FES

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)5.66840074
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.44629226
3positive regulation by organism of defense response of other organism involved in symbiotic interact5.44629226
4modulation by symbiont of host immune response (GO:0052553)5.44629226
5positive regulation by symbiont of host defense response (GO:0052509)5.44629226
6modulation by symbiont of host defense response (GO:0052031)5.44629226
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.44629226
8response to peptidoglycan (GO:0032494)5.14484682
9detection of other organism (GO:0098543)4.96300596
10neutrophil mediated immunity (GO:0002446)4.95832634
11respiratory burst (GO:0045730)4.88051500
12detection of bacterium (GO:0016045)4.85535764
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.72184086
14regulation of interferon-beta biosynthetic process (GO:0045357)4.67864589
15negative regulation of phagocytosis (GO:0050765)4.61089810
16regulation of B cell receptor signaling pathway (GO:0050855)4.56002857
17immunoglobulin mediated immune response (GO:0016064)4.48370365
18positive regulation of B cell differentiation (GO:0045579)4.32452006
19macrophage activation involved in immune response (GO:0002281)4.31636317
20antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.26314188
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.26314188
22regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.26283517
23negative regulation of erythrocyte differentiation (GO:0045647)4.26153958
24response to fungus (GO:0009620)4.22919606
25neutrophil activation (GO:0042119)4.15098463
26cellular extravasation (GO:0045123)4.14307996
27leukocyte aggregation (GO:0070486)4.12407348
28detection of external biotic stimulus (GO:0098581)4.04902009
29regulation of gamma-delta T cell activation (GO:0046643)4.01361350
30positive regulation of gamma-delta T cell activation (GO:0046645)4.00977700
31antigen processing and presentation of endogenous antigen (GO:0019883)3.94867324
32positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.93857640
33granulocyte activation (GO:0036230)3.92128072
34response to host immune response (GO:0052572)3.89859959
35response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.89859959
36myeloid leukocyte mediated immunity (GO:0002444)3.86529005
37response to muramyl dipeptide (GO:0032495)3.84470473
38negative regulation of lymphocyte mediated immunity (GO:0002707)3.83181239
39myeloid cell activation involved in immune response (GO:0002275)3.82969722
40leukocyte migration involved in inflammatory response (GO:0002523)3.76731807
41negative regulation of granulocyte differentiation (GO:0030853)3.76333583
42defense response to fungus (GO:0050832)3.74919044
43production of molecular mediator involved in inflammatory response (GO:0002532)3.70802852
44positive regulation of interferon-alpha production (GO:0032727)3.68250657
45regulation of gamma-delta T cell differentiation (GO:0045586)3.64967201
46detection of biotic stimulus (GO:0009595)3.63791845
47positive regulation of antigen processing and presentation (GO:0002579)3.62988449
48response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.55665366
49response to host (GO:0075136)3.55665366
50response to host defenses (GO:0052200)3.55665366
51positive regulation of mast cell activation (GO:0033005)3.54404410
52negative regulation of leukocyte mediated immunity (GO:0002704)3.54287290
53regulation of B cell differentiation (GO:0045577)3.54218286
54pinocytosis (GO:0006907)3.50492689
55positive thymic T cell selection (GO:0045059)3.48705688
56detection of molecule of bacterial origin (GO:0032490)3.46772783
57regulation of interferon-alpha production (GO:0032647)3.46507557
58response to interleukin-15 (GO:0070672)3.44020924
59negative regulation of T cell mediated immunity (GO:0002710)3.43693416
60Arp2/3 complex-mediated actin nucleation (GO:0034314)3.35683056
61* regulation of mast cell activation (GO:0033003)3.35611950
62defense response to protozoan (GO:0042832)3.33993361
63leukocyte mediated cytotoxicity (GO:0001909)3.32686144
64positive regulation of mast cell degranulation (GO:0043306)3.31144339
65positive regulation of mast cell activation involved in immune response (GO:0033008)3.31144339
66B cell mediated immunity (GO:0019724)3.30461963
67disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.30297426
68killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.30297426
69* regulation of mast cell degranulation (GO:0043304)3.29642618
70negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.24255038
71negative regulation of cell killing (GO:0031342)3.24255038
72negative regulation of interleukin-12 production (GO:0032695)3.22699798
73B cell receptor signaling pathway (GO:0050853)3.22269746
74leukotriene metabolic process (GO:0006691)3.22132113
75cellular response to interleukin-15 (GO:0071350)3.20629871
76positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.19535123
77regulation of dendritic cell antigen processing and presentation (GO:0002604)3.18719887
78reactive oxygen species biosynthetic process (GO:1903409)3.18199227
79negative regulation of innate immune response (GO:0045824)3.18126399
80response to protozoan (GO:0001562)3.17996859
81negative regulation of growth of symbiont in host (GO:0044130)3.17762518
82negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.17762518
83modulation of growth of symbiont involved in interaction with host (GO:0044144)3.17762518
84regulation of growth of symbiont in host (GO:0044126)3.17762518
85negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.16276088
86regulation of antigen processing and presentation (GO:0002577)3.16081930
87positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.15984606
88macrophage differentiation (GO:0030225)3.14245991
89positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.13384973
90* regulation of mast cell activation involved in immune response (GO:0033006)3.12996481
91microglial cell activation (GO:0001774)3.11071796
92leukocyte degranulation (GO:0043299)3.10294369
93positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.09547939
94interferon-gamma-mediated signaling pathway (GO:0060333)3.07817369
95superoxide anion generation (GO:0042554)3.06379040
96regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.03715573
97negative thymic T cell selection (GO:0045060)3.01074035
98lipopolysaccharide-mediated signaling pathway (GO:0031663)2.98964566
99antigen processing and presentation via MHC class Ib (GO:0002475)2.98825343
100neutrophil chemotaxis (GO:0030593)2.96587631
101myeloid dendritic cell activation (GO:0001773)2.96249219
102regulation of interleukin-8 biosynthetic process (GO:0045414)2.95368223
103macrophage activation (GO:0042116)2.95034115
104negative regulation of cytokine production involved in immune response (GO:0002719)2.92505351
105germinal center formation (GO:0002467)2.92154802
106mast cell activation (GO:0045576)2.91501462
107tolerance induction (GO:0002507)2.90495277
108myeloid leukocyte activation (GO:0002274)2.89055334
109neutrophil migration (GO:1990266)2.87587124
110* regulation of myeloid leukocyte mediated immunity (GO:0002886)2.85778141
111* regulation of regulated secretory pathway (GO:1903305)2.85597509
112response to type I interferon (GO:0034340)2.85323637
113cellular response to type I interferon (GO:0071357)2.85284320
114type I interferon signaling pathway (GO:0060337)2.85284320
115mannose metabolic process (GO:0006013)2.83499100
116negative T cell selection (GO:0043383)2.82033048
117response to interferon-beta (GO:0035456)2.81188786
118regulation of tolerance induction (GO:0002643)2.81068408
119* regulation of leukocyte degranulation (GO:0043300)2.79271300
120regulation of T cell mediated cytotoxicity (GO:0001914)2.78275177
121hydrogen peroxide biosynthetic process (GO:0050665)2.77225366
122negative regulation of interleukin-17 production (GO:0032700)2.76584951
123cellular response to zinc ion (GO:0071294)2.76143176
124positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.75812276
125positive regulation of interferon-beta production (GO:0032728)2.75582506
126negative regulation of mast cell activation (GO:0033004)2.75346199
127T cell selection (GO:0045058)2.73671566
128negative regulation of interleukin-6 production (GO:0032715)2.73292993
129T cell migration (GO:0072678)2.71684103
130leukocyte cell-cell adhesion (GO:0007159)2.70351284
131actin nucleation (GO:0045010)2.69772583
132regulation of phagocytosis (GO:0050764)2.67768305
133megakaryocyte development (GO:0035855)2.67209515

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.01628553
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.96675034
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.70899508
4E2F7_22180533_ChIP-Seq_HELA_Human3.94266944
5* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.92392174
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.67309792
7MYB_21317192_ChIP-Seq_ERMYB_Mouse3.65456959
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.53746490
9SCL_19346495_ChIP-Seq_HPC-7_Human3.24291938
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.24069527
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.07528988
12EGR1_19374776_ChIP-ChIP_THP-1_Human3.06200931
13VDR_21846776_ChIP-Seq_THP-1_Human2.90751392
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.87803797
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.80989066
16* SPI1_23547873_ChIP-Seq_NB4_Human2.75300836
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.69180331
18* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.59188891
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.57686688
20BRD4_27068464_Chip-Seq_AML-cells_Mouse2.53962477
21* VDR_24763502_ChIP-Seq_THP-1_Human2.35401302
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.32972320
23Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.30723301
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.24649364
25RUNX1_22412390_ChIP-Seq_EML_Mouse2.23560780
26STAT4_19710469_ChIP-ChIP_TH1__Mouse2.19043005
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.14000258
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.13525803
29ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.10920708
30SPI1_23127762_ChIP-Seq_K562_Human2.05580599
31MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.98551651
32MYC_22102868_ChIP-Seq_BL_Human1.97134649
33MYB_26560356_Chip-Seq_TH2_Human1.96736972
34* MAF_26560356_Chip-Seq_TH1_Human1.91372469
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.83355509
36MYB_26560356_Chip-Seq_TH1_Human1.78462831
37* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.76002294
38LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.71189894
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.70220660
40PU_27001747_Chip-Seq_BMDM_Mouse1.67259507
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.64571629
42FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.64106293
43TCF7_22412390_ChIP-Seq_EML_Mouse1.63385813
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.60994498
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.60380662
46UTX_26944678_Chip-Seq_JUKART_Human1.60334746
47PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.56826158
48* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.56555459
49RUNX_20019798_ChIP-Seq_JUKART_Human1.56419386
50* LXR_22292898_ChIP-Seq_THP-1_Human1.54924893
51FOXM1_23109430_ChIP-Seq_U2OS_Human1.54528721
52LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.51987524
53GATA2_22383799_ChIP-Seq_G1ME_Mouse1.50567639
54CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.50510413
55E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.49964698
56GATA1_22025678_ChIP-Seq_K562_Human1.46367660
57* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.44766188
58CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43597053
59EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.41459578
60BCL6_27268052_Chip-Seq_Bcells_Human1.33368186
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31547173
62GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.31281153
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30657499
64SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.29842110
65* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27317134
66* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.26648298
67* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.26166721
68ELK3_25401928_ChIP-Seq_HUVEC_Human1.24492793
69CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23439357
70BCOR_27268052_Chip-Seq_Bcells_Human1.23198388
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22368701
72GATA1_19941827_ChIP-Seq_MEL_Mouse1.20072482
73GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19035173
74ELF1_20517297_ChIP-Seq_JURKAT_Human1.18808166
75SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12655145
76PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12394609
77VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.12281153
78GATA3_27048872_Chip-Seq_THYMUS_Human1.12217149
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12036572
80VDR_24787735_ChIP-Seq_THP-1_Human1.11272466
81* MAF_26560356_Chip-Seq_TH2_Human1.10965684
82CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10771586
83TFEB_21752829_ChIP-Seq_HELA_Human1.09138250
84PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09070046
85VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07503040
86KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06381832
87E2F4_17652178_ChIP-ChIP_JURKAT_Human1.06121466
88GATA2_21666600_ChIP-Seq_HMVEC_Human1.05787984
89RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02674153
90GATA3_26560356_Chip-Seq_TH2_Human1.02435018
91* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01828541
92IKZF1_21737484_ChIP-ChIP_HCT116_Human1.01613841
93KDM2B_26808549_Chip-Seq_JURKAT_Human1.01562875
94NOTCH1_21737748_ChIP-Seq_TLL_Human1.01417174
95THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00012375
96NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99673848
97NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.95814757
98P68_20966046_ChIP-Seq_HELA_Human0.95314306
99PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91467423
100SA1_27219007_Chip-Seq_ERYTHROID_Human0.90431478
101SPI1_20517297_ChIP-Seq_HL60_Human0.90008923
102PPARA_22158963_ChIP-Seq_LIVER_Mouse0.89250911
103CIITA_25753668_ChIP-Seq_RAJI_Human0.89047437
104TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87848010
105KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87666073
106KDM2B_26808549_Chip-Seq_DND41_Human0.86394289
107KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.83553388
108TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77448787
109GATA2_19941826_ChIP-Seq_K562_Human0.76455220
110GATA1_19941826_ChIP-Seq_K562_Human0.76175101
111* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75045590
112NCOR1_26117541_ChIP-Seq_K562_Human0.74366997
113FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.74207457
114E2F1_21310950_ChIP-Seq_MCF-7_Human0.73551059
115ETS1_22383799_ChIP-Seq_G1ME_Mouse0.73399287

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.03895375
2MP0003436_decreased_susceptibility_to3.65816852
3MP0003303_peritoneal_inflammation3.52766780
4* MP0002419_abnormal_innate_immunity3.16698077
5MP0009785_altered_susceptibility_to3.01703008
6MP0005058_abnormal_lysosome_morphology2.97793632
7* MP0005025_abnormal_response_to2.77239865
8MP0005464_abnormal_platelet_physiology2.74357193
9MP0005000_abnormal_immune_tolerance2.68216980
10MP0003172_abnormal_lysosome_physiology2.66674058
11MP0002148_abnormal_hypersensitivity_rea2.65196120
12* MP0002452_abnormal_antigen_presenting2.54892287
13MP0001800_abnormal_humoral_immune2.51845288
14MP0002396_abnormal_hematopoietic_system2.46367701
15MP0000685_abnormal_immune_system2.44643135
16MP0005387_immune_system_phenotype2.43084122
17MP0001790_abnormal_immune_system2.43084122
18MP0003724_increased_susceptibility_to2.39241644
19MP0002723_abnormal_immune_serum2.38597205
20MP0005671_abnormal_response_to2.37004933
21* MP0001819_abnormal_immune_cell2.33032744
22* MP0002420_abnormal_adaptive_immunity2.33018807
23MP0005174_abnormal_tail_pigmentation2.23814053
24MP0000569_abnormal_digit_pigmentation2.22799024
25MP0009278_abnormal_bone_marrow2.18573287
26MP0006082_CNS_inflammation2.13999262
27MP0005397_hematopoietic_system_phenotyp2.10225381
28MP0001545_abnormal_hematopoietic_system2.10225381
29MP0003183_abnormal_peptide_metabolism2.05498393
30MP0002166_altered_tumor_susceptibility1.99260253
31MP0001853_heart_inflammation1.95825162
32MP0002405_respiratory_system_inflammati1.95375939
33MP0001533_abnormal_skeleton_physiology1.90937465
34MP0003191_abnormal_cellular_cholesterol1.90880773
35* MP0002398_abnormal_bone_marrow1.87227212
36MP0004808_abnormal_hematopoietic_stem1.86700245
37* MP0000716_abnormal_immune_system1.82833082
38MP0003300_gastrointestinal_ulcer1.81210781
39MP0001845_abnormal_inflammatory_respons1.77295789
40MP0000689_abnormal_spleen_morphology1.71808645
41MP0004510_myositis1.70196804
42MP0000343_altered_response_to1.69264067
43MP0009840_abnormal_foam_cell1.61385929
44* MP0002429_abnormal_blood_cell1.58030662
45MP0002006_tumorigenesis1.57577737
46MP0009333_abnormal_splenocyte_physiolog1.55969761
47* MP0002722_abnormal_immune_system1.55463459
48MP0008469_abnormal_protein_level1.55442222
49MP0010155_abnormal_intestine_physiology1.54790131
50MP0001873_stomach_inflammation1.50206279
51MP0002132_abnormal_respiratory_system1.50133746
52MP0000015_abnormal_ear_pigmentation1.47084492
53MP0004947_skin_inflammation1.44753021
54* MP0000465_gastrointestinal_hemorrhage1.43116460
55MP0003075_altered_response_to1.39970796
56MP0000490_abnormal_crypts_of1.33307112
57MP0000858_altered_metastatic_potential1.31201277
58MP0003448_altered_tumor_morphology1.25103663
59MP0005075_abnormal_melanosome_morpholog1.22413564
60MP0005451_abnormal_body_composition1.20360874
61MP0003806_abnormal_nucleotide_metabolis1.19925816
62MP0009764_decreased_sensitivity_to1.18796275
63MP0003763_abnormal_thymus_physiology1.15694653
64MP0002933_joint_inflammation1.13758100
65MP0003828_pulmonary_edema1.12383679
66MP0003566_abnormal_cell_adhesion1.07204367
67MP0005310_abnormal_salivary_gland1.03795494
68* MP0001851_eye_inflammation1.01514074
69MP0002009_preneoplasia0.97746801
70* MP0000703_abnormal_thymus_morphology0.97656622
71MP0001986_abnormal_taste_sensitivity0.97570166
72MP0000371_diluted_coat_color0.96037218
73MP0003656_abnormal_erythrocyte_physiolo0.95608321
74MP0008004_abnormal_stomach_pH0.94951695
75MP0002998_abnormal_bone_remodeling0.93602258
76MP0010352_gastrointestinal_tract_polyps0.92593876
77MP0009763_increased_sensitivity_to0.90229037
78MP0003866_abnormal_defecation0.89794549
79MP0004381_abnormal_hair_follicle0.89255555
80MP0000249_abnormal_blood_vessel0.87881237
81MP0005166_decreased_susceptibility_to0.86332495
82MP0003693_abnormal_embryo_hatching0.86258293
83MP0002095_abnormal_skin_pigmentation0.86108630
84MP0005390_skeleton_phenotype0.85311177
85MP0008057_abnormal_DNA_replication0.84616059
86MP0005167_abnormal_blood-brain_barrier0.83711616
87* MP0010307_abnormal_tumor_latency0.83590504
88MP0009765_abnormal_xenobiotic_induced0.75353449
89MP0002138_abnormal_hepatobiliary_system0.75311200
90MP0002019_abnormal_tumor_incidence0.74889076
91MP0001663_abnormal_digestive_system0.73996244
92MP0002277_abnormal_respiratory_mucosa0.73599403
93MP0005023_abnormal_wound_healing0.72858193
94MP0003690_abnormal_glial_cell0.71620009
95MP0005319_abnormal_enzyme/_coenzyme0.70294522
96MP0008260_abnormal_autophagy0.67857868
97MP0000604_amyloidosis0.67011038
98MP0005164_abnormal_response_to0.65895819
99MP0001958_emphysema0.64708760
100MP0003279_aneurysm0.64221269
101MP0008007_abnormal_cellular_replicative0.63693117
102MP0005076_abnormal_cell_differentiation0.63600963
103MP0003186_abnormal_redox_activity0.61560880
104MP0003795_abnormal_bone_structure0.59906852
105MP0000609_abnormal_liver_physiology0.59089134
106MP0005165_increased_susceptibility_to0.59050819
107MP0004883_abnormal_blood_vessel0.57989997
108MP0008873_increased_physiological_sensi0.57736716
109MP0002928_abnormal_bile_duct0.57179107
110MP0000313_abnormal_cell_death0.55323978
111MP0000767_abnormal_smooth_muscle0.55025909
112MP0004782_abnormal_surfactant_physiolog0.54981938
113MP0000598_abnormal_liver_morphology0.54021847
114MP0008874_decreased_physiological_sensi0.52440062
115MP0005083_abnormal_biliary_tract0.51107612
116MP0006054_spinal_hemorrhage0.51066194
117MP0005584_abnormal_enzyme/coenzyme_acti0.48399727
118MP0005535_abnormal_body_temperature0.47553774
119MP0004130_abnormal_muscle_cell0.46631634

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.28400310
2Recurrent bacterial skin infections (HP:0005406)6.67486985
3Eczematoid dermatitis (HP:0000976)6.35461101
4Recurrent gram-negative bacterial infections (HP:0005420)5.26829834
5Abnormality of macrophages (HP:0004311)4.56950324
6Elevated erythrocyte sedimentation rate (HP:0003565)4.39656164
7Vacuolated lymphocytes (HP:0001922)4.34169034
8Myositis (HP:0100614)4.31004254
9Recurrent skin infections (HP:0001581)4.18274309
10Chronic obstructive pulmonary disease (HP:0006510)4.13695427
11Obstructive lung disease (HP:0006536)4.13695427
12Mediastinal lymphadenopathy (HP:0100721)4.07698354
13Systemic lupus erythematosus (HP:0002725)3.97261422
14Recurrent fungal infections (HP:0002841)3.92198930
15Increased cerebral lipofuscin (HP:0011813)3.76798633
16Gingivitis (HP:0000230)3.73003404
17Gastrointestinal infarctions (HP:0005244)3.65702680
18Spontaneous hematomas (HP:0007420)3.49988729
19Increased neuronal autofluorescent lipopigment (HP:0002074)3.48095721
20Cellulitis (HP:0100658)3.42559133
21IgM deficiency (HP:0002850)3.35417821
22Orchitis (HP:0100796)3.33121322
23Thrombocytosis (HP:0001894)3.28611468
24Encephalitis (HP:0002383)3.28247989
25Chronic otitis media (HP:0000389)3.24259996
26Periodontitis (HP:0000704)3.20547717
27Petechiae (HP:0000967)3.18806951
28Amyloidosis (HP:0011034)3.17595341
29Meningitis (HP:0001287)3.17580548
30Dysostosis multiplex (HP:0000943)3.15343704
31Recurrent viral infections (HP:0004429)3.14366356
32Prolonged bleeding time (HP:0003010)3.09509939
33Hematochezia (HP:0002573)3.07387743
34Keratoconjunctivitis (HP:0001096)3.01250398
35Vasculitis (HP:0002633)2.91456313
36Chronic mucocutaneous candidiasis (HP:0002728)2.90992219
37Recurrent cutaneous fungal infections (HP:0011370)2.90992219
38Autoimmune thrombocytopenia (HP:0001973)2.90160113
39Abnormality of liposaccharide metabolism (HP:0010968)2.85985914
40Abnormality of glycosphingolipid metabolism (HP:0004343)2.85985914
41Abnormality of glycolipid metabolism (HP:0010969)2.85985914
42Epistaxis (HP:0000421)2.85189134
43Retrobulbar optic neuritis (HP:0100654)2.82130662
44Optic neuritis (HP:0100653)2.82130662
45Glomerulonephritis (HP:0000099)2.80963756
46Osteomyelitis (HP:0002754)2.75621197
47Axonal loss (HP:0003447)2.72078847
48Gingival bleeding (HP:0000225)2.69061283
49Abnormality of the prostate (HP:0008775)2.65979851
50Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.65140938
51Hypochromic microcytic anemia (HP:0004840)2.64716836
52Urticaria (HP:0001025)2.64633718
53Hypochromic anemia (HP:0001931)2.62494880
54Abnormal platelet function (HP:0011869)2.61166749
55Impaired platelet aggregation (HP:0003540)2.61166749
56Stomatitis (HP:0010280)2.60070989
57Inflammation of the large intestine (HP:0002037)2.59812148
58Disinhibition (HP:0000734)2.59658214
59Episodic fever (HP:0001954)2.59333025
60Arterial thrombosis (HP:0004420)2.58689884
61Agnosia (HP:0010524)2.58433122
62Pustule (HP:0200039)2.58120942
63Mucopolysacchariduria (HP:0008155)2.56764357
64Urinary glycosaminoglycan excretion (HP:0003541)2.56764357
65T lymphocytopenia (HP:0005403)2.54668488
66Interstitial pulmonary disease (HP:0006530)2.51988335
67J-shaped sella turcica (HP:0002680)2.50478752
68Increased serum ferritin (HP:0003281)2.50189897
69Abnormal delayed hypersensitivity skin test (HP:0002963)2.49410793
70Gastrointestinal inflammation (HP:0004386)2.48786741
71Agammaglobulinemia (HP:0004432)2.48681214
72Thoracic kyphosis (HP:0002942)2.48503818
73Leukocytosis (HP:0001974)2.48371264
74Abnormality of mucopolysaccharide metabolism (HP:0011020)2.47635720
75Abnormality of polysaccharide metabolism (HP:0011012)2.47635720
76Abnormality of glycosaminoglycan metabolism (HP:0004371)2.47635720
77Basal ganglia calcification (HP:0002135)2.47464372
78Abnormality of T cells (HP:0002843)2.47011082
79Chest pain (HP:0100749)2.46825753
80Abnormality of T cell number (HP:0011839)2.45503854
81Hemoptysis (HP:0002105)2.44392015
82Anorexia (HP:0002039)2.43208387
83Abnormality of iron homeostasis (HP:0011031)2.39953037
84Loss of speech (HP:0002371)2.38540131
85Colitis (HP:0002583)2.36192942
86Hepatosplenomegaly (HP:0001433)2.31833770
87Pulmonary infiltrates (HP:0002113)2.26337161
88Abnormality of the pleura (HP:0002103)2.25728391
89Increased IgM level (HP:0003496)2.23348060
90Eosinophilia (HP:0001880)2.20782927
91Abnormality of the nasal mucosa (HP:0000433)2.19581028
92Abnormality of the heme biosynthetic pathway (HP:0010472)2.18154821
93Recurrent pneumonia (HP:0006532)2.17402200
94Gangrene (HP:0100758)2.15252068
95Abnormality of the thoracic spine (HP:0100711)2.14153521
96Vertigo (HP:0002321)2.13696800
97Hypergammaglobulinemia (HP:0010702)2.13333085
98Nasal polyposis (HP:0100582)2.13099992
99Granulocytopenia (HP:0001913)2.11045471
100Microcytic anemia (HP:0001935)2.10588172
101Abnormal platelet volume (HP:0011876)2.09815166
102Glomerulopathy (HP:0100820)2.09776868
103Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.09114666
104Abnormality of T cell physiology (HP:0011840)2.08912487
105Thyroiditis (HP:0100646)2.06913989
106Skin ulcer (HP:0200042)2.06769640
107Albinism (HP:0001022)2.05872136
108Pathologic fracture (HP:0002756)2.01827488
109Thrombophlebitis (HP:0004418)2.01510634
110Skin rash (HP:0000988)2.01212371
111Prostate neoplasm (HP:0100787)2.00576813
112Polyneuropathy (HP:0001271)2.00160615
113Peritonitis (HP:0002586)1.99859865
114Increased IgE level (HP:0003212)1.98585677
115Abnormality of the peritoneum (HP:0002585)1.98220933
116Joint hemorrhage (HP:0005261)1.97913676
117Keratoconjunctivitis sicca (HP:0001097)1.96829964
118Abnormality of transition element cation homeostasis (HP:0011030)1.96135516
119Sepsis (HP:0100806)1.95068457
120Recurrent lower respiratory tract infections (HP:0002783)1.93921330
121Premature loss of primary teeth (HP:0006323)1.93443308
122Polycythemia (HP:0001901)1.93230516
123Deformed sella turcica (HP:0002681)1.92688747
124Pulmonary embolism (HP:0002204)1.91280417
125Menorrhagia (HP:0000132)1.90534900
126Abnormality of the lumbar spine (HP:0100712)1.89293715
127Cheilitis (HP:0100825)1.87293757
128Purpura (HP:0000979)1.84881796
129Nephritis (HP:0000123)1.84670920
130Restrictive lung disease (HP:0002091)1.82801611
131Panhypogammaglobulinemia (HP:0003139)1.81659127

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK43.87721858
2MAP4K13.71508416
3BLK3.22076878
4KIT3.13019060
5RIPK42.82637772
6IRAK32.56938660
7TYK22.54421265
8TAOK32.50077340
9ERN12.46859705
10BTK2.36588364
11TBK12.25364467
12TEC2.22658922
13PRPF4B2.18351557
14CSF1R2.17813720
15MAP2K32.06514542
16TGFBR22.06406030
17MAP3K142.00518121
18ZAP701.87419422
19EPHB11.67644378
20SYK1.66613143
21TXK1.66208215
22PIM21.63599807
23IKBKE1.57395229
24JAK31.54598601
25IKBKB1.53676741
26CSK1.49920972
27CLK11.46952064
28* HCK1.41224189
29TAOK11.38941096
30LYN1.32621359
31STK101.28754687
32EEF2K1.28092609
33FLT31.25656591
34LCK1.24492348
35JAK11.22981436
36PKN21.21704713
37CAMK1D1.18881922
38NME21.18613681
39TRPM71.18221999
40MAP3K11.16892055
41MATK1.15865101
42KDR1.09474971
43TTN1.07934930
44PAK41.05322260
45PIM11.04477092
46TAOK21.03688783
47ITK1.02972152
48SIK20.99566273
49GRK60.95953824
50MAP2K20.94116301
51SIK30.93056543
52BMPR20.90136331
53MARK20.89815284
54MAP3K110.89250077
55TRIB30.87996386
56LRRK20.86290491
57MAPK70.82568223
58PTK60.79936028
59MAP3K70.79773172
60MAPK120.79405983
61MAP3K130.76751967
62PRKD20.76591464
63JAK20.76520239
64FGR0.76492247
65PDK10.76469403
66RPS6KA40.75733944
67CAMK1G0.75241880
68IRAK10.73761947
69NEK90.72810128
70RPS6KA60.72165859
71PDPK10.70963008
72SCYL20.70885253
73* FES0.70194349
74FRK0.68997256
75CAMKK20.68487849
76STK40.68142042
77EIF2AK30.67679540
78TESK20.63771215
79PRKCQ0.63499207
80RPS6KL10.62907805
81RPS6KC10.62907805
82CHUK0.61927297
83MAPK40.61462507
84YES10.59995916
85MAP3K30.59880331
86FYN0.59302641
87CDK190.59112049
88FGFR30.59055671
89CDC42BPA0.58602335
90IRAK20.56714244
91SMG10.56199016
92EIF2AK20.55371487
93HIPK20.54515828
94RIPK10.54095285
95STK160.54020523
96CDK60.53709610
97NEK20.52818607
98TIE10.52734000
99MARK30.51486453
100PIK3CG0.50453823
101PRKCD0.50307618
102MAP2K60.48464574
103MAPKAPK20.48273698
104ABL10.47935855
105KSR20.47703877
106MAP3K60.46242179
107TGFBR10.46090758
108VRK10.45416106
109DYRK1B0.45157821
110TNK20.44284045
111PTK2B0.43841098
112ATR0.43528494
113MAP3K80.42751022
114RPS6KA20.42703324
115WEE10.40123119
116EPHA30.40066598
117EGFR0.39519978
118BCKDK0.38813764
119GRK70.37021842
120CDK40.36195082
121CDK70.35659395
122MAP2K40.35455244
123CDK120.35111851
124MAPKAPK30.34216752
125RET0.33590791
126DAPK20.33398011
127PRKG20.32996320
128MAPK110.32951411
129STK110.31616374
130MAPK30.31110446
131RPS6KA10.30896756
132MAP3K100.29312620
133BMX0.28625916
134MAP3K120.28492120
135MAP3K50.28407028

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.27224987
2Other glycan degradation_Homo sapiens_hsa005112.93774302
3Staphylococcus aureus infection_Homo sapiens_hsa051502.92966146
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.55701909
5Osteoclast differentiation_Homo sapiens_hsa043802.51509010
6B cell receptor signaling pathway_Homo sapiens_hsa046622.21342848
7Pertussis_Homo sapiens_hsa051332.19113249
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.17415915
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.06157156
10Lysosome_Homo sapiens_hsa041422.01454008
11Type I diabetes mellitus_Homo sapiens_hsa049401.97417114
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.94795633
13Legionellosis_Homo sapiens_hsa051341.92798387
14Tuberculosis_Homo sapiens_hsa051521.91670433
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.91585092
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.91067374
17Measles_Homo sapiens_hsa051621.88921956
18Asthma_Homo sapiens_hsa053101.84302984
19Malaria_Homo sapiens_hsa051441.80089451
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.79339522
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.79184898
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.75558823
23Hematopoietic cell lineage_Homo sapiens_hsa046401.74446809
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.70779652
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.64413235
26Antigen processing and presentation_Homo sapiens_hsa046121.60744177
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.59463465
28Caffeine metabolism_Homo sapiens_hsa002321.58311952
29DNA replication_Homo sapiens_hsa030301.53996675
30Toxoplasmosis_Homo sapiens_hsa051451.52795073
31Influenza A_Homo sapiens_hsa051641.51838627
32Herpes simplex infection_Homo sapiens_hsa051681.48940598
33Phagosome_Homo sapiens_hsa041451.45136883
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.43512989
35Shigellosis_Homo sapiens_hsa051311.41528568
36Apoptosis_Homo sapiens_hsa042101.40160943
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.35152458
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.34175658
39Salmonella infection_Homo sapiens_hsa051321.31925011
40Chemokine signaling pathway_Homo sapiens_hsa040621.30896227
41Allograft rejection_Homo sapiens_hsa053301.27957344
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.26153782
43Primary immunodeficiency_Homo sapiens_hsa053401.24198318
44TNF signaling pathway_Homo sapiens_hsa046681.23421260
45Hepatitis B_Homo sapiens_hsa051611.16647424
46Acute myeloid leukemia_Homo sapiens_hsa052211.16457127
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.13449079
48Platelet activation_Homo sapiens_hsa046111.13322704
49Rheumatoid arthritis_Homo sapiens_hsa053231.11577330
50Graft-versus-host disease_Homo sapiens_hsa053321.09501273
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.06130816
52Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97504162
53Base excision repair_Homo sapiens_hsa034100.95681727
54Chronic myeloid leukemia_Homo sapiens_hsa052200.92595583
55Viral myocarditis_Homo sapiens_hsa054160.91616697
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84473457
57Pentose phosphate pathway_Homo sapiens_hsa000300.82164228
58Renin-angiotensin system_Homo sapiens_hsa046140.80713280
59Hepatitis C_Homo sapiens_hsa051600.78863747
60Pancreatic cancer_Homo sapiens_hsa052120.78828050
61Epstein-Barr virus infection_Homo sapiens_hsa051690.78291644
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77288316
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76406345
64African trypanosomiasis_Homo sapiens_hsa051430.73820806
65Ribosome_Homo sapiens_hsa030100.73463778
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71320463
67Complement and coagulation cascades_Homo sapiens_hsa046100.68881392
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.67890820
69T cell receptor signaling pathway_Homo sapiens_hsa046600.67516945
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.67079403
71Homologous recombination_Homo sapiens_hsa034400.66882676
72Mismatch repair_Homo sapiens_hsa034300.63909217
73Small cell lung cancer_Homo sapiens_hsa052220.60708982
74Amoebiasis_Homo sapiens_hsa051460.57643669
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55646733
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.53148030
77Prolactin signaling pathway_Homo sapiens_hsa049170.52904751
78N-Glycan biosynthesis_Homo sapiens_hsa005100.52441142
79Viral carcinogenesis_Homo sapiens_hsa052030.51460476
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.50231421
81p53 signaling pathway_Homo sapiens_hsa041150.49517674
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.48474142
83HIF-1 signaling pathway_Homo sapiens_hsa040660.47321731
84VEGF signaling pathway_Homo sapiens_hsa043700.46605840
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45432455
86Non-small cell lung cancer_Homo sapiens_hsa052230.44805633
87Galactose metabolism_Homo sapiens_hsa000520.43471008
88Regulation of autophagy_Homo sapiens_hsa041400.42311878
89ABC transporters_Homo sapiens_hsa020100.42226712
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41215801
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39568954
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39207471
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39146095
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38594545
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38500929
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37503410
97HTLV-I infection_Homo sapiens_hsa051660.37459268
98Notch signaling pathway_Homo sapiens_hsa043300.36630944
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36066131
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35517045
101Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35341659
102Non-homologous end-joining_Homo sapiens_hsa034500.35192154
103Autoimmune thyroid disease_Homo sapiens_hsa053200.35005125
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34449704
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34006624
106GnRH signaling pathway_Homo sapiens_hsa049120.33803051
107Endocytosis_Homo sapiens_hsa041440.32999554
108Choline metabolism in cancer_Homo sapiens_hsa052310.31441557
109Inositol phosphate metabolism_Homo sapiens_hsa005620.31233972
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30467547
111MAPK signaling pathway_Homo sapiens_hsa040100.30313536
112Fanconi anemia pathway_Homo sapiens_hsa034600.28551189
113Insulin resistance_Homo sapiens_hsa049310.28351386
114mTOR signaling pathway_Homo sapiens_hsa041500.28236415
115FoxO signaling pathway_Homo sapiens_hsa040680.28009814
116Collecting duct acid secretion_Homo sapiens_hsa049660.27692670
117Systemic lupus erythematosus_Homo sapiens_hsa053220.27437118
118Arachidonic acid metabolism_Homo sapiens_hsa005900.27251502
119Renal cell carcinoma_Homo sapiens_hsa052110.25453451
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23540994
121Dorso-ventral axis formation_Homo sapiens_hsa043200.18711680

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »