FETUB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the fetuin family, part of the cystatin superfamily of cysteine protease inhibitors. Fetuins have been implicated in several diverse functions, including osteogenesis and bone resorption, regulation of the insulin and hepatocyte growth factor receptors, and response to systemic inflammation. This protein may be secreted by cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)7.89984330
2L-phenylalanine catabolic process (GO:0006559)7.54621125
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.54621125
4exogenous drug catabolic process (GO:0042738)7.48104992
5L-phenylalanine metabolic process (GO:0006558)7.23022676
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.23022676
7omega-hydroxylase P450 pathway (GO:0097267)7.06256356
8aromatic amino acid family catabolic process (GO:0009074)6.80964246
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.34288673
10drug metabolic process (GO:0017144)6.30734385
11phenylpropanoid metabolic process (GO:0009698)6.23817284
12tryptophan catabolic process (GO:0006569)6.17613254
13indole-containing compound catabolic process (GO:0042436)6.17613254
14indolalkylamine catabolic process (GO:0046218)6.17613254
15kynurenine metabolic process (GO:0070189)6.03905321
16oxidative demethylation (GO:0070989)6.02845354
17bile acid biosynthetic process (GO:0006699)5.96133590
18negative regulation of fibrinolysis (GO:0051918)5.81521769
19glyoxylate metabolic process (GO:0046487)5.81136814
20tryptophan metabolic process (GO:0006568)5.79714051
21high-density lipoprotein particle remodeling (GO:0034375)5.68789819
22urea metabolic process (GO:0019627)5.64969171
23urea cycle (GO:0000050)5.64969171
24regulation of fibrinolysis (GO:0051917)5.58900901
25regulation of protein activation cascade (GO:2000257)5.56316723
26complement activation, alternative pathway (GO:0006957)5.56247446
27protein carboxylation (GO:0018214)5.50745460
28peptidyl-glutamic acid carboxylation (GO:0017187)5.50745460
29sulfur amino acid catabolic process (GO:0000098)5.48971038
30alpha-linolenic acid metabolic process (GO:0036109)5.38684057
31cysteine metabolic process (GO:0006534)5.38143120
32nitrogen cycle metabolic process (GO:0071941)5.19480361
33regulation of complement activation (GO:0030449)5.18854841
34serine family amino acid catabolic process (GO:0009071)5.15124677
35bile acid metabolic process (GO:0008206)5.09444322
36regulation of plasminogen activation (GO:0010755)5.06397997
37ethanol metabolic process (GO:0006067)5.04385280
38negative regulation of blood coagulation (GO:0030195)4.99827201
39negative regulation of hemostasis (GO:1900047)4.99827201
40reverse cholesterol transport (GO:0043691)4.95914105
41aromatic amino acid family metabolic process (GO:0009072)4.94366424
42regulation of cholesterol esterification (GO:0010872)4.93418330
43alkaloid metabolic process (GO:0009820)4.85510883
44regulation of triglyceride catabolic process (GO:0010896)4.83361972
45protein-lipid complex remodeling (GO:0034368)4.82352613
46macromolecular complex remodeling (GO:0034367)4.82352613
47plasma lipoprotein particle remodeling (GO:0034369)4.82352613
48tyrosine metabolic process (GO:0006570)4.77566636
49fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.77120925
50homocysteine metabolic process (GO:0050667)4.66459419
51triglyceride homeostasis (GO:0070328)4.64585480
52acylglycerol homeostasis (GO:0055090)4.64585480
53alpha-amino acid catabolic process (GO:1901606)4.61498714
54negative regulation of wound healing (GO:0061045)4.60859604
55phospholipid efflux (GO:0033700)4.59297324
56hormone catabolic process (GO:0042447)4.59268406
57amino-acid betaine metabolic process (GO:0006577)4.56673332
58negative regulation of cholesterol transport (GO:0032375)4.54549992
59negative regulation of sterol transport (GO:0032372)4.54549992
60negative regulation of coagulation (GO:0050819)4.54484530
61lysine metabolic process (GO:0006553)4.53767998
62lysine catabolic process (GO:0006554)4.53767998
63steroid catabolic process (GO:0006706)4.45170815
64glycine metabolic process (GO:0006544)4.41707200
65plasma lipoprotein particle clearance (GO:0034381)4.37948835
66cellular glucuronidation (GO:0052695)4.37354406
67cellular ketone body metabolic process (GO:0046950)4.36285090
68imidazole-containing compound metabolic process (GO:0052803)4.36249372
69coenzyme catabolic process (GO:0009109)4.36078838
70bile acid and bile salt transport (GO:0015721)4.35919100
71indolalkylamine metabolic process (GO:0006586)4.35734568
72negative regulation of complement activation (GO:0045916)4.34970540
73regulation of humoral immune response (GO:0002920)4.29004800
74ethanol oxidation (GO:0006069)4.28722846
75cellular biogenic amine catabolic process (GO:0042402)4.27848634
76amine catabolic process (GO:0009310)4.27848634
77cellular amino acid catabolic process (GO:0009063)4.25427457
78cholesterol efflux (GO:0033344)4.25275216
79glutamate metabolic process (GO:0006536)4.19566544
80serine family amino acid metabolic process (GO:0009069)4.17004152
81fibrinolysis (GO:0042730)4.16780588
82benzene-containing compound metabolic process (GO:0042537)4.15901047
83positive regulation of hemostasis (GO:1900048)4.10127344
84positive regulation of blood coagulation (GO:0030194)4.10127344
85aldehyde catabolic process (GO:0046185)4.06356745
86arginine metabolic process (GO:0006525)4.04595515
87cellular modified amino acid catabolic process (GO:0042219)4.04276819
88S-adenosylmethionine metabolic process (GO:0046500)4.00542815
89serine family amino acid biosynthetic process (GO:0009070)3.97474054
90plasma lipoprotein particle assembly (GO:0034377)3.97159592
91low-density lipoprotein particle remodeling (GO:0034374)3.96736659
92blood coagulation, intrinsic pathway (GO:0007597)3.95409078
93dicarboxylic acid biosynthetic process (GO:0043650)3.94151557
94complement activation, classical pathway (GO:0006958)3.93856908
95uronic acid metabolic process (GO:0006063)3.91666972
96glucuronate metabolic process (GO:0019585)3.91666972
97drug catabolic process (GO:0042737)3.90608667
98complement activation (GO:0006956)3.87674119
99protein activation cascade (GO:0072376)3.86025576
100positive regulation of triglyceride lipase activity (GO:0061365)3.84612399
101positive regulation of lipoprotein lipase activity (GO:0051006)3.84612399
102flavonoid metabolic process (GO:0009812)3.82952568
103negative regulation of lipase activity (GO:0060192)3.81438346
104positive regulation of coagulation (GO:0050820)3.79860941
105cofactor catabolic process (GO:0051187)3.79751513
106cytolysis (GO:0019835)3.77796583
107ketone body metabolic process (GO:1902224)3.77238721
108regulation of bile acid biosynthetic process (GO:0070857)3.75128266
109acute-phase response (GO:0006953)3.73289167
110cholesterol homeostasis (GO:0042632)3.72684490
111organic acid catabolic process (GO:0016054)3.71156025
112carboxylic acid catabolic process (GO:0046395)3.71156025
113positive regulation of lipid catabolic process (GO:0050996)3.69621556
114phospholipid homeostasis (GO:0055091)3.68960077
115very-low-density lipoprotein particle assembly (GO:0034379)3.68163615
116xenobiotic metabolic process (GO:0006805)3.67141645
117sterol homeostasis (GO:0055092)3.66505781
118regulation of cholesterol homeostasis (GO:2000188)3.65034328
119negative regulation of protein activation cascade (GO:2000258)3.64618758
120plasma lipoprotein particle organization (GO:0071827)3.64572981
121regulation of lipoprotein particle clearance (GO:0010984)3.63406188
122heme transport (GO:0015886)3.62386502
123short-chain fatty acid metabolic process (GO:0046459)3.61693375
124opsonization (GO:0008228)3.60291007
125acute inflammatory response (GO:0002526)3.51444386
126cholesterol catabolic process (GO:0006707)3.45762336
127sterol catabolic process (GO:0016127)3.45762336
128drug transmembrane transport (GO:0006855)3.45153390
129negative regulation of humoral immune response (GO:0002921)3.44148880
130proline metabolic process (GO:0006560)3.42804903
131fat-soluble vitamin biosynthetic process (GO:0042362)3.41437228

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.36785615
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.16111305
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.97578352
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.44943067
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.29009275
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.20310216
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.86062421
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.10095642
9* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.98287238
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.05075066
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9853061
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93883697
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.93205644
14* FOXA2_19822575_ChIP-Seq_HepG2_Human1.58734807
15CLOCK_20551151_ChIP-Seq_293T_Human1.52259221
16HTT_18923047_ChIP-ChIP_STHdh_Human1.51581447
17TRIM28_21343339_ChIP-Seq_HEK293_Human1.39725507
18* HNF4A_19822575_ChIP-Seq_HepG2_Human1.37979598
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35011536
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.28061377
21GATA1_22025678_ChIP-Seq_K562_Human1.27464131
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.21027564
23NFE2_27457419_Chip-Seq_LIVER_Mouse1.20635646
24* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.20313194
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17900387
26ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16698414
27ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07665074
28CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.05663832
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02399214
30GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.98531779
31SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98488505
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98404831
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.97694441
34HNFA_21074721_ChIP-Seq_CACO-2_Human0.96921094
35EZH2_27294783_Chip-Seq_NPCs_Mouse0.95242181
36ZNF263_19887448_ChIP-Seq_K562_Human0.90969528
37GATA6_21074721_ChIP-Seq_CACO-2_Human0.90949700
38RARG_19884340_ChIP-ChIP_MEFs_Mouse0.90806358
39SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90145223
40PHF8_20622853_ChIP-Seq_HELA_Human0.88173249
41ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85942099
42SOX2_21211035_ChIP-Seq_LN229_Human0.85706182
43AUTS2_25519132_ChIP-Seq_293T-REX_Human0.85271915
44PCGF2_27294783_Chip-Seq_NPCs_Mouse0.84005629
45SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.83286066
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.82807273
47IRF8_22096565_ChIP-ChIP_GC-B_Human0.81075878
48ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.80802753
49GATA4_25053715_ChIP-Seq_YYC3_Human0.80700085
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.80003343
51KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77856696
52CRX_20693478_ChIP-Seq_RETINA_Mouse0.77747595
53SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.77525133
54SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76919368
55RUNX1_27457419_Chip-Seq_LIVER_Mouse0.76448983
56RARA_24833708_ChIP-Seq_LIVER_Mouse0.75809060
57ESR2_21235772_ChIP-Seq_MCF-7_Human0.74384291
58NFYA_21822215_ChIP-Seq_K562_Human0.74164818
59EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.74162390
60IRF1_19129219_ChIP-ChIP_H3396_Human0.73876376
61CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.72048195
62OCT4_21477851_ChIP-Seq_ESCs_Mouse0.71859958
63CBX2_22325352_ChIP-Seq_293T-Rex_Human0.71286744
64PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.70488707
65BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.69892665
66SMAD1_18555785_Chip-Seq_ESCs_Mouse0.69415959
67RAC3_21632823_ChIP-Seq_H3396_Human0.69079039
68ESRRB_18555785_Chip-Seq_ESCs_Mouse0.67879510
69BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.67316142
70RARB_24833708_ChIP-Seq_LIVER_Mouse0.67261349
71AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.66758142
72Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.65929043
73NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.65759506
74OCT4_18555785_Chip-Seq_ESCs_Mouse0.65469392
75EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.65314753
76BP1_19119308_ChIP-ChIP_Hs578T_Human0.65033015
77RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.65007827
78SALL4_18804426_ChIP-ChIP_XEN_Mouse0.64951733
79RAD21_21589869_ChIP-Seq_MESCs_Mouse0.64618610
80PU1_27457419_Chip-Seq_LIVER_Mouse0.63851535
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.63467794
82GATA3_21867929_ChIP-Seq_CD8_Mouse0.63296182
83TP53_18474530_ChIP-ChIP_U2OS_Human0.63161000
84ETV1_20927104_ChIP-Seq_GIST48_Human0.62035758
85SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.61017997
86RBPJ_21746931_ChIP-Seq_IB4_Human0.60470123
87NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.60342928
88NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.60171372
89CTCF_20526341_ChIP-Seq_ESCs_Human0.60006966
90NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.59985059
91TCF4_18268006_ChIP-ChIP_LS174T_Human0.59731582
92CEBPB_22108803_ChIP-Seq_LS180_Human0.59719113
93STAT3_1855785_ChIP-Seq_MESCs_Mouse0.58303616
94KLF4_18555785_Chip-Seq_ESCs_Mouse0.58110021
95* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.58025712
96* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.58025712
97ER_23166858_ChIP-Seq_MCF-7_Human0.57963305
98LXR_22292898_ChIP-Seq_THP-1_Human0.57810154
99ZFX_18555785_Chip-Seq_ESCs_Mouse0.57723984
100CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.57203959
101ETV2_25802403_ChIP-Seq_MESCs_Mouse0.56826481
102SOX2_20726797_ChIP-Seq_SW620_Human0.56552275
103JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.56522024
104PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.56279823
105ESR1_21235772_ChIP-Seq_MCF-7_Human0.55409569
106PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.54685375
107SPI1_20517297_ChIP-Seq_HL60_Human0.54520823
108FOXA1_25552417_ChIP-Seq_VCAP_Human0.54405288
109FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.53783887
110FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.53027628
111MYC_19915707_ChIP-ChIP_AK7_Human0.51038163
112AR_20517297_ChIP-Seq_VCAP_Human0.50257359
113CDX2_20551321_ChIP-Seq_CACO-2_Human0.49567788
114EGR1_19032775_ChIP-ChIP_M12_Human0.48706047
115ESET_19884257_ChIP-Seq_ESCs_Mouse0.48601657
116P53_21459846_ChIP-Seq_SAOS-2_Human0.46808198
117STAT1_17558387_ChIP-Seq_HELA_Human0.46258668
118CBP_21632823_ChIP-Seq_H3396_Human0.45469534
119ESR1_20079471_ChIP-ChIP_T-47D_Human0.45186810
120ERG_21242973_ChIP-ChIP_JURKAT_Human0.44706071
121E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.43965279
122TAF2_19829295_ChIP-Seq_ESCs_Human0.43272400
123PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.42685032
124GATA6_25053715_ChIP-Seq_YYC3_Human0.41960846
125FOXO3_23340844_ChIP-Seq_DLD1_Human0.41542095
126PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.41346652
127* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.41338062
128FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.41309558
129MYC_27129775_Chip-Seq_CORNEA_Mouse0.40989412
130PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.40786621
131STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.40633948
132GATA1_19941826_ChIP-Seq_K562_Human0.39863402
133GATA1_19941827_ChIP-Seq_MEL_Mouse0.39746782
134SPI1_26923725_Chip-Seq_HPCs_Mouse0.38638357
135TAF15_26573619_Chip-Seq_HEK293_Human0.37980076
136ERG_20517297_ChIP-Seq_VCAP_Human0.36976797
137GATA2_19941826_ChIP-Seq_K562_Human0.36975083
138BCAT_22108803_ChIP-Seq_LS180_Human0.36902339
139PPAR_26484153_Chip-Seq_NCI-H1993_Human0.36392272
140OCT4_20526341_ChIP-Seq_ESCs_Human0.35567710
141GATA3_24758297_ChIP-Seq_MCF-7_Human0.35514251
142FOXH1_21741376_ChIP-Seq_EPCs_Human0.35254595
143LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.34835884
144CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.34578490
145BCOR_27268052_Chip-Seq_Bcells_Human0.34564563
146CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.34529270
147SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.34253593

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.24547709
2MP0005360_urolithiasis7.52016852
3MP0005085_abnormal_gallbladder_physiolo6.45131776
4MP0005365_abnormal_bile_salt6.16550634
5MP0008875_abnormal_xenobiotic_pharmacok5.28224988
6MP0003806_abnormal_nucleotide_metabolis4.41261611
7MP0003252_abnormal_bile_duct3.86403704
8MP0010329_abnormal_lipoprotein_level3.58614155
9MP0009840_abnormal_foam_cell3.33384937
10MP0005083_abnormal_biliary_tract3.08620295
11MP0003195_calcinosis2.83255972
12MP0005332_abnormal_amino_acid2.71885640
13MP0001666_abnormal_nutrient_absorption2.58071031
14MP0003191_abnormal_cellular_cholesterol2.45984384
15MP0000609_abnormal_liver_physiology2.15631571
16MP0004019_abnormal_vitamin_homeostasis2.12504813
17MP0002118_abnormal_lipid_homeostasis2.06961826
18MP0002138_abnormal_hepatobiliary_system1.88457224
19MP0003868_abnormal_feces_composition1.86735831
20MP0005319_abnormal_enzyme/_coenzyme1.83861718
21MP0001764_abnormal_homeostasis1.65272668
22MP0005584_abnormal_enzyme/coenzyme_acti1.56487003
23MP0009697_abnormal_copulation1.56384823
24MP0003011_delayed_dark_adaptation1.39138941
25MP0005451_abnormal_body_composition1.38537300
26MP0003186_abnormal_redox_activity1.32327607
27MP0003656_abnormal_erythrocyte_physiolo1.26934870
28MP0009643_abnormal_urine_homeostasis1.21791191
29MP0003705_abnormal_hypodermis_morpholog1.19750466
30MP0000598_abnormal_liver_morphology1.17891453
31MP0005647_abnormal_sex_gland1.16352808
32MP0005187_abnormal_penis_morphology1.13487404
33MP0000604_amyloidosis1.09662435
34MP0009764_decreased_sensitivity_to1.06396874
35MP0002254_reproductive_system_inflammat1.04867104
36MP0009763_increased_sensitivity_to1.03427174
37MP0010368_abnormal_lymphatic_system1.01124578
38MP0001915_intracranial_hemorrhage0.97669551
39MP0005636_abnormal_mineral_homeostasis0.90000621
40MP0008469_abnormal_protein_level0.87744040
41MP0005408_hypopigmentation0.86512711
42MP0009642_abnormal_blood_homeostasis0.85868433
43MP0005376_homeostasis/metabolism_phenot0.81105295
44MP0006036_abnormal_mitochondrial_physio0.80327221
45MP0009765_abnormal_xenobiotic_induced0.78863381
46MP0002090_abnormal_vision0.77788205
47MP0005670_abnormal_white_adipose0.77336498
48MP0002078_abnormal_glucose_homeostasis0.74673981
49MP0005220_abnormal_exocrine_pancreas0.74313144
50MP0005084_abnormal_gallbladder_morpholo0.73246411
51MP0010386_abnormal_urinary_bladder0.72805010
52MP0002876_abnormal_thyroid_physiology0.71690886
53MP0002971_abnormal_brown_adipose0.70964413
54MP0009053_abnormal_anal_canal0.70499494
55MP0005266_abnormal_metabolism0.67614083
56MP0005058_abnormal_lysosome_morphology0.66094230
57MP0001661_extended_life_span0.65895107
58MP0005334_abnormal_fat_pad0.64938868
59MP0003879_abnormal_hair_cell0.64895249
60MP0003690_abnormal_glial_cell0.64187801
61MP0004130_abnormal_muscle_cell0.63283017
62MP0005535_abnormal_body_temperature0.62537060
63MP0000639_abnormal_adrenal_gland0.61737714
64MP0003329_amyloid_beta_deposits0.60822737
65MP0001756_abnormal_urination0.55608851
66MP0002282_abnormal_trachea_morphology0.54156859
67MP0006035_abnormal_mitochondrial_morpho0.54044888
68MP0005395_other_phenotype0.53848328
69MP0005448_abnormal_energy_balance0.53185985
70MP0003718_maternal_effect0.53053379
71MP0005464_abnormal_platelet_physiology0.52944028
72MP0002822_catalepsy0.48852304
73MP0004782_abnormal_surfactant_physiolog0.47181690
74MP0005248_abnormal_Harderian_gland0.46524168
75MP0002928_abnormal_bile_duct0.45825365
76MP0008874_decreased_physiological_sensi0.45483473
77MP0002089_abnormal_postnatal_growth/wei0.45081741
78MP0008873_increased_physiological_sensi0.44443683
79MP0003638_abnormal_response/metabolism_0.43820293
80MP0002136_abnormal_kidney_physiology0.43132934
81MP0001984_abnormal_olfaction0.43082044
82MP0003075_altered_response_to0.42816067
83MP0002249_abnormal_larynx_morphology0.41473355
84MP0003436_decreased_susceptibility_to0.41228971
85MP0000579_abnormal_nail_morphology0.40597150
86MP0005166_decreased_susceptibility_to0.39181431
87MP0003953_abnormal_hormone_level0.38905438
88MP0008872_abnormal_physiological_respon0.38816410
89MP0002796_impaired_skin_barrier0.38422285
90MP0004381_abnormal_hair_follicle0.37766563
91MP0003724_increased_susceptibility_to0.36342129
92MP0009785_altered_susceptibility_to0.36121170
93MP0005666_abnormal_adipose_tissue0.35539356
94MP0002837_dystrophic_cardiac_calcinosis0.34762147
95MP0006082_CNS_inflammation0.33547835
96MP0009115_abnormal_fat_cell0.32974551
97MP0004883_abnormal_blood_vessel0.32758147
98MP0009672_abnormal_birth_weight0.32631807
99MP0000249_abnormal_blood_vessel0.32487779
100MP0002132_abnormal_respiratory_system0.32115647
101MP0002168_other_aberrant_phenotype0.31518154
102MP0002970_abnormal_white_adipose0.29715404
103MP0001243_abnormal_dermal_layer0.29375036
104MP0005197_abnormal_uvea_morphology0.28598288
105MP0005167_abnormal_blood-brain_barrier0.28436700
106MP0009384_cardiac_valve_regurgitation0.26908721
107MP0004264_abnormal_extraembryonic_tissu0.25853589
108MP0005164_abnormal_response_to0.25808852
109MP0003941_abnormal_skin_development0.25771044
110MP0001845_abnormal_inflammatory_respons0.25743166
111MP0001881_abnormal_mammary_gland0.25601133
112MP0000230_abnormal_systemic_arterial0.25462945
113MP0002060_abnormal_skin_morphology0.25429021
114MP0005023_abnormal_wound_healing0.23819276
115MP0001986_abnormal_taste_sensitivity0.22633231
116MP0000467_abnormal_esophagus_morphology0.20665809
117MP0003959_abnormal_lean_body0.19955796
118MP0000920_abnormal_myelination0.17099665
119MP0000566_synostosis0.16855171
120MP0002697_abnormal_eye_size0.15800734
121MP0001440_abnormal_grooming_behavior0.14839657

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.59302035
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.42815622
3Intrahepatic cholestasis (HP:0001406)7.34138800
4Prolonged partial thromboplastin time (HP:0003645)6.71052857
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.70679402
6Hypobetalipoproteinemia (HP:0003563)6.39968488
7Xanthomatosis (HP:0000991)6.22887690
8Complement deficiency (HP:0004431)5.71623138
9Hyperlipoproteinemia (HP:0010980)5.64443555
10Joint hemorrhage (HP:0005261)4.94403900
11Hypolipoproteinemia (HP:0010981)4.85819686
12Abnormality of the common coagulation pathway (HP:0010990)4.65254631
13Hyperammonemia (HP:0001987)4.59716562
14Hyperglycinemia (HP:0002154)4.48561690
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.42200399
16Epidermoid cyst (HP:0200040)4.36119862
17Hypoalphalipoproteinemia (HP:0003233)4.31188450
18Abnormality of methionine metabolism (HP:0010901)4.28773674
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.26834255
20Ketosis (HP:0001946)4.21453990
21Abnormality of complement system (HP:0005339)4.18696849
22Fat malabsorption (HP:0002630)4.13597781
23Abnormality of aspartate family amino acid metabolism (HP:0010899)4.10998575
24Abnormality of glutamine family amino acid metabolism (HP:0010902)4.04723024
25Reduced antithrombin III activity (HP:0001976)4.03421855
26Hyperglycinuria (HP:0003108)3.91053284
27Abnormality of serine family amino acid metabolism (HP:0010894)3.89418960
28Abnormality of glycine metabolism (HP:0010895)3.89418960
29Abnormality of the intrinsic pathway (HP:0010989)3.85904226
30Abnormality of pyrimidine metabolism (HP:0004353)3.83378471
31Hypoglycemic coma (HP:0001325)3.73436068
32Conjugated hyperbilirubinemia (HP:0002908)3.67702841
33Hypercholesterolemia (HP:0003124)3.57668409
34Osteomalacia (HP:0002749)3.34261947
35Spontaneous abortion (HP:0005268)3.33592542
36Abnormality of fatty-acid metabolism (HP:0004359)3.31809861
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.29411411
38Hyperbilirubinemia (HP:0002904)3.28394607
39Hypochromic microcytic anemia (HP:0004840)3.18811095
40Steatorrhea (HP:0002570)3.17175426
41Delayed CNS myelination (HP:0002188)3.12308820
42Abnormality of serum amino acid levels (HP:0003112)3.06874250
43Abnormality of nucleobase metabolism (HP:0010932)3.04579658
44Hepatocellular carcinoma (HP:0001402)3.03943450
45Myocardial infarction (HP:0001658)2.96472044
46Ketoacidosis (HP:0001993)2.93179706
47Systemic lupus erythematosus (HP:0002725)2.84158268
48Metabolic acidosis (HP:0001942)2.75192247
49Skin nodule (HP:0200036)2.66699989
50Abnormality of purine metabolism (HP:0004352)2.65180252
51Glomerulonephritis (HP:0000099)2.61845622
52Lethargy (HP:0001254)2.61024602
53Vascular calcification (HP:0004934)2.60174716
54Arthropathy (HP:0003040)2.55346074
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.54255396
56Dicarboxylic aciduria (HP:0003215)2.54255396
57Recurrent gram-negative bacterial infections (HP:0005420)2.52637038
58Spastic diplegia (HP:0001264)2.50828078
59Purpura (HP:0000979)2.49884190
60Amyloidosis (HP:0011034)2.49854365
61Abnormality of the Achilles tendon (HP:0005109)2.48721416
62Gout (HP:0001997)2.47726960
63Abnormal gallbladder morphology (HP:0012437)2.42948399
64Neonatal onset (HP:0003623)2.40729993
65Acanthocytosis (HP:0001927)2.38904524
66Cerebral edema (HP:0002181)2.38506090
67Hyperphosphaturia (HP:0003109)2.38077600
68Cholelithiasis (HP:0001081)2.37920176
69Mitral stenosis (HP:0001718)2.36212043
70Gingival bleeding (HP:0000225)2.35732924
71Fair hair (HP:0002286)2.35386384
72Hypoglycemic seizures (HP:0002173)2.34975325
73Irritability (HP:0000737)2.33900114
74Cholecystitis (HP:0001082)2.32822697
75Abnormal gallbladder physiology (HP:0012438)2.32822697
76Cardiovascular calcification (HP:0011915)2.30225774
77Esophageal varix (HP:0002040)2.26977312
78Malnutrition (HP:0004395)2.26860387
79Menorrhagia (HP:0000132)2.19930063
80Thrombophlebitis (HP:0004418)2.19443277
81Glycosuria (HP:0003076)2.19427096
82Abnormality of urine glucose concentration (HP:0011016)2.19427096
83Neonatal hypoglycemia (HP:0001998)2.18739514
84Elevated alkaline phosphatase (HP:0003155)2.14114173
85Pancreatitis (HP:0001733)2.14100320
86Sensorimotor neuropathy (HP:0007141)2.11835654
87Enlarged kidneys (HP:0000105)2.11656979
88Late onset (HP:0003584)2.09104905
89Vomiting (HP:0002013)2.07057713
90Opisthotonus (HP:0002179)2.05004676
91Brushfield spots (HP:0001088)2.04800768
92Poikilocytosis (HP:0004447)2.02863135
93Hemorrhage of the eye (HP:0011885)2.02632471
94Bile duct proliferation (HP:0001408)2.00436746
95Abnormal biliary tract physiology (HP:0012439)2.00436746
96Abnormality of the gallbladder (HP:0005264)1.98200821
97Increased serum ferritin (HP:0003281)1.96275081
98Generalized aminoaciduria (HP:0002909)1.95582556
99Abnormality of alkaline phosphatase activity (HP:0004379)1.95385041
100Gangrene (HP:0100758)1.94229376
101Rickets (HP:0002748)1.93737170
102Abnormality of iron homeostasis (HP:0011031)1.91289649
103Atrioventricular block (HP:0001678)1.91205928
104Abnormal urine phosphate concentration (HP:0012599)1.90544959
105Abnormality of transition element cation homeostasis (HP:0011030)1.89425020
106Hyperinsulinemic hypoglycemia (HP:0000825)1.87543021
107Hypophosphatemic rickets (HP:0004912)1.87157936
108Abnormal cartilage morphology (HP:0002763)1.85330511
109Nephritis (HP:0000123)1.84386723
110Renal cortical cysts (HP:0000803)1.81616922
111Elevated hepatic transaminases (HP:0002910)1.80094330
112Status epilepticus (HP:0002133)1.79657546
113Abnormal enzyme/coenzyme activity (HP:0012379)1.78755447
114Alkalosis (HP:0001948)1.78406213
115Abnormality of proline metabolism (HP:0010907)1.75777956
116Hydroxyprolinuria (HP:0003080)1.75777956
117Lower limb hyperreflexia (HP:0002395)1.74093892
118Abnormality of vitamin metabolism (HP:0100508)1.72235408
119Pulmonary embolism (HP:0002204)1.71974776
120Abnormal pupillary function (HP:0007686)1.69340201
121Retinal atrophy (HP:0001105)1.69239822
122Hypophosphatemia (HP:0002148)1.62987999
123Decreased subcutaneous fat (HP:0001002)1.62337355
124Generalized hypopigmentation of hair (HP:0011358)1.61026993
125Achilles tendon contracture (HP:0001771)1.58608528
126Bifid scrotum (HP:0000048)1.57840155

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.25510682
2ERN14.78492499
3FGFR44.69279461
4SIK14.33370152
5TAOK33.01121618
6ERBB42.95672296
7INSRR2.71446454
8PIK3CA2.64922038
9MAP2K42.32431875
10PKN22.10262994
11TRIB32.04430947
12MST1R2.04278885
13MAPK111.91570436
14LATS11.77326922
15PIK3CG1.72012738
16FLT31.71308569
17PDK21.65543282
18TYK21.59045997
19PRPF4B1.57176198
20DAPK21.55505025
21PTK61.45076917
22PRKG11.44143681
23TESK21.44010287
24MAP3K121.42707907
25ABL21.40568816
26WNK31.39310827
27NTRK31.36818156
28STK161.35250586
29NEK91.33964232
30FRK1.25262758
31FGFR21.22837191
32MYLK1.20890545
33MAPK151.20712637
34PINK11.19563586
35KDR1.18173658
36MAP3K71.17022394
37CSNK1D1.16995328
38GRK61.16961022
39PRKACA1.15775320
40TNK21.15034515
41JAK21.14418497
42STK38L1.13575902
43MAP2K31.09228419
44PRKAA21.08157907
45ERBB21.04860581
46SGK11.00202095
47PRKCB0.98412983
48TBK10.96174425
49CDK60.93794944
50MAP3K100.92408260
51MAPK40.92018740
52PRKCZ0.91464302
53MAP3K30.91072322
54JAK10.89319717
55EPHB10.85783036
56MUSK0.84957705
57MAP3K110.84699847
58CAMK2G0.83279883
59EPHA30.82781568
60BLK0.82705307
61MAP3K140.81987777
62MAPK120.81546360
63DYRK1B0.80425033
64MET0.77616079
65EIF2AK30.76766400
66SCYL20.75863432
67TIE10.75737379
68ARAF0.74792749
69RPS6KA30.74275335
70PIM20.74182165
71PRKACG0.72980975
72ZAP700.72201227
73CSK0.71227946
74MAP2K60.70216368
75RIPK10.69778668
76SGK30.66923073
77GSK3A0.65695303
78ICK0.65333867
79MAP3K20.65290801
80CSNK2A20.64321087
81PRKAA10.64063066
82TGFBR20.62739279
83MAPK70.62609073
84PRKACB0.62543030
85CAMK1D0.61212963
86CAMKK10.59818570
87SRC0.58177453
88CSNK1A10.57941097
89FGFR30.56755293
90PTK20.56220065
91CSNK2A10.56217026
92MAP3K60.55046581
93IRAK30.54991620
94CSNK1G10.53968816
95EIF2AK10.53560096
96SGK20.50730592
97STK380.49332216
98IKBKE0.48128649
99PDPK10.46922511
100CASK0.45144697
101PRKCQ0.44795330
102MAP2K10.44702712
103PRKCE0.44616155
104CSF1R0.44590227
105CSNK1E0.43588897
106CAMKK20.43251761
107GRK10.42331623
108PRKCG0.42008175
109MAP3K50.41130694
110CDK40.40335740
111MAPK30.39533947
112TAOK20.39253510
113IGF1R0.37471310
114MTOR0.37044368
115LATS20.36778815
116CAMK40.36245037
117MAPK100.36227348
118PAK30.35675016
119SGK2230.34976695
120SGK4940.34976695
121EGFR0.34587566
122RET0.34173717
123PKN10.33775561
124MAP2K20.33191079
125CSNK1G30.32707911
126EPHA40.32516935
127PBK0.31647763
128CSNK1G20.30418849
129IRAK10.27805351
130AKT30.26222652
131CSNK1A1L0.25743328
132PRKCA0.24765971
133BMX0.23038571
134MAP3K10.22225446
135PDK10.21999787
136ABL10.21524741
137MAP3K130.20954611
138IRAK20.19581142

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.56278693
2Nitrogen metabolism_Homo sapiens_hsa009103.45395556
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.38781146
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.38045967
5Arginine biosynthesis_Homo sapiens_hsa002203.07156289
6Complement and coagulation cascades_Homo sapiens_hsa046102.88767544
7Tryptophan metabolism_Homo sapiens_hsa003802.65352326
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.62482474
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.57752602
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.53988294
11Fatty acid degradation_Homo sapiens_hsa000712.45443489
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.33798506
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.31163524
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.22692221
15Butanoate metabolism_Homo sapiens_hsa006502.10858353
16Peroxisome_Homo sapiens_hsa041462.04508612
17Chemical carcinogenesis_Homo sapiens_hsa052042.03774583
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.02801051
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.99067628
20Histidine metabolism_Homo sapiens_hsa003401.92529087
21Propanoate metabolism_Homo sapiens_hsa006401.87696949
22PPAR signaling pathway_Homo sapiens_hsa033201.82665608
23Staphylococcus aureus infection_Homo sapiens_hsa051501.81804257
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.79962083
25Caffeine metabolism_Homo sapiens_hsa002321.75866653
26Fatty acid metabolism_Homo sapiens_hsa012121.74131356
27Retinol metabolism_Homo sapiens_hsa008301.73460442
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.72773942
29beta-Alanine metabolism_Homo sapiens_hsa004101.71815819
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65593032
31Phenylalanine metabolism_Homo sapiens_hsa003601.59145888
32Selenocompound metabolism_Homo sapiens_hsa004501.58635903
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53919538
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52202805
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52019137
36Bile secretion_Homo sapiens_hsa049761.50976961
37Tyrosine metabolism_Homo sapiens_hsa003501.48950134
38Sulfur metabolism_Homo sapiens_hsa009201.39810283
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.35057079
40Pyruvate metabolism_Homo sapiens_hsa006201.33698336
41Starch and sucrose metabolism_Homo sapiens_hsa005001.28981918
42Fatty acid elongation_Homo sapiens_hsa000621.24396353
43Folate biosynthesis_Homo sapiens_hsa007901.23167995
44Steroid biosynthesis_Homo sapiens_hsa001001.21133324
45Biosynthesis of amino acids_Homo sapiens_hsa012301.19946062
46ABC transporters_Homo sapiens_hsa020101.18477707
47Fat digestion and absorption_Homo sapiens_hsa049751.14893598
48Carbon metabolism_Homo sapiens_hsa012001.09857298
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06731111
50Sulfur relay system_Homo sapiens_hsa041221.03680843
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.00357765
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98759269
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.97899710
54Arginine and proline metabolism_Homo sapiens_hsa003300.95893595
55Vitamin B6 metabolism_Homo sapiens_hsa007500.95293044
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87691470
57Vitamin digestion and absorption_Homo sapiens_hsa049770.83512724
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83045651
59Lysine degradation_Homo sapiens_hsa003100.77319508
60One carbon pool by folate_Homo sapiens_hsa006700.77034309
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72540566
62Glutathione metabolism_Homo sapiens_hsa004800.69917985
63Glycerolipid metabolism_Homo sapiens_hsa005610.64117825
64Pentose phosphate pathway_Homo sapiens_hsa000300.56754634
65Fatty acid biosynthesis_Homo sapiens_hsa000610.51244227
66Metabolic pathways_Homo sapiens_hsa011000.45740845
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43421173
68Prion diseases_Homo sapiens_hsa050200.41151435
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34887026
70Pertussis_Homo sapiens_hsa051330.29396226
71Galactose metabolism_Homo sapiens_hsa000520.26153565
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24187438
73Linoleic acid metabolism_Homo sapiens_hsa005910.24093940
74Fructose and mannose metabolism_Homo sapiens_hsa000510.23540042
75Insulin resistance_Homo sapiens_hsa049310.22486705
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.20855005
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17614266
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.14498097
79Glucagon signaling pathway_Homo sapiens_hsa049220.09397389
80Other glycan degradation_Homo sapiens_hsa005110.09194322
81AMPK signaling pathway_Homo sapiens_hsa041520.01310704
82Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2421041
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.2307391
84Ether lipid metabolism_Homo sapiens_hsa00565-0.2288365
85Bladder cancer_Homo sapiens_hsa05219-0.2275150
86Amoebiasis_Homo sapiens_hsa05146-0.2268340
87Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2206552
88Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2175455
89Renin-angiotensin system_Homo sapiens_hsa04614-0.2052775
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2024936
91Type II diabetes mellitus_Homo sapiens_hsa04930-0.1961859
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1820817
93Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1693290
94Hepatitis C_Homo sapiens_hsa05160-0.1693273
95Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1632552
96Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1615692
97Regulation of autophagy_Homo sapiens_hsa04140-0.1519209
98African trypanosomiasis_Homo sapiens_hsa05143-0.1444748
99N-Glycan biosynthesis_Homo sapiens_hsa00510-0.1239847
100Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1205025
101Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1195344
102Insulin signaling pathway_Homo sapiens_hsa04910-0.1053351
103Sphingolipid metabolism_Homo sapiens_hsa00600-0.0829268
104Mineral absorption_Homo sapiens_hsa04978-0.0825645
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0812572
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0662195
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0523103
108Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0346777
109Serotonergic synapse_Homo sapiens_hsa04726-0.0051467

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