FERMT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the fermitin family, and contains a FERM domain and a pleckstrin homology domain. The encoded protein is involved in integrin signaling and linkage of the actin cytoskeleton to the extracellular matrix. Mutations in this gene have been linked to Kindler syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)8.52723475
2bundle of His cell to Purkinje myocyte communication (GO:0086069)7.12954675
3desmosome organization (GO:0002934)6.90229527
4cell-substrate junction assembly (GO:0007044)6.83581552
5negative regulation of keratinocyte proliferation (GO:0010839)5.89427778
6intestinal epithelial cell development (GO:0060576)5.72145992
7regulation of chemokine secretion (GO:0090196)5.27779171
8interferon-gamma secretion (GO:0072643)5.19541882
9gap junction assembly (GO:0016264)4.86541017
10viral transcription (GO:0019083)4.80554165
11regulation of respiratory burst (GO:0060263)4.64994179
12regulation of water loss via skin (GO:0033561)4.62106040
13translational termination (GO:0006415)4.59708125
14hepatocyte apoptotic process (GO:0097284)4.57263463
15calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.53937367
16ribosomal small subunit assembly (GO:0000028)4.45025999
17intermediate filament organization (GO:0045109)4.39849960
18ribosomal large subunit biogenesis (GO:0042273)4.19032098
19ribosomal small subunit biogenesis (GO:0042274)4.13341455
20epidermis development (GO:0008544)4.11864736
21surfactant homeostasis (GO:0043129)4.09354290
22antibacterial humoral response (GO:0019731)4.07146016
23skin morphogenesis (GO:0043589)4.06778537
24intestinal absorption (GO:0050892)4.03451562
25tight junction assembly (GO:0070830)3.97045305
26establishment of skin barrier (GO:0061436)3.96584674
27positive regulation of epidermis development (GO:0045684)3.95569409
28antimicrobial humoral response (GO:0019730)3.92736043
29regulation of keratinocyte proliferation (GO:0010837)3.85651748
30dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.80822336
31regulation of transforming growth factor beta2 production (GO:0032909)3.80553954
32regulation of hair follicle development (GO:0051797)3.72641183
33negative regulation of chondrocyte differentiation (GO:0032331)3.71174157
34positive regulation of interleukin-8 secretion (GO:2000484)3.70633020
35branching involved in mammary gland duct morphogenesis (GO:0060444)3.69255152
36viral life cycle (GO:0019058)3.68568108
37SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.68016812
38maintenance of gastrointestinal epithelium (GO:0030277)3.66968427
39translational elongation (GO:0006414)3.66337570
40cell differentiation involved in embryonic placenta development (GO:0060706)3.65793851
41activation of Rac GTPase activity (GO:0032863)3.65491972
42epidermal cell differentiation (GO:0009913)3.63204405
43regulation of bile acid biosynthetic process (GO:0070857)3.62370412
44regulation of apoptotic process involved in morphogenesis (GO:1902337)3.60882142
45protein targeting to ER (GO:0045047)3.59541670
46cellular protein complex disassembly (GO:0043624)3.59082629
47cotranslational protein targeting to membrane (GO:0006613)3.56433529
48COPI coating of Golgi vesicle (GO:0048205)3.53998150
49Golgi transport vesicle coating (GO:0048200)3.53998150
50renal absorption (GO:0070293)3.53720359
51cellular response to vitamin D (GO:0071305)3.49967127
52multicellular organismal water homeostasis (GO:0050891)3.48458962
53polarized epithelial cell differentiation (GO:0030859)3.47825914
54diol metabolic process (GO:0034311)3.47125541
55maturation of SSU-rRNA (GO:0030490)3.45193285
56regulation of transforming growth factor beta1 production (GO:0032908)3.44198252
57establishment of protein localization to endoplasmic reticulum (GO:0072599)3.39782364
58ventricular cardiac muscle cell action potential (GO:0086005)3.37939851
59negative regulation of glial cell proliferation (GO:0060253)3.33190875
60receptor catabolic process (GO:0032801)3.31988084
61endodermal cell differentiation (GO:0035987)3.31333483
62positive regulation of Cdc42 GTPase activity (GO:0043089)3.29102259
63atrioventricular valve morphogenesis (GO:0003181)3.26597310
64nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.25726690
65establishment of tissue polarity (GO:0007164)3.24697986
66establishment of planar polarity (GO:0001736)3.24697986
67protein localization to endoplasmic reticulum (GO:0070972)3.24641083
68negative regulation of epidermal cell differentiation (GO:0045605)3.24395238
69chemical homeostasis within a tissue (GO:0048875)3.22605735
70protein localization to endosome (GO:0036010)3.22249320
71regulation of interleukin-8 secretion (GO:2000482)3.21416477
72phospholipid scrambling (GO:0017121)3.21170502
73cell junction assembly (GO:0034329)3.17672741
74sphingoid metabolic process (GO:0046519)3.16984430
75positive regulation of epidermal cell differentiation (GO:0045606)3.16352388
76epithelial cell differentiation involved in prostate gland development (GO:0060742)3.14886857
77negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.14483936
78intestinal cholesterol absorption (GO:0030299)3.12891289
79cytoskeletal anchoring at plasma membrane (GO:0007016)3.11617792
80renal system development (GO:0072001)3.10746587
81purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.10423968
823-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.10423968
83renal filtration (GO:0097205)3.10422441
84regulation of epidermis development (GO:0045682)3.09734181
85positive regulation of keratinocyte differentiation (GO:0045618)3.09267027
86negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.07953644
87mesodermal cell differentiation (GO:0048333)3.07862553
88positive regulation of chemokine secretion (GO:0090197)3.07688001
89* keratinocyte proliferation (GO:0043616)3.07591666
90cellular response to vitamin (GO:0071295)3.05967571
91regulation of cellular extravasation (GO:0002691)3.05037077
92cell-substrate adherens junction assembly (GO:0007045)3.04662053
93focal adhesion assembly (GO:0048041)3.04662053
94molting cycle (GO:0042303)3.04132672
95hair cycle (GO:0042633)3.04132672
96negative regulation of epidermis development (GO:0045683)3.03624946
97positive regulation of hair follicle development (GO:0051798)3.03492899
98positive regulation of hair cycle (GO:0042635)3.03492899
99positive regulation of pseudopodium assembly (GO:0031274)2.97963018
100protein complex disassembly (GO:0043241)2.96728653
101cell junction organization (GO:0034330)2.96501954
102keratinocyte development (GO:0003334)2.96315914
103keratinocyte differentiation (GO:0030216)2.94988698
104mammary gland epithelial cell proliferation (GO:0033598)2.94733457
105cytidine metabolic process (GO:0046087)2.94514104
106cytidine catabolic process (GO:0006216)2.94514104
107cytidine deamination (GO:0009972)2.94514104
108positive regulation of respiratory burst (GO:0060267)2.94392710
109regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.93507893
110transepithelial transport (GO:0070633)2.93473881
111collecting duct development (GO:0072044)2.93380664
112epithelial structure maintenance (GO:0010669)2.91435163
113ectoderm development (GO:0007398)2.90899720
114regulation of hydrogen peroxide metabolic process (GO:0010310)2.89309085
115regulation of keratinocyte differentiation (GO:0045616)2.89129813
116regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.88200527
117negative regulation of anoikis (GO:2000811)2.88053369
118nephron tubule formation (GO:0072079)2.87776999
119translational initiation (GO:0006413)2.86338046
120macromolecular complex disassembly (GO:0032984)2.85322940
121epithelial cell-cell adhesion (GO:0090136)2.84959938
122regulation of vitamin metabolic process (GO:0030656)2.84545646
123negative regulation of cell fate commitment (GO:0010454)2.83931514
124regulation of epidermal cell differentiation (GO:0045604)2.82271416
125water homeostasis (GO:0030104)2.81705477
126cardiovascular system development (GO:0072358)2.81705237
127sulfate transmembrane transport (GO:1902358)2.81576356
128regulation of hair cycle (GO:0042634)2.81485324
129regulation of cardioblast proliferation (GO:0003264)2.79706649
130regulation of secondary heart field cardioblast proliferation (GO:0003266)2.79706649
131mammary gland alveolus development (GO:0060749)2.79646720
132adherens junction assembly (GO:0034333)2.78012794
133neural crest cell development (GO:0014032)2.77973048
134virion attachment to host cell (GO:0019062)2.77142589
135adhesion of symbiont to host cell (GO:0044650)2.77142589
136positive regulation of digestive system process (GO:0060456)2.75327910
137O-glycan processing (GO:0016266)2.74894458
138cellular copper ion homeostasis (GO:0006878)2.72868828
139regulation of pseudopodium assembly (GO:0031272)2.72813596
140ribosome assembly (GO:0042255)2.72468464
141positive regulation of osteoblast proliferation (GO:0033690)2.71906556
142keratinization (GO:0031424)2.71689174
143L-serine transport (GO:0015825)2.71333085
144cell adhesion mediated by integrin (GO:0033627)2.71248876
145positive regulation of actin filament depolymerization (GO:0030836)2.70309858
146sphingosine metabolic process (GO:0006670)2.69325724
147hepatocyte differentiation (GO:0070365)2.69279047
148skin development (GO:0043588)2.68884724
149regulation of mesenchymal cell apoptotic process (GO:2001053)2.67317725
150cellular protein complex localization (GO:0034629)2.66009142
151morphogenesis of embryonic epithelium (GO:0016331)2.65711698
152mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.65311526
153peptide cross-linking (GO:0018149)2.65216464
154hypotonic response (GO:0006971)2.64800065
155regulation of cholesterol homeostasis (GO:2000188)2.64605101
156regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.64432962
157regulation of metalloenzyme activity (GO:0048552)2.64321217
158maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.63643724
159protein localization to microtubule (GO:0035372)2.62531022
160protein autoprocessing (GO:0016540)2.61373794
161nucleotide-sugar biosynthetic process (GO:0009226)2.61086762
162regulation of cardioblast differentiation (GO:0051890)2.59934288
163cell-cell junction assembly (GO:0007043)2.59105011
164nuclear pore complex assembly (GO:0051292)2.57991590
165positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.56461730
166regulation of transforming growth factor beta production (GO:0071634)2.56339912
167intermediate filament cytoskeleton organization (GO:0045104)2.55874368
168negative regulation of cell fate specification (GO:0009996)2.52131379
169regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.51224175
170semaphorin-plexin signaling pathway (GO:0071526)2.49281605
171negative regulation of stem cell proliferation (GO:2000647)2.47692630
172cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.47013014
173regulation of anoikis (GO:2000209)2.44607167
174protein retention in ER lumen (GO:0006621)2.43501784

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.74081000
2SMAD4_19686287_ChIP-ChIP_HaCaT_Human4.19402670
3CDX2_20551321_ChIP-Seq_CACO-2_Human3.94569632
4* SOX2_27498859_Chip-Seq_STOMACH_Mouse3.10191221
5ESR1_21235772_ChIP-Seq_MCF-7_Human2.97475900
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.78803415
7* GATA4_25053715_ChIP-Seq_YYC3_Human2.71611656
8SOX2_20726797_ChIP-Seq_SW620_Human2.71379101
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.48899593
10GATA6_25053715_ChIP-Seq_YYC3_Human2.48141122
11CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.41188556
12E2F7_22180533_ChIP-Seq_HELA_Human2.34989665
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.28550495
14SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.24470785
15SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.24470785
16SOX9_24532713_ChIP-Seq_HFSC_Mouse2.16279756
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.14725983
18FOXO3_23340844_ChIP-Seq_DLD1_Human2.04332941
19FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.02292502
20AR_21909140_ChIP-Seq_LNCAP_Human2.01894782
21TP63_17297297_ChIP-ChIP_HaCaT_Human14.1706841
22* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.96558923
23* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.96164566
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.90118211
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.79756672
26PPAR_26484153_Chip-Seq_NCI-H1993_Human1.68495886
27* KLF5_25053715_ChIP-Seq_YYC3_Human1.63930752
28RUNX1_27514584_Chip-Seq_MCF-7_Human1.60857027
29ZNF217_24962896_ChIP-Seq_MCF-7_Human1.58893329
30KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.57251356
31FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.55312622
32TCF4_18268006_ChIP-ChIP_LS174T_Human1.51478313
33ESR1_20079471_ChIP-ChIP_T-47D_Human1.48503216
34PPARA_22158963_ChIP-Seq_LIVER_Mouse1.46709943
35ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.38877389
36POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.38748909
37SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.38371854
38P300_27058665_Chip-Seq_ZR-75-30cells_Human1.35868660
39ATF3_27146783_Chip-Seq_COLON_Human1.35243605
40GATA3_24758297_ChIP-Seq_MCF-7_Human1.34439648
41RACK7_27058665_Chip-Seq_MCF-7_Human1.32610087
42ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.30269337
43ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.28841464
44CJUN_26792858_Chip-Seq_BT549_Human1.28769890
45KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28353057
46ELK3_25401928_ChIP-Seq_HUVEC_Human1.27979283
47TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25759132
48MYC_18555785_ChIP-Seq_MESCs_Mouse1.25009283
49FOXM1_26456572_ChIP-Seq_MCF-7_Human1.24069868
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23416062
51TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.23054036
52TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22049269
53KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20076782
54BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.17183013
55HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17154413
56EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.09795651
57SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08867291
58RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05969090
59FOXM1_23109430_ChIP-Seq_U2OS_Human1.04661543
60HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04227854
61CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.03032206
62KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01863835
63PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.01821246
64DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01494525
65ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01365869
66CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00883529
67TP53_22127205_ChIP-Seq_IMR90_Human0.98191732
68JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97986353
69LXR_22158963_ChIP-Seq_LIVER_Mouse0.97733954
70RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97368457
71TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97279632
72CLOCK_20551151_ChIP-Seq_293T_Human0.97238528
73NANOG_18555785_ChIP-Seq_MESCs_Mouse0.96797814
74ELK1_22589737_ChIP-Seq_MCF10A_Human0.96138150
75EGR1_23403033_ChIP-Seq_LIVER_Mouse0.94642975
76ZFX_18555785_ChIP-Seq_MESCs_Mouse0.94602730
77MYC_19079543_ChIP-ChIP_MESCs_Mouse0.92459189
78EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.91931731
79NANOG_18692474_ChIP-Seq_MEFs_Mouse0.91476178
80RXR_22158963_ChIP-Seq_LIVER_Mouse0.91328818
81AHR_22903824_ChIP-Seq_MCF-7_Human0.91129101
82ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90108154
83NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.88770669
84CHD1_26751641_Chip-Seq_LNCaP_Human0.88710060
85PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.87821292
86* TP63_23658742_ChIP-Seq_EP156T_Human0.87482345
87NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.87452772
88TCF3_18692474_ChIP-Seq_MEFs_Mouse0.86352668
89* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.86003862
90WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.85405882
91NELFA_20434984_ChIP-Seq_ESCs_Mouse0.83748684
92CTNNB1_20460455_ChIP-Seq_HCT116_Human0.82763489
93ZNF263_19887448_ChIP-Seq_K562_Human0.82439393
94PIAS1_25552417_ChIP-Seq_VCAP_Human0.81935761
95ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.81202583
96GATA2_21666600_ChIP-Seq_HMVEC_Human0.79910264
97* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78897635
98CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.78735575
99CDX2_22108803_ChIP-Seq_LS180_Human0.78719582
100FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.78486861
101PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.78403914
102UBF1/2_26484160_Chip-Seq_HMECs_Human0.77456785
103NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.77037879
104SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.76553673
105LXR_22292898_ChIP-Seq_THP-1_Human0.76337019
106FOXA1_25552417_ChIP-Seq_VCAP_Human0.76169265
107GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.75603794
108NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.75123302
109STAT3_1855785_ChIP-Seq_MESCs_Mouse0.74840427
110SALL4_18804426_ChIP-ChIP_XEN_Mouse0.74601862
111* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.74409088
112PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.73118578
113ELF5_23300383_ChIP-Seq_T47D_Human0.72792279
114* TP63_22573176_ChIP-Seq_HFKS_Human0.72285462
115NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.70631324
116FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.70440603
117KAP1_27257070_Chip-Seq_ESCs_Mouse0.70273155
118TP53_18474530_ChIP-ChIP_U2OS_Human0.70141136
119EGR1_19032775_ChIP-ChIP_M12_Human0.69721697
120NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.69101926
121AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.67680055
122ISL1_27105846_Chip-Seq_CPCs_Mouse0.66980312
123BCAT_22108803_ChIP-Seq_LS180_Human0.66709782
124TP53_16413492_ChIP-PET_HCT116_Human0.65738137
125JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.65462914
126SOX2_18692474_ChIP-Seq_MEFs_Mouse0.65020512
127FOXA2_19822575_ChIP-Seq_HepG2_Human0.64747664
128STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.64075403
129ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.63893956
130SMAD3_21741376_ChIP-Seq_HESCs_Human0.63604692
131UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.62912371
132ARNT_22903824_ChIP-Seq_MCF-7_Human0.62376075
133RXR_22108803_ChIP-Seq_LS180_Human0.60882647
134ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.60795006

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat5.00931638
2MP0010234_abnormal_vibrissa_follicle4.81161875
3MP0000537_abnormal_urethra_morphology3.71630443
4MP0008004_abnormal_stomach_pH3.53854463
5MP0009379_abnormal_foot_pigmentation3.43997972
6MP0004264_abnormal_extraembryonic_tissu3.19507978
7MP0002796_impaired_skin_barrier3.07992359
8MP0003941_abnormal_skin_development2.92618512
9MP0001346_abnormal_lacrimal_gland2.86990561
10MP0000462_abnormal_digestive_system2.77817196
11MP0005409_darkened_coat_color2.66987505
12MP0010678_abnormal_skin_adnexa2.66563447
13MP0003300_gastrointestinal_ulcer2.61217907
14MP0000566_synostosis2.60891349
15MP0002098_abnormal_vibrissa_morphology2.44239844
16MP0000383_abnormal_hair_follicle2.42382727
17MP0001873_stomach_inflammation2.40463441
18MP0001666_abnormal_nutrient_absorption2.39477901
19MP0002138_abnormal_hepatobiliary_system2.21299161
20MP0000538_abnormal_urinary_bladder2.07266237
21MP0005360_urolithiasis2.02817307
22MP0005501_abnormal_skin_physiology1.98920811
23* MP0010155_abnormal_intestine_physiology1.91142507
24* MP0003453_abnormal_keratinocyte_physiol1.88813663
25MP0000579_abnormal_nail_morphology1.87251994
26* MP0001216_abnormal_epidermal_layer1.84443168
27MP0000467_abnormal_esophagus_morphology1.75716354
28MP0010030_abnormal_orbit_morphology1.75427401
29MP0000490_abnormal_crypts_of1.74235452
30MP0000762_abnormal_tongue_morphology1.73003442
31MP0004019_abnormal_vitamin_homeostasis1.72160111
32MP0001849_ear_inflammation1.71016253
33* MP0002060_abnormal_skin_morphology1.68980123
34MP0005257_abnormal_intraocular_pressure1.62840448
35MP0005381_digestive/alimentary_phenotyp1.59414651
36MP0003866_abnormal_defecation1.58790803
37MP0001663_abnormal_digestive_system1.56707081
38MP0002277_abnormal_respiratory_mucosa1.54463239
39MP0001664_abnormal_digestion1.53788408
40MP0002877_abnormal_melanocyte_morpholog1.53489808
41MP0005367_renal/urinary_system_phenotyp1.53474755
42MP0000516_abnormal_urinary_system1.53474755
43MP0003191_abnormal_cellular_cholesterol1.52955960
44MP0000613_abnormal_salivary_gland1.50613759
45MP0010352_gastrointestinal_tract_polyps1.47187962
46MP0003315_abnormal_perineum_morphology1.44671493
47MP0003283_abnormal_digestive_organ1.41140166
48MP0005085_abnormal_gallbladder_physiolo1.38826777
49MP0005084_abnormal_gallbladder_morpholo1.36049731
50* MP0010771_integument_phenotype1.35407931
51MP0000377_abnormal_hair_follicle1.34609267
52* MP0000477_abnormal_intestine_morphology1.33449249
53MP0005275_abnormal_skin_tensile1.33272584
54* MP0000470_abnormal_stomach_morphology1.33172283
55MP0004947_skin_inflammation1.28102258
56MP0003705_abnormal_hypodermis_morpholog1.27928967
57MP0009780_abnormal_chondrocyte_physiolo1.27602427
58MP0000427_abnormal_hair_cycle1.24602009
59MP0004957_abnormal_blastocyst_morpholog1.24584036
60MP0003252_abnormal_bile_duct1.20359477
61MP0009053_abnormal_anal_canal1.17692916
62MP0003566_abnormal_cell_adhesion1.11630299
63MP0005076_abnormal_cell_differentiation1.08796951
64MP0001348_abnormal_lacrimal_gland1.07363662
65MP0003950_abnormal_plasma_membrane1.05801135
66MP0005310_abnormal_salivary_gland1.05062274
67MP0000647_abnormal_sebaceous_gland1.03373629
68* MP0009643_abnormal_urine_homeostasis1.02253032
69MP0004185_abnormal_adipocyte_glucose1.00480467
70MP0008260_abnormal_autophagy1.00187323
71MP0005451_abnormal_body_composition0.99883778
72MP0000678_abnormal_parathyroid_gland0.99203117
73MP0002234_abnormal_pharynx_morphology0.98256325
74MP0005377_hearing/vestibular/ear_phenot0.97089153
75MP0003878_abnormal_ear_physiology0.97089153
76MP0009384_cardiac_valve_regurgitation0.96082486
77MP0000627_abnormal_mammary_gland0.95510419
78MP0003693_abnormal_embryo_hatching0.94035631
79MP0006054_spinal_hemorrhage0.93570907
80MP0002876_abnormal_thyroid_physiology0.90903048
81MP0001765_abnormal_ion_homeostasis0.89921304
82MP0002089_abnormal_postnatal_growth/wei0.89172903
83MP0001191_abnormal_skin_condition0.87440443
84MP0005365_abnormal_bile_salt0.86938025
85MP0002928_abnormal_bile_duct0.86670521
86MP0000367_abnormal_coat/_hair0.86522642
87MP0003755_abnormal_palate_morphology0.82412941
88MP0005220_abnormal_exocrine_pancreas0.81889477
89MP0004381_abnormal_hair_follicle0.80840173
90MP0004272_abnormal_basement_membrane0.80617663
91MP0008932_abnormal_embryonic_tissue0.79753622
92MP0008872_abnormal_physiological_respon0.79095842
93MP0005023_abnormal_wound_healing0.76830163
94MP0004043_abnormal_pH_regulation0.75747145
95MP0002111_abnormal_tail_morphology0.75244902
96MP0002086_abnormal_extraembryonic_tissu0.75078405
97MP0003091_abnormal_cell_migration0.74353954
98MP0002697_abnormal_eye_size0.74102058
99MP0003119_abnormal_digestive_system0.73996630
100MP0005083_abnormal_biliary_tract0.73589110
101MP0001730_embryonic_growth_arrest0.73166979
102* MP0002136_abnormal_kidney_physiology0.73027553
103MP0003806_abnormal_nucleotide_metabolis0.70766703
104MP0004782_abnormal_surfactant_physiolog0.70440503
105MP0002132_abnormal_respiratory_system0.69804426
106MP0005666_abnormal_adipose_tissue0.69192287
107MP0001756_abnormal_urination0.68826513
108MP0009931_abnormal_skin_appearance0.68178281
109MP0000350_abnormal_cell_proliferation0.67840687
110MP0004858_abnormal_nervous_system0.67607306
111MP0001340_abnormal_eyelid_morphology0.67075961
112MP0002177_abnormal_outer_ear0.66405655
113MP0001881_abnormal_mammary_gland0.64940692
114MP0002896_abnormal_bone_mineralization0.64332454
115MP0002233_abnormal_nose_morphology0.64204018
116MP0003329_amyloid_beta_deposits0.64186187
117MP0003936_abnormal_reproductive_system0.63593142
118MP0001485_abnormal_pinna_reflex0.62987673
119MP0000858_altered_metastatic_potential0.61764665
120MP0002009_preneoplasia0.61064415
121MP0000003_abnormal_adipose_tissue0.60149158
122MP0002139_abnormal_hepatobiliary_system0.59757887
123MP0005248_abnormal_Harderian_gland0.59695262
124MP0008007_abnormal_cellular_replicative0.59363000
125MP0010368_abnormal_lymphatic_system0.59018843
126MP0004197_abnormal_fetal_growth/weight/0.58901339
127MP0003115_abnormal_respiratory_system0.57533208
128MP0001851_eye_inflammation0.56745248
129MP0005621_abnormal_cell_physiology0.55931801
130MP0003937_abnormal_limbs/digits/tail_de0.55536860
131MP0005375_adipose_tissue_phenotype0.55373114
132MP0002006_tumorigenesis0.55262057
133MP0000432_abnormal_head_morphology0.55259530
134MP0005636_abnormal_mineral_homeostasis0.55043743
135MP0000733_abnormal_muscle_development0.55002694
136MP0001915_intracranial_hemorrhage0.54587785
137MP0002084_abnormal_developmental_patter0.53533257
138MP0001299_abnormal_eye_distance/0.53039507
139MP0003385_abnormal_body_wall0.52543199
140MP0003984_embryonic_growth_retardation0.51815067
141MP0005380_embryogenesis_phenotype0.51680688
142MP0001672_abnormal_embryogenesis/_devel0.51680688
143MP0005197_abnormal_uvea_morphology0.50108701
144MP0003935_abnormal_craniofacial_develop0.48284165
145MP0001243_abnormal_dermal_layer0.47092840
146MP0005193_abnormal_anterior_eye0.46055438
147MP0002088_abnormal_embryonic_growth/wei0.45854436
148MP0002080_prenatal_lethality0.45538677

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)6.81369745
2Onycholysis (HP:0001806)6.69099627
3Right ventricular cardiomyopathy (HP:0011663)6.09881809
4Fragile nails (HP:0001808)5.80640433
5Milia (HP:0001056)5.69012016
6Thick nail (HP:0001805)5.55581490
7Ileus (HP:0002595)5.00098381
8Abnormal hemoglobin (HP:0011902)4.43396398
9Atrophic scars (HP:0001075)4.42044202
10* Plantar hyperkeratosis (HP:0007556)4.40466016
11Ventricular fibrillation (HP:0001663)4.19453942
12Pili torti (HP:0003777)4.13606944
13Woolly hair (HP:0002224)4.07400571
14Selective tooth agenesis (HP:0001592)3.74835342
15Congenital sensorineural hearing impairment (HP:0008527)3.62061026
16Reticulocytopenia (HP:0001896)3.34405270
17Rectal prolapse (HP:0002035)3.30636512
18* Ridged nail (HP:0001807)3.30470809
19Nail dystrophy (HP:0008404)3.27757011
20Alopecia of scalp (HP:0002293)3.21601486
21Hypoplasia of dental enamel (HP:0006297)3.21077715
22Abnormality of chloride homeostasis (HP:0011422)3.09565452
23Aplasia cutis congenita (HP:0001057)3.02188659
24Micronodular cirrhosis (HP:0001413)2.93821232
25Metabolic alkalosis (HP:0200114)2.93004771
26Abnormality of cells of the erythroid lineage (HP:0012130)2.91359396
27Hyperactive renin-angiotensin system (HP:0000841)2.89132796
28Dehydration (HP:0001944)2.87618486
29Lip pit (HP:0100267)2.84605773
30Oligodontia (HP:0000677)2.84028213
31Oral leukoplakia (HP:0002745)2.82829400
32Abnormality of the salivary glands (HP:0010286)2.81661979
33Ureteral stenosis (HP:0000071)2.74995458
34Abnormal number of erythroid precursors (HP:0012131)2.67687342
35Advanced eruption of teeth (HP:0006288)2.67558991
36* Abnormality of the gastric mucosa (HP:0004295)2.62184853
37* Fragile skin (HP:0001030)2.61254640
38Abnormal hair laboratory examination (HP:0003328)2.56168357
39Curly hair (HP:0002212)2.55220898
40Anonychia (HP:0001798)2.54047734
41Biliary tract neoplasm (HP:0100574)2.51753616
42* Abnormal blistering of the skin (HP:0008066)2.51736521
43Absent eyelashes (HP:0000561)2.49981015
44Abnormal biliary tract morphology (HP:0012440)2.48870324
45Ureteral obstruction (HP:0006000)2.47237749
46Abnormality of glutamine family amino acid metabolism (HP:0010902)2.45693640
47Corneal erosion (HP:0200020)2.43718138
48Abnormality of the 1st metacarpal (HP:0010009)2.43274909
49Hypoplasia of the uterus (HP:0000013)2.41095167
50Conjugated hyperbilirubinemia (HP:0002908)2.38193034
51Macrocytic anemia (HP:0001972)2.36363277
52Broad face (HP:0000283)2.34284031
53Abnormality of the 2nd finger (HP:0004100)2.30632224
54Esophageal atresia (HP:0002032)2.29646002
55Unilateral renal agenesis (HP:0000122)2.28480233
56Pterygium (HP:0001059)2.26545529
57Abnormality of the distal phalanges of the toes (HP:0010182)2.26301317
58Abnormality of the axillary hair (HP:0100134)2.22974551
59Abnormality of secondary sexual hair (HP:0009888)2.22974551
60Hypotrichosis (HP:0001006)2.22538022
61Deviation of the thumb (HP:0009603)2.22046012
62Stenosis of the external auditory canal (HP:0000402)2.21893372
63Erythema (HP:0010783)2.20064181
64Parakeratosis (HP:0001036)2.18569237
65Focal segmental glomerulosclerosis (HP:0000097)2.18300536
66Amelogenesis imperfecta (HP:0000705)2.18011410
67Sparse eyelashes (HP:0000653)2.17679437
68Abdominal distention (HP:0003270)2.16852598
69* Palmoplantar hyperkeratosis (HP:0000972)2.16641348
70Short nail (HP:0001799)2.15781223
71Aplasia/hypoplasia of the uterus (HP:0008684)2.15480680
7211 pairs of ribs (HP:0000878)2.14981529
73Symphalangism affecting the phalanges of the hand (HP:0009773)2.14414740
74Congenital, generalized hypertrichosis (HP:0004540)2.13524198
75Congenital ichthyosiform erythroderma (HP:0007431)2.13419030
76Abnormality of small intestinal villus morphology (HP:0011472)2.13355961
77Villous atrophy (HP:0011473)2.13355961
78Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.11740287
79Abnormality of urine glucose concentration (HP:0011016)2.11558176
80Glycosuria (HP:0003076)2.11558176
81* Carious teeth (HP:0000670)2.11358017
82Septate vagina (HP:0001153)2.11075575
83Thin bony cortex (HP:0002753)2.09970550
84Dry hair (HP:0011359)2.08451891
85Ectropion (HP:0000656)2.07648066
86Hydroxyprolinuria (HP:0003080)2.07525770
87Abnormality of proline metabolism (HP:0010907)2.07525770
88Flat acetabular roof (HP:0003180)2.06952345
89Glomerulosclerosis (HP:0000096)2.06423651
90Widely patent fontanelles and sutures (HP:0004492)2.06048608
91Esophageal varix (HP:0002040)2.04785424
92* Ankyloglossia (HP:0010296)2.04138606
93Popliteal pterygium (HP:0009756)2.02549557
94* Palmar hyperkeratosis (HP:0010765)2.02118917
95* Palmoplantar keratoderma (HP:0000982)2.01221245
96Hyperhidrosis (HP:0000975)1.96586319
97Abnormality of carpal bone ossification (HP:0006257)1.96564189
98Abnormality of the middle phalanges of the toes (HP:0010183)1.96418349
99Abnormality of the distal phalanx of the thumb (HP:0009617)1.95830054
100Colon cancer (HP:0003003)1.94116455
101Abnormal pancreas size (HP:0012094)1.93592050
102Abnormality of the labia majora (HP:0012881)1.93239666
103Abnormal tarsal ossification (HP:0008369)1.93222213
104Malnutrition (HP:0004395)1.92429316
105Lipid accumulation in hepatocytes (HP:0006561)1.91470930
106Short phalanx of the thumb (HP:0009660)1.87360142
107Uterine neoplasm (HP:0010784)1.86493294
108Osteolytic defects of the phalanges of the hand (HP:0009771)1.86030163
109Osteolytic defects of the hand bones (HP:0009699)1.86030163
110Hyperphosphaturia (HP:0003109)1.85111624
111Ventricular tachycardia (HP:0004756)1.84844252
112Abnormality of renal resorption (HP:0011038)1.84389457
113Abnormal ossification of hand bones (HP:0005921)1.83562314
114Proximal placement of thumb (HP:0009623)1.82985470
115Pallor (HP:0000980)1.82556973
116Increased hepatocellular lipid droplets (HP:0006565)1.82140535
117Fatigable weakness (HP:0003473)1.81962191
118Abnormality of the neuromuscular junction (HP:0003398)1.81962191
119Down-sloping shoulders (HP:0200021)1.81655437
120Blepharitis (HP:0000498)1.81072482
121Absent eyebrow (HP:0002223)1.80173868
122Breast hypoplasia (HP:0003187)1.79389698
123* Abnormality of the fingernails (HP:0001231)1.79260051
124Partial duplication of thumb phalanx (HP:0009944)1.78970096
125Nasolacrimal duct obstruction (HP:0000579)1.78751648
126Sparse scalp hair (HP:0002209)1.77600861
127Vascular calcification (HP:0004934)1.77301329
128Hoarse voice (HP:0001609)1.75874788
129Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.75199567
130Gout (HP:0001997)1.74717319
131* Pustule (HP:0200039)1.74053040
132Natal tooth (HP:0000695)1.73729810
133Hyperphosphatemia (HP:0002905)1.73606350
134Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.73066174
135Hypoplastic labia majora (HP:0000059)1.72763364
136Hypokalemic alkalosis (HP:0001949)1.72725672
137Hypodontia (HP:0000668)1.71556169
138Hyperacusis (HP:0010780)1.70946942
139Death in infancy (HP:0001522)1.69248444
140Insomnia (HP:0100785)1.66477397
141Erythroderma (HP:0001019)1.65247820
142* Abnormality of oral frenula (HP:0000190)1.63459662
143Abnormal hand bone ossification (HP:0010660)1.62552928
144Laryngomalacia (HP:0001601)1.62482990
145Neonatal death (HP:0003811)1.60865556
146Tibial bowing (HP:0002982)1.59499569
147Cardiovascular calcification (HP:0011915)1.58515554
148Neurofibrillary tangles (HP:0002185)1.58419781
149Multifactorial inheritance (HP:0001426)1.54930179
150Subacute progressive viral hepatitis (HP:0006572)1.54521365
151Hypohidrosis (HP:0000966)1.53187745
152Abnormality of permanent molar morphology (HP:0011071)1.52657604
153Abnormality of the dental root (HP:0006486)1.52657604
154Taurodontia (HP:0000679)1.52657604
155Abnormality of the lacrimal duct (HP:0011481)1.50917227
156Cervical subluxation (HP:0003308)1.50557277

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA26.26173738
2LMTK24.44691612
3MST44.17933148
4MST1R3.63256127
5FRK3.17893136
6PBK2.62263546
7MAP2K22.52708031
8NUAK12.52354509
9EPHB22.45251308
10NME12.34572359
11MAP3K92.00733838
12STK241.96582002
13LATS11.94263132
14PRKG21.91934041
15RIPK11.90501115
16MAP3K31.88952197
17LATS21.86971802
18FER1.85536242
19RPS6KB21.84486502
20PIK3CA1.84442168
21STK391.78772025
22ARAF1.72044238
23MAP3K21.70118889
24SMG11.63608579
25NTRK11.62505019
26OXSR11.59305719
27TTK1.54580638
28PTK61.49919576
29PTK21.48586860
30STK38L1.48159413
31WNK41.40724799
32PAK41.37986143
33TRIB31.36211574
34MAP2K61.35704499
35MAP3K141.34992972
36ERBB21.31960361
37MAPK151.30618981
38EPHB11.17853716
39SCYL21.16442836
40TGFBR11.14646562
41BCR1.11633975
42MET1.09271554
43NEK91.05731671
44ICK1.05199665
45FLT31.03052585
46ERN11.01380173
47TESK11.00797405
48PRKCI1.00418017
49LRRK20.99501280
50EEF2K0.94908551
51ERBB40.91819680
52AURKB0.89563981
53MAP3K120.87961124
54DYRK1B0.86079969
55DDR20.85383792
56MYLK0.84829040
57CHUK0.83439092
58BMPR1B0.82838433
59CDK120.81018095
60STK100.79833452
61FGFR40.76745498
62IRAK30.75174625
63PDGFRB0.73387295
64CDK60.73102945
65EPHA30.72355613
66DMPK0.71725375
67MAP2K10.70725625
68TLK10.70015410
69MAP3K110.67609996
70SIK10.66094469
71NEK10.65617726
72MATK0.65594214
73PHKG10.62911529
74PHKG20.62911529
75PKN20.59674714
76BUB10.59415265
77PRPF4B0.59055295
78TTN0.58617497
79WNK30.57567808
80MTOR0.57225505
81MAP3K130.56952059
82DYRK30.56702791
83STK30.55860982
84KSR20.50221888
85IKBKE0.48796350
86CDK80.48549240
87NME20.48413526
88BRAF0.47164530
89ZAK0.45852270
90MAPKAPK30.45521984
91ROCK10.44274879
92PIK3CG0.43971057
93TSSK60.42990504
94MAP3K60.42598470
95TGFBR20.42393979
96GRK10.41646773
97TAOK30.41613939
98FGFR20.40677086
99CDK90.38978123
100RPS6KA40.38927249
101TBK10.38741590
102IKBKB0.38049239
103MELK0.37994396
104NLK0.37785026
105KSR10.37115642
106MAP3K80.34966529
107GSK3A0.34616892
108NEK60.34490524
109TRPM70.33218530
110MAP3K100.33072695
111ABL20.33022937
112CAMK2G0.32735409
113EIF2AK30.32554320
114MAPKAPK20.31230744
115NEK20.31117023
116PDGFRA0.30362957
117CAMK1D0.30267476
118FGFR10.29797957
119RPS6KB10.29418699
120VRK10.29380272
121CAMK2D0.29025805
122PAK20.28730167
123ERBB30.28646744
124ROCK20.27568244
125CDC42BPA0.27447791
126EIF2AK10.27309688
127PIM20.27051894
128RET0.26759387
129PRKCA0.26588504
130AKT20.26087743
131ILK0.25791818
132CSF1R0.25336746
133PRKAA20.25193891
134SRC0.25101271
135CDK70.24470940
136SRPK10.24164600
137MAP3K10.24002075
138CSNK1A10.23911016
139STK380.23474960
140WNK10.23354634
141BMX0.22717138
142RAF10.22353262
143EIF2AK20.21971997
144CAMK1G0.21014669

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009203.88026195
2Ribosome_Homo sapiens_hsa030103.87968269
3Cyanoamino acid metabolism_Homo sapiens_hsa004603.11787498
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.92987269
5Mineral absorption_Homo sapiens_hsa049782.73047748
6Histidine metabolism_Homo sapiens_hsa003402.43255496
7Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.35081660
8Fat digestion and absorption_Homo sapiens_hsa049752.31078924
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.30914502
10Glutathione metabolism_Homo sapiens_hsa004802.12007934
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.10400833
12Protein digestion and absorption_Homo sapiens_hsa049742.02296189
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.98006215
14Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.92681488
15Tight junction_Homo sapiens_hsa045301.91841765
16Bladder cancer_Homo sapiens_hsa052191.82868657
17Oxidative phosphorylation_Homo sapiens_hsa001901.82702197
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.80366556
19Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.70758984
20Vitamin digestion and absorption_Homo sapiens_hsa049771.63688612
21ECM-receptor interaction_Homo sapiens_hsa045121.62370518
22Central carbon metabolism in cancer_Homo sapiens_hsa052301.61744818
23Chemical carcinogenesis_Homo sapiens_hsa052041.57013201
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.56563963
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.55988282
26Pancreatic secretion_Homo sapiens_hsa049721.53775822
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.53057838
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49257151
29Arginine biosynthesis_Homo sapiens_hsa002201.47636150
30MicroRNAs in cancer_Homo sapiens_hsa052061.43728768
31Adherens junction_Homo sapiens_hsa045201.42009280
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.36322566
33Parkinsons disease_Homo sapiens_hsa050121.34646847
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.34546472
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.34221514
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.33699307
37Arachidonic acid metabolism_Homo sapiens_hsa005901.33408013
38Chronic myeloid leukemia_Homo sapiens_hsa052201.32933871
39ErbB signaling pathway_Homo sapiens_hsa040121.31312846
40Small cell lung cancer_Homo sapiens_hsa052221.30980689
41Alzheimers disease_Homo sapiens_hsa050101.30682991
42Basal cell carcinoma_Homo sapiens_hsa052171.30601343
43Retinol metabolism_Homo sapiens_hsa008301.26143500
44Linoleic acid metabolism_Homo sapiens_hsa005911.24812077
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.15921104
46Pancreatic cancer_Homo sapiens_hsa052121.15611759
47Intestinal immune network for IgA production_Homo sapiens_hsa046721.14583308
48Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.14557956
49Regulation of actin cytoskeleton_Homo sapiens_hsa048101.13300965
50N-Glycan biosynthesis_Homo sapiens_hsa005101.12580838
51Endometrial cancer_Homo sapiens_hsa052131.11576396
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10590686
53Hippo signaling pathway_Homo sapiens_hsa043901.09414546
54Biosynthesis of amino acids_Homo sapiens_hsa012301.07581566
55Fatty acid biosynthesis_Homo sapiens_hsa000611.07141537
56Bile secretion_Homo sapiens_hsa049761.06677326
57Vitamin B6 metabolism_Homo sapiens_hsa007501.05004305
58Steroid biosynthesis_Homo sapiens_hsa001001.04488292
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04464216
60Folate biosynthesis_Homo sapiens_hsa007901.03143851
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03100004
62Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.01647817
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99687300
64Tryptophan metabolism_Homo sapiens_hsa003800.99581644
65Renin-angiotensin system_Homo sapiens_hsa046140.99228143
66Thyroid cancer_Homo sapiens_hsa052160.98659926
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.97330269
68Fatty acid degradation_Homo sapiens_hsa000710.96917366
69Hepatitis C_Homo sapiens_hsa051600.96414974
70Renal cell carcinoma_Homo sapiens_hsa052110.96398807
71Prion diseases_Homo sapiens_hsa050200.95234774
72Notch signaling pathway_Homo sapiens_hsa043300.92869084
73Shigellosis_Homo sapiens_hsa051310.92597239
74Fructose and mannose metabolism_Homo sapiens_hsa000510.90729786
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.89508989
76beta-Alanine metabolism_Homo sapiens_hsa004100.87245395
77Huntingtons disease_Homo sapiens_hsa050160.86704602
78VEGF signaling pathway_Homo sapiens_hsa043700.86641518
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85297170
80Axon guidance_Homo sapiens_hsa043600.83784247
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.82050512
82Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.81403011
83Toxoplasmosis_Homo sapiens_hsa051450.81229042
842-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80081529
85Cell cycle_Homo sapiens_hsa041100.80066899
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79882472
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79640236
88Phenylalanine metabolism_Homo sapiens_hsa003600.77688090
89Starch and sucrose metabolism_Homo sapiens_hsa005000.76639347
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76317752
91Sphingolipid metabolism_Homo sapiens_hsa006000.76076557
92Arginine and proline metabolism_Homo sapiens_hsa003300.75961707
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75021174
94Glycerolipid metabolism_Homo sapiens_hsa005610.74617321
95Insulin signaling pathway_Homo sapiens_hsa049100.73911137
96PI3K-Akt signaling pathway_Homo sapiens_hsa041510.72426178
97Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72066702
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70864217
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.68932856
100TNF signaling pathway_Homo sapiens_hsa046680.68475765
101p53 signaling pathway_Homo sapiens_hsa041150.68445886
102Hematopoietic cell lineage_Homo sapiens_hsa046400.67633770
103Gastric acid secretion_Homo sapiens_hsa049710.66617450
104Thyroid hormone synthesis_Homo sapiens_hsa049180.64775850
105Inositol phosphate metabolism_Homo sapiens_hsa005620.63825984
106AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63688775
107Butanoate metabolism_Homo sapiens_hsa006500.63489021
108Salmonella infection_Homo sapiens_hsa051320.63150165
109Glioma_Homo sapiens_hsa052140.63062783
110Galactose metabolism_Homo sapiens_hsa000520.62627355
111Endocytosis_Homo sapiens_hsa041440.61914943
112Non-small cell lung cancer_Homo sapiens_hsa052230.61780196
113Dilated cardiomyopathy_Homo sapiens_hsa054140.57245517
114Carbon metabolism_Homo sapiens_hsa012000.55350759
115Influenza A_Homo sapiens_hsa051640.54057467
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53889616
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53453418
118Proteoglycans in cancer_Homo sapiens_hsa052050.53018419
119PPAR signaling pathway_Homo sapiens_hsa033200.52877273
120Hedgehog signaling pathway_Homo sapiens_hsa043400.52847596
121Legionellosis_Homo sapiens_hsa051340.51907551
122Propanoate metabolism_Homo sapiens_hsa006400.51169461
123GnRH signaling pathway_Homo sapiens_hsa049120.50614840
124Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49765559
125Amoebiasis_Homo sapiens_hsa051460.49555817
126Ether lipid metabolism_Homo sapiens_hsa005650.48219970
127Wnt signaling pathway_Homo sapiens_hsa043100.47500882
128Nucleotide excision repair_Homo sapiens_hsa034200.44825704
129TGF-beta signaling pathway_Homo sapiens_hsa043500.41739323
130Insulin resistance_Homo sapiens_hsa049310.41275936
131Leishmaniasis_Homo sapiens_hsa051400.41263326
132Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41217897
133Prostate cancer_Homo sapiens_hsa052150.40053694
134RNA transport_Homo sapiens_hsa030130.39871140
135Glucagon signaling pathway_Homo sapiens_hsa049220.39294272
136Metabolic pathways_Homo sapiens_hsa011000.38774471
137Pertussis_Homo sapiens_hsa051330.38361481
138Cardiac muscle contraction_Homo sapiens_hsa042600.37440663
139Apoptosis_Homo sapiens_hsa042100.34577073
140Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34278214
141Pathways in cancer_Homo sapiens_hsa052000.34198459
142Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33948422
143Pentose phosphate pathway_Homo sapiens_hsa000300.33909979
144Vibrio cholerae infection_Homo sapiens_hsa051100.32983027
145African trypanosomiasis_Homo sapiens_hsa051430.32565396
146Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.31471783
147ABC transporters_Homo sapiens_hsa020100.31400312
148Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29054471
149Pyruvate metabolism_Homo sapiens_hsa006200.29035633
150Focal adhesion_Homo sapiens_hsa045100.27976620
151Melanoma_Homo sapiens_hsa052180.26547937

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »