FERP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule catabolic process (GO:0016998)7.37221042
2cell wall macromolecule metabolic process (GO:0044036)6.03159033
3replication fork processing (GO:0031297)5.64558688
4heparin metabolic process (GO:0030202)5.04398868
5heparin biosynthetic process (GO:0030210)5.04398868
6DNA double-strand break processing (GO:0000729)4.64852669
7DNA strand renaturation (GO:0000733)4.59813761
8proteasome assembly (GO:0043248)4.36372184
9negative regulation of DNA-dependent DNA replication (GO:2000104)4.31450378
10viral mRNA export from host cell nucleus (GO:0046784)4.20371124
11protein K6-linked ubiquitination (GO:0085020)4.12143588
12maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.08044873
13rRNA methylation (GO:0031167)4.04324277
14positive regulation of cell cycle G2/M phase transition (GO:1902751)3.92220331
15positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)3.92220331
16histone H2A ubiquitination (GO:0033522)3.76179535
17postreplication repair (GO:0006301)3.75732518
18resolution of meiotic recombination intermediates (GO:0000712)3.71903259
19rRNA modification (GO:0000154)3.69671390
20kinetochore organization (GO:0051383)3.66012977
21transcription from mitochondrial promoter (GO:0006390)3.63876257
22sympathetic nervous system development (GO:0048485)3.62219017
23protein localization to microtubule cytoskeleton (GO:0072698)3.60956205
24cellular response to nicotine (GO:0071316)3.60289123
25kinetochore assembly (GO:0051382)3.59499095
26myelin assembly (GO:0032288)3.50456929
27N-terminal protein amino acid acetylation (GO:0006474)3.49298438
28regulation of spindle organization (GO:0090224)3.45108789
29negative regulation of DNA repair (GO:0045738)3.40069676
30histone H2A monoubiquitination (GO:0035518)3.35801855
31DNA catabolic process, exonucleolytic (GO:0000738)3.34824886
32regulation of centriole replication (GO:0046599)3.33290627
33DNA topological change (GO:0006265)3.31217755
34double-strand break repair via homologous recombination (GO:0000724)3.30556820
35sister chromatid segregation (GO:0000819)3.30515957
36ribosome assembly (GO:0042255)3.28104119
37recombinational repair (GO:0000725)3.25034631
38negative regulation of thymocyte apoptotic process (GO:0070244)3.24442735
39protein localization to cilium (GO:0061512)3.22369554
40cellular response to interleukin-15 (GO:0071350)3.19693249
41microtubule anchoring (GO:0034453)3.19607539
42DNA ligation (GO:0006266)3.16914136
43ganglion development (GO:0061548)3.09610511
44poly(A)+ mRNA export from nucleus (GO:0016973)3.08185001
45translesion synthesis (GO:0019985)3.08056281
46epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.03058566
47chromatin remodeling at centromere (GO:0031055)3.01869365
48mitotic recombination (GO:0006312)3.01783211
49mitochondrial RNA metabolic process (GO:0000959)2.99858189
50positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)2.98471933
51regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.98181137
52regulation of mitotic spindle checkpoint (GO:1903504)2.98181137
53telomere maintenance via semi-conservative replication (GO:0032201)2.97880241
54DNA integration (GO:0015074)2.97482690
55protein localization to cytoskeleton (GO:0044380)2.95788493
56monoubiquitinated protein deubiquitination (GO:0035520)2.94589615
57positive regulation of macrophage activation (GO:0043032)2.94184245
58mitotic sister chromatid segregation (GO:0000070)2.94157794
59negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.94025377
60negative regulation of translation, ncRNA-mediated (GO:0040033)2.94025377
61regulation of translation, ncRNA-mediated (GO:0045974)2.94025377
62pore complex assembly (GO:0046931)2.91330069
63regulation of mitotic spindle organization (GO:0060236)2.90213206
64mitotic spindle checkpoint (GO:0071174)2.89899445
65nuclear pore complex assembly (GO:0051292)2.89615031
66thrombin receptor signaling pathway (GO:0070493)2.89482506
67purine nucleobase biosynthetic process (GO:0009113)2.89357728
68telomere maintenance via recombination (GO:0000722)2.88355397
69somatic hypermutation of immunoglobulin genes (GO:0016446)2.88155063
70somatic diversification of immune receptors via somatic mutation (GO:0002566)2.88155063
71spindle checkpoint (GO:0031577)2.86990578
72CENP-A containing nucleosome assembly (GO:0034080)2.85748117
73DNA strand elongation involved in DNA replication (GO:0006271)2.85156220
74retinal cone cell development (GO:0046549)2.83545307
75negative regulation of DNA recombination (GO:0045910)2.81753587
76nucleotide-excision repair, DNA gap filling (GO:0006297)2.81723579
77DNA strand elongation (GO:0022616)2.81510799
78nucleobase biosynthetic process (GO:0046112)2.77050092
79regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.76799022
80negative regulation of transcription regulatory region DNA binding (GO:2000678)2.74322397
81tachykinin receptor signaling pathway (GO:0007217)2.72903400
82kidney morphogenesis (GO:0060993)2.70590619
83cartilage morphogenesis (GO:0060536)2.66946442
84positive regulation of steroid hormone secretion (GO:2000833)2.66290169
85mitotic sister chromatid cohesion (GO:0007064)2.65745643
86RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.65577644
87negative regulation of mitotic sister chromatid separation (GO:2000816)2.65564236
88negative regulation of sister chromatid segregation (GO:0033046)2.65564236
89negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.65564236
90negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.65564236
91negative regulation of mitotic sister chromatid segregation (GO:0033048)2.65564236
92regulation of timing of cell differentiation (GO:0048505)2.61519294
93regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.61119357
94histone exchange (GO:0043486)2.61007831
95nonmotile primary cilium assembly (GO:0035058)2.60647633
96positive regulation of alpha-beta T cell proliferation (GO:0046641)2.59780894
97dopaminergic neuron differentiation (GO:0071542)2.59386259
98negative regulation of chromosome segregation (GO:0051985)2.59153667
99protein prenylation (GO:0018342)2.59148890
100prenylation (GO:0097354)2.59148890

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.37246620
2RBPJ_22232070_ChIP-Seq_NCS_Mouse5.11137722
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.63022837
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.10455782
5ELK1_19687146_ChIP-ChIP_HELA_Human2.95486026
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.84731263
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.78187016
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.77674481
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.59369010
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.45710574
11EWS_26573619_Chip-Seq_HEK293_Human2.44911285
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.32650128
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.23232035
14IGF1R_20145208_ChIP-Seq_DFB_Human2.22493173
15ZNF274_21170338_ChIP-Seq_K562_Hela2.11728151
16FUS_26573619_Chip-Seq_HEK293_Human2.09715402
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.03842962
18GBX2_23144817_ChIP-Seq_PC3_Human2.00470420
19KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.99080239
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.94463115
21RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93697861
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.83892892
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.82443954
24VDR_22108803_ChIP-Seq_LS180_Human1.81992962
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.78784907
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.76302598
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68753641
28P300_19829295_ChIP-Seq_ESCs_Human1.67040439
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.62120240
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55780483
31PADI4_21655091_ChIP-ChIP_MCF-7_Human1.54098714
32BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.52387501
33VDR_23849224_ChIP-Seq_CD4+_Human1.52112473
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51996776
35HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50777210
36AR_21909140_ChIP-Seq_LNCAP_Human1.49673780
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.47192161
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.42477740
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40655267
40EZH2_27294783_Chip-Seq_NPCs_Mouse1.39776809
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.37740962
42AR_21572438_ChIP-Seq_LNCaP_Human1.37514360
43POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35148649
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.33464454
45CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.31529671
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30667582
47TAF15_26573619_Chip-Seq_HEK293_Human1.30661142
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24636397
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24389196
50MYC_18940864_ChIP-ChIP_HL60_Human1.24292660
51FOXP3_21729870_ChIP-Seq_TREG_Human1.24103953
52ER_23166858_ChIP-Seq_MCF-7_Human1.21710396
53CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20634600
54SALL4_22934838_ChIP-ChIP_CD34+_Human1.20376126
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.18100180
56CRX_20693478_ChIP-Seq_RETINA_Mouse1.15959428
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15921042
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15670616
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.13898352
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13489959
61CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.10986882
62TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10850053
63SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.09662888
64SMAD4_21799915_ChIP-Seq_A2780_Human1.09218116
65MYC_18555785_ChIP-Seq_MESCs_Mouse1.08627577
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07817313
67WT1_19549856_ChIP-ChIP_CCG9911_Human1.07458463
68MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.05950327
69STAT3_23295773_ChIP-Seq_U87_Human1.05127348
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04986010
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03226421
72OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02837614
73TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.01669466
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01425841
75BCAT_22108803_ChIP-Seq_LS180_Human1.01306884
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00760209
77TCF4_22108803_ChIP-Seq_LS180_Human0.99795707
78E2F1_18555785_Chip-Seq_ESCs_Mouse0.99268322
79POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99171978
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99171978
81NANOG_18555785_Chip-Seq_ESCs_Mouse0.98195053
82CDX2_22108803_ChIP-Seq_LS180_Human0.97602443
83P53_22387025_ChIP-Seq_ESCs_Mouse0.97366473
84CBP_20019798_ChIP-Seq_JUKART_Human0.95661030
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95661030
86SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.94573485
87IRF1_19129219_ChIP-ChIP_H3396_Human0.94362334
88ETS1_20019798_ChIP-Seq_JURKAT_Human0.93298291
89SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92304748
90RUNX2_22187159_ChIP-Seq_PCA_Human0.91741817
91TCF4_23295773_ChIP-Seq_U87_Human0.90095115
92PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.89154123
93JUN_21703547_ChIP-Seq_K562_Human0.88652188
94RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.88608501
95CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.87375378
96CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.86988267
97TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86131601
98P300_18555785_Chip-Seq_ESCs_Mouse0.86040896
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85850001
100TP53_22573176_ChIP-Seq_HFKS_Human0.85828969

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009697_abnormal_copulation5.45335682
2MP0000566_synostosis3.79179681
3MP0010094_abnormal_chromosome_stability3.50750078
4MP0008057_abnormal_DNA_replication3.42113876
5MP0006292_abnormal_olfactory_placode3.01250104
6MP0010386_abnormal_urinary_bladder2.68113190
7MP0010307_abnormal_tumor_latency2.61708953
8MP0003111_abnormal_nucleus_morphology2.56893301
9MP0002938_white_spotting2.43888296
10MP0004147_increased_porphyrin_level2.31423698
11MP0005084_abnormal_gallbladder_morpholo2.27531105
12MP0002282_abnormal_trachea_morphology2.17008192
13MP0000372_irregular_coat_pigmentation2.13731030
14MP0000427_abnormal_hair_cycle2.10580542
15MP0008789_abnormal_olfactory_epithelium2.04390369
16MP0002102_abnormal_ear_morphology2.02503559
17MP0008058_abnormal_DNA_repair2.02341690
18MP0008877_abnormal_DNA_methylation1.99314605
19MP0004957_abnormal_blastocyst_morpholog1.96216819
20MP0003806_abnormal_nucleotide_metabolis1.88506780
21MP0001986_abnormal_taste_sensitivity1.82134199
22MP0001727_abnormal_embryo_implantation1.78836706
23MP0003077_abnormal_cell_cycle1.77461916
24MP0003937_abnormal_limbs/digits/tail_de1.70934421
25MP0010030_abnormal_orbit_morphology1.70525421
26MP0001501_abnormal_sleep_pattern1.69670804
27MP0003718_maternal_effect1.59860086
28MP0005551_abnormal_eye_electrophysiolog1.54069418
29MP0008007_abnormal_cellular_replicative1.51718748
30MP0003693_abnormal_embryo_hatching1.43754901
31MP0002751_abnormal_autonomic_nervous1.43632512
32MP0000569_abnormal_digit_pigmentation1.40296002
33MP0005408_hypopigmentation1.38709300
34MP0000631_abnormal_neuroendocrine_gland1.37780212
35MP0009250_abnormal_appendicular_skeleto1.27659456
36MP0002095_abnormal_skin_pigmentation1.27337872
37MP0002638_abnormal_pupillary_reflex1.27035812
38MP0003880_abnormal_central_pattern1.24882032
39MP0000647_abnormal_sebaceous_gland1.24818639
40MP0003786_premature_aging1.24451605
41MP0001177_atelectasis1.22561291
42MP0000428_abnormal_craniofacial_morphol1.21164808
43MP0005499_abnormal_olfactory_system1.18336616
44MP0005394_taste/olfaction_phenotype1.18336616
45MP0003938_abnormal_ear_development1.17944555
46MP0006054_spinal_hemorrhage1.16600219
47MP0005220_abnormal_exocrine_pancreas1.13808073
48MP0001293_anophthalmia1.13806606
49MP0003011_delayed_dark_adaptation1.13303655
50MP0002876_abnormal_thyroid_physiology1.10713629
51MP0003252_abnormal_bile_duct1.10334259
52MP0009053_abnormal_anal_canal1.09986422
53MP0001929_abnormal_gametogenesis1.06818181
54MP0002396_abnormal_hematopoietic_system1.06055635
55MP0001188_hyperpigmentation1.03293622
56MP0001346_abnormal_lacrimal_gland1.03189777
57MP0006035_abnormal_mitochondrial_morpho1.02194883
58MP0000627_abnormal_mammary_gland1.01149900
59MP0001119_abnormal_female_reproductive1.00793768
60MP0001697_abnormal_embryo_size1.00198528
61MP0000653_abnormal_sex_gland0.99393604
62MP0002138_abnormal_hepatobiliary_system0.98888227
63MP0000015_abnormal_ear_pigmentation0.97545128
64MP0005395_other_phenotype0.96842447
65MP0001243_abnormal_dermal_layer0.96056890
66MP0005075_abnormal_melanosome_morpholog0.95241125
67MP0001186_pigmentation_phenotype0.90781350
68MP0000377_abnormal_hair_follicle0.89731228
69MP0003567_abnormal_fetal_cardiomyocyte0.88843657
70MP0002210_abnormal_sex_determination0.87169785
71MP0008932_abnormal_embryonic_tissue0.86987706
72MP0002234_abnormal_pharynx_morphology0.86963057
73MP0002088_abnormal_embryonic_growth/wei0.85906625
74MP0001324_abnormal_eye_pigmentation0.82984744
75MP0005266_abnormal_metabolism0.82420928
76MP0003385_abnormal_body_wall0.81372281
77MP0000383_abnormal_hair_follicle0.81143048
78MP0001145_abnormal_male_reproductive0.80831282
79MP0003936_abnormal_reproductive_system0.80647730
80MP0002075_abnormal_coat/hair_pigmentati0.78480164
81MP0004215_abnormal_myocardial_fiber0.77558514
82MP0002127_abnormal_cardiovascular_syste0.77064396
83MP0005646_abnormal_pituitary_gland0.76800998
84MP0003984_embryonic_growth_retardation0.74123862
85MP0005248_abnormal_Harderian_gland0.73547578
86MP0001879_abnormal_lymphatic_vessel0.73206926
87MP0002233_abnormal_nose_morphology0.72842626
88MP0005380_embryogenesis_phenotype0.72557461
89MP0001672_abnormal_embryogenesis/_devel0.72557461
90MP0001286_abnormal_eye_development0.72075606
91MP0003943_abnormal_hepatobiliary_system0.71946490
92MP0002177_abnormal_outer_ear0.71900417
93MP0010678_abnormal_skin_adnexa0.71710150
94MP0003698_abnormal_male_reproductive0.71132062
95MP0003755_abnormal_palate_morphology0.70846345
96MP0003935_abnormal_craniofacial_develop0.70760570
97MP0003121_genomic_imprinting0.70617955
98MP0002111_abnormal_tail_morphology0.70125412
99MP0000778_abnormal_nervous_system0.69473087
100MP0000350_abnormal_cell_proliferation0.68459340

Predicted human phenotypes

RankGene SetZ-score
1Concave nail (HP:0001598)4.31514559
2Pancreatic cysts (HP:0001737)3.43934049
3Abnormality of midbrain morphology (HP:0002418)3.40441763
4Molar tooth sign on MRI (HP:0002419)3.40441763
5Amyotrophic lateral sclerosis (HP:0007354)3.23433348
6Volvulus (HP:0002580)3.18509461
7Glioma (HP:0009733)2.98257478
8Pancreatic islet-cell hyperplasia (HP:0004510)2.95211799
9Congenital, generalized hypertrichosis (HP:0004540)2.94537837
10Abnormality of chromosome stability (HP:0003220)2.93619573
11Aplasia/Hypoplasia of the uvula (HP:0010293)2.80121778
12Neuroblastic tumors (HP:0004376)2.74591877
13Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.74591877
14Neuroblastoma (HP:0003006)2.74591877
15Primitive neuroectodermal tumor (HP:0030065)2.74591877
16Meckel diverticulum (HP:0002245)2.72077199
17Birth length less than 3rd percentile (HP:0003561)2.71359067
18True hermaphroditism (HP:0010459)2.69305081
19Pancreatic fibrosis (HP:0100732)2.65929715
20Abnormality of the ileum (HP:0001549)2.65690432
21Chromsome breakage (HP:0040012)2.65254201
22Renal hypoplasia (HP:0000089)2.63544149
23Short 4th metacarpal (HP:0010044)2.62461254
24Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.62461254
25Chromosomal breakage induced by crosslinking agents (HP:0003221)2.62400770
26Aplasia/Hypoplasia of the tongue (HP:0010295)2.60827361
27Abnormality of the renal cortex (HP:0011035)2.60710966
28Progressive inability to walk (HP:0002505)2.57512204
29Nephronophthisis (HP:0000090)2.53110799
30Symptomatic seizures (HP:0011145)2.51160964
31Small hand (HP:0200055)2.50479968
32Bifid scrotum (HP:0000048)2.42983772
33Neuroectodermal neoplasm (HP:0030061)2.40062564
34Neuroepithelial neoplasm (HP:0030063)2.40062564
35Nervous tissue neoplasm (HP:0030060)2.40062564
36Abnormality of the astrocytes (HP:0100707)2.39856143
37Astrocytoma (HP:0009592)2.39856143
38Abnormality of the renal medulla (HP:0100957)2.35372943
39Clubbing of toes (HP:0100760)2.32852100
40Oligodactyly (hands) (HP:0001180)2.32322722
41B lymphocytopenia (HP:0010976)2.30036682
42Tetraparesis (HP:0002273)2.25316429
43Renal cortical cysts (HP:0000803)2.25228433
44Fair hair (HP:0002286)2.24779571
45Ependymoma (HP:0002888)2.24460380
46Malignant neoplasm of the central nervous system (HP:0100836)2.24100422
47Hypoplastic nipples (HP:0002557)2.21270439
48Long clavicles (HP:0000890)2.18098916
49Attenuation of retinal blood vessels (HP:0007843)2.17399021
50Oligodactyly (HP:0012165)2.15453490
51Wide intermamillary distance (HP:0006610)2.14762929
52Myelodysplasia (HP:0002863)2.12455916
53Intestinal atresia (HP:0011100)2.09894407
54Abnormality of B cell number (HP:0010975)2.08931453
55Small intestinal stenosis (HP:0012848)2.04985500
56Duodenal stenosis (HP:0100867)2.04985500
57Abnormality of the preputium (HP:0100587)2.04241743
58Oligohydramnios (HP:0001562)2.04021297
59Rhabdomyosarcoma (HP:0002859)2.02870820
60Hypoplastic labia majora (HP:0000059)2.01619058
61Chronic hepatic failure (HP:0100626)2.01552492
62Facial hemangioma (HP:0000329)2.00122401
63Ectopic kidney (HP:0000086)1.99894072
64Abnormality of the carotid arteries (HP:0005344)1.99413186
65Intellectual disability, moderate (HP:0002342)1.98928832
66Astigmatism (HP:0000483)1.97281756
67Bone marrow hypocellularity (HP:0005528)1.97094600
68Congenital stationary night blindness (HP:0007642)1.96426946
69Atrophy/Degeneration involving motor neurons (HP:0007373)1.95582162
70Abnormality of the lower motor neuron (HP:0002366)1.94955442
71Abnormality of the duodenum (HP:0002246)1.93876820
72J-shaped sella turcica (HP:0002680)1.93554918
73Abolished electroretinogram (ERG) (HP:0000550)1.90153444
74Tubular atrophy (HP:0000092)1.86439203
75Bifid tongue (HP:0010297)1.86358158
76Cystic liver disease (HP:0006706)1.84850557
77Medulloblastoma (HP:0002885)1.84185509
78Abnormal lung lobation (HP:0002101)1.82347946
79Aganglionic megacolon (HP:0002251)1.81182890
80Zonular cataract (HP:0010920)1.81112422
81Sloping forehead (HP:0000340)1.80870728
82Abnormality of the labia minora (HP:0012880)1.80366934
83Multicystic kidney dysplasia (HP:0000003)1.79307799
84Narrow forehead (HP:0000341)1.78607122
85Abnormal hair whorl (HP:0010721)1.78163730
86Meningioma (HP:0002858)1.77099276
87Abnormality of the nasal septum (HP:0000419)1.76956169
88Medial flaring of the eyebrow (HP:0010747)1.76893829
89Carpal bone hypoplasia (HP:0001498)1.75471852
90Benign neoplasm of the central nervous system (HP:0100835)1.74729538
91Hypoglycemic coma (HP:0001325)1.73599503
92Hypoglycemic seizures (HP:0002173)1.72946237
93Abnormality of the 4th metacarpal (HP:0010012)1.72084320
94Dyskinesia (HP:0100660)1.71608937
95Gastrointestinal atresia (HP:0002589)1.71198648
96Abnormality of the labia majora (HP:0012881)1.70932084
97Tubulointerstitial nephritis (HP:0001970)1.69503439
98Delusions (HP:0000746)1.68634268
99Agnosia (HP:0010524)1.68153990
100Severe combined immunodeficiency (HP:0004430)1.66704241

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR4.34580174
2EIF2AK34.21801236
3BRSK23.20359150
4NUAK13.09803895
5WEE12.99547368
6EIF2AK12.85978782
7ZAK2.64629432
8MAP4K22.43664695
9PNCK2.26890172
10PBK2.23837879
11FRK2.22558005
12PLK42.19149432
13CCNB12.17732822
14BUB12.11185538
15EPHA42.08385920
16TNIK1.92407178
17CDC71.91806670
18MAPK131.81194851
19MKNK11.73430636
20RAF11.70034174
21TTK1.68067569
22MAP3K101.64299296
23PLK31.61784073
24BRSK11.56734392
25MKNK21.56003472
26SRPK11.55793994
27AKT31.49853513
28ADRBK21.49771036
29PLK21.46774715
30EIF2AK21.40296845
31KSR11.36818785
32STK391.35287210
33MAP3K21.32371791
34NTRK31.31736734
35STK31.29936030
36BCKDK1.22887954
37MAP3K131.22453685
38TRIM281.19050896
39ATR1.14080575
40KSR21.13798314
41LATS11.05577306
42BMPR21.03502848
43MAPKAPK30.90433288
44PRKCH0.88353165
45TLK10.84318491
46WNK30.83166024
47ATM0.82884529
48PLK10.82648977
49PASK0.82372677
50BRD40.80148340
51WNK40.79934810
52PRKD30.77150573
53TAF10.73391968
54JAK30.73121526
55MST40.72439852
56PRKCE0.72235186
57DYRK30.71469623
58TSSK60.69624780
59NEK10.69214697
60FGFR20.67941059
61BRAF0.67811708
62CHEK20.66076378
63VRK10.63473735
64CDK80.62501437
65BMPR1B0.61293457
66PAK30.60461613
67SGK20.57782298
68TEC0.56966920
69PDK20.55500193
70CAMK1G0.53804187
71CAMK1D0.51155421
72PIK3CA0.48936898
73MAP2K10.48457774
74PIK3CG0.48089705
75SGK30.45590600
76SYK0.44959532
77ERBB20.44868923
78RIPK40.44253234
79STK40.41786905
80AURKB0.40375357
81CDK30.39672901
82OXSR10.38633771
83NEK20.38320238
84MATK0.36864748
85BCR0.34331148
86MAPKAPK50.33135103
87GSK3A0.32065106
88VRK20.31412893
89CHEK10.31007140
90TGFBR10.29797118
91FGFR10.29180738
92GRK10.27143738
93PRKAA10.25674428
94CDK10.24956187
95CSNK2A10.24603602
96IRAK10.23126916
97PRKDC0.22859317
98NEK60.22040438
99ERBB30.22002208
100RIPK10.20943331

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034403.92985014
2Mismatch repair_Homo sapiens_hsa034303.88985687
3DNA replication_Homo sapiens_hsa030303.61574173
4Fanconi anemia pathway_Homo sapiens_hsa034603.51946826
5Proteasome_Homo sapiens_hsa030503.43580991
6Selenocompound metabolism_Homo sapiens_hsa004503.10461933
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.98581264
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.62828947
9Protein export_Homo sapiens_hsa030602.60195178
10RNA polymerase_Homo sapiens_hsa030202.45390461
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.40423890
12Nucleotide excision repair_Homo sapiens_hsa034202.15357817
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.03657826
14Spliceosome_Homo sapiens_hsa030402.02599617
15Base excision repair_Homo sapiens_hsa034102.01386183
16Cell cycle_Homo sapiens_hsa041102.01287997
17RNA transport_Homo sapiens_hsa030131.95692886
18RNA degradation_Homo sapiens_hsa030181.85109807
19Basal transcription factors_Homo sapiens_hsa030221.81402718
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.62626587
21Non-homologous end-joining_Homo sapiens_hsa034501.62547816
22mRNA surveillance pathway_Homo sapiens_hsa030151.48251491
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.40839735
24Propanoate metabolism_Homo sapiens_hsa006401.40414507
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38705240
26One carbon pool by folate_Homo sapiens_hsa006701.37805287
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.36233165
28Pyrimidine metabolism_Homo sapiens_hsa002401.32910257
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.30000460
30Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.29596210
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.26104829
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.21857041
33Dorso-ventral axis formation_Homo sapiens_hsa043201.20177389
34Regulation of autophagy_Homo sapiens_hsa041401.06153533
35Purine metabolism_Homo sapiens_hsa002301.04765714
36Primary immunodeficiency_Homo sapiens_hsa053401.01994814
37Oocyte meiosis_Homo sapiens_hsa041141.01846221
38Olfactory transduction_Homo sapiens_hsa047400.98428480
39Prostate cancer_Homo sapiens_hsa052150.92491846
40Hedgehog signaling pathway_Homo sapiens_hsa043400.92201661
41Primary bile acid biosynthesis_Homo sapiens_hsa001200.90838310
42p53 signaling pathway_Homo sapiens_hsa041150.89261873
43Parkinsons disease_Homo sapiens_hsa050120.86957963
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80551791
45Steroid biosynthesis_Homo sapiens_hsa001000.69577183
46Basal cell carcinoma_Homo sapiens_hsa052170.68668268
47Drug metabolism - other enzymes_Homo sapiens_hsa009830.68112011
48SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67481882
49Chemical carcinogenesis_Homo sapiens_hsa052040.66268345
50Butanoate metabolism_Homo sapiens_hsa006500.65296877
51Glutathione metabolism_Homo sapiens_hsa004800.62636545
52Caffeine metabolism_Homo sapiens_hsa002320.61766072
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.60972657
54Huntingtons disease_Homo sapiens_hsa050160.60947990
55Phototransduction_Homo sapiens_hsa047440.60260413
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60146339
57Oxidative phosphorylation_Homo sapiens_hsa001900.59038365
58Platelet activation_Homo sapiens_hsa046110.57815115
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56275959
60Thyroid cancer_Homo sapiens_hsa052160.55523108
61Thyroid hormone synthesis_Homo sapiens_hsa049180.55497839
62Pyruvate metabolism_Homo sapiens_hsa006200.54380860
63Taste transduction_Homo sapiens_hsa047420.52459130
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52286547
65Melanoma_Homo sapiens_hsa052180.50520203
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50290778
67Melanogenesis_Homo sapiens_hsa049160.48422363
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45814606
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43521141
70PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43318247
71Nitrogen metabolism_Homo sapiens_hsa009100.41273194
72Lysine degradation_Homo sapiens_hsa003100.41192263
73Sulfur metabolism_Homo sapiens_hsa009200.40837199
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38536577
75Long-term depression_Homo sapiens_hsa047300.38391498
76Arachidonic acid metabolism_Homo sapiens_hsa005900.37549060
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.36197821
78Legionellosis_Homo sapiens_hsa051340.31044339
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29480693
80Epstein-Barr virus infection_Homo sapiens_hsa051690.29126642
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27565246
82Measles_Homo sapiens_hsa051620.26827999
83Fatty acid elongation_Homo sapiens_hsa000620.26193717
84N-Glycan biosynthesis_Homo sapiens_hsa005100.25507836
85FoxO signaling pathway_Homo sapiens_hsa040680.24959706
86Ether lipid metabolism_Homo sapiens_hsa005650.24666187
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.23965500
88Metabolic pathways_Homo sapiens_hsa011000.23516276
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23013160
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.22582205
91MicroRNAs in cancer_Homo sapiens_hsa052060.22122030
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21364782
93Estrogen signaling pathway_Homo sapiens_hsa049150.20921018
94TGF-beta signaling pathway_Homo sapiens_hsa043500.20636333
95HTLV-I infection_Homo sapiens_hsa051660.19067936
96Pathways in cancer_Homo sapiens_hsa052000.18288830
97Serotonergic synapse_Homo sapiens_hsa047260.18036720
98Alzheimers disease_Homo sapiens_hsa050100.17766544
99Pancreatic cancer_Homo sapiens_hsa052120.16902513
100Herpes simplex infection_Homo sapiens_hsa051680.16611788

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