FER1L6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1diterpenoid biosynthetic process (GO:0016102)8.31163651
2intestinal absorption (GO:0050892)8.03393374
3cilium or flagellum-dependent cell motility (GO:0001539)7.54938428
4COPI coating of Golgi vesicle (GO:0048205)7.44894925
5Golgi transport vesicle coating (GO:0048200)7.44894925
6axonemal dynein complex assembly (GO:0070286)6.88081787
7intestinal cholesterol absorption (GO:0030299)6.87068467
8glandular epithelial cell differentiation (GO:0002067)6.37939287
9endocrine pancreas development (GO:0031018)5.92002227
10peptide hormone processing (GO:0016486)5.81089818
11UDP-N-acetylglucosamine metabolic process (GO:0006047)5.70444144
12maintenance of gastrointestinal epithelium (GO:0030277)5.69013766
13terpenoid biosynthetic process (GO:0016114)5.60633535
14intestinal epithelial cell development (GO:0060576)5.56042695
15motile cilium assembly (GO:0044458)5.49498343
16cilium movement (GO:0003341)5.26048595
173-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.81243210
18purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.81243210
19digestive system process (GO:0022600)4.73723800
20retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.65965906
21COPII vesicle coating (GO:0048208)4.63106502
22epithelial cilium movement (GO:0003351)4.46100101
23primary alcohol catabolic process (GO:0034310)4.44862094
24O-glycan processing (GO:0016266)4.41863556
25angiotensin maturation (GO:0002003)4.41625430
26ethanol oxidation (GO:0006069)4.35694827
27maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.34622863
28oligosaccharide biosynthetic process (GO:0009312)4.32805655
29digestion (GO:0007586)4.29399874
30epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.27684817
31bundle of His cell to Purkinje myocyte communication (GO:0086069)4.26835627
32epithelial structure maintenance (GO:0010669)4.25445484
33flavonoid metabolic process (GO:0009812)4.15877505
34cellular glucuronidation (GO:0052695)4.15599951
35protein maturation by protein folding (GO:0022417)4.07119133
36columnar/cuboidal epithelial cell development (GO:0002066)4.06863972
37ethanol metabolic process (GO:0006067)4.01816520
38response to hepatocyte growth factor (GO:0035728)4.00639227
39cellular response to hepatocyte growth factor stimulus (GO:0035729)4.00639227
40glucuronate metabolic process (GO:0019585)3.99168112
41uronic acid metabolic process (GO:0006063)3.99168112
42retinoic acid metabolic process (GO:0042573)3.96371700
43regulation of guanylate cyclase activity (GO:0031282)3.93566707
44sperm capacitation (GO:0048240)3.91654883
45lipoprotein transport (GO:0042953)3.91234063
46regulation of type B pancreatic cell apoptotic process (GO:2000674)3.85115899
47multicellular organism reproduction (GO:0032504)3.84044103
48regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.75504515
49protein retention in ER lumen (GO:0006621)3.74763288
50transcytosis (GO:0045056)3.72131915
51exocrine pancreas development (GO:0031017)3.71072827
52pyrimidine-containing compound transmembrane transport (GO:0072531)3.70859920
53sequestering of metal ion (GO:0051238)3.70133174
54type B pancreatic cell development (GO:0003323)3.69542274
55desmosome organization (GO:0002934)3.68673812
56retinol metabolic process (GO:0042572)3.67759545
57protein autoprocessing (GO:0016540)3.67366623
58signal peptide processing (GO:0006465)3.64659858
59activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.64579347
60insulin secretion (GO:0030073)3.62303024
61epoxygenase P450 pathway (GO:0019373)3.61779829
62negative regulation of glycoprotein biosynthetic process (GO:0010561)3.59655283
63cellular response to vitamin D (GO:0071305)3.56250193
64phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.55458015
65positive regulation of insulin secretion (GO:0032024)3.55255072
66nucleotide-sugar biosynthetic process (GO:0009226)3.50287853
67multicellular organismal water homeostasis (GO:0050891)3.50057202
68ER overload response (GO:0006983)3.46694230
69positive regulation of nuclease activity (GO:0032075)3.44040637
70vesicle coating (GO:0006901)3.42027217
71relaxation of cardiac muscle (GO:0055119)3.37675958
72sulfation (GO:0051923)3.35992734
73reproduction (GO:0000003)3.33279065
74progesterone metabolic process (GO:0042448)3.29683717
75positive regulation of guanylate cyclase activity (GO:0031284)3.28699208
76vitamin transmembrane transport (GO:0035461)3.28258179
77membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.27933526
78regulation of Golgi to plasma membrane protein transport (GO:0042996)3.27425112
79retinal metabolic process (GO:0042574)3.25407694
80nucleotide-sugar metabolic process (GO:0009225)3.25102446
81primary alcohol metabolic process (GO:0034308)3.24508640
82glandular epithelial cell development (GO:0002068)3.21794270
83excretion (GO:0007588)3.20903000
84regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.20536645
85hormone catabolic process (GO:0042447)3.19910073
86protein O-linked glycosylation (GO:0006493)3.19673052
87regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.17375411
88actin filament depolymerization (GO:0030042)3.16247478
89hypotonic response (GO:0006971)3.13727851
90regulation of nuclease activity (GO:0032069)3.11734913
91sphingomyelin metabolic process (GO:0006684)3.09519379
92regulation of insulin secretion (GO:0050796)3.09367094
93water homeostasis (GO:0030104)3.08898457
94one-carbon compound transport (GO:0019755)3.08153726
95regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.08085616
96endoplasmic reticulum unfolded protein response (GO:0030968)3.06089645
97regulation of acrosome reaction (GO:0060046)3.05677984
98thyroid hormone metabolic process (GO:0042403)3.00877318
99regulation of bile acid biosynthetic process (GO:0070857)2.97152553
100cellular response to unfolded protein (GO:0034620)2.96769633
101membrane repolarization during action potential (GO:0086011)2.94084383
102ER-nucleus signaling pathway (GO:0006984)2.93728151
103androgen metabolic process (GO:0008209)2.93297443
104hemidesmosome assembly (GO:0031581)2.92830545
105sperm motility (GO:0030317)2.92752092
106regulation of cholesterol homeostasis (GO:2000188)2.92719891
107thrombin receptor signaling pathway (GO:0070493)2.91931027
108sulfate transmembrane transport (GO:1902358)2.90437214
109potassium ion homeostasis (GO:0055075)2.88330622
110drug metabolic process (GO:0017144)2.87015341
111peptide transport (GO:0015833)2.85999536
112peptide hormone secretion (GO:0030072)2.84972968
113protein targeting to Golgi (GO:0000042)2.84800573
114sodium ion homeostasis (GO:0055078)2.83663361
115inner ear receptor cell development (GO:0060119)2.82529923
116cellular response to topologically incorrect protein (GO:0035967)2.82323924
117Golgi organization (GO:0007030)2.81984088
118peptidyl-asparagine modification (GO:0018196)2.81939944
119sulfate transport (GO:0008272)2.81810412
120protein N-linked glycosylation via asparagine (GO:0018279)2.81630444
121negative regulation of digestive system process (GO:0060457)2.81118433
122positive regulation of peptide hormone secretion (GO:0090277)2.81084605
123diol metabolic process (GO:0034311)2.80658119
124GDP-mannose metabolic process (GO:0019673)2.79867860
125bicarbonate transport (GO:0015701)2.79279157
126detection of calcium ion (GO:0005513)2.79200462
127peptide secretion (GO:0002790)2.78631817
128receptor recycling (GO:0001881)2.77783576
129lung secretory cell differentiation (GO:0061140)2.77310434
130regulation of peptide hormone secretion (GO:0090276)2.77257861
131sulfur compound transport (GO:0072348)2.77139852
132intra-Golgi vesicle-mediated transport (GO:0006891)2.76863345
133coenzyme catabolic process (GO:0009109)2.75547020
134cellular response to pH (GO:0071467)2.75060235
135drug transmembrane transport (GO:0006855)2.73661962
136negative regulation of glycogen biosynthetic process (GO:0045719)2.73423093
137peptide catabolic process (GO:0043171)2.72789538
138regulation of peptide secretion (GO:0002791)2.71010344
139exogenous drug catabolic process (GO:0042738)2.69658550
140fucose metabolic process (GO:0006004)2.69037295
141ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.68974039
142positive regulation of peptide secretion (GO:0002793)2.68675615
143cyclooxygenase pathway (GO:0019371)2.67829092
144columnar/cuboidal epithelial cell differentiation (GO:0002065)2.67721951
145renal absorption (GO:0070293)2.67699647
146positive regulation of glycolytic process (GO:0045821)2.67667897
147regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.66439101
148endocrine process (GO:0050886)2.66439101
149regulation of systemic arterial blood pressure by hormone (GO:0001990)2.66439101
150drug catabolic process (GO:0042737)2.65675426
151response to endoplasmic reticulum stress (GO:0034976)2.65438272
152calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.64831476
153axoneme assembly (GO:0035082)2.64173374
154protein N-linked glycosylation (GO:0006487)2.63945701
155bile acid and bile salt transport (GO:0015721)2.62970600
156citrulline biosynthetic process (GO:0019240)2.62124495
157phenol-containing compound catabolic process (GO:0019336)2.60979479
158renal filtration (GO:0097205)2.60747450
159glomerular filtration (GO:0003094)2.59023781
160gap junction assembly (GO:0016264)2.58714138
161regulation of hypersensitivity (GO:0002883)2.56158893
162negative regulation of actin filament depolymerization (GO:0030835)2.55549065
163fusion of sperm to egg plasma membrane (GO:0007342)2.54939626
164single fertilization (GO:0007338)2.54109820
165actin filament capping (GO:0051693)2.53122980
166regulation of systemic arterial blood pressure (GO:0003073)2.52771395
167negative regulation of keratinocyte proliferation (GO:0010839)2.52648310
168left/right axis specification (GO:0070986)2.52378854
169regulation of cGMP biosynthetic process (GO:0030826)2.50320922
170drug transport (GO:0015893)2.48700527
171spermatid development (GO:0007286)2.46332067
172bile acid metabolic process (GO:0008206)2.45045367
173antibacterial humoral response (GO:0019731)2.44235359
174renal system process involved in regulation of blood volume (GO:0001977)2.41702929
175antimicrobial humoral response (GO:0019730)2.40882895

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.37646608
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.11620698
3SOX2_27498859_Chip-Seq_STOMACH_Mouse3.61492061
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.30378483
5CDX2_20551321_ChIP-Seq_CACO-2_Human2.92246089
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.85366602
7GATA4_25053715_ChIP-Seq_YYC3_Human2.45032957
8SOX2_20726797_ChIP-Seq_SW620_Human2.44339083
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.37546371
10GATA1_22025678_ChIP-Seq_K562_Human2.30296738
11CDX2_19796622_ChIP-Seq_MESCs_Mouse2.27000507
12FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.25781938
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.15555053
14GATA6_25053715_ChIP-Seq_YYC3_Human2.12328358
15ESR1_20079471_ChIP-ChIP_T-47D_Human2.05233867
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.96975082
17ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.93697115
18ESR1_21235772_ChIP-Seq_MCF-7_Human1.92740666
19* AHR_22903824_ChIP-Seq_MCF-7_Human1.85625651
20ZNF217_24962896_ChIP-Seq_MCF-7_Human1.84842585
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.81816356
22BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.80786040
23LXR_22158963_ChIP-Seq_LIVER_Mouse1.75900045
24* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.72077037
25VDR_22108803_ChIP-Seq_LS180_Human1.71830416
26AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.68878629
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62791136
28FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.59854322
29FOXO3_23340844_ChIP-Seq_DLD1_Human1.57950035
30* ARNT_22903824_ChIP-Seq_MCF-7_Human1.52885894
31PPAR_26484153_Chip-Seq_NCI-H1993_Human1.48168175
32PPARA_22158963_ChIP-Seq_LIVER_Mouse1.48043412
33FOXA1_25552417_ChIP-Seq_VCAP_Human1.47822917
34RXR_22158963_ChIP-Seq_LIVER_Mouse1.47409886
35CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.47193332
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.44036415
37TP53_18474530_ChIP-ChIP_U2OS_Human1.43733370
38HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.40673464
39BCAT_22108803_ChIP-Seq_LS180_Human1.39923926
40TCF4_18268006_ChIP-ChIP_LS174T_Human1.36436797
41STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.35702152
42FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.34241313
43* RUNX1_27514584_Chip-Seq_MCF-7_Human1.33334803
44NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.32841650
45KLF5_25053715_ChIP-Seq_YYC3_Human1.32283597
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.31659824
47ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.30514334
48FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.28233040
49KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27867019
50NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24621551
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.22656098
52GATA2_21666600_ChIP-Seq_HMVEC_Human1.22453665
53FOXA2_19822575_ChIP-Seq_HepG2_Human1.21749288
54ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18082806
55* PIAS1_25552417_ChIP-Seq_VCAP_Human1.18047683
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17807512
57RARG_19884340_ChIP-ChIP_MEFs_Mouse1.17672298
58FOXM1_26456572_ChIP-Seq_MCF-7_Human1.15873625
59* GATA1_19941826_ChIP-Seq_K562_Human1.13402025
60TP53_16413492_ChIP-PET_HCT116_Human1.11884947
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07802648
62CBP_20019798_ChIP-Seq_JUKART_Human1.07802648
63KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07036181
64* GATA2_19941826_ChIP-Seq_K562_Human1.06497653
65ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.04966809
66ZNF274_21170338_ChIP-Seq_K562_Hela1.03895321
67CDX2_22108803_ChIP-Seq_LS180_Human1.03823872
68GATA3_24758297_ChIP-Seq_MCF-7_Human1.03789067
69* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03319766
70DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03123660
71CEBPB_22108803_ChIP-Seq_LS180_Human1.02824047
72RACK7_27058665_Chip-Seq_MCF-7_Human1.01159731
73* TP63_23658742_ChIP-Seq_EP156T_Human1.00211339
74VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00023102
75TP63_22573176_ChIP-Seq_HFKS_Human0.99884072
76EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99546923
77DROSHA_22980978_ChIP-Seq_HELA_Human0.97873825
78* SMAD4_21799915_ChIP-Seq_A2780_Human0.97306079
79CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96901180
80CREB1_26743006_Chip-Seq_LNCaP_Human0.96855297
81SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.94969724
82SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.94969724
83SALL4_18804426_ChIP-ChIP_XEN_Mouse0.94338407
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93981240
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93307045
86FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.93181681
87STAT3_23295773_ChIP-Seq_U87_Human0.93130526
88SMAD_19615063_ChIP-ChIP_OVARY_Human0.92893644
89Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.92694250
90AR_21909140_ChIP-Seq_LNCAP_Human0.92390363
91ATF3_27146783_Chip-Seq_COLON_Human0.91858962
92GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91428882
93ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91192176
94CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91012860
95SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90004562
96RXR_22108803_ChIP-Seq_LS180_Human0.89249594
97STAT1_20625510_ChIP-Seq_HELA_Human0.89149065
98NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89015325
99NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89015325
100* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87635310
101* HNF4A_19822575_ChIP-Seq_HepG2_Human0.87167074
102SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.86547712
103IRF8_22096565_ChIP-ChIP_GC-B_Human0.86069442
104SOX9_24532713_ChIP-Seq_HFSC_Mouse0.85849205
105PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.85695113
106PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.85554128
107CBP_21632823_ChIP-Seq_H3396_Human0.85323276
108ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.85280765
109ZNF263_19887448_ChIP-Seq_K562_Human0.84933695
110VDR_24787735_ChIP-Seq_THP-1_Human0.84587091
111MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.84423203
112SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.83918761
113TBL1_22424771_ChIP-Seq_293T_Human0.83212096
114EP300_21415370_ChIP-Seq_HL-1_Mouse0.83179009
115EGR1_19032775_ChIP-ChIP_M12_Human0.82473648
116GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.82390287
117PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.82132141
118* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78843577
119FOXA1_21572438_ChIP-Seq_LNCaP_Human0.77998201
120CTNNB1_20460455_ChIP-Seq_HCT116_Human0.76787527
121* CJUN_26792858_Chip-Seq_BT549_Human0.76437369
122SMAD3_21741376_ChIP-Seq_HESCs_Human0.75947504
123CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.73236578
124* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71835394
125FOXA1_25329375_ChIP-Seq_VCAP_Human0.71749939
126FOXA1_27270436_Chip-Seq_PROSTATE_Human0.71749939
127P63_26484246_Chip-Seq_KERATINOCYTES_Human0.71429716
128HTT_18923047_ChIP-ChIP_STHdh_Human0.70216460
129PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.69893664
130AR_20517297_ChIP-Seq_VCAP_Human0.69462982
131WT1_25993318_ChIP-Seq_PODOCYTE_Human0.69199055
132CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.67626617

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004264_abnormal_extraembryonic_tissu4.51513075
2MP0003283_abnormal_digestive_organ4.42432423
3MP0004043_abnormal_pH_regulation4.36139022
4MP0002877_abnormal_melanocyte_morpholog4.33589347
5MP0010234_abnormal_vibrissa_follicle4.09311608
6MP0001666_abnormal_nutrient_absorption3.83783443
7MP0003183_abnormal_peptide_metabolism3.26486159
8MP0008004_abnormal_stomach_pH3.19504947
9MP0003866_abnormal_defecation3.03185708
10MP0002693_abnormal_pancreas_physiology2.95740532
11MP0000462_abnormal_digestive_system2.92500460
12MP0009780_abnormal_chondrocyte_physiolo2.91421717
13MP0005360_urolithiasis2.83033031
14MP0000465_gastrointestinal_hemorrhage2.69767771
15MP0005410_abnormal_fertilization2.65617870
16MP0002909_abnormal_adrenal_gland2.64086093
17MP0001664_abnormal_digestion2.46416500
18MP0003252_abnormal_bile_duct2.44270034
19MP0001944_abnormal_pancreas_morphology2.40374383
20MP0003300_gastrointestinal_ulcer2.38863501
21MP0000678_abnormal_parathyroid_gland2.38501778
22MP0006054_spinal_hemorrhage2.25901579
23MP0003718_maternal_effect2.19859294
24MP0004782_abnormal_surfactant_physiolog2.09793902
25MP0005085_abnormal_gallbladder_physiolo2.05950247
26MP0003868_abnormal_feces_composition2.03966028
27MP0010386_abnormal_urinary_bladder1.93463428
28MP0005365_abnormal_bile_salt1.92857765
29MP0005381_digestive/alimentary_phenotyp1.89552436
30MP0005409_darkened_coat_color1.87710344
31MP0002837_dystrophic_cardiac_calcinosis1.87062388
32MP0005379_endocrine/exocrine_gland_phen1.82482682
33MP0005220_abnormal_exocrine_pancreas1.73337011
34MP0000013_abnormal_adipose_tissue1.71571891
35MP0001663_abnormal_digestive_system1.71479397
36MP0003195_calcinosis1.70323880
37MP0001765_abnormal_ion_homeostasis1.68980923
38MP0002078_abnormal_glucose_homeostasis1.64660209
39MP0006072_abnormal_retinal_apoptosis1.61610502
40MP0010678_abnormal_skin_adnexa1.60521783
41MP0000477_abnormal_intestine_morphology1.55585972
42MP0001873_stomach_inflammation1.55117030
43MP0000538_abnormal_urinary_bladder1.52861121
44MP0002876_abnormal_thyroid_physiology1.52240352
45MP0000470_abnormal_stomach_morphology1.52014312
46MP0000566_synostosis1.49814438
47MP0010155_abnormal_intestine_physiology1.43935019
48MP0009643_abnormal_urine_homeostasis1.41522225
49MP0002896_abnormal_bone_mineralization1.39356604
50MP0005166_decreased_susceptibility_to1.38052528
51MP0003329_amyloid_beta_deposits1.37973797
52MP0002234_abnormal_pharynx_morphology1.37070583
53MP0000383_abnormal_hair_follicle1.32943525
54MP0001986_abnormal_taste_sensitivity1.29916975
55MP0008875_abnormal_xenobiotic_pharmacok1.29089050
56MP0010368_abnormal_lymphatic_system1.28348100
57MP0005395_other_phenotype1.27956774
58MP0002139_abnormal_hepatobiliary_system1.26782555
59MP0005023_abnormal_wound_healing1.26637083
60MP0005310_abnormal_salivary_gland1.25311565
61MP0004147_increased_porphyrin_level1.23179719
62MP0009379_abnormal_foot_pigmentation1.23165068
63MP0001501_abnormal_sleep_pattern1.21026371
64MP0002136_abnormal_kidney_physiology1.19202092
65MP0005636_abnormal_mineral_homeostasis1.18746504
66MP0005164_abnormal_response_to1.18501416
67MP0000613_abnormal_salivary_gland1.18467672
68MP0000490_abnormal_crypts_of1.17930420
69MP0005167_abnormal_blood-brain_barrier1.16614458
70MP0003045_fibrosis1.15823639
71MP0002138_abnormal_hepatobiliary_system1.15522170
72MP0002098_abnormal_vibrissa_morphology1.13955558
73MP0008961_abnormal_basal_metabolism1.13730933
74MP0003953_abnormal_hormone_level1.11722547
75MP0000537_abnormal_urethra_morphology1.11082186
76MP0010329_abnormal_lipoprotein_level1.10575314
77MP0010352_gastrointestinal_tract_polyps1.07721317
78MP0005275_abnormal_skin_tensile1.06114041
79MP0000003_abnormal_adipose_tissue1.05079615
80MP0000467_abnormal_esophagus_morphology1.00868119
81MP0001485_abnormal_pinna_reflex0.98359519
82MP0005448_abnormal_energy_balance0.97983306
83MP0005501_abnormal_skin_physiology0.95009319
84MP0008789_abnormal_olfactory_epithelium0.95001093
85MP0002118_abnormal_lipid_homeostasis0.90168771
86MP0000604_amyloidosis0.90107605
87MP0003950_abnormal_plasma_membrane0.88733203
88MP0002822_catalepsy0.87058178
89MP0003705_abnormal_hypodermis_morpholog0.86389639
90MP0005083_abnormal_biliary_tract0.83176813
91MP0001849_ear_inflammation0.83034504
92MP0000627_abnormal_mammary_gland0.82838997
93MP0002132_abnormal_respiratory_system0.81648257
94MP0000579_abnormal_nail_morphology0.81518999
95MP0005332_abnormal_amino_acid0.80183545
96MP0003119_abnormal_digestive_system0.79047262
97MP0004270_analgesia0.79035602
98MP0004484_altered_response_of0.77114543
99MP0001764_abnormal_homeostasis0.76995917
100MP0002277_abnormal_respiratory_mucosa0.76583351
101MP0009840_abnormal_foam_cell0.76275016
102MP0004947_skin_inflammation0.75374175
103MP0002796_impaired_skin_barrier0.74977005
104MP0000762_abnormal_tongue_morphology0.74351723
105MP0005376_homeostasis/metabolism_phenot0.74165381
106MP0003806_abnormal_nucleotide_metabolis0.73623859
107MP0003091_abnormal_cell_migration0.72057123
108MP0001756_abnormal_urination0.71472146
109MP0005670_abnormal_white_adipose0.71218391
110MP0002009_preneoplasia0.70377847
111MP0005319_abnormal_enzyme/_coenzyme0.70350947
112MP0000230_abnormal_systemic_arterial0.70313055
113MP0003315_abnormal_perineum_morphology0.69332465
114MP0001929_abnormal_gametogenesis0.68494549
115MP0004272_abnormal_basement_membrane0.68324203
116MP0005595_abnormal_vascular_smooth0.68258904
117MP0004185_abnormal_adipocyte_glucose0.67834751
118MP0005257_abnormal_intraocular_pressure0.65906930
119MP0002168_other_aberrant_phenotype0.65636526
120MP0003191_abnormal_cellular_cholesterol0.63797922
121MP0002653_abnormal_ependyma_morphology0.63670800
122MP0000609_abnormal_liver_physiology0.63437748
123MP0003828_pulmonary_edema0.63259601
124MP0002160_abnormal_reproductive_system0.63050901
125MP0002928_abnormal_bile_duct0.62597767
126MP0005394_taste/olfaction_phenotype0.62463537
127MP0005499_abnormal_olfactory_system0.62463537
128MP0005375_adipose_tissue_phenotype0.62209924
129MP0009642_abnormal_blood_homeostasis0.62141583
130MP0005187_abnormal_penis_morphology0.62009322
131MP0005248_abnormal_Harderian_gland0.61051408
132MP0005408_hypopigmentation0.60930235
133MP0003698_abnormal_male_reproductive0.60220244
134MP0000249_abnormal_blood_vessel0.59989796
135MP0004019_abnormal_vitamin_homeostasis0.59941458
136MP0000681_abnormal_thyroid_gland0.59119631
137MP0003879_abnormal_hair_cell0.56489056
138MP0001216_abnormal_epidermal_layer0.56258159
139MP0002060_abnormal_skin_morphology0.53666960
140MP0005646_abnormal_pituitary_gland0.53335581
141MP0005165_increased_susceptibility_to0.53068804
142MP0005334_abnormal_fat_pad0.52004908
143MP0005076_abnormal_cell_differentiation0.50691370
144MP0005666_abnormal_adipose_tissue0.48092243
145MP0003453_abnormal_keratinocyte_physiol0.44764111

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.05148961
2Hyperinsulinemic hypoglycemia (HP:0000825)6.59006025
3Abnormal respiratory motile cilium physiology (HP:0012261)6.43230857
4Abnormal ciliary motility (HP:0012262)6.40940035
5Absent/shortened dynein arms (HP:0200106)6.20490669
6Dynein arm defect of respiratory motile cilia (HP:0012255)6.20490669
7Hypoglycemic seizures (HP:0002173)5.97304801
8Symptomatic seizures (HP:0011145)5.91133547
9Abnormal respiratory motile cilium morphology (HP:0005938)5.80433206
10Abnormal respiratory epithelium morphology (HP:0012253)5.80433206
11Rhinitis (HP:0012384)5.57043128
12Hypoglycemic coma (HP:0001325)5.45157320
13Chronic bronchitis (HP:0004469)5.39515766
14Elevated circulating parathyroid hormone (PTH) level (HP:0003165)5.30311708
15Insulin-resistant diabetes mellitus (HP:0000831)5.02660385
16Conjugated hyperbilirubinemia (HP:0002908)4.65628647
17Hyperactive renin-angiotensin system (HP:0000841)4.55199345
18Right ventricular cardiomyopathy (HP:0011663)4.49964310
19Hyperglycemia (HP:0003074)4.28502809
20Nasal polyposis (HP:0100582)4.23713995
21Ileus (HP:0002595)4.14919238
22Bronchiectasis (HP:0002110)4.14844494
23Abdominal distention (HP:0003270)3.97839273
24Abnormality of the nasal mucosa (HP:0000433)3.91841020
25Decreased circulating renin level (HP:0003351)3.89976684
26Ketoacidosis (HP:0001993)3.65664462
27Abnormality of renin-angiotensin system (HP:0000847)3.62876224
28Abnormality of chloride homeostasis (HP:0011422)3.62433170
29Hyperparathyroidism (HP:0000843)3.50560065
30Hypokalemia (HP:0002900)3.44655857
31Abnormality of monocarboxylic acid metabolism (HP:0010996)3.37985213
32Abnormal pancreas size (HP:0012094)3.33721730
33Abnormality of calcium-phosphate metabolism (HP:0100530)3.25838678
34Infertility (HP:0000789)3.23503404
35Abnormality of the pancreatic islet cells (HP:0006476)3.22683407
36Abnormality of endocrine pancreas physiology (HP:0012093)3.22683407
37Abnormal biliary tract morphology (HP:0012440)3.20466994
38Pancreatic islet-cell hyperplasia (HP:0004510)3.15978439
39Late onset (HP:0003584)3.15710137
40Mucopolysacchariduria (HP:0008155)3.13417269
41Urinary glycosaminoglycan excretion (HP:0003541)3.13417269
42Tubulointerstitial nephritis (HP:0001970)3.12408563
43Congenital sensorineural hearing impairment (HP:0008527)3.06082124
44Metabolic alkalosis (HP:0200114)3.03590158
45Insulin resistance (HP:0000855)3.00639505
46Abnormality of potassium homeostasis (HP:0011042)2.98068900
47Malnutrition (HP:0004395)2.97469889
48Mildly elevated creatine phosphokinase (HP:0008180)2.95457740
49Abnormality of polysaccharide metabolism (HP:0011012)2.95333991
50Abnormality of glycosaminoglycan metabolism (HP:0004371)2.95333991
51Abnormality of mucopolysaccharide metabolism (HP:0011020)2.95333991
52Male infertility (HP:0003251)2.89174610
53Abnormality of small intestinal villus morphology (HP:0011472)2.84558866
54Villous atrophy (HP:0011473)2.84558866
55Chronic diarrhea (HP:0002028)2.77325922
56Large for gestational age (HP:0001520)2.74611331
57Popliteal pterygium (HP:0009756)2.74328215
58Exocrine pancreatic insufficiency (HP:0001738)2.74300763
59Generalized aminoaciduria (HP:0002909)2.69710655
60Milia (HP:0001056)2.57278071
61Hyponatremia (HP:0002902)2.55465890
62Pigmentary retinal degeneration (HP:0001146)2.53993337
63Hyperkalemia (HP:0002153)2.52149177
64Abnormality of the intrinsic pathway (HP:0010989)2.51146795
65Bronchitis (HP:0012387)2.50803604
66Autoimmune thrombocytopenia (HP:0001973)2.49337484
67Bundle branch block (HP:0011710)2.48174287
68Pili torti (HP:0003777)2.47156807
69Biliary tract neoplasm (HP:0100574)2.46726644
70Syncope (HP:0001279)2.46477461
71Hyperphosphatemia (HP:0002905)2.45878503
72Cone-rod dystrophy (HP:0000548)2.45456571
73Progressive sensorineural hearing impairment (HP:0000408)2.42602363
74Osteomalacia (HP:0002749)2.35411119
75Hypoplasia of dental enamel (HP:0006297)2.35152964
76Fat malabsorption (HP:0002630)2.32954148
77Abnormality of glutamine family amino acid metabolism (HP:0010902)2.32226230
78Unilateral renal agenesis (HP:0000122)2.31784828
79Alkalosis (HP:0001948)2.30342519
80Palpitations (HP:0001962)2.29868020
81Atrophic scars (HP:0001075)2.28273499
82Dysostosis multiplex (HP:0000943)2.27392765
83Abnormality of the gastric mucosa (HP:0004295)2.25842268
84Gastrointestinal dysmotility (HP:0002579)2.25090176
85Progressive hearing impairment (HP:0001730)2.24994201
86Abnormality of proline metabolism (HP:0010907)2.24076576
87Hydroxyprolinuria (HP:0003080)2.24076576
88Intrahepatic cholestasis (HP:0001406)2.15587659
89Autoimmune hemolytic anemia (HP:0001890)2.13958041
90Lip pit (HP:0100267)2.13772978
91Flat acetabular roof (HP:0003180)2.13301159
92Ventricular fibrillation (HP:0001663)2.12831203
93Hypophosphatemic rickets (HP:0004912)2.11960571
94Flattened epiphyses (HP:0003071)2.11193522
95Hemorrhage of the eye (HP:0011885)2.08867222
96Goiter (HP:0000853)2.07878171
97Myoglobinuria (HP:0002913)2.07327971
98Hyperaldosteronism (HP:0000859)2.06809379
99Abnormality of purine metabolism (HP:0004352)2.06744909
100Abnormal tarsal ossification (HP:0008369)2.05902857
101Micronodular cirrhosis (HP:0001413)2.00178321
102Abnormality of vitamin B metabolism (HP:0004340)1.99592973
103Abnormality of the vitamin B12 metabolism (HP:0004341)1.98339911
104Adrenal overactivity (HP:0002717)1.98167900
105Abnormality of the distal phalanges of the toes (HP:0010182)1.96777550
106Hypotension (HP:0002615)1.96434517
107Chronic sinusitis (HP:0011109)1.96356528
108Acanthocytosis (HP:0001927)1.96219976
109Alopecia of scalp (HP:0002293)1.96026304
110Spinal cord compression (HP:0002176)1.93236562
111Hypophosphatemia (HP:0002148)1.91095864
112Focal segmental glomerulosclerosis (HP:0000097)1.90953401
113Long toe (HP:0010511)1.89744375
114Hypercortisolism (HP:0001578)1.89526421
115Abnormal hair laboratory examination (HP:0003328)1.89467921
116Myopathic facies (HP:0002058)1.87990929
117Skin nodule (HP:0200036)1.86349568
118Rectal prolapse (HP:0002035)1.85529566
119Prolonged QT interval (HP:0001657)1.84198890
120Widely patent fontanelles and sutures (HP:0004492)1.83528540
121Recurrent sinusitis (HP:0011108)1.83403382
122Pancreatitis (HP:0001733)1.82901177
123Abnormal protein glycosylation (HP:0012346)1.82667861
124Abnormal glycosylation (HP:0012345)1.82667861
125Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.82667861
126Abnormal protein N-linked glycosylation (HP:0012347)1.82667861
127Abnormality of vitamin metabolism (HP:0100508)1.81801729
128Ankyloglossia (HP:0010296)1.81378183
129Agitation (HP:0000713)1.80934868
130Increased circulating renin level (HP:0000848)1.80750343
131Protuberant abdomen (HP:0001538)1.79005717
132Chronic hepatic failure (HP:0100626)1.77687285
133Renal salt wasting (HP:0000127)1.77544003
134Dehydration (HP:0001944)1.77217837
135Oligomenorrhea (HP:0000876)1.76778259
136Abnormality of sodium homeostasis (HP:0010931)1.76415803
137Plantar hyperkeratosis (HP:0007556)1.75106921
138Thoracolumbar scoliosis (HP:0002944)1.74779448
139Rickets (HP:0002748)1.74543137
140Onycholysis (HP:0001806)1.74252535
141Ketosis (HP:0001946)1.73308394
142Neonatal short-limb short stature (HP:0008921)1.69600754
143Vascular calcification (HP:0004934)1.67924583
144Glomerulosclerosis (HP:0000096)1.67619058
145Abnormality of carpal bone ossification (HP:0006257)1.67396281
146Severe short stature (HP:0003510)1.66269691
147Cardiovascular calcification (HP:0011915)1.63182997
148Subcapsular cataract (HP:0000523)1.62932664
149Arterial tortuosity (HP:0005116)1.61911361
150Recurrent otitis media (HP:0000403)1.58162212
151Abnormality of macular pigmentation (HP:0008002)1.57011893
152Enlarged epiphyses (HP:0010580)1.53420646
153Palmoplantar hyperkeratosis (HP:0000972)1.52473794
154Thin bony cortex (HP:0002753)1.52399432
155Atelectasis (HP:0100750)1.51942041
156Short nail (HP:0001799)1.51323194
157Hypobetalipoproteinemia (HP:0003563)1.51080967
158Curly hair (HP:0002212)1.49394275
159Hyperuricemia (HP:0002149)1.45756769
160Increased purine levels (HP:0004368)1.45756769
161Abnormality of the distal phalanx of the thumb (HP:0009617)1.44937491

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR5.04596182
2MST44.92933386
3FRK4.69252960
4PASK3.83954118
5TAOK33.56536251
6STK393.17549286
7PINK13.08483085
8MST1R3.03315146
9MAP3K22.90264348
10ACVR1B2.85653625
11MAP2K22.58439073
12MAP3K12.43450472
13LMTK22.30404366
14MAPK152.14008117
15HIPK22.03811916
16PRKD31.91884303
17PTK61.83414230
18NUAK11.80127721
19EPHA21.79823414
20ERN11.79272250
21PIK3CA1.77190934
22PRKG21.75092392
23RIPK11.65160617
24MET1.60979231
25STK241.58622954
26TESK11.57039436
27STK381.54391923
28OXSR11.52237761
29CDC42BPA1.49194583
30ERBB41.43492968
31DMPK1.42416430
32ICK1.41818649
33IRAK31.39055794
34PTK21.38753369
35NEK61.33962530
36MAP3K121.31162250
37WNK41.30484604
38MAP3K91.30277648
39NME11.24945906
40AKT31.20869788
41MAP3K131.17698480
42FER1.11986228
43LATS11.07588413
44PDGFRA1.03739678
45MAP2K11.03222972
46SCYL21.03207648
47FLT31.02057060
48MARK31.01116129
49PIK3CG0.95219549
50ARAF0.94534459
51PRKAA10.94025502
52PAK30.90670272
53PRKCI0.88333892
54TRPM70.87116783
55PTK2B0.86671891
56MYLK0.84436117
57MAP3K30.83070160
58CDK90.81673486
59PRKAA20.80032579
60IRAK10.79276139
61MAP3K70.78442385
62BRSK20.76929629
63GRK10.75315357
64NTRK10.74149442
65PBK0.73092541
66EPHA30.68688234
67KSR20.64221456
68BMPR20.63904785
69STK100.62383845
70MELK0.60947954
71CAMKK20.60339444
72MAPK110.59913185
73PRKCE0.56293713
74ADRBK20.54993071
75CAMK2D0.54972811
76MOS0.53815670
77PDPK10.53232053
78STK38L0.52265543
79EPHB20.51725937
80CSK0.50758720
81GRK60.49049987
82EPHB10.48156772
83EIF2AK30.45807861
84TEC0.45495694
85PRKCH0.45390852
86JAK20.45106041
87STK30.44982549
88ERBB20.44666264
89DYRK1B0.44074650
90CSNK1A10.42419727
91ITK0.41778637
92PDGFRB0.40918513
93TAOK10.40845385
94MAP3K100.39432395
95RPS6KB10.39421492
96PRKACG0.39178143
97WNK10.38969068
98JAK10.38889652
99CDK120.38625430
100RPS6KA20.38621725
101SGK30.38579241
102ABL20.38215495
103TGFBR20.38125733
104PRKCQ0.37243794
105CHUK0.35929337
106PDK30.35657416
107PDK40.35657416
108MAPKAPK30.35594732
109MTOR0.35528583
110PRKD20.34965025
111SRC0.34858899
112PRKCA0.34004488
113NEK20.32935192
114RET0.31716799
115GSK3A0.31198147
116SIK10.30963550
117ERBB30.30722524
118ZAP700.30505401
119BMX0.30433954
120TLK10.30038713
121TRIB30.29918374
122OBSCN0.29705423
123RPS6KA50.29006202
124PDK20.28880685
125TIE10.28565055
126PRKD10.28401119
127LIMK10.27876360
128WNK30.27797269
129MAP2K60.27665650
130PDK10.27116568
131ADRBK10.25859285
132MUSK0.25805288
133FGFR30.24505675
134AKT20.23889599
135BMPR1B0.23725718
136CAMK1D0.23642727
137PRKG10.23530211
138NTRK30.22791856
139IRAK20.22152123
140IGF1R0.22061828
141DDR20.21329857
142UHMK10.20466182
143ROCK10.20339940

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.96667394
2Sulfur metabolism_Homo sapiens_hsa009205.23540192
3Fat digestion and absorption_Homo sapiens_hsa049752.87345431
4Chemical carcinogenesis_Homo sapiens_hsa052042.79784740
5Mineral absorption_Homo sapiens_hsa049782.79631939
6Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.63546222
7Retinol metabolism_Homo sapiens_hsa008302.52642283
8Cyanoamino acid metabolism_Homo sapiens_hsa004602.50736604
9Protein export_Homo sapiens_hsa030602.38808806
10Insulin secretion_Homo sapiens_hsa049112.36524979
11Steroid hormone biosynthesis_Homo sapiens_hsa001402.34287932
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.25309276
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.13817148
14Arginine biosynthesis_Homo sapiens_hsa002202.07614803
15Vitamin digestion and absorption_Homo sapiens_hsa049771.96542520
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.89703933
17Galactose metabolism_Homo sapiens_hsa000521.76930131
18Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.76833013
19Nitrogen metabolism_Homo sapiens_hsa009101.71735778
20Type II diabetes mellitus_Homo sapiens_hsa049301.68650937
21Pancreatic secretion_Homo sapiens_hsa049721.66639090
22Renin-angiotensin system_Homo sapiens_hsa046141.64673086
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.57863402
24Protein digestion and absorption_Homo sapiens_hsa049741.51888014
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.51375754
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.49309006
27Starch and sucrose metabolism_Homo sapiens_hsa005001.46424367
28Vibrio cholerae infection_Homo sapiens_hsa051101.45824763
29Bile secretion_Homo sapiens_hsa049761.42375835
30ABC transporters_Homo sapiens_hsa020101.37372720
31Selenocompound metabolism_Homo sapiens_hsa004501.30501129
32Thyroid hormone synthesis_Homo sapiens_hsa049181.29719645
33Sphingolipid metabolism_Homo sapiens_hsa006001.29595041
34Cocaine addiction_Homo sapiens_hsa050301.21800909
35Histidine metabolism_Homo sapiens_hsa003401.18796243
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.16186076
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.10576531
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09958896
39Folate biosynthesis_Homo sapiens_hsa007901.06751520
40Tryptophan metabolism_Homo sapiens_hsa003801.06555568
41Circadian rhythm_Homo sapiens_hsa047101.02317784
42Fructose and mannose metabolism_Homo sapiens_hsa000511.01369201
43Linoleic acid metabolism_Homo sapiens_hsa005911.00314555
44beta-Alanine metabolism_Homo sapiens_hsa004101.00113795
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96304797
46Asthma_Homo sapiens_hsa053100.96103079
47Arginine and proline metabolism_Homo sapiens_hsa003300.94813083
48Fatty acid degradation_Homo sapiens_hsa000710.93744705
49Gastric acid secretion_Homo sapiens_hsa049710.93139459
50N-Glycan biosynthesis_Homo sapiens_hsa005100.93088456
51Insulin resistance_Homo sapiens_hsa049310.92430111
52Type I diabetes mellitus_Homo sapiens_hsa049400.90712168
53Dorso-ventral axis formation_Homo sapiens_hsa043200.90330088
54Intestinal immune network for IgA production_Homo sapiens_hsa046720.89287132
55Other glycan degradation_Homo sapiens_hsa005110.88184286
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85022029
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82059745
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76458783
59Amphetamine addiction_Homo sapiens_hsa050310.72350913
60Butanoate metabolism_Homo sapiens_hsa006500.70367644
61Glucagon signaling pathway_Homo sapiens_hsa049220.69521895
62Gap junction_Homo sapiens_hsa045400.68670891
63Fatty acid biosynthesis_Homo sapiens_hsa000610.67139221
64Renin secretion_Homo sapiens_hsa049240.66496663
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66435104
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63976859
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.63955788
68Allograft rejection_Homo sapiens_hsa053300.62956305
69Autoimmune thyroid disease_Homo sapiens_hsa053200.61905283
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.61607603
71Lysosome_Homo sapiens_hsa041420.59074858
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59067794
73Adherens junction_Homo sapiens_hsa045200.56570120
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56430156
75ECM-receptor interaction_Homo sapiens_hsa045120.55393346
76Peroxisome_Homo sapiens_hsa041460.55014426
77Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53418011
78Collecting duct acid secretion_Homo sapiens_hsa049660.53268741
79Bladder cancer_Homo sapiens_hsa052190.53008861
80Glycerolipid metabolism_Homo sapiens_hsa005610.51513566
81Tight junction_Homo sapiens_hsa045300.50599885
82Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46206127
83Graft-versus-host disease_Homo sapiens_hsa053320.46065129
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45682315
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.45680594
86Phenylalanine metabolism_Homo sapiens_hsa003600.45605147
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44602672
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42349311
89Prolactin signaling pathway_Homo sapiens_hsa049170.41578809
90Cholinergic synapse_Homo sapiens_hsa047250.40952786
91Estrogen signaling pathway_Homo sapiens_hsa049150.39210418
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39046181
93Taste transduction_Homo sapiens_hsa047420.38881118
94Inositol phosphate metabolism_Homo sapiens_hsa005620.38840248
95Olfactory transduction_Homo sapiens_hsa047400.38798378
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38362885
97GnRH signaling pathway_Homo sapiens_hsa049120.37556351
98Caffeine metabolism_Homo sapiens_hsa002320.35414654
99Ether lipid metabolism_Homo sapiens_hsa005650.34101294
100Tyrosine metabolism_Homo sapiens_hsa003500.31416913
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30059273
102Thyroid cancer_Homo sapiens_hsa052160.29965323
103Insulin signaling pathway_Homo sapiens_hsa049100.27664123
104Glutathione metabolism_Homo sapiens_hsa004800.27430295
105AMPK signaling pathway_Homo sapiens_hsa041520.27131202
106Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.25733370
107Fatty acid metabolism_Homo sapiens_hsa012120.25063249
108Salivary secretion_Homo sapiens_hsa049700.25036925
109Choline metabolism in cancer_Homo sapiens_hsa052310.24151184
110Arachidonic acid metabolism_Homo sapiens_hsa005900.24003995
111Ovarian steroidogenesis_Homo sapiens_hsa049130.22785743
112PPAR signaling pathway_Homo sapiens_hsa033200.22401328
113Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21660138
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.21277629
115Amoebiasis_Homo sapiens_hsa051460.20921268
116Serotonergic synapse_Homo sapiens_hsa047260.19989552
117Dopaminergic synapse_Homo sapiens_hsa047280.19586507
118Metabolic pathways_Homo sapiens_hsa011000.19343714
119Long-term potentiation_Homo sapiens_hsa047200.18624571
120Primary bile acid biosynthesis_Homo sapiens_hsa001200.18561318
121Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.17574061
122Propanoate metabolism_Homo sapiens_hsa006400.16166425
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.15961752
124Apoptosis_Homo sapiens_hsa042100.15338603
125Viral myocarditis_Homo sapiens_hsa054160.15221713
126Systemic lupus erythematosus_Homo sapiens_hsa053220.15028511
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.14718988
128Lysine degradation_Homo sapiens_hsa003100.14540331
129Focal adhesion_Homo sapiens_hsa045100.14290277
130Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.14150819
131Leukocyte transendothelial migration_Homo sapiens_hsa046700.13705816
132Melanogenesis_Homo sapiens_hsa049160.13646696
133Staphylococcus aureus infection_Homo sapiens_hsa051500.12160076
134Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.11192154
135Phagosome_Homo sapiens_hsa041450.11048207
136Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.10779563

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