GO:0042355)2.64218036
70lymphangiogenesis (GO:0001946)2.63607303
71tachykinin receptor signaling pathway (GO:0007217)2.63393092
72retinal ganglion cell axon guidance (GO:0031290)2.63332262
73gamma-aminobutyric acid transport (GO:0015812)2.63270053
74protein prenylation (GO:0018342)2.61853800
75prenylation (GO:0097354)2.61853800
76nucleus localization (GO:0051647)2.61630856
77negative regulation of organelle assembly (GO:1902116)2.61405763
78neurotransmitter-gated ion channel clustering (GO:0072578)2.61013387
79behavioral response to nicotine (GO:0035095)2.60995989
80axonal fasciculation (GO:0007413)2.60415812
81establishment of nucleus localization (GO:0040023)2.59310438
82retinal cone cell development (GO:0046549)2.59223000
83positive regulation of developmental pigmentation (GO:0048087)2.59192448
84negative regulation of axon guidance (GO:1902668)2.59189522
85appendage development (GO:0048736)2.57563962
86limb development (GO:0060173)2.57563962
87microtubule anchoring (GO:0034453)2.57528693
88retrograde transport, vesicle recycling within Golgi (GO:0000301)2.56091045
89detection of mechanical stimulus involved in sensory perception (GO:0050974)2.55809537
90postsynaptic membrane organization (GO:0001941)2.55028257
91photoreceptor cell maintenance (GO:0045494)2.53130493
92reflex (GO:0060004)2.52873482
93negative regulation of dendrite morphogenesis (GO:0050774)2.52379998
94outer ear morphogenesis (GO:0042473)2.51438326
95centriole replication (GO:0007099)2.50852761
96mitotic cytokinesis (GO:0000281)2.50707585
97DNA double-strand break processing (GO:0000729)2.50514326
98detection of light stimulus involved in sensory perception (GO:0050962)2.47784965
99detection of light stimulus involved in visual perception (GO:0050908)2.47784965
100startle response (GO:0001964)2.47682487
101epithelial cilium movement (GO:0003351)2.47505013
102regulation of meiosis I (GO:0060631)2.46737765
103cilium morphogenesis (GO:0060271)2.45996512
104regulation of cardioblast proliferation (GO:0003264)2.45481801
105regulation of secondary heart field cardioblast proliferation (GO:0003266)2.45481801
106protein localization to synapse (GO:0035418)2.44805494
107limb bud formation (GO:0060174)2.44643973
108protein polyglutamylation (GO:0018095)2.44573313
109dendritic spine morphogenesis (GO:0060997)2.43068633
110protein hydroxylation (GO:0018126)2.42663412
111extracellular matrix assembly (GO:0085029)2.42383615
112cellular response to sterol (GO:0036315)2.40999625
113membrane budding (GO:0006900)2.40759273
114regulation of axon guidance (GO:1902667)2.40663872
115dorsal/ventral axis specification (GO:0009950)2.39340068
116cytoplasmic mRNA processing body assembly (GO:0033962)2.39107653
117replication fork processing (GO:0031297)2.38898224
118C4-dicarboxylate transport (GO:0015740)2.38751038
119negative regulation of stem cell proliferation (GO:2000647)2.38546321
120cilium movement (GO:0003341)2.38396263
121maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.38396024
122auditory receptor cell stereocilium organization (GO:0060088)2.38384643
123endodermal cell differentiation (GO:0035987)2.38339546
124indolalkylamine metabolic process (GO:0006586)2.37891929
125nucleobase catabolic process (GO:0046113)2.37779399
126sister chromatid segregation (GO:0000819)2.36711512
127regulation of establishment or maintenance of cell polarity (GO:0032878)2.36344086
128dermatan sulfate biosynthetic process (GO:0030208)2.35783954
129negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.35682544
130negative regulation of translation, ncRNA-mediated (GO:0040033)2.35682544
131regulation of translation, ncRNA-mediated (GO:0045974)2.35682544
132nuclear pore organization (GO:0006999)2.35520528
133protein localization to cell surface (GO:0034394)2.35519743
134protein localization to cilium (GO:0061512)2.35424370
135cellular component assembly involved in morphogenesis (GO:0010927)2.35328676
136indole-containing compound catabolic process (GO:0042436)2.35235017
137indolalkylamine catabolic process (GO:0046218)2.35235017
138tryptophan catabolic process (GO:0006569)2.35235017
139embryonic cranial skeleton morphogenesis (GO:0048701)2.34489221
140nonmotile primary cilium assembly (GO:0035058)2.33842456
141negative regulation of axon extension involved in axon guidance (GO:0048843)2.33212777
142notochord development (GO:0030903)2.33065560
143regulation of DNA endoreduplication (GO:0032875)2.31997371
144retina layer formation (GO:0010842)2.31338236
145cranial suture morphogenesis (GO:0060363)2.30244230
146wound healing, spreading of epidermal cells (GO:0035313)2.29733995
147positive regulation of SMAD protein import into nucleus (GO:0060391)2.29270652
148plasma membrane repair (GO:0001778)2.27987737
149neuron recognition (GO:0008038)2.27981434
150monoubiquitinated protein deubiquitination (GO:0035520)2.27548091
151lipid translocation (GO:0034204)2.26903672
152phospholipid translocation (GO:0045332)2.26903672
153regulation of SMAD protein import into nucleus (GO:0060390)2.26885902
154protein targeting to lysosome (GO:0006622)2.26740645
155establishment of protein localization to vacuole (GO:0072666)2.26740645
156protein targeting to vacuole (GO:0006623)2.26740645
157regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.25075296
158negative chemotaxis (GO:0050919)2.24998176
159ventricular cardiac muscle cell development (GO:0055015)2.24673887
160G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.24462604
161nuclear pore complex assembly (GO:0051292)2.24387706
162regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.24060774
163sympathetic nervous system development (GO:0048485)2.23037400
164acrosome assembly (GO:0001675)2.22247477
165binding of sperm to zona pellucida (GO:0007339)2.21883570
166negative regulation of cartilage development (GO:0061037)2.21630974
167regulation of keratinocyte proliferation (GO:0010837)2.21411448
168planar cell polarity pathway involved in neural tube closure (GO:0090179)2.21059130
169embryonic digit morphogenesis (GO:0042733)2.20621144
170regulation of protein polyubiquitination (GO:1902914)2.19751939
171regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.19703597
172cardiac right ventricle morphogenesis (GO:0003215)2.19220705
173positive regulation of cardiac muscle cell differentiation (GO:2000727)2.17862924
174regulation of mitotic metaphase/anaphase transition (GO:0030071)2.16965474
175peptidyl-proline hydroxylation (GO:0019511)2.16763854
176ER overload response (GO:0006983)2.16663973
177cytoskeleton-dependent cytokinesis (GO:0061640)2.16511348
178negative regulation of embryonic development (GO:0045992)2.15789568
179regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.14214421
180G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.13646400
181regulation of mesenchymal cell proliferation (GO:0010464)2.13481002
182piRNA metabolic process (GO:0034587)2.13457398
183positive regulation of mesenchymal cell proliferation (GO:0002053)2.12660446
184regulation of mesoderm development (GO:2000380)2.12233694
185* substrate adhesion-dependent cell spreading (GO:0034446)2.12106843
186insulin-like growth factor receptor signaling pathway (GO:0048009)2.11991408
187regulation of mitotic spindle organization (GO:0060236)2.11129514
188regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.10866805
189extracellular fibril organization (GO:0043206)2.08475188
190regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.08472286
191response to X-ray (GO:0010165)2.08402145

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse5.09264275
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.39801939
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.07521381
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.87625531
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.74268974
6GBX2_23144817_ChIP-Seq_PC3_Human2.74234142
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.66819206
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.66269789
9TAF15_26573619_Chip-Seq_HEK293_Human2.60964034
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.48981297
11EZH2_22144423_ChIP-Seq_EOC_Human2.43520751
12CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.36966389
13HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.25475857
14WT1_19549856_ChIP-ChIP_CCG9911_Human2.23673151
15VDR_22108803_ChIP-Seq_LS180_Human2.16907405
16AR_21909140_ChIP-Seq_LNCAP_Human2.15396472
17CJUN_26792858_Chip-Seq_BT549_Human2.14565475
18KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.12982327
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08348465
20* BRD4_25478319_ChIP-Seq_HGPS_Human2.04121446
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.89077818
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.88618891
23TP53_16413492_ChIP-PET_HCT116_Human1.88480165
24EP300_21415370_ChIP-Seq_HL-1_Mouse1.88471550
25ZNF217_24962896_ChIP-Seq_MCF-7_Human1.86359709
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85737549
27* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.83571726
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.80913154
29NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.79374521
30NRF2_20460467_ChIP-Seq_MEFs_Mouse1.79374521
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.75646837
32FUS_26573619_Chip-Seq_HEK293_Human1.72815005
33PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.72071939
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71241733
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.68953257
36TCF4_18268006_ChIP-ChIP_LS174T_Human1.64210931
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.63243645
38CLOCK_20551151_ChIP-Seq_293T_Human1.61916515
39ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.60209693
40FOXM1_23109430_ChIP-Seq_U2OS_Human1.58786682
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58400344
42TP53_18474530_ChIP-ChIP_U2OS_Human1.56733920
43SALL4_18804426_ChIP-ChIP_XEN_Mouse1.55281829
44AR_21572438_ChIP-Seq_LNCaP_Human1.54257330
45SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.49511623
46ZNF274_21170338_ChIP-Seq_K562_Hela1.48470469
47SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48148934
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.47805956
49PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.47656805
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46351304
51* CBP_20019798_ChIP-Seq_JUKART_Human1.46332265
52* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46332265
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43593672
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42577024
55OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40561435
56SMAD4_21799915_ChIP-Seq_A2780_Human1.40368604
57EWS_26573619_Chip-Seq_HEK293_Human1.38254039
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37528367
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.37094628
60E2F7_22180533_ChIP-Seq_HELA_Human1.36704747
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34151766
62RUNX2_22187159_ChIP-Seq_PCA_Human1.33438012
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33434152
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31032271
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31032271
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27046157
67NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.25209467
68FLI1_21867929_ChIP-Seq_TH2_Mouse1.24911884
69KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24822374
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24761453
71MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.24600265
72STAT3_23295773_ChIP-Seq_U87_Human1.24162721
73SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.22992463
74SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.22992463
75CBX2_27304074_Chip-Seq_ESCs_Mouse1.22844161
76E2F1_18555785_Chip-Seq_ESCs_Mouse1.21981603
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21582302
78RNF2_27304074_Chip-Seq_NSC_Mouse1.21345072
79* SOX2_21211035_ChIP-Seq_LN229_Gbm1.20946879
80CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.20515150
81TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.20441626
82SMAD4_21741376_ChIP-Seq_EPCs_Human1.19624433
83CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.18950317
84TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18948377
85P53_22387025_ChIP-Seq_ESCs_Mouse1.18836963
86CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18555083
87AR_25329375_ChIP-Seq_VCAP_Human1.17331563
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16954458
89IGF1R_20145208_ChIP-Seq_DFB_Human1.16018339
90SOX9_26525672_Chip-Seq_HEART_Mouse1.15864917
91KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14865575
92NFE2_27457419_Chip-Seq_LIVER_Mouse1.14459208
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14254938
94RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14086177
95KDM2B_26808549_Chip-Seq_REH_Human1.13602774
96P300_19829295_ChIP-Seq_ESCs_Human1.12950989
97ARNT_22903824_ChIP-Seq_MCF-7_Human1.10407058
98TAL1_26923725_Chip-Seq_HPCs_Mouse1.10021832
99TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.09544813
100CMYC_18555785_Chip-Seq_ESCs_Mouse1.09389266
101TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09368369
102ELK4_26923725_Chip-Seq_MESODERM_Mouse1.09109511
103CDX2_22108803_ChIP-Seq_LS180_Human1.08870716
104CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08816459
105SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.08315910
106BCAT_22108803_ChIP-Seq_LS180_Human1.08269946
107* PRDM14_20953172_ChIP-Seq_ESCs_Human1.08139565
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07784261
109CRX_20693478_ChIP-Seq_RETINA_Mouse1.07404776
110SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06941644
111RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06878307
112TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05989294
113HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05473835
114TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03562478
115PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02974192
116ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01969988
117ER_23166858_ChIP-Seq_MCF-7_Human1.01954661
118SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.01703160
119TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01496111
120ELK1_19687146_ChIP-ChIP_HELA_Human1.00878140
121PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00526863
122CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00001049
123EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.99966929
124* TCF4_23295773_ChIP-Seq_U87_Human0.99872802
125* TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.99593526
126FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.99262480
127ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98214419
128TCF4_22108803_ChIP-Seq_LS180_Human0.97749100
129NANOG_18555785_Chip-Seq_ESCs_Mouse0.97669127
130UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97350685
131ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97116480
132SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.96441609
133GF1B_26923725_Chip-Seq_HPCs_Mouse0.96304899
134SMAD3_21741376_ChIP-Seq_EPCs_Human0.96060953
135GATA1_26923725_Chip-Seq_HPCs_Mouse0.95984383
136ISL1_27105846_Chip-Seq_CPCs_Mouse0.95803481
137AHR_22903824_ChIP-Seq_MCF-7_Human0.95800406
138* JUN_21703547_ChIP-Seq_K562_Human0.94057794
139FOXM1_26456572_ChIP-Seq_MCF-7_Human0.93934966
140EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93781652
141RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.93640775

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.94329674
2MP0005503_abnormal_tendon_morphology4.27637640
3MP0005275_abnormal_skin_tensile3.85235769
4MP0003705_abnormal_hypodermis_morpholog2.96176286
5MP0003279_aneurysm2.79421083
6MP0010030_abnormal_orbit_morphology2.67941930
7MP0004272_abnormal_basement_membrane2.51878372
8MP0000569_abnormal_digit_pigmentation2.27676122
9MP0005171_absent_coat_pigmentation2.21172866
10MP0010352_gastrointestinal_tract_polyps2.04594928
11MP0008057_abnormal_DNA_replication2.04279093
12MP0002735_abnormal_chemical_nociception2.00247576
13MP0009384_cardiac_valve_regurgitation1.99329371
14MP0003880_abnormal_central_pattern1.98919765
15MP0003566_abnormal_cell_adhesion1.93016115
16MP0005551_abnormal_eye_electrophysiolog1.89192520
17MP0003136_yellow_coat_color1.88578370
18MP0000778_abnormal_nervous_system1.88421501
19MP0009046_muscle_twitch1.85104731
20MP0001958_emphysema1.83877150
21MP0009697_abnormal_copulation1.83416988
22MP0002102_abnormal_ear_morphology1.83083902
23MP0005257_abnormal_intraocular_pressure1.75099794
24MP0005508_abnormal_skeleton_morphology1.74378437
25MP0001299_abnormal_eye_distance/1.72655232
26MP0006054_spinal_hemorrhage1.71263933
27MP0006276_abnormal_autonomic_nervous1.69469889
28MP0002060_abnormal_skin_morphology1.67300361
29MP0006072_abnormal_retinal_apoptosis1.67088299
30MP0005623_abnormal_meninges_morphology1.65721559
31MP0005253_abnormal_eye_physiology1.64523469
32MP0000383_abnormal_hair_follicle1.61985525
33MP0002736_abnormal_nociception_after1.61035851
34MP0001968_abnormal_touch/_nociception1.58268878
35MP0003941_abnormal_skin_development1.56982153
36MP0000516_abnormal_urinary_system1.54356627
37MP0005367_renal/urinary_system_phenotyp1.54356627
38MP0004885_abnormal_endolymph1.52838364
39MP0003195_calcinosis1.52555664
40MP0010368_abnormal_lymphatic_system1.50595891
41MP0009053_abnormal_anal_canal1.50239449
42MP0005187_abnormal_penis_morphology1.49618430
43MP0009780_abnormal_chondrocyte_physiolo1.48740084
44MP0001486_abnormal_startle_reflex1.48655340
45MP0003121_genomic_imprinting1.48563934
46MP0003385_abnormal_body_wall1.47410618
47MP0009250_abnormal_appendicular_skeleto1.46397386
48MP0000647_abnormal_sebaceous_gland1.46358906
49MP0008007_abnormal_cellular_replicative1.44712200
50MP0004270_analgesia1.41205859
51MP0005174_abnormal_tail_pigmentation1.37681745
52MP0002272_abnormal_nervous_system1.36987832
53MP0002928_abnormal_bile_duct1.35747649
54MP0003937_abnormal_limbs/digits/tail_de1.34909225
55MP0002108_abnormal_muscle_morphology1.34839706
56MP0003123_paternal_imprinting1.33235862
57MP0001529_abnormal_vocalization1.30844314
58MP0003122_maternal_imprinting1.30292575
59MP0003755_abnormal_palate_morphology1.30248798
60MP0002282_abnormal_trachea_morphology1.27895729
61MP0009745_abnormal_behavioral_response1.26745833
62MP0004043_abnormal_pH_regulation1.26392918
63MP0010678_abnormal_skin_adnexa1.24604829
64MP0002734_abnormal_mechanical_nocicepti1.23766903
65MP0003787_abnormal_imprinting1.23261184
66MP0000372_irregular_coat_pigmentation1.21130856
67MP0010307_abnormal_tumor_latency1.20505356
68MP0000427_abnormal_hair_cycle1.19997518
69MP0001485_abnormal_pinna_reflex1.19115352
70MP0003635_abnormal_synaptic_transmissio1.18673764
71MP0005386_behavior/neurological_phenoty1.18031333
72MP0004924_abnormal_behavior1.18031333
73MP0002572_abnormal_emotion/affect_behav1.17528907
74MP0002557_abnormal_social/conspecific_i1.16553704
75MP0002896_abnormal_bone_mineralization1.14898487
76MP0005023_abnormal_wound_healing1.13447388
77MP0002877_abnormal_melanocyte_morpholog1.12094116
78MP0003942_abnormal_urinary_system1.11993428
79MP0000428_abnormal_craniofacial_morphol1.11972886
80MP0002177_abnormal_outer_ear1.11559005
81MP0000537_abnormal_urethra_morphology1.11054357
82MP0002184_abnormal_innervation1.10850301
83MP0004859_abnormal_synaptic_plasticity1.10151972
84MP0003718_maternal_effect1.09934389
85MP0000631_abnormal_neuroendocrine_gland1.09356142
86MP0002067_abnormal_sensory_capabilities1.09118448
87MP0005423_abnormal_somatic_nervous1.08047483
88MP0005670_abnormal_white_adipose1.07044133
89MP0000534_abnormal_ureter_morphology1.05794825
90MP0004233_abnormal_muscle_weight1.05597059
91MP0010234_abnormal_vibrissa_follicle1.02336714
92MP0001243_abnormal_dermal_layer1.02330395
93MP0001501_abnormal_sleep_pattern1.01897151
94MP0004145_abnormal_muscle_electrophysio1.01572223
95MP0005248_abnormal_Harderian_gland1.01411274
96MP0002638_abnormal_pupillary_reflex1.00428050
97MP0003115_abnormal_respiratory_system0.99936240
98MP0000013_abnormal_adipose_tissue0.99846223
99MP0002063_abnormal_learning/memory/cond0.99678011
100MP0008789_abnormal_olfactory_epithelium0.98673593
101MP0003091_abnormal_cell_migration0.98188511
102MP0004084_abnormal_cardiac_muscle0.97635203
103MP0000432_abnormal_head_morphology0.97252685
104MP0002837_dystrophic_cardiac_calcinosis0.97221083
105MP0005408_hypopigmentation0.96161937
106MP0005646_abnormal_pituitary_gland0.95479170
107MP0002233_abnormal_nose_morphology0.94956406
108MP0005195_abnormal_posterior_eye0.94952902
109MP0000767_abnormal_smooth_muscle0.94820011
110MP0001970_abnormal_pain_threshold0.94391769
111MP0004133_heterotaxia0.94057390
112MP0003935_abnormal_craniofacial_develop0.93600907
113MP0001915_intracranial_hemorrhage0.92600983
114MP0002295_abnormal_pulmonary_circulatio0.92425876
115MP0008877_abnormal_DNA_methylation0.92395269
116MP0000955_abnormal_spinal_cord0.92001603
117MP0004142_abnormal_muscle_tone0.91533278
118MP0002882_abnormal_neuron_morphology0.91372091
119MP0005645_abnormal_hypothalamus_physiol0.91247623
120MP0002095_abnormal_skin_pigmentation0.91088610
121MP0005391_vision/eye_phenotype0.90357513
122MP0002752_abnormal_somatic_nervous0.90226801
123MP0002115_abnormal_skeleton_extremities0.89395340
124MP0002938_white_spotting0.88830274
125MP0005197_abnormal_uvea_morphology0.88685561
126MP0003183_abnormal_peptide_metabolism0.88649655
127MP0002751_abnormal_autonomic_nervous0.88312230
128MP0000049_abnormal_middle_ear0.88257242
129MP0002160_abnormal_reproductive_system0.87169546
130MP0002116_abnormal_craniofacial_bone0.86949219
131MP0001542_abnormal_bone_strength0.85449322
132MP0001984_abnormal_olfaction0.85003435
133MP0008775_abnormal_heart_ventricle0.84555380
134MP0003119_abnormal_digestive_system0.84261212
135MP0003633_abnormal_nervous_system0.83649477
136MP0001293_anophthalmia0.83602367
137MP0000733_abnormal_muscle_development0.83545548
138MP0002109_abnormal_limb_morphology0.83446177
139MP0000163_abnormal_cartilage_morphology0.82504824
140MP0002733_abnormal_thermal_nociception0.80879260
141MP0005395_other_phenotype0.80279262
142MP0002234_abnormal_pharynx_morphology0.80149762
143MP0000749_muscle_degeneration0.80109812
144MP0001879_abnormal_lymphatic_vessel0.79973463
145MP0004197_abnormal_fetal_growth/weight/0.79938576
146MP0003950_abnormal_plasma_membrane0.79879762
147MP0003943_abnormal_hepatobiliary_system0.79846834
148MP0006138_congestive_heart_failure0.79108503
149MP0002111_abnormal_tail_morphology0.79084712
150MP0002064_seizures0.77484817
151MP0002925_abnormal_cardiovascular_devel0.77412159
152MP0003252_abnormal_bile_duct0.77302397
153MP0002168_other_aberrant_phenotype0.74698068
154MP0005390_skeleton_phenotype0.73678038
155MP0000750_abnormal_muscle_regeneration0.73534558
156MP0004215_abnormal_myocardial_fiber0.73191203
157MP0005076_abnormal_cell_differentiation0.72989917
158MP0003890_abnormal_embryonic-extraembry0.72347821
159MP0005220_abnormal_exocrine_pancreas0.71614917
160MP0002697_abnormal_eye_size0.71515546
161MP0001177_atelectasis0.71440640
162MP0010386_abnormal_urinary_bladder0.70816646
163MP0002972_abnormal_cardiac_muscle0.70196130
164MP0002084_abnormal_developmental_patter0.66573113
165MP0000762_abnormal_tongue_morphology0.65820068

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.14885661
2Protrusio acetabuli (HP:0003179)4.47064290
3Hyperventilation (HP:0002883)3.86410456
4Soft skin (HP:0000977)3.84872594
5Shallow orbits (HP:0000586)3.62789538
6Pancreatic cysts (HP:0001737)3.62577814
7Pancreatic fibrosis (HP:0100732)3.58613460
8Aortic aneurysm (HP:0004942)3.44532458
9Chronic hepatic failure (HP:0100626)3.41206023
10Aplasia/Hypoplasia of the tibia (HP:0005772)3.41191228
11True hermaphroditism (HP:0010459)3.40187426
12Abnormality of dentin (HP:0010299)3.36410892
13Fair hair (HP:0002286)3.23195554
14Nephronophthisis (HP:0000090)3.17760835
15Abnormality of midbrain morphology (HP:0002418)3.12639835
16Molar tooth sign on MRI (HP:0002419)3.12639835
17Ankle contracture (HP:0006466)3.09359313
18Abnormality of the renal medulla (HP:0100957)3.07092456
19Genetic anticipation (HP:0003743)3.03907628
20Wrist flexion contracture (HP:0001239)3.02639687
21Atrophic scars (HP:0001075)2.98638269
22Vascular tortuosity (HP:0004948)2.96363430
23Bladder diverticulum (HP:0000015)2.95309211
24Aortic dissection (HP:0002647)2.94341181
25Gaze-evoked nystagmus (HP:0000640)2.92028164
26Papillary thyroid carcinoma (HP:0002895)2.79932028
27Medial flaring of the eyebrow (HP:0010747)2.76705244
28Progressive cerebellar ataxia (HP:0002073)2.75472837
29Abnormality of the renal cortex (HP:0011035)2.73362327
30Volvulus (HP:0002580)2.71861217
31Genital tract atresia (HP:0001827)2.68729641
32Short nail (HP:0001799)2.68724716
33Wormian bones (HP:0002645)2.61923329
34Drooling (HP:0002307)2.61568867
35Microglossia (HP:0000171)2.60795743
36Dilatation of the ascending aorta (HP:0005111)2.60353636
37Gait imbalance (HP:0002141)2.57870309
38Broad metatarsal (HP:0001783)2.56643941
39Absent speech (HP:0001344)2.56542518
40Follicular hyperkeratosis (HP:0007502)2.56003444
41Bell-shaped thorax (HP:0001591)2.54770356
42Focal seizures (HP:0007359)2.48200405
43Spinal rigidity (HP:0003306)2.47741990
44Congenital primary aphakia (HP:0007707)2.47596785
45Vaginal atresia (HP:0000148)2.44645984
46Cervical subluxation (HP:0003308)2.44294028
47Protruding tongue (HP:0010808)2.43909737
48Febrile seizures (HP:0002373)2.43144262
49Arterial tortuosity (HP:0005116)2.41019099
50Increased connective tissue (HP:0009025)2.38180087
51Bowel diverticulosis (HP:0005222)2.37866272
52Nephrogenic diabetes insipidus (HP:0009806)2.36636101
53Genu recurvatum (HP:0002816)2.36223107
54Broad-based gait (HP:0002136)2.35228039
55Hemiparesis (HP:0001269)2.33547201
56Generalized hypopigmentation of hair (HP:0011358)2.33418005
57Cerebellar dysplasia (HP:0007033)2.33360515
58Cerebral aneurysm (HP:0004944)2.32952874
59Short tibia (HP:0005736)2.30563212
60Fragile skin (HP:0001030)2.28725714
61Excessive salivation (HP:0003781)2.24944308
62Cystic liver disease (HP:0006706)2.24235184
63Neoplasm of the adrenal cortex (HP:0100641)2.23104619
64Increased corneal curvature (HP:0100692)2.20201203
65Keratoconus (HP:0000563)2.20201203
66Asymmetry of the thorax (HP:0001555)2.20002405
67Focal motor seizures (HP:0011153)2.19824871
68Abnormality of the labia minora (HP:0012880)2.18918383
69Tubular atrophy (HP:0000092)2.18885490
70Congenital sensorineural hearing impairment (HP:0008527)2.17808860
71Overgrowth (HP:0001548)2.16664680
72Attenuation of retinal blood vessels (HP:0007843)2.16211297
73Postaxial foot polydactyly (HP:0001830)2.14881414
74Bifid tongue (HP:0010297)2.11172003
75Tubulointerstitial nephritis (HP:0001970)2.10406414
76Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.08831204
77Short 4th metacarpal (HP:0010044)2.08831204
78Congenital hepatic fibrosis (HP:0002612)2.08331530
79Tubulointerstitial abnormality (HP:0001969)2.08256799
80Widely spaced teeth (HP:0000687)2.04763633
81Lissencephaly (HP:0001339)2.04492090
82Short foot (HP:0001773)2.03800468
83Chorioretinal atrophy (HP:0000533)2.02444997
84Aplasia involving bones of the extremities (HP:0009825)2.02288773
85Aplasia involving bones of the upper limbs (HP:0009823)2.02288773
86Aplasia of the phalanges of the hand (HP:0009802)2.02288773
87Hyperextensible skin (HP:0000974)2.00918760
88Joint laxity (HP:0001388)1.99996936
89Preaxial foot polydactyly (HP:0001841)1.99548874
90Bony spicule pigmentary retinopathy (HP:0007737)1.99259016
91Abnormality of the ischium (HP:0003174)1.99238338
92Blue sclerae (HP:0000592)1.98987991
93Fibular aplasia (HP:0002990)1.98701974
94Mesomelia (HP:0003027)1.98471949
95Dialeptic seizures (HP:0011146)1.98145126
96Biconcave vertebral bodies (HP:0004586)1.97781105
97Poor coordination (HP:0002370)1.97079261
98Renal cortical cysts (HP:0000803)1.96103683
99Postaxial hand polydactyly (HP:0001162)1.95510062
100Type 1 muscle fiber predominance (HP:0003803)1.94374070
101Intestinal atresia (HP:0011100)1.92823041
102Broad long bones (HP:0005622)1.91154130
103Adrenal hypoplasia (HP:0000835)1.90896584
104Tarsal synostosis (HP:0008368)1.90709096
105Small hand (HP:0200055)1.90054577
106Glioma (HP:0009733)1.89775421
107Furrowed tongue (HP:0000221)1.89717119
108Occipital encephalocele (HP:0002085)1.89503590
109Slender build (HP:0001533)1.85827801
110Atonic seizures (HP:0010819)1.85505630
111Aneurysm (HP:0002617)1.84054673
112Cortical dysplasia (HP:0002539)1.81907772
113Synostosis involving bones of the lower limbs (HP:0009138)1.81634167
114Synostosis involving bones of the feet (HP:0009140)1.81634167
115Abnormality of the phalanges of the hallux (HP:0010057)1.81550962
116Exotropia (HP:0000577)1.80530304
117Sclerocornea (HP:0000647)1.77887971
118Thyroid carcinoma (HP:0002890)1.77296308
119Spinal muscular atrophy (HP:0007269)1.76920307
120Abnormality of the astrocytes (HP:0100707)1.76074490
121Astrocytoma (HP:0009592)1.76074490
122Aplasia/Hypoplasia of the fibula (HP:0006492)1.74477907
123Broad ribs (HP:0000885)1.74367747
124Renal hypoplasia (HP:0000089)1.74080623
125Enlarged penis (HP:0000040)1.73827343
126Highly arched eyebrow (HP:0002553)1.73640579
127Pachygyria (HP:0001302)1.73242703
128Type II lissencephaly (HP:0007260)1.72999766
129Mildly elevated creatine phosphokinase (HP:0008180)1.72887245
130Astigmatism (HP:0000483)1.72614222
131Tubulointerstitial fibrosis (HP:0005576)1.72440646
132Aplasia/Hypoplasia of the tongue (HP:0010295)1.71879557
133Aplasia/Hypoplasia of the lens (HP:0008063)1.71612866
134Hypoplastic labia majora (HP:0000059)1.71012676
135Supernumerary spleens (HP:0009799)1.70771544
136Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.70651179
137Natal tooth (HP:0000695)1.70209945
138Coronal craniosynostosis (HP:0004440)1.69845816
139Polydipsia (HP:0001959)1.69019774
140Abnormal drinking behavior (HP:0030082)1.69019774
141Abnormality of the 4th metacarpal (HP:0010012)1.68561659
142Progressive inability to walk (HP:0002505)1.68362708
143Elbow flexion contracture (HP:0002987)1.66599787
144Submucous cleft hard palate (HP:0000176)1.66441933
145Blue irides (HP:0000635)1.66056487
146Preaxial hand polydactyly (HP:0001177)1.65273204
147Absence seizures (HP:0002121)1.65090470
148Hypoplastic ischia (HP:0003175)1.64864377
149Narrow forehead (HP:0000341)1.63988340
150Vertebral compression fractures (HP:0002953)1.63926006
151Broad foot (HP:0001769)1.63692771
152Neonatal short-limb short stature (HP:0008921)1.63254328
153Anencephaly (HP:0002323)1.62551380
154Knee flexion contracture (HP:0006380)1.62544123
155Limb-girdle muscle weakness (HP:0003325)1.61838352
156Morphological abnormality of the middle ear (HP:0008609)1.61560073
157Broad phalanx (HP:0006009)1.60913281
158Scapular winging (HP:0003691)1.59353074
159Dynein arm defect of respiratory motile cilia (HP:0012255)1.59159553
160Absent/shortened dynein arms (HP:0200106)1.59159553
161Cupped ear (HP:0000378)1.59129297
162Subacute progressive viral hepatitis (HP:0006572)1.58262951
163Congenital stationary night blindness (HP:0007642)1.58226356
164Spinal cord lesions (HP:0100561)1.57835621
165Syringomyelia (HP:0003396)1.57835621
166Aqueductal stenosis (HP:0002410)1.57394927
167Prominent nasal bridge (HP:0000426)1.56883010
168Abnormality of the labia (HP:0000058)1.56742267
169Abnormal auditory evoked potentials (HP:0006958)1.55985607
170Micropenis (HP:0000054)1.55698462
171Abolished electroretinogram (ERG) (HP:0000550)1.55585316
172Hyperglycemia (HP:0003074)1.55391306
173Fibular hypoplasia (HP:0003038)1.55034789
174Breast carcinoma (HP:0003002)1.53290803
175Mitral valve prolapse (HP:0001634)1.53215737
176Abnormality of the labia majora (HP:0012881)1.53191854
177Hepatoblastoma (HP:0002884)1.52169468
178Delayed closure of the anterior fontanelle (HP:0001476)1.51451582
179Hypoplasia of the maxilla (HP:0000327)1.50887059
180Buphthalmos (HP:0000557)1.50536818
181Urethral obstruction (HP:0000796)1.50000373
182Cutaneous finger syndactyly (HP:0010554)1.49663556
183Camptodactyly of toe (HP:0001836)1.49294651
184Right ventricular cardiomyopathy (HP:0011663)1.49088664
185Hematochezia (HP:0002573)1.47170375
186Broad finger (HP:0001500)1.46073185
187Deep philtrum (HP:0002002)1.45968889
188Short hallux (HP:0010109)1.45623597
189Cutaneous syndactyly (HP:0012725)1.43382907
190Abnormality of the distal phalanx of the thumb (HP:0009617)1.42051223
191Deviation of the hallux (HP:0010051)1.41001667
192Shoulder girdle muscle weakness (HP:0003547)1.40981353

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.15795874
2PDK23.67398342
3AKT33.22149011
4CCNB13.11372615
5ERBB33.06183068
6LATS12.74049212
7PRKD32.39439473
8ZAK2.38816154
9WNK32.37500606
10STK38L2.32667624
11SIK32.32142022
12MARK12.27708107
13TNIK2.15901928
14ACVR1B2.10474593
15LATS22.04859297
16CASK1.94631354
17BCR1.93577560
18TRIM281.93537300
19PNCK1.92784269
20DDR21.85018360
21STK391.84661726
22PDK31.80165198
23PDK41.80165198
24TTN1.76122032
25STK31.74893843
26NUAK11.62278149
27PLK31.53317842
28FGFR21.53033648
29MET1.52756197
30MAP4K21.49344179
31PLK21.44398874
32NEK11.44072788
33MKNK21.43293319
34NTRK31.39145716
35TESK11.38813701
36PDGFRA1.38559394
37PINK11.37649890
38KSR11.35719599
39LIMK11.31853475
40WNK41.27766170
41TRPM71.26589895
42MAP2K71.25196171
43* FER1.23236813
44OXSR11.23211602
45PIK3CA1.17764239
46ERBB41.16560148
47NEK61.13539589
48ADRBK21.09691710
49SGK21.06918063
50ROCK11.04464288
51CSNK1G21.02868112
52PTK2B1.02608872
53YES11.01460188
54CSNK1A1L1.01365387
55GRK10.99436479
56PAK30.98521043
57CSNK1G10.97534525
58CAMK1G0.97156234
59NEK90.96620436
60TTK0.92653759
61EPHA40.92044776
62CDC70.91213449
63BMPR1B0.90377499
64BRAF0.88929857
65EIF2AK30.88676692
66EPHB20.83380594
67ADRBK10.82912088
68CAMK1D0.82379012
69NEK20.81514854
70DMPK0.79283826
71CAMKK20.78269315
72BRSK20.73191840
73SIK10.72863704
74MAP3K40.72810079
75TRIB30.71499981
76PLK10.69578758
77SCYL20.69081778
78MKNK10.68933291
79DYRK20.67373862
80CHEK20.67164882
81MST40.66345838
82RPS6KA40.66322724
83CSNK1G30.66196049
84AURKA0.65595921
85MUSK0.64678445
86CAMK2A0.64140888
87TSSK60.63695528
88PKN10.62755875
89SGK4940.62655894
90SGK2230.62655894
91SGK30.61779217
92WNK10.60769690
93BRD40.59349683
94RIPK10.57619784
95MAPK130.57386377
96AURKB0.55566062
97PTK20.55267089
98CDK60.55159066
99NTRK20.55153862
100MAP2K10.54552148
101STK240.54484695
102FLT30.54138973
103PAK20.53443265
104NLK0.53409515
105PRKCG0.53254843
106ILK0.52963179
107MINK10.51782099
108EPHA20.51761723
109FGFR10.51100411
110MAPK70.51026438
111EPHA30.49317671
112PIK3CG0.49126113
113ATM0.48883260
114PRKCE0.47687663
115CDK30.47022395
116IRAK10.46782826
117ATR0.44658278
118CAMK40.44357535
119EIF2AK20.43917085
120CDC42BPA0.43823234
121OBSCN0.43812421
122PKN20.43708547
123PBK0.43052038
124STK380.42518346
125SRPK10.42074169
126PHKG20.40948715
127PHKG10.40948715
128MELK0.40785428
129CSNK1D0.40193837
130BMPR20.40108667
131TGFBR20.39608150
132MTOR0.39043563
133ERBB20.38446308
134INSRR0.38198008
135PLK40.36610646
136TIE10.36260246
137PRKACB0.35940306
138PDGFRB0.35932543
139CAMK10.35629343
140PRKG10.35211179
141MAP3K70.34423335
142PRKAA10.32998807
143CDK50.32777552
144CAMK2B0.32759817
145CAMK2D0.30761684
146PRKACA0.30613342
147CDK80.29299831
148TGFBR10.27263804
149IGF1R0.26433858
150FGFR30.25610244
151WEE10.25176582
152CDK10.24719762
153AKT10.22467701

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.71756246
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.67589366
3ECM-receptor interaction_Homo sapiens_hsa045122.30950372
4Butanoate metabolism_Homo sapiens_hsa006502.21936994
5Phototransduction_Homo sapiens_hsa047442.16416435
6* Adherens junction_Homo sapiens_hsa045202.15221344
7Cell cycle_Homo sapiens_hsa041102.13018188
8Focal adhesion_Homo sapiens_hsa045102.10855310
9Hippo signaling pathway_Homo sapiens_hsa043902.06259261
10Ubiquitin mediated proteolysis_Homo sapiens_hsa041202.05487180
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.04111223
12Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.99539143
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.87849016
14Glutamatergic synapse_Homo sapiens_hsa047241.82409350
15TGF-beta signaling pathway_Homo sapiens_hsa043501.80844696
16Dilated cardiomyopathy_Homo sapiens_hsa054141.79583057
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.79478800
18Taste transduction_Homo sapiens_hsa047421.76025345
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.73359146
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.71739123
21Propanoate metabolism_Homo sapiens_hsa006401.68216914
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.66935295
23Circadian entrainment_Homo sapiens_hsa047131.64687818
24Dorso-ventral axis formation_Homo sapiens_hsa043201.64522820
25MicroRNAs in cancer_Homo sapiens_hsa052061.62505835
26Proteoglycans in cancer_Homo sapiens_hsa052051.59307869
27Small cell lung cancer_Homo sapiens_hsa052221.56913651
28GABAergic synapse_Homo sapiens_hsa047271.56585652
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.56191973
30Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.55629330
31Melanoma_Homo sapiens_hsa052181.51612860
32ABC transporters_Homo sapiens_hsa020101.50911344
33Morphine addiction_Homo sapiens_hsa050321.50856829
34Tight junction_Homo sapiens_hsa045301.48598015
35Ether lipid metabolism_Homo sapiens_hsa005651.48447540
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45687287
37p53 signaling pathway_Homo sapiens_hsa041151.43335777
38Oocyte meiosis_Homo sapiens_hsa041141.43171103
39Endometrial cancer_Homo sapiens_hsa052131.42456329
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.39742599
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.39294720
42Circadian rhythm_Homo sapiens_hsa047101.37864620
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.37369462
44One carbon pool by folate_Homo sapiens_hsa006701.36839198
45Nitrogen metabolism_Homo sapiens_hsa009101.35382403
46Prostate cancer_Homo sapiens_hsa052151.33431666
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.32811089
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.32283837
49PI3K-Akt signaling pathway_Homo sapiens_hsa041511.31202837
50Bladder cancer_Homo sapiens_hsa052191.28003930
51Basal cell carcinoma_Homo sapiens_hsa052171.26656817
52Linoleic acid metabolism_Homo sapiens_hsa005911.25283879
53Salivary secretion_Homo sapiens_hsa049701.23439207
54RNA transport_Homo sapiens_hsa030131.23206182
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22390410
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.22336520
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.20940739
58Phagosome_Homo sapiens_hsa041451.19325237
59Serotonergic synapse_Homo sapiens_hsa047261.18524459
60N-Glycan biosynthesis_Homo sapiens_hsa005101.16860530
61Fanconi anemia pathway_Homo sapiens_hsa034601.16493604
62Hedgehog signaling pathway_Homo sapiens_hsa043401.15384820
63Maturity onset diabetes of the young_Homo sapiens_hsa049501.14522698
64Long-term depression_Homo sapiens_hsa047301.14192406
65Insulin secretion_Homo sapiens_hsa049111.13817107
66Steroid biosynthesis_Homo sapiens_hsa001001.12602177
67Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.11732002
68Steroid hormone biosynthesis_Homo sapiens_hsa001401.11640175
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.10519593
70Calcium signaling pathway_Homo sapiens_hsa040201.10220791
71Systemic lupus erythematosus_Homo sapiens_hsa053221.09707168
72Non-homologous end-joining_Homo sapiens_hsa034501.09127215
73Basal transcription factors_Homo sapiens_hsa030221.08875771
74Tryptophan metabolism_Homo sapiens_hsa003801.08175722
75Glioma_Homo sapiens_hsa052141.07004928
76Fatty acid biosynthesis_Homo sapiens_hsa000611.06848565
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.06757531
78Vibrio cholerae infection_Homo sapiens_hsa051101.05670206
79Glucagon signaling pathway_Homo sapiens_hsa049221.04281444
80Alcoholism_Homo sapiens_hsa050341.02645119
81Protein export_Homo sapiens_hsa030601.01074083
82Colorectal cancer_Homo sapiens_hsa052101.00611483
83Amoebiasis_Homo sapiens_hsa051460.97109212
84Pancreatic cancer_Homo sapiens_hsa052120.96411753
85Mismatch repair_Homo sapiens_hsa034300.95499972
86Nucleotide excision repair_Homo sapiens_hsa034200.92662923
87Axon guidance_Homo sapiens_hsa043600.92428572
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91840387
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.90022407
90Pathways in cancer_Homo sapiens_hsa052000.88445386
91Wnt signaling pathway_Homo sapiens_hsa043100.88344958
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.86804447
93Histidine metabolism_Homo sapiens_hsa003400.86147362
94cAMP signaling pathway_Homo sapiens_hsa040240.85937664
95Protein digestion and absorption_Homo sapiens_hsa049740.85878961
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85522001
97Rap1 signaling pathway_Homo sapiens_hsa040150.82637627
98Viral carcinogenesis_Homo sapiens_hsa052030.82352271
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.81019760
100Cocaine addiction_Homo sapiens_hsa050300.81011698
101Cholinergic synapse_Homo sapiens_hsa047250.79961802
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78903856
103mTOR signaling pathway_Homo sapiens_hsa041500.75764349
104Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74105482
105ErbB signaling pathway_Homo sapiens_hsa040120.72597006
106Gastric acid secretion_Homo sapiens_hsa049710.71820251
107Renal cell carcinoma_Homo sapiens_hsa052110.71122612
108mRNA surveillance pathway_Homo sapiens_hsa030150.70781889
109Oxytocin signaling pathway_Homo sapiens_hsa049210.70664033
110HIF-1 signaling pathway_Homo sapiens_hsa040660.69896633
111Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69722513
112RNA degradation_Homo sapiens_hsa030180.69317016
113Glycerolipid metabolism_Homo sapiens_hsa005610.68827453
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68373189
115Ras signaling pathway_Homo sapiens_hsa040140.68246238
116Selenocompound metabolism_Homo sapiens_hsa004500.67969512
117Amphetamine addiction_Homo sapiens_hsa050310.67559572
118Fatty acid metabolism_Homo sapiens_hsa012120.67475450
119Malaria_Homo sapiens_hsa051440.64030043
120Arachidonic acid metabolism_Homo sapiens_hsa005900.63600103
121Chronic myeloid leukemia_Homo sapiens_hsa052200.63415346
122FoxO signaling pathway_Homo sapiens_hsa040680.63088965
123Endocytosis_Homo sapiens_hsa041440.62834984
124SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62643521
125Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62150427
126Sulfur metabolism_Homo sapiens_hsa009200.62052041
127HTLV-I infection_Homo sapiens_hsa051660.61717265
128Insulin signaling pathway_Homo sapiens_hsa049100.61449156
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60792734
130Renin-angiotensin system_Homo sapiens_hsa046140.59634570
131Sphingolipid metabolism_Homo sapiens_hsa006000.58968646
132Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58938862
133Retinol metabolism_Homo sapiens_hsa008300.58772696
134cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58702785
135Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58408611
136Melanogenesis_Homo sapiens_hsa049160.57837211
137Caffeine metabolism_Homo sapiens_hsa002320.57186728
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56477749
139Insulin resistance_Homo sapiens_hsa049310.55852582
140Regulation of autophagy_Homo sapiens_hsa041400.54738468
141Vascular smooth muscle contraction_Homo sapiens_hsa042700.54366221
142Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53359692
143Pancreatic secretion_Homo sapiens_hsa049720.53321619
144AMPK signaling pathway_Homo sapiens_hsa041520.53198159
145Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.52634813
146Hepatitis B_Homo sapiens_hsa051610.52338840
147Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52044182
148Gap junction_Homo sapiens_hsa045400.51986059
149Ovarian steroidogenesis_Homo sapiens_hsa049130.50310033
150Estrogen signaling pathway_Homo sapiens_hsa049150.49745502
151Chemical carcinogenesis_Homo sapiens_hsa052040.49101239
152Renin secretion_Homo sapiens_hsa049240.49014570
153AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47090169
154beta-Alanine metabolism_Homo sapiens_hsa004100.43252282
155Thyroid hormone synthesis_Homo sapiens_hsa049180.42206800
156Dopaminergic synapse_Homo sapiens_hsa047280.38438128
157Olfactory transduction_Homo sapiens_hsa047400.37433994
158Lysine degradation_Homo sapiens_hsa003100.36818504
159Homologous recombination_Homo sapiens_hsa034400.36728748

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