FEZF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcriptional repressor that belongs to the zinc finger double domain protein family. The encoded protein is thought to play a role in the embryonic migration of gonadotropin-releasing hormone neurons into the brain. Mutations in this gene are associated with hypogonadotropic hypogonadism-22 with anosmia. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H4 deacetylation (GO:0070933)9.46210595
2negative regulation of transcription regulatory region DNA binding (GO:2000678)8.95915959
3positive regulation of oligodendrocyte differentiation (GO:0048714)8.74206329
4central nervous system myelination (GO:0022010)7.58991101
5axon ensheathment in central nervous system (GO:0032291)7.58991101
6regulation of sarcomere organization (GO:0060297)7.34297201
7cerebral cortex neuron differentiation (GO:0021895)7.15274754
8* olfactory bulb development (GO:0021772)7.05689215
9eyelid development in camera-type eye (GO:0061029)6.83937313
10negative regulation of astrocyte differentiation (GO:0048712)6.77408751
11regulation of oligodendrocyte differentiation (GO:0048713)6.42555268
12sensory perception of smell (GO:0007608)6.34954840
13sequestering of actin monomers (GO:0042989)5.92712978
14pyrimidine nucleobase catabolic process (GO:0006208)5.84205177
15negative regulation of heart growth (GO:0061117)5.82390946
16negative regulation of cardiac muscle tissue growth (GO:0055022)5.82390946
17negative regulation of oligodendrocyte differentiation (GO:0048715)5.82277439
18paraxial mesoderm development (GO:0048339)5.45284732
19neuroblast proliferation (GO:0007405)5.38678141
20positive regulation of receptor biosynthetic process (GO:0010870)5.36032839
21regulation of MHC class II biosynthetic process (GO:0045346)5.34629524
22hippocampus development (GO:0021766)5.28886123
23dosage compensation (GO:0007549)5.18682041
24axon extension (GO:0048675)5.18244541
25response to pheromone (GO:0019236)5.09275223
26centriole replication (GO:0007099)4.98735853
27regulation of cilium movement (GO:0003352)4.94866212
28negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 4.90902726
29snRNA transcription (GO:0009301)4.86489286
30acrosome reaction (GO:0007340)4.84273421
31histone deacetylation (GO:0016575)4.77994048
32regulation of transcription regulatory region DNA binding (GO:2000677)4.73419471
33protein insertion into membrane (GO:0051205)4.52840610
34nucleobase catabolic process (GO:0046113)4.49251261
35protein deacetylation (GO:0006476)4.45826438
36neuron projection extension (GO:1990138)4.37769638
37protein polyglutamylation (GO:0018095)4.37332383
38natural killer cell mediated cytotoxicity (GO:0042267)4.35344128
39natural killer cell mediated immunity (GO:0002228)4.35344128
40behavioral response to cocaine (GO:0048148)4.27898408
41regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 4.24313696
42lactate metabolic process (GO:0006089)4.22953331
43pre-miRNA processing (GO:0031054)4.22149292
44adipose tissue development (GO:0060612)4.17765632
45keratinocyte development (GO:0003334)4.17740349
46ovulation cycle (GO:0042698)4.12868389
47centriole assembly (GO:0098534)4.09202523
48regulation of double-strand break repair via homologous recombination (GO:0010569)4.05626708
49cell proliferation in forebrain (GO:0021846)4.05320599
50behavioral response to nicotine (GO:0035095)3.98360421
51protein deacylation (GO:0035601)3.92183851
52G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.90288934
53somite development (GO:0061053)3.86693218
54intraciliary transport (GO:0042073)3.86611770
55ectodermal placode formation (GO:0060788)3.86331033
56sensory perception of chemical stimulus (GO:0007606)3.74845925
57regulation of female receptivity (GO:0045924)3.72607763
58macromolecule deacylation (GO:0098732)3.72218215
59microtubule severing (GO:0051013)3.70266868
60negative regulation of glial cell differentiation (GO:0045686)3.67436951
61retinal ganglion cell axon guidance (GO:0031290)3.62776871
62regulation of glial cell differentiation (GO:0045685)3.57111141
63regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.56781758
64ganglion development (GO:0061548)3.56112946
65negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)3.56110007
66modulation by virus of host process (GO:0019054)3.54659806
67neuronal stem cell maintenance (GO:0097150)3.53363028
68mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.50192699
69epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.49820576
70axonemal dynein complex assembly (GO:0070286)3.49639280
71appendage development (GO:0048736)3.47028268
72limb development (GO:0060173)3.47028268
73positive regulation of mitochondrial fission (GO:0090141)3.43018334
74nonmotile primary cilium assembly (GO:0035058)3.42852440
75left/right axis specification (GO:0070986)3.42641946
76cerebral cortex development (GO:0021987)3.41544557
77protein localization to cilium (GO:0061512)3.41243689
78regulation of astrocyte differentiation (GO:0048710)3.39429663
79positive regulation of glial cell differentiation (GO:0045687)3.38261724
80forebrain neuron differentiation (GO:0021879)3.38072860
81phosphorelay signal transduction system (GO:0000160)3.35745953
82developmental cell growth (GO:0048588)3.32992160
83female mating behavior (GO:0060180)3.32872440
84central nervous system projection neuron axonogenesis (GO:0021952)3.32501035
85histone H3 deacetylation (GO:0070932)3.30925923
86regulation of development, heterochronic (GO:0040034)3.28711467
87positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.28613385
88mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.28613385
89negative regulation of cardiac muscle tissue development (GO:0055026)3.27835859
90regulation of NFAT protein import into nucleus (GO:0051532)3.27192923
91regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.24354006
92epithelial cilium movement (GO:0003351)3.23559211
93negative regulation of gliogenesis (GO:0014014)3.21538078
94neuron fate determination (GO:0048664)3.20505985
95dendrite development (GO:0016358)3.16072430
96neuron cell-cell adhesion (GO:0007158)3.15487395
97regulation of collateral sprouting (GO:0048670)3.15015552
98positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.14654034
99calcium ion-dependent exocytosis (GO:0017156)3.14596175
100chromatin remodeling at centromere (GO:0031055)3.12237441
101microtubule depolymerization (GO:0007019)3.12002278
102axon extension involved in axon guidance (GO:0048846)3.11875851
103neuron projection extension involved in neuron projection guidance (GO:1902284)3.11875851
104calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.11867971
105cilium movement (GO:0003341)3.11855318
106establishment of epithelial cell polarity (GO:0090162)3.09612201
107ectoderm development (GO:0007398)3.08254638
108calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.07353457
109regulation of protein deacetylation (GO:0090311)3.06620096
110heterochromatin organization (GO:0070828)3.05343307
111endocrine hormone secretion (GO:0060986)3.04061721
112regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)3.02956857
113outer ear morphogenesis (GO:0042473)3.01298230
114negative regulation of DNA binding (GO:0043392)3.00060943
115regulation of microtubule-based movement (GO:0060632)2.98292870
116mating behavior (GO:0007617)2.96256921
117presynaptic membrane assembly (GO:0097105)2.95332481
118presynaptic membrane organization (GO:0097090)2.93920007
119male meiosis (GO:0007140)2.92292608
120spinal cord association neuron differentiation (GO:0021527)2.90847311
121negative regulation of organ growth (GO:0046621)2.89407227
122regulation of timing of cell differentiation (GO:0048505)2.89403652
123neuron recognition (GO:0008038)2.85478729
124axoneme assembly (GO:0035082)2.84832663
125regulation of heart rate by cardiac conduction (GO:0086091)2.84435441
126microtubule bundle formation (GO:0001578)2.83216903
127regulation of gliogenesis (GO:0014013)2.82482479
128regulation of posttranscriptional gene silencing (GO:0060147)2.82423673
129regulation of gene silencing by miRNA (GO:0060964)2.82423673
130regulation of gene silencing by RNA (GO:0060966)2.82423673
131positive regulation of DNA-templated transcription, elongation (GO:0032786)2.82305736
132axonal fasciculation (GO:0007413)2.82081958
133positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.80727440
134spinal cord development (GO:0021510)2.80726551
135regulation of mRNA splicing, via spliceosome (GO:0048024)2.79347747
136cilium assembly (GO:0042384)2.79136779
137cell migration in hindbrain (GO:0021535)2.78540285
138pituitary gland development (GO:0021983)2.77758724
139cilium organization (GO:0044782)2.76251217
140CENP-A containing nucleosome assembly (GO:0034080)2.74505889
141negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902230)2.74434232
142negative regulation of microtubule polymerization (GO:0031115)2.74382899
143short-term memory (GO:0007614)2.73090346
144ephrin receptor signaling pathway (GO:0048013)2.70253052
145protein localization to synapse (GO:0035418)2.67889889
146substrate-independent telencephalic tangential migration (GO:0021826)2.67881031
147substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.67881031
148convergent extension (GO:0060026)2.66957573
149dendritic spine morphogenesis (GO:0060997)2.65928851
150ncRNA catabolic process (GO:0034661)2.63956985
151inner ear receptor cell development (GO:0060119)2.63785366
152tongue development (GO:0043586)2.63468655
153cilium morphogenesis (GO:0060271)2.62695916
154establishment of integrated proviral latency (GO:0075713)2.61093087
155postsynaptic membrane organization (GO:0001941)2.60999197
156head development (GO:0060322)2.59307836
157dorsal/ventral axis specification (GO:0009950)2.58484037
158establishment of protein localization to mitochondrial membrane (GO:0090151)2.55763713
159central nervous system neuron axonogenesis (GO:0021955)2.55228868
160ATP-dependent chromatin remodeling (GO:0043044)2.51726183
161regulation of growth hormone secretion (GO:0060123)2.51071662
162DNA ligation (GO:0006266)2.49624785
163otic vesicle formation (GO:0030916)2.47752049
164neural tube formation (GO:0001841)2.47197558
165cell fate commitment involved in formation of primary germ layer (GO:0060795)2.46962120
166DNA integration (GO:0015074)2.44865720
167DNA replication-independent nucleosome organization (GO:0034724)2.44079803
168DNA replication-independent nucleosome assembly (GO:0006336)2.44079803
169protein-DNA complex disassembly (GO:0032986)2.43705595
170nucleosome disassembly (GO:0006337)2.43705595
171lung-associated mesenchyme development (GO:0060484)2.43164598
172DNA damage response, detection of DNA damage (GO:0042769)2.41864550
173ribosomal small subunit assembly (GO:0000028)2.41839706
174mesenchymal to epithelial transition (GO:0060231)2.41570010
175establishment of mitochondrion localization (GO:0051654)2.40741739
176dorsal/ventral pattern formation (GO:0009953)2.39700396
177positive regulation of neuroblast proliferation (GO:0002052)2.39274283
178smoothened signaling pathway (GO:0007224)2.38331975
179planar cell polarity pathway involved in neural tube closure (GO:0090179)2.37524195
180kinetochore assembly (GO:0051382)2.36907939
181developmental induction (GO:0031128)2.36868625
182forebrain morphogenesis (GO:0048853)2.34277265
183regulation of cell fate specification (GO:0042659)2.33610312
184transmission of nerve impulse (GO:0019226)2.33302494
185regulation of chromatin binding (GO:0035561)11.9905717

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse7.92778278
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.07980355
3IRF1_19129219_ChIP-ChIP_H3396_Human2.87490541
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.81440553
5IGF1R_20145208_ChIP-Seq_DFB_Human2.69123025
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.59186454
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.59186454
8IKZF1_21737484_ChIP-ChIP_HCT116_Human2.53184808
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.48237410
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.41431401
11* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.40287140
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.39980262
13ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.18640302
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.16543327
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.15227460
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.11586306
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.10738545
18RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.06190534
19PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.04001930
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.03880227
21* TAF15_26573619_Chip-Seq_HEK293_Human2.00858762
22* RING1B_27294783_Chip-Seq_ESCs_Mouse2.00462952
23EZH2_22144423_ChIP-Seq_EOC_Human10.9845465
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.96820298
25* CBX2_27304074_Chip-Seq_ESCs_Mouse1.93277200
26* RNF2_27304074_Chip-Seq_ESCs_Mouse1.90758276
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.90107021
28FUS_26573619_Chip-Seq_HEK293_Human1.85400300
29* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.85234661
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.80667064
31MYC_18940864_ChIP-ChIP_HL60_Human1.79811780
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.77591492
33EWS_26573619_Chip-Seq_HEK293_Human1.76955293
34* RING1B_27294783_Chip-Seq_NPCs_Mouse1.76303772
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.76249598
36AHR_22903824_ChIP-Seq_MCF-7_Human1.75326392
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.73223490
38* EZH2_27294783_Chip-Seq_ESCs_Mouse1.73087662
39* EZH2_27304074_Chip-Seq_ESCs_Mouse1.71431362
40SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.67087065
41E2F4_17652178_ChIP-ChIP_JURKAT_Human1.65096090
42NANOG_16153702_ChIP-ChIP_HESCs_Human1.62214066
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.60814036
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.59381991
45* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.58572889
46BP1_19119308_ChIP-ChIP_Hs578T_Human1.57173320
47SOX2_18555785_ChIP-Seq_MESCs_Mouse1.56681285
48FOXM1_23109430_ChIP-Seq_U2OS_Human1.51373406
49MTF2_20144788_ChIP-Seq_MESCs_Mouse1.47005265
50* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.45680202
51DROSHA_22980978_ChIP-Seq_HELA_Human1.44686001
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41523502
53NFIB_24661679_ChIP-Seq_LUNG_Mouse1.40265002
54MYC_18555785_ChIP-Seq_MESCs_Mouse1.40019793
55HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.39482908
56CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.38276573
57EST1_17652178_ChIP-ChIP_JURKAT_Human1.38258129
58E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.37154791
59TP63_19390658_ChIP-ChIP_HaCaT_Human1.36814972
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.36252673
61REST_21632747_ChIP-Seq_MESCs_Mouse1.34113880
62* RNF2_27304074_Chip-Seq_NSC_Mouse1.32673125
63GBX2_23144817_ChIP-Seq_PC3_Human1.32099137
64GABP_17652178_ChIP-ChIP_JURKAT_Human1.31171831
65WT1_19549856_ChIP-ChIP_CCG9911_Human1.29656847
66TP53_20018659_ChIP-ChIP_R1E_Mouse1.29020336
67RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.28701193
68EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28025490
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27096100
70KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.26762091
71ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26474872
72NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.26461610
73SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.24961353
74ERG_21242973_ChIP-ChIP_JURKAT_Human1.24203328
75RARB_27405468_Chip-Seq_BRAIN_Mouse1.24029837
76VDR_22108803_ChIP-Seq_LS180_Human1.23323734
77GATA1_26923725_Chip-Seq_HPCs_Mouse1.22584403
78FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.21542494
79ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20171827
80FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.19791325
81TDRD3_21172665_ChIP-Seq_MCF-7_Human1.18305920
82ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18208558
83EGR1_19374776_ChIP-ChIP_THP-1_Human1.17942400
84ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.17713674
85CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15793130
86RUNX1_26923725_Chip-Seq_HPCs_Mouse1.15719617
87KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.15541777
88YY1_21170310_ChIP-Seq_MESCs_Mouse1.15518035
89* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.15425088
90TTF2_22483619_ChIP-Seq_HELA_Human1.14648828
91SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.13500890
92YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13239214
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13057322
94KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.12338881
95POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.11833542
96ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10496791
97ARNT_22903824_ChIP-Seq_MCF-7_Human1.10252286
98MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.08547332
99WDR5_24793694_ChIP-Seq_LNCAP_Human1.08342584
100CREB1_15753290_ChIP-ChIP_HEK293T_Human1.07323074
101ELK1_19687146_ChIP-ChIP_HELA_Human1.07068846
102POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06426190
103XRN2_22483619_ChIP-Seq_HELA_Human1.06186452
104TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05276149
105PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05091116
106FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.05057263
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03703296
108PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01770780
109TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99644322
110SOX9_26525672_Chip-Seq_HEART_Mouse0.99572118
111ISL1_27105846_Chip-Seq_CPCs_Mouse0.98734799
112NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.98719152
113DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98269968
114REST_18959480_ChIP-ChIP_MESCs_Mouse0.97222260
115DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96996285
116ZNF274_21170338_ChIP-Seq_K562_Hela0.95447162
117TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95089953
118OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.94263023
119TP53_18474530_ChIP-ChIP_U2OS_Human0.94154718
120ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94034531
121ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93546653
122EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92821481
123* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.92754081
124TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.92313866
125CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.91536260
126TBX3_20139965_ChIP-Seq_ESCs_Mouse0.91041764
127TBX3_20139965_ChIP-Seq_MESCs_Mouse0.89361523
128KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88848354
129PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88723471
130BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.88428027
131MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.88057699
132TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87905508
133E2F1_18555785_ChIP-Seq_MESCs_Mouse0.87510477
134FOXH1_21741376_ChIP-Seq_EPCs_Human0.86492822
135SOX2_16153702_ChIP-ChIP_HESCs_Human0.85065958
136POU5F1_16153702_ChIP-ChIP_HESCs_Human0.83664504
137CTBP2_25329375_ChIP-Seq_LNCAP_Human0.82723840
138TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81505758
139POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.81505758
140YAP1_20516196_ChIP-Seq_MESCs_Mouse0.78890187
141WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.78213550
142RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.78100076
143MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.77683779
144PIAS1_25552417_ChIP-Seq_VCAP_Human0.77664571
145SMAD4_21741376_ChIP-Seq_EPCs_Human0.77567390
146TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76407728
147OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.73674064
148KDM2B_26808549_Chip-Seq_K562_Human0.73202885
149NR3C1_21868756_ChIP-Seq_MCF10A_Human0.69408117
150POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.69280105
151SMAD3_21741376_ChIP-Seq_EPCs_Human0.68475298
152* P300_19829295_ChIP-Seq_ESCs_Human0.68207753
153GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.67787457
154MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.67579082

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008789_abnormal_olfactory_epithelium8.61077288
2MP0005394_taste/olfaction_phenotype7.56541485
3MP0005499_abnormal_olfactory_system7.56541485
4MP0005645_abnormal_hypothalamus_physiol5.34784328
5MP0001984_abnormal_olfaction3.80244018
6MP0002653_abnormal_ependyma_morphology3.73418340
7MP0003787_abnormal_imprinting3.50787314
8MP0003122_maternal_imprinting3.41862387
9MP0010030_abnormal_orbit_morphology2.94332124
10MP0001293_anophthalmia2.56473852
11MP0003136_yellow_coat_color2.45566628
12MP0000778_abnormal_nervous_system2.34382819
13MP0002160_abnormal_reproductive_system2.30670570
14MP0002184_abnormal_innervation2.25328561
15MP0002233_abnormal_nose_morphology2.19208198
16MP0003890_abnormal_embryonic-extraembry2.14300749
17MP0000427_abnormal_hair_cycle2.09369135
18MP0001542_abnormal_bone_strength1.99568669
19MP0003878_abnormal_ear_physiology1.98883599
20MP0005377_hearing/vestibular/ear_phenot1.98883599
21MP0001485_abnormal_pinna_reflex1.86508414
22MP0001529_abnormal_vocalization1.81062357
23MP0008877_abnormal_DNA_methylation1.72764970
24MP0002697_abnormal_eye_size1.62780264
25MP0003938_abnormal_ear_development1.56990110
26MP0005623_abnormal_meninges_morphology1.56898825
27MP0003123_paternal_imprinting1.55507429
28MP0000003_abnormal_adipose_tissue1.52744386
29MP0002938_white_spotting1.52520352
30MP0005187_abnormal_penis_morphology1.50364354
31MP0002638_abnormal_pupillary_reflex1.48109523
32MP0002234_abnormal_pharynx_morphology1.47003610
33MP0002102_abnormal_ear_morphology1.44615122
34MP0001299_abnormal_eye_distance/1.43988923
35MP0005253_abnormal_eye_physiology1.42812191
36MP0006276_abnormal_autonomic_nervous1.42303957
37MP0004885_abnormal_endolymph1.40678316
38MP0004859_abnormal_synaptic_plasticity1.40072423
39MP0009250_abnormal_appendicular_skeleto1.36902008
40MP0004270_analgesia1.33126356
41MP0000566_synostosis1.32909796
42MP0002557_abnormal_social/conspecific_i1.28358409
43MP0001286_abnormal_eye_development1.26438697
44MP0000372_irregular_coat_pigmentation1.25629566
45* MP0002882_abnormal_neuron_morphology1.24927478
46MP0003755_abnormal_palate_morphology1.23091382
47MP0002249_abnormal_larynx_morphology1.22411764
48* MP0002752_abnormal_somatic_nervous1.20527072
49MP0003121_genomic_imprinting1.19903406
50MP0008932_abnormal_embryonic_tissue1.19677398
51MP0003567_abnormal_fetal_cardiomyocyte1.17484079
52MP0000428_abnormal_craniofacial_morphol1.16224985
53MP0006072_abnormal_retinal_apoptosis1.15160622
54MP0009053_abnormal_anal_canal1.13773458
55MP0000049_abnormal_middle_ear1.12318747
56MP0003635_abnormal_synaptic_transmissio1.09971878
57* MP0002152_abnormal_brain_morphology1.09631329
58MP0001486_abnormal_startle_reflex1.09133462
59* MP0003861_abnormal_nervous_system1.05051348
60MP0002111_abnormal_tail_morphology1.03998320
61MP0004133_heterotaxia1.03562196
62MP0000516_abnormal_urinary_system1.02909246
63MP0005367_renal/urinary_system_phenotyp1.02909246
64MP0005389_reproductive_system_phenotype1.01726544
65MP0003942_abnormal_urinary_system0.99241106
66MP0002272_abnormal_nervous_system0.98761916
67MP0002092_abnormal_eye_morphology0.97250695
68MP0004215_abnormal_myocardial_fiber0.97147994
69MP0003315_abnormal_perineum_morphology0.96535685
70MP0002063_abnormal_learning/memory/cond0.94791587
71MP0002085_abnormal_embryonic_tissue0.93880271
72MP0005423_abnormal_somatic_nervous0.92798570
73MP0002254_reproductive_system_inflammat0.90093063
74MP0001188_hyperpigmentation0.90076454
75MP0002084_abnormal_developmental_patter0.89649369
76MP0004957_abnormal_blastocyst_morpholog0.88859504
77MP0003221_abnormal_cardiomyocyte_apopto0.85938730
78MP0002116_abnormal_craniofacial_bone0.84933677
79MP0004197_abnormal_fetal_growth/weight/0.83727179
80MP0003763_abnormal_thymus_physiology0.83367804
81MP0003011_delayed_dark_adaptation0.83299093
82MP0009379_abnormal_foot_pigmentation0.83042682
83MP0000955_abnormal_spinal_cord0.81574550
84MP0000537_abnormal_urethra_morphology0.81362113
85MP0002896_abnormal_bone_mineralization0.80870137
86MP0004742_abnormal_vestibular_system0.78077304
87MP0001502_abnormal_circadian_rhythm0.77913866
88MP0004142_abnormal_muscle_tone0.77699642
89* MP0002081_perinatal_lethality0.76805815
90MP0002877_abnormal_melanocyte_morpholog0.76757437
91MP0001346_abnormal_lacrimal_gland0.75604211
92MP0003634_abnormal_glial_cell0.73139734
93MP0005195_abnormal_posterior_eye0.70205260
94MP0003880_abnormal_central_pattern0.70171663
95MP0002210_abnormal_sex_determination0.69944542
96MP0003698_abnormal_male_reproductive0.69855558
97MP0005551_abnormal_eye_electrophysiolog0.69372536
98MP0010386_abnormal_urinary_bladder0.68711214
99MP0002282_abnormal_trachea_morphology0.67328180
100MP0002734_abnormal_mechanical_nocicepti0.67279670
101MP0004134_abnormal_chest_morphology0.66762644
102MP0008995_early_reproductive_senescence0.66625088
103MP0005391_vision/eye_phenotype0.66435474
104MP0006054_spinal_hemorrhage0.65666809
105MP0000026_abnormal_inner_ear0.64994830
106MP0001145_abnormal_male_reproductive0.64622953
107MP0000432_abnormal_head_morphology0.64547323
108MP0000653_abnormal_sex_gland0.64023352
109MP0002127_abnormal_cardiovascular_syste0.63633239
110MP0003137_abnormal_impulse_conducting0.62289636
111MP0009672_abnormal_birth_weight0.62089205
112MP0000490_abnormal_crypts_of0.61604744
113MP0001963_abnormal_hearing_physiology0.61558660
114MP0010234_abnormal_vibrissa_follicle0.57650941
115MP0002932_abnormal_joint_morphology0.55561491
116MP0000647_abnormal_sebaceous_gland0.55153939
117MP0005360_urolithiasis0.55129562
118MP0002751_abnormal_autonomic_nervous0.53293477
119MP0009745_abnormal_behavioral_response0.52870818
120MP0009115_abnormal_fat_cell0.52183022
121* MP0004811_abnormal_neuron_physiology0.51874536
122MP0005174_abnormal_tail_pigmentation0.51734679
123MP0009703_decreased_birth_body0.51514818
124MP0000631_abnormal_neuroendocrine_gland0.50651632
125MP0002067_abnormal_sensory_capabilities0.50521248
126MP0000751_myopathy0.50482497
127MP0001849_ear_inflammation0.49898220
128MP0002572_abnormal_emotion/affect_behav0.49720107
129MP0003693_abnormal_embryo_hatching0.49495726
130MP0001119_abnormal_female_reproductive0.49259472
131MP0005248_abnormal_Harderian_gland0.48858731
132MP0005375_adipose_tissue_phenotype0.48800377
133MP0002064_seizures0.48323036
134MP0003937_abnormal_limbs/digits/tail_de0.46653373
135MP0005084_abnormal_gallbladder_morpholo0.45866560
136MP0001440_abnormal_grooming_behavior0.45771210
137MP0003119_abnormal_digestive_system0.45712170
138MP0003638_abnormal_response/metabolism_0.42180720
139MP0001340_abnormal_eyelid_morphology0.41745466
140MP0006292_abnormal_olfactory_placode0.40986893
141MP0001270_distended_abdomen0.40867149
142MP0004085_abnormal_heartbeat0.40534927

Predicted human phenotypes

RankGene SetZ-score
1Pelvic girdle muscle weakness (HP:0003749)6.49259121
2Abnormality of the hip-girdle musculature (HP:0001445)5.73794595
3Abnormality of the musculature of the pelvis (HP:0001469)5.73794595
4Palpebral edema (HP:0100540)4.80579987
5Abnormal respiratory motile cilium physiology (HP:0012261)4.38221191
6Abnormal ciliary motility (HP:0012262)4.34796655
7Septo-optic dysplasia (HP:0100842)3.99157092
8Buphthalmos (HP:0000557)3.91424955
9Abnormality of macular pigmentation (HP:0008002)3.85323314
10Abnormal respiratory motile cilium morphology (HP:0005938)3.68741278
11Abnormal respiratory epithelium morphology (HP:0012253)3.68741278
12Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.63205201
13Hemorrhage of the eye (HP:0011885)3.62435070
14Mask-like facies (HP:0000298)3.56876534
15Rib fusion (HP:0000902)3.55879229
16Visual hallucinations (HP:0002367)3.54157224
17Pendular nystagmus (HP:0012043)3.52201012
18Insomnia (HP:0100785)3.33299910
19Retinal dysplasia (HP:0007973)3.30977788
20Asymmetry of the thorax (HP:0001555)3.22916992
21Anophthalmia (HP:0000528)3.22242221
22Molar tooth sign on MRI (HP:0002419)3.21890031
23Abnormality of midbrain morphology (HP:0002418)3.21890031
24Hypothermia (HP:0002045)3.21767872
25Rhinitis (HP:0012384)3.20762701
26Febrile seizures (HP:0002373)3.13354236
27Atonic seizures (HP:0010819)3.10618484
28Cortical dysplasia (HP:0002539)3.05399157
29Nephronophthisis (HP:0000090)3.01823025
30Foot dorsiflexor weakness (HP:0009027)2.99919040
31Dynein arm defect of respiratory motile cilia (HP:0012255)2.97030815
32Absent/shortened dynein arms (HP:0200106)2.97030815
33Focal seizures (HP:0007359)2.94950490
34Focal motor seizures (HP:0011153)2.94533513
35* Anosmia (HP:0000458)2.90991657
36Pancreatic cysts (HP:0001737)2.90729981
37Hemivertebrae (HP:0002937)2.90074442
38Gait imbalance (HP:0002141)2.89619940
39Sclerocornea (HP:0000647)2.84774068
40Hepatoblastoma (HP:0002884)2.80320723
41Medial flaring of the eyebrow (HP:0010747)2.79628549
42Congenital primary aphakia (HP:0007707)2.69496908
43Facial edema (HP:0000282)2.68024166
44Abnormality of the foot musculature (HP:0001436)2.67955841
45Periorbital edema (HP:0100539)2.67871222
46Absence seizures (HP:0002121)2.66460463
47High anterior hairline (HP:0009890)2.66356638
48Supernumerary spleens (HP:0009799)2.66119898
49Intestinal atresia (HP:0011100)2.64978556
50Vitreoretinal degeneration (HP:0000655)2.63715473
51Dialeptic seizures (HP:0011146)2.63109702
52Optic nerve hypoplasia (HP:0000609)2.62821596
53Postaxial foot polydactyly (HP:0001830)2.62130873
54Chronic sinusitis (HP:0011109)2.58003682
55Colon cancer (HP:0003003)2.57255390
56Congenital glaucoma (HP:0001087)2.57183398
57Facial cleft (HP:0002006)2.54800861
58Limb-girdle muscle weakness (HP:0003325)2.54437524
59Preaxial hand polydactyly (HP:0001177)2.49443129
60Hyperglycinemia (HP:0002154)2.49045320
61Broad foot (HP:0001769)2.46423391
62Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.46017074
63Nephrogenic diabetes insipidus (HP:0009806)2.45757346
64Absent septum pellucidum (HP:0001331)2.44883314
65Chronic hepatic failure (HP:0100626)2.44711998
66Median cleft lip (HP:0000161)2.35519052
67Oligodactyly (hands) (HP:0001180)2.34296092
68Abnormality of the renal medulla (HP:0100957)2.33596027
69Abnormality of dentin (HP:0010299)2.32812664
70Myokymia (HP:0002411)2.30935820
71Postaxial hand polydactyly (HP:0001162)2.29161616
72Stenosis of the external auditory canal (HP:0000402)2.29139509
73Vaginal atresia (HP:0000148)2.29079415
74Multifactorial inheritance (HP:0001426)2.27866423
75Abnormality of the septum pellucidum (HP:0007375)2.24742987
76Cystic liver disease (HP:0006706)2.23119303
77Exercise-induced muscle cramps (HP:0003710)2.22841037
78Holoprosencephaly (HP:0001360)2.22393745
79Maternal diabetes (HP:0009800)2.22384726
80Bifid tongue (HP:0010297)2.21123835
81Aplasia/Hypoplasia of the tongue (HP:0010295)2.19857910
82Abnormality of aromatic amino acid family metabolism (HP:0004338)2.19845728
83Genital tract atresia (HP:0001827)2.18523012
84Abnormality of the labia minora (HP:0012880)2.18041361
85Split foot (HP:0001839)2.15209587
86Abnormal hair whorl (HP:0010721)2.14096451
87Oligodactyly (HP:0012165)2.11065421
88Renovascular hypertension (HP:0100817)2.11064650
89Specific learning disability (HP:0001328)2.11032645
90Congenital hepatic fibrosis (HP:0002612)2.10265474
91Curly hair (HP:0002212)2.10109883
92Vertebral arch anomaly (HP:0008438)2.09650883
93Pancreatic fibrosis (HP:0100732)2.08771819
94Optic nerve coloboma (HP:0000588)2.07581289
95Sex reversal (HP:0012245)2.06860185
96Abnormal sex determination (HP:0012244)2.06860185
97Dandy-Walker malformation (HP:0001305)2.06160267
98Reticulocytopenia (HP:0001896)2.05794718
99Abnormality of the 4th metacarpal (HP:0010012)2.03186916
100Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.02525570
101Short 4th metacarpal (HP:0010044)2.02525570
102Agitation (HP:0000713)2.00534395
103Esophageal atresia (HP:0002032)2.00490847
104Occipital encephalocele (HP:0002085)2.00332809
105Generalized tonic-clonic seizures (HP:0002069)1.99846012
106Diastasis recti (HP:0001540)1.99776659
107Broad thumb (HP:0011304)1.99224792
108Abnormality of the diencephalon (HP:0010662)1.98958774
109* Micropenis (HP:0000054)1.98909923
110Adrenal hypoplasia (HP:0000835)1.98156059
111Chorioretinal coloboma (HP:0000567)1.95975207
112Renal dysplasia (HP:0000110)1.95710214
113Omphalocele (HP:0001539)1.94742727
114Meckel diverticulum (HP:0002245)1.93719395
115Amblyopia (HP:0000646)1.93687039
116Growth hormone deficiency (HP:0000824)1.93607808
117Broad phalanges of the hand (HP:0009768)1.92980483
118Abnormality of the antihelix (HP:0009738)1.91852640
119Thyroid carcinoma (HP:0002890)1.91703419
120Broad alveolar ridges (HP:0000187)1.90998508
121Arterial tortuosity (HP:0005116)1.90680583
122Progressive macrocephaly (HP:0004481)1.89878594
123Abnormality of the ileum (HP:0001549)1.86955284
124Meningioma (HP:0002858)1.85983068
125Trigonocephaly (HP:0000243)1.85925264
126Bile duct proliferation (HP:0001408)1.85547017
127Abnormal biliary tract physiology (HP:0012439)1.85547017
128Syncope (HP:0001279)1.85519781
129Aqueductal stenosis (HP:0002410)1.83695945
130Broad finger (HP:0001500)1.82945015
131Exotropia (HP:0000577)1.82578996
132Narrow forehead (HP:0000341)1.82554956
133Absent eyebrow (HP:0002223)1.81117569
134Anencephaly (HP:0002323)1.80481478
135Male pseudohermaphroditism (HP:0000037)1.80480039
136Drooling (HP:0002307)1.79844160
137Gastrointestinal atresia (HP:0002589)1.79547023
138Partial agenesis of the corpus callosum (HP:0001338)1.78767366
139Hyperglycinuria (HP:0003108)1.78643581
140Multicystic kidney dysplasia (HP:0000003)1.78152023
141Supranuclear gaze palsy (HP:0000605)1.78021655
142Preaxial foot polydactyly (HP:0001841)1.77824093
143Tubulointerstitial nephritis (HP:0001970)1.76863548
144Abnormality of the intervertebral disk (HP:0005108)1.75862776
145Chronic bronchitis (HP:0004469)1.75621794
146Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.75275420
147Ectopic kidney (HP:0000086)1.75199154
148Atresia of the external auditory canal (HP:0000413)1.75176250
149True hermaphroditism (HP:0010459)1.74193662
150Hyperthyroidism (HP:0000836)1.73930669
151Fibular hypoplasia (HP:0003038)1.73339536
152Overlapping toe (HP:0001845)1.73089506
153Lissencephaly (HP:0001339)1.72188303
154Elfin facies (HP:0004428)1.72187089
155Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.71683700
156Abnormality of the aortic arch (HP:0012303)1.71525691
157Palpitations (HP:0001962)1.71490384
158Abnormality of abdominal situs (HP:0011620)1.71363063
159Abdominal situs inversus (HP:0003363)1.71363063
160Broad phalanx (HP:0006009)1.71122332
161Acute necrotizing encephalopathy (HP:0006965)1.69207721
162Poor coordination (HP:0002370)1.67456119
163Intellectual disability, moderate (HP:0002342)1.66906281
164Severe visual impairment (HP:0001141)1.66214999
165Labial hypoplasia (HP:0000066)1.65553418
166Limb dystonia (HP:0002451)1.65450021
167Renal hypoplasia (HP:0000089)1.63218956
168Abnormality of the anterior chamber (HP:0000593)1.63008918
169Neoplasm of the adrenal cortex (HP:0100641)1.62488508
170Abnormal number of incisors (HP:0011064)1.61972509

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB37.11114197
2BMPR24.48297537
3EPHA44.24110967
4MAPK153.68855324
5PHKG23.40509737
6PHKG13.40509737
7BCR3.31325254
8TRIM283.30697446
9PLK43.10861602
10EEF2K3.01860423
11SIK22.79980602
12MAPKAPK32.57551432
13MAP3K92.47376678
14WNK32.30399084
15PNCK2.27682985
16MAPK132.19109384
17MAP4K22.13236786
18MAP2K72.11910134
19DYRK31.87370316
20EPHB21.84607004
21BCKDK1.83945802
22CDC71.82277340
23MAP3K41.78616586
24ZAK1.73702918
25MAP3K61.71293610
26ARAF1.56385125
27MAP3K101.53009933
28TAF11.48874614
29BUB11.47665894
30MKNK11.46620476
31FRK1.40488461
32PLK21.39529680
33RPS6KA41.29924430
34MAP2K41.25108030
35SRPK11.24883379
36MKNK21.24045601
37CSNK1G21.16711417
38CAMK2D1.15958364
39DYRK21.15014477
40CSNK1A1L1.13932844
41BMPR1B1.11507783
42DAPK21.10839586
43EPHA31.10474249
44DYRK1B1.08426844
45NTRK21.08211192
46PLK11.07226592
47STK111.06965619
48NEK21.06889691
49MARK21.06481871
50NTRK31.03490847
51TTK1.02336011
52NEK91.01242395
53NEK11.00468351
54CAMK2B0.97791007
55BRD40.95378691
56CDK90.93399478
57FGFR20.91115466
58CAMK2G0.89522790
59MARK10.87973486
60STK38L0.87765547
61CSNK1G30.83896410
62PINK10.82238657
63STK390.80395338
64VRK10.79222003
65DAPK10.78717462
66NUAK10.77070782
67PBK0.74507448
68CDK30.70572393
69CDK180.69986587
70VRK20.69898978
71MINK10.69859103
72PLK30.69700669
73TGFBR20.69308904
74ERBB20.68340560
75ATR0.68172695
76MAP3K20.68136846
77CASK0.68037231
78CDK11A0.67765847
79UHMK10.67643282
80CHEK20.66654384
81FGFR10.64578326
82CDK190.64303219
83SGK2230.63381598
84SGK4940.63381598
85BRAF0.63148889
86CAMK40.62769066
87CSNK1G10.62694609
88AURKB0.62406994
89SIK30.62386180
90CDK150.61675685
91OXSR10.61238005
92CAMK1G0.59358791
93GRK10.58625283
94TRPM70.57845125
95RIPK10.57517031
96BRSK10.57337893
97RPS6KA20.56342673
98SIK10.56296263
99WEE10.54150279
100DYRK1A0.53824298
101TNIK0.52187189
102PAK30.51946692
103PASK0.50930908
104CAMK1D0.50790257
105WNK40.50515770
106ATM0.49647202
107AURKA0.47912797
108MAPKAPK20.47268663
109CSNK1E0.45781544
110INSRR0.44770324
111PRKCG0.44480200
112SGK20.42657814
113PAK40.40935253
114FER0.40628074
115CAMK2A0.39650755
116CSNK1A10.39150027
117RPS6KB10.38746894
118CDK20.37006603
119PRKCZ0.36844796
120DAPK30.36354045
121CDK50.35384897
122PIM20.35265582
123CAMK10.34845002
124MUSK0.34539481
125CDK10.33185149
126CDK60.31781261
127KSR10.31667592
128LIMK10.30967967
129BRSK20.30736213
130TIE10.30543682
131CHEK10.30201040
132FYN0.28956564
133ROCK20.28047937
134PRKCQ0.26944550
135FES0.26648143
136MAPKAPK50.25373245
137STK380.25033575
138TYRO30.24096109
139EPHA20.22806147
140MAPK70.22637886
141PRKD10.22018856
142PKN10.21419911
143CDK140.20182834
144MAPK90.20149377
145PRKG10.19387116
146GRK70.18917085
147PRKCE0.17718799
148MAPK100.17107156
149ROCK10.16853555
150PAK60.16621343

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047406.87736488
2Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.92168564
3Synaptic vesicle cycle_Homo sapiens_hsa047212.79263076
4Basal cell carcinoma_Homo sapiens_hsa052172.74390060
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.65364474
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.59398012
7Ribosome_Homo sapiens_hsa030102.54412705
8Steroid biosynthesis_Homo sapiens_hsa001002.37743663
9Alcoholism_Homo sapiens_hsa050342.23430427
10Notch signaling pathway_Homo sapiens_hsa043302.18163084
11Protein export_Homo sapiens_hsa030602.10029505
12Fanconi anemia pathway_Homo sapiens_hsa034602.07907892
13Dopaminergic synapse_Homo sapiens_hsa047282.06780204
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.01912312
15Morphine addiction_Homo sapiens_hsa050322.00641450
16SNARE interactions in vesicular transport_Homo sapiens_hsa041301.97319268
17GABAergic synapse_Homo sapiens_hsa047271.92467047
18Spliceosome_Homo sapiens_hsa030401.92199881
19Circadian entrainment_Homo sapiens_hsa047131.89252790
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.88531966
21Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.85388792
22Huntingtons disease_Homo sapiens_hsa050161.85120586
23Non-homologous end-joining_Homo sapiens_hsa034501.84617203
24Nicotine addiction_Homo sapiens_hsa050331.83079156
25Hippo signaling pathway_Homo sapiens_hsa043901.79432939
26Glutamatergic synapse_Homo sapiens_hsa047241.74787444
27Taste transduction_Homo sapiens_hsa047421.70136546
28mRNA surveillance pathway_Homo sapiens_hsa030151.69717294
29Basal transcription factors_Homo sapiens_hsa030221.68432269
30Cholinergic synapse_Homo sapiens_hsa047251.68237695
31Homologous recombination_Homo sapiens_hsa034401.67417714
32Amphetamine addiction_Homo sapiens_hsa050311.66428778
33Insulin secretion_Homo sapiens_hsa049111.65831219
34RNA degradation_Homo sapiens_hsa030181.64679076
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.62193343
36Chronic myeloid leukemia_Homo sapiens_hsa052201.62060312
37Base excision repair_Homo sapiens_hsa034101.60006474
38Phototransduction_Homo sapiens_hsa047441.55003800
39RNA transport_Homo sapiens_hsa030131.54992048
40Serotonergic synapse_Homo sapiens_hsa047261.52677790
41Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.52022485
42Biosynthesis of amino acids_Homo sapiens_hsa012301.48382437
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45924025
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.42769058
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.39414275
46Collecting duct acid secretion_Homo sapiens_hsa049661.37307029
47Wnt signaling pathway_Homo sapiens_hsa043101.35758396
48Cell cycle_Homo sapiens_hsa041101.34452892
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34280816
50DNA replication_Homo sapiens_hsa030301.33446813
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32997063
52Mismatch repair_Homo sapiens_hsa034301.28493487
53GnRH signaling pathway_Homo sapiens_hsa049121.26406630
54Cocaine addiction_Homo sapiens_hsa050301.24135328
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.22715647
56RNA polymerase_Homo sapiens_hsa030201.18570933
57Glucagon signaling pathway_Homo sapiens_hsa049221.14150517
58Adherens junction_Homo sapiens_hsa045201.11961416
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.10422296
60Thyroid hormone signaling pathway_Homo sapiens_hsa049191.09030243
61Axon guidance_Homo sapiens_hsa043601.07686583
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.06511797
63Long-term potentiation_Homo sapiens_hsa047201.05832677
64Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.05826585
65Aldosterone synthesis and secretion_Homo sapiens_hsa049251.00685248
66Pyruvate metabolism_Homo sapiens_hsa006201.00163698
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.98404250
68Gastric acid secretion_Homo sapiens_hsa049710.97989094
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.97359759
70Glioma_Homo sapiens_hsa052140.95503629
71Systemic lupus erythematosus_Homo sapiens_hsa053220.94945550
72Vibrio cholerae infection_Homo sapiens_hsa051100.94812413
73Carbon metabolism_Homo sapiens_hsa012000.93827716
74Prion diseases_Homo sapiens_hsa050200.92283643
75Tight junction_Homo sapiens_hsa045300.91775935
76TGF-beta signaling pathway_Homo sapiens_hsa043500.87970687
77Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87812483
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87609591
79Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.87489951
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87095349
81Fatty acid elongation_Homo sapiens_hsa000620.86475162
82Propanoate metabolism_Homo sapiens_hsa006400.84624377
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.83599620
84Lysine degradation_Homo sapiens_hsa003100.82144064
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81866039
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.81691975
87Arginine and proline metabolism_Homo sapiens_hsa003300.80377870
88Butanoate metabolism_Homo sapiens_hsa006500.80089533
89Oxytocin signaling pathway_Homo sapiens_hsa049210.78642113
90Insulin signaling pathway_Homo sapiens_hsa049100.77642700
91Nucleotide excision repair_Homo sapiens_hsa034200.77500732
92Melanogenesis_Homo sapiens_hsa049160.77490534
93Sulfur relay system_Homo sapiens_hsa041220.76901996
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76757735
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76650319
96Linoleic acid metabolism_Homo sapiens_hsa005910.76385403
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75093624
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73891850
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72938138
100Regulation of autophagy_Homo sapiens_hsa041400.72468152
101Fatty acid metabolism_Homo sapiens_hsa012120.72349776
102Hepatitis C_Homo sapiens_hsa051600.68726260
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68318137
104Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66859423
105Fat digestion and absorption_Homo sapiens_hsa049750.65634112
106Histidine metabolism_Homo sapiens_hsa003400.65362745
107Retinol metabolism_Homo sapiens_hsa008300.64888032
108Bile secretion_Homo sapiens_hsa049760.64664374
109Estrogen signaling pathway_Homo sapiens_hsa049150.64176487
110cAMP signaling pathway_Homo sapiens_hsa040240.63073678
111Folate biosynthesis_Homo sapiens_hsa007900.62805796
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62020734
113FoxO signaling pathway_Homo sapiens_hsa040680.61293859
114Calcium signaling pathway_Homo sapiens_hsa040200.61106555
115Peroxisome_Homo sapiens_hsa041460.60332086
1162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.59001821
117beta-Alanine metabolism_Homo sapiens_hsa004100.58784437
118Oxidative phosphorylation_Homo sapiens_hsa001900.57364737
119Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57094589
120Viral carcinogenesis_Homo sapiens_hsa052030.56673845
121Gap junction_Homo sapiens_hsa045400.56587002
122Tryptophan metabolism_Homo sapiens_hsa003800.56107319
123Renin secretion_Homo sapiens_hsa049240.55571134
124Primary bile acid biosynthesis_Homo sapiens_hsa001200.55154086
125Nitrogen metabolism_Homo sapiens_hsa009100.54353143
126Metabolic pathways_Homo sapiens_hsa011000.54234757
127Colorectal cancer_Homo sapiens_hsa052100.53980644
128Tuberculosis_Homo sapiens_hsa051520.53742399
129Long-term depression_Homo sapiens_hsa047300.53453578
130Fatty acid degradation_Homo sapiens_hsa000710.53310407
131ErbB signaling pathway_Homo sapiens_hsa040120.53107162
132Cardiac muscle contraction_Homo sapiens_hsa042600.52655571
133ABC transporters_Homo sapiens_hsa020100.52348117
134Ras signaling pathway_Homo sapiens_hsa040140.52091901
135Alzheimers disease_Homo sapiens_hsa050100.49333523
136Ether lipid metabolism_Homo sapiens_hsa005650.49079812
137Salivary secretion_Homo sapiens_hsa049700.49065769
138Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48810488
139Parkinsons disease_Homo sapiens_hsa050120.48613328
140Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48080308
141Pyrimidine metabolism_Homo sapiens_hsa002400.47928623
142Vitamin B6 metabolism_Homo sapiens_hsa007500.47008278
143Ovarian steroidogenesis_Homo sapiens_hsa049130.45991764
144Hedgehog signaling pathway_Homo sapiens_hsa043400.45874833
145Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43926270
146Purine metabolism_Homo sapiens_hsa002300.41467553
147Endometrial cancer_Homo sapiens_hsa052130.41384814
148Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.39391721
149Pancreatic cancer_Homo sapiens_hsa052120.36946793
150Viral myocarditis_Homo sapiens_hsa054160.35906111
151Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35571348
152Type II diabetes mellitus_Homo sapiens_hsa049300.35041844
153Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34617863
154Maturity onset diabetes of the young_Homo sapiens_hsa049500.34217975
155Thyroid hormone synthesis_Homo sapiens_hsa049180.33691613
156p53 signaling pathway_Homo sapiens_hsa041150.31478591
157Pathways in cancer_Homo sapiens_hsa052000.31464954
158AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.31279931
159Dorso-ventral axis formation_Homo sapiens_hsa043200.30387700
160Selenocompound metabolism_Homo sapiens_hsa004500.29764042
161Oocyte meiosis_Homo sapiens_hsa041140.29738710

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »