FFAR4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and insulin sensitizing. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)6.66828854
2Golgi transport vesicle coating (GO:0048200)6.66828854
3positive regulation of vesicle fusion (GO:0031340)5.35566658
4positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003575.27387007
5antigen processing and presentation of endogenous antigen (GO:0019883)5.14053816
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.98678924
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.98678924
8fucose catabolic process (GO:0019317)4.72192175
9L-fucose metabolic process (GO:0042354)4.72192175
10L-fucose catabolic process (GO:0042355)4.72192175
11signal peptide processing (GO:0006465)4.71632631
12behavioral response to nicotine (GO:0035095)4.68030135
13endocrine pancreas development (GO:0031018)4.55609344
14peptide hormone processing (GO:0016486)4.47191752
15positive regulation of insulin secretion (GO:0032024)4.44347817
16maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.34964496
17retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.29383318
18cellular ketone body metabolic process (GO:0046950)4.27877449
19regulation of T-helper 2 cell differentiation (GO:0045628)4.08090933
20positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.00189244
21response to dietary excess (GO:0002021)3.98551380
22ketone body metabolic process (GO:1902224)3.94368038
23regulation of T-helper 1 cell differentiation (GO:0045625)3.92638945
24protein retention in ER lumen (GO:0006621)3.92077967
25positive regulation of interleukin-12 production (GO:0032735)3.77859518
26positive regulation of type 2 immune response (GO:0002830)3.77038386
27DNA deamination (GO:0045006)3.76576185
28positive regulation of peptide hormone secretion (GO:0090277)3.73404241
29regulation of activation of Janus kinase activity (GO:0010533)3.73297494
30glandular epithelial cell differentiation (GO:0002067)3.71991759
31sequestering of metal ion (GO:0051238)3.69849175
32detection of light stimulus involved in sensory perception (GO:0050962)3.67461987
33detection of light stimulus involved in visual perception (GO:0050908)3.67461987
34water-soluble vitamin biosynthetic process (GO:0042364)3.66294486
35production of molecular mediator involved in inflammatory response (GO:0002532)3.63167025
36kynurenine metabolic process (GO:0070189)3.58297019
37regulation of type B pancreatic cell apoptotic process (GO:2000674)3.57880605
38cellular response to vitamin D (GO:0071305)3.57165962
39indolalkylamine metabolic process (GO:0006586)3.55626708
40regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.55293741
41positive regulation of peptide secretion (GO:0002793)3.55250454
42regulation of glucokinase activity (GO:0033131)3.53701522
43regulation of hexokinase activity (GO:1903299)3.53701522
44kidney morphogenesis (GO:0060993)3.48417794
45indole-containing compound catabolic process (GO:0042436)3.48077439
46indolalkylamine catabolic process (GO:0046218)3.48077439
47tryptophan catabolic process (GO:0006569)3.48077439
48response to pheromone (GO:0019236)3.42421498
49COPII vesicle coating (GO:0048208)3.39271434
50L-alpha-amino acid transmembrane transport (GO:1902475)3.39105949
51piRNA metabolic process (GO:0034587)3.37999893
52growth hormone receptor signaling pathway (GO:0060396)3.37310732
53platelet dense granule organization (GO:0060155)3.36540906
54detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.35180759
55regulation of immunoglobulin secretion (GO:0051023)3.34866902
56neutrophil activation involved in immune response (GO:0002283)3.32335076
57axoneme assembly (GO:0035082)3.25868738
58eosinophil chemotaxis (GO:0048245)3.22285934
59cellular response to type I interferon (GO:0071357)3.20620819
60type I interferon signaling pathway (GO:0060337)3.20620819
61primary amino compound metabolic process (GO:1901160)3.19414236
62regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)3.18709829
63response to type I interferon (GO:0034340)3.17312689
64positive regulation of T-helper cell differentiation (GO:0045624)3.15900012
65respiratory chain complex IV assembly (GO:0008535)3.14601807
66myeloid dendritic cell differentiation (GO:0043011)3.12905451
67regulation of RIG-I signaling pathway (GO:0039535)3.10489416
68T-helper 1 type immune response (GO:0042088)3.10285384
69negative regulation of execution phase of apoptosis (GO:1900118)3.09964484
70epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.09789875
71regulation of dendritic cell antigen processing and presentation (GO:0002604)3.05590761
72indole-containing compound metabolic process (GO:0042430)3.03963275
73tryptophan metabolic process (GO:0006568)3.03872496
74regulation of insulin secretion (GO:0050796)3.01077118
75regulation of action potential (GO:0098900)3.00189706
76positive regulation of hormone secretion (GO:0046887)2.99513698
77preassembly of GPI anchor in ER membrane (GO:0016254)2.96985111
78cellular response to vitamin (GO:0071295)2.96576987
79positive regulation of respiratory burst (GO:0060267)2.96537698
80response to lipoprotein particle (GO:0055094)2.96173755
81negative regulation of digestive system process (GO:0060457)2.95738541
82positive regulation of monocyte chemotaxis (GO:0090026)2.95323295
83regulation of T cell tolerance induction (GO:0002664)2.93197031
84positive regulation of interferon-alpha production (GO:0032727)2.92355419
85glycerophospholipid catabolic process (GO:0046475)2.92282046
86adaptation of signaling pathway (GO:0023058)2.92249674
87serotonin metabolic process (GO:0042428)2.92060140
88regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.91384747
89negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.90280019
90epithelial cilium movement (GO:0003351)2.89890471
91toxin transport (GO:1901998)2.88934657
92negative regulation of JUN kinase activity (GO:0043508)2.86630012
93negative regulation of erythrocyte differentiation (GO:0045647)2.84432146
94low-density lipoprotein particle clearance (GO:0034383)2.84233125
95positive regulation of amino acid transport (GO:0051957)2.84010049
96DNA methylation involved in gamete generation (GO:0043046)2.82915378
97cellular response to growth hormone stimulus (GO:0071378)2.82534976
98protein autoprocessing (GO:0016540)2.82445603
99protein localization to cilium (GO:0061512)2.81382171
100amyloid precursor protein catabolic process (GO:0042987)2.81067083
101synaptic transmission, cholinergic (GO:0007271)2.80065693
102toxin metabolic process (GO:0009404)2.79891624
103eosinophil migration (GO:0072677)2.77730657
104regulation of peptide hormone secretion (GO:0090276)2.77576106
105insulin secretion (GO:0030073)2.77107094
106negative regulation of mast cell activation (GO:0033004)2.76783013
107astrocyte differentiation (GO:0048708)2.76250687
108positive regulation of peptidyl-threonine phosphorylation (GO:0010800)2.76244257
109neuronal action potential (GO:0019228)2.76015986
110protein complex biogenesis (GO:0070271)2.74388909
111regulation of peptide secretion (GO:0002791)2.73947139
112glycine transport (GO:0015816)2.73699624
113regulation of memory T cell differentiation (GO:0043380)2.73479674
114negative regulation of interleukin-17 production (GO:0032700)2.73210010
115nitric oxide biosynthetic process (GO:0006809)2.72595531
116cytochrome complex assembly (GO:0017004)2.71004408
117nitric oxide mediated signal transduction (GO:0007263)2.69663989
118regulation of interferon-alpha production (GO:0032647)2.69337080
119neutrophil activation (GO:0042119)2.69279662
120peptide catabolic process (GO:0043171)2.69046292
121surfactant homeostasis (GO:0043129)2.68897034
122negative regulation of telomere maintenance (GO:0032205)2.68616197
123neuron fate specification (GO:0048665)2.67851326
124protein K11-linked deubiquitination (GO:0035871)2.67466376
125fucosylation (GO:0036065)2.66825685
126response to prostaglandin E (GO:0034695)2.66676289
127regulation of cholesterol storage (GO:0010885)2.65326779
128myeloid dendritic cell activation (GO:0001773)2.64776431
129reflex (GO:0060004)2.64371333
130neural tube formation (GO:0001841)2.62522677
131granulocyte activation (GO:0036230)2.62400353
132gamma-aminobutyric acid transport (GO:0015812)2.61940802
133negative regulation of multicellular organism growth (GO:0040015)2.61833381
134inositol phosphate catabolic process (GO:0071545)2.60612689
135hydrogen peroxide biosynthetic process (GO:0050665)2.59591635
136regulation of interleukin-8 secretion (GO:2000482)2.59388988
137positive regulation of antigen processing and presentation (GO:0002579)2.59301911
138positive regulation of glycolytic process (GO:0045821)2.59050073
139protein polyglutamylation (GO:0018095)2.58957921
140positive regulation of natural killer cell differentiation (GO:0032825)2.58905675
141phosphatidylinositol acyl-chain remodeling (GO:0036149)2.58531004
142mannosylation (GO:0097502)2.57699331
143regulation of T-helper cell differentiation (GO:0045622)2.57379461
144vesicle coating (GO:0006901)2.56683190
145negative regulation of glycoprotein metabolic process (GO:1903019)2.56360249
146magnesium ion transport (GO:0015693)2.55714788
147retinal metabolic process (GO:0042574)2.54454453
148sexual reproduction (GO:0019953)2.53655397
149multicellular organism reproduction (GO:0032504)2.53410725
150membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.53298041
151negative regulation of synaptic transmission, GABAergic (GO:0032229)2.52476766
152mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.52473711
153mitochondrial respiratory chain complex I assembly (GO:0032981)2.52473711
154NADH dehydrogenase complex assembly (GO:0010257)2.52473711
155regulation of extracellular matrix disassembly (GO:0010715)2.50565141
156acrosome assembly (GO:0001675)2.50309230
157pharyngeal system development (GO:0060037)2.49378191
158auditory receptor cell stereocilium organization (GO:0060088)2.48888807
159positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.48832735
160antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.48376838
161positive regulation of glycoprotein metabolic process (GO:1903020)2.48254333
162peptide hormone secretion (GO:0030072)2.47856452
163maintenance of gastrointestinal epithelium (GO:0030277)2.47117110
164regulation of hormone secretion (GO:0046883)2.47096523
165nucleobase catabolic process (GO:0046113)2.46619220
166retinal cone cell development (GO:0046549)2.45694350
167behavioral response to ethanol (GO:0048149)2.45236865
168mitochondrial respiratory chain complex assembly (GO:0033108)2.43737133
169polyol catabolic process (GO:0046174)2.43277460
170regulation of rhodopsin mediated signaling pathway (GO:0022400)2.43229435
171startle response (GO:0001964)2.40821056
172nonmotile primary cilium assembly (GO:0035058)2.40367534
173cellular biogenic amine catabolic process (GO:0042402)2.40124877
174amine catabolic process (GO:0009310)2.40124877
175sperm motility (GO:0030317)2.40075554
176photoreceptor cell maintenance (GO:0045494)2.39552059
177pyrimidine nucleobase catabolic process (GO:0006208)2.38640786
178action potential (GO:0001508)2.38544492
179adenosine metabolic process (GO:0046085)2.38144684
180rhodopsin mediated signaling pathway (GO:0016056)2.37562297
181proline transport (GO:0015824)2.36213103
182benzene-containing compound metabolic process (GO:0042537)2.35978880
183cilium morphogenesis (GO:0060271)2.35464634
184negative regulation of protein oligomerization (GO:0032460)2.35421820
185dopamine transport (GO:0015872)2.34229886
186nephron tubule morphogenesis (GO:0072078)2.33895248
187nephron epithelium morphogenesis (GO:0072088)2.33895248
188positive regulation of meiosis (GO:0045836)2.32616860
189G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.31313642
190cilium movement (GO:0003341)2.31076164
191peristalsis (GO:0030432)2.29921794
192L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.29215331
193rRNA catabolic process (GO:0016075)2.29140780
194membrane repolarization during action potential (GO:0086011)2.27989594
195phosphorylated carbohydrate dephosphorylation (GO:0046838)2.27631342
196inositol phosphate dephosphorylation (GO:0046855)2.27631342

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.15191409
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.28958113
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.82236198
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.68365576
5ZNF274_21170338_ChIP-Seq_K562_Hela3.66614829
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.62295438
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.43457231
8VDR_22108803_ChIP-Seq_LS180_Human3.24023976
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.23287455
10GBX2_23144817_ChIP-Seq_PC3_Human3.00224447
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.80705457
12RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.76656814
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.70547229
14STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.57290611
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.54302487
16GATA1_22025678_ChIP-Seq_K562_Human2.48702355
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.47863271
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.47472135
19EZH2_22144423_ChIP-Seq_EOC_Human2.26156483
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.25042248
21IRF8_27001747_Chip-Seq_BMDM_Mouse2.24342630
22SOX2_20726797_ChIP-Seq_SW620_Human2.18218928
23CTBP2_25329375_ChIP-Seq_LNCAP_Human2.16539934
24IGF1R_20145208_ChIP-Seq_DFB_Human2.15185268
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.15146020
26FLI1_27457419_Chip-Seq_LIVER_Mouse2.08190211
27CTBP1_25329375_ChIP-Seq_LNCAP_Human2.04773657
28PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.03818552
29IKZF1_21737484_ChIP-ChIP_HCT116_Human2.00381663
30CLOCK_20551151_ChIP-Seq_293T_Human1.94520185
31FUS_26573619_Chip-Seq_HEK293_Human1.94343469
32ER_23166858_ChIP-Seq_MCF-7_Human1.92495788
33P300_19829295_ChIP-Seq_ESCs_Human1.90496045
34Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.87360893
35SOX2_27498859_Chip-Seq_STOMACH_Mouse1.86867127
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.85454733
37TAF15_26573619_Chip-Seq_HEK293_Human1.85035240
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.84442848
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.81255402
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.78039634
41EWS_26573619_Chip-Seq_HEK293_Human1.77137783
42BCAT_22108803_ChIP-Seq_LS180_Human1.75712531
43LXR_22158963_ChIP-Seq_LIVER_Mouse1.73675383
44SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.73124012
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.72927612
46FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.70908717
47STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.70686215
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68165784
49ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.66636715
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64594760
51RXR_22158963_ChIP-Seq_LIVER_Mouse1.63983740
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.60897175
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.60713169
54ESR1_21235772_ChIP-Seq_MCF-7_Human1.60671367
55* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.59856802
56BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.57838920
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56019337
58STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.55687128
59CBP_20019798_ChIP-Seq_JUKART_Human1.55519694
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.55519694
61TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55153688
62ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.53651697
63PPARA_22158963_ChIP-Seq_LIVER_Mouse1.52758767
64GATA4_25053715_ChIP-Seq_YYC3_Human1.51986280
65AR_25329375_ChIP-Seq_VCAP_Human1.51930761
66HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.49553503
67STAT3_23295773_ChIP-Seq_U87_Human1.47550588
68EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.45314398
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45129192
70REST_21632747_ChIP-Seq_MESCs_Mouse1.43714826
71SMAD4_21799915_ChIP-Seq_A2780_Human1.43681953
72TP53_22573176_ChIP-Seq_HFKS_Human1.42795075
73TCF4_23295773_ChIP-Seq_U87_Human1.42511859
74FOXA1_27270436_Chip-Seq_PROSTATE_Human1.41537320
75FOXA1_25329375_ChIP-Seq_VCAP_Human1.41537320
76STAT4_19710469_ChIP-ChIP_TH1__Mouse1.41100522
77NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.41015977
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40695725
79NR3C1_21868756_ChIP-Seq_MCF10A_Human1.39817866
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38795065
81SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.38002743
82CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37429903
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36559061
84TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34756922
85TCF4_22108803_ChIP-Seq_LS180_Human1.34391826
86BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34354538
87NANOG_19829295_ChIP-Seq_ESCs_Human1.33804142
88SOX2_19829295_ChIP-Seq_ESCs_Human1.33804142
89SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32477831
90FOXA1_25552417_ChIP-Seq_VCAP_Human1.31964351
91EGR1_19374776_ChIP-ChIP_THP-1_Human1.30755552
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30222454
93POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30222454
94FOXA1_21572438_ChIP-Seq_LNCaP_Human1.30011796
95NFE2_27457419_Chip-Seq_LIVER_Mouse1.29977963
96SMAD3_21741376_ChIP-Seq_EPCs_Human1.29703513
97CBX2_27304074_Chip-Seq_ESCs_Mouse1.29524757
98CDX2_22108803_ChIP-Seq_LS180_Human1.28217676
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27878486
100ETV2_25802403_ChIP-Seq_MESCs_Mouse1.27229415
101NRF2_20460467_ChIP-Seq_MEFs_Mouse1.26830173
102NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.26830173
103PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26356610
104PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26308785
105GATA3_21878914_ChIP-Seq_MCF-7_Human1.26182826
106KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25370785
107RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24791400
108NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24531109
109NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.24439077
110MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.24320563
111RARG_19884340_ChIP-ChIP_MEFs_Mouse1.23716485
112GATA3_27048872_Chip-Seq_THYMUS_Human1.23572336
113IRF1_19129219_ChIP-ChIP_H3396_Human1.23540546
114SMAD4_21741376_ChIP-Seq_EPCs_Human1.23520817
115RUNX2_22187159_ChIP-Seq_PCA_Human1.23171209
116TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23013352
117NCOR_22424771_ChIP-Seq_293T_Human1.22941310
118HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22614529
119EZH2_27294783_Chip-Seq_NPCs_Mouse1.22133733
120PRDM14_20953172_ChIP-Seq_ESCs_Human1.21615205
121EGR1_23403033_ChIP-Seq_LIVER_Mouse1.19692396
122AR_20517297_ChIP-Seq_VCAP_Human1.19365208
123GATA2_21666600_ChIP-Seq_HMVEC_Human1.17806644
124SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16639276
125VDR_24787735_ChIP-Seq_THP-1_Human1.16180058
126TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.15585145
127FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.15460492
128NANOG_18555785_Chip-Seq_ESCs_Mouse1.14378788
129CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12794396
130NOTCH1_21737748_ChIP-Seq_TLL_Human1.12711490
131CRX_20693478_ChIP-Seq_RETINA_Mouse1.10976326
132BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10264807
133TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10239286
134MYB_21317192_ChIP-Seq_ERMYB_Mouse1.10222205
135CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09890765
136EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09378523
137MYB_26560356_Chip-Seq_TH2_Human1.08711239
138MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07957082
139P63_26484246_Chip-Seq_KERATINOCYTES_Human1.07547722
140FLI1_21867929_ChIP-Seq_TH2_Mouse1.07141630
141NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.06418364
142E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.06134189
143P53_22387025_ChIP-Seq_ESCs_Mouse1.05712428
144OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05568373
145MYC_18940864_ChIP-ChIP_HL60_Human1.05550340
146SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.04805283
147PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04680057
148HOXB7_26014856_ChIP-Seq_BT474_Human1.04636422
149ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04318499
150FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.03516706
151SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02843046
152GATA3_24758297_ChIP-Seq_MCF-7_Human1.00723877
153GABP_17652178_ChIP-ChIP_JURKAT_Human1.00194627
154TAL1_26923725_Chip-Seq_HPCs_Mouse1.00118299
155DROSHA_22980978_ChIP-Seq_HELA_Human0.99409571
156STAT3_18555785_Chip-Seq_ESCs_Mouse0.99046296
157ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98882021
158FOXO3_23340844_ChIP-Seq_DLD1_Human0.97916619
159TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97807877
160SPI1_23127762_ChIP-Seq_K562_Human0.97605232
161TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97522034
162GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.97271416
163REST_18959480_ChIP-ChIP_MESCs_Mouse0.97247421
164MYC_19829295_ChIP-Seq_ESCs_Human0.95735159
165SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.95607224
166CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94290658
167ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.93008771
168CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92234183
169GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.91842562
170DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90693018
171MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.90145131
172GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.89637007
173ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.89493621
174GATA3_26560356_Chip-Seq_TH2_Human0.89306086
175AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.88113526
176FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.87916837
177ZNF217_24962896_ChIP-Seq_MCF-7_Human0.87718892
178ESR2_21235772_ChIP-Seq_MCF-7_Human0.87427546
179PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83637963
180OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.82754510
181SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.80845504
182SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.80845504
183ELK1_22589737_ChIP-Seq_MCF10A_Human0.80258221
184CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.76366939
185GATA6_25053715_ChIP-Seq_YYC3_Human0.75752696
186PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.74263976
187TBX20_22080862_ChIP-Seq_HEART_Mouse0.74001691
188TBX20_22328084_ChIP-Seq_HEART_Mouse0.74001691
189SPI1_23547873_ChIP-Seq_NB4_Human0.73992884
190HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.72793645
191LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.70818978
192CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.70810022
193E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.70338286
194SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70238927
195PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.69952572

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000013_abnormal_adipose_tissue4.77007163
2MP0005379_endocrine/exocrine_gland_phen4.09593022
3MP0002138_abnormal_hepatobiliary_system3.91981207
4MP0002877_abnormal_melanocyte_morpholog3.77521930
5MP0002163_abnormal_gland_morphology3.48194526
6MP0003183_abnormal_peptide_metabolism3.40081210
7MP0003195_calcinosis3.28485533
8MP0000569_abnormal_digit_pigmentation3.25729614
9MP0001835_abnormal_antigen_presentation3.02212948
10MP0008877_abnormal_DNA_methylation2.81915336
11MP0002693_abnormal_pancreas_physiology2.79024711
12MP0003787_abnormal_imprinting2.68060032
13MP0001944_abnormal_pancreas_morphology2.59521097
14MP0000003_abnormal_adipose_tissue2.58209924
15MP0010386_abnormal_urinary_bladder2.54757607
16MP0005645_abnormal_hypothalamus_physiol2.53452752
17MP0002909_abnormal_adrenal_gland2.52383825
18MP0002102_abnormal_ear_morphology2.49059911
19MP0005551_abnormal_eye_electrophysiolog2.34780011
20MP0000678_abnormal_parathyroid_gland2.26840064
21MP0000685_abnormal_immune_system2.25733467
22MP0002148_abnormal_hypersensitivity_rea2.15113332
23MP0003724_increased_susceptibility_to2.12674721
24MP0005084_abnormal_gallbladder_morpholo2.08123314
25MP0004147_increased_porphyrin_level2.07719774
26MP0004782_abnormal_surfactant_physiolog2.03458037
27MP0003283_abnormal_digestive_organ2.02635398
28MP0001348_abnormal_lacrimal_gland2.00566454
29MP0005387_immune_system_phenotype1.96825209
30MP0001790_abnormal_immune_system1.96825209
31MP0005646_abnormal_pituitary_gland1.94224985
32MP0009785_altered_susceptibility_to1.93299296
33MP0003878_abnormal_ear_physiology1.91596548
34MP0005377_hearing/vestibular/ear_phenot1.91596548
35MP0001501_abnormal_sleep_pattern1.90269107
36MP0002837_dystrophic_cardiac_calcinosis1.86822753
37MP0009745_abnormal_behavioral_response1.86144003
38MP0001968_abnormal_touch/_nociception1.85668214
39MP0008875_abnormal_xenobiotic_pharmacok1.84873976
40MP0008872_abnormal_physiological_respon1.84755413
41MP0002078_abnormal_glucose_homeostasis1.82082513
42MP0005220_abnormal_exocrine_pancreas1.74048603
43MP0002139_abnormal_hepatobiliary_system1.73523611
44MP0005058_abnormal_lysosome_morphology1.73383649
45MP0003011_delayed_dark_adaptation1.73331108
46MP0005257_abnormal_intraocular_pressure1.73316363
47MP0004885_abnormal_endolymph1.72083998
48MP0009046_muscle_twitch1.70631600
49MP0003191_abnormal_cellular_cholesterol1.70033495
50MP0003959_abnormal_lean_body1.68832754
51MP0002272_abnormal_nervous_system1.68095979
52MP0005375_adipose_tissue_phenotype1.66730946
53MP0005365_abnormal_bile_salt1.66107540
54MP0004043_abnormal_pH_regulation1.64300422
55MP0004264_abnormal_extraembryonic_tissu1.63876597
56MP0005253_abnormal_eye_physiology1.63693833
57MP0001485_abnormal_pinna_reflex1.60634999
58MP0003646_muscle_fatigue1.59948342
59MP0005310_abnormal_salivary_gland1.59871876
60MP0001756_abnormal_urination1.58963009
61MP0001486_abnormal_startle_reflex1.54965695
62MP0003436_decreased_susceptibility_to1.54226972
63MP0000427_abnormal_hair_cycle1.50654704
64MP0002736_abnormal_nociception_after1.50091726
65MP0002876_abnormal_thyroid_physiology1.48380594
66MP0000613_abnormal_salivary_gland1.47771799
67MP0005000_abnormal_immune_tolerance1.46138689
68MP0000372_irregular_coat_pigmentation1.46116577
69MP0005671_abnormal_response_to1.43768169
70MP0002733_abnormal_thermal_nociception1.42142442
71MP0004185_abnormal_adipocyte_glucose1.41559025
72MP0004019_abnormal_vitamin_homeostasis1.41478384
73MP0009840_abnormal_foam_cell1.38751994
74MP0005174_abnormal_tail_pigmentation1.36397310
75MP0002166_altered_tumor_susceptibility1.35302168
76MP0004142_abnormal_muscle_tone1.35089433
77MP0002735_abnormal_chemical_nociception1.34539240
78MP0001970_abnormal_pain_threshold1.33683885
79MP0002064_seizures1.30933830
80MP0008961_abnormal_basal_metabolism1.29101040
81MP0009643_abnormal_urine_homeostasis1.28133577
82MP0005075_abnormal_melanosome_morpholog1.28009539
83MP0002971_abnormal_brown_adipose1.27117943
84MP0005025_abnormal_response_to1.25670784
85MP0004510_myositis1.23355583
86MP0000631_abnormal_neuroendocrine_gland1.21496286
87MP0002572_abnormal_emotion/affect_behav1.20141218
88MP0001765_abnormal_ion_homeostasis1.19872224
89MP0003880_abnormal_central_pattern1.18921216
90MP0002638_abnormal_pupillary_reflex1.17018661
91MP0006276_abnormal_autonomic_nervous1.16664985
92MP0005410_abnormal_fertilization1.16639977
93MP0005408_hypopigmentation1.16373069
94MP0004215_abnormal_myocardial_fiber1.15889071
95MP0005167_abnormal_blood-brain_barrier1.15669587
96MP0002928_abnormal_bile_duct1.15422603
97MP0006054_spinal_hemorrhage1.15313136
98MP0001905_abnormal_dopamine_level1.15038449
99MP0006292_abnormal_olfactory_placode1.14883735
100MP0002419_abnormal_innate_immunity1.14598364
101MP0002557_abnormal_social/conspecific_i1.14018580
102MP0003122_maternal_imprinting1.13716709
103MP0003137_abnormal_impulse_conducting1.13677867
104MP0005386_behavior/neurological_phenoty1.12761383
105MP0004924_abnormal_behavior1.12761383
106MP0004133_heterotaxia1.12478253
107MP0004130_abnormal_muscle_cell1.12019738
108MP0010234_abnormal_vibrissa_follicle1.11978904
109MP0005083_abnormal_biliary_tract1.11724078
110MP0005670_abnormal_white_adipose1.07113621
111MP0004742_abnormal_vestibular_system1.05898725
112MP0005389_reproductive_system_phenotype1.05534519
113MP0002229_neurodegeneration1.03127111
114MP0002160_abnormal_reproductive_system1.02177775
115MP0002723_abnormal_immune_serum1.01619770
116MP0001346_abnormal_lacrimal_gland1.00756310
117MP0003136_yellow_coat_color1.00599436
118MP0002653_abnormal_ependyma_morphology0.99704811
119MP0000383_abnormal_hair_follicle0.99488809
120MP0005448_abnormal_energy_balance0.99465350
121MP0002452_abnormal_antigen_presenting0.99419993
122MP0005636_abnormal_mineral_homeostasis0.99387309
123MP0002118_abnormal_lipid_homeostasis0.99091079
124MP0005334_abnormal_fat_pad0.98067703
125MP0002067_abnormal_sensory_capabilities0.96963141
126MP0003635_abnormal_synaptic_transmissio0.96292508
127MP0008469_abnormal_protein_level0.95997137
128MP0001845_abnormal_inflammatory_respons0.95544487
129MP0002006_tumorigenesis0.95368492
130MP0001984_abnormal_olfaction0.94868431
131MP0003121_genomic_imprinting0.93608122
132MP0010329_abnormal_lipoprotein_level0.92854071
133MP0003953_abnormal_hormone_level0.92687214
134MP0003300_gastrointestinal_ulcer0.91371579
135MP0002734_abnormal_mechanical_nocicepti0.90469763
136MP0006082_CNS_inflammation0.90337987
137MP0006072_abnormal_retinal_apoptosis0.89794562
138MP0001324_abnormal_eye_pigmentation0.89672991
139MP0000230_abnormal_systemic_arterial0.89125526
140MP0001533_abnormal_skeleton_physiology0.88784642
141MP0001764_abnormal_homeostasis0.88359187
142MP0001919_abnormal_reproductive_system0.88312829
143MP0001819_abnormal_immune_cell0.87332326
144MP0005666_abnormal_adipose_tissue0.86600574
145MP0008775_abnormal_heart_ventricle0.85843291
146MP0002063_abnormal_learning/memory/cond0.85695618
147MP0003172_abnormal_lysosome_physiology0.84949746
148MP0001853_heart_inflammation0.84373217
149MP0002277_abnormal_respiratory_mucosa0.83759440
150MP0001986_abnormal_taste_sensitivity0.83676075
151MP0009780_abnormal_chondrocyte_physiolo0.83273809
152MP0005535_abnormal_body_temperature0.83258856
153MP0005195_abnormal_posterior_eye0.82668600
154MP0005085_abnormal_gallbladder_physiolo0.82423366
155MP0005647_abnormal_sex_gland0.81958618
156MP0000026_abnormal_inner_ear0.80823066
157MP0002420_abnormal_adaptive_immunity0.80566696
158MP0003866_abnormal_defecation0.79478757
159MP0005076_abnormal_cell_differentiation0.79411590
160MP0002090_abnormal_vision0.77764040
161MP0010678_abnormal_skin_adnexa0.77282454
162MP0003252_abnormal_bile_duct0.74701437
163MP0000609_abnormal_liver_physiology0.73051034
164MP0003045_fibrosis0.72961811
165MP0002938_white_spotting0.72735687
166MP0001800_abnormal_humoral_immune0.71604382
167MP0002136_abnormal_kidney_physiology0.71165733
168MP0010155_abnormal_intestine_physiology0.68367840
169MP0004947_skin_inflammation0.67565703
170MP0005332_abnormal_amino_acid0.66820183

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)6.64415316
2Hypoglycemic seizures (HP:0002173)6.52929460
3Hyperinsulinemic hypoglycemia (HP:0000825)6.35023600
4Elevated circulating parathyroid hormone (PTH) level (HP:0003165)5.53412206
5Symptomatic seizures (HP:0011145)5.49971799
6Hyperglycemia (HP:0003074)4.71969155
7Retinal atrophy (HP:0001105)4.62042496
8Congenital stationary night blindness (HP:0007642)4.23449799
9Late onset (HP:0003584)4.23342013
10Abnormality of calcium-phosphate metabolism (HP:0100530)4.19876370
11Ketoacidosis (HP:0001993)3.89970023
12Pancreatic cysts (HP:0001737)3.88173310
13Increased IgM level (HP:0003496)3.67836972
14Insulin-resistant diabetes mellitus (HP:0000831)3.56230081
15Pancreatic islet-cell hyperplasia (HP:0004510)3.56055996
16Nephronophthisis (HP:0000090)3.55531933
17Hyperparathyroidism (HP:0000843)3.52769534
18Abnormality of midbrain morphology (HP:0002418)3.50554072
19Molar tooth sign on MRI (HP:0002419)3.50554072
20Pancreatic fibrosis (HP:0100732)3.46387103
21Abnormality of aromatic amino acid family metabolism (HP:0004338)3.46267896
22Abnormality of the pancreatic islet cells (HP:0006476)3.39765535
23Abnormality of endocrine pancreas physiology (HP:0012093)3.39765535
24Pendular nystagmus (HP:0012043)3.27084904
25True hermaphroditism (HP:0010459)3.23895681
26Vacuolated lymphocytes (HP:0001922)3.21423727
27Abnormality of the renal medulla (HP:0100957)3.06058760
28Hypercortisolism (HP:0001578)3.05682745
29Abnormality of the renal cortex (HP:0011035)3.02305816
30Hyperventilation (HP:0002883)3.00597758
31Dysostosis multiplex (HP:0000943)2.99223965
32Type II lissencephaly (HP:0007260)2.98376780
33Attenuation of retinal blood vessels (HP:0007843)2.94991482
34Interstitial pulmonary disease (HP:0006530)2.94323689
35Abolished electroretinogram (ERG) (HP:0000550)2.90150675
36Large for gestational age (HP:0001520)2.88752357
37Growth hormone excess (HP:0000845)2.86235358
38Eczematoid dermatitis (HP:0000976)2.84592028
39Abnormal drinking behavior (HP:0030082)2.81387950
40Polydipsia (HP:0001959)2.81387950
41Abnormal rod and cone electroretinograms (HP:0008323)2.78833184
42Autoimmune thrombocytopenia (HP:0001973)2.76061007
43Progressive cerebellar ataxia (HP:0002073)2.74841939
44Hyperphosphatemia (HP:0002905)2.72538978
45Gout (HP:0001997)2.72519854
46Prominent metopic ridge (HP:0005487)2.71468640
47Menstrual irregularities (HP:0000858)2.70807194
48Gaze-evoked nystagmus (HP:0000640)2.70784934
49Inability to walk (HP:0002540)2.66852182
50Hypomagnesemia (HP:0002917)2.66830578
51Insulin resistance (HP:0000855)2.65716942
52Medial flaring of the eyebrow (HP:0010747)2.64957760
53Congenital sensorineural hearing impairment (HP:0008527)2.64503553
54Hyperkalemia (HP:0002153)2.64452020
55Recurrent gram-negative bacterial infections (HP:0005420)2.59002845
56Abnormality of chloride homeostasis (HP:0011422)2.53589968
57Hypothermia (HP:0002045)2.50112298
58Tubular atrophy (HP:0000092)2.49972223
59Basal ganglia calcification (HP:0002135)2.49825208
60Tinnitus (HP:0000360)2.48184793
61Mucopolysacchariduria (HP:0008155)2.47684135
62Urinary glycosaminoglycan excretion (HP:0003541)2.47684135
63Decreased electroretinogram (ERG) amplitude (HP:0000654)2.47291790
64Ketosis (HP:0001946)2.45679405
65Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.43731834
66Generalized aminoaciduria (HP:0002909)2.42684882
67Genetic anticipation (HP:0003743)2.42363597
68Neuroendocrine neoplasm (HP:0100634)2.41302567
69Abnormality of macular pigmentation (HP:0008002)2.40758502
70Dysautonomia (HP:0002459)2.40236356
71Osteomalacia (HP:0002749)2.39300542
72Increased neuronal autofluorescent lipopigment (HP:0002074)2.39028607
73Keratoconus (HP:0000563)2.37806329
74Increased corneal curvature (HP:0100692)2.37806329
75Cystic liver disease (HP:0006706)2.36282086
76Progressive inability to walk (HP:0002505)2.35070940
77Decreased central vision (HP:0007663)2.33644133
78Chronic otitis media (HP:0000389)2.33332814
79Pheochromocytoma (HP:0002666)2.30855079
80Elevated erythrocyte sedimentation rate (HP:0003565)2.29128190
81Agitation (HP:0000713)2.25255372
82Increased cerebral lipofuscin (HP:0011813)2.24052427
83Polyuria (HP:0000103)2.21707700
84Methylmalonic acidemia (HP:0002912)2.19400599
85Chronic hepatic failure (HP:0100626)2.18735835
86Chorioretinal atrophy (HP:0000533)2.18647847
87Adrenal overactivity (HP:0002717)2.17994761
88Renal cortical cysts (HP:0000803)2.17041394
89Systemic lupus erythematosus (HP:0002725)2.16865204
90Abnormality of renin-angiotensin system (HP:0000847)2.15173681
91Birth length less than 3rd percentile (HP:0003561)2.14950540
92Abnormality of mucopolysaccharide metabolism (HP:0011020)2.14719000
93Abnormality of polysaccharide metabolism (HP:0011012)2.14719000
94Abnormality of glycosaminoglycan metabolism (HP:0004371)2.14719000
95Abnormality of the metopic suture (HP:0005556)2.14079896
96Dialeptic seizures (HP:0011146)2.12415442
97Tetraparesis (HP:0002273)2.12374366
98Pathologic fracture (HP:0002756)2.12069354
99Broad-based gait (HP:0002136)2.11515778
100Gingivitis (HP:0000230)2.11444965
101Abnormal pancreas size (HP:0012094)2.10563576
102Abnormality of alanine metabolism (HP:0010916)2.09814401
103Hyperalaninemia (HP:0003348)2.09814401
104Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.09814401
105Exocrine pancreatic insufficiency (HP:0001738)2.09326087
106Hemiparesis (HP:0001269)2.09063394
107Periodontitis (HP:0000704)2.06915751
108Joint swelling (HP:0001386)2.05045533
109Abnormality of proline metabolism (HP:0010907)2.04962826
110Hydroxyprolinuria (HP:0003080)2.04962826
111Nasal polyposis (HP:0100582)2.04934637
112Hypergammaglobulinemia (HP:0010702)2.04673981
113Abnormality of potassium homeostasis (HP:0011042)2.03935572
114Focal seizures (HP:0007359)2.03823772
115Abnormal respiratory motile cilium morphology (HP:0005938)2.03198906
116Abnormal respiratory epithelium morphology (HP:0012253)2.03198906
117Hypotension (HP:0002615)2.02444591
118Absent speech (HP:0001344)2.01987929
119Fair hair (HP:0002286)2.01581481
120Tachypnea (HP:0002789)2.01440076
121Severe visual impairment (HP:0001141)2.01048715
122Hypokalemia (HP:0002900)2.00675051
123Gastrointestinal infarctions (HP:0005244)1.99713270
124Gait imbalance (HP:0002141)1.98378351
125Abdominal distention (HP:0003270)1.98209483
126Conjugated hyperbilirubinemia (HP:0002908)1.98070508
127Disproportionate short-trunk short stature (HP:0003521)1.97868338
128Hyperactive renin-angiotensin system (HP:0000841)1.97788828
129Mitochondrial inheritance (HP:0001427)1.97320931
130Hepatic necrosis (HP:0002605)1.96608758
131Increased CSF lactate (HP:0002490)1.96500976
132Congenital hepatic fibrosis (HP:0002612)1.96190526
133Abnormality of glycolipid metabolism (HP:0010969)1.95951114
134Abnormality of liposaccharide metabolism (HP:0010968)1.95951114
135Abnormality of glycosphingolipid metabolism (HP:0004343)1.95951114
136Orthostatic hypotension (HP:0001278)1.95832268
137Polygenic inheritance (HP:0010982)1.95457001
138Protruding tongue (HP:0010808)1.95454131
139Abnormality of magnesium homeostasis (HP:0004921)1.94968505
140Hypophosphatemia (HP:0002148)1.94890533
141Focal motor seizures (HP:0011153)1.93445406
142Sclerocornea (HP:0000647)1.93202181
143Bile duct proliferation (HP:0001408)1.92954261
144Abnormal biliary tract physiology (HP:0012439)1.92954261
145Congenital primary aphakia (HP:0007707)1.91977276
146Lissencephaly (HP:0001339)1.91952243
147Progressive macrocephaly (HP:0004481)1.91800850
148Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.91764727
149Furrowed tongue (HP:0000221)1.90200783
150Absent rod-and cone-mediated responses on ERG (HP:0007688)1.87524243
151Febrile seizures (HP:0002373)1.87263072
152Absent/shortened dynein arms (HP:0200106)1.87042869
153Dynein arm defect of respiratory motile cilia (HP:0012255)1.87042869
154Decreased circulating renin level (HP:0003351)1.86498576
155Bony spicule pigmentary retinopathy (HP:0007737)1.86240142
156Progressive visual loss (HP:0000529)1.86192521
157Clumsiness (HP:0002312)1.85108575
158Neoplasm of the adrenal cortex (HP:0100641)1.84970850
159Increased CSF protein (HP:0002922)1.84918201
160Cerebral hemorrhage (HP:0001342)1.84877174
161Pigmentary retinal degeneration (HP:0001146)1.83290428
162Acute necrotizing encephalopathy (HP:0006965)1.83235442
163Oligomenorrhea (HP:0000876)1.82662846
164Chronic bronchitis (HP:0004469)1.82546548
165Progressive neurologic deterioration (HP:0002344)1.82534443
166Stomach cancer (HP:0012126)1.81306192
167Congenital, generalized hypertrichosis (HP:0004540)1.80917352
168Cardiomegaly (HP:0001640)1.80659372
169Abnormality of purine metabolism (HP:0004352)1.79793652
170Optic disc pallor (HP:0000543)1.79171078
171Abnormal urine output (HP:0012590)1.79062635
172Unilateral renal agenesis (HP:0000122)1.78396164
173Intestinal atresia (HP:0011100)1.78229477
174Hand muscle atrophy (HP:0009130)1.78083095
175Chronic sinusitis (HP:0011109)1.77056504
176Abnormality of the fovea (HP:0000493)1.77004085
177Nephrogenic diabetes insipidus (HP:0009806)1.76302088
178Methylmalonic aciduria (HP:0012120)1.76105253
179Retinitis pigmentosa (HP:0000510)1.76088274
180Abnormality of fatty-acid metabolism (HP:0004359)1.75822202
181Pachygyria (HP:0001302)1.75806041
182Abnormal ciliary motility (HP:0012262)1.75712813
183Metabolic alkalosis (HP:0200114)1.74796670
184Recurrent bacterial skin infections (HP:0005406)1.74440386
185Constricted visual fields (HP:0001133)1.73426447
186Hepatocellular necrosis (HP:0001404)1.73278958
187Polycythemia (HP:0001901)1.73277023
188Vasculitis (HP:0002633)1.73175713
189Aplasia/Hypoplasia of the fovea (HP:0008060)1.72981905

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK156.77020439
2WNK36.19997627
3PIK3CG3.55128410
4ACVR1B3.54798539
5WNK43.07043680
6INSRR2.82849358
7MAP4K22.79742265
8MAP3K142.74245099
9CASK2.67069471
10EPHA32.32448402
11FRK2.31570394
12MAP3K22.22480412
13OXSR12.21078246
14PINK12.20976235
15BLK2.15195056
16ZAK2.01610472
17ERN11.91759033
18EPHA21.83892220
19PIM21.72707954
20CDK191.72357783
21MAP3K41.70574401
22TYK21.62061982
23PASK1.61908150
24ARAF1.59524393
25TXK1.59278466
26STK38L1.57786884
27MAPK131.55094458
28EPHB11.51491690
29FGFR41.49225377
30MAP3K131.48794687
31TRIM281.46545449
32DYRK1B1.45763859
33TESK11.45588542
34TNIK1.39672572
35TAOK31.38223918
36TBK11.35034051
37HIPK21.29748527
38FGFR21.29669120
39STK391.29354387
40JAK31.27067226
41CHUK1.24877219
42JAK11.24033028
43NTRK31.23763154
44IKBKB1.23245282
45TGFBR11.23010859
46BMPR21.20615074
47ADRBK11.20547088
48NEK91.18658992
49BCR1.18443899
50FLT31.18126677
51PTK61.12077333
52MKNK21.09618406
53ERBB31.07965866
54FER1.06038584
55MST1R1.04888059
56WNK11.03418508
57CSK1.01462359
58MAP2K21.00110615
59UHMK10.99887041
60MAP2K60.97577729
61BMPR1B0.97124279
62IRAK10.96747786
63KSR20.96334166
64PHKG10.96081996
65PHKG20.96081996
66PIK3CA0.95900590
67TLK10.95482838
68PRKCG0.95362604
69SIK10.94270989
70ZAP700.93320193
71MAP2K70.92086613
72MAP3K10.90884742
73PTK20.88128858
74MARK10.87793941
75CSNK1G10.86179680
76LMTK20.84463160
77IKBKE0.83886891
78PLK20.82104513
79CSNK1G20.81033176
80IRAK30.80790025
81PAK30.77651684
82TRIB30.75460370
83CSNK1G30.75348180
84MST40.74876240
85STK30.73009890
86ADRBK20.72985187
87JAK20.72195099
88NUAK10.72172008
89DYRK20.71068743
90NLK0.70278602
91PTK2B0.69530571
92MAP3K30.68541993
93GRK70.67238317
94IRAK40.66094900
95NTRK20.65681595
96PRKAA20.64759613
97TIE10.64417629
98PRKCQ0.63992637
99TNK20.63191879
100BRAF0.62136594
101MAP3K120.59992320
102CAMK2A0.59489441
103BCKDK0.59417764
104PNCK0.59209372
105STK110.59193000
106RIPK40.58215750
107FGFR30.58068989
108TEC0.56818347
109MAP2K10.56036661
110BRSK20.55958264
111VRK10.55601923
112CSNK1A1L0.55527310
113NME10.55514132
114NTRK10.50955456
115CSNK1A10.50788186
116PRKACA0.50095958
117ABL20.49242959
118CAMKK20.48557758
119MAPKAPK20.47734927
120PRKCI0.46328257
121RIPK10.45638690
122PRKG10.44230840
123ITK0.43441764
124MAP4K10.43279126
125PRKCA0.42192177
126CAMK10.42121368
127LRRK20.42078263
128PRKCE0.41415498
129DAPK20.41274174
130BTK0.41101722
131PBK0.41034701
132SCYL20.40584921
133MKNK10.40397903
134PLK30.39744523
135LIMK10.39700818
136PRKAA10.38384456
137RET0.37818786
138CAMK2D0.37044218
139GRK50.36797314
140CAMK1D0.36393246
141DAPK30.36242968
142PRKCZ0.35496411
143RPS6KA50.35412733
144MET0.35041468
145EIF2AK30.34555959
146EIF2AK20.34495731
147EPHA40.34471187
148MAPKAPK50.33267325
149STK160.32672281
150MAP3K70.32349177
151GRK10.31336100
152CDC42BPA0.30198814
153MUSK0.29488382
154PRKG20.29427324
155IGF1R0.29225399
156MAPKAPK30.29141527
157SYK0.28543027
158LYN0.28405929
159RPS6KA10.27276666
160SIK30.26796998
161DAPK10.26741124
162KIT0.26363225
163MOS0.26091556
164CSNK1D0.25997229
165TRPM70.25546093
166GSK3A0.23984152
167EPHB20.23632667
168ABL10.22034568

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049507.24310372
2Protein export_Homo sapiens_hsa030604.04312176
3Type I diabetes mellitus_Homo sapiens_hsa049403.43026381
4Butanoate metabolism_Homo sapiens_hsa006502.96707989
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.67439778
6Allograft rejection_Homo sapiens_hsa053302.63112021
7Nitrogen metabolism_Homo sapiens_hsa009102.58165851
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.49228680
9Phototransduction_Homo sapiens_hsa047442.47266280
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.15409675
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.08420782
12Graft-versus-host disease_Homo sapiens_hsa053322.01917817
13Vibrio cholerae infection_Homo sapiens_hsa051101.98366019
14Lysosome_Homo sapiens_hsa041421.88594871
15Caffeine metabolism_Homo sapiens_hsa002321.81233353
16Sulfur metabolism_Homo sapiens_hsa009201.80035746
17Oxidative phosphorylation_Homo sapiens_hsa001901.79068126
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.78929294
19Insulin secretion_Homo sapiens_hsa049111.78427950
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.77268531
21Nicotine addiction_Homo sapiens_hsa050331.76970216
22Autoimmune thyroid disease_Homo sapiens_hsa053201.75346037
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.74075226
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.67226991
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.62753172
26Type II diabetes mellitus_Homo sapiens_hsa049301.58382202
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.55351836
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53908544
29Folate biosynthesis_Homo sapiens_hsa007901.51805012
30Other glycan degradation_Homo sapiens_hsa005111.49337710
31Propanoate metabolism_Homo sapiens_hsa006401.46224741
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.41923437
33Selenocompound metabolism_Homo sapiens_hsa004501.41009600
34Legionellosis_Homo sapiens_hsa051341.40473759
35Pertussis_Homo sapiens_hsa051331.34091784
36Phenylalanine metabolism_Homo sapiens_hsa003601.32450164
37Carbohydrate digestion and absorption_Homo sapiens_hsa049731.28926040
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.27390817
39Antigen processing and presentation_Homo sapiens_hsa046121.26381801
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.22910015
41Rheumatoid arthritis_Homo sapiens_hsa053231.22340511
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.17824937
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16787489
44Olfactory transduction_Homo sapiens_hsa047401.15239494
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.14321620
46Retinol metabolism_Homo sapiens_hsa008301.14098326
47Glycosaminoglycan degradation_Homo sapiens_hsa005311.12484397
48ABC transporters_Homo sapiens_hsa020101.10557913
49Morphine addiction_Homo sapiens_hsa050321.10461269
50Taste transduction_Homo sapiens_hsa047421.09703155
51Chemical carcinogenesis_Homo sapiens_hsa052041.08805541
52SNARE interactions in vesicular transport_Homo sapiens_hsa041301.06195951
53Tryptophan metabolism_Homo sapiens_hsa003801.05846017
54Parkinsons disease_Homo sapiens_hsa050121.04780063
55RNA polymerase_Homo sapiens_hsa030201.01945140
56Leishmaniasis_Homo sapiens_hsa051401.01931545
57NF-kappa B signaling pathway_Homo sapiens_hsa040640.99083196
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.98995776
59Prolactin signaling pathway_Homo sapiens_hsa049170.98693092
60Ovarian steroidogenesis_Homo sapiens_hsa049130.98571427
61Basal transcription factors_Homo sapiens_hsa030220.98409918
62Toxoplasmosis_Homo sapiens_hsa051450.97847272
63Serotonergic synapse_Homo sapiens_hsa047260.97016362
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.95557883
65Influenza A_Homo sapiens_hsa051640.94463864
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92634051
67Apoptosis_Homo sapiens_hsa042100.92586837
68Measles_Homo sapiens_hsa051620.90740392
69Dorso-ventral axis formation_Homo sapiens_hsa043200.90330022
70TNF signaling pathway_Homo sapiens_hsa046680.88860818
71Prion diseases_Homo sapiens_hsa050200.88624152
72Fatty acid elongation_Homo sapiens_hsa000620.88302279
73Homologous recombination_Homo sapiens_hsa034400.87628690
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.86777445
75Glutamatergic synapse_Homo sapiens_hsa047240.86570317
76Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85986936
77Fatty acid biosynthesis_Homo sapiens_hsa000610.85436712
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84471048
79GABAergic synapse_Homo sapiens_hsa047270.83883064
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.83663305
81Fatty acid degradation_Homo sapiens_hsa000710.83630456
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82933562
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81590694
84Glycerolipid metabolism_Homo sapiens_hsa005610.81138528
85Circadian entrainment_Homo sapiens_hsa047130.80385015
86Circadian rhythm_Homo sapiens_hsa047100.79982038
87Phagosome_Homo sapiens_hsa041450.79652269
88Hepatitis C_Homo sapiens_hsa051600.78808326
89PPAR signaling pathway_Homo sapiens_hsa033200.78137079
90Salivary secretion_Homo sapiens_hsa049700.77062258
91Fanconi anemia pathway_Homo sapiens_hsa034600.74182551
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.72957191
93Mineral absorption_Homo sapiens_hsa049780.72827900
94Viral myocarditis_Homo sapiens_hsa054160.69946934
95Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69481525
96Chemokine signaling pathway_Homo sapiens_hsa040620.69468354
97Cardiac muscle contraction_Homo sapiens_hsa042600.69358005
98Osteoclast differentiation_Homo sapiens_hsa043800.69175798
99Tuberculosis_Homo sapiens_hsa051520.68913895
100Asthma_Homo sapiens_hsa053100.68534174
101Alzheimers disease_Homo sapiens_hsa050100.67983345
102Regulation of autophagy_Homo sapiens_hsa041400.67511890
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.66320622
104Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65513599
105Acute myeloid leukemia_Homo sapiens_hsa052210.64810870
106Tyrosine metabolism_Homo sapiens_hsa003500.63168307
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62628268
108Shigellosis_Homo sapiens_hsa051310.61228218
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60734951
110Insulin resistance_Homo sapiens_hsa049310.60529742
111N-Glycan biosynthesis_Homo sapiens_hsa005100.59309984
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59129479
113Metabolic pathways_Homo sapiens_hsa011000.57836059
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57513116
115Glucagon signaling pathway_Homo sapiens_hsa049220.55192845
116Huntingtons disease_Homo sapiens_hsa050160.54093164
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51890238
118Histidine metabolism_Homo sapiens_hsa003400.50867439
119RNA degradation_Homo sapiens_hsa030180.50461506
120Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50119431
121Thyroid cancer_Homo sapiens_hsa052160.50094645
122Collecting duct acid secretion_Homo sapiens_hsa049660.49981071
123Calcium signaling pathway_Homo sapiens_hsa040200.48921993
124Herpes simplex infection_Homo sapiens_hsa051680.46727148
125Dopaminergic synapse_Homo sapiens_hsa047280.45520280
126Synaptic vesicle cycle_Homo sapiens_hsa047210.45446417
127Malaria_Homo sapiens_hsa051440.44160090
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43491517
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.43349357
130Cocaine addiction_Homo sapiens_hsa050300.43241237
131Purine metabolism_Homo sapiens_hsa002300.43076897
132Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42805256
133Peroxisome_Homo sapiens_hsa041460.42613352
134Fatty acid metabolism_Homo sapiens_hsa012120.42068661
135Renin secretion_Homo sapiens_hsa049240.41999431
136Leukocyte transendothelial migration_Homo sapiens_hsa046700.41279380
137Long-term depression_Homo sapiens_hsa047300.41063979
138Sphingolipid metabolism_Homo sapiens_hsa006000.40697369
139Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40317634
140African trypanosomiasis_Homo sapiens_hsa051430.40089588
141Salmonella infection_Homo sapiens_hsa051320.39920528
142Amphetamine addiction_Homo sapiens_hsa050310.39700053
143Thyroid hormone synthesis_Homo sapiens_hsa049180.38809604
144Amoebiasis_Homo sapiens_hsa051460.38666802
145Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38293770
146Gastric acid secretion_Homo sapiens_hsa049710.37673901
147Vascular smooth muscle contraction_Homo sapiens_hsa042700.33743207
148alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32479602
149Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32141480
150Bladder cancer_Homo sapiens_hsa052190.31607918
151Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.31346071
152Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.30416459
153Pancreatic secretion_Homo sapiens_hsa049720.29454866
154Starch and sucrose metabolism_Homo sapiens_hsa005000.29344209
155Galactose metabolism_Homo sapiens_hsa000520.28680868
156Linoleic acid metabolism_Homo sapiens_hsa005910.28597990
157Inositol phosphate metabolism_Homo sapiens_hsa005620.27570965
158Ether lipid metabolism_Homo sapiens_hsa005650.26987683
159Insulin signaling pathway_Homo sapiens_hsa049100.26789972
160beta-Alanine metabolism_Homo sapiens_hsa004100.26254061
161Arachidonic acid metabolism_Homo sapiens_hsa005900.25438545
162Fat digestion and absorption_Homo sapiens_hsa049750.24695843
163Hepatitis B_Homo sapiens_hsa051610.24488147
164Estrogen signaling pathway_Homo sapiens_hsa049150.23247086

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