FER1L5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)8.73463498
2multicellular organism reproduction (GO:0032504)8.40688642
3epithelial cilium movement (GO:0003351)8.35752636
4axonemal dynein complex assembly (GO:0070286)8.34469978
5sperm-egg recognition (GO:0035036)8.20400106
6plasma membrane fusion (GO:0045026)8.17308971
7acrosome assembly (GO:0001675)7.85104485
8cell wall macromolecule metabolic process (GO:0044036)7.81321916
9cell wall macromolecule catabolic process (GO:0016998)7.81321916
10regulation of cilium movement (GO:0003352)7.54592657
11cell-cell recognition (GO:0009988)7.46692376
12cilium movement (GO:0003341)7.42007433
13binding of sperm to zona pellucida (GO:0007339)7.34492135
14spermatid development (GO:0007286)7.18358120
15reproduction (GO:0000003)7.11245246
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.10000037
17motile cilium assembly (GO:0044458)6.97802401
18piRNA metabolic process (GO:0034587)6.41786898
19male meiosis (GO:0007140)5.92413972
20single fertilization (GO:0007338)5.71852648
21synaptonemal complex organization (GO:0070193)5.62673825
22negative regulation of inclusion body assembly (GO:0090084)5.62457599
23ventricular system development (GO:0021591)5.43609783
24synaptonemal complex assembly (GO:0007130)5.34527112
25sperm capacitation (GO:0048240)5.20943839
26response to pheromone (GO:0019236)5.08178173
27behavioral response to nicotine (GO:0035095)5.01845380
28calcium ion-dependent exocytosis (GO:0017156)4.97096511
29fertilization (GO:0009566)4.79750458
30spermatogenesis (GO:0007283)4.66837495
31male gamete generation (GO:0048232)4.64689663
32male meiosis I (GO:0007141)4.54790517
33regulation of microtubule-based movement (GO:0060632)4.50229954
34microtubule depolymerization (GO:0007019)4.43227586
35monoubiquitinated protein deubiquitination (GO:0035520)4.38176962
36regulation of inclusion body assembly (GO:0090083)4.35646118
37organic cation transport (GO:0015695)4.32960330
38gamete generation (GO:0007276)4.29130900
39cellular process involved in reproduction in multicellular organism (GO:0022412)4.09040022
40germ cell development (GO:0007281)4.04742643
41seminiferous tubule development (GO:0072520)4.02502685
42tryptophan catabolic process (GO:0006569)3.95893901
43indole-containing compound catabolic process (GO:0042436)3.95893901
44indolalkylamine catabolic process (GO:0046218)3.95893901
45cell recognition (GO:0008037)3.93993303
46fucose catabolic process (GO:0019317)3.93872795
47L-fucose metabolic process (GO:0042354)3.93872795
48L-fucose catabolic process (GO:0042355)3.93872795
49microtubule severing (GO:0051013)3.87853773
50cellular ketone body metabolic process (GO:0046950)3.84273214
51DNA methylation involved in gamete generation (GO:0043046)3.70481056
52indolalkylamine metabolic process (GO:0006586)3.68829246
53meiosis I (GO:0007127)3.61449166
54meiotic nuclear division (GO:0007126)3.56627333
55protein polyglutamylation (GO:0018095)3.52604495
56ketone body metabolic process (GO:1902224)3.52246064
57chromosome organization involved in meiosis (GO:0070192)3.49627848
58nonmotile primary cilium assembly (GO:0035058)3.46245754
59detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.44317982
60tryptophan metabolic process (GO:0006568)3.42552151
61DNA deamination (GO:0045006)3.42039978
62cilium assembly (GO:0042384)3.38784232
63multicellular organismal reproductive process (GO:0048609)3.37379628
64left/right pattern formation (GO:0060972)3.32303179
65negative regulation of organelle assembly (GO:1902116)3.31268753
66regulation of chromatin binding (GO:0035561)3.27817675
67nuclear pore complex assembly (GO:0051292)3.27572955
68mitotic sister chromatid cohesion (GO:0007064)3.27235078
69protein localization to cilium (GO:0061512)3.26827458
70intraciliary transport (GO:0042073)3.24034387
71detection of light stimulus involved in visual perception (GO:0050908)3.21272519
72detection of light stimulus involved in sensory perception (GO:0050962)3.21272519
73gene silencing by RNA (GO:0031047)3.17147467
74genitalia morphogenesis (GO:0035112)3.16732061
75kynurenine metabolic process (GO:0070189)3.09832456
76microtubule-based movement (GO:0007018)3.04230265
77chromosome condensation (GO:0030261)3.03674823
78glycerol ether metabolic process (GO:0006662)3.01854322
79axoneme assembly (GO:0035082)3.01063371
80photoreceptor cell maintenance (GO:0045494)3.00955889
81negative regulation of telomere maintenance (GO:0032205)2.99751541
82positive regulation of catecholamine secretion (GO:0033605)2.97505369
83peptidyl-lysine dimethylation (GO:0018027)2.96420930
84membrane depolarization during action potential (GO:0086010)2.92082815
85amino-acid betaine transport (GO:0015838)2.90782471
86carnitine transport (GO:0015879)2.90782471
87DNA double-strand break processing (GO:0000729)2.89960995
88water-soluble vitamin biosynthetic process (GO:0042364)2.88872923
89RNA localization (GO:0006403)2.88728984
90retinal cone cell development (GO:0046549)2.88314150
91behavioral response to ethanol (GO:0048149)2.85609753
92regulation of action potential (GO:0098900)2.85426469
93response to acidic pH (GO:0010447)2.85211658
94carnitine transmembrane transport (GO:1902603)2.82036965
95synapsis (GO:0007129)2.79998730
96neuronal action potential (GO:0019228)2.78672038
97macroautophagy (GO:0016236)2.78202415
98rRNA methylation (GO:0031167)2.77826099
99protein K11-linked deubiquitination (GO:0035871)2.77377373
100glycolytic process (GO:0006096)2.75866893
101regulation of centriole replication (GO:0046599)2.75438965
102meiotic cell cycle (GO:0051321)2.74994327
103DNA packaging (GO:0006323)2.74993477
104peptidyl-glutamic acid modification (GO:0018200)2.74395359
105protein localization to Golgi apparatus (GO:0034067)2.73275544
106cellular biogenic amine catabolic process (GO:0042402)2.72722524
107amine catabolic process (GO:0009310)2.72722524
108neural tube formation (GO:0001841)2.72156811
109phosphatidylethanolamine metabolic process (GO:0046337)2.72017074
110indole-containing compound metabolic process (GO:0042430)2.70419127
111photoreceptor cell development (GO:0042461)2.69990377
112lactate metabolic process (GO:0006089)2.69669984
113ether metabolic process (GO:0018904)2.69648666
114multicellular organismal development (GO:0007275)2.69344439
115gene silencing (GO:0016458)2.68879294
116reflex (GO:0060004)2.67650214
117coenzyme catabolic process (GO:0009109)2.67371730
118mannosylation (GO:0097502)2.66455616
119phosphatidylethanolamine biosynthetic process (GO:0006646)2.66290533
120rRNA catabolic process (GO:0016075)2.65713690
121cellular component assembly involved in morphogenesis (GO:0010927)2.63555866
122single strand break repair (GO:0000012)2.63171817
123polyol catabolic process (GO:0046174)2.62310619
124nephron tubule morphogenesis (GO:0072078)2.61538908
125nephron epithelium morphogenesis (GO:0072088)2.61538908
126sister chromatid cohesion (GO:0007062)2.60422171
127spermatid nucleus differentiation (GO:0007289)2.59520414
128pore complex assembly (GO:0046931)2.58642739
129sexual reproduction (GO:0019953)2.58193360
130cellular hyperosmotic response (GO:0071474)2.57783061
131regulation of cilium assembly (GO:1902017)2.57546583
132sulfation (GO:0051923)2.57012145
133G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.56494548
134cornea development in camera-type eye (GO:0061303)2.56375306
135negative regulation of cytosolic calcium ion concentration (GO:0051481)2.55737560
136positive regulation of histone deacetylation (GO:0031065)2.53687094
137establishment of protein localization to Golgi (GO:0072600)2.53424325
138rRNA modification (GO:0000154)2.52293810
139NLS-bearing protein import into nucleus (GO:0006607)2.52153300
140chaperone-mediated protein complex assembly (GO:0051131)2.51998243
141centriole replication (GO:0007099)2.51266030
142smoothened signaling pathway (GO:0007224)2.50177744
143detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.49220388
144positive regulation of glycolytic process (GO:0045821)2.48056022
145preassembly of GPI anchor in ER membrane (GO:0016254)2.47733365
146regulation of meiosis I (GO:0060631)2.46745147
147cilium morphogenesis (GO:0060271)2.46444459
148somite development (GO:0061053)2.46051098
149eye photoreceptor cell development (GO:0042462)2.45443953
150mitochondrial respiratory chain complex I assembly (GO:0032981)2.44259193
151NADH dehydrogenase complex assembly (GO:0010257)2.44259193
152mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.44259193
153microtubule polymerization or depolymerization (GO:0031109)2.42936851
154determination of left/right symmetry (GO:0007368)2.42098881
155negative regulation of reactive oxygen species metabolic process (GO:2000378)2.41557030
156spinal cord motor neuron differentiation (GO:0021522)2.41526457
157regulation of dopamine secretion (GO:0014059)2.41438495
158nucleus organization (GO:0006997)2.40932458
159cilium organization (GO:0044782)2.39612193
160retrograde transport, vesicle recycling within Golgi (GO:0000301)2.32867615
161protein targeting to Golgi (GO:0000042)2.31808850
162alditol metabolic process (GO:0019400)2.31508322
163fusion of sperm to egg plasma membrane (GO:0007342)10.6285731
164cilium or flagellum-dependent cell motility (GO:0001539)10.5577620
165sperm motility (GO:0030317)10.0312208

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.30317956
2EZH2_22144423_ChIP-Seq_EOC_Human5.19364746
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.39147809
4VDR_22108803_ChIP-Seq_LS180_Human3.25342830
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.99628995
6GBX2_23144817_ChIP-Seq_PC3_Human2.93937296
7IGF1R_20145208_ChIP-Seq_DFB_Human2.91860931
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.61442051
9FUS_26573619_Chip-Seq_HEK293_Human2.44955194
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.34559356
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.32552074
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.25849477
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.25774551
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.20601102
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.11060178
16GATA1_26923725_Chip-Seq_HPCs_Mouse2.06667579
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.05331293
18ELK4_26923725_Chip-Seq_MESODERM_Mouse2.05063071
19ER_23166858_ChIP-Seq_MCF-7_Human2.03485199
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.03269466
21P300_19829295_ChIP-Seq_ESCs_Human2.02504270
22EWS_26573619_Chip-Seq_HEK293_Human1.90856962
23CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.84897193
24REST_21632747_ChIP-Seq_MESCs_Mouse1.78638530
25UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.75820318
26POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.71054730
27TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71054730
28WDR5_24793694_ChIP-Seq_LNCAP_Human1.66713847
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.63278290
30BCAT_22108803_ChIP-Seq_LS180_Human1.57906750
31AR_25329375_ChIP-Seq_VCAP_Human1.56933201
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52372333
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51949275
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.51789862
35MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.50945239
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49799485
37TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.44753756
38IRF1_19129219_ChIP-ChIP_H3396_Human1.42634861
39DROSHA_22980978_ChIP-Seq_HELA_Human1.42518607
40KLF5_20875108_ChIP-Seq_MESCs_Mouse1.42375444
41SOX2_19829295_ChIP-Seq_ESCs_Human1.41658381
42NANOG_19829295_ChIP-Seq_ESCs_Human1.41658381
43MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40694530
44TP53_22573176_ChIP-Seq_HFKS_Human1.40620354
45TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39266280
46RUNX2_22187159_ChIP-Seq_PCA_Human1.36421767
47FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36165673
48TCF4_22108803_ChIP-Seq_LS180_Human1.30752259
49NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30636715
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.29452624
51GATA3_21878914_ChIP-Seq_MCF-7_Human1.29052303
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.28817987
53AR_21572438_ChIP-Seq_LNCaP_Human1.27831085
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27279389
55ZNF274_21170338_ChIP-Seq_K562_Hela1.26048053
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25695998
57GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24384582
58SMAD4_21741376_ChIP-Seq_EPCs_Human1.24173910
59PRDM14_20953172_ChIP-Seq_ESCs_Human1.24035305
60RUNX1_26923725_Chip-Seq_HPCs_Mouse1.24028263
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22590311
62FOXA1_27270436_Chip-Seq_PROSTATE_Human1.22337761
63FOXA1_25329375_ChIP-Seq_VCAP_Human1.22337761
64GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.22009167
65HOXB7_26014856_ChIP-Seq_BT474_Human1.21050847
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20990757
67CBP_20019798_ChIP-Seq_JUKART_Human1.20990757
68* NCOR_22424771_ChIP-Seq_293T_Human1.20151375
69ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18367405
70RARB_27405468_Chip-Seq_BRAIN_Mouse1.17983480
71PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17206019
72NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15142232
73NANOG_20526341_ChIP-Seq_ESCs_Human1.14778966
74AUTS2_25519132_ChIP-Seq_293T-REX_Human1.14714050
75EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14636026
76MYC_19829295_ChIP-Seq_ESCs_Human1.13880077
77SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12287863
78MYC_18940864_ChIP-ChIP_HL60_Human1.12225349
79STAT1_17558387_ChIP-Seq_HELA_Human1.12003686
80ERA_21632823_ChIP-Seq_H3396_Human1.11520873
81FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10853239
82CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.10599490
83KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10157184
84AR_20517297_ChIP-Seq_VCAP_Human1.09027782
85PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08867795
86KDM2B_26808549_Chip-Seq_REH_Human1.08445067
87RNF2_27304074_Chip-Seq_NSC_Mouse1.08156356
88CDX2_22108803_ChIP-Seq_LS180_Human1.07853709
89RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06790590
90NOTCH1_21737748_ChIP-Seq_TLL_Human1.05061918
91FLI1_21867929_ChIP-Seq_TH2_Mouse1.04874598
92TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03960782
93SMAD3_21741376_ChIP-Seq_ESCs_Human1.03700238
94REST_18959480_ChIP-ChIP_MESCs_Mouse1.03672657
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02937986
96SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02450174
97RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02016754
98OCT1_27270436_Chip-Seq_PROSTATE_Human1.01560180
99EZH2_27294783_Chip-Seq_NPCs_Mouse1.01332947
100CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00086258
101TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99993394
102* OCT4_20526341_ChIP-Seq_ESCs_Human0.99897553
103GABP_17652178_ChIP-ChIP_JURKAT_Human0.99573850
104GF1_26923725_Chip-Seq_HPCs_Mouse0.99041718
105TCF7_22412390_ChIP-Seq_EML_Mouse0.98607150
106OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98194363
107CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97958591
108SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97676756
109GATA1_19941827_ChIP-Seq_MEL86_Mouse0.97334557
110ARNT_22903824_ChIP-Seq_MCF-7_Human0.97211925
111FOXH1_21741376_ChIP-Seq_EPCs_Human0.96895534
112* KDM2B_26808549_Chip-Seq_DND41_Human0.96687455
113NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96601364
114PHF8_20622853_ChIP-Seq_HELA_Human0.95986192
115TAF15_26573619_Chip-Seq_HEK293_Human0.95877453
116TBL1_22424771_ChIP-Seq_293T_Human0.95325794
117KLF4_19829295_ChIP-Seq_ESCs_Human0.95221235
118FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94219545
119TCF4_23295773_ChIP-Seq_U87_Human0.93929582
120FLI1_27457419_Chip-Seq_LIVER_Mouse0.93016540
121SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91760551
122KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.91720853
123LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.91706735
124SMAD3_21741376_ChIP-Seq_EPCs_Human0.89739084
125AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89104604
126MYC_27129775_Chip-Seq_CORNEA_Mouse0.89072422
127EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88856129
128SMAD4_21799915_ChIP-Seq_A2780_Human0.88636382
129SMC4_20622854_ChIP-Seq_HELA_Human0.87641189
130PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86703515
131MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.86074813
132P53_21459846_ChIP-Seq_SAOS-2_Human0.86068249
133TET1_21490601_ChIP-Seq_MESCs_Mouse0.85917030
134KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.85172919
135PCGF2_27294783_Chip-Seq_NPCs_Mouse0.83499979
136NFYB_21822215_ChIP-Seq_K562_Human0.83456181
137OCT4_19829295_ChIP-Seq_ESCs_Human0.83280601
138TAL1_26923725_Chip-Seq_HPCs_Mouse0.81754275
139ELF1_20517297_ChIP-Seq_JURKAT_Human0.81549406
140PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.80581353
141NFE2_27457419_Chip-Seq_LIVER_Mouse0.79940656
142GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79720626
143STAT3_23295773_ChIP-Seq_U87_Human0.79441381
144TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.78872401
145CBX2_27304074_Chip-Seq_ESCs_Mouse0.78589413
146GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78282909
147NANOG_18555785_Chip-Seq_ESCs_Mouse0.77416396
148SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76515258
149PCGF2_27294783_Chip-Seq_ESCs_Mouse0.76278141
150ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.76222690
151KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.76175246
152GATA3_27048872_Chip-Seq_THYMUS_Human0.76039044
153TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.76020452
154ETV1_20927104_ChIP-Seq_GIST48_Human0.75917262
155SOX2_22085726_ChIP-Seq_NPCs_Mouse0.75881907
156EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.75067149
157MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.74700477
158SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.74624524
159SOX2_21211035_ChIP-Seq_LN229_Human0.74561527
160* FOXA2_19822575_ChIP-Seq_HepG2_Human0.74467866
161EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.74407304
162VDR_24787735_ChIP-Seq_THP-1_Human0.74194198
163SMRT_27268052_Chip-Seq_Bcells_Human0.73213571

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive4.62196192
2MP0001929_abnormal_gametogenesis4.08096531
3MP0008877_abnormal_DNA_methylation3.46661009
4MP0001984_abnormal_olfaction3.44838577
5MP0005670_abnormal_white_adipose3.07796042
6MP0005551_abnormal_eye_electrophysiolog2.63536656
7MP0002161_abnormal_fertility/fecundity2.61141279
8MP0000569_abnormal_digit_pigmentation2.58615653
9MP0004859_abnormal_synaptic_plasticity2.55123556
10MP0002210_abnormal_sex_determination2.45971825
11MP0002653_abnormal_ependyma_morphology2.38949903
12MP0003646_muscle_fatigue2.34084488
13MP0001145_abnormal_male_reproductive2.11478001
14MP0003195_calcinosis2.11288136
15MP0005410_abnormal_fertilization11.6318320
16MP0006292_abnormal_olfactory_placode1.97551003
17MP0003136_yellow_coat_color1.93776801
18MP0003878_abnormal_ear_physiology1.92972360
19MP0005377_hearing/vestibular/ear_phenot1.92972360
20MP0005646_abnormal_pituitary_gland1.86423660
21MP0005253_abnormal_eye_physiology1.85797870
22MP0003880_abnormal_central_pattern1.85409226
23MP0001986_abnormal_taste_sensitivity1.84894048
24MP0000653_abnormal_sex_gland1.84195684
25MP0002876_abnormal_thyroid_physiology1.82354568
26MP0002837_dystrophic_cardiac_calcinosis1.78186320
27MP0006072_abnormal_retinal_apoptosis1.76770839
28MP0001501_abnormal_sleep_pattern1.74627792
29MP0008961_abnormal_basal_metabolism1.74185743
30MP0008875_abnormal_xenobiotic_pharmacok1.61862636
31MP0002638_abnormal_pupillary_reflex1.61521705
32MP0002234_abnormal_pharynx_morphology1.61175127
33MP0006276_abnormal_autonomic_nervous1.59318333
34MP0008872_abnormal_physiological_respon1.56618201
35MP0004133_heterotaxia1.56350065
36MP0004233_abnormal_muscle_weight1.56320321
37MP0002163_abnormal_gland_morphology1.56195385
38MP0002272_abnormal_nervous_system1.52578746
39MP0001485_abnormal_pinna_reflex1.51914401
40MP0000427_abnormal_hair_cycle1.48842627
41MP0005379_endocrine/exocrine_gland_phen1.47841798
42MP0001529_abnormal_vocalization1.45612797
43MP0004130_abnormal_muscle_cell1.41207733
44MP0004043_abnormal_pH_regulation1.40885577
45MP0005645_abnormal_hypothalamus_physiol1.40369713
46MP0009046_muscle_twitch1.38826046
47MP0005394_taste/olfaction_phenotype1.35647909
48MP0005499_abnormal_olfactory_system1.35647909
49MP0002822_catalepsy1.34985914
50MP0008995_early_reproductive_senescence1.34137895
51MP0002282_abnormal_trachea_morphology1.33066717
52MP0003635_abnormal_synaptic_transmissio1.30353119
53MP0000631_abnormal_neuroendocrine_gland1.29878542
54MP0010386_abnormal_urinary_bladder1.24914496
55MP0002938_white_spotting1.24822958
56MP0001905_abnormal_dopamine_level1.23439787
57MP0002139_abnormal_hepatobiliary_system1.21401832
58MP0000372_irregular_coat_pigmentation1.20972668
59MP0005174_abnormal_tail_pigmentation1.20742365
60MP0004142_abnormal_muscle_tone1.20333235
61MP0005623_abnormal_meninges_morphology1.20187081
62MP0002909_abnormal_adrenal_gland1.17759383
63MP0005389_reproductive_system_phenotype1.16716112
64MP0003329_amyloid_beta_deposits1.16676884
65MP0003718_maternal_effect1.15198458
66MP0005666_abnormal_adipose_tissue1.13931361
67MP0003787_abnormal_imprinting1.13547347
68MP0002063_abnormal_learning/memory/cond1.12448680
69MP0001970_abnormal_pain_threshold1.09567971
70MP0002733_abnormal_thermal_nociception1.07608759
71MP0001765_abnormal_ion_homeostasis1.07585739
72MP0008789_abnormal_olfactory_epithelium1.06630685
73MP0005365_abnormal_bile_salt1.05768464
74MP0004270_analgesia1.05639548
75MP0000566_synostosis1.02312288
76MP0004811_abnormal_neuron_physiology0.99809518
77MP0000026_abnormal_inner_ear0.99488358
78MP0005195_abnormal_posterior_eye0.98097122
79MP0004147_increased_porphyrin_level0.97123559
80MP0002138_abnormal_hepatobiliary_system0.96283483
81MP0008775_abnormal_heart_ventricle0.95502381
82MP0003121_genomic_imprinting0.94563608
83MP0001963_abnormal_hearing_physiology0.92510523
84MP0002160_abnormal_reproductive_system0.92486734
85MP0003122_maternal_imprinting0.90727345
86MP0002752_abnormal_somatic_nervous0.90473607
87MP0004885_abnormal_endolymph0.90234695
88MP0005360_urolithiasis0.90102336
89MP0003879_abnormal_hair_cell0.89303220
90MP0002229_neurodegeneration0.88858366
91MP0003011_delayed_dark_adaptation0.88813787
92MP0000230_abnormal_systemic_arterial0.87823023
93MP0005084_abnormal_gallbladder_morpholo0.87739011
94MP0003633_abnormal_nervous_system0.87412418
95MP0004134_abnormal_chest_morphology0.86804386
96MP0003045_fibrosis0.85503394
97MP0009278_abnormal_bone_marrow0.84632423
98MP0003119_abnormal_digestive_system0.84017445
99MP0002102_abnormal_ear_morphology0.83352686
100MP0003656_abnormal_erythrocyte_physiolo0.82958132
101MP0002971_abnormal_brown_adipose0.82792817
102MP0002095_abnormal_skin_pigmentation0.82522504
103MP0002928_abnormal_bile_duct0.82485360
104MP0004145_abnormal_muscle_electrophysio0.82250626
105MP0001324_abnormal_eye_pigmentation0.81642152
106MP0001293_anophthalmia0.81562059
107MP0005386_behavior/neurological_phenoty0.81537453
108MP0004924_abnormal_behavior0.81537453
109MP0008569_lethality_at_weaning0.80622531
110MP0000604_amyloidosis0.80237910
111MP0005167_abnormal_blood-brain_barrier0.80125506
112MP0001764_abnormal_homeostasis0.79742842
113MP0000538_abnormal_urinary_bladder0.77869248
114MP0004858_abnormal_nervous_system0.77712340
115MP0004215_abnormal_myocardial_fiber0.77584452
116MP0005391_vision/eye_phenotype0.77304459
117MP0010329_abnormal_lipoprotein_level0.76609711
118MP0002152_abnormal_brain_morphology0.75616650
119MP0003690_abnormal_glial_cell0.75460425
120MP0003631_nervous_system_phenotype0.73936176
121MP0002269_muscular_atrophy0.72419087
122MP0002572_abnormal_emotion/affect_behav0.72042917
123MP0005248_abnormal_Harderian_gland0.71257331
124MP0005076_abnormal_cell_differentiation0.71224686
125MP0000751_myopathy0.70533649
126MP0009672_abnormal_birth_weight0.69297083
127MP0002184_abnormal_innervation0.69174405
128MP0003861_abnormal_nervous_system0.68622840
129MP0003303_peritoneal_inflammation0.68113594
130MP0009780_abnormal_chondrocyte_physiolo0.66360211
131MP0010030_abnormal_orbit_morphology0.65482528
132MP0004036_abnormal_muscle_relaxation0.65103931
133MP0009115_abnormal_fat_cell0.64971889
134MP0003252_abnormal_bile_duct0.63135856
135MP0002064_seizures0.62891563
136MP0002736_abnormal_nociception_after0.62369456
137MP0002557_abnormal_social/conspecific_i0.62056590
138MP0005375_adipose_tissue_phenotype0.62024401
139MP0002735_abnormal_chemical_nociception0.61582894
140MP0009745_abnormal_behavioral_response0.61387931
141MP0001440_abnormal_grooming_behavior0.60166908
142MP0005423_abnormal_somatic_nervous0.57049534
143MP0003632_abnormal_nervous_system0.55081641
144MP0005334_abnormal_fat_pad0.54740168
145MP0000955_abnormal_spinal_cord0.51959099
146MP0009703_decreased_birth_body0.51291482
147MP0003699_abnormal_female_reproductive0.50426106
148MP0010094_abnormal_chromosome_stability0.49951166
149MP0004742_abnormal_vestibular_system0.49413879
150MP0002882_abnormal_neuron_morphology0.48104003
151MP0010307_abnormal_tumor_latency0.48074457
152MP0001270_distended_abdomen0.47486300
153MP0002067_abnormal_sensory_capabilities0.46260609
154MP0001968_abnormal_touch/_nociception0.46122270
155MP0003300_gastrointestinal_ulcer0.45893985
156MP0002970_abnormal_white_adipose0.45335970
157MP0001486_abnormal_startle_reflex0.45158504
158MP0004185_abnormal_adipocyte_glucose0.43768177
159MP0004808_abnormal_hematopoietic_stem0.43669234
160MP0008770_decreased_survivor_rate0.43434570
161MP0000747_muscle_weakness0.42746804
162MP0003075_altered_response_to0.42263212
163MP0003705_abnormal_hypodermis_morpholog0.40795258
164MP0000778_abnormal_nervous_system0.40708121

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)9.67277299
2Absent/shortened dynein arms (HP:0200106)9.67277299
3Abnormal respiratory motile cilium physiology (HP:0012261)7.17664403
4Abnormal respiratory motile cilium morphology (HP:0005938)6.54329418
5Abnormal respiratory epithelium morphology (HP:0012253)6.54329418
6Rhinitis (HP:0012384)6.03901127
7Chronic bronchitis (HP:0004469)5.83675458
8Abnormal ciliary motility (HP:0012262)5.55392862
9Nasal polyposis (HP:0100582)5.07012139
10Infertility (HP:0000789)4.78690073
11Pancreatic fibrosis (HP:0100732)4.55411162
12Pancreatic cysts (HP:0001737)4.52077946
13True hermaphroditism (HP:0010459)4.21545925
14Abnormality of the nasal mucosa (HP:0000433)3.99016984
15Bronchitis (HP:0012387)3.72508401
16Chronic hepatic failure (HP:0100626)3.68444632
17Bronchiectasis (HP:0002110)3.66668181
18Congenital stationary night blindness (HP:0007642)3.63678356
19Attenuation of retinal blood vessels (HP:0007843)3.56484743
20Facial hemangioma (HP:0000329)3.54050347
21Male infertility (HP:0003251)3.47311700
22Nephronophthisis (HP:0000090)3.44205927
23Type II lissencephaly (HP:0007260)3.40543192
24Heterotopia (HP:0002282)3.22569851
25Abnormal rod and cone electroretinograms (HP:0008323)3.20903038
26Cystic liver disease (HP:0006706)3.17385918
27Abnormality of the renal cortex (HP:0011035)3.14646006
28Polydipsia (HP:0001959)3.13150981
29Abnormal drinking behavior (HP:0030082)3.13150981
30Medial flaring of the eyebrow (HP:0010747)3.11316986
31Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.99524014
32Recurrent otitis media (HP:0000403)2.96390361
33Pendular nystagmus (HP:0012043)2.74886325
34Cerebellar dysplasia (HP:0007033)2.67162829
35Absent rod-and cone-mediated responses on ERG (HP:0007688)2.66730456
36Recurrent sinusitis (HP:0011108)2.63204225
37Abolished electroretinogram (ERG) (HP:0000550)2.63154324
38Male pseudohermaphroditism (HP:0000037)2.60391265
39Abnormality of the lower motor neuron (HP:0002366)2.59675018
40Polyuria (HP:0000103)2.57589194
41Abnormality of the renal medulla (HP:0100957)2.55846021
42Occipital encephalocele (HP:0002085)2.54915255
43Bony spicule pigmentary retinopathy (HP:0007737)2.54280178
44Sclerocornea (HP:0000647)2.49614249
45Abnormal biliary tract physiology (HP:0012439)2.49217736
46Bile duct proliferation (HP:0001408)2.49217736
47Aplasia/Hypoplasia of the tongue (HP:0010295)2.48584544
48Anencephaly (HP:0002323)2.48081509
49Gait imbalance (HP:0002141)2.45842801
50Hyperventilation (HP:0002883)2.45530023
51Congenital primary aphakia (HP:0007707)2.43159137
52Tubulointerstitial nephritis (HP:0001970)2.40823686
53Congenital hepatic fibrosis (HP:0002612)2.39865112
54Large for gestational age (HP:0001520)2.35342271
55Decreased central vision (HP:0007663)2.35163797
56Recurrent bronchitis (HP:0002837)2.31730364
57Hyperacusis (HP:0010780)2.31653305
58Inability to walk (HP:0002540)2.29093153
59Hepatoblastoma (HP:0002884)2.28325251
60Aplasia/hypoplasia of the uterus (HP:0008684)2.26924208
61Abnormality of macular pigmentation (HP:0008002)2.22296265
62Absent frontal sinuses (HP:0002688)2.22212799
63Gaze-evoked nystagmus (HP:0000640)2.22133370
64Nephrogenic diabetes insipidus (HP:0009806)2.21794528
65Optic nerve hypoplasia (HP:0000609)2.18932472
66Abnormality of midbrain morphology (HP:0002418)2.18818080
67Molar tooth sign on MRI (HP:0002419)2.18818080
68Abnormal urine output (HP:0012590)2.15676498
69Microglossia (HP:0000171)2.13281680
70Increased density of long bones (HP:0006392)2.12838223
71Abnormal spermatogenesis (HP:0008669)2.12568615
72Hypoplasia of the uterus (HP:0000013)2.11847944
73Progressive cerebellar ataxia (HP:0002073)2.11846531
74Hypothermia (HP:0002045)2.11371332
75Lissencephaly (HP:0001339)2.10824309
76Increased corneal curvature (HP:0100692)2.10572042
77Keratoconus (HP:0000563)2.10572042
78Renal cortical cysts (HP:0000803)2.06992482
79Furrowed tongue (HP:0000221)2.05632545
80Short 4th metacarpal (HP:0010044)2.05572362
81Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.05572362
82Retinal dysplasia (HP:0007973)2.05024429
83Short ribs (HP:0000773)2.02486150
84Ketosis (HP:0001946)2.01464914
85Impulsivity (HP:0100710)2.00634874
86Elfin facies (HP:0004428)2.00213019
87Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.0740548
88Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.99273681
89Spastic tetraparesis (HP:0001285)1.98869219
90Chorioretinal atrophy (HP:0000533)1.98748065
91Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.98514375
92Abnormality of alanine metabolism (HP:0010916)1.98514375
93Hyperalaninemia (HP:0003348)1.98514375
94Severe visual impairment (HP:0001141)1.97885360
95Genital tract atresia (HP:0001827)1.97455036
96Congenital sensorineural hearing impairment (HP:0008527)1.97297332
97Absent speech (HP:0001344)1.97231169
98Renovascular hypertension (HP:0100817)1.97044933
99Hypoplastic labia majora (HP:0000059)1.94846023
100Febrile seizures (HP:0002373)1.92488343
101Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.90356610
102Abnormality of renal excretion (HP:0011036)1.89109572
103Acute necrotizing encephalopathy (HP:0006965)1.88274193
104Broad-based gait (HP:0002136)1.88227725
105Abnormality of the renal collecting system (HP:0004742)1.86505263
106Epiphyseal dysplasia (HP:0002656)1.85119755
107Protruding tongue (HP:0010808)1.85065562
108Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.84967805
109Short 1st metacarpal (HP:0010034)1.84967805
110Amyotrophic lateral sclerosis (HP:0007354)1.84344467
111Vaginal atresia (HP:0000148)1.84220063
112Optic disc pallor (HP:0000543)1.83877691
113Decreased electroretinogram (ERG) amplitude (HP:0000654)1.83142810
114Abnormality of the diencephalon (HP:0010662)1.82652638
115Aplasia/Hypoplasia of the uvula (HP:0010293)1.82576852
116Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.81103099
117Absent epiphyses (HP:0010577)1.81103099
118Poor coordination (HP:0002370)1.80856445
119Progressive inability to walk (HP:0002505)1.80166537
120Tubulointerstitial abnormality (HP:0001969)1.79353060
121Short femoral neck (HP:0100864)1.77803717
122Global brain atrophy (HP:0002283)1.76533045
123Abnormality of the labia majora (HP:0012881)1.76263659
124Progressive macrocephaly (HP:0004481)1.76140547
125Pachygyria (HP:0001302)1.74559478
126Atonic seizures (HP:0010819)1.74394545
127Preaxial hand polydactyly (HP:0001177)1.74131620
128Increased CSF lactate (HP:0002490)1.74106739
129Long clavicles (HP:0000890)1.73498194
130Insomnia (HP:0100785)1.73269507
131Abnormality of the pubic bones (HP:0003172)1.73118077
132Intestinal atresia (HP:0011100)1.72900322
133Tubular atrophy (HP:0000092)1.72583995
134Mitochondrial inheritance (HP:0001427)1.72477639
135Abnormality of the ileum (HP:0001549)1.71663598
136Aplasia/Hypoplasia of the tibia (HP:0005772)1.71358596
137Thyroid-stimulating hormone excess (HP:0002925)1.71321663
138Hypomagnesemia (HP:0002917)1.70040231
139Methylmalonic aciduria (HP:0012120)1.69674566
140Abnormality of ocular smooth pursuit (HP:0000617)1.67151754
141Abnormal gallbladder physiology (HP:0012438)1.67147029
142Cholecystitis (HP:0001082)1.67147029
143Postaxial foot polydactyly (HP:0001830)1.67001750
144Disinhibition (HP:0000734)1.64930065
145Abnormality of lateral ventricle (HP:0030047)1.61278709
146Truncal obesity (HP:0001956)1.60866653
147Azoospermia (HP:0000027)1.60359163
148Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.60232343
149Abnormality of the labia minora (HP:0012880)1.60050338
150Hypoplastic ischia (HP:0003175)1.59608620
151Dysmetric saccades (HP:0000641)1.57464011
152Impaired smooth pursuit (HP:0007772)1.56992662
153Abnormality of the 1st metacarpal (HP:0010009)1.56565955
154Mutism (HP:0002300)1.55495959
155Hypoplasia of the capital femoral epiphysis (HP:0003090)1.55144395
156Flat acetabular roof (HP:0003180)1.54069739
157Irregular epiphyses (HP:0010582)1.53653951
158Postaxial hand polydactyly (HP:0001162)1.52699472
159Hemiparesis (HP:0001269)1.50149458
160Arthropathy (HP:0003040)1.48547289
161Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.46826077
162Urinary urgency (HP:0000012)1.46224064
163Short phalanx of the thumb (HP:0009660)1.45306139
164Cerebral inclusion bodies (HP:0100314)1.45263433
165Abnormality of the 4th metacarpal (HP:0010012)1.45013193
166Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.44463117
167Aplasia/Hypoplasia of the sternum (HP:0006714)1.43287787
168Flattened epiphyses (HP:0003071)1.43243214
169Increased nuchal translucency (HP:0010880)1.42726430
170Hand muscle atrophy (HP:0009130)1.42199630
171Toxemia of pregnancy (HP:0100603)1.41745875
172Postural instability (HP:0002172)1.40742938
173Abnormal tarsal ossification (HP:0008369)1.39080130
174Exercise-induced myalgia (HP:0003738)1.37990597
175Neuronal loss in central nervous system (HP:0002529)1.37409044
176Ulnar deviation of the wrist (HP:0003049)1.35102702
177Abnormality of the aortic arch (HP:0012303)1.34107568
178Bell-shaped thorax (HP:0001591)1.34014910
179Asymmetric septal hypertrophy (HP:0001670)1.32844308
180Abnormality of the ischium (HP:0003174)1.32163641
181Inappropriate behavior (HP:0000719)1.32148388
182Volvulus (HP:0002580)1.31875812

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK36.24305329
2PDK46.24305329
3FRK5.51153818
4PRKD34.70538047
5PDK23.62109723
6TESK13.58186333
7ICK3.40391176
8MAP4K23.15162384
9ADRBK23.01291223
10ZAK2.81815602
11BMPR1B2.77225942
12PNCK2.60941308
13WNK32.47253782
14INSRR2.42910829
15BCKDK2.30523749
16EEF2K2.27832258
17TLK12.22676642
18GRK12.16467891
19LATS11.89972949
20SIK21.89095214
21PTK2B1.85033484
22TRIB31.82500189
23STK381.81254439
24CAMK1G1.78918862
25CASK1.60024696
26MARK11.59057737
27NEK21.57187013
28DYRK1B1.53439120
29MAPK131.51178696
30TXK1.45174882
31OXSR11.43967934
32MAP2K71.43367143
33TRIM281.42751351
34STK38L1.40483608
35EIF2AK31.36160106
36ACVR1B1.34237794
37CDK121.31060061
38MAP3K101.29683685
39MAPK151.24470438
40MARK31.20463656
41STK31.17843287
42LMTK21.14597855
43PDK11.12864749
44BMPR21.10867506
45MARK21.10696372
46TAOK11.08620663
47MKNK21.05733986
48STK161.01083770
49CAMKK11.00956104
50DYRK20.96482994
51PAK30.96323957
52TIE10.94823638
53TYRO30.94206397
54CSNK1G10.93598971
55CSNK1G30.92960322
56NUAK10.92891342
57RPS6KA50.91768258
58ADRBK10.91516495
59BCR0.91211218
60MAP3K90.90990355
61TGFBR10.90881404
62PRKCE0.90548977
63VRK10.89129427
64CSNK1A1L0.89076610
65LATS20.88620397
66DMPK0.88148233
67MTOR0.86489243
68DAPK20.86348140
69STK240.85467265
70FGFR20.83957390
71SGK30.83427092
72NTRK20.77616787
73TNIK0.77455329
74PRKCQ0.74430413
75WNK40.72827539
76RIPK10.71612902
77BRSK20.70963511
78PKN20.69452935
79MAP3K40.69010874
80MUSK0.66777707
81EPHA40.65475335
82OBSCN0.64852996
83WNK10.63399605
84MAPKAPK50.61625750
85ERBB30.60850275
86PRKAA10.58989364
87STK110.57438809
88PTK60.56933703
89MINK10.56656056
90NTRK30.56561345
91PDPK10.53795602
92RIPK40.51838347
93CDC70.50910619
94CAMK1D0.49870344
95MAPKAPK30.48629602
96PRKCH0.48543768
97PRKAA20.47516340
98MKNK10.47480532
99PLK40.46676261
100CSNK1A10.46526271
101MAP3K50.46064779
102SGK20.45905088
103PLK30.45611342
104CAMK10.45507472
105MAPK100.45122465
106GRK70.43835941
107PIK3CA0.43691096
108PRKG10.43053365
109CDK30.42878260
110IKBKB0.42306843
111PDGFRB0.42156154
112NME10.40812302
113RPS6KA20.40707629
114PKN10.39837621
115MAP2K40.39508733
116MST40.39359447
117PRKACA0.39144775
118NLK0.38537692
119PLK20.38400537
120KIT0.38316545
121CAMKK20.38303998
122TEC0.37550287
123RET0.37504974
124CAMK2A0.37442170
125TAF10.37186749
126AKT30.36743268
127BRD40.36715791
128SIK10.36355783
129STK390.36323161
130PRKCZ0.35950391
131DYRK30.35528059
132CHEK10.34968472
133PIK3CG0.34570463
134PLK10.33966959
135CDK40.33031595
136PAK60.32543281
137TTK0.32524237
138DYRK1A0.32414533
139IRAK10.31888491
140MAP2K60.30492248
141MAPK80.30166260
142PASK0.30161972
143GRK50.30028770
144TYK20.29515433
145CDK50.29314316
146MAP3K70.28848636
147GRK60.28675515
148PHKG10.28516974
149PHKG20.28516974
150STK100.28493449
151PAK40.27547327
152ATM0.26795938
153MAP3K130.26776475
154CDK90.26309004
155GSK3B0.26106724
156PINK10.25485825
157TAOK30.24951123
158CSF1R0.24654526
159CSNK1G20.24610815
160CSNK1D0.24248706
161ATR0.24238831
162ERN10.24038687
163TTN0.22511502
164EPHB10.22347161
165MAPK120.19962092
166PRKCG0.18278977
167GSK3A0.18209208
168SGK4940.17935384
169SGK2230.17935384

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.98142079
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.92359748
3Olfactory transduction_Homo sapiens_hsa047402.79361844
4Fatty acid biosynthesis_Homo sapiens_hsa000612.68251150
5Butanoate metabolism_Homo sapiens_hsa006502.67160060
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.35650579
7Linoleic acid metabolism_Homo sapiens_hsa005912.29936605
8Dorso-ventral axis formation_Homo sapiens_hsa043202.29458423
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.26954202
10Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.14476710
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.12175973
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.11093615
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.08245552
14Maturity onset diabetes of the young_Homo sapiens_hsa049502.07216977
15Glucagon signaling pathway_Homo sapiens_hsa049222.02577668
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.99420767
17Carbohydrate digestion and absorption_Homo sapiens_hsa049731.96646824
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.91634129
19Fanconi anemia pathway_Homo sapiens_hsa034601.81382054
20Pyruvate metabolism_Homo sapiens_hsa006201.70996017
21Tryptophan metabolism_Homo sapiens_hsa003801.67078594
22Basal transcription factors_Homo sapiens_hsa030221.64517602
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.59213280
24Amphetamine addiction_Homo sapiens_hsa050311.58437098
25Oxidative phosphorylation_Homo sapiens_hsa001901.57345564
26Ether lipid metabolism_Homo sapiens_hsa005651.55104951
27Homologous recombination_Homo sapiens_hsa034401.54581088
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.53813432
29Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.53371684
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.50707585
31Long-term potentiation_Homo sapiens_hsa047201.50312215
32PPAR signaling pathway_Homo sapiens_hsa033201.49091758
33Chemical carcinogenesis_Homo sapiens_hsa052041.46932144
34Estrogen signaling pathway_Homo sapiens_hsa049151.44320168
35Oocyte meiosis_Homo sapiens_hsa041141.43112648
36Protein export_Homo sapiens_hsa030601.42907690
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.41590835
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.41104988
39Circadian entrainment_Homo sapiens_hsa047131.38044789
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.37956613
41RNA polymerase_Homo sapiens_hsa030201.37365494
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.37126163
43Caffeine metabolism_Homo sapiens_hsa002321.35764921
44Selenocompound metabolism_Homo sapiens_hsa004501.34605760
45Propanoate metabolism_Homo sapiens_hsa006401.31845608
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.31456080
47Bile secretion_Homo sapiens_hsa049761.27359387
48Insulin secretion_Homo sapiens_hsa049111.22232083
49Parkinsons disease_Homo sapiens_hsa050121.19896355
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.19791008
51Vitamin B6 metabolism_Homo sapiens_hsa007501.18197074
52Peroxisome_Homo sapiens_hsa041461.17678408
53Synaptic vesicle cycle_Homo sapiens_hsa047211.17424325
54Nitrogen metabolism_Homo sapiens_hsa009101.16678040
55Aldosterone synthesis and secretion_Homo sapiens_hsa049251.15877783
56Type II diabetes mellitus_Homo sapiens_hsa049301.14213104
57Glycerolipid metabolism_Homo sapiens_hsa005611.13811908
58Thyroid hormone signaling pathway_Homo sapiens_hsa049191.13080832
59One carbon pool by folate_Homo sapiens_hsa006701.12183131
60RNA degradation_Homo sapiens_hsa030181.11694164
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.11094063
62Retinol metabolism_Homo sapiens_hsa008301.10319100
63Renin secretion_Homo sapiens_hsa049241.08052926
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.07723999
65Dopaminergic synapse_Homo sapiens_hsa047281.07120460
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.06805300
67Glycosaminoglycan degradation_Homo sapiens_hsa005311.03661740
68Regulation of autophagy_Homo sapiens_hsa041401.03110917
69Insulin resistance_Homo sapiens_hsa049311.02126763
70Inositol phosphate metabolism_Homo sapiens_hsa005621.01980778
71Glutamatergic synapse_Homo sapiens_hsa047241.01858366
72Glycerophospholipid metabolism_Homo sapiens_hsa005641.01378323
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.01365216
74Salivary secretion_Homo sapiens_hsa049701.00676403
75Fatty acid degradation_Homo sapiens_hsa000710.99911890
76B cell receptor signaling pathway_Homo sapiens_hsa046620.99581915
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99376422
78AMPK signaling pathway_Homo sapiens_hsa041520.99201880
79Gastric acid secretion_Homo sapiens_hsa049710.97318002
80beta-Alanine metabolism_Homo sapiens_hsa004100.97183506
81Huntingtons disease_Homo sapiens_hsa050160.97106061
82Cocaine addiction_Homo sapiens_hsa050300.96025688
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.94982899
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.93929188
85mTOR signaling pathway_Homo sapiens_hsa041500.93735045
86Lysine degradation_Homo sapiens_hsa003100.91533645
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.91136327
88cAMP signaling pathway_Homo sapiens_hsa040240.90727220
89Thyroid hormone synthesis_Homo sapiens_hsa049180.90091960
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.90068984
91Sulfur relay system_Homo sapiens_hsa041220.89000945
92Morphine addiction_Homo sapiens_hsa050320.87094459
93Arachidonic acid metabolism_Homo sapiens_hsa005900.86546817
94VEGF signaling pathway_Homo sapiens_hsa043700.86426883
95Calcium signaling pathway_Homo sapiens_hsa040200.85335745
96Fatty acid metabolism_Homo sapiens_hsa012120.85075980
97Taste transduction_Homo sapiens_hsa047420.84946658
98Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.83835448
99Purine metabolism_Homo sapiens_hsa002300.83242712
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.82548110
101Cardiac muscle contraction_Homo sapiens_hsa042600.81720716
102Cholinergic synapse_Homo sapiens_hsa047250.80572831
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78642814
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75194688
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74921634
106Serotonergic synapse_Homo sapiens_hsa047260.74049632
107Nicotine addiction_Homo sapiens_hsa050330.71683074
108Metabolic pathways_Homo sapiens_hsa011000.70818272
109Insulin signaling pathway_Homo sapiens_hsa049100.68903833
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.66116513
111Circadian rhythm_Homo sapiens_hsa047100.66089257
112Intestinal immune network for IgA production_Homo sapiens_hsa046720.66050591
113Oxytocin signaling pathway_Homo sapiens_hsa049210.65237119
114Collecting duct acid secretion_Homo sapiens_hsa049660.64788880
115Fat digestion and absorption_Homo sapiens_hsa049750.60757024
116T cell receptor signaling pathway_Homo sapiens_hsa046600.60593796
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60036408
118Pentose phosphate pathway_Homo sapiens_hsa000300.59812661
119Carbon metabolism_Homo sapiens_hsa012000.59300422
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59142741
121Cysteine and methionine metabolism_Homo sapiens_hsa002700.58954644
122Biosynthesis of amino acids_Homo sapiens_hsa012300.57280481
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56745084
124Endocytosis_Homo sapiens_hsa041440.56393096
125Endometrial cancer_Homo sapiens_hsa052130.56137846
126Alzheimers disease_Homo sapiens_hsa050100.56084906
127MAPK signaling pathway_Homo sapiens_hsa040100.55704934
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55679633
129Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55564728
130ErbB signaling pathway_Homo sapiens_hsa040120.55525295
131Primary bile acid biosynthesis_Homo sapiens_hsa001200.55463610
132Glioma_Homo sapiens_hsa052140.55389312
133Non-small cell lung cancer_Homo sapiens_hsa052230.54847776
134Non-homologous end-joining_Homo sapiens_hsa034500.54741677
135ABC transporters_Homo sapiens_hsa020100.54491076
136Type I diabetes mellitus_Homo sapiens_hsa049400.54246951
137Histidine metabolism_Homo sapiens_hsa003400.53494170
138GABAergic synapse_Homo sapiens_hsa047270.53478892
139Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52919560
140Arginine biosynthesis_Homo sapiens_hsa002200.52655260
141Hedgehog signaling pathway_Homo sapiens_hsa043400.52582278
142Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51739222
143Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51662219
144Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50701406
145Osteoclast differentiation_Homo sapiens_hsa043800.50222594
146Pyrimidine metabolism_Homo sapiens_hsa002400.49674388
147Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49624878
148Ovarian steroidogenesis_Homo sapiens_hsa049130.49126344
149Mineral absorption_Homo sapiens_hsa049780.47891202
150mRNA surveillance pathway_Homo sapiens_hsa030150.46692510
151Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46537576
152Pancreatic cancer_Homo sapiens_hsa052120.45930024
153alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45314366
154Fructose and mannose metabolism_Homo sapiens_hsa000510.44421451
155GnRH signaling pathway_Homo sapiens_hsa049120.43420529
156Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43226896
157Pancreatic secretion_Homo sapiens_hsa049720.42962257
158Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42414290
159Vascular smooth muscle contraction_Homo sapiens_hsa042700.41931888
160Sphingolipid metabolism_Homo sapiens_hsa006000.41747479
161Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38982483
162Primary immunodeficiency_Homo sapiens_hsa053400.37931087
163RNA transport_Homo sapiens_hsa030130.33056776
164Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32912434
165Steroid biosynthesis_Homo sapiens_hsa001000.32767644
166Glutathione metabolism_Homo sapiens_hsa004800.27493101
167Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.26795837

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