FER1L4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1digestion (GO:0007586)8.03338973
2regulation of proton transport (GO:0010155)7.47428633
3protein autoprocessing (GO:0016540)7.35366658
4regulation of phospholipase A2 activity (GO:0032429)7.33268648
5extracellular fibril organization (GO:0043206)7.01607439
6one-carbon compound transport (GO:0019755)6.80740267
7O-glycan processing (GO:0016266)6.62007196
8digestive system process (GO:0022600)6.21296677
9bundle of His cell to Purkinje myocyte communication (GO:0086069)6.14266721
10fibril organization (GO:0097435)6.02999792
11glutathione derivative biosynthetic process (GO:1901687)5.94414934
12glutathione derivative metabolic process (GO:1901685)5.94414934
13hypotonic response (GO:0006971)5.58819214
14sulfation (GO:0051923)5.53317804
15phosphatidylserine acyl-chain remodeling (GO:0036150)5.45742798
16phosphatidylinositol acyl-chain remodeling (GO:0036149)4.68061434
17hemidesmosome assembly (GO:0031581)4.65241092
18protein O-linked glycosylation (GO:0006493)4.60339081
19lung epithelium development (GO:0060428)4.52730724
20phosphatidylserine metabolic process (GO:0006658)4.49533902
213-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.41691866
22purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.41691866
23phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.28349824
24nephron epithelium morphogenesis (GO:0072088)4.27522303
25nephron tubule morphogenesis (GO:0072078)4.27522303
26L-fucose catabolic process (GO:0042355)4.25166233
27fucose catabolic process (GO:0019317)4.25166233
28L-fucose metabolic process (GO:0042354)4.25166233
29thyroid hormone metabolic process (GO:0042403)4.25033764
30regulation of pH (GO:0006885)4.24008246
31arachidonic acid secretion (GO:0050482)4.14120849
32icosanoid secretion (GO:0032309)4.14120849
33antibacterial humoral response (GO:0019731)4.10262643
34neutrophil mediated immunity (GO:0002446)4.08955720
35leukotriene biosynthetic process (GO:0019370)4.04214442
36phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.03723537
37pH reduction (GO:0045851)4.02593655
38potassium ion homeostasis (GO:0055075)4.01509018
39response to iron ion (GO:0010039)4.01083051
40thyroid hormone generation (GO:0006590)4.01030144
41flavonoid metabolic process (GO:0009812)3.94681588
42fatty acid derivative transport (GO:1901571)3.91016224
43icosanoid transport (GO:0071715)3.91016224
44antimicrobial humoral response (GO:0019730)3.90990309
45citrulline biosynthetic process (GO:0019240)3.87505959
46leukotriene metabolic process (GO:0006691)3.82611921
47behavioral response to nicotine (GO:0035095)3.82216455
48ventricular cardiac muscle cell action potential (GO:0086005)3.81551285
49growth hormone secretion (GO:0030252)3.79143030
50intestinal epithelial cell development (GO:0060576)3.69182276
51glandular epithelial cell differentiation (GO:0002067)3.67790058
52acrosome reaction (GO:0007340)3.64076209
53lung vasculature development (GO:0060426)3.64059420
54innate immune response in mucosa (GO:0002227)3.63507944
55regulation of ruffle assembly (GO:1900027)3.63219767
56monovalent inorganic cation homeostasis (GO:0055067)3.60199190
57alditol phosphate metabolic process (GO:0052646)3.58863243
58kidney morphogenesis (GO:0060993)3.58165102
59protein retention in ER lumen (GO:0006621)3.57652243
60desmosome organization (GO:0002934)3.56807970
61negative regulation of digestive system process (GO:0060457)3.52858644
62cobalamin metabolic process (GO:0009235)3.50163425
63intestinal absorption (GO:0050892)3.47745600
64peptidyl-proline hydroxylation (GO:0019511)3.43198536
65maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.36010358
66epithelial cell-cell adhesion (GO:0090136)3.34822130
67lung lobe morphogenesis (GO:0060463)3.32450510
68diacylglycerol metabolic process (GO:0046339)3.32119288
69vitamin transport (GO:0051180)3.29945586
70positive regulation of histone deacetylation (GO:0031065)3.29792288
71striated muscle atrophy (GO:0014891)3.29163190
72myeloid leukocyte mediated immunity (GO:0002444)3.29045014
73epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.28782886
74embryonic foregut morphogenesis (GO:0048617)3.28061367
75positive regulation of triglyceride biosynthetic process (GO:0010867)3.26269033
76positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.25772541
77sodium ion homeostasis (GO:0055078)3.25004348
78phospholipid scrambling (GO:0017121)3.24031283
79galactose catabolic process (GO:0019388)3.23152512
80regulation of skeletal muscle contraction (GO:0014819)3.14898996
81production of molecular mediator of immune response (GO:0002440)3.13249598
82negative regulation of axon extension involved in axon guidance (GO:0048843)3.12884885
83diol metabolic process (GO:0034311)3.12435353
84semaphorin-plexin signaling pathway (GO:0071526)3.06452760
85extracellular matrix assembly (GO:0085029)3.05887865
86L-serine transport (GO:0015825)3.05310909
87atrioventricular valve morphogenesis (GO:0003181)3.01747105
88sphingosine metabolic process (GO:0006670)3.00865538
89cytoskeletal anchoring at plasma membrane (GO:0007016)2.98890458
90mucosal immune response (GO:0002385)2.97013446
91cardiac right ventricle morphogenesis (GO:0003215)2.96371116
92sodium ion export (GO:0071436)2.95918811
93regulation of heart rate by cardiac conduction (GO:0086091)2.94155346
94positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.93842386
95negative regulation of T cell differentiation in thymus (GO:0033085)2.92815133
96phosphatidylcholine acyl-chain remodeling (GO:0036151)2.90239395
97regulation of hippo signaling (GO:0035330)2.88260103
98positive regulation of CREB transcription factor activity (GO:0032793)2.87697502
99regulation of cardioblast differentiation (GO:0051890)2.86491654
100glutathione metabolic process (GO:0006749)2.85945618
101renal tubule morphogenesis (GO:0061333)2.85411568
102sulfur amino acid catabolic process (GO:0000098)2.83187590
103positive regulation of fatty acid oxidation (GO:0046321)2.82372432
104establishment of monopolar cell polarity (GO:0061162)2.82129613
105establishment or maintenance of monopolar cell polarity (GO:0061339)2.82129613
106skeletal muscle adaptation (GO:0043501)2.80260230
107acid secretion (GO:0046717)2.79540265
108negative regulation of axon guidance (GO:1902668)2.77994549
109epithelial cilium movement (GO:0003351)2.77609113
110organ or tissue specific immune response (GO:0002251)2.77421602
111response to nitrosative stress (GO:0051409)2.77357564
112positive regulation of protein kinase C signaling (GO:0090037)2.76375717
113sulfate transmembrane transport (GO:1902358)2.75683956
114regulation of axon extension involved in axon guidance (GO:0048841)2.75106393
115fucosylation (GO:0036065)2.74595320
116central nervous system myelination (GO:0022010)2.73118216
117axon ensheathment in central nervous system (GO:0032291)2.73118216
118regulation of cholesterol biosynthetic process (GO:0045540)2.73107082
119protein hydroxylation (GO:0018126)2.73068046
120negative regulation of kidney development (GO:0090185)2.71942351
121xenobiotic metabolic process (GO:0006805)2.71715396
122basic amino acid transport (GO:0015802)2.71470416
123endocardial cushion development (GO:0003197)2.70889208
124cyclooxygenase pathway (GO:0019371)2.70278224
125epithelial cell differentiation involved in prostate gland development (GO:0060742)2.69703658
126positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.69534758
127inner ear receptor cell differentiation (GO:0060113)2.68566087
128estrogen biosynthetic process (GO:0006703)2.68085081
129nitric oxide biosynthetic process (GO:0006809)2.66859911
130positive regulation of gastrulation (GO:2000543)2.66731620
131fucose metabolic process (GO:0006004)2.66580309
132auditory receptor cell differentiation (GO:0042491)2.66016369
133mesonephros development (GO:0001823)2.65389316
134positive regulation of fatty acid beta-oxidation (GO:0032000)2.65213540
135citrulline metabolic process (GO:0000052)2.63414185
136interferon-gamma secretion (GO:0072643)2.63296011
137serine transport (GO:0032329)2.62740302
138cardiac conduction (GO:0061337)2.62355606
139muscle atrophy (GO:0014889)2.61123612
140phosphatidic acid biosynthetic process (GO:0006654)2.60726579
141sulfate transport (GO:0008272)2.60605579
142regulation of triglyceride biosynthetic process (GO:0010866)2.58263165
143myelin maintenance (GO:0043217)2.58196295
144startle response (GO:0001964)2.58184674
145rRNA catabolic process (GO:0016075)2.57684112
146regulation of axon guidance (GO:1902667)2.56974822
147neuronal ion channel clustering (GO:0045161)2.55442655
148cellular glucuronidation (GO:0052695)2.54326379
149alkaloid metabolic process (GO:0009820)2.54142079
150ear development (GO:0043583)2.50891713
151establishment of apical/basal cell polarity (GO:0035089)2.49272129
152axoneme assembly (GO:0035082)2.48719528
153regulation of hydrogen peroxide metabolic process (GO:0010310)2.48415380
154glucuronate metabolic process (GO:0019585)2.47870449
155uronic acid metabolic process (GO:0006063)2.47870449
156response to food (GO:0032094)2.46819712
157ectoderm development (GO:0007398)2.45602057
158branching involved in salivary gland morphogenesis (GO:0060445)2.45386514
159auditory receptor cell stereocilium organization (GO:0060088)2.44487305
160parturition (GO:0007567)2.44326569
161pattern specification involved in kidney development (GO:0061004)2.44254565
162multicellular organism reproduction (GO:0032504)2.43523459
163response to pheromone (GO:0019236)2.43298585
164glycerophospholipid catabolic process (GO:0046475)2.43265568
165facial nerve structural organization (GO:0021612)2.41578442
166endothelial cell chemotaxis (GO:0035767)2.40209748
167collecting duct development (GO:0072044)2.39201797
168cellular ketone body metabolic process (GO:0046950)2.38750350
169cilium movement (GO:0003341)2.38719521
170positive regulation of sodium ion transmembrane transport (GO:1902307)2.38166928
171glutathione biosynthetic process (GO:0006750)2.37953100
172vitamin transmembrane transport (GO:0035461)2.37789529
173detection of light stimulus involved in visual perception (GO:0050908)2.37146734
174detection of light stimulus involved in sensory perception (GO:0050962)2.37146734
175regulation of microtubule-based movement (GO:0060632)2.36671235
176trivalent inorganic anion homeostasis (GO:0072506)2.36555377
177phosphate ion homeostasis (GO:0055062)2.36555377
178xenobiotic catabolic process (GO:0042178)2.35743671
179opioid receptor signaling pathway (GO:0038003)2.35454255
180negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.32003545
181white fat cell differentiation (GO:0050872)2.31684538
182regulation of mitochondrial fission (GO:0090140)2.31160317
183maintenance of gastrointestinal epithelium (GO:0030277)13.6018909
184epithelial structure maintenance (GO:0010669)10.7009175

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.58842601
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.46239421
3ESR1_15608294_ChIP-ChIP_MCF-7_Human4.45010114
4SOX2_27498859_Chip-Seq_STOMACH_Mouse4.38438635
5STAT6_21828071_ChIP-Seq_BEAS2B_Human4.12362208
6ESR1_21235772_ChIP-Seq_MCF-7_Human3.74090638
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.37760082
8ESR2_21235772_ChIP-Seq_MCF-7_Human3.31546782
9RARG_19884340_ChIP-ChIP_MEFs_Mouse3.06863487
10ZNF274_21170338_ChIP-Seq_K562_Hela2.68316660
11* GATA4_25053715_ChIP-Seq_YYC3_Human2.57343145
12CDX2_20551321_ChIP-Seq_CACO-2_Human2.52808265
13TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.51605498
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.37888490
15* SOX2_20726797_ChIP-Seq_SW620_Human2.27766912
16* PPAR_26484153_Chip-Seq_NCI-H1993_Human2.26135503
17HIF1A_21447827_ChIP-Seq_MCF-7_Human2.20678897
18ESR1_20079471_ChIP-ChIP_T-47D_Human2.19334102
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.12772080
20GATA6_25053715_ChIP-Seq_YYC3_Human2.08912294
21ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.01779661
22TRIM28_21343339_ChIP-Seq_HEK293_Human2.00589794
23KLF5_25053715_ChIP-Seq_YYC3_Human2.00575029
24RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95751589
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.84330406
26AHR_22903824_ChIP-Seq_MCF-7_Human1.75785960
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.74963224
28EGR1_19032775_ChIP-ChIP_M12_Human1.73544447
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70803198
30SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.70496787
31SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.70496787
32CTCF_27219007_Chip-Seq_Bcells_Human1.68802270
33RACK7_27058665_Chip-Seq_MCF-7_Human1.68573866
34EZH2_27294783_Chip-Seq_ESCs_Mouse1.66197879
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.65067037
36KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.63556003
37DROSHA_22980978_ChIP-Seq_HELA_Human1.63217985
38TDRD3_21172665_ChIP-Seq_MCF-7_Human1.60946161
39VDR_22108803_ChIP-Seq_LS180_Human1.60147648
40ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.60000962
41P63_26484246_Chip-Seq_KERATINOCYTES_Human1.58233774
42ERA_21632823_ChIP-Seq_H3396_Human1.57452662
43LXR_22292898_ChIP-Seq_THP-1_Human1.57082841
44RUNX1_27514584_Chip-Seq_MCF-7_Human1.56327424
45STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.52563072
46FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.51734429
47FOXO3_23340844_ChIP-Seq_DLD1_Human1.50989287
48KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.50717644
49SUZ12_27294783_Chip-Seq_ESCs_Mouse1.47916757
50GATA3_24758297_ChIP-Seq_MCF-7_Human1.47025754
51P68_20966046_ChIP-Seq_HELA_Human1.46814462
52RARB_24833708_ChIP-Seq_LIVER_Mouse1.45825921
53PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.45554844
54ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.44215287
55E2F1_20622854_ChIP-Seq_HELA_Human1.42529131
56PPARA_22158963_ChIP-Seq_LIVER_Mouse1.42435207
57CLOCK_20551151_ChIP-Seq_293T_Human1.41677832
58SRY_22984422_ChIP-ChIP_TESTIS_Rat1.41600683
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40934276
60EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.39638190
61* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.38285314
62ZNF263_19887448_ChIP-Seq_K562_Human1.37536070
63KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.36818849
64KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.36818849
65KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.36818849
66* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.35348648
67TP53_22127205_ChIP-Seq_IMR90_Human1.34783855
68CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.34493445
69JARID2_20075857_ChIP-Seq_MESCs_Mouse1.30770671
70FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.30243809
71CTCF_20526341_ChIP-Seq_ESCs_Human1.29896545
72RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.29685875
73EP300_21415370_ChIP-Seq_HL-1_Mouse1.29683098
74AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.28662804
75LXR_22158963_ChIP-Seq_LIVER_Mouse1.26554707
76JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24372224
77SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.23629001
78PHF8_20622854_ChIP-Seq_HELA_Human1.23325452
79TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20200522
80SMC4_20622854_ChIP-Seq_HELA_Human1.19650710
81EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19525160
82RXR_22158963_ChIP-Seq_LIVER_Mouse1.19471685
83HOXB7_26014856_ChIP-Seq_BT474_Human1.19153722
84TCF4_18268006_ChIP-ChIP_LS174T_Human1.19077324
85P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.18896602
86SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18053831
87NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.16431070
88IGF1R_20145208_ChIP-Seq_DFB_Human1.16297694
89TAF2_19829295_ChIP-Seq_ESCs_Human1.16146445
90CJUN_26792858_Chip-Seq_BT549_Human1.14345426
91* BCL6_27268052_Chip-Seq_Bcells_Human1.13172094
92RAC3_21632823_ChIP-Seq_H3396_Human1.11683800
93BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11556135
94JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11277966
95NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.11157135
96ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09739050
97P53_21459846_ChIP-Seq_SAOS-2_Human1.09418123
98ARNT_22903824_ChIP-Seq_MCF-7_Human1.09396591
99ER_23166858_ChIP-Seq_MCF-7_Human1.09288959
100SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.08460513
101ATF3_27146783_Chip-Seq_COLON_Human1.07795644
102YY1_22570637_ChIP-Seq_MALME-3M_Human1.05940158
103EED_16625203_ChIP-ChIP_MESCs_Mouse1.05537977
104CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05038195
105* BCOR_27268052_Chip-Seq_Bcells_Human1.04682668
106IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04516083
107* MYC_19829295_ChIP-Seq_ESCs_Human1.04316107
108TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.04195067
109RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02849584
110BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.02797885
111GATA2_21666600_ChIP-Seq_HMVEC_Human1.02382629
112ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01474437
113FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01053108
114FOXA1_25329375_ChIP-Seq_VCAP_Human1.01053108
115PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.00407677
116CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99874332
117RNF2_27304074_Chip-Seq_ESCs_Mouse0.99739614
118* FOXH1_21741376_ChIP-Seq_ESCs_Human0.99056836
119HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98774984
120SA1_27219007_Chip-Seq_Bcells_Human0.98631004
121STAT1_20625510_ChIP-Seq_HELA_Human0.98330399
122OCT4_20526341_ChIP-Seq_ESCs_Human0.97567243
123FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97165065
124GATA3_21878914_ChIP-Seq_MCF-7_Human0.96640168
125NANOG_20526341_ChIP-Seq_ESCs_Human0.96513624
126ELK4_26923725_Chip-Seq_MESODERM_Mouse0.95961193
127FOXA2_19822575_ChIP-Seq_HepG2_Human0.94911246
128TP63_22573176_ChIP-Seq_HFKS_Human0.94297992
129TP53_20018659_ChIP-ChIP_R1E_Mouse0.94089886
130UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.92801293
131RAD21_21589869_ChIP-Seq_MESCs_Mouse0.92114411
132SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91735602
133EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.91421879
134REST_21632747_ChIP-Seq_MESCs_Mouse0.90373870
135TET1_21451524_ChIP-Seq_MESCs_Mouse0.90371549
136NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.90270662
137MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.89739352
138SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.89523318
139ERG_21242973_ChIP-ChIP_JURKAT_Human0.89427264
140FOXP1_21924763_ChIP-Seq_HESCs_Human0.88559910
141RXR_22108803_ChIP-Seq_LS180_Human0.86043845
142NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.85097881
143POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.84844292
144EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.84750366
145* KDM2B_26808549_Chip-Seq_K562_Human0.84532498
146NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.83964905
147ELK3_25401928_ChIP-Seq_HUVEC_Human0.82993759
148BCAT_22108803_ChIP-Seq_LS180_Human0.82562187
149CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.82318814
150DNAJC2_21179169_ChIP-ChIP_NT2_Human0.80510583
151* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80212859
152NRF2_20460467_ChIP-Seq_MEFs_Mouse0.79426244
153NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.79426244
154HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.77975518
155GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.77684946
156TBX20_22080862_ChIP-Seq_HEART_Mouse0.77445407
157TBX20_22328084_ChIP-Seq_HEART_Mouse0.77445407
158SALL4_18804426_ChIP-ChIP_XEN_Mouse0.77282335
159CREB1_26743006_Chip-Seq_LNCaP_Human0.76151625
160SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75243102

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001664_abnormal_digestion5.14447108
2MP0000516_abnormal_urinary_system4.67998507
3MP0005367_renal/urinary_system_phenotyp4.67998507
4MP0001873_stomach_inflammation4.04976932
5MP0010386_abnormal_urinary_bladder3.86951761
6MP0000470_abnormal_stomach_morphology3.63799359
7MP0010234_abnormal_vibrissa_follicle2.79430494
8MP0001666_abnormal_nutrient_absorption2.62875500
9MP0003136_yellow_coat_color2.34611656
10MP0004133_heterotaxia2.17472611
11MP0003122_maternal_imprinting2.17022720
12MP0006054_spinal_hemorrhage2.04433089
13MP0005377_hearing/vestibular/ear_phenot2.04154663
14MP0003878_abnormal_ear_physiology2.04154663
15MP0003806_abnormal_nucleotide_metabolis2.02975278
16MP0009780_abnormal_chondrocyte_physiolo2.00890955
17MP0008004_abnormal_stomach_pH14.6265222
18MP0001502_abnormal_circadian_rhythm1.88005586
19MP0010030_abnormal_orbit_morphology1.81047479
20MP0001663_abnormal_digestive_system1.78506838
21MP0005645_abnormal_hypothalamus_physiol1.76435570
22MP0005381_digestive/alimentary_phenotyp1.76131819
23MP0008872_abnormal_physiological_respon1.75393175
24MP0000462_abnormal_digestive_system1.74139762
25MP0002653_abnormal_ependyma_morphology1.70765499
26MP0004264_abnormal_extraembryonic_tissu1.70380332
27MP0005360_urolithiasis1.68819891
28MP0000534_abnormal_ureter_morphology1.64622882
29MP0003123_paternal_imprinting1.63245347
30MP0004043_abnormal_pH_regulation1.59308204
31MP0000537_abnormal_urethra_morphology1.53720299
32MP0005165_increased_susceptibility_to1.50473943
33MP0005551_abnormal_eye_electrophysiolog1.47817001
34MP0005083_abnormal_biliary_tract1.45213908
35MP0001756_abnormal_urination1.45127352
36MP0002876_abnormal_thyroid_physiology1.44633585
37MP0001968_abnormal_touch/_nociception1.38476373
38MP0002138_abnormal_hepatobiliary_system1.36906853
39MP0008775_abnormal_heart_ventricle1.35942510
40MP0002102_abnormal_ear_morphology1.34821145
41MP0000427_abnormal_hair_cycle1.34114081
42MP0008789_abnormal_olfactory_epithelium1.27505238
43MP0000477_abnormal_intestine_morphology1.26733190
44MP0002938_white_spotting1.25347270
45MP0002249_abnormal_larynx_morphology1.21934263
46MP0001485_abnormal_pinna_reflex1.19037484
47MP0003283_abnormal_digestive_organ1.18989640
48MP0003705_abnormal_hypodermis_morpholog1.18716116
49MP0003942_abnormal_urinary_system1.15347537
50MP0006276_abnormal_autonomic_nervous1.13122077
51MP0002796_impaired_skin_barrier1.12441294
52MP0002184_abnormal_innervation1.12101454
53MP0005275_abnormal_skin_tensile1.07492407
54MP0000026_abnormal_inner_ear1.07014495
55MP0002735_abnormal_chemical_nociception1.05595961
56MP0003868_abnormal_feces_composition1.03141355
57MP0001348_abnormal_lacrimal_gland1.03075919
58MP0003566_abnormal_cell_adhesion1.02996244
59MP0003121_genomic_imprinting1.02196048
60MP0002733_abnormal_thermal_nociception1.00771616
61MP0002089_abnormal_postnatal_growth/wei0.99143653
62MP0001905_abnormal_dopamine_level0.98987957
63MP0003866_abnormal_defecation0.98618866
64MP0005085_abnormal_gallbladder_physiolo0.94774532
65MP0004782_abnormal_surfactant_physiolog0.93668680
66MP0005499_abnormal_olfactory_system0.91627093
67MP0005394_taste/olfaction_phenotype0.91627093
68MP0001970_abnormal_pain_threshold0.91486544
69MP0004185_abnormal_adipocyte_glucose0.90308119
70MP0008875_abnormal_xenobiotic_pharmacok0.89184811
71MP0001986_abnormal_taste_sensitivity0.88295361
72MP0002932_abnormal_joint_morphology0.88224841
73MP0000647_abnormal_sebaceous_gland0.88041231
74MP0001984_abnormal_olfaction0.87653783
75MP0005670_abnormal_white_adipose0.87304845
76MP0003119_abnormal_digestive_system0.86985806
77MP0010155_abnormal_intestine_physiology0.86363366
78MP0001958_emphysema0.86292065
79MP0002282_abnormal_trachea_morphology0.85914873
80MP0002060_abnormal_skin_morphology0.84878106
81MP0000538_abnormal_urinary_bladder0.84844392
82MP0006292_abnormal_olfactory_placode0.84825609
83MP0002557_abnormal_social/conspecific_i0.84628303
84MP0003937_abnormal_limbs/digits/tail_de0.84319554
85MP0010678_abnormal_skin_adnexa0.83475478
86MP0002752_abnormal_somatic_nervous0.82546538
87MP0003879_abnormal_hair_cell0.82431432
88MP0003938_abnormal_ear_development0.80670804
89MP0009384_cardiac_valve_regurgitation0.80167460
90MP0002736_abnormal_nociception_after0.79712662
91MP0001944_abnormal_pancreas_morphology0.79102350
92MP0002254_reproductive_system_inflammat0.78715795
93MP0000631_abnormal_neuroendocrine_gland0.77272025
94MP0005195_abnormal_posterior_eye0.76919337
95MP0005646_abnormal_pituitary_gland0.76869397
96MP0000467_abnormal_esophagus_morphology0.76802197
97MP0003936_abnormal_reproductive_system0.76480713
98MP0002909_abnormal_adrenal_gland0.75822169
99MP0002234_abnormal_pharynx_morphology0.75518804
100MP0003115_abnormal_respiratory_system0.74690348
101MP0002163_abnormal_gland_morphology0.73127031
102MP0008438_abnormal_cutaneous_collagen0.72913065
103MP0000613_abnormal_salivary_gland0.71675962
104MP0002116_abnormal_craniofacial_bone0.71070028
105MP0002160_abnormal_reproductive_system0.70931044
106MP0010352_gastrointestinal_tract_polyps0.70865397
107MP0003755_abnormal_palate_morphology0.70848771
108MP0004381_abnormal_hair_follicle0.70837898
109MP0000049_abnormal_middle_ear0.70777573
110MP0000490_abnormal_crypts_of0.70538471
111MP0002638_abnormal_pupillary_reflex0.69202814
112MP0003453_abnormal_keratinocyte_physiol0.68085011
113MP0001963_abnormal_hearing_physiology0.67606398
114MP0004484_altered_response_of0.67154041
115MP0001501_abnormal_sleep_pattern0.66704153
116MP0002928_abnormal_bile_duct0.66230456
117MP0000372_irregular_coat_pigmentation0.66219515
118MP0005501_abnormal_skin_physiology0.65937676
119MP0005166_decreased_susceptibility_to0.64830053
120MP0004019_abnormal_vitamin_homeostasis0.64159697
121MP0009643_abnormal_urine_homeostasis0.62375715
122MP0001216_abnormal_epidermal_layer0.62313811
123MP0004272_abnormal_basement_membrane0.60975450
124MP0001849_ear_inflammation0.60958308
125MP0000013_abnormal_adipose_tissue0.59265897
126MP0010329_abnormal_lipoprotein_level0.58197653
127MP0000465_gastrointestinal_hemorrhage0.56153337
128MP0005365_abnormal_bile_salt0.53825442
129MP0004947_skin_inflammation0.53094795
130MP0004858_abnormal_nervous_system0.51433513
131MP0003186_abnormal_redox_activity0.51250237
132MP0003252_abnormal_bile_duct0.50697283
133MP0009053_abnormal_anal_canal0.50519533
134MP0010771_integument_phenotype0.47928140
135MP0002136_abnormal_kidney_physiology0.46908547
136MP0003075_altered_response_to0.44898972
137MP0001765_abnormal_ion_homeostasis0.43252041
138MP0005636_abnormal_mineral_homeostasis0.42206874
139MP0002098_abnormal_vibrissa_morphology0.41729002
140MP0005266_abnormal_metabolism0.41313583
141MP0001243_abnormal_dermal_layer0.40873238
142MP0004036_abnormal_muscle_relaxation0.40298252
143MP0005620_abnormal_muscle_contractility0.38489106
144MP0002837_dystrophic_cardiac_calcinosis0.35879443
145MP0000230_abnormal_systemic_arterial0.35562549
146MP0003315_abnormal_perineum_morphology0.34366536
147MP0005319_abnormal_enzyme/_coenzyme0.33073538
148MP0000566_synostosis0.32847789
149MP0003300_gastrointestinal_ulcer0.31825331
150MP0000762_abnormal_tongue_morphology0.31711167
151MP0000383_abnormal_hair_follicle0.31704592
152MP0000627_abnormal_mammary_gland0.31057754
153MP0002118_abnormal_lipid_homeostasis0.29711679
154MP0005023_abnormal_wound_healing0.29426579
155MP0003953_abnormal_hormone_level0.29285944
156MP0000377_abnormal_hair_follicle0.28660229
157MP0000579_abnormal_nail_morphology0.28364727
158MP0009931_abnormal_skin_appearance0.28093746
159MP0009642_abnormal_blood_homeostasis0.26483803
160MP0005330_cardiomyopathy0.26389882
161MP0005623_abnormal_meninges_morphology0.25857283
162MP0000367_abnormal_coat/_hair0.25415204
163MP0004084_abnormal_cardiac_muscle0.24037252
164MP0003045_fibrosis0.24032011
165MP0005666_abnormal_adipose_tissue0.23795761
166MP0005464_abnormal_platelet_physiology0.22938220
167MP0003941_abnormal_skin_development0.22715556
168MP0005164_abnormal_response_to0.22047243
169MP0000343_altered_response_to0.21759659
170MP0005332_abnormal_amino_acid0.21640577
171MP0002970_abnormal_white_adipose0.20770183

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)8.49717850
2Abnormality of cells of the erythroid lineage (HP:0012130)7.62283940
3Aortic aneurysm (HP:0004942)7.60662963
4Right ventricular cardiomyopathy (HP:0011663)7.18187333
5Aortic dissection (HP:0002647)6.59838959
6Malnutrition (HP:0004395)5.20848481
7Gastrointestinal dysmotility (HP:0002579)5.18126429
8Neoplasm of the heart (HP:0100544)4.93152699
9Tubular atrophy (HP:0000092)4.24535275
10Megaloblastic anemia (HP:0001889)4.20148191
11Abnormality of the vitamin B12 metabolism (HP:0004341)4.07935496
12Abnormality of abdominal situs (HP:0011620)3.79187291
13Abdominal situs inversus (HP:0003363)3.79187291
14Abnormality of vitamin B metabolism (HP:0004340)3.78030822
15Ankle contracture (HP:0006466)3.75967360
16Cystic liver disease (HP:0006706)3.68376328
17Congenital stationary night blindness (HP:0007642)3.62546702
18Cerebral aneurysm (HP:0004944)3.59341980
19Nephronophthisis (HP:0000090)3.53627230
20Onycholysis (HP:0001806)3.47532529
21Atrophic scars (HP:0001075)3.37902613
22Abnormality of the renal medulla (HP:0100957)3.29682167
23Pancreatic cysts (HP:0001737)3.26184600
24Abnormality of vitamin metabolism (HP:0100508)3.20643728
25Pendular nystagmus (HP:0012043)3.18784926
26Molar tooth sign on MRI (HP:0002419)3.17850153
27Abnormality of midbrain morphology (HP:0002418)3.17850153
28Aortic regurgitation (HP:0001659)3.17634970
29True hermaphroditism (HP:0010459)3.13146022
30Type II lissencephaly (HP:0007260)3.05438430
31Milia (HP:0001056)2.99408717
32Aneurysm (HP:0002617)2.99384074
33Goiter (HP:0000853)2.97024672
34Amelogenesis imperfecta (HP:0000705)2.94643406
35Pancreatic fibrosis (HP:0100732)2.94236787
36Hydroureter (HP:0000072)2.91328607
37Hyperparathyroidism (HP:0000843)2.89754565
38Ulnar bowing (HP:0003031)2.87884987
39Focal segmental glomerulosclerosis (HP:0000097)2.86946930
40Ventricular fibrillation (HP:0001663)2.84551234
41Abnormality of the renal cortex (HP:0011035)2.83802361
42Stridor (HP:0010307)2.77991689
43Ureteral stenosis (HP:0000071)2.75793626
44Gout (HP:0001997)2.74076592
45Scapular winging (HP:0003691)2.72333978
46Dilatation of the ascending aorta (HP:0005111)2.71774651
47Concave nail (HP:0001598)2.71053858
48Palpitations (HP:0001962)2.69934230
49Fragile nails (HP:0001808)2.69501355
50Woolly hair (HP:0002224)2.66952733
51Short hallux (HP:0010109)2.62254554
52Syncope (HP:0001279)2.61343223
53Abnormal foot bone ossification (HP:0010675)2.60737504
54Abnormality of the 2nd finger (HP:0004100)2.60425085
55Chronic hepatic failure (HP:0100626)2.60271172
56J-shaped sella turcica (HP:0002680)2.56195951
57Stage 5 chronic kidney disease (HP:0003774)2.51929985
58Cerebellar dysplasia (HP:0007033)2.51917936
59Ureteral obstruction (HP:0006000)2.50417550
60Facial diplegia (HP:0001349)2.50084940
61Conical tooth (HP:0000698)2.47252734
62Abnormal pupillary function (HP:0007686)2.46552026
63Severe muscular hypotonia (HP:0006829)2.45870173
64Occipital encephalocele (HP:0002085)2.44335221
65Pigmentary retinal degeneration (HP:0001146)2.38593917
66Spastic diplegia (HP:0001264)2.37939667
67Radial bowing (HP:0002986)2.36047476
68Attenuation of retinal blood vessels (HP:0007843)2.35894265
69Increased density of long bones (HP:0006392)2.35834879
70Osteolytic defects of the hand bones (HP:0009699)2.35686212
71Osteolytic defects of the phalanges of the hand (HP:0009771)2.35686212
72Abnormal rod and cone electroretinograms (HP:0008323)2.35560644
73Pili torti (HP:0003777)2.34723447
74Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)2.33709172
75Bicuspid aortic valve (HP:0001647)2.33063851
76Ventricular tachycardia (HP:0004756)2.32519304
77Arterial tortuosity (HP:0005116)2.32507223
78Aplasia/Hypoplasia of the hallux (HP:0008362)2.32445571
79Long foot (HP:0001833)2.30502076
80Abnormality of the vitreous humor (HP:0004327)2.29754417
81Abnormality of oral frenula (HP:0000190)2.28179293
82Clumsiness (HP:0002312)2.26018273
83Abnormal ossification of hand bones (HP:0005921)2.25445101
84Fragile skin (HP:0001030)2.25162559
85Curly hair (HP:0002212)2.25077352
86Abnormality of proline metabolism (HP:0010907)2.23704531
87Hydroxyprolinuria (HP:0003080)2.23704531
88Long toe (HP:0010511)2.23007508
89Decreased circulating renin level (HP:0003351)2.20807797
90Thin bony cortex (HP:0002753)2.19146400
91Sclerocornea (HP:0000647)2.18370844
92Abnormal drinking behavior (HP:0030082)2.17946848
93Polydipsia (HP:0001959)2.17946848
94Type 1 muscle fiber predominance (HP:0003803)2.17241444
95Bony spicule pigmentary retinopathy (HP:0007737)2.17214805
96Vascular tortuosity (HP:0004948)2.14822243
97Renal salt wasting (HP:0000127)2.13574603
98Broad distal phalanx of finger (HP:0009836)2.12512566
99Wrist flexion contracture (HP:0001239)2.11813548
100Shawl scrotum (HP:0000049)2.10927517
101Absent frontal sinuses (HP:0002688)2.08404124
102Abnormality of renal excretion (HP:0011036)2.08130516
103Anophthalmia (HP:0000528)2.07678590
104Stroke (HP:0001297)2.06714533
105Abnormality of the distal phalanx of the thumb (HP:0009617)2.06578024
106Facial shape deformation (HP:0011334)2.06491245
107Potter facies (HP:0002009)2.06491245
108Plantar hyperkeratosis (HP:0007556)2.04733286
109Mesomelia (HP:0003027)2.04043172
110Tibial bowing (HP:0002982)2.02757873
111Elbow flexion contracture (HP:0002987)2.02675180
112Rib fusion (HP:0000902)2.02082855
113Broad face (HP:0000283)2.00114304
114Broad metatarsal (HP:0001783)1.99527684
115Distal upper limb amyotrophy (HP:0007149)1.98639581
116Upper limb amyotrophy (HP:0009129)1.98639581
117Hyperactive renin-angiotensin system (HP:0000841)1.97996370
118Hyperkalemia (HP:0002153)1.97930771
119Abnormal biliary tract physiology (HP:0012439)1.97452268
120Bile duct proliferation (HP:0001408)1.97452268
121Medial flaring of the eyebrow (HP:0010747)1.96334875
122Ventricular arrhythmia (HP:0004308)1.95984380
123Bowing of the arm (HP:0006488)1.95622042
124Bowed forearm bones (HP:0003956)1.95622042
125Flat acetabular roof (HP:0003180)1.94695558
126Frequent falls (HP:0002359)1.94513763
127Increased connective tissue (HP:0009025)1.94100186
128Testicular atrophy (HP:0000029)1.93933768
129Abnormality of permanent molar morphology (HP:0011071)1.92419995
130Abnormality of the dental root (HP:0006486)1.92419995
131Taurodontia (HP:0000679)1.92419995
132Oligodontia (HP:0000677)1.92209966
133Tubulointerstitial fibrosis (HP:0005576)1.91732528
134Glomerulosclerosis (HP:0000096)1.90925139
135Cerebral palsy (HP:0100021)1.90813386
136Abnormality of the nasal septum (HP:0000419)1.90066500
137Bronchomalacia (HP:0002780)1.87587844
138Back pain (HP:0003418)1.87584033
139Septate vagina (HP:0001153)1.87011106
140Persistence of primary teeth (HP:0006335)1.86733159
141Hypoplasia of the pons (HP:0012110)1.86616092
142Abdominal distention (HP:0003270)1.86272878
143Micronodular cirrhosis (HP:0001413)1.86122960
144Polyuria (HP:0000103)1.85991934
145Abnormality of the calcaneus (HP:0008364)1.85467387
146Aplasia involving bones of the upper limbs (HP:0009823)1.84595351
147Aplasia of the phalanges of the hand (HP:0009802)1.84595351
148Aplasia involving bones of the extremities (HP:0009825)1.84595351
149Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.83957410
150Hypoplasia of the capital femoral epiphysis (HP:0003090)1.83653756
151Abnormality of molar (HP:0011077)1.82441989
152Abnormality of molar morphology (HP:0011070)1.82441989
153Pustule (HP:0200039)1.82071416
154Abnormal urine output (HP:0012590)1.81622525
155Abnormality of the dental pulp (HP:0006479)1.81183330
156Hyperacusis (HP:0010780)1.81012195
157Tarsal synostosis (HP:0008368)1.80411762
158Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.80252665
159Easy fatigability (HP:0003388)1.79697345
160Aplasia/hypoplasia of the uterus (HP:0008684)1.79450398
161Increased mean platelet volume (HP:0011877)1.78805157
162Patellar aplasia (HP:0006443)1.78395156
163Abnormality of renin-angiotensin system (HP:0000847)1.78042236
164Selective tooth agenesis (HP:0001592)1.76866088
165Congenital hepatic fibrosis (HP:0002612)1.76636078
166Hyperthyroidism (HP:0000836)1.76591970
167Abnormality of the aortic arch (HP:0012303)1.76553866
168Aplasia/Hypoplasia of the tongue (HP:0010295)1.75220821
169Tubulointerstitial nephritis (HP:0001970)1.74053417
170Limb-girdle muscle atrophy (HP:0003797)1.74034443
171Spinal rigidity (HP:0003306)1.73394463
172Postaxial foot polydactyly (HP:0001830)1.73201158
173Pterygium (HP:0001059)1.72754191
174Trismus (HP:0000211)1.72718161
175Vascular calcification (HP:0004934)1.72385649
176Abnormal pancreas size (HP:0012094)1.71825080
177Aplasia/Hypoplasia of the patella (HP:0006498)1.71817094
178Increased corneal curvature (HP:0100692)1.71620963
179Keratoconus (HP:0000563)1.71620963
180Abnormality of purine metabolism (HP:0004352)1.71242829
181Mildly elevated creatine phosphokinase (HP:0008180)1.70318031
182Furrowed tongue (HP:0000221)1.69808482
183Hyperuricemia (HP:0002149)1.68741992
184Increased purine levels (HP:0004368)1.68741992
185Mesangial abnormality (HP:0001966)1.68366493
186Abnormal hair laboratory examination (HP:0003328)1.68133673
187Abnormality of chloride homeostasis (HP:0011422)1.68121363
188Increased variability in muscle fiber diameter (HP:0003557)1.68018947
189Hemorrhage of the eye (HP:0011885)1.67209457
190Chronic bronchitis (HP:0004469)1.66729074
191Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.66049919
192Gait imbalance (HP:0002141)1.65816553
193Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.65803784
194Hyperventilation (HP:0002883)1.65761238
195Rectal prolapse (HP:0002035)1.65091564
196Abnormality of the gastric mucosa (HP:0004295)1.64432648

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK5.67910950
2ERBB45.43525740
3TTN5.35348969
4MST1R5.03259192
5MST44.25021106
6EPHA23.68467294
7IRAK32.77259718
8LMTK22.38399620
9DMPK2.35121518
10PIK3CG2.34778470
11MET2.12115493
12NUAK12.03164407
13TRIB31.95734409
14MAP3K21.86724804
15PAK21.77717429
16ADRBK21.66889694
17RIPK11.64928591
18PKN21.62827116
19LRRK21.54996903
20MUSK1.54602769
21KSR21.49555564
22FER1.49392393
23TESK11.40805363
24DDR21.40088426
25MAPK151.39809950
26PTK61.37412111
27ERN11.33137962
28MAP4K21.32686017
29TLK11.29578024
30EPHB21.22661634
31STK101.22115066
32EEF2K1.17774032
33FRK1.17392665
34INSRR1.16968728
35GRK11.13706673
36TYRO31.11362973
37MAP2K11.10759168
38PRKG21.09567735
39PTK21.06554617
40PAK31.05813775
41OXSR11.05784073
42MAP2K21.05083684
43IRAK11.02754421
44TNK21.02239646
45RPS6KB21.02187727
46EPHB11.00653026
47RPS6KA20.98408935
48PIK3CA0.94634428
49FLT30.91515197
50DAPK20.91297459
51PAK10.90795383
52NME10.88841618
53ROCK20.88185523
54CHUK0.87267423
55MAPKAPK30.86498556
56BCKDK0.84035730
57PRKCI0.83070128
58MAP3K90.82557208
59LATS10.82499482
60ROCK10.80224449
61RIPK40.79901607
62PDGFRB0.79889113
63PRKD20.79800224
64FGFR20.78398294
65CDK80.76087989
66CAMK2G0.74755028
67WNK10.74137358
68SIK20.73552120
69CDC42BPA0.72499224
70STK390.71973660
71BMPR1B0.70579483
72WNK30.70484762
73TGFBR20.67906450
74PINK10.67171191
75CASK0.66624623
76IRAK20.66278228
77TAOK30.65614660
78FGFR40.64113324
79DAPK30.63053623
80FYN0.62711221
81ADRBK10.61783362
82PRKCE0.59752799
83LIMK10.57870906
84ILK0.57728105
85ZAK0.57364868
86PAK40.55462862
87MAP3K30.54646598
88BMX0.54105541
89MINK10.54000814
90MAPK130.52926132
91RAF10.51827791
92ZAP700.50681828
93RPS6KC10.50247743
94RPS6KL10.50247743
95MATK0.49916473
96SIK10.49540579
97MAP3K80.48355909
98MARK20.48015093
99ERBB20.47583909
100PRKAA10.46168110
101IKBKB0.45676048
102CAMK2B0.45424144
103ICK0.44338250
104MAP2K40.44296896
105AKT30.43466293
106MAP2K60.43438753
107STK38L0.43213520
108MAP3K130.43152271
109PRKD30.42947309
110SRC0.41474958
111DYRK20.40956991
112WNK40.40228311
113CAMK2D0.40178628
114RPS6KA60.40154403
115MAP3K10.38483334
116GRK50.38383718
117NEK20.37620650
118PRKCZ0.37495149
119EPHA30.36893658
120PDK30.36343635
121PDK40.36343635
122FGFR10.36107930
123PDGFRA0.36046240
124PDK20.34898705
125GSK3A0.32406320
126IRAK40.32169590
127CSNK1A10.32062201
128MAPK80.32041782
129MTOR0.30658846
130STK380.29822009
131RET0.29569732
132MAPKAPK20.29171953
133MAP3K70.28655313
134PHKG10.26644597
135PHKG20.26644597
136RPS6KA10.26624719
137MAPKAPK50.25371577
138FGFR30.23457163
139KSR10.22497580
140PDPK10.22181991
141PRKACB0.21858522
142JAK20.21205054
143CSK0.20812177
144PRKCG0.20801226
145EGFR0.20163423
146CDK90.18775839
147TAOK10.18668574
148PRKAA20.18484155
149JAK10.17031764
150NTRK20.16631511
151PTK2B0.16478012
152TBK10.13458098
153PRKD10.13106648
154NTRK10.12750852

Predicted pathways (KEGG)

RankGene SetZ-score
1Collecting duct acid secretion_Homo sapiens_hsa049664.98058235
2Gastric acid secretion_Homo sapiens_hsa049714.66292354
3Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.20097974
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.64150037
5Fat digestion and absorption_Homo sapiens_hsa049753.57671525
6Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005123.16567532
7Cyanoamino acid metabolism_Homo sapiens_hsa004603.07894709
8Sulfur metabolism_Homo sapiens_hsa009203.01624802
9Chemical carcinogenesis_Homo sapiens_hsa052043.00726377
10Vitamin digestion and absorption_Homo sapiens_hsa049772.81981245
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.81086001
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.62688063
13Glutathione metabolism_Homo sapiens_hsa004802.55605496
14Linoleic acid metabolism_Homo sapiens_hsa005912.51619108
15Steroid hormone biosynthesis_Homo sapiens_hsa001402.40444299
16Fatty acid biosynthesis_Homo sapiens_hsa000612.16618387
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.02032642
18Vascular smooth muscle contraction_Homo sapiens_hsa042701.95087502
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.92480473
20Bladder cancer_Homo sapiens_hsa052191.86480791
21Phototransduction_Homo sapiens_hsa047441.84491355
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.62836107
23Pancreatic secretion_Homo sapiens_hsa049721.60108223
24Ether lipid metabolism_Homo sapiens_hsa005651.59152686
25Mineral absorption_Homo sapiens_hsa049781.59034560
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.51667908
27Ovarian steroidogenesis_Homo sapiens_hsa049131.41773751
28Sulfur relay system_Homo sapiens_hsa041221.34750404
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31296020
30Axon guidance_Homo sapiens_hsa043601.26700812
31Nicotine addiction_Homo sapiens_hsa050331.25691089
32Thyroid hormone synthesis_Homo sapiens_hsa049181.18815099
33Taste transduction_Homo sapiens_hsa047421.18359169
34Insulin secretion_Homo sapiens_hsa049111.13358938
35Histidine metabolism_Homo sapiens_hsa003401.12477583
36Arachidonic acid metabolism_Homo sapiens_hsa005901.12249806
37Tight junction_Homo sapiens_hsa045301.10362548
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.10335762
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.07572540
40Fatty acid degradation_Homo sapiens_hsa000711.04876925
41Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.01580995
42Notch signaling pathway_Homo sapiens_hsa043300.99646962
43Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.99557518
44ECM-receptor interaction_Homo sapiens_hsa045120.98299976
45Bile secretion_Homo sapiens_hsa049760.96508544
46Phenylalanine metabolism_Homo sapiens_hsa003600.94911274
47Hedgehog signaling pathway_Homo sapiens_hsa043400.93290244
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.92274854
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91861642
50Selenocompound metabolism_Homo sapiens_hsa004500.91628021
51Glycerolipid metabolism_Homo sapiens_hsa005610.90906590
52beta-Alanine metabolism_Homo sapiens_hsa004100.88412520
53Steroid biosynthesis_Homo sapiens_hsa001000.84043314
54Focal adhesion_Homo sapiens_hsa045100.82854933
55Lysine degradation_Homo sapiens_hsa003100.81802900
56Retinol metabolism_Homo sapiens_hsa008300.81468389
57N-Glycan biosynthesis_Homo sapiens_hsa005100.81343528
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78895799
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.72181267
60Proteoglycans in cancer_Homo sapiens_hsa052050.70159055
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69477390
62Glycerophospholipid metabolism_Homo sapiens_hsa005640.69180899
63Leukocyte transendothelial migration_Homo sapiens_hsa046700.68748689
64Peroxisome_Homo sapiens_hsa041460.68270515
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67978491
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67960510
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66143525
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66011349
69Glutamatergic synapse_Homo sapiens_hsa047240.65936369
70Salivary secretion_Homo sapiens_hsa049700.65603035
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62329646
72Adherens junction_Homo sapiens_hsa045200.62148888
73Propanoate metabolism_Homo sapiens_hsa006400.60770354
74Circadian entrainment_Homo sapiens_hsa047130.58212973
75Metabolic pathways_Homo sapiens_hsa011000.57883865
76Serotonergic synapse_Homo sapiens_hsa047260.57717245
77Amoebiasis_Homo sapiens_hsa051460.57003561
78Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56823245
79Basal transcription factors_Homo sapiens_hsa030220.55518039
80Nitrogen metabolism_Homo sapiens_hsa009100.54295222
81Morphine addiction_Homo sapiens_hsa050320.54030717
82Thyroid cancer_Homo sapiens_hsa052160.53993943
83Fructose and mannose metabolism_Homo sapiens_hsa000510.52672091
84Circadian rhythm_Homo sapiens_hsa047100.52198531
85Platelet activation_Homo sapiens_hsa046110.52129953
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47705524
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46748203
88Sphingolipid metabolism_Homo sapiens_hsa006000.45622126
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45535726
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45211265
91Regulation of autophagy_Homo sapiens_hsa041400.45084180
92RNA degradation_Homo sapiens_hsa030180.44758955
93Salmonella infection_Homo sapiens_hsa051320.43747334
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.43505515
95Protein digestion and absorption_Homo sapiens_hsa049740.43228851
96Fanconi anemia pathway_Homo sapiens_hsa034600.42006202
97Other glycan degradation_Homo sapiens_hsa005110.41338205
98Dorso-ventral axis formation_Homo sapiens_hsa043200.41036734
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.40994789
100Dilated cardiomyopathy_Homo sapiens_hsa054140.40384667
101Homologous recombination_Homo sapiens_hsa034400.40029791
102Calcium signaling pathway_Homo sapiens_hsa040200.39006593
103Tyrosine metabolism_Homo sapiens_hsa003500.38733743
104GABAergic synapse_Homo sapiens_hsa047270.38667047
105PPAR signaling pathway_Homo sapiens_hsa033200.38619617
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38049101
107One carbon pool by folate_Homo sapiens_hsa006700.37645344
108Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36932990
109Toxoplasmosis_Homo sapiens_hsa051450.36615157
110Pyruvate metabolism_Homo sapiens_hsa006200.35970721
111Dopaminergic synapse_Homo sapiens_hsa047280.35437893
112Hippo signaling pathway_Homo sapiens_hsa043900.34055819
113Carbon metabolism_Homo sapiens_hsa012000.33798056
114GnRH signaling pathway_Homo sapiens_hsa049120.33592967
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.33017461
116AMPK signaling pathway_Homo sapiens_hsa041520.32819136
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32799985
118Fatty acid metabolism_Homo sapiens_hsa012120.31872244
119Glucagon signaling pathway_Homo sapiens_hsa049220.29672805
120Small cell lung cancer_Homo sapiens_hsa052220.29450062
121Oxidative phosphorylation_Homo sapiens_hsa001900.27836803
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26859183
123Tryptophan metabolism_Homo sapiens_hsa003800.25935810
124VEGF signaling pathway_Homo sapiens_hsa043700.25565993
125Estrogen signaling pathway_Homo sapiens_hsa049150.25507537
126Starch and sucrose metabolism_Homo sapiens_hsa005000.25373503
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.24840801
128Oxytocin signaling pathway_Homo sapiens_hsa049210.24636425
129Pentose phosphate pathway_Homo sapiens_hsa000300.24371963
130Basal cell carcinoma_Homo sapiens_hsa052170.23655686
131Butanoate metabolism_Homo sapiens_hsa006500.23312536
132ABC transporters_Homo sapiens_hsa020100.22749362
133Endometrial cancer_Homo sapiens_hsa052130.21727623
134Galactose metabolism_Homo sapiens_hsa000520.20884024
135Lysosome_Homo sapiens_hsa041420.19797693
136Maturity onset diabetes of the young_Homo sapiens_hsa049500.19409057
137Shigellosis_Homo sapiens_hsa051310.18497715
138Caffeine metabolism_Homo sapiens_hsa002320.18099198
139Renin secretion_Homo sapiens_hsa049240.17876124
140Arginine biosynthesis_Homo sapiens_hsa002200.17703034
141Hepatitis C_Homo sapiens_hsa051600.16874517
142Melanogenesis_Homo sapiens_hsa049160.14336021
143Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.13538669
144Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.13405658
145African trypanosomiasis_Homo sapiens_hsa051430.13133327
146Insulin resistance_Homo sapiens_hsa049310.12876473
147Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.12134642

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