FERMT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Kindlins are a small family of proteins that mediate protein-protein interactions involved in integrin activation and thereby have a role in cell adhesion, migration, differentiation, and proliferation. The protein encoded by this gene has a key role in the regulation of hemostasis and thrombosis. This protein may also help maintain the membrane skeleton of erythrocytes. Mutations in this gene cause the autosomal recessive leukocyte adhesion deficiency syndrome-III (LAD-III). Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.42228652
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.13446858
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.13446858
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.92499329
5antigen processing and presentation of endogenous antigen (GO:0019883)4.73499243
6positive regulation of B cell differentiation (GO:0045579)4.58873994
7regulation of B cell receptor signaling pathway (GO:0050855)4.32309513
8ribosomal small subunit assembly (GO:0000028)4.24419707
9regulation of gamma-delta T cell differentiation (GO:0045586)4.03953477
10regulation of mast cell degranulation (GO:0043304)4.00251801
11negative regulation of phagocytosis (GO:0050765)3.94444438
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.90836975
13detection of other organism (GO:0098543)3.87043843
14regulation of B cell differentiation (GO:0045577)3.81629657
15detection of bacterium (GO:0016045)3.80237231
16regulation of gamma-delta T cell activation (GO:0046643)3.76910789
17immunoglobulin mediated immune response (GO:0016064)3.73727364
18granulocyte activation (GO:0036230)3.69368327
19positive regulation of mast cell activation (GO:0033005)3.69345743
20regulation of mast cell activation involved in immune response (GO:0033006)3.68951230
21positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.67203643
22megakaryocyte development (GO:0035855)3.65059858
23B cell receptor signaling pathway (GO:0050853)3.56188997
24Arp2/3 complex-mediated actin nucleation (GO:0034314)3.53885461
25regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.53348030
26leukocyte aggregation (GO:0070486)3.50601118
27antigen processing and presentation via MHC class Ib (GO:0002475)3.50248578
28mast cell activation (GO:0045576)3.49031358
29regulation of mast cell activation (GO:0033003)3.44518838
30regulation of myeloid leukocyte mediated immunity (GO:0002886)3.43213597
31regulation of leukocyte degranulation (GO:0043300)3.43204242
32regulation of interferon-beta biosynthetic process (GO:0045357)3.41890487
33positive regulation by symbiont of host defense response (GO:0052509)3.40634486
34modulation by symbiont of host defense response (GO:0052031)3.40634486
35modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.40634486
36modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.40634486
37positive regulation by organism of defense response of other organism involved in symbiotic interact3.40634486
38modulation by symbiont of host immune response (GO:0052553)3.40634486
39negative regulation of erythrocyte differentiation (GO:0045647)3.37554724
40lipopolysaccharide-mediated signaling pathway (GO:0031663)3.37441981
41neutrophil activation involved in immune response (GO:0002283)3.33974872
42myeloid dendritic cell activation (GO:0001773)3.26077841
43positive regulation of mast cell degranulation (GO:0043306)3.25959517
44positive regulation of mast cell activation involved in immune response (GO:0033008)3.25959517
45response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.24908548
46response to host immune response (GO:0052572)3.24908548
47regulation of erythrocyte differentiation (GO:0045646)3.23360547
48detection of external biotic stimulus (GO:0098581)3.20425793
49T cell homeostasis (GO:0043029)3.17498560
50negative regulation of cell killing (GO:0031342)3.17155521
51negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.17155521
52cellular response to thyroid hormone stimulus (GO:0097067)3.15612005
53viral transcription (GO:0019083)3.14528579
54positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.14170883
55respiratory burst (GO:0045730)3.10428822
56negative regulation of T cell mediated immunity (GO:0002710)3.07987954
57defense response to protozoan (GO:0042832)3.07979095
58definitive hemopoiesis (GO:0060216)3.07934630
59B cell mediated immunity (GO:0019724)3.07676445
60negative regulation of lymphocyte mediated immunity (GO:0002707)3.07089784
61response to peptidoglycan (GO:0032494)3.04545843
62regulation of antigen processing and presentation (GO:0002577)3.01115572
63response to protozoan (GO:0001562)2.99874168
64translational termination (GO:0006415)2.99243751
65microglial cell activation (GO:0001774)2.99201854
66negative regulation of leukocyte mediated immunity (GO:0002704)2.98970253
67regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.98741914
68response to interferon-beta (GO:0035456)2.96585902
69regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.95874808
70macrophage activation (GO:0042116)2.93350652
71response to host (GO:0075136)2.92709134
72response to host defenses (GO:0052200)2.92709134
73response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.92709134
74negative regulation of cytokine production involved in immune response (GO:0002719)2.92519143
75regulation of dendritic cell antigen processing and presentation (GO:0002604)2.89965486
76positive regulation of interferon-alpha production (GO:0032727)2.89848762
77regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.89834186
78positive regulation of granulocyte differentiation (GO:0030854)2.89725161
79regulation of interleukin-2 biosynthetic process (GO:0045076)2.86132229
80myeloid cell activation involved in immune response (GO:0002275)2.85802371
81T cell migration (GO:0072678)2.85665548
82regulation of interleukin-12 biosynthetic process (GO:0045075)2.84471728
83detection of molecule of bacterial origin (GO:0032490)2.83902637
84mast cell degranulation (GO:0043303)2.83626838
85mast cell activation involved in immune response (GO:0002279)2.83626838
86detection of biotic stimulus (GO:0009595)2.83138866
87cellular extravasation (GO:0045123)2.81828545
88cellular response to interferon-beta (GO:0035458)2.79948040
89positive thymic T cell selection (GO:0045059)2.79599734
90lymphocyte homeostasis (GO:0002260)2.78658707
91myeloid dendritic cell differentiation (GO:0043011)2.78624365
92telomere maintenance via semi-conservative replication (GO:0032201)2.78228182
93embryonic hemopoiesis (GO:0035162)2.78212771
94regulation of T cell tolerance induction (GO:0002664)2.77074589
95DNA strand elongation involved in DNA replication (GO:0006271)2.75819792
96pinocytosis (GO:0006907)2.75775980
97response to type I interferon (GO:0034340)2.75695915
98response to muramyl dipeptide (GO:0032495)2.75576878
99regulation of platelet aggregation (GO:0090330)2.75490250
100regulation of interferon-alpha production (GO:0032647)2.74833582
101CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.74688997
102tolerance induction (GO:0002507)2.74156939
103negative regulation of innate immune response (GO:0045824)2.73913771
104positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.73836186
105regulation of regulated secretory pathway (GO:1903305)2.73554149
106leukocyte migration involved in inflammatory response (GO:0002523)2.72732173
107negative regulation of interleukin-12 production (GO:0032695)2.72335333
108myeloid leukocyte activation (GO:0002274)2.72201873
109cellular response to type I interferon (GO:0071357)2.71760724
110type I interferon signaling pathway (GO:0060337)2.71760724
111regulation of alpha-beta T cell proliferation (GO:0046640)2.71212936
112response to interleukin-15 (GO:0070672)2.71150468
113regulation of T-helper 2 cell differentiation (GO:0045628)2.70979127
114mature B cell differentiation (GO:0002335)2.70660837
115positive regulation of antigen processing and presentation (GO:0002579)2.70332191
116mature B cell differentiation involved in immune response (GO:0002313)2.69568027
117positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.68855240
118negative thymic T cell selection (GO:0045060)2.68532340
119regulation of tolerance induction (GO:0002643)2.68119873
120DNA strand elongation (GO:0022616)2.67788804
121negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.66192966
122translational elongation (GO:0006414)2.66127374
123germinal center formation (GO:0002467)2.65538998
124negative T cell selection (GO:0043383)2.65480211
125regulation of natural killer cell mediated immunity (GO:0002715)2.64367794
126granulocyte differentiation (GO:0030851)2.63234410
127interferon-gamma-mediated signaling pathway (GO:0060333)2.62331277
128interferon-gamma production (GO:0032609)2.61955533
129positive regulation of erythrocyte differentiation (GO:0045648)2.61216138
130NIK/NF-kappaB signaling (GO:0038061)2.58595302
131dendritic cell differentiation (GO:0097028)2.58553099
132DNA deamination (GO:0045006)2.58509672
133SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.58420532
134leukocyte degranulation (GO:0043299)2.58079889
135negative regulation of granulocyte differentiation (GO:0030853)2.57214625
1363-UTR-mediated mRNA stabilization (GO:0070935)2.56632869
137regulation of T cell receptor signaling pathway (GO:0050856)2.56445508
138neutrophil activation (GO:0042119)2.56305790
139actin nucleation (GO:0045010)2.56100351
140myeloid cell development (GO:0061515)2.55446940
141regulation of granulocyte differentiation (GO:0030852)2.55264668
142cellular response to zinc ion (GO:0071294)2.53217057
143leukocyte homeostasis (GO:0001776)2.53083302
144macrophage activation involved in immune response (GO:0002281)2.52821359
145cotranslational protein targeting to membrane (GO:0006613)2.50560042
146protein targeting to ER (GO:0045047)2.50213450

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.69249629
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.85215859
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.59202654
4* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.39999871
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.30800792
6SCL_19346495_ChIP-Seq_HPC-7_Human3.22163195
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.12639162
8SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.85519628
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.81184456
10SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.80242466
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.77018065
12* MYC_22102868_ChIP-Seq_BL_Human2.71076585
13VDR_21846776_ChIP-Seq_THP-1_Human2.61379385
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.56451627
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.56129244
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.53320888
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.46673524
18* SPI1_23547873_ChIP-Seq_NB4_Human2.31647006
19* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.30231722
20* IRF8_27001747_Chip-Seq_BMDM_Mouse2.30174574
21FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.27535038
22FOXM1_23109430_ChIP-Seq_U2OS_Human2.23098598
23* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.21253646
24* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.17757597
25STAT4_19710469_ChIP-ChIP_TH1__Mouse2.15632331
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.08309824
27* ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.08076489
28MYB_26560356_Chip-Seq_TH2_Human2.03782241
29Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.99819991
30* MAF_26560356_Chip-Seq_TH1_Human1.97913959
31GATA1_22025678_ChIP-Seq_K562_Human1.97706659
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.96504019
33E2F4_17652178_ChIP-ChIP_JURKAT_Human1.95908871
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.95857086
35* RUNX1_22412390_ChIP-Seq_EML_Mouse1.95828611
36VDR_24763502_ChIP-Seq_THP-1_Human1.93501759
37SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.90213424
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.89638420
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.88797388
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.85341148
41MYB_26560356_Chip-Seq_TH1_Human1.82928043
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.77833960
43KDM2B_26808549_Chip-Seq_SUP-B15_Human1.76842990
44STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.75710727
45* UTX_26944678_Chip-Seq_JUKART_Human1.75077324
46FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.71657158
47MYC_18555785_ChIP-Seq_MESCs_Mouse1.70497858
48ERG_20887958_ChIP-Seq_HPC-7_Mouse1.64454008
49RUNX_20019798_ChIP-Seq_JUKART_Human1.64437246
50* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.63943324
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.63167758
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.62525121
53LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.62191479
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.59810799
55TCF7_22412390_ChIP-Seq_EML_Mouse1.58550770
56CIITA_25753668_ChIP-Seq_RAJI_Human1.58120516
57FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.57617138
58LXR_22292898_ChIP-Seq_THP-1_Human1.57253709
59VDR_24787735_ChIP-Seq_THP-1_Human1.57122514
60SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.57043869
61LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.53534105
62* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.50897467
63* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.50810766
64E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50333117
65VDR_23849224_ChIP-Seq_CD4+_Human1.49831887
66* SPI1_23127762_ChIP-Seq_K562_Human1.42953795
67FOXP3_21729870_ChIP-Seq_TREG_Human1.40769108
68GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.40267902
69EST1_17652178_ChIP-ChIP_JURKAT_Human1.38152531
70PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35805032
71* GATA1_19941827_ChIP-Seq_MEL_Mouse1.33666397
72* MAF_26560356_Chip-Seq_TH2_Human1.33198071
73NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.32099784
74GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31733844
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30676653
76MYC_18358816_ChIP-ChIP_MESCs_Mouse1.30401233
77GABP_17652178_ChIP-ChIP_JURKAT_Human1.28531033
78GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.27155661
79NCOR1_26117541_ChIP-Seq_K562_Human1.26578152
80GATA2_19941826_ChIP-Seq_K562_Human1.25818403
81* BCL6_27268052_Chip-Seq_Bcells_Human1.24604735
82CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20846382
83CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19309955
84ETS1_20019798_ChIP-Seq_JURKAT_Human1.19288086
85E2F1_21310950_ChIP-Seq_MCF-7_Human1.18525803
86GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18007795
87XRN2_22483619_ChIP-Seq_HELA_Human1.17810417
88BCOR_27268052_Chip-Seq_Bcells_Human1.17280800
89IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16385658
90PU_27001747_Chip-Seq_BMDM_Mouse1.16220616
91FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15711993
92CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15208462
93JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.14794707
94GATA3_27048872_Chip-Seq_THYMUS_Human1.12957215
95ELF1_20517297_ChIP-Seq_JURKAT_Human1.12316672
96MYC_19030024_ChIP-ChIP_MESCs_Mouse1.11246749
97* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10563504
98GATA2_21666600_ChIP-Seq_HMVEC_Human1.10129131
99MYC_19079543_ChIP-ChIP_MESCs_Mouse1.09948637
100* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.09149187
101GATA3_26560356_Chip-Seq_TH2_Human1.08313663
102TFEB_21752829_ChIP-Seq_HELA_Human1.05906756
103HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.04956488
104STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04361172
105* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02970866
106CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02762808
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02662160
108* ELK3_25401928_ChIP-Seq_HUVEC_Human1.01772759
109PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00175219
110* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99690088
111RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99004001
112CREB1_15753290_ChIP-ChIP_HEK293T_Human0.98050903
113KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.97634350
114PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97292839
115RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.96968846
116* SPI1_20517297_ChIP-Seq_HL60_Human0.96315770
117CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.95538999
118PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95161395
119GABP_19822575_ChIP-Seq_HepG2_Human0.95028005
120PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94535349
121NELFA_20434984_ChIP-Seq_ESCs_Mouse0.93573309
122DCP1A_22483619_ChIP-Seq_HELA_Human0.92760815
123KDM2B_26808549_Chip-Seq_JURKAT_Human0.92396343
124GATA1_19941826_ChIP-Seq_K562_Human0.90492612
125* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90165567
126KDM2B_26808549_Chip-Seq_DND41_Human0.89976938
127SRF_21415370_ChIP-Seq_HL-1_Mouse0.89711697
128SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89645026
129STAT1_20625510_ChIP-Seq_HELA_Human0.89420849
130SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89417841
131STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.88042375

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.00332733
2MP0002396_abnormal_hematopoietic_system3.33357639
3MP0005671_abnormal_response_to3.11380878
4MP0000685_abnormal_immune_system2.94612276
5MP0003436_decreased_susceptibility_to2.92180884
6MP0001800_abnormal_humoral_immune2.82767217
7MP0009785_altered_susceptibility_to2.76389046
8MP0005000_abnormal_immune_tolerance2.68795236
9MP0002452_abnormal_antigen_presenting2.63965798
10* MP0005464_abnormal_platelet_physiology2.60967384
11MP0005387_immune_system_phenotype2.60802596
12MP0001790_abnormal_immune_system2.60802596
13MP0005025_abnormal_response_to2.57522593
14MP0002419_abnormal_innate_immunity2.55137653
15MP0002398_abnormal_bone_marrow2.53227385
16MP0002420_abnormal_adaptive_immunity2.52759579
17MP0003763_abnormal_thymus_physiology2.52606515
18MP0002723_abnormal_immune_serum2.52575940
19MP0001819_abnormal_immune_cell2.50045565
20MP0002148_abnormal_hypersensitivity_rea2.38793588
21MP0003303_peritoneal_inflammation2.36514555
22MP0001545_abnormal_hematopoietic_system2.34053560
23MP0005397_hematopoietic_system_phenotyp2.34053560
24MP0004808_abnormal_hematopoietic_stem2.24126206
25MP0000689_abnormal_spleen_morphology2.22054195
26MP0000716_abnormal_immune_system2.19162445
27MP0002722_abnormal_immune_system2.13011425
28MP0009333_abnormal_splenocyte_physiolog2.12146849
29MP0006082_CNS_inflammation2.10661243
30MP0002405_respiratory_system_inflammati2.07101844
31MP0003724_increased_susceptibility_to2.02803767
32MP0002166_altered_tumor_susceptibility2.01484004
33MP0005058_abnormal_lysosome_morphology1.99772993
34* MP0002429_abnormal_blood_cell1.96719486
35MP0005174_abnormal_tail_pigmentation1.88273506
36MP0003656_abnormal_erythrocyte_physiolo1.83987829
37MP0001853_heart_inflammation1.82776697
38MP0010155_abnormal_intestine_physiology1.81907527
39MP0000490_abnormal_crypts_of1.81277758
40MP0003172_abnormal_lysosome_physiology1.75953932
41MP0001845_abnormal_inflammatory_respons1.69597987
42MP0003300_gastrointestinal_ulcer1.68771615
43MP0000703_abnormal_thymus_morphology1.68713153
44MP0005075_abnormal_melanosome_morpholog1.63289519
45MP0001873_stomach_inflammation1.62687177
46MP0002006_tumorigenesis1.60382212
47MP0005451_abnormal_body_composition1.58978900
48MP0009278_abnormal_bone_marrow1.56441744
49MP0004947_skin_inflammation1.53456147
50MP0010094_abnormal_chromosome_stability1.53235686
51MP0003693_abnormal_embryo_hatching1.49881287
52MP0003866_abnormal_defecation1.49568025
53* MP0000465_gastrointestinal_hemorrhage1.49208432
54MP0008004_abnormal_stomach_pH1.46698071
55MP0003191_abnormal_cellular_cholesterol1.41336752
56MP0008469_abnormal_protein_level1.40499674
57MP0001533_abnormal_skeleton_physiology1.38360164
58MP0000604_amyloidosis1.35741412
59MP0002132_abnormal_respiratory_system1.32730791
60MP0004510_myositis1.31853858
61MP0008260_abnormal_autophagy1.31321655
62MP0003806_abnormal_nucleotide_metabolis1.30809271
63MP0003077_abnormal_cell_cycle1.28907498
64MP0005310_abnormal_salivary_gland1.27736451
65MP0004147_increased_porphyrin_level1.27717919
66MP0003111_abnormal_nucleus_morphology1.27672495
67MP0008057_abnormal_DNA_replication1.24476846
68MP0002095_abnormal_skin_pigmentation1.22285032
69MP0000015_abnormal_ear_pigmentation1.21103728
70MP0000858_altered_metastatic_potential1.20851410
71MP0010307_abnormal_tumor_latency1.19085484
72MP0005167_abnormal_blood-brain_barrier1.18584776
73MP0002019_abnormal_tumor_incidence1.14267025
74MP0000343_altered_response_to1.12583459
75MP0002933_joint_inflammation1.10930850
76MP0008007_abnormal_cellular_replicative1.10852741
77MP0006054_spinal_hemorrhage1.09650369
78MP0009840_abnormal_foam_cell1.05602307
79MP0008058_abnormal_DNA_repair1.02442111
80MP0003183_abnormal_peptide_metabolism1.01383610
81MP0003448_altered_tumor_morphology0.94208831
82MP0009764_decreased_sensitivity_to0.92135529
83MP0003690_abnormal_glial_cell0.91782218
84MP0000313_abnormal_cell_death0.89195153
85MP0004883_abnormal_blood_vessel0.88382268
86MP0002139_abnormal_hepatobiliary_system0.88148240
87MP0002138_abnormal_hepatobiliary_system0.87663232
88MP0004957_abnormal_blastocyst_morpholog0.86231096
89MP0001851_eye_inflammation0.85827703
90MP0010352_gastrointestinal_tract_polyps0.83546001
91MP0009763_increased_sensitivity_to0.82500171
92MP0003075_altered_response_to0.81372430
93MP0009765_abnormal_xenobiotic_induced0.80801190
94MP0005164_abnormal_response_to0.76869787
95MP0008874_decreased_physiological_sensi0.75045733
96MP0003453_abnormal_keratinocyte_physiol0.72198836
97MP0001663_abnormal_digestive_system0.71662756
98MP0003943_abnormal_hepatobiliary_system0.71409322
99MP0000371_diluted_coat_color0.66357409
100MP0003828_pulmonary_edema0.65613047
101MP0002998_abnormal_bone_remodeling0.65486623
102MP0005166_decreased_susceptibility_to0.65419308
103MP0008873_increased_physiological_sensi0.63266362
104MP0000598_abnormal_liver_morphology0.63094669
105MP0000249_abnormal_blood_vessel0.59465895
106MP0005165_increased_susceptibility_to0.58907040
107MP0003186_abnormal_redox_activity0.57992882
108MP0004381_abnormal_hair_follicle0.56175142
109MP0005381_digestive/alimentary_phenotyp0.56082530
110MP0000609_abnormal_liver_physiology0.54933160
111MP0001986_abnormal_taste_sensitivity0.54107794
112MP0002277_abnormal_respiratory_mucosa0.54094263
113MP0000350_abnormal_cell_proliferation0.54063306
114MP0000477_abnormal_intestine_morphology0.53501354
115MP0003329_amyloid_beta_deposits0.53208897
116MP0000920_abnormal_myelination0.53114933
117MP0005319_abnormal_enzyme/_coenzyme0.52540632
118MP0002877_abnormal_melanocyte_morpholog0.52044138
119MP0003091_abnormal_cell_migration0.51912027
120MP0005023_abnormal_wound_healing0.51164142
121MP0005390_skeleton_phenotype0.50824895
122MP0003566_abnormal_cell_adhesion0.50249172
123* MP0003795_abnormal_bone_structure0.49991048
124MP0005535_abnormal_body_temperature0.48053407

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.25715691
2Recurrent bacterial skin infections (HP:0005406)4.61199698
3Chronic otitis media (HP:0000389)4.34672270
4Abnormality of liposaccharide metabolism (HP:0010968)4.33349020
5Abnormality of glycosphingolipid metabolism (HP:0004343)4.33349020
6Abnormality of glycolipid metabolism (HP:0010969)4.33349020
7IgM deficiency (HP:0002850)4.32493803
8Eczematoid dermatitis (HP:0000976)4.27454753
9Prolonged bleeding time (HP:0003010)4.22284482
10Elevated erythrocyte sedimentation rate (HP:0003565)4.14176083
11* Petechiae (HP:0000967)4.02849408
12Recurrent viral infections (HP:0004429)4.01671136
13Thrombocytosis (HP:0001894)4.00505271
14Recurrent fungal infections (HP:0002841)3.78698989
15Myositis (HP:0100614)3.78590343
16Panhypogammaglobulinemia (HP:0003139)3.61205044
17Abnormal delayed hypersensitivity skin test (HP:0002963)3.51118891
18Cellulitis (HP:0100658)3.47133562
19Meningitis (HP:0001287)3.34262872
20Recurrent skin infections (HP:0001581)3.33352038
21Recurrent bronchitis (HP:0002837)3.26538230
22Abnormal number of erythroid precursors (HP:0012131)3.21165646
23Mediastinal lymphadenopathy (HP:0100721)3.19612935
24Impaired platelet aggregation (HP:0003540)3.19392418
25Abnormal platelet function (HP:0011869)3.19392418
26Abnormality of macrophages (HP:0004311)3.17242096
27Abnormality of cells of the erythroid lineage (HP:0012130)3.14503394
28Abnormality of T cell physiology (HP:0011840)3.11696843
29Recurrent gram-negative bacterial infections (HP:0005420)3.11262438
30* Epistaxis (HP:0000421)3.09267907
31Agammaglobulinemia (HP:0004432)3.09091454
32Recurrent cutaneous fungal infections (HP:0011370)3.04686169
33Chronic mucocutaneous candidiasis (HP:0002728)3.04686169
34Abnormality of the heme biosynthetic pathway (HP:0010472)3.03311466
35Increased mean platelet volume (HP:0011877)3.02174928
36Inflammation of the large intestine (HP:0002037)3.01951421
37Obstructive lung disease (HP:0006536)3.01543834
38Chronic obstructive pulmonary disease (HP:0006510)3.01543834
39Gastrointestinal inflammation (HP:0004386)3.00604546
40Abnormality of T cells (HP:0002843)2.99421799
41Pustule (HP:0200039)2.93426253
42Increased serum ferritin (HP:0003281)2.93324244
43Vacuolated lymphocytes (HP:0001922)2.89791066
44Loss of speech (HP:0002371)2.87254512
45Nasal polyposis (HP:0100582)2.86225154
46Hepatosplenomegaly (HP:0001433)2.80888034
47Spontaneous hematomas (HP:0007420)2.78890310
48Vasculitis (HP:0002633)2.73950212
49Aplastic anemia (HP:0001915)2.72231288
50Increased neuronal autofluorescent lipopigment (HP:0002074)2.70924204
51Increased cerebral lipofuscin (HP:0011813)2.69957271
52Purpura (HP:0000979)2.69335757
53Systemic lupus erythematosus (HP:0002725)2.69053039
54Lymphopenia (HP:0001888)2.68766998
55Increased IgM level (HP:0003496)2.67376429
56Abnormality of the nasal mucosa (HP:0000433)2.65638020
57Colitis (HP:0002583)2.63518928
58Agnosia (HP:0010524)2.63200364
59Abnormality of cells of the lymphoid lineage (HP:0012140)2.62499642
60Gastrointestinal infarctions (HP:0005244)2.61601121
61Abnormality of iron homeostasis (HP:0011031)2.61272694
62Reticulocytopenia (HP:0001896)2.60187543
63T lymphocytopenia (HP:0005403)2.59223529
64Autoimmune thrombocytopenia (HP:0001973)2.56530227
65Abnormality of the prostate (HP:0008775)2.56097276
66Gingival bleeding (HP:0000225)2.54792904
67Orchitis (HP:0100796)2.52304011
68B lymphocytopenia (HP:0010976)2.50334946
69Abnormality of B cell number (HP:0010975)2.50334946
70Disinhibition (HP:0000734)2.49731363
71Periodontitis (HP:0000704)2.49277913
72Abnormality of T cell number (HP:0011839)2.48990556
73Gastrointestinal stroma tumor (HP:0100723)2.47711467
74Abnormal platelet volume (HP:0011876)2.45888841
75Hemoptysis (HP:0002105)2.44600586
76Keratoconjunctivitis sicca (HP:0001097)2.42772622
77Encephalitis (HP:0002383)2.40667096
78Lymphoma (HP:0002665)2.40542375
79Granulocytopenia (HP:0001913)2.39229335
80Osteomyelitis (HP:0002754)2.37671985
81Stomatitis (HP:0010280)2.37418023
82Hypertensive crisis (HP:0100735)2.36572805
83IgG deficiency (HP:0004315)2.36308062
84Thyroiditis (HP:0100646)2.33323709
85Retrobulbar optic neuritis (HP:0100654)2.31231958
86Optic neuritis (HP:0100653)2.31231958
87Interstitial pulmonary disease (HP:0006530)2.28232505
88Episodic fever (HP:0001954)2.27470577
89Autoimmune hemolytic anemia (HP:0001890)2.26219347
90Dysostosis multiplex (HP:0000943)2.25263033
91Eosinophilia (HP:0001880)2.24977375
92Pallor (HP:0000980)2.24807094
93Keratoconjunctivitis (HP:0001096)2.20010895
94Severe combined immunodeficiency (HP:0004430)2.19991017
95Abnormality of the vasculature of the conjunctiva (HP:0008054)2.18859215
96Hypergammaglobulinemia (HP:0010702)2.17872930
97Abnormality of transition element cation homeostasis (HP:0011030)2.17477568
98Abnormality of eosinophils (HP:0001879)2.16291152
99Combined immunodeficiency (HP:0005387)2.15107077
100Amyloidosis (HP:0011034)2.14724786
101Gingivitis (HP:0000230)2.13076155
102Abnormality of polysaccharide metabolism (HP:0011012)2.12908072
103Abnormality of glycosaminoglycan metabolism (HP:0004371)2.12908072
104Abnormality of mucopolysaccharide metabolism (HP:0011020)2.12908072
105Urticaria (HP:0001025)2.11518441
106Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.10445376
107* Leukocytosis (HP:0001974)2.10369122
108Pulmonary embolism (HP:0002204)2.09736460
109Myelodysplasia (HP:0002863)2.08545970
110Increased IgE level (HP:0003212)2.07021719
111Papilloma (HP:0012740)2.05981607
112Verrucae (HP:0200043)2.05981607
113Hematochezia (HP:0002573)2.05567971
114Pulmonary infiltrates (HP:0002113)2.04256134
115Arterial thrombosis (HP:0004420)2.04245962
116Chest pain (HP:0100749)2.03868711
117Thoracic kyphosis (HP:0002942)2.03531792
118Mutism (HP:0002300)2.02931447
119Amaurosis fugax (HP:0100576)2.02194778
120Poikiloderma (HP:0001029)2.02050946
121Polycythemia (HP:0001901)2.00103428
122Urinary glycosaminoglycan excretion (HP:0003541)1.99845980
123Mucopolysacchariduria (HP:0008155)1.99845980
124Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.99483913
125Albinism (HP:0001022)1.98807771
126Abnormality of the fingertips (HP:0001211)1.97486434
127Neutropenia (HP:0001875)1.96875936
128Polyneuropathy (HP:0001271)1.96863334
129Chronic sinusitis (HP:0011109)1.96604265
130Recurrent pneumonia (HP:0006532)1.95947742
131Recurrent lower respiratory tract infections (HP:0002783)1.95429236
132Menorrhagia (HP:0000132)1.94539804
133Sepsis (HP:0100806)1.92493032

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.61341660
2KIT2.87929522
3BLK2.75327707
4PRPF4B2.53286929
5TXK2.46385971
6EEF2K2.35471942
7BTK2.34754884
8ZAP702.30739396
9TYK22.23440867
10IRAK42.18792785
11JAK32.17170088
12TBK12.11253455
13STK102.07371359
14TEC2.02260264
15CSF1R2.00732743
16NME21.91391727
17SYK1.89634567
18TGFBR21.83242869
19MAP2K31.80999041
20TAOK31.78786874
21MAP3K141.76766979
22FGR1.76566525
23IKBKE1.74552852
24TAOK21.64927290
25CLK11.58785211
26TAOK11.56635942
27IKBKB1.52249004
28MAP3K31.51709458
29GRK61.48043759
30PIM21.47656490
31PKN21.47651346
32FLT31.43878944
33RIPK41.43766269
34ERN11.39499102
35FES1.35918209
36MAP3K101.35606142
37LCK1.34794478
38LYN1.29172529
39ITK1.27605936
40LRRK21.27382893
41PIM11.23439973
42HCK1.23298829
43IRAK31.18897857
44MAP3K11.15458379
45TGFBR11.11273488
46STK161.10608886
47BMPR21.10390595
48SIK31.10135678
49SCYL21.09642467
50MATK1.08153100
51CDC71.07948448
52NEK21.06511691
53JAK11.04612115
54RPS6KA41.00378328
55GRK70.98324359
56TRIB30.98137620
57EIF2AK10.97290533
58STK40.94404001
59WEE10.93367129
60KDR0.91235855
61CSK0.90263299
62ACVR1B0.88888409
63CDC42BPA0.85086536
64BMX0.84819666
65RPS6KB20.83441781
66VRK10.81666466
67JAK20.80630198
68CDK40.76376270
69CCNB10.75793818
70MAPK120.74622954
71SIK20.70827264
72CHUK0.70522936
73MAP3K60.70460767
74TESK20.68659862
75CAMKK20.68108611
76TNK20.67424887
77ATR0.66459314
78PRKCQ0.66195116
79BUB10.65503158
80MAP3K130.64293532
81RPS6KA60.63169333
82IRAK10.62596180
83NEK90.62404019
84PDPK10.61497316
85MAP3K110.61479811
86MAP3K50.60674453
87PASK0.59321795
88MAPK40.57959755
89MARK20.56145503
90BRSK20.55333157
91MARK30.54744029
92PAK40.54563455
93MAP3K80.54431907
94RPS6KC10.52518986
95RPS6KL10.52518986
96MAP3K120.52426728
97IRAK20.52066446
98KSR20.50432516
99TSSK60.49786311
100FYN0.49722716
101SMG10.49234120
102CDK60.49180715
103EPHB10.48922072
104MKNK10.48393491
105TRPM70.48327935
106DYRK30.48025042
107MAPK70.47767400
108MAPK110.47667651
109CDK190.45777097
110ARAF0.44828671
111MAPKAPK50.44757734
112NLK0.44355482
113FGFR40.44160447
114MAPKAPK20.43441183
115DDR20.42867804
116CDK70.42589469
117MST40.40420208
118PRKD20.40417752
119FGFR30.40045467
120MOS0.39486362
121EIF2AK30.39139265
122YES10.38805191
123MAP2K60.38476220
124BCKDK0.37886915
125PTK2B0.35378075
126PDK10.35266458
127TLK10.34630859
128HIPK20.34611038
129PIK3CG0.33932078
130CAMKK10.33644659
131RAF10.33307594
132AURKB0.32402789
133ABL10.31574611
134DAPK20.29799366
135RPS6KA20.29386879
136PRKCD0.29260084
137ABL20.28436735

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.15550674
2Primary immunodeficiency_Homo sapiens_hsa053403.13887694
3Leishmaniasis_Homo sapiens_hsa051402.63650481
4Ribosome_Homo sapiens_hsa030102.35226911
5B cell receptor signaling pathway_Homo sapiens_hsa046622.33398391
6Mismatch repair_Homo sapiens_hsa034302.21499602
7Antigen processing and presentation_Homo sapiens_hsa046122.12903492
8Hematopoietic cell lineage_Homo sapiens_hsa046402.09841556
9Base excision repair_Homo sapiens_hsa034102.09404796
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.07233333
11Measles_Homo sapiens_hsa051622.07115019
12Type I diabetes mellitus_Homo sapiens_hsa049402.00532524
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.99432637
14Other glycan degradation_Homo sapiens_hsa005111.96174191
15Osteoclast differentiation_Homo sapiens_hsa043801.95966292
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.89770298
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.81802806
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.78429163
19Staphylococcus aureus infection_Homo sapiens_hsa051501.74699223
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.65281269
21Herpes simplex infection_Homo sapiens_hsa051681.65280493
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.64691819
23Legionellosis_Homo sapiens_hsa051341.60116970
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.57163278
25Homologous recombination_Homo sapiens_hsa034401.55615816
26Pertussis_Homo sapiens_hsa051331.49625946
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.47531685
28Shigellosis_Homo sapiens_hsa051311.42320040
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.40881783
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.38267244
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.37007560
32Tuberculosis_Homo sapiens_hsa051521.35620938
33Spliceosome_Homo sapiens_hsa030401.34163479
34T cell receptor signaling pathway_Homo sapiens_hsa046601.33612457
35Non-homologous end-joining_Homo sapiens_hsa034501.29472225
36Apoptosis_Homo sapiens_hsa042101.28571011
37Acute myeloid leukemia_Homo sapiens_hsa052211.28356248
38Malaria_Homo sapiens_hsa051441.26647743
39Influenza A_Homo sapiens_hsa051641.25912849
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.24163864
41Nucleotide excision repair_Homo sapiens_hsa034201.23772581
42Toxoplasmosis_Homo sapiens_hsa051451.23604741
43Hepatitis B_Homo sapiens_hsa051611.21511761
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.17988322
45Allograft rejection_Homo sapiens_hsa053301.17064206
46Lysosome_Homo sapiens_hsa041421.15266043
47Asthma_Homo sapiens_hsa053101.13917643
48* Platelet activation_Homo sapiens_hsa046111.11439500
49Chronic myeloid leukemia_Homo sapiens_hsa052201.07571243
50Graft-versus-host disease_Homo sapiens_hsa053321.03580041
51Chemokine signaling pathway_Homo sapiens_hsa040621.02064142
52One carbon pool by folate_Homo sapiens_hsa006701.00661204
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00284705
54Epstein-Barr virus infection_Homo sapiens_hsa051691.00075598
55Cell cycle_Homo sapiens_hsa041100.98566190
56Pyrimidine metabolism_Homo sapiens_hsa002400.98322639
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97948984
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94754457
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94224069
60Fanconi anemia pathway_Homo sapiens_hsa034600.92647206
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91323109
62Salmonella infection_Homo sapiens_hsa051320.91288093
63Leukocyte transendothelial migration_Homo sapiens_hsa046700.91066688
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86255387
65p53 signaling pathway_Homo sapiens_hsa041150.86093310
66TNF signaling pathway_Homo sapiens_hsa046680.85038692
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.84742034
68Viral carcinogenesis_Homo sapiens_hsa052030.83722534
69Collecting duct acid secretion_Homo sapiens_hsa049660.81226122
70Pentose phosphate pathway_Homo sapiens_hsa000300.80668650
71Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.80346295
72Viral myocarditis_Homo sapiens_hsa054160.78218089
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77407065
74Proteasome_Homo sapiens_hsa030500.76916345
75Pancreatic cancer_Homo sapiens_hsa052120.76356438
76N-Glycan biosynthesis_Homo sapiens_hsa005100.75848674
77RNA degradation_Homo sapiens_hsa030180.73034929
78Systemic lupus erythematosus_Homo sapiens_hsa053220.70252082
79HTLV-I infection_Homo sapiens_hsa051660.68695701
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68512306
81RNA transport_Homo sapiens_hsa030130.66384203
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63529505
83RNA polymerase_Homo sapiens_hsa030200.62728659
84Hepatitis C_Homo sapiens_hsa051600.62531320
85Non-small cell lung cancer_Homo sapiens_hsa052230.61611247
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61573354
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.60926721
88Endocytosis_Homo sapiens_hsa041440.60100746
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57873939
90Amoebiasis_Homo sapiens_hsa051460.57107478
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.56999093
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.56869278
93Caffeine metabolism_Homo sapiens_hsa002320.56025571
94Small cell lung cancer_Homo sapiens_hsa052220.55823604
95Bladder cancer_Homo sapiens_hsa052190.54040956
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52783183
97Phagosome_Homo sapiens_hsa041450.52550847
98Sulfur relay system_Homo sapiens_hsa041220.48391574
99Rheumatoid arthritis_Homo sapiens_hsa053230.45692624
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.45456935
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44724816
102Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.44497141
103Autoimmune thyroid disease_Homo sapiens_hsa053200.42314297
104Colorectal cancer_Homo sapiens_hsa052100.41839845
105Prolactin signaling pathway_Homo sapiens_hsa049170.41129623
106Renal cell carcinoma_Homo sapiens_hsa052110.40563345
107VEGF signaling pathway_Homo sapiens_hsa043700.38646654
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37857627
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37756283
110Notch signaling pathway_Homo sapiens_hsa043300.37050887
111Prion diseases_Homo sapiens_hsa050200.36715133
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36240910
113HIF-1 signaling pathway_Homo sapiens_hsa040660.34549960
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34098880
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33573130
116African trypanosomiasis_Homo sapiens_hsa051430.32860970
117GnRH signaling pathway_Homo sapiens_hsa049120.29345403
118MAPK signaling pathway_Homo sapiens_hsa040100.25047472
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.23851169
120mTOR signaling pathway_Homo sapiens_hsa041500.23086322
121Arachidonic acid metabolism_Homo sapiens_hsa005900.22878561
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.22866289
123Type II diabetes mellitus_Homo sapiens_hsa049300.22845206
124Complement and coagulation cascades_Homo sapiens_hsa046100.20600143
125Choline metabolism in cancer_Homo sapiens_hsa052310.19877905
126Insulin resistance_Homo sapiens_hsa049310.18886344

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