FEV

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the ETS transcription factor family. ETS family members have a highly conserved 85-amino acid ETS domain that binds purine-rich DNA sequences. The alanine-rich C-terminus of this gene indicates that it may act as a transcription repressor. This gene is exclusively expressed in neurons of the central serotonin (5-HT) system, a system implicated in the pathogeny of such psychiatric diseases as depression, anxiety, and eating disorders. In some types of Ewing tumors, this gene is fused to the Ewing sarcoma (EWS) gene following chromosome translocations. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1serotonin metabolic process (GO:0042428)9.59005573
2primary amino compound metabolic process (GO:1901160)7.91252437
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)6.46427092
4neuromuscular process controlling posture (GO:0050884)5.99563178
5COPI coating of Golgi vesicle (GO:0048205)5.57589673
6Golgi transport vesicle coating (GO:0048200)5.57589673
7positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003575.32506467
8insulin secretion (GO:0030073)5.14826187
9response to dietary excess (GO:0002021)4.70951649
10positive regulation of vesicle fusion (GO:0031340)4.70920910
11cellular ketone body metabolic process (GO:0046950)4.70837629
12monoamine transport (GO:0015844)4.65192536
13phenol-containing compound catabolic process (GO:0019336)4.53620028
14synaptic vesicle maturation (GO:0016188)4.50851713
15positive regulation of insulin secretion (GO:0032024)4.50197472
16glycerophospholipid catabolic process (GO:0046475)4.45658873
17toxin metabolic process (GO:0009404)4.45374739
18neurotransmitter uptake (GO:0001504)4.42776017
19peptide hormone processing (GO:0016486)4.39237324
20serotonin receptor signaling pathway (GO:0007210)4.37298548
21negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.36018950
22regulation of dopamine metabolic process (GO:0042053)4.35665151
23regulation of catecholamine metabolic process (GO:0042069)4.35665151
24indolalkylamine metabolic process (GO:0006586)4.20123289
25ketone body metabolic process (GO:1902224)4.14938469
26regulation of respiratory gaseous exchange by neurological system process (GO:0002087)4.12369303
27negative regulation of execution phase of apoptosis (GO:1900118)4.04007424
28endocrine pancreas development (GO:0031018)3.98746020
29regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.92658648
30peptide hormone secretion (GO:0030072)3.92282963
31nitric oxide biosynthetic process (GO:0006809)3.91480604
32synaptic vesicle exocytosis (GO:0016079)3.89638861
33negative regulation of synaptic transmission, GABAergic (GO:0032229)3.84828676
34cytochrome complex assembly (GO:0017004)3.81966590
35phenol-containing compound biosynthetic process (GO:0046189)3.79822785
36cellular response to glucagon stimulus (GO:0071377)3.79530618
37indole-containing compound metabolic process (GO:0042430)3.77442502
38peptide secretion (GO:0002790)3.76333862
39regulation of short-term neuronal synaptic plasticity (GO:0048172)3.76213645
40amine biosynthetic process (GO:0009309)3.75994907
41cellular biogenic amine biosynthetic process (GO:0042401)3.75994907
42regulation of vesicle fusion (GO:0031338)3.75837888
43L-alpha-amino acid transmembrane transport (GO:1902475)3.75774326
44respiratory chain complex IV assembly (GO:0008535)3.73533605
45regulation of calcium ion-dependent exocytosis (GO:0017158)3.72812813
46positive regulation of gluconeogenesis (GO:0045722)3.72379150
47thalamus development (GO:0021794)3.68291968
48glycine transport (GO:0015816)3.68173238
49behavioral response to nicotine (GO:0035095)3.67228483
50dopamine biosynthetic process (GO:0042416)3.64257844
51positive regulation of peptide hormone secretion (GO:0090277)3.63818332
52positive regulation of peptidyl-threonine phosphorylation (GO:0010800)3.63425460
53catecholamine transport (GO:0051937)3.59324593
54cellular response to lithium ion (GO:0071285)3.56373411
55negative regulation of cytosolic calcium ion concentration (GO:0051481)3.56024309
56response to parathyroid hormone (GO:0071107)3.54991852
57positive regulation of peptide secretion (GO:0002793)3.54587111
58retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.52823105
59potassium ion export (GO:0071435)3.52628832
60cerebellar Purkinje cell layer development (GO:0021680)3.52617735
61dopamine transport (GO:0015872)3.52313144
62positive regulation of histone H3-K4 methylation (GO:0051571)3.49901270
63response to pheromone (GO:0019236)3.49550968
64positive regulation of synaptic transmission, GABAergic (GO:0032230)3.47192082
65norepinephrine metabolic process (GO:0042415)3.46063241
66COPII vesicle coating (GO:0048208)3.42347739
67catechol-containing compound biosynthetic process (GO:0009713)3.42158662
68catecholamine biosynthetic process (GO:0042423)3.42158662
69righting reflex (GO:0060013)3.42018558
70auditory receptor cell differentiation (GO:0042491)3.41755434
71protein complex biogenesis (GO:0070271)3.40859406
72regulation of synaptic vesicle exocytosis (GO:2000300)3.36401741
73hormone secretion (GO:0046879)3.33995896
74maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.33470782
75regulation of insulin secretion (GO:0050796)3.32934568
76regulation of respiratory system process (GO:0044065)3.32237921
77activation of protein kinase A activity (GO:0034199)3.30544669
78regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)3.29801742
79inositol phosphate catabolic process (GO:0071545)3.27743762
80zinc ion homeostasis (GO:0055069)3.27235135
81startle response (GO:0001964)3.26222247
82brain morphogenesis (GO:0048854)3.25045397
83proline transport (GO:0015824)3.24864730
84toxin transport (GO:1901998)3.23810186
85positive regulation of amino acid transport (GO:0051957)3.22486263
86nephron epithelium morphogenesis (GO:0072088)3.22438136
87nephron tubule morphogenesis (GO:0072078)3.22438136
88glucosamine-containing compound catabolic process (GO:1901072)3.21644217
89RNA destabilization (GO:0050779)3.21033614
90regulation of dopamine secretion (GO:0014059)3.19336622
91epithelial cell fate commitment (GO:0072148)3.17890085
92hormone transport (GO:0009914)3.15899082
93negative regulation of JUN kinase activity (GO:0043508)3.15665180
94negative regulation of microtubule polymerization (GO:0031115)3.12547725
95signal release (GO:0023061)3.11795403
96protein retention in ER lumen (GO:0006621)3.11511214
97neurotransmitter secretion (GO:0007269)3.11076974
98polyol catabolic process (GO:0046174)3.10258893
99positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.07546549
100inositol phosphate dephosphorylation (GO:0046855)3.07399764
101phosphorylated carbohydrate dephosphorylation (GO:0046838)3.07399764
102glandular epithelial cell differentiation (GO:0002067)3.07208365
103vasoconstriction (GO:0042310)3.06804424
104exploration behavior (GO:0035640)3.06569457
105regulation of synaptic vesicle transport (GO:1902803)3.06295397
106neurotransmitter transport (GO:0006836)3.06107247
107signal peptide processing (GO:0006465)3.04247856
108regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.04113196
109regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.04113196
110regulation of neurotransmitter levels (GO:0001505)3.02647946
111drinking behavior (GO:0042756)3.02513681
112type B pancreatic cell development (GO:0003323)3.02474761
113mitochondrial respiratory chain complex assembly (GO:0033108)3.00538398
114regulation of peptide hormone secretion (GO:0090276)3.00407908
115regulation of synaptic transmission, dopaminergic (GO:0032225)3.00344958
116positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.00227247
117dopaminergic neuron differentiation (GO:0071542)2.98802158
118positive regulation of transcription regulatory region DNA binding (GO:2000679)2.98190347
119membrane repolarization during action potential (GO:0086011)2.96271222
120peptide transport (GO:0015833)2.95951380
121regulation of peptide secretion (GO:0002791)2.95543624
122negative regulation of glycogen metabolic process (GO:0070874)2.94905939
123regulation of mitochondrial translation (GO:0070129)2.94518141
124atrial cardiac muscle cell action potential (GO:0086014)2.93334713
125regulation of heart rate by cardiac conduction (GO:0086091)2.92379769
126inner ear receptor cell differentiation (GO:0060113)2.92223462
127regulation of synapse structural plasticity (GO:0051823)2.91984884
128water-soluble vitamin biosynthetic process (GO:0042364)2.91620948
129regulation of autophagic vacuole assembly (GO:2000785)2.91061043
130membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.90553002
131detection of calcium ion (GO:0005513)2.88743779
132regulation of neurotransmitter uptake (GO:0051580)2.88686539
133positive regulation of calcium ion import (GO:0090280)2.87587121
134neuron cell-cell adhesion (GO:0007158)2.87390037
135peptidyl-cysteine modification (GO:0018198)2.85189813
136regulation of type B pancreatic cell apoptotic process (GO:2000674)2.85154911
137regulation of glucokinase activity (GO:0033131)2.84894994
138regulation of hexokinase activity (GO:1903299)2.84894994
139vocalization behavior (GO:0071625)2.84690253
140innervation (GO:0060384)2.83543228
141nodal signaling pathway (GO:0038092)2.83395155
142dopamine metabolic process (GO:0042417)2.82759729
143nitric oxide mediated signal transduction (GO:0007263)2.80789452
144cerebellar Purkinje cell differentiation (GO:0021702)2.80646953
145cellular zinc ion homeostasis (GO:0006882)2.80612522
146suckling behavior (GO:0001967)2.79888696
147vesicle coating (GO:0006901)2.79183782
148negative regulation of digestive system process (GO:0060457)2.78628563
149positive regulation of exocytosis (GO:0045921)2.77617931
150neurotransmitter catabolic process (GO:0042135)2.77214360
151somite rostral/caudal axis specification (GO:0032525)2.76414843
152dendritic spine morphogenesis (GO:0060997)2.76294310
153response to glucagon (GO:0033762)2.75679171
154positive regulation of hormone secretion (GO:0046887)2.74789100
155positive regulation of amine transport (GO:0051954)2.71062036
156* neuron fate specification (GO:0048665)2.70113975
157positive regulation of catecholamine secretion (GO:0033605)2.70029729
158pteridine-containing compound biosynthetic process (GO:0042559)2.66782761
159regulation of cardioblast proliferation (GO:0003264)2.63741334
160regulation of secondary heart field cardioblast proliferation (GO:0003266)2.63741334
161renal tubule morphogenesis (GO:0061333)2.61228721
162cardiac left ventricle morphogenesis (GO:0003214)2.59297059
163basic amino acid transport (GO:0015802)2.57834291
164regulation of histone H3-K4 methylation (GO:0051569)2.55751654
165response to mineralocorticoid (GO:0051385)2.55741369
166regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.55715507
167cardiac conduction (GO:0061337)2.55254393
168C-terminal protein lipidation (GO:0006501)2.54780193
169positive regulation of neurotransmitter transport (GO:0051590)2.53660903

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.43436594
2EZH2_22144423_ChIP-Seq_EOC_Human5.19184460
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.18814366
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.13729235
5GBX2_23144817_ChIP-Seq_PC3_Human2.74546395
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.71058629
7CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.63841318
8* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.60813091
9SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.49314301
10REST_21632747_ChIP-Seq_MESCs_Mouse2.46772651
11ZNF274_21170338_ChIP-Seq_K562_Hela2.42959207
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.33277940
13PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.30608498
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.29841806
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.28601364
16* EZH2_27304074_Chip-Seq_ESCs_Mouse2.28565502
17TAF15_26573619_Chip-Seq_HEK293_Human2.26652865
18VDR_22108803_ChIP-Seq_LS180_Human2.22863942
19* REST_18959480_ChIP-ChIP_MESCs_Mouse2.22634165
20* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.18222973
21* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.17384413
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.15938682
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.15048498
24* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.07344449
25NR3C1_23031785_ChIP-Seq_PC12_Mouse2.05409853
26* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.03266364
27* EZH2_27294783_Chip-Seq_ESCs_Mouse2.02905934
28FLI1_27457419_Chip-Seq_LIVER_Mouse2.01057315
29* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.98711529
30* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.95275889
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.86851113
32IGF1R_20145208_ChIP-Seq_DFB_Human1.78219928
33* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.77496985
34* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.77496985
35OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.76865100
36RNF2_27304074_Chip-Seq_NSC_Mouse1.76568273
37DROSHA_22980978_ChIP-Seq_HELA_Human1.75524012
38HTT_18923047_ChIP-ChIP_STHdh_Human1.62560349
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.60556600
40P300_19829295_ChIP-Seq_ESCs_Human1.60477367
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60278968
42EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.56104492
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.54920937
44SMAD4_21799915_ChIP-Seq_A2780_Human1.52499055
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.48849429
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.47370339
47DNAJC2_21179169_ChIP-ChIP_NT2_Human1.47168082
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46754278
49CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.44145536
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44071776
51FOXA1_25329375_ChIP-Seq_VCAP_Human1.43233752
52FOXA1_27270436_Chip-Seq_PROSTATE_Human1.43233752
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42829073
54* CBX2_27304074_Chip-Seq_ESCs_Mouse1.41408980
55GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.40974505
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.40517586
57CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.39827266
58* RNF2_27304074_Chip-Seq_ESCs_Mouse1.38116420
59HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.36547631
60REST_19997604_ChIP-ChIP_NEURONS_Mouse1.35718590
61STAT3_23295773_ChIP-Seq_U87_Human1.35674215
62* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.32912461
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32051607
64CBP_20019798_ChIP-Seq_JUKART_Human1.32051607
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31523379
66SOX2_21211035_ChIP-Seq_LN229_Gbm1.30659605
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29989695
68NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.28689063
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26424910
70* NANOG_18555785_Chip-Seq_ESCs_Mouse1.26385044
71RARB_27405468_Chip-Seq_BRAIN_Mouse1.25110774
72OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21208972
73DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.20899763
74* EED_16625203_ChIP-ChIP_MESCs_Mouse1.20418685
75* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18628130
76AR_19668381_ChIP-Seq_PC3_Human1.18154112
77RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.18091388
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15917129
79SALL1_21062744_ChIP-ChIP_HESCs_Human1.15569796
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12490127
81* RING1B_27294783_Chip-Seq_ESCs_Mouse1.12107090
82NANOG_19829295_ChIP-Seq_ESCs_Human1.11904521
83SOX2_19829295_ChIP-Seq_ESCs_Human1.11904521
84FUS_26573619_Chip-Seq_HEK293_Human1.11357966
85TAL1_26923725_Chip-Seq_HPCs_Mouse1.10785191
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10780635
87KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10366314
88STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08533234
89LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07822342
90* P53_22387025_ChIP-Seq_ESCs_Mouse1.05625374
91CDX2_22108803_ChIP-Seq_LS180_Human1.04156378
92YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04041206
93* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04025853
94CMYC_18555785_Chip-Seq_ESCs_Mouse1.03567195
95FLI1_21867929_ChIP-Seq_TH2_Mouse1.03399128
96TCF4_22108803_ChIP-Seq_LS180_Human1.03156975
97E2F1_18555785_Chip-Seq_ESCs_Mouse1.02797272
98ER_23166858_ChIP-Seq_MCF-7_Human1.01401824
99E2F1_17053090_ChIP-ChIP_MCF-7_Human1.00582909
100* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00452542
101BP1_19119308_ChIP-ChIP_Hs578T_Human1.00085114
102SMAD4_21741376_ChIP-Seq_HESCs_Human0.99891278
103* SMAD3_21741376_ChIP-Seq_ESCs_Human0.99879473
104FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99796049
105RUNX2_22187159_ChIP-Seq_PCA_Human0.99682856
106NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99180567
107HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.97803677
108FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97255799
109RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96501942
110TBL1_22424771_ChIP-Seq_293T_Human0.96281189
111SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96127618
112* SOX2_18555785_Chip-Seq_ESCs_Mouse0.95880149
113NCOR_22424771_ChIP-Seq_293T_Human0.95597149
114ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95493568
115AR_25329375_ChIP-Seq_VCAP_Human0.94553483
116STAT3_18555785_Chip-Seq_ESCs_Mouse0.94374859
117EWS_26573619_Chip-Seq_HEK293_Human0.94357550
118* SMAD4_21741376_ChIP-Seq_EPCs_Human0.94081087
119TP53_22573176_ChIP-Seq_HFKS_Human0.94049885
120ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.93800105
121* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93153607
122AR_20517297_ChIP-Seq_VCAP_Human0.92798541
123CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92352767
124IRF1_19129219_ChIP-ChIP_H3396_Human0.92134536
125* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92010781
126TCF4_23295773_ChIP-Seq_U87_Human0.90428234
127BCAT_22108803_ChIP-Seq_LS180_Human0.89684181
128SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89424980
129SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.87360524
130WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87220182
131* PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.86051776
132RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.85254196
133SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83806476
134SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.82495477
135TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.81906485
136AR_21572438_ChIP-Seq_LNCaP_Human0.79779253
137SRY_22984422_ChIP-ChIP_TESTIS_Rat0.79382470
138CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78974128
139SMAD3_21741376_ChIP-Seq_EPCs_Human0.78889043
140AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.77333243

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005645_abnormal_hypothalamus_physiol6.77617776
2MP0003122_maternal_imprinting5.84649837
3MP0000013_abnormal_adipose_tissue4.47475364
4MP0006276_abnormal_autonomic_nervous4.34211783
5MP0003123_paternal_imprinting3.70118695
6MP0002139_abnormal_hepatobiliary_system3.24458144
7MP0001501_abnormal_sleep_pattern3.18617953
8MP0002909_abnormal_adrenal_gland3.17971109
9MP0003787_abnormal_imprinting2.96700547
10MP0003183_abnormal_peptide_metabolism2.89257231
11MP0002837_dystrophic_cardiac_calcinosis2.72087066
12MP0003121_genomic_imprinting2.67530452
13MP0002822_catalepsy2.53540289
14MP0009046_muscle_twitch2.31538606
15MP0000003_abnormal_adipose_tissue2.23084156
16MP0004270_analgesia2.21961416
17MP0003195_calcinosis2.15545125
18MP0005379_endocrine/exocrine_gland_phen2.12106479
19MP0001944_abnormal_pancreas_morphology2.08064324
20MP0002877_abnormal_melanocyte_morpholog1.87961545
21* MP0002572_abnormal_emotion/affect_behav1.87205616
22MP0002733_abnormal_thermal_nociception1.86196288
23MP0005174_abnormal_tail_pigmentation1.83775950
24MP0005423_abnormal_somatic_nervous1.81274359
25MP0001502_abnormal_circadian_rhythm1.78339142
26MP0002693_abnormal_pancreas_physiology1.76197504
27MP0000015_abnormal_ear_pigmentation1.73141957
28MP0003283_abnormal_digestive_organ1.72061208
29MP0003635_abnormal_synaptic_transmissio1.70151786
30MP0004019_abnormal_vitamin_homeostasis1.68649653
31MP0002254_reproductive_system_inflammat1.65104263
32MP0010386_abnormal_urinary_bladder1.63108180
33MP0008877_abnormal_DNA_methylation1.63032500
34MP0006072_abnormal_retinal_apoptosis1.61351509
35MP0005535_abnormal_body_temperature1.58128752
36MP0004147_increased_porphyrin_level1.56464391
37MP0002638_abnormal_pupillary_reflex1.56018773
38MP0003959_abnormal_lean_body1.54762834
39MP0005084_abnormal_gallbladder_morpholo1.52811947
40MP0001968_abnormal_touch/_nociception1.50765962
41MP0000569_abnormal_digit_pigmentation1.49530605
42MP0000372_irregular_coat_pigmentation1.45383386
43MP0002734_abnormal_mechanical_nocicepti1.44386344
44* MP0002272_abnormal_nervous_system1.41419757
45* MP0002557_abnormal_social/conspecific_i1.39181229
46MP0005253_abnormal_eye_physiology1.38987370
47MP0002064_seizures1.37005505
48MP0003646_muscle_fatigue1.36907321
49MP0000631_abnormal_neuroendocrine_gland1.35993077
50MP0009745_abnormal_behavioral_response1.35375297
51MP0010329_abnormal_lipoprotein_level1.34977586
52MP0002876_abnormal_thyroid_physiology1.33111935
53MP0005332_abnormal_amino_acid1.33107269
54MP0003011_delayed_dark_adaptation1.30204618
55MP0002009_preneoplasia1.30153237
56MP0008995_early_reproductive_senescence1.30096712
57MP0002751_abnormal_autonomic_nervous1.29472153
58MP0008872_abnormal_physiological_respon1.28736769
59MP0002063_abnormal_learning/memory/cond1.28608150
60MP0002078_abnormal_glucose_homeostasis1.27950382
61MP0004043_abnormal_pH_regulation1.26358199
62MP0005646_abnormal_pituitary_gland1.25095400
63* MP0002184_abnormal_innervation1.24825502
64MP0002138_abnormal_hepatobiliary_system1.24116595
65MP0005220_abnormal_exocrine_pancreas1.23440934
66MP0004859_abnormal_synaptic_plasticity1.23095329
67MP0005367_renal/urinary_system_phenotyp1.20500934
68MP0000516_abnormal_urinary_system1.20500934
69MP0010234_abnormal_vibrissa_follicle1.18335897
70MP0005551_abnormal_eye_electrophysiolog1.17598751
71MP0001188_hyperpigmentation1.16855728
72MP0003879_abnormal_hair_cell1.16066594
73* MP0003953_abnormal_hormone_level1.15120035
74MP0002928_abnormal_bile_duct1.13635393
75MP0005636_abnormal_mineral_homeostasis1.10161890
76MP0002736_abnormal_nociception_after1.10156275
77MP0002234_abnormal_pharynx_morphology1.09725764
78MP0002163_abnormal_gland_morphology1.08617001
79MP0001664_abnormal_digestion1.08140020
80MP0008775_abnormal_heart_ventricle1.07773905
81MP0000230_abnormal_systemic_arterial1.06647495
82MP0001529_abnormal_vocalization1.05335126
83MP0004233_abnormal_muscle_weight1.03641245
84MP0005409_darkened_coat_color1.03379628
85MP0009780_abnormal_chondrocyte_physiolo1.02004730
86MP0005386_behavior/neurological_phenoty1.01564908
87MP0004924_abnormal_behavior1.01564908
88MP0004142_abnormal_muscle_tone1.00563368
89MP0000678_abnormal_parathyroid_gland1.00063058
90MP0001984_abnormal_olfaction0.98817134
91MP0001756_abnormal_urination0.97257129
92MP0002938_white_spotting0.96729595
93MP0008961_abnormal_basal_metabolism0.93871208
94MP0001905_abnormal_dopamine_level0.93469710
95MP0005075_abnormal_melanosome_morpholog0.93276962
96MP0001970_abnormal_pain_threshold0.89533984
97MP0003172_abnormal_lysosome_physiology0.88937963
98MP0005503_abnormal_tendon_morphology0.88784907
99MP0001486_abnormal_startle_reflex0.87467010
100MP0000538_abnormal_urinary_bladder0.86628469
101MP0003890_abnormal_embryonic-extraembry0.84166988
102MP0005375_adipose_tissue_phenotype0.84095332
103MP0003880_abnormal_central_pattern0.82563791
104MP0003718_maternal_effect0.82519344
105MP0001765_abnormal_ion_homeostasis0.82507846
106MP0004085_abnormal_heartbeat0.81151311
107MP0006035_abnormal_mitochondrial_morpho0.80612839
108MP0001299_abnormal_eye_distance/0.79616265
109MP0003868_abnormal_feces_composition0.79537158
110MP0000462_abnormal_digestive_system0.78535814
111MP0000427_abnormal_hair_cycle0.77050946
112* MP0002066_abnormal_motor_capabilities/c0.76397710
113MP0004264_abnormal_extraembryonic_tissu0.76110536
114MP0010678_abnormal_skin_adnexa0.75924885
115MP0002229_neurodegeneration0.74799041
116MP0005085_abnormal_gallbladder_physiolo0.73211816
117MP0003806_abnormal_nucleotide_metabolis0.73206543
118MP0005448_abnormal_energy_balance0.72872328
119MP0004811_abnormal_neuron_physiology0.72617830
120* MP0002882_abnormal_neuron_morphology0.72081891
121MP0000955_abnormal_spinal_cord0.71095729
122MP0002118_abnormal_lipid_homeostasis0.70555512
123MP0000639_abnormal_adrenal_gland0.70473058
124MP0001986_abnormal_taste_sensitivity0.70331102
125MP0006036_abnormal_mitochondrial_physio0.69925041
126MP0002067_abnormal_sensory_capabilities0.69370649
127MP0001348_abnormal_lacrimal_gland0.69270265
128MP0004145_abnormal_muscle_electrophysio0.68065295
129MP0001440_abnormal_grooming_behavior0.67319253
130MP0005452_abnormal_adipose_tissue0.67317303
131MP0004133_heterotaxia0.65955658
132MP0002069_abnormal_eating/drinking_beha0.65371983
133MP0003119_abnormal_digestive_system0.63925749
134MP0005257_abnormal_intraocular_pressure0.60701573
135MP0004885_abnormal_endolymph0.57802219
136MP0003329_amyloid_beta_deposits0.54376035
137MP0005365_abnormal_bile_salt0.53096534
138MP0000778_abnormal_nervous_system0.50645621
139MP0008875_abnormal_xenobiotic_pharmacok0.49909179

Predicted human phenotypes

RankGene SetZ-score
1Elevated circulating parathyroid hormone (PTH) level (HP:0003165)7.68888421
2Abnormality of calcium-phosphate metabolism (HP:0100530)5.65465603
3Agitation (HP:0000713)5.56274960
4Hyperinsulinemic hypoglycemia (HP:0000825)5.24239061
5Intestinal atresia (HP:0011100)4.90695537
6Retinal atrophy (HP:0001105)4.70967961
7Hypoglycemic seizures (HP:0002173)4.49548437
8Hypothermia (HP:0002045)4.29329010
9Menstrual irregularities (HP:0000858)4.23397131
10Abnormality of aromatic amino acid family metabolism (HP:0004338)4.20731153
11Attenuation of retinal blood vessels (HP:0007843)4.09683683
12Pheochromocytoma (HP:0002666)4.06489814
13Limb hypertonia (HP:0002509)4.03660276
14Symptomatic seizures (HP:0011145)4.02866817
15Abnormality of vitamin B metabolism (HP:0004340)4.00145373
16Hyperglycemia (HP:0003074)3.96328693
17Bony spicule pigmentary retinopathy (HP:0007737)3.89376229
18Hypoglycemic coma (HP:0001325)3.83121189
19Ketoacidosis (HP:0001993)3.81899436
20Neuroendocrine neoplasm (HP:0100634)3.78465161
21Pancreatic islet-cell hyperplasia (HP:0004510)3.64738240
22Hypercortisolism (HP:0001578)3.52147972
23Abnormality of endocrine pancreas physiology (HP:0012093)3.49723350
24Abnormality of the pancreatic islet cells (HP:0006476)3.49723350
25Late onset (HP:0003584)3.48564752
26Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.41717260
27Hyperparathyroidism (HP:0000843)3.37081397
28Abnormality of vitamin metabolism (HP:0100508)3.33768941
29Limb dystonia (HP:0002451)3.31365160
30Methylmalonic acidemia (HP:0002912)3.21273208
31Hyperthyroidism (HP:0000836)3.20331256
32Urethral obstruction (HP:0000796)3.14488204
33Congenital malformation of the right heart (HP:0011723)3.12974510
34Double outlet right ventricle (HP:0001719)3.12974510
35Large for gestational age (HP:0001520)3.01452480
36Sex reversal (HP:0012245)2.98620258
37Abnormal sex determination (HP:0012244)2.98620258
38Anxiety (HP:0000739)2.98065692
39Macroorchidism (HP:0000053)2.97666201
40Postural tremor (HP:0002174)2.97116589
41Restlessness (HP:0000711)2.94817334
42Growth hormone excess (HP:0000845)2.93145490
43Progressive cerebellar ataxia (HP:0002073)2.92379104
44Aplasia/hypoplasia of the uterus (HP:0008684)2.88047695
45Visual hallucinations (HP:0002367)2.82983397
46Papilledema (HP:0001085)2.79798206
47Orthostatic hypotension (HP:0001278)2.78776029
48Glycosuria (HP:0003076)2.77680253
49Abnormality of urine glucose concentration (HP:0011016)2.77680253
50Hyperphosphatemia (HP:0002905)2.70898412
51Nephronophthisis (HP:0000090)2.67769022
52Hypsarrhythmia (HP:0002521)2.65911900
53Polyphagia (HP:0002591)2.64423761
54Methylmalonic aciduria (HP:0012120)2.64007955
55EEG with generalized epileptiform discharges (HP:0011198)2.63879730
56Abolished electroretinogram (ERG) (HP:0000550)2.61978469
57Gastrointestinal atresia (HP:0002589)2.55943869
58Epileptiform EEG discharges (HP:0011182)2.55333987
59Atelectasis (HP:0100750)2.55050693
60Dysautonomia (HP:0002459)2.52734297
61Severe visual impairment (HP:0001141)2.52464919
62Decreased activity of mitochondrial respiratory chain (HP:0008972)2.52453235
63Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.52453235
64Progressive neurologic deterioration (HP:0002344)2.50540738
65Hypoplasia of the uterus (HP:0000013)2.42376268
66Hypotension (HP:0002615)2.40306672
67Hemiparesis (HP:0001269)2.37849222
68Abnormality of the vitamin B12 metabolism (HP:0004341)2.36017234
69Insulin-resistant diabetes mellitus (HP:0000831)2.34476535
70Albinism (HP:0001022)2.34397127
71Congenital stationary night blindness (HP:0007642)2.29870685
72Ketosis (HP:0001946)2.29634173
73Cortical visual impairment (HP:0100704)2.29185764
74Pancreatic fibrosis (HP:0100732)2.28679383
75Enlarged penis (HP:0000040)2.28094421
76Progressive macrocephaly (HP:0004481)2.26604073
77Dysostosis multiplex (HP:0000943)2.26522740
78Abnormal mitochondria in muscle tissue (HP:0008316)2.26178670
793-Methylglutaconic aciduria (HP:0003535)2.24818171
80Abnormal pupillary function (HP:0007686)2.24351058
81Polydipsia (HP:0001959)2.19858989
82Abnormal drinking behavior (HP:0030082)2.19858989
83Abnormal pancreas size (HP:0012094)2.19850401
84Blue irides (HP:0000635)2.19161264
85Pancreatic cysts (HP:0001737)2.16811367
86Akinesia (HP:0002304)2.16563558
87Abnormal albumin level (HP:0012116)2.15711883
88Hypoalbuminemia (HP:0003073)2.15711883
89Unilateral renal agenesis (HP:0000122)2.15480975
90Testicular neoplasm (HP:0010788)2.15477747
91Mucopolysacchariduria (HP:0008155)2.14776962
92Urinary glycosaminoglycan excretion (HP:0003541)2.14776962
93Generalized hyperpigmentation (HP:0007440)2.13275081
94Osteomalacia (HP:0002749)2.12433746
95Acute necrotizing encephalopathy (HP:0006965)2.11872333
96Choreoathetosis (HP:0001266)2.11115943
97Psychosis (HP:0000709)2.08005220
98Adrenal overactivity (HP:0002717)2.07738689
99Neoplasm of the peripheral nervous system (HP:0100007)2.07664861
100Papillary thyroid carcinoma (HP:0002895)2.07446303
101Focal seizures (HP:0007359)2.07170195
102Ankle clonus (HP:0011448)2.06316819
103Gout (HP:0001997)2.06256282
104Absence seizures (HP:0002121)2.05971075
105Striae distensae (HP:0001065)2.04867673
106Abnormality of the renal medulla (HP:0100957)2.04503163
107Poor suck (HP:0002033)2.03870124
108Abnormality of the renal cortex (HP:0011035)2.03604894
109Abnormality of the right ventricle (HP:0001707)2.02723787
110Hyperventilation (HP:0002883)2.00892928
111Lipid accumulation in hepatocytes (HP:0006561)2.00718433
112Failure to thrive in infancy (HP:0001531)2.00603164
113Heterochromia iridis (HP:0001100)1.99610423
114Atonic seizures (HP:0010819)1.99310150
115Optic disc pallor (HP:0000543)1.97939634
116Generalized tonic-clonic seizures (HP:0002069)1.96891064
117Increased hepatocellular lipid droplets (HP:0006565)1.96767969
118Abnormality of mucopolysaccharide metabolism (HP:0011020)1.96329504
119Abnormality of polysaccharide metabolism (HP:0011012)1.96329504
120Abnormality of glycosaminoglycan metabolism (HP:0004371)1.96329504
121Molar tooth sign on MRI (HP:0002419)1.96168680
122Abnormality of midbrain morphology (HP:0002418)1.96168680
123Fetal akinesia sequence (HP:0001989)1.96078825
124Hypophosphatemia (HP:0002148)1.95852203
125Depression (HP:0000716)1.95674636
126Mitochondrial inheritance (HP:0001427)1.93863888
127Furrowed tongue (HP:0000221)1.90880514
128Bifid tongue (HP:0010297)1.89986661
129Abnormality of homocysteine metabolism (HP:0010919)1.89804545
130Homocystinuria (HP:0002156)1.89804545
131Renal Fanconi syndrome (HP:0001994)1.88922761
132Diminished movement (HP:0002374)1.88371917
133Hypocalcemia (HP:0002901)1.87398754
134Abnormal EKG (HP:0003115)1.87040218
135Genetic anticipation (HP:0003743)1.85861930
136Action tremor (HP:0002345)1.85778928
137Hyperphosphaturia (HP:0003109)1.84806133
138Severe muscular hypotonia (HP:0006829)1.83493397
139Muscular hypotonia of the trunk (HP:0008936)1.83344456
140Neoplasm of the heart (HP:0100544)1.82381192
141Myokymia (HP:0002411)1.80832760
142Progressive inability to walk (HP:0002505)1.79933697
143Torticollis (HP:0000473)1.79758603
144Hypoventilation (HP:0002791)1.79651026
145Abnormal rod and cone electroretinograms (HP:0008323)1.79508983
146Vacuolated lymphocytes (HP:0001922)1.78686673
147Proximal tubulopathy (HP:0000114)1.78273976
148Hepatoblastoma (HP:0002884)1.77787856
149Congenital sensorineural hearing impairment (HP:0008527)1.77196577
150Tachypnea (HP:0002789)1.77014036
151Oligodactyly (hands) (HP:0001180)1.76589444
152Palpitations (HP:0001962)1.76396069
153Septate vagina (HP:0001153)1.75850920
154Generalized hypopigmentation (HP:0007513)1.74858467
155Prolonged QT interval (HP:0001657)1.72970276
156Insulin resistance (HP:0000855)1.69763073
157Glucose intolerance (HP:0000833)1.69133982
158Increased circulating renin level (HP:0000848)1.68769886
159Chronic hepatic failure (HP:0100626)1.68653271
160Anteriorly placed anus (HP:0001545)1.67906170
161Concave nail (HP:0001598)1.67727902
162Nuclear cataract (HP:0100018)1.67358045
163Increased CSF protein (HP:0002922)1.67239618
164Congenital glaucoma (HP:0001087)1.66773103
165Hypokalemia (HP:0002900)1.66745209
166Neoplasm of the thyroid gland (HP:0100031)1.65613142
167Dialeptic seizures (HP:0011146)1.64711781

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK38.37969157
2MAPK156.92675084
3PIK3CG4.11027962
4NTRK33.91218870
5MAP4K23.37023669
6MAP2K63.20368764
7MST42.97427230
8UHMK12.97285809
9WNK42.91827484
10PINK12.90322295
11MAP3K92.69161185
12PHKG22.56904095
13PHKG12.56904095
14GRK12.56022206
15ADRBK22.38955142
16FGFR22.33485508
17INSRR2.29123878
18MKNK21.87268906
19GRK71.84089092
20PAK31.82409645
21FGFR31.81705569
22PNCK1.68741039
23MARK11.62672586
24NTRK21.59240871
25MAP3K41.57550712
26MAP3K61.54547633
27PASK1.50108668
28CDK81.50060093
29DYRK1B1.42515443
30STK38L1.39075394
31HIPK21.34720826
32CSNK1G31.26004220
33MAP3K21.22558898
34ARAF1.21033903
35TRPM71.20731973
36CSNK1G21.19281443
37MAP2K71.17363617
38MAP3K121.17050208
39DYRK21.11117387
40WNK11.09973755
41CAMK2A1.08815855
42MAPK131.07534585
43PAK61.06346248
44MAP2K31.06313356
45FRK1.01909869
46MINK11.00924349
47CSNK1G10.95480717
48KSR20.92664434
49TRIM280.92055823
50YES10.90961021
51EPHA30.90390566
52LMTK20.90389461
53DAPK20.90271790
54PLK20.87379490
55ACVR1B0.86701135
56CAMK1G0.84353686
57PRKCI0.83805473
58PTK2B0.80240392
59TAF10.79115182
60ALK0.78444478
61CDC42BPA0.76424615
62MAP2K40.76333522
63MAP3K130.74110408
64DAPK10.73241159
65EIF2AK10.71318070
66BCKDK0.69126309
67MAP3K10.68962361
68SCYL20.68521437
69TAOK10.67791978
70CDK190.66282688
71LIMK10.63008551
72STK110.61651218
73MAPK90.60878812
74CDK50.60715816
75FER0.59709298
76IRAK20.59614200
77CAMKK20.58480218
78CSNK1A1L0.58372799
79ADRBK10.58119770
80NEK10.56165482
81NTRK10.56091331
82PRKCG0.55642733
83MKNK10.55215735
84TAOK30.54595712
85BRAF0.54543947
86KSR10.53742879
87NLK0.53634400
88MAP3K50.51994913
89PRKCZ0.50920365
90DYRK1A0.50534650
91PRKCH0.49986379
92ERBB30.49780393
93IRAK10.48984261
94NME10.47259868
95CAMK2D0.47150791
96STK240.45052952
97GRK50.44669911
98CASK0.44608243
99TLK10.44298209
100PRKG10.44218069
101CSNK1A10.43490985
102CAMK1D0.43321574
103RPS6KA50.42190595
104PRKD20.42068891
105AKT30.41412271
106CDK140.40400906
107FLT30.40143018
108MARK20.40130254
109PRKD30.39972254
110FGFR10.38977222
111TESK10.38800053
112PRKACA0.37946115
113DYRK30.37734020
114RIPK40.36037843
115ZAP700.35623314
116BMPR20.34794478
117SGK10.33904346
118CAMK2B0.33643334
119PRKACB0.32722139
120CHUK0.32261667
121RPS6KA30.31781707
122CAMK2G0.31258841
123ERBB40.29863451
124PRKACG0.29671276
125OXSR10.29588611
126PRKCA0.28990392
127GSK3A0.28899152
128STK380.28746809
129CAMK10.27462489
130RET0.26737027
131PTK20.26689165
132MOS0.26313613
133MAPK100.24866774
134EPHA20.24618131
135CDK11A0.24385173
136CSK0.23286738
137CDK150.22589011
138CDK180.22502375
139EPHB10.22416622
140CSNK1E0.21970032
141PRKAA10.21932761
142BMPR1B0.20193382
143PRKCE0.20183493
144PRKG20.19317907
145MTOR0.19219895
146LATS20.19216853

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.76896603
2Insulin secretion_Homo sapiens_hsa049113.80809780
3Protein export_Homo sapiens_hsa030603.68855128
4Serotonergic synapse_Homo sapiens_hsa047263.19941432
5Cocaine addiction_Homo sapiens_hsa050303.00264783
6Amphetamine addiction_Homo sapiens_hsa050312.55235681
7Vibrio cholerae infection_Homo sapiens_hsa051102.45909571
8Synaptic vesicle cycle_Homo sapiens_hsa047212.44203125
9Tryptophan metabolism_Homo sapiens_hsa003802.42723557
10Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.31114417
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.30405452
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.29564432
13GABAergic synapse_Homo sapiens_hsa047272.15588129
14Selenocompound metabolism_Homo sapiens_hsa004502.11750392
15Phototransduction_Homo sapiens_hsa047442.11017344
16Dopaminergic synapse_Homo sapiens_hsa047282.02609464
17Phenylalanine metabolism_Homo sapiens_hsa003601.88157569
18Circadian entrainment_Homo sapiens_hsa047131.85007735
19Type II diabetes mellitus_Homo sapiens_hsa049301.81688417
20Nicotine addiction_Homo sapiens_hsa050331.71310566
21Type I diabetes mellitus_Homo sapiens_hsa049401.65045905
22Glutathione metabolism_Homo sapiens_hsa004801.53186899
23Taste transduction_Homo sapiens_hsa047421.52682332
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.51057905
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.47042573
26Thyroid hormone synthesis_Homo sapiens_hsa049181.37707148
27Tyrosine metabolism_Homo sapiens_hsa003501.37495358
28Morphine addiction_Homo sapiens_hsa050321.37448055
29Glutamatergic synapse_Homo sapiens_hsa047241.32075295
30Vitamin B6 metabolism_Homo sapiens_hsa007501.29302383
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29174514
32Salivary secretion_Homo sapiens_hsa049701.27985984
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.27445804
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.25374775
35Folate biosynthesis_Homo sapiens_hsa007901.20777585
36Prion diseases_Homo sapiens_hsa050201.20742437
37Long-term depression_Homo sapiens_hsa047301.18205256
38Renin secretion_Homo sapiens_hsa049241.17614048
39Histidine metabolism_Homo sapiens_hsa003401.16810598
40Cholinergic synapse_Homo sapiens_hsa047251.15472378
41Sulfur metabolism_Homo sapiens_hsa009201.14797954
42Estrogen signaling pathway_Homo sapiens_hsa049151.13146971
43Long-term potentiation_Homo sapiens_hsa047201.12826204
44Peroxisome_Homo sapiens_hsa041461.10646442
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.10283845
46RNA polymerase_Homo sapiens_hsa030201.03931300
47Gastric acid secretion_Homo sapiens_hsa049711.01584603
48Glucagon signaling pathway_Homo sapiens_hsa049221.01459657
49Butanoate metabolism_Homo sapiens_hsa006501.01457811
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.01236328
51Mineral absorption_Homo sapiens_hsa049781.01029478
52Nitrogen metabolism_Homo sapiens_hsa009101.00973081
53Vitamin digestion and absorption_Homo sapiens_hsa049771.00126553
54Linoleic acid metabolism_Homo sapiens_hsa005910.99892272
55Arginine biosynthesis_Homo sapiens_hsa002200.98980364
56Gap junction_Homo sapiens_hsa045400.96192977
57Sphingolipid metabolism_Homo sapiens_hsa006000.96139181
58Propanoate metabolism_Homo sapiens_hsa006400.95812619
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94662597
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94141945
61Alcoholism_Homo sapiens_hsa050340.93023843
62Oxidative phosphorylation_Homo sapiens_hsa001900.92386972
63Pancreatic secretion_Homo sapiens_hsa049720.91958863
64Chemical carcinogenesis_Homo sapiens_hsa052040.91616373
65Parkinsons disease_Homo sapiens_hsa050120.89214261
66Caffeine metabolism_Homo sapiens_hsa002320.88465446
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.86488004
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86348863
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86062721
70Melanogenesis_Homo sapiens_hsa049160.85212272
71cAMP signaling pathway_Homo sapiens_hsa040240.83671154
72Oxytocin signaling pathway_Homo sapiens_hsa049210.83336916
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81087348
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81016972
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.80587843
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80196279
77Cardiac muscle contraction_Homo sapiens_hsa042600.79681411
78Collecting duct acid secretion_Homo sapiens_hsa049660.78689916
79Olfactory transduction_Homo sapiens_hsa047400.78198418
80Fatty acid elongation_Homo sapiens_hsa000620.77066250
81Regulation of autophagy_Homo sapiens_hsa041400.75727507
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.73845421
83Metabolic pathways_Homo sapiens_hsa011000.71543618
84GnRH signaling pathway_Homo sapiens_hsa049120.69745403
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69569260
86Retinol metabolism_Homo sapiens_hsa008300.68681629
87Alzheimers disease_Homo sapiens_hsa050100.68341353
88Circadian rhythm_Homo sapiens_hsa047100.68049365
89Fatty acid biosynthesis_Homo sapiens_hsa000610.67671930
90Other glycan degradation_Homo sapiens_hsa005110.65439820
91ABC transporters_Homo sapiens_hsa020100.63681604
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62564356
93Fatty acid metabolism_Homo sapiens_hsa012120.62394892
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61795275
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61064171
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58734162
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58692290
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.57769824
99N-Glycan biosynthesis_Homo sapiens_hsa005100.57089792
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56700491
101Huntingtons disease_Homo sapiens_hsa050160.53528889
102Basal transcription factors_Homo sapiens_hsa030220.52379797
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51755505
104Ovarian steroidogenesis_Homo sapiens_hsa049130.51289035
105Arachidonic acid metabolism_Homo sapiens_hsa005900.48593441
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46693538
107beta-Alanine metabolism_Homo sapiens_hsa004100.46572751
108Lysosome_Homo sapiens_hsa041420.44825418
109Dilated cardiomyopathy_Homo sapiens_hsa054140.44756472
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44752148
111Starch and sucrose metabolism_Homo sapiens_hsa005000.42491394
112Purine metabolism_Homo sapiens_hsa002300.42176656
113Axon guidance_Homo sapiens_hsa043600.42013107
114Calcium signaling pathway_Homo sapiens_hsa040200.41809874
115Steroid hormone biosynthesis_Homo sapiens_hsa001400.38993587
116Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38048798
117Dorso-ventral axis formation_Homo sapiens_hsa043200.36865533
118Bile secretion_Homo sapiens_hsa049760.36302931
119Insulin signaling pathway_Homo sapiens_hsa049100.34748298
120Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34568027
121Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33272129
122Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31680454
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30730536
124Choline metabolism in cancer_Homo sapiens_hsa052310.29309169
125ErbB signaling pathway_Homo sapiens_hsa040120.28513644
126Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27481596
127Phospholipase D signaling pathway_Homo sapiens_hsa040720.27247007
128Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25987104
129Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.25327501
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.24940244
131Renal cell carcinoma_Homo sapiens_hsa052110.24846616
132Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.24730487
133Ether lipid metabolism_Homo sapiens_hsa005650.23246059
134Wnt signaling pathway_Homo sapiens_hsa043100.23044343
135Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.19829804
136Fat digestion and absorption_Homo sapiens_hsa049750.19657456
137Oocyte meiosis_Homo sapiens_hsa041140.17858363
138MAPK signaling pathway_Homo sapiens_hsa040100.15951623
139Drug metabolism - other enzymes_Homo sapiens_hsa009830.15360377
140Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.14966915

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