FERD3L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerular filtration (GO:0003094)9.43912062
2lung epithelium development (GO:0060428)9.32571963
3axon extension involved in axon guidance (GO:0048846)8.59465627
4neuron projection extension involved in neuron projection guidance (GO:1902284)8.59465627
5renal filtration (GO:0097205)8.30807839
6glomerular basement membrane development (GO:0032836)7.70314431
7negative regulation of axon guidance (GO:1902668)7.21560813
8negative regulation of immunoglobulin mediated immune response (GO:0002890)7.15864564
9negative regulation of B cell mediated immunity (GO:0002713)7.15864564
10retinal ganglion cell axon guidance (GO:0031290)6.74072391
11positive regulation of tolerance induction (GO:0002645)6.41806062
12chondrocyte development (GO:0002063)6.36406771
13establishment of planar polarity (GO:0001736)6.00536884
14establishment of tissue polarity (GO:0007164)6.00536884
15regulation of chemokine-mediated signaling pathway (GO:0070099)5.97715973
16glomerular epithelial cell development (GO:0072310)5.91515753
17dendritic spine morphogenesis (GO:0060997)5.88629449
18positive regulation of oligodendrocyte differentiation (GO:0048714)5.81107677
19regulation of mesenchymal cell apoptotic process (GO:2001053)5.73985966
20cell proliferation involved in metanephros development (GO:0072203)5.71060628
21negative regulation of T cell differentiation in thymus (GO:0033085)5.65707760
22negative regulation of humoral immune response (GO:0002921)5.60927179
23G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071995.58590890
24regulation of tolerance induction (GO:0002643)5.53136606
25negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)5.52659335
26response to pheromone (GO:0019236)5.51800407
27tolerance induction (GO:0002507)5.45300144
28establishment of apical/basal cell polarity (GO:0035089)5.42196718
29establishment of monopolar cell polarity (GO:0061162)5.40685908
30establishment or maintenance of monopolar cell polarity (GO:0061339)5.40685908
31midbrain development (GO:0030901)5.37511279
32negative regulation of mesenchymal cell apoptotic process (GO:2001054)5.31780762
33negative chemotaxis (GO:0050919)5.24784543
34dopaminergic neuron differentiation (GO:0071542)5.14881893
35establishment of nucleus localization (GO:0040023)5.08603170
36lung lobe morphogenesis (GO:0060463)4.94197771
37positive regulation of BMP signaling pathway (GO:0030513)4.85808895
38negative regulation of axon extension involved in axon guidance (GO:0048843)4.80234270
39innervation (GO:0060384)4.69117226
40regulation of axon guidance (GO:1902667)4.67891760
41regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.64820833
42neuron fate determination (GO:0048664)4.60464765
43limb bud formation (GO:0060174)4.56924006
44embryonic foregut morphogenesis (GO:0048617)4.48544938
45axonal fasciculation (GO:0007413)4.47302004
46negative regulation of axon extension (GO:0030517)4.45645169
47neuronal action potential propagation (GO:0019227)4.41613086
48astrocyte differentiation (GO:0048708)4.38531731
49epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.35315950
50negative regulation of embryonic development (GO:0045992)4.30791119
51regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)4.25108277
52negative regulation of leukocyte chemotaxis (GO:0002689)4.21633700
53negative regulation of smooth muscle cell differentiation (GO:0051151)4.13673076
54branching involved in salivary gland morphogenesis (GO:0060445)4.11997367
55left/right pattern formation (GO:0060972)4.08877143
56mesenchymal cell proliferation (GO:0010463)4.04560097
57artery development (GO:0060840)4.03550381
58dorsal/ventral neural tube patterning (GO:0021904)3.98124154
59negative regulation of DNA-templated transcription, elongation (GO:0032785)3.95546950
60negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.95546950
61lateral sprouting from an epithelium (GO:0060601)3.88883983
62cell proliferation involved in kidney development (GO:0072111)3.80247757
63regulation of germinal center formation (GO:0002634)3.78558517
64CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.74642942
65heparan sulfate proteoglycan metabolic process (GO:0030201)3.72509006
66regulation of organ formation (GO:0003156)3.71287353
67urogenital system development (GO:0001655)3.70252753
68positive regulation of gastrulation (GO:2000543)3.69232801
69cranial nerve morphogenesis (GO:0021602)3.61254364
70embryonic skeletal system development (GO:0048706)3.53835987
71somite development (GO:0061053)3.50761666
72retina layer formation (GO:0010842)3.42003786
73regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.39752012
74lung-associated mesenchyme development (GO:0060484)3.38348308
75histamine secretion (GO:0001821)3.37811878
76regulation of oligodendrocyte differentiation (GO:0048713)3.35082639
77regulation of T cell differentiation in thymus (GO:0033081)3.21853898
78positive regulation of embryonic development (GO:0040019)3.20565654
79negative regulation of alpha-beta T cell differentiation (GO:0046639)3.20285290
80negative regulation of T cell differentiation (GO:0045581)3.15927117
81negative regulation of axonogenesis (GO:0050771)3.14791429
82osteoblast development (GO:0002076)3.14560450
83regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)3.13529200
84prostate gland growth (GO:0060736)3.13303956
85neuroblast proliferation (GO:0007405)3.09974725
86epithelial cell differentiation involved in prostate gland development (GO:0060742)3.08397573
87camera-type eye morphogenesis (GO:0048593)3.08136295
88neuronal stem cell maintenance (GO:0097150)3.05104022
89eye photoreceptor cell differentiation (GO:0001754)3.03978956
90photoreceptor cell differentiation (GO:0046530)3.03978956
91regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.00984362
92peptidyl-arginine omega-N-methylation (GO:0035247)3.00909214
93myotube differentiation (GO:0014902)3.00775522
94negative regulation of cytosolic calcium ion concentration (GO:0051481)2.99750639
95negative regulation of chemotaxis (GO:0050922)2.97005163
96thalamus development (GO:0021794)2.96678804
97neuron recognition (GO:0008038)2.94454950
98face development (GO:0060324)2.90374651
99regulation of axon extension involved in axon guidance (GO:0048841)2.89273293
100planar cell polarity pathway involved in neural tube closure (GO:0090179)2.88572917

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.69037625
2E2F7_22180533_ChIP-Seq_HELA_Human3.86259343
3EED_16625203_ChIP-ChIP_MESCs_Mouse3.64676612
4PHC1_16625203_ChIP-ChIP_MESCs_Mouse3.50201346
5EZH2_27304074_Chip-Seq_ESCs_Mouse3.34246050
6CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.13796590
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.13022811
8TP63_19390658_ChIP-ChIP_HaCaT_Human2.95506967
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.93873089
10RNF2_27304074_Chip-Seq_ESCs_Mouse2.87732897
11GBX2_23144817_ChIP-Seq_PC3_Human2.81201045
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.74981115
13RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.74704966
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.70818263
15TAF15_26573619_Chip-Seq_HEK293_Human2.69471709
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.69205126
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.66367752
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.66367752
19ERG_21242973_ChIP-ChIP_JURKAT_Human2.59554522
20CBX2_27304074_Chip-Seq_ESCs_Mouse2.55635451
21TRIM28_21343339_ChIP-Seq_HEK293_Human2.52338841
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.49292866
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.36365680
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.32861843
25EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.31442502
26SUZ12_27294783_Chip-Seq_ESCs_Mouse2.28447768
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.24985789
28PIAS1_25552417_ChIP-Seq_VCAP_Human2.13765472
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.08146984
30ZNF274_21170338_ChIP-Seq_K562_Hela2.06602175
31EZH2_27294783_Chip-Seq_ESCs_Mouse2.04470644
32RBPJ_22232070_ChIP-Seq_NCS_Mouse2.02540942
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.93994768
34TP53_20018659_ChIP-ChIP_R1E_Mouse1.86960885
35DROSHA_22980978_ChIP-Seq_HELA_Human1.84742463
36* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80279708
37* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.70511930
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.68982476
39CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.67423406
40OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.62377204
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61518017
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60867630
43ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.58938695
44* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.54581871
45RING1B_27294783_Chip-Seq_ESCs_Mouse1.52799321
46* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.52046778
47P300_19829295_ChIP-Seq_ESCs_Human1.51020212
48AR_21572438_ChIP-Seq_LNCaP_Human1.50110589
49NR3C1_23031785_ChIP-Seq_PC12_Mouse1.49209137
50SOX2_18555785_ChIP-Seq_MESCs_Mouse1.46385164
51KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.42821577
52YAP1_20516196_ChIP-Seq_MESCs_Mouse1.37686031
53RING1B_27294783_Chip-Seq_NPCs_Mouse1.33373543
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31793217
55SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.31705618
56SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.29080728
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.23650165
58* SOX2_16153702_ChIP-ChIP_HESCs_Human1.22175868
59ISL1_27105846_Chip-Seq_CPCs_Mouse1.19694445
60KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.18547925
61AHR_22903824_ChIP-Seq_MCF-7_Human1.18178278
62ARNT_22903824_ChIP-Seq_MCF-7_Human1.12062838
63GATA1_26923725_Chip-Seq_HPCs_Mouse1.10582786
64CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09657440
65TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09283788
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09230511
67REST_18959480_ChIP-ChIP_MESCs_Mouse1.08587323
68* REST_21632747_ChIP-Seq_MESCs_Mouse1.07947643
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07110193
70EWS_26573619_Chip-Seq_HEK293_Human1.05898471
71HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.05815946
72CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04401266
73HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.02807282
74TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01004270
75TBX3_20139965_ChIP-Seq_ESCs_Mouse1.00539939
76ZFP281_18757296_ChIP-ChIP_E14_Mouse0.98747824
77SOX9_26525672_Chip-Seq_HEART_Mouse0.98027812
78NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97169871
79NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97071662
80* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92396861
81CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89240881
82ZFP281_27345836_Chip-Seq_ESCs_Mouse0.88989606
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88859399
84SOX3_22085726_ChIP-Seq_NPCs_Mouse0.88650453
85SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.85816808
86POU5F1_16518401_ChIP-PET_MESCs_Mouse0.85602271
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85398486
88CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.84343992
89CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.84159010
90RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.83896594
91CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.83543397
92* RNF2_27304074_Chip-Seq_NSC_Mouse0.83256037
93* AR_19668381_ChIP-Seq_PC3_Human0.83007306
94SMAD4_21799915_ChIP-Seq_A2780_Human0.82093892
95OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81161048
96ETV2_25802403_ChIP-Seq_MESCs_Mouse0.80108641
97POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.79817525
98TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.79351756
99* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.78841661
100TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.77534958

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ6.37407435
2MP0002102_abnormal_ear_morphology4.68354887
3MP0000537_abnormal_urethra_morphology4.36229283
4MP0003122_maternal_imprinting4.22294348
5MP0002234_abnormal_pharynx_morphology3.59129019
6MP0009053_abnormal_anal_canal3.48150447
7MP0000467_abnormal_esophagus_morphology3.37025000
8MP0004133_heterotaxia3.31481311
9MP0001529_abnormal_vocalization3.20400825
10MP0002282_abnormal_trachea_morphology2.86490966
11MP0000566_synostosis2.84412752
12MP0000569_abnormal_digit_pigmentation2.69390625
13MP0002751_abnormal_autonomic_nervous2.65257221
14MP0003942_abnormal_urinary_system2.65050757
15MP0000778_abnormal_nervous_system2.53115458
16MP0003315_abnormal_perineum_morphology2.36180694
17MP0005076_abnormal_cell_differentiation2.29594432
18MP0001293_anophthalmia2.27382740
19MP0002653_abnormal_ependyma_morphology2.14557132
20MP0002249_abnormal_larynx_morphology2.03751352
21MP0000462_abnormal_digestive_system2.02131211
22MP0003121_genomic_imprinting2.00862125
23MP0003938_abnormal_ear_development1.96058091
24MP0009379_abnormal_foot_pigmentation1.80444422
25MP0004742_abnormal_vestibular_system1.80250532
26MP0010030_abnormal_orbit_morphology1.67254022
27MP0005381_digestive/alimentary_phenotyp1.65560167
28MP0003880_abnormal_central_pattern1.60977638
29MP0008057_abnormal_DNA_replication1.57945880
30MP0002837_dystrophic_cardiac_calcinosis1.56811906
31MP0002092_abnormal_eye_morphology1.51784910
32MP0002932_abnormal_joint_morphology1.50209329
33MP0000534_abnormal_ureter_morphology1.47279894
34MP0000383_abnormal_hair_follicle1.44354167
35MP0000026_abnormal_inner_ear1.44258815
36MP0003115_abnormal_respiratory_system1.37271722
37MP0000049_abnormal_middle_ear1.34221212
38MP0002938_white_spotting1.32757210
39MP0001663_abnormal_digestive_system1.32654633
40MP0003937_abnormal_limbs/digits/tail_de1.30134456
41MP0000955_abnormal_spinal_cord1.27809240
42MP0000631_abnormal_neuroendocrine_gland1.20653158
43* MP0003861_abnormal_nervous_system1.15931406
44MP0008932_abnormal_embryonic_tissue1.09403830
45MP0004084_abnormal_cardiac_muscle1.03127432
46MP0001188_hyperpigmentation1.02929752
47MP0002116_abnormal_craniofacial_bone1.01806012
48MP0004859_abnormal_synaptic_plasticity1.00310694
49MP0002184_abnormal_innervation0.99143444
50MP0002697_abnormal_eye_size0.97144088
51MP0003119_abnormal_digestive_system0.96105009
52MP0006292_abnormal_olfactory_placode0.94582100
53MP0008961_abnormal_basal_metabolism0.92651464
54MP0002152_abnormal_brain_morphology0.92071189
55MP0005391_vision/eye_phenotype0.90351474
56MP0002233_abnormal_nose_morphology0.90144543
57MP0005171_absent_coat_pigmentation0.88351246
58MP0005508_abnormal_skeleton_morphology0.87895975
59MP0002111_abnormal_tail_morphology0.86655439
60MP0009780_abnormal_chondrocyte_physiolo0.85071107
61MP0001286_abnormal_eye_development0.81830728
62MP0001324_abnormal_eye_pigmentation0.81704722
63MP0001299_abnormal_eye_distance/0.80860051
64MP0003634_abnormal_glial_cell0.80623424
65MP0004233_abnormal_muscle_weight0.80052946
66MP0003635_abnormal_synaptic_transmissio0.78576761
67MP0002098_abnormal_vibrissa_morphology0.77640492
68* MP0002882_abnormal_neuron_morphology0.77605239
69MP0002064_seizures0.77553572
70MP0002084_abnormal_developmental_patter0.76856382
71MP0003755_abnormal_palate_morphology0.76066293
72MP0001943_abnormal_respiration0.75030328
73MP0002752_abnormal_somatic_nervous0.70941339
74MP0000428_abnormal_craniofacial_morphol0.70733773
75MP0010678_abnormal_skin_adnexa0.70334850
76MP0000163_abnormal_cartilage_morphology0.70214131
77MP0001905_abnormal_dopamine_level0.69625885
78MP0004197_abnormal_fetal_growth/weight/0.69019154
79MP0004924_abnormal_behavior0.68851577
80MP0005386_behavior/neurological_phenoty0.68851577
81MP0004142_abnormal_muscle_tone0.68264725
82MP0000749_muscle_degeneration0.68145003
83MP0002063_abnormal_learning/memory/cond0.68046034
84MP0004272_abnormal_basement_membrane0.67796585
85* MP0002085_abnormal_embryonic_tissue0.66580639
86MP0003890_abnormal_embryonic-extraembry0.64733888
87MP0006054_spinal_hemorrhage0.64124861
88MP0005646_abnormal_pituitary_gland0.61537486
89MP0002081_perinatal_lethality0.60540019
90MP0008058_abnormal_DNA_repair0.59904053
91MP0005220_abnormal_exocrine_pancreas0.59897076
92MP0001346_abnormal_lacrimal_gland0.59232348
93MP0000350_abnormal_cell_proliferation0.58601589
94MP0004811_abnormal_neuron_physiology0.56955342
95MP0002557_abnormal_social/conspecific_i0.56371715
96MP0003950_abnormal_plasma_membrane0.55345920
97MP0003137_abnormal_impulse_conducting0.54717281
98MP0005248_abnormal_Harderian_gland0.53904354
99MP0000613_abnormal_salivary_gland0.53022155
100MP0002168_other_aberrant_phenotype0.52715389

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.04934308
2Maternal diabetes (HP:0009800)5.62012992
3Abnormal number of incisors (HP:0011064)4.91012332
4Aplasia/Hypoplasia of the uvula (HP:0010293)4.71523845
5Anophthalmia (HP:0000528)4.44796946
6Synostosis of carpal bones (HP:0005048)4.42010710
7Diaphragmatic weakness (HP:0009113)3.95693104
8Carpal synostosis (HP:0009702)3.92613622
9Growth hormone deficiency (HP:0000824)3.65242449
10Limb dystonia (HP:0002451)3.64888331
11Tented upper lip vermilion (HP:0010804)3.52918978
12Septo-optic dysplasia (HP:0100842)3.43036389
13Abnormality of the labia minora (HP:0012880)3.28039362
14Synostosis involving bones of the hand (HP:0004278)3.20746218
15Prenatal maternal abnormality (HP:0002686)3.20075039
16Aplasia cutis congenita (HP:0001057)3.11967048
17Bifid tongue (HP:0010297)3.10341947
18Tarsal synostosis (HP:0008368)3.10062752
19Narrow nasal bridge (HP:0000446)3.05190079
20Anosmia (HP:0000458)2.99518870
21Ulnar deviation of finger (HP:0009465)2.96737498
22Abnormality of the upper arm (HP:0001454)2.94131971
23Synostosis involving bones of the feet (HP:0009140)2.84983139
24Synostosis involving bones of the lower limbs (HP:0009138)2.84983139
25Cheekbone underdevelopment (HP:0010669)2.81883979
26Small epiphyses (HP:0010585)2.74230243
27Carpal bone hypoplasia (HP:0001498)2.69331336
28Wide cranial sutures (HP:0010537)2.68764101
29Widely patent fontanelles and sutures (HP:0004492)2.68589465
30Broad distal phalanx of finger (HP:0009836)2.67519770
31Concave nail (HP:0001598)2.65819818
32Triphalangeal thumb (HP:0001199)2.65579741
33Abnormality of the humerus (HP:0003063)2.63524924
34Abnormality of the parathyroid morphology (HP:0011766)2.58873378
35Mesangial abnormality (HP:0001966)2.57836823
36Irregular vertebral endplates (HP:0003301)2.57277716
37True hermaphroditism (HP:0010459)2.45253354
38Abnormality of chromosome segregation (HP:0002916)2.43220849
39Labial hypoplasia (HP:0000066)2.40301682
40Abnormality of the incisor (HP:0000676)2.38043281
41Absent septum pellucidum (HP:0001331)2.37944522
42Porencephaly (HP:0002132)2.36008480
43Short nail (HP:0001799)2.35736663
44Intestinal atresia (HP:0011100)2.31411977
45Aqueductal stenosis (HP:0002410)2.30402466
46Morphological abnormality of the middle ear (HP:0008609)2.30317685
4711 pairs of ribs (HP:0000878)2.30047482
48Hypokinesia (HP:0002375)2.29026910
49Oligodactyly (hands) (HP:0001180)2.27772410
50Ulnar deviation of the hand or of fingers of the hand (HP:0001193)2.26709682
51Neurofibrillary tangles (HP:0002185)2.22443157
52Hypoplastic female external genitalia (HP:0012815)2.21867248
53Specific learning disability (HP:0001328)2.21271488
54Cerebral inclusion bodies (HP:0100314)2.21210339
55Preaxial hand polydactyly (HP:0001177)2.19120633
56Stridor (HP:0010307)2.16453930
57Alacrima (HP:0000522)2.16398376
58Fair hair (HP:0002286)2.15205791
59Renal duplication (HP:0000075)2.14595799
60Reticulocytopenia (HP:0001896)2.08241216
61Chin dimple (HP:0010751)2.06194530
62High anterior hairline (HP:0009890)2.05429385
63Central scotoma (HP:0000603)1.99556669
64Preaxial foot polydactyly (HP:0001841)1.99456674
65Anencephaly (HP:0002323)1.98705456
66Hypoplastic labia majora (HP:0000059)1.98561617
67Abnormality of the septum pellucidum (HP:0007375)1.97579291
68Severe visual impairment (HP:0001141)1.94833991
69Abnormality of the vertebral endplates (HP:0005106)1.94710120
70Abnormality of the parietal bone (HP:0002696)1.93597317
71Genu valgum (HP:0002857)1.90851256
72Decreased central vision (HP:0007663)1.90348066
73Exotropia (HP:0000577)1.89388895
74Aplasia/Hypoplasia of the sternum (HP:0006714)1.86397115
75Abnormality of the right ventricle (HP:0001707)1.78658290
76Shallow orbits (HP:0000586)1.78541849
77Abnormality of glycolysis (HP:0004366)1.76449375
78Increased serum pyruvate (HP:0003542)1.76449375
79Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.75332392
80Short middle phalanx of the 5th finger (HP:0004220)1.74588207
81Difficulty running (HP:0009046)1.74233412
82Abdominal situs inversus (HP:0003363)1.73521679
83Abnormality of abdominal situs (HP:0011620)1.73521679
84Holoprosencephaly (HP:0001360)1.73426429
85Skull defect (HP:0001362)1.72552216
86Abnormality of the labia majora (HP:0012881)1.72438897
87Abnormality of the duodenum (HP:0002246)1.72029438
88Triangular face (HP:0000325)1.71709856
89Abnormality of the labia (HP:0000058)1.70541340
90Esophageal atresia (HP:0002032)1.70202386
91Abnormality of the pancreatic islet cells (HP:0006476)1.67642472
92Abnormality of endocrine pancreas physiology (HP:0012093)1.67642472
93Aplasia of the musculature (HP:0100854)1.67016004
94Choroideremia (HP:0001139)1.66974389
95Hepatoblastoma (HP:0002884)1.66860920
96Arterial tortuosity (HP:0005116)1.66681922
97Bile duct proliferation (HP:0001408)1.65724309
98Abnormal biliary tract physiology (HP:0012439)1.65724309
99Pancreatic fibrosis (HP:0100732)1.65507268
100Bifid scrotum (HP:0000048)1.65018349

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KSR17.56111208
2SIK37.33234007
3EPHB26.77746571
4BCR4.60396233
5NTRK12.87030644
6STK162.65930249
7ERBB22.42482692
8MINK12.11947555
9NTRK22.09144247
10EIF2AK31.82351283
11MARK11.58568016
12BUB11.43992011
13SIK11.43582604
14GRK71.37051538
15UHMK11.36013385
16DYRK31.25859806
17ERBB31.25368924
18MAP3K101.25028600
19WEE11.24910778
20MAP3K121.24056314
21CDK181.18630262
22PASK1.17538957
23IRAK21.08102246
24VRK11.05233275
25CDC70.87561679
26ROCK20.82986807
27ICK0.78549540
28BRSK10.78136978
29DYRK20.75631091
30CDK150.74726175
31TGFBR20.74290681
32NTRK30.73352755
33BCKDK0.72128046
34NEK60.70018614
35CDK140.65747472
36CDK11A0.65739915
37MAPKAPK50.62010937
38CSNK1G30.61537673
39PBK0.61383590
40CDK190.53994007
41FYN0.51236265
42DYRK1A0.50858996
43ADRBK10.49896712
44TGFBR10.49803448
45DYRK1B0.47640067
46PAK40.46250904
47SRC0.46070191
48CHUK0.45751931
49LIMK10.43964911
50PLK30.43348188
51ATR0.42881420
52MTOR0.42047084
53SRPK10.41561561
54IRAK10.40711471
55EIF2AK20.40433080
56PNCK0.39593993
57GRK60.37904730
58PLK10.37620301
59CDK80.37336663
60MAPKAPK20.37322144
61PLK20.35892429
62PRKCG0.35740231
63PRKCZ0.34205070
64DAPK10.33715964
65CAMK2B0.33418850
66CHEK20.33277521
67CSNK1E0.32395258
68CDK50.31975401
69AKT20.31948158
70AURKA0.30958069
71GRK50.29389213
72CSNK1G20.29363895
73PAK60.29124630
74MAP2K70.29079853
75MAPK90.28977525
76CSNK1A1L0.28879123
77CSNK1G10.28533480
78BRSK20.28181561
79FGFR20.27333129
80PRKACG0.26849538
81MELK0.26766547
82CSNK1D0.26646978
83CSF1R0.25880610
84CDK70.25562732
85SGK4940.22341909
86SGK2230.22341909
87CAMK2A0.19653131
88CDC42BPA0.18889375
89MAPK150.18691681
90WNK30.17971924
91CDK10.16473145
92MAPK80.15123922
93RPS6KA50.15015736
94PAK30.14822296
95CDK30.14812499
96CAMK2D0.14661669
97ROCK10.14015939
98PRKCB0.13673410
99CDK20.12567230
100NME20.12502063

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052176.07777108
2Hedgehog signaling pathway_Homo sapiens_hsa043404.25959031
3Notch signaling pathway_Homo sapiens_hsa043303.63236512
4Axon guidance_Homo sapiens_hsa043603.54118884
5Hippo signaling pathway_Homo sapiens_hsa043902.79965308
6DNA replication_Homo sapiens_hsa030302.68938911
7Melanogenesis_Homo sapiens_hsa049162.40674965
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.37695351
9Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.33554262
10Ribosome_Homo sapiens_hsa030102.28673975
11Cocaine addiction_Homo sapiens_hsa050302.12228592
12Wnt signaling pathway_Homo sapiens_hsa043102.12096315
13Spliceosome_Homo sapiens_hsa030401.96715313
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.94739434
15Vitamin B6 metabolism_Homo sapiens_hsa007501.86628650
16Cell cycle_Homo sapiens_hsa041101.82231536
17Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.79377013
18Dorso-ventral axis formation_Homo sapiens_hsa043201.37889224
19Alcoholism_Homo sapiens_hsa050341.31447273
20Parkinsons disease_Homo sapiens_hsa050121.23121184
21Nicotine addiction_Homo sapiens_hsa050331.21996322
22Oocyte meiosis_Homo sapiens_hsa041141.19131863
23Fatty acid elongation_Homo sapiens_hsa000621.18597680
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18564734
25TGF-beta signaling pathway_Homo sapiens_hsa043501.17857823
26Amphetamine addiction_Homo sapiens_hsa050311.13790863
27Alzheimers disease_Homo sapiens_hsa050101.09602878
28N-Glycan biosynthesis_Homo sapiens_hsa005101.08750759
29Circadian entrainment_Homo sapiens_hsa047131.07198647
30MicroRNAs in cancer_Homo sapiens_hsa052061.05098064
31Phenylalanine metabolism_Homo sapiens_hsa003601.02030666
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98402214
33Oxidative phosphorylation_Homo sapiens_hsa001900.96310421
34Tyrosine metabolism_Homo sapiens_hsa003500.93971429
35Huntingtons disease_Homo sapiens_hsa050160.93764323
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92754576
37HTLV-I infection_Homo sapiens_hsa051660.91533672
38Synaptic vesicle cycle_Homo sapiens_hsa047210.86390941
39Dopaminergic synapse_Homo sapiens_hsa047280.82489169
40Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78220738
41GABAergic synapse_Homo sapiens_hsa047270.75908874
42Pathways in cancer_Homo sapiens_hsa052000.74412308
43Pyrimidine metabolism_Homo sapiens_hsa002400.74219454
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73893763
45Bladder cancer_Homo sapiens_hsa052190.71440164
46Proteoglycans in cancer_Homo sapiens_hsa052050.70710497
47Base excision repair_Homo sapiens_hsa034100.69966197
48Chronic myeloid leukemia_Homo sapiens_hsa052200.69742955
49Tryptophan metabolism_Homo sapiens_hsa003800.69684313
50Nitrogen metabolism_Homo sapiens_hsa009100.67474069
51Insulin secretion_Homo sapiens_hsa049110.66642369
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65498179
53Arginine and proline metabolism_Homo sapiens_hsa003300.65255835
54Colorectal cancer_Homo sapiens_hsa052100.61472642
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57720510
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57374974
57Prion diseases_Homo sapiens_hsa050200.56210843
58Biosynthesis of amino acids_Homo sapiens_hsa012300.56184032
59Gap junction_Homo sapiens_hsa045400.55602179
60Glutamatergic synapse_Homo sapiens_hsa047240.55383628
61Serotonergic synapse_Homo sapiens_hsa047260.55358949
62mRNA surveillance pathway_Homo sapiens_hsa030150.53635948
63One carbon pool by folate_Homo sapiens_hsa006700.53052294
64ErbB signaling pathway_Homo sapiens_hsa040120.53048116
65Cardiac muscle contraction_Homo sapiens_hsa042600.53023102
66Fatty acid metabolism_Homo sapiens_hsa012120.52758689
67Systemic lupus erythematosus_Homo sapiens_hsa053220.52268292
68Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51817894
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51097849
70Arginine biosynthesis_Homo sapiens_hsa002200.50076611
71Mismatch repair_Homo sapiens_hsa034300.49771528
72Proteasome_Homo sapiens_hsa030500.49689096
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48477310
74Glioma_Homo sapiens_hsa052140.48434771
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47180889
76Thyroid hormone synthesis_Homo sapiens_hsa049180.45965666
77Morphine addiction_Homo sapiens_hsa050320.45686191
78Cholinergic synapse_Homo sapiens_hsa047250.45265788
79Butanoate metabolism_Homo sapiens_hsa006500.43769875
80Homologous recombination_Homo sapiens_hsa034400.43704536
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43669566
82Purine metabolism_Homo sapiens_hsa002300.43458358
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42829830
84Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42183935
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41488324
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40764311
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.39411586
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.37218475
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.35565104
90Estrogen signaling pathway_Homo sapiens_hsa049150.34883131
91Complement and coagulation cascades_Homo sapiens_hsa046100.34338204
92Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.33587330
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31083840
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30811289
95Renal cell carcinoma_Homo sapiens_hsa052110.29799179
96Linoleic acid metabolism_Homo sapiens_hsa005910.28289491
97Epstein-Barr virus infection_Homo sapiens_hsa051690.27543858
98Histidine metabolism_Homo sapiens_hsa003400.27368497
99RNA polymerase_Homo sapiens_hsa030200.25672230
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.25559149

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