FEZ1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)9.20232911
2central nervous system myelination (GO:0022010)9.20232911
3fatty acid elongation (GO:0030497)6.10251496
4pyrimidine nucleobase catabolic process (GO:0006208)5.76876079
5postsynaptic membrane organization (GO:0001941)5.75546454
6long-chain fatty acid biosynthetic process (GO:0042759)5.38088809
7myelination (GO:0042552)5.08778739
8axon ensheathment (GO:0008366)5.06665790
9ensheathment of neurons (GO:0007272)5.06665790
10nucleobase catabolic process (GO:0046113)4.67120725
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.57275816
12negative regulation of neurotransmitter transport (GO:0051589)4.50070068
13presynaptic membrane organization (GO:0097090)4.47476433
14neurotransmitter secretion (GO:0007269)4.32940117
15membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.27628534
16neuron cell-cell adhesion (GO:0007158)4.27169226
17regulation of synaptic vesicle transport (GO:1902803)4.22389275
18negative regulation of neurotransmitter secretion (GO:0046929)4.17741723
19neurotransmitter-gated ion channel clustering (GO:0072578)4.15322785
20presynaptic membrane assembly (GO:0097105)4.15266570
21regulation of synapse structural plasticity (GO:0051823)4.11308975
22negative regulation of protein localization to cell surface (GO:2000009)3.87119967
23cell migration in hindbrain (GO:0021535)3.87080513
24cholesterol biosynthetic process (GO:0006695)3.83967666
25regulation of collateral sprouting (GO:0048670)3.83856834
26myelin maintenance (GO:0043217)3.82162595
27locomotory exploration behavior (GO:0035641)3.81300113
28neuronal action potential propagation (GO:0019227)3.78615183
29auditory behavior (GO:0031223)3.78084783
30exploration behavior (GO:0035640)3.74025219
31cellular potassium ion homeostasis (GO:0030007)3.73915400
32regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.64840480
33apical protein localization (GO:0045176)3.64814763
34response to methylmercury (GO:0051597)3.60177320
35layer formation in cerebral cortex (GO:0021819)3.59412703
36oligodendrocyte differentiation (GO:0048709)3.58172393
37L-amino acid import (GO:0043092)3.50746505
38glycerophospholipid catabolic process (GO:0046475)3.48578476
39synapse assembly (GO:0007416)3.47186670
40neurotransmitter transport (GO:0006836)3.46001231
41sodium ion export (GO:0071436)3.44370923
42sterol biosynthetic process (GO:0016126)3.43498131
43glycosphingolipid biosynthetic process (GO:0006688)3.42872060
44synaptic vesicle endocytosis (GO:0048488)3.41914451
45adult walking behavior (GO:0007628)3.41477060
46regulation of neurotransmitter levels (GO:0001505)3.39217561
47synaptic vesicle exocytosis (GO:0016079)3.39198625
48response to auditory stimulus (GO:0010996)3.38234068
49substantia nigra development (GO:0021762)3.34728357
50regulation of glutamate receptor signaling pathway (GO:1900449)3.34658597
51negative regulation of synaptic transmission, GABAergic (GO:0032229)3.28222772
52neuron recognition (GO:0008038)3.27568370
53transmission of nerve impulse (GO:0019226)3.25038031
54cerebral cortex radially oriented cell migration (GO:0021799)3.24532357
55asymmetric protein localization (GO:0008105)3.23696093
56regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.22179413
57eye photoreceptor cell differentiation (GO:0001754)3.18903428
58photoreceptor cell differentiation (GO:0046530)3.18903428
59positive regulation of synapse maturation (GO:0090129)3.16727691
60synaptic vesicle maturation (GO:0016188)3.15926525
61regulation of neurotransmitter secretion (GO:0046928)3.14661332
62long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.12818868
63regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.12501772
64acidic amino acid transport (GO:0015800)3.12347945
65astrocyte development (GO:0014002)3.11974155
66positive regulation of membrane potential (GO:0045838)3.11544957
67long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.11540181
68positive regulation of oligodendrocyte differentiation (GO:0048714)3.11332555
69regulation of respiratory system process (GO:0044065)3.11004664
70negative regulation of axonogenesis (GO:0050771)3.09861353
71regulation of dendritic spine morphogenesis (GO:0061001)3.07872268
72protein localization to synapse (GO:0035418)3.07100972
73neurotransmitter uptake (GO:0001504)3.07075894
74regulation of synaptic transmission, glutamatergic (GO:0051966)3.06832305
75regulation of vesicle fusion (GO:0031338)3.06612522
76isoprenoid biosynthetic process (GO:0008299)3.06440867
77neuromuscular synaptic transmission (GO:0007274)3.05752476
78regulation of neurotransmitter transport (GO:0051588)3.02867763
79detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.02446234
80detection of temperature stimulus involved in sensory perception (GO:0050961)3.02446234
81ionotropic glutamate receptor signaling pathway (GO:0035235)3.02298942
82regulation of synaptic vesicle exocytosis (GO:2000300)3.01820300
83regulation of excitatory postsynaptic membrane potential (GO:0060079)3.00253556
84synapse organization (GO:0050808)2.98570676
85negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.98330796
86cerebellar granule cell differentiation (GO:0021707)2.97036992
87startle response (GO:0001964)2.95382990
88central nervous system projection neuron axonogenesis (GO:0021952)2.94179755
89protein neddylation (GO:0045116)2.93343372
90negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.91907347
91C4-dicarboxylate transport (GO:0015740)2.90743710
92regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.90290762
93vocalization behavior (GO:0071625)2.90234487
94G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.89685276
95establishment of synaptic vesicle localization (GO:0097480)2.88618759
96synaptic vesicle transport (GO:0048489)2.88618759
97dendritic spine morphogenesis (GO:0060997)2.88531145
98potassium ion homeostasis (GO:0055075)2.88323341
99positive regulation of dendritic spine development (GO:0060999)2.87165245
100positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.86796244
101glutamate secretion (GO:0014047)2.86720182
102regulation of long-term neuronal synaptic plasticity (GO:0048169)2.86217434
103regulation of postsynaptic membrane potential (GO:0060078)2.85808962
104regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.85745972
105axonal fasciculation (GO:0007413)2.85517060
106response to redox state (GO:0051775)2.84171907
107gamma-aminobutyric acid signaling pathway (GO:0007214)2.83257126
108creatine metabolic process (GO:0006600)2.82828740
109positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.82637500
110neuron-neuron synaptic transmission (GO:0007270)2.81790966
111cerebellar Purkinje cell differentiation (GO:0021702)2.81457244
112neuron remodeling (GO:0016322)2.81232085
113dendritic spine organization (GO:0097061)2.80784495
114positive regulation of dendritic spine morphogenesis (GO:0061003)2.80403556
115regulation of short-term neuronal synaptic plasticity (GO:0048172)2.80260534
116neuronal ion channel clustering (GO:0045161)2.79417536
117glutamate receptor signaling pathway (GO:0007215)2.78792629
118axon development (GO:0061564)2.78672490
119synaptic transmission, glutamatergic (GO:0035249)2.78086239
120calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.78061561
121regulation of voltage-gated calcium channel activity (GO:1901385)2.77970793
122regulation of synapse assembly (GO:0051963)2.77431131
123limb bud formation (GO:0060174)2.75104503
124gamma-aminobutyric acid transport (GO:0015812)2.75041951
125mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.74670116
126amino acid import (GO:0043090)2.74220299
127synaptic transmission (GO:0007268)2.73914158
128nerve growth factor signaling pathway (GO:0038180)2.68565961
129* establishment of mitochondrion localization (GO:0051654)2.67346466
130establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.67346466
131mitochondrion transport along microtubule (GO:0047497)2.67346466
132protein palmitoylation (GO:0018345)2.66198762
133peptidyl-tyrosine autophosphorylation (GO:0038083)2.65846668
134regulation of dopamine metabolic process (GO:0042053)2.64224906
135regulation of catecholamine metabolic process (GO:0042069)2.64224906
136regulation of neuronal synaptic plasticity (GO:0048168)2.63327592
137fatty-acyl-CoA biosynthetic process (GO:0046949)2.61814637
138positive regulation of synapse assembly (GO:0051965)2.61094984
139fatty-acyl-CoA metabolic process (GO:0035337)2.60626891
140dendrite morphogenesis (GO:0048813)2.59853816
141membrane tubulation (GO:0097320)2.58855578
142negative regulation of axon extension (GO:0030517)2.58725231
143amyloid precursor protein metabolic process (GO:0042982)2.58056441
144myelination in peripheral nervous system (GO:0022011)2.57502325
145peripheral nervous system axon ensheathment (GO:0032292)2.57502325
146positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.56202343
147glycine transport (GO:0015816)2.56017605
148chaperone-mediated protein transport (GO:0072321)2.54900066
149negative regulation of synaptic transmission (GO:0050805)2.54873577
150adult locomotory behavior (GO:0008344)2.54273406
151mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.54229177
152peptidyl-cysteine modification (GO:0018198)2.52792681
153detection of temperature stimulus (GO:0016048)2.52588346
154positive regulation of action potential (GO:0045760)2.51633826
155regulation of lipoprotein metabolic process (GO:0050746)2.51274056
156mechanosensory behavior (GO:0007638)2.50777856

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.19551090
2GBX2_23144817_ChIP-Seq_PC3_Human3.82528589
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.86889019
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.76302565
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.72828800
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.46508783
7TAF15_26573619_Chip-Seq_HEK293_Human2.40680213
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.38749825
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.38749825
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.34796020
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.31546149
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.30107575
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.29743344
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.26330467
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25807173
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.24291249
17SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.23943213
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.10324974
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.08653110
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.06712378
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.99862597
22RNF2_27304074_Chip-Seq_ESCs_Mouse1.95402038
23REST_21632747_ChIP-Seq_MESCs_Mouse1.95168267
24AR_21572438_ChIP-Seq_LNCaP_Human1.92822027
25* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.89642795
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75735312
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.75654323
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75087788
29VDR_22108803_ChIP-Seq_LS180_Human1.73250160
30* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69323059
31DROSHA_22980978_ChIP-Seq_HELA_Human1.67932088
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.65951466
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.65499164
34* RARB_27405468_Chip-Seq_BRAIN_Mouse1.65371427
35PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.62000002
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.61157627
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.60012206
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.57091417
39ER_23166858_ChIP-Seq_MCF-7_Human1.55382199
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.55001877
41P300_19829295_ChIP-Seq_ESCs_Human1.53842656
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52382522
43RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.52089085
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49020382
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.49002437
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.48225186
47RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.45887850
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.43702621
49SMAD4_21799915_ChIP-Seq_A2780_Human1.36955145
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36414633
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35496826
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.34795016
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32858400
54TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32447310
55CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31845805
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28388189
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27042974
58RNF2_27304074_Chip-Seq_NSC_Mouse1.26689764
59FUS_26573619_Chip-Seq_HEK293_Human1.25722320
60EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25162731
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.23355804
62IGF1R_20145208_ChIP-Seq_DFB_Human1.22417892
63STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.20391637
64STAT3_23295773_ChIP-Seq_U87_Human1.18574718
65CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.16363908
66OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.16326326
67GATA1_26923725_Chip-Seq_HPCs_Mouse1.14561571
68P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14350661
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12589787
70FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12221822
71KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08848480
72AR_19668381_ChIP-Seq_PC3_Human1.08336948
73* PRDM14_20953172_ChIP-Seq_ESCs_Human1.08087159
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07905531
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07095138
76* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07086670
77ERG_21242973_ChIP-ChIP_JURKAT_Human1.06926642
78CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06729775
79NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05739908
80MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05466220
81E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.05194923
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.04728572
83SOX2_21211035_ChIP-Seq_LN229_Gbm1.04688598
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.04629770
85RING1B_27294783_Chip-Seq_ESCs_Mouse1.04552721
86TCF4_23295773_ChIP-Seq_U87_Human1.04126528
87TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01880460
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00622240
89CMYC_18555785_Chip-Seq_ESCs_Mouse0.99058349
90SOX9_26525672_Chip-Seq_HEART_Mouse0.98389091
91MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97400299
92TAL1_26923725_Chip-Seq_HPCs_Mouse0.97063483
93* AR_25329375_ChIP-Seq_VCAP_Human0.96814126
94YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96740206
95NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96349995
96DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96253010
97RUNX2_22187159_ChIP-Seq_PCA_Human0.95903408
98AHR_22903824_ChIP-Seq_MCF-7_Human0.95564332
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94480255
100* RING1B_27294783_Chip-Seq_NPCs_Mouse0.93974914
101WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93844157
102ZNF274_21170338_ChIP-Seq_K562_Hela0.93081849
103LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93055498
104SMAD3_21741376_ChIP-Seq_ESCs_Human0.92403099
105NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91582235
106NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91582235
107JUN_21703547_ChIP-Seq_K562_Human0.91549801
108TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.91221944
109* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90983857
110TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.90326222
111SUZ12_18555785_Chip-Seq_ESCs_Mouse0.90289523
112IKZF1_21737484_ChIP-ChIP_HCT116_Human0.89979720
113WT1_19549856_ChIP-ChIP_CCG9911_Human0.89346482
114EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89159829
115KDM2B_26808549_Chip-Seq_REH_Human0.88977644
116LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88637946
117KLF5_20875108_ChIP-Seq_MESCs_Mouse0.87657657
118EP300_21415370_ChIP-Seq_HL-1_Mouse0.86589452
119IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.86106194
120CBP_20019798_ChIP-Seq_JUKART_Human0.86106194
121P300_18555785_Chip-Seq_ESCs_Mouse0.85628951
122TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85469110

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.73394739
2MP0004270_analgesia3.74812962
3MP0000920_abnormal_myelination3.74624854
4MP0004859_abnormal_synaptic_plasticity3.74398892
5MP0003635_abnormal_synaptic_transmissio2.85939103
6MP0002272_abnormal_nervous_system2.82558827
7MP0002064_seizures2.78030450
8MP0001529_abnormal_vocalization2.76075688
9MP0001486_abnormal_startle_reflex2.63776688
10MP0005423_abnormal_somatic_nervous2.59154149
11MP0003329_amyloid_beta_deposits2.56628238
12MP0009745_abnormal_behavioral_response2.55671462
13MP0009046_muscle_twitch2.50157133
14MP0002734_abnormal_mechanical_nocicepti2.48685480
15MP0001968_abnormal_touch/_nociception2.47861328
16MP0000778_abnormal_nervous_system2.41233164
17* MP0002063_abnormal_learning/memory/cond2.26823524
18MP0002736_abnormal_nociception_after2.24579437
19MP0002735_abnormal_chemical_nociception2.20690146
20MP0004142_abnormal_muscle_tone2.19654883
21MP0002572_abnormal_emotion/affect_behav2.18724820
22MP0004885_abnormal_endolymph2.13633229
23MP0004742_abnormal_vestibular_system2.10716671
24MP0003690_abnormal_glial_cell2.10083244
25MP0003950_abnormal_plasma_membrane2.07160230
26MP0005171_absent_coat_pigmentation1.96692366
27MP0001970_abnormal_pain_threshold1.94414340
28MP0003634_abnormal_glial_cell1.93306894
29MP0001440_abnormal_grooming_behavior1.88199171
30MP0002733_abnormal_thermal_nociception1.86350164
31MP0003136_yellow_coat_color1.84693152
32* MP0001905_abnormal_dopamine_level1.82430138
33MP0002067_abnormal_sensory_capabilities1.78498763
34MP0000955_abnormal_spinal_cord1.69385716
35MP0005394_taste/olfaction_phenotype1.61996486
36MP0005499_abnormal_olfactory_system1.61996486
37MP0002229_neurodegeneration1.59730436
38MP0006276_abnormal_autonomic_nervous1.57694541
39MP0008569_lethality_at_weaning1.57247888
40MP0002882_abnormal_neuron_morphology1.57191600
41MP0001485_abnormal_pinna_reflex1.56684231
42MP0005386_behavior/neurological_phenoty1.50417031
43MP0004924_abnormal_behavior1.50417031
44MP0005409_darkened_coat_color1.47805596
45MP0002184_abnormal_innervation1.47225782
46MP0003632_abnormal_nervous_system1.46371458
47* MP0002066_abnormal_motor_capabilities/c1.42655336
48MP0003631_nervous_system_phenotype1.41320396
49MP0005410_abnormal_fertilization1.38449957
50MP0003633_abnormal_nervous_system1.36845923
51MP0003121_genomic_imprinting1.36673666
52MP0002822_catalepsy1.36454992
53MP0002638_abnormal_pupillary_reflex1.32919108
54MP0001501_abnormal_sleep_pattern1.31451017
55MP0002557_abnormal_social/conspecific_i1.29990492
56MP0005646_abnormal_pituitary_gland1.28276090
57MP0005551_abnormal_eye_electrophysiolog1.28065046
58MP0002653_abnormal_ependyma_morphology1.26053173
59MP0000604_amyloidosis1.22869291
60MP0004043_abnormal_pH_regulation1.21977580
61MP0004811_abnormal_neuron_physiology1.20240825
62MP0001963_abnormal_hearing_physiology1.18511117
63MP0002752_abnormal_somatic_nervous1.16824365
64MP0006292_abnormal_olfactory_placode1.16402081
65MP0008789_abnormal_olfactory_epithelium1.16356207
66MP0008260_abnormal_autophagy1.16046359
67MP0004858_abnormal_nervous_system1.12273060
68MP0005645_abnormal_hypothalamus_physiol1.11011467
69MP0002102_abnormal_ear_morphology1.10743066
70MP0002152_abnormal_brain_morphology1.07512671
71MP0001984_abnormal_olfaction1.05137755
72MP0004134_abnormal_chest_morphology1.05079049
73MP0001986_abnormal_taste_sensitivity1.03109820
74MP0000049_abnormal_middle_ear1.01978325
75MP0008877_abnormal_DNA_methylation1.01427210
76MP0001299_abnormal_eye_distance/1.00697345
77MP0002909_abnormal_adrenal_gland1.00259929
78MP0001502_abnormal_circadian_rhythm0.98187354
79MP0000462_abnormal_digestive_system0.94731509
80MP0004133_heterotaxia0.93907550
81MP0001177_atelectasis0.85464333
82MP0002234_abnormal_pharynx_morphology0.85323266
83MP0004145_abnormal_muscle_electrophysio0.84795996
84MP0009780_abnormal_chondrocyte_physiolo0.84079052
85MP0000026_abnormal_inner_ear0.83544459
86MP0003938_abnormal_ear_development0.82418040
87MP0000631_abnormal_neuroendocrine_gland0.82134646
88MP0005623_abnormal_meninges_morphology0.81502497
89MP0005167_abnormal_blood-brain_barrier0.80275096
90MP0001188_hyperpigmentation0.80268338
91MP0000747_muscle_weakness0.80019345
92MP0000579_abnormal_nail_morphology0.78014034
93MP0005195_abnormal_posterior_eye0.76623928
94MP0003119_abnormal_digestive_system0.75275353
95MP0005187_abnormal_penis_morphology0.75274124
96MP0003122_maternal_imprinting0.74557426
97MP0000751_myopathy0.69166157
98MP0010678_abnormal_skin_adnexa0.68767143
99MP0005253_abnormal_eye_physiology0.68239842
100MP0000569_abnormal_digit_pigmentation0.67290008
101MP0003137_abnormal_impulse_conducting0.66125779
102MP0002069_abnormal_eating/drinking_beha0.65921550
103MP0006072_abnormal_retinal_apoptosis0.65878133
104MP0001664_abnormal_digestion0.64047281
105MP0003861_abnormal_nervous_system0.63144420
106MP0004381_abnormal_hair_follicle0.62694708
107MP0001943_abnormal_respiration0.62415261
108MP0005248_abnormal_Harderian_gland0.61788502
109MP0001346_abnormal_lacrimal_gland0.61781943
110MP0000566_synostosis0.60559729
111MP0002233_abnormal_nose_morphology0.60101604
112MP0004085_abnormal_heartbeat0.59891507
113MP0002751_abnormal_autonomic_nervous0.57840630
114MP0002082_postnatal_lethality0.57554389
115MP0010770_preweaning_lethality0.57554389
116MP0010769_abnormal_survival0.57397982
117MP0004147_increased_porphyrin_level0.56875730
118MP0002090_abnormal_vision0.54836004
119MP0003787_abnormal_imprinting0.54319762
120MP0000647_abnormal_sebaceous_gland0.51803515
121MP0003879_abnormal_hair_cell0.51288748
122MP0008874_decreased_physiological_sensi0.51271231
123MP0004036_abnormal_muscle_relaxation0.50737041

Predicted human phenotypes

RankGene SetZ-score
1Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.67739758
2Degeneration of the lateral corticospinal tracts (HP:0002314)5.67739758
3Neurofibrillary tangles (HP:0002185)5.47983688
4Abnormality of the corticospinal tract (HP:0002492)4.70554688
5Myokymia (HP:0002411)4.68695238
6Cerebral inclusion bodies (HP:0100314)4.15641174
7Focal motor seizures (HP:0011153)4.00435649
8Supranuclear gaze palsy (HP:0000605)3.94744183
9Termporal pattern (HP:0011008)3.84198882
10Insidious onset (HP:0003587)3.84198882
11Peripheral hypomyelination (HP:0007182)3.83242189
12Sensory axonal neuropathy (HP:0003390)3.60774660
13Polyphagia (HP:0002591)3.60436798
14Spastic gait (HP:0002064)3.53948311
15Ankle clonus (HP:0011448)3.40769620
16Parakeratosis (HP:0001036)3.31954995
17Increased serum pyruvate (HP:0003542)3.30498020
18Abnormality of glycolysis (HP:0004366)3.30498020
19Drooling (HP:0002307)3.25662662
20Pheochromocytoma (HP:0002666)3.23256280
21Onion bulb formation (HP:0003383)3.22570603
22Cerebral hypomyelination (HP:0006808)3.22422512
23Dysmetria (HP:0001310)3.19114537
24Epileptic encephalopathy (HP:0200134)3.09305749
25Scanning speech (HP:0002168)2.99255633
26Excessive salivation (HP:0003781)2.97131538
27Retinal dysplasia (HP:0007973)2.92435245
28Focal seizures (HP:0007359)2.88963348
29Leukodystrophy (HP:0002415)2.87606731
30Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.83688398
31Neuroendocrine neoplasm (HP:0100634)2.83061915
32Atonic seizures (HP:0010819)2.82345177
33Intention tremor (HP:0002080)2.81485532
34Action tremor (HP:0002345)2.79034458
35Epileptiform EEG discharges (HP:0011182)2.74448759
36Abnormality of the labia minora (HP:0012880)2.74321708
37Abnormal auditory evoked potentials (HP:0006958)2.69869354
38Hypsarrhythmia (HP:0002521)2.62235079
39EEG with generalized epileptiform discharges (HP:0011198)2.61302542
40Alacrima (HP:0000522)2.56358759
41Amyotrophic lateral sclerosis (HP:0007354)2.52748969
42Absent speech (HP:0001344)2.50858352
43Abnormality of the lower motor neuron (HP:0002366)2.49163985
44Lower limb muscle weakness (HP:0007340)2.47847637
45Abnormality of binocular vision (HP:0011514)2.47638859
46Diplopia (HP:0000651)2.47638859
47Akinesia (HP:0002304)2.46945481
48Mutism (HP:0002300)2.45571972
49Amblyopia (HP:0000646)2.44857059
50Segmental peripheral demyelination/remyelination (HP:0003481)2.44367668
51Spastic tetraplegia (HP:0002510)2.42509578
52Megalencephaly (HP:0001355)2.42232709
53Cortical dysplasia (HP:0002539)2.41884444
54Hyperventilation (HP:0002883)2.40172511
55Sleep apnea (HP:0010535)2.40108022
56Lissencephaly (HP:0001339)2.39923121
57Progressive cerebellar ataxia (HP:0002073)2.39099591
58Limb dystonia (HP:0002451)2.38795084
59Urinary urgency (HP:0000012)2.37114878
60Thickened helices (HP:0000391)2.37099609
61Failure to thrive in infancy (HP:0001531)2.36544099
62Broad-based gait (HP:0002136)2.33616449
63Congenital primary aphakia (HP:0007707)2.32840181
64Acute necrotizing encephalopathy (HP:0006965)2.30607711
65Nephrogenic diabetes insipidus (HP:0009806)2.30546100
66Hemiplegia (HP:0002301)2.28700714
67Split foot (HP:0001839)2.26254435
68Slow saccadic eye movements (HP:0000514)2.24602854
69Absent septum pellucidum (HP:0001331)2.20441541
70Hypoplasia of the corpus callosum (HP:0002079)2.19388058
71Anteriorly placed anus (HP:0001545)2.18273131
72Hypoplastic pelvis (HP:0008839)2.16651199
73Autoamputation (HP:0001218)2.15619740
74Vaginal atresia (HP:0000148)2.15255488
75Cerebral hemorrhage (HP:0001342)2.14912959
76Dialeptic seizures (HP:0011146)2.13823074
77CNS hypomyelination (HP:0003429)2.13081585
78Pachygyria (HP:0001302)2.12014679
79Hypoplasia of the brainstem (HP:0002365)2.11206288
80Aplasia/Hypoplasia of the brainstem (HP:0007362)2.11206288
81Torticollis (HP:0000473)2.09922944
82Genital tract atresia (HP:0001827)2.08977849
83Clumsiness (HP:0002312)2.08487729
84Progressive inability to walk (HP:0002505)2.05921500
85Aplasia involving bones of the upper limbs (HP:0009823)2.05790009
86Aplasia of the phalanges of the hand (HP:0009802)2.05790009
87Aplasia involving bones of the extremities (HP:0009825)2.05790009
88Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.05424638
89Gait imbalance (HP:0002141)2.03625177
90Truncal ataxia (HP:0002078)2.00760490
91Urinary bladder sphincter dysfunction (HP:0002839)1.99535968
92Status epilepticus (HP:0002133)1.99260597
93Foot dorsiflexor weakness (HP:0009027)1.99162157
94Poor speech (HP:0002465)1.98638532
95Decreased lacrimation (HP:0000633)1.98562330
96Poor suck (HP:0002033)1.98426554
97Dysdiadochokinesis (HP:0002075)1.97261017
98Morphological abnormality of the pyramidal tract (HP:0002062)1.97041439
99Decreased motor nerve conduction velocity (HP:0003431)1.95933898
100Abnormal mitochondria in muscle tissue (HP:0008316)1.95541558
101Abnormal eating behavior (HP:0100738)1.95210197
102Progressive macrocephaly (HP:0004481)1.94754009
103Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.93348661
104Hammertoe (HP:0001765)1.92333226
105Delusions (HP:0000746)1.92222524
106Neuronal loss in central nervous system (HP:0002529)1.91230453
107Absence seizures (HP:0002121)1.91052329
108Clonus (HP:0002169)1.90743703
109Congenital ichthyosiform erythroderma (HP:0007431)1.90606468
110Postural instability (HP:0002172)1.90181168
111Increased circulating renin level (HP:0000848)1.88521456
112Genetic anticipation (HP:0003743)1.87895826
113Anxiety (HP:0000739)1.86589415
114Gaze-evoked nystagmus (HP:0000640)1.86429431
115Oligodactyly (hands) (HP:0001180)1.85710221
116Abnormality of the septum pellucidum (HP:0007375)1.85569781
117Methylmalonic acidemia (HP:0002912)1.85017946
118Morphological abnormality of the inner ear (HP:0011390)1.84006927
119Specific learning disability (HP:0001328)1.83988659
120Generalized tonic-clonic seizures (HP:0002069)1.83493315
121Abnormality of the foot musculature (HP:0001436)1.82774562
122Febrile seizures (HP:0002373)1.82651371
123Paraplegia (HP:0010550)1.82063164
124Stridor (HP:0010307)1.81881279
125Bowel incontinence (HP:0002607)1.81669963
126Acute encephalopathy (HP:0006846)1.81524856
127Spastic tetraparesis (HP:0001285)1.81245030
128Esotropia (HP:0000565)1.81235414
129Synostosis involving the elbow (HP:0003938)1.80944611
130Humeroradial synostosis (HP:0003041)1.80944611
131Medial flaring of the eyebrow (HP:0010747)1.80652686
132Hypomagnesemia (HP:0002917)1.80007141
133Impaired vibration sensation in the lower limbs (HP:0002166)1.79851220
134Ulnar claw (HP:0001178)1.79276073
135Focal dystonia (HP:0004373)1.78958482
136Hemiparesis (HP:0001269)1.78172952
137Optic nerve hypoplasia (HP:0000609)1.77649217
138Visual hallucinations (HP:0002367)1.77314573
139Agitation (HP:0000713)1.77226939
140Distal sensory impairment (HP:0002936)1.76595957
141Poor eye contact (HP:0000817)1.73741179
142Hepatoblastoma (HP:0002884)1.73648486
143Depression (HP:0000716)1.72662141
144Inability to walk (HP:0002540)1.71323219
145Heterochromia iridis (HP:0001100)1.69078675
146Abnormal social behavior (HP:0012433)1.68113634
147Impaired social interactions (HP:0000735)1.68113634
148Abnormality of salivation (HP:0100755)1.67016024
149Spastic paraplegia (HP:0001258)1.66182766
150Muscular hypotonia of the trunk (HP:0008936)1.63425621

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.49299542
2OXSR13.53056833
3CASK2.92541250
4MARK12.67219617
5BCR2.53495477
6MAPKAPK52.33612714
7CDK192.26092359
8PKN12.23866023
9EPHA42.21879207
10EPHB12.08619545
11LIMK12.00711670
12UHMK11.99740764
13PRPF4B1.97292690
14NTRK31.90037660
15PNCK1.85059781
16WNK41.77108424
17NTRK11.69329390
18SIK21.67001739
19FGFR21.63946341
20CAMK2B1.61243615
21CSNK1G31.60572784
22PAK61.59946557
23SGK4941.58774141
24SGK2231.58774141
25WNK11.51236733
26TNIK1.51031793
27TRIM281.47778961
28PBK1.47307362
29CSNK1A1L1.46842555
30MAP3K91.45914094
31CSNK1G21.41202348
32DYRK21.40372697
33NTRK21.38749254
34MAP4K21.37099430
35ROCK21.32789881
36MAPK131.32150631
37MAP3K41.30259149
38MAP2K71.29674228
39MET1.27899466
40TESK21.27569120
41MINK11.26058552
42CDK51.22465036
43PHKG21.19079573
44PHKG11.19079573
45CAMK2D1.18457646
46CAMKK11.15499312
47FGR1.14372311
48NEK61.14081464
49CSNK1G11.13152945
50ARAF1.12759939
51CAMK2A1.11199419
52CDK141.08300023
53KSR21.03471216
54EPHA31.00511262
55CAMK2G1.00311892
56CDK180.99105177
57CDK150.98543763
58PLK20.97875748
59EPHB20.94340300
60GRK50.91497042
61DAPK20.90187221
62PAK30.87556681
63CDK11A0.86792858
64PRKCE0.85153110
65TYRO30.84103642
66MARK20.84022760
67BMPR1B0.81885882
68ERBB30.81751687
69MST40.78586296
70SGK20.76079256
71CAMK10.72693552
72CAMKK20.71605474
73MUSK0.71507216
74PRKD30.69218315
75CLK10.68776928
76DYRK1B0.65178948
77PRKCG0.64173856
78ICK0.63764868
79KSR10.59063376
80DYRK1A0.58229476
81BCKDK0.55281443
82PRKD10.54046155
83PTK2B0.53436977
84PDPK10.53135922
85PRKCQ0.52632859
86PRKCH0.52448365
87NME10.52080617
88CCNB10.51848214
89MAP2K40.50635799
90TESK10.50239513
91FYN0.49867658
92PRKG10.49181551
93CAMK40.48545572
94ERBB40.48393096
95FES0.47994530
96MAP3K20.47850455
97DAPK10.47618255
98STK110.47297026
99GRK70.47019353
100PINK10.45973734
101BMPR20.45941600
102ADRBK20.45808566
103PRKACB0.44953178
104CSNK1A10.43840246
105WNK30.41029989
106RPS6KA30.40795312
107ERBB20.40237813
108PRKACA0.39209171
109DAPK30.38441281
110CSNK1E0.35943860
111CSNK1D0.34785137
112SGK10.34612054
113MAP3K130.34558271
114MAP3K120.34157718
115MAPK150.33099557
116RPS6KA40.32895087
117PRKCZ0.32417379
118LATS20.32413351
119ADRBK10.31159170
120LMTK20.30612047
121MAPK100.29927178
122MAP3K60.29756735
123SRPK10.29481254
124CAMK1G0.29361605
125ROCK10.29064172
126DYRK30.29001658
127PRKCA0.28756359
128SGK30.28312614
129RAF10.28245938
130STK380.27143769

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.35106182
2Steroid biosynthesis_Homo sapiens_hsa001003.37465277
3Fatty acid elongation_Homo sapiens_hsa000623.21111038
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.07885609
5Nicotine addiction_Homo sapiens_hsa050332.41534925
6Oxidative phosphorylation_Homo sapiens_hsa001902.36534391
7Synaptic vesicle cycle_Homo sapiens_hsa047212.19461021
8Ether lipid metabolism_Homo sapiens_hsa005652.18607285
9GABAergic synapse_Homo sapiens_hsa047272.17927841
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.05274150
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.04541274
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.03805465
13Glutamatergic synapse_Homo sapiens_hsa047242.01543950
14Collecting duct acid secretion_Homo sapiens_hsa049661.93974476
15Morphine addiction_Homo sapiens_hsa050321.88401359
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.86939710
17Parkinsons disease_Homo sapiens_hsa050121.78613336
18Axon guidance_Homo sapiens_hsa043601.74344370
19Circadian entrainment_Homo sapiens_hsa047131.73857197
20Serotonergic synapse_Homo sapiens_hsa047261.72350449
21Alzheimers disease_Homo sapiens_hsa050101.65078083
22Long-term depression_Homo sapiens_hsa047301.52913825
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.47339690
24Dopaminergic synapse_Homo sapiens_hsa047281.46566492
25Vitamin B6 metabolism_Homo sapiens_hsa007501.44630864
26Vibrio cholerae infection_Homo sapiens_hsa051101.38381078
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33673686
28Olfactory transduction_Homo sapiens_hsa047401.33523276
29Salivary secretion_Homo sapiens_hsa049701.32545779
30Taste transduction_Homo sapiens_hsa047421.30268522
31Cocaine addiction_Homo sapiens_hsa050301.27984526
32Amphetamine addiction_Homo sapiens_hsa050311.27962698
33Long-term potentiation_Homo sapiens_hsa047201.27235532
34Butanoate metabolism_Homo sapiens_hsa006501.24341940
35Cardiac muscle contraction_Homo sapiens_hsa042601.20201203
36Cholinergic synapse_Homo sapiens_hsa047251.19329909
37Sulfur metabolism_Homo sapiens_hsa009201.16261573
38Gastric acid secretion_Homo sapiens_hsa049711.12941386
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11867305
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.11520159
41Sphingolipid metabolism_Homo sapiens_hsa006001.06873281
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.03481795
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.02440616
44Huntingtons disease_Homo sapiens_hsa050161.01773980
45Phototransduction_Homo sapiens_hsa047440.98677067
46Renin secretion_Homo sapiens_hsa049240.98157221
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.97230135
48Insulin secretion_Homo sapiens_hsa049110.96640772
49Gap junction_Homo sapiens_hsa045400.95729720
50beta-Alanine metabolism_Homo sapiens_hsa004100.92115251
51Protein export_Homo sapiens_hsa030600.91542075
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.90015168
53Renal cell carcinoma_Homo sapiens_hsa052110.86638289
54Linoleic acid metabolism_Homo sapiens_hsa005910.84537472
55Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.82658823
56Oocyte meiosis_Homo sapiens_hsa041140.79915289
57Calcium signaling pathway_Homo sapiens_hsa040200.79807403
58Sphingolipid signaling pathway_Homo sapiens_hsa040710.79140917
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.76216008
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76030996
61ErbB signaling pathway_Homo sapiens_hsa040120.75869203
62Histidine metabolism_Homo sapiens_hsa003400.74470210
63Nitrogen metabolism_Homo sapiens_hsa009100.74157200
64Hippo signaling pathway_Homo sapiens_hsa043900.74047454
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73842275
66Rheumatoid arthritis_Homo sapiens_hsa053230.73822896
67Oxytocin signaling pathway_Homo sapiens_hsa049210.73333559
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72881336
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69945464
70Ras signaling pathway_Homo sapiens_hsa040140.69589610
71cAMP signaling pathway_Homo sapiens_hsa040240.65931137
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65313679
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.64621678
74Phagosome_Homo sapiens_hsa041450.62200343
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61124297
76Tight junction_Homo sapiens_hsa045300.60723192
77Endocytosis_Homo sapiens_hsa041440.60615125
78Pancreatic secretion_Homo sapiens_hsa049720.60501222
79Melanogenesis_Homo sapiens_hsa049160.60210152
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59955513
81GnRH signaling pathway_Homo sapiens_hsa049120.59876380
82Circadian rhythm_Homo sapiens_hsa047100.58734914
83Regulation of autophagy_Homo sapiens_hsa041400.58682519
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57980882
85Dorso-ventral axis formation_Homo sapiens_hsa043200.56569272
86Arginine and proline metabolism_Homo sapiens_hsa003300.54905232
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54311362
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.52874774
89Ovarian steroidogenesis_Homo sapiens_hsa049130.52496186
90Bile secretion_Homo sapiens_hsa049760.52441088
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52094107
92Type II diabetes mellitus_Homo sapiens_hsa049300.51770809
93Hedgehog signaling pathway_Homo sapiens_hsa043400.49871862
94Mineral absorption_Homo sapiens_hsa049780.49222554
952-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48814546
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47870809
97Thyroid hormone synthesis_Homo sapiens_hsa049180.47006163
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46420825
99Alcoholism_Homo sapiens_hsa050340.46325705
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46113431
101Wnt signaling pathway_Homo sapiens_hsa043100.45816271
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44469213
103Dilated cardiomyopathy_Homo sapiens_hsa054140.42742793
104Choline metabolism in cancer_Homo sapiens_hsa052310.41477383
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41343964
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41177481
107MAPK signaling pathway_Homo sapiens_hsa040100.38554813
108Propanoate metabolism_Homo sapiens_hsa006400.38224955
109Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37734152
110Glioma_Homo sapiens_hsa052140.37105429
111Estrogen signaling pathway_Homo sapiens_hsa049150.37018733
112Pyruvate metabolism_Homo sapiens_hsa006200.35768071
113AMPK signaling pathway_Homo sapiens_hsa041520.35012816
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.33630087
115Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.33432299
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33064349
117Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.32792649
118Arginine biosynthesis_Homo sapiens_hsa002200.32432576
119Fatty acid metabolism_Homo sapiens_hsa012120.30112942
120Prion diseases_Homo sapiens_hsa050200.29515211
121Fatty acid biosynthesis_Homo sapiens_hsa000610.28471651
122Rap1 signaling pathway_Homo sapiens_hsa040150.27678152

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