FGA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the alpha subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Following vascular injury, the encoded preproprotein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.53164759
2L-phenylalanine catabolic process (GO:0006559)7.53164759
3exogenous drug catabolic process (GO:0042738)7.23736472
4L-phenylalanine metabolic process (GO:0006558)7.19524668
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.19524668
6epoxygenase P450 pathway (GO:0019373)6.90074834
7aromatic amino acid family catabolic process (GO:0009074)6.73019843
8omega-hydroxylase P450 pathway (GO:0097267)6.67171218
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.44417164
10tryptophan catabolic process (GO:0006569)6.09740466
11indole-containing compound catabolic process (GO:0042436)6.09740466
12indolalkylamine catabolic process (GO:0046218)6.09740466
13kynurenine metabolic process (GO:0070189)5.98779125
14negative regulation of fibrinolysis (GO:0051918)5.93839037
15bile acid biosynthetic process (GO:0006699)5.88072408
16glyoxylate metabolic process (GO:0046487)5.84817282
17tryptophan metabolic process (GO:0006568)5.73903680
18regulation of fibrinolysis (GO:0051917)5.72650309
19urea cycle (GO:0000050)5.70940143
20urea metabolic process (GO:0019627)5.70940143
21complement activation, alternative pathway (GO:0006957)5.68753022
22high-density lipoprotein particle remodeling (GO:0034375)5.65825108
23* regulation of protein activation cascade (GO:2000257)5.57988979
24alpha-linolenic acid metabolic process (GO:0036109)5.55431687
25peptidyl-glutamic acid carboxylation (GO:0017187)5.55098127
26protein carboxylation (GO:0018214)5.55098127
27* positive regulation of heterotypic cell-cell adhesion (GO:0034116)5.52684451
28uronic acid metabolic process (GO:0006063)5.48243616
29regulation of complement activation (GO:0030449)5.36951240
30cysteine metabolic process (GO:0006534)5.26854322
31regulation of humoral immune response (GO:0002920)5.24693931
32nitrogen cycle metabolic process (GO:0071941)5.23905976
33sulfur amino acid catabolic process (GO:0000098)5.19482094
34serine family amino acid catabolic process (GO:0009071)5.06201057
35reverse cholesterol transport (GO:0043691)5.02614775
36bile acid metabolic process (GO:0008206)5.02607342
37intestinal cholesterol absorption (GO:0030299)4.98381599
38regulation of cholesterol esterification (GO:0010872)4.96363543
39regulation of triglyceride catabolic process (GO:0010896)4.94549555
40macromolecular complex remodeling (GO:0034367)4.91903815
41plasma lipoprotein particle remodeling (GO:0034369)4.91903815
42protein-lipid complex remodeling (GO:0034368)4.91903815
43fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.91741057
44aromatic amino acid family metabolic process (GO:0009072)4.88399760
45drug metabolic process (GO:0017144)4.83641158
46tyrosine metabolic process (GO:0006570)4.75615910
47phospholipid efflux (GO:0033700)4.70162723
48homocysteine metabolic process (GO:0050667)4.70140565
49acylglycerol homeostasis (GO:0055090)4.69627207
50triglyceride homeostasis (GO:0070328)4.69627207
51alpha-amino acid catabolic process (GO:1901606)4.57780310
52lysine metabolic process (GO:0006553)4.55644141
53lysine catabolic process (GO:0006554)4.55644141
54amino-acid betaine metabolic process (GO:0006577)4.52780470
55negative regulation of sterol transport (GO:0032372)4.51114903
56negative regulation of cholesterol transport (GO:0032375)4.51114903
57plasma lipoprotein particle clearance (GO:0034381)4.48218950
58regulation of apoptotic cell clearance (GO:2000425)4.46456782
59oxidative demethylation (GO:0070989)4.39551458
60glycine metabolic process (GO:0006544)4.36191692
61cholesterol efflux (GO:0033344)4.36103325
62coenzyme catabolic process (GO:0009109)4.34604253
63bile acid and bile salt transport (GO:0015721)4.34378256
64cellular ketone body metabolic process (GO:0046950)4.33374925
65indolalkylamine metabolic process (GO:0006586)4.31294052
66* negative regulation of hemostasis (GO:1900047)4.30827702
67* negative regulation of blood coagulation (GO:0030195)4.30827702
68imidazole-containing compound metabolic process (GO:0052803)4.30789322
69killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.30546950
70disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.30546950
71protein-lipid complex subunit organization (GO:0071825)4.23775676
72glutamate metabolic process (GO:0006536)4.23222682
73fibrinolysis (GO:0042730)4.22110807
74amine catabolic process (GO:0009310)4.20214540
75cellular biogenic amine catabolic process (GO:0042402)4.20214540
76ethanol metabolic process (GO:0006067)4.19549435
77cellular amino acid catabolic process (GO:0009063)4.19078567
78plasma lipoprotein particle assembly (GO:0034377)4.15579672
79serine family amino acid metabolic process (GO:0009069)4.12481278
80positive regulation of blood coagulation (GO:0030194)4.07466046
81positive regulation of hemostasis (GO:1900048)4.07466046
82blood coagulation, intrinsic pathway (GO:0007597)4.07295997
83acute-phase response (GO:0006953)4.07250831
84benzene-containing compound metabolic process (GO:0042537)4.06421490
85dicarboxylic acid biosynthetic process (GO:0043650)4.05363914
86low-density lipoprotein particle remodeling (GO:0034374)4.05176547
87cellular glucuronidation (GO:0052695)4.04376579
88cellular modified amino acid catabolic process (GO:0042219)4.02556834
89arginine metabolic process (GO:0006525)3.99780602
90complement activation, classical pathway (GO:0006958)3.99133224
91serine family amino acid biosynthetic process (GO:0009070)3.98698354
92negative regulation of complement activation (GO:0045916)3.98348305
93* negative regulation of protein activation cascade (GO:2000258)3.98348305
94aldehyde catabolic process (GO:0046185)3.94758299
95* negative regulation of coagulation (GO:0050819)3.93195686
96complement activation (GO:0006956)3.93162183
97positive regulation of lipoprotein lipase activity (GO:0051006)3.92058663
98positive regulation of triglyceride lipase activity (GO:0061365)3.92058663
99* negative regulation of wound healing (GO:0061045)3.91803215
100ethanol oxidation (GO:0006069)3.91751512
101opsonization (GO:0008228)3.85512551
102very-low-density lipoprotein particle assembly (GO:0034379)3.84402214
103* protein activation cascade (GO:0072376)3.83983981
104phospholipid homeostasis (GO:0055091)3.83757723
105acute inflammatory response (GO:0002526)3.82942452
106cofactor catabolic process (GO:0051187)3.80877055
107positive regulation of lipid catabolic process (GO:0050996)3.79769708
108drug catabolic process (GO:0042737)3.79767062
109cholesterol homeostasis (GO:0042632)3.76819609
110cytolysis (GO:0019835)3.76617752
111plasma lipoprotein particle organization (GO:0071827)3.76229801
112positive regulation of coagulation (GO:0050820)3.76225815
113ketone body metabolic process (GO:1902224)3.74809744
114negative regulation of lipase activity (GO:0060192)3.74654325
115regulation of cholesterol homeostasis (GO:2000188)3.73973082
116heme transport (GO:0015886)3.72760479
117protein-lipid complex assembly (GO:0065005)3.72038211
118phenylpropanoid metabolic process (GO:0009698)3.71284187
119flavonoid metabolic process (GO:0009812)3.70849201
120sterol homeostasis (GO:0055092)3.70623545
121regulation of bile acid biosynthetic process (GO:0070857)3.66445828
122carboxylic acid catabolic process (GO:0046395)3.65376186
123organic acid catabolic process (GO:0016054)3.65376186
124positive regulation of fatty acid biosynthetic process (GO:0045723)3.62336237
125regulation of plasminogen activation (GO:0010755)3.61456481
126lipoprotein metabolic process (GO:0042157)3.61128415
127acetyl-CoA metabolic process (GO:0006084)3.60990794
128doxorubicin metabolic process (GO:0044598)3.60651100
129daunorubicin metabolic process (GO:0044597)3.60651100
130polyketide metabolic process (GO:0030638)3.60651100
131glucuronate metabolic process (GO:0019585)3.57799281
132regulation of acute inflammatory response (GO:0002673)3.52453085
133sterol transport (GO:0015918)3.48526117
134cholesterol transport (GO:0030301)3.48526117

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.31565171
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.13871139
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.02361695
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.46474356
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.30182623
6* CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.19431167
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.79439619
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.15082267
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.13342799
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.03909093
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.1314380
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.97921187
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91842041
14* FOXA2_19822575_ChIP-Seq_HepG2_Human1.62828316
15CLOCK_20551151_ChIP-Seq_293T_Human1.56952804
16HTT_18923047_ChIP-ChIP_STHdh_Human1.52995987
17GATA1_22025678_ChIP-Seq_K562_Human1.51588314
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.43371751
19* HNF4A_19822575_ChIP-Seq_HepG2_Human1.40714667
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.30041445
21TRIM28_21343339_ChIP-Seq_HEK293_Human1.24124688
22ESR1_15608294_ChIP-ChIP_MCF-7_Human1.20907809
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.20219528
24RXRA_24833708_ChIP-Seq_LIVER_Mouse1.19027396
25PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.07321497
26TCF4_18268006_ChIP-ChIP_LS174T_Human1.06123812
27CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.04695386
28FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02332111
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01798347
30ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97043404
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.95317419
32IRF8_22096565_ChIP-ChIP_GC-B_Human0.93310496
33SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90859870
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90186703
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87359588
36AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82908778
37RARG_19884340_ChIP-ChIP_MEFs_Mouse0.81934009
38PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.80502019
39BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79712160
40ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.79350838
41GATA4_25053715_ChIP-Seq_YYC3_Human0.77483849
42SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75878320
43NFE2_27457419_Chip-Seq_LIVER_Mouse0.73082882
44ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.72987992
45SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.72705121
46RARA_24833708_ChIP-Seq_LIVER_Mouse0.72637248
47CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.72163593
48Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.71009403
49KAP1_22055183_ChIP-Seq_ESCs_Mouse0.70582480
50ZNF263_19887448_ChIP-Seq_K562_Human0.69845711
51SALL4_18804426_ChIP-ChIP_XEN_Mouse0.69771263
52RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.68990740
53AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.68333501
54CDX2_19796622_ChIP-Seq_MESCs_Mouse0.67951123
55ESR2_21235772_ChIP-Seq_MCF-7_Human0.67364855
56AR_21909140_ChIP-Seq_LNCAP_Human0.66003119
57NRF2_20460467_ChIP-Seq_MEFs_Mouse0.63165733
58NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.63165733
59ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.62531314
60RARB_24833708_ChIP-Seq_LIVER_Mouse0.61323449
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.60723477
62SMAD1_18555785_Chip-Seq_ESCs_Mouse0.60004400
63PCGF2_27294783_Chip-Seq_NPCs_Mouse0.59064020
64RAD21_21589869_ChIP-Seq_MESCs_Mouse0.58997156
65BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.57364780
66NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.57264278
67FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.56991463
68SUZ12_27294783_Chip-Seq_NPCs_Mouse0.56088560
69STAT3_1855785_ChIP-Seq_MESCs_Mouse0.56061451
70OCT4_18555785_Chip-Seq_ESCs_Mouse0.55975931
71CEBPB_22108803_ChIP-Seq_LS180_Human0.55740737
72EZH2_27294783_Chip-Seq_NPCs_Mouse0.54987567
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.54909970
74TP53_18474530_ChIP-ChIP_U2OS_Human0.54777531
75POU5F1_16518401_ChIP-PET_MESCs_Mouse0.54706774
76EGR1_19032775_ChIP-ChIP_M12_Human0.53412727
77FOXA1_25552417_ChIP-Seq_VCAP_Human0.53052641
78LXR_22292898_ChIP-Seq_THP-1_Human0.52668929
79FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.51485848
80ESRRB_18555785_Chip-Seq_ESCs_Mouse0.51412805
81FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50952415
82TP53_16413492_ChIP-PET_HCT116_Human0.50823784
83GATA3_24758297_ChIP-Seq_MCF-7_Human0.50511106
84SOX2_21211035_ChIP-Seq_LN229_Human0.50364558
85CTNNB1_20460455_ChIP-Seq_HCT116_Human0.50264314
86RUNX1_27457419_Chip-Seq_LIVER_Mouse0.49928871
87MYC_19915707_ChIP-ChIP_AK7_Human0.49768637
88PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.49757323
89HNFA_21074721_ChIP-Seq_CACO-2_Human0.49352119
90NFIB_24661679_ChIP-Seq_LUNG_Mouse0.49230857
91* AR_20517297_ChIP-Seq_VCAP_Human0.48650033
92ESR1_21235772_ChIP-Seq_MCF-7_Human0.48187329
93PIAS1_25552417_ChIP-Seq_VCAP_Human0.47853324
94CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.46782070
95CBP_21632823_ChIP-Seq_H3396_Human0.46764413
96CBX2_22325352_ChIP-Seq_293T-Rex_Human0.46161244
97CDX2_20551321_ChIP-Seq_CACO-2_Human0.45788719
98GATA1_19941826_ChIP-Seq_K562_Human0.45615686
99P53_21459846_ChIP-Seq_SAOS-2_Human0.45246829
100ZFX_18555785_Chip-Seq_ESCs_Mouse0.45021518
101ESET_19884257_ChIP-Seq_ESCs_Mouse0.44985979
102RAC3_21632823_ChIP-Seq_H3396_Human0.44613058
103PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.44258679
104KLF4_18555785_Chip-Seq_ESCs_Mouse0.43947861
105PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.43823434
106FOXO3_23340844_ChIP-Seq_DLD1_Human0.43761503
107STAT1_17558387_ChIP-Seq_HELA_Human0.42590739
108TAF2_19829295_ChIP-Seq_ESCs_Human0.42370270
109FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.42295732
110ESR1_20079471_ChIP-ChIP_T-47D_Human0.41762815
111GATA2_19941826_ChIP-Seq_K562_Human0.41559769
112GATA1_19941827_ChIP-Seq_MEL_Mouse0.41284252
113TAF15_26573619_Chip-Seq_HEK293_Human0.41196145
114SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40248418
115GATA6_25053715_ChIP-Seq_YYC3_Human0.39952978
116PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.39722226
117PPAR_26484153_Chip-Seq_NCI-H1993_Human0.38646939
118E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.38350033
119IRF1_19129219_ChIP-ChIP_H3396_Human0.38257116
120BCAT_22108803_ChIP-Seq_LS180_Human0.37761667
121CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.37245471
122* MYC_27129775_Chip-Seq_CORNEA_Mouse0.36045222
123GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.35337227
124ERG_21242973_ChIP-ChIP_JURKAT_Human0.35313395
125* STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.34205858
126SOX2_20726797_ChIP-Seq_SW620_Human0.33698625
127SPI1_26923725_Chip-Seq_HPCs_Mouse0.33347925
128ERG_20517297_ChIP-Seq_VCAP_Human0.33268076
129CDX2_22108803_ChIP-Seq_LS180_Human0.32899736
130CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.32842421
131SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.32437949

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.16011589
2MP0005360_urolithiasis7.49758653
3MP0005085_abnormal_gallbladder_physiolo6.42538986
4MP0005365_abnormal_bile_salt6.11302373
5MP0008875_abnormal_xenobiotic_pharmacok4.96456999
6MP0003806_abnormal_nucleotide_metabolis4.24012919
7MP0003252_abnormal_bile_duct3.88627315
8MP0010329_abnormal_lipoprotein_level3.64521118
9MP0009840_abnormal_foam_cell3.32641008
10MP0005083_abnormal_biliary_tract3.19850582
11MP0003195_calcinosis2.83713399
12MP0005332_abnormal_amino_acid2.73478191
13MP0003191_abnormal_cellular_cholesterol2.66435208
14MP0001666_abnormal_nutrient_absorption2.59136554
15MP0000609_abnormal_liver_physiology2.21053710
16MP0004019_abnormal_vitamin_homeostasis2.12185049
17MP0002118_abnormal_lipid_homeostasis2.10801840
18MP0002138_abnormal_hepatobiliary_system2.00780756
19MP0003868_abnormal_feces_composition1.85582337
20MP0005319_abnormal_enzyme/_coenzyme1.82623755
21MP0001764_abnormal_homeostasis1.62668330
22MP0009697_abnormal_copulation1.59254894
23MP0005584_abnormal_enzyme/coenzyme_acti1.57133509
24MP0003011_delayed_dark_adaptation1.48757578
25MP0003656_abnormal_erythrocyte_physiolo1.32620510
26MP0005451_abnormal_body_composition1.32488026
27MP0001915_intracranial_hemorrhage1.24835054
28MP0009643_abnormal_urine_homeostasis1.23272748
29MP0003122_maternal_imprinting1.22266096
30MP0000604_amyloidosis1.21592658
31MP0003186_abnormal_redox_activity1.21450564
32MP0003705_abnormal_hypodermis_morpholog1.21097619
33* MP0000598_abnormal_liver_morphology1.18131879
34MP0002254_reproductive_system_inflammat1.14803760
35MP0005647_abnormal_sex_gland1.14459472
36MP0009764_decreased_sensitivity_to1.11317787
37MP0010368_abnormal_lymphatic_system1.10079260
38MP0009763_increased_sensitivity_to1.08855325
39MP0005636_abnormal_mineral_homeostasis0.97633014
40MP0005058_abnormal_lysosome_morphology0.97118798
41* MP0008469_abnormal_protein_level0.90922652
42* MP0009642_abnormal_blood_homeostasis0.88447719
43MP0000566_synostosis0.86731727
44MP0005670_abnormal_white_adipose0.86450596
45MP0004272_abnormal_basement_membrane0.85787487
46MP0005408_hypopigmentation0.83458157
47MP0002089_abnormal_postnatal_growth/wei0.82041066
48MP0009765_abnormal_xenobiotic_induced0.81275474
49MP0005084_abnormal_gallbladder_morpholo0.80921745
50MP0005376_homeostasis/metabolism_phenot0.79579344
51MP0005220_abnormal_exocrine_pancreas0.79504280
52MP0002078_abnormal_glucose_homeostasis0.77479676
53MP0006036_abnormal_mitochondrial_physio0.77278612
54MP0002971_abnormal_brown_adipose0.75634602
55MP0001661_extended_life_span0.73003985
56MP0002282_abnormal_trachea_morphology0.72687005
57MP0002876_abnormal_thyroid_physiology0.71446122
58MP0003690_abnormal_glial_cell0.71335775
59MP0009053_abnormal_anal_canal0.68959599
60MP0005334_abnormal_fat_pad0.68813349
61MP0003879_abnormal_hair_cell0.67287266
62MP0004130_abnormal_muscle_cell0.66233667
63MP0005535_abnormal_body_temperature0.66055304
64MP0000639_abnormal_adrenal_gland0.63299099
65MP0003329_amyloid_beta_deposits0.62852204
66MP0005266_abnormal_metabolism0.62212253
67MP0001756_abnormal_urination0.58103312
68MP0003123_paternal_imprinting0.56352077
69MP0005448_abnormal_energy_balance0.55341877
70MP0006035_abnormal_mitochondrial_morpho0.55190591
71MP0005395_other_phenotype0.53564722
72MP0005409_darkened_coat_color0.52807595
73MP0003436_decreased_susceptibility_to0.52605912
74MP0003724_increased_susceptibility_to0.51624362
75MP0005187_abnormal_penis_morphology0.51494788
76* MP0005464_abnormal_platelet_physiology0.49015288
77MP0002136_abnormal_kidney_physiology0.47359659
78MP0003632_abnormal_nervous_system0.46808186
79MP0002928_abnormal_bile_duct0.46706968
80MP0003638_abnormal_response/metabolism_0.46244747
81MP0008873_increased_physiological_sensi0.45378720
82MP0003718_maternal_effect0.44778704
83MP0000579_abnormal_nail_morphology0.44415862
84MP0009384_cardiac_valve_regurgitation0.43820745
85MP0003075_altered_response_to0.43648260
86MP0008874_decreased_physiological_sensi0.43443018
87MP0003941_abnormal_skin_development0.43241909
88MP0002822_catalepsy0.43019676
89MP0005166_decreased_susceptibility_to0.42904239
90MP0003172_abnormal_lysosome_physiology0.42397172
91MP0003953_abnormal_hormone_level0.40053693
92MP0005666_abnormal_adipose_tissue0.38531721
93MP0002249_abnormal_larynx_morphology0.38421240
94MP0002837_dystrophic_cardiac_calcinosis0.37741096
95MP0005248_abnormal_Harderian_gland0.37727263
96MP0004782_abnormal_surfactant_physiolog0.37462815
97MP0004381_abnormal_hair_follicle0.36545632
98MP0001986_abnormal_taste_sensitivity0.36454090
99MP0009780_abnormal_chondrocyte_physiolo0.35290171
100MP0002796_impaired_skin_barrier0.34657812
101MP0004883_abnormal_blood_vessel0.34238722
102MP0000249_abnormal_blood_vessel0.34115726
103* MP0005023_abnormal_wound_healing0.34017306
104MP0008872_abnormal_physiological_respon0.33187410
105MP0002168_other_aberrant_phenotype0.32891476
106MP0009115_abnormal_fat_cell0.32804524
107MP0009672_abnormal_birth_weight0.32791521
108MP0006082_CNS_inflammation0.32074882
109MP0001881_abnormal_mammary_gland0.31849748
110MP0006054_spinal_hemorrhage0.31708742
111MP0001243_abnormal_dermal_layer0.31361154
112MP0002970_abnormal_white_adipose0.31316475
113MP0001845_abnormal_inflammatory_respons0.30988007
114MP0004264_abnormal_extraembryonic_tissu0.30797294
115MP0005164_abnormal_response_to0.29893190
116MP0001853_heart_inflammation0.29695071
117MP0000230_abnormal_systemic_arterial0.29402824
118* MP0002128_abnormal_blood_circulation0.28712309
119MP0000371_diluted_coat_color0.28520951
120MP0005167_abnormal_blood-brain_barrier0.28152876
121MP0002132_abnormal_respiratory_system0.27849537
122MP0001324_abnormal_eye_pigmentation0.27580240
123MP0000427_abnormal_hair_cycle0.27580200
124MP0002909_abnormal_adrenal_gland0.27529177
125MP0002135_abnormal_kidney_morphology0.27388194
126MP0009785_altered_susceptibility_to0.25887349
127MP0000467_abnormal_esophagus_morphology0.25730078
128MP0003566_abnormal_cell_adhesion0.25441416
129MP0000858_altered_metastatic_potential0.24697367
130MP0002697_abnormal_eye_size0.22905447

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.58130445
2Intrahepatic cholestasis (HP:0001406)7.29410009
3Abnormality of aromatic amino acid family metabolism (HP:0004338)7.26867281
4Prolonged partial thromboplastin time (HP:0003645)6.85348213
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.64392875
6Hypobetalipoproteinemia (HP:0003563)6.43461049
7Xanthomatosis (HP:0000991)6.32696355
8Complement deficiency (HP:0004431)5.84905431
9Hyperlipoproteinemia (HP:0010980)5.61290848
10Joint hemorrhage (HP:0005261)5.04313074
11Hypolipoproteinemia (HP:0010981)4.90778938
12* Abnormality of the common coagulation pathway (HP:0010990)4.62765593
13Epidermoid cyst (HP:0200040)4.55493989
14Hyperammonemia (HP:0001987)4.55298505
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.48487690
16Hypoalphalipoproteinemia (HP:0003233)4.37741455
17Hyperglycinemia (HP:0002154)4.33224075
18Abnormality of complement system (HP:0005339)4.27920208
19Abnormality of methionine metabolism (HP:0010901)4.25029766
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.21789206
21Ketosis (HP:0001946)4.15927730
22Fat malabsorption (HP:0002630)4.15388751
23Abnormality of aspartate family amino acid metabolism (HP:0010899)4.11865211
24Abnormality of glutamine family amino acid metabolism (HP:0010902)4.09713475
25Abnormality of the intrinsic pathway (HP:0010989)3.95049782
26Hypoglycemic coma (HP:0001325)3.86240992
27Abnormality of glycine metabolism (HP:0010895)3.79767807
28Abnormality of serine family amino acid metabolism (HP:0010894)3.79767807
29Abnormality of pyrimidine metabolism (HP:0004353)3.77085041
30Hyperglycinuria (HP:0003108)3.75960159
31Conjugated hyperbilirubinemia (HP:0002908)3.74416233
32Hypercholesterolemia (HP:0003124)3.60975222
33Hyperbilirubinemia (HP:0002904)3.30991581
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.22699905
35Abnormality of fatty-acid metabolism (HP:0004359)3.20350527
36Steatorrhea (HP:0002570)3.08285698
37Myocardial infarction (HP:0001658)3.06191130
38* Spontaneous abortion (HP:0005268)3.05533865
39Hypochromic microcytic anemia (HP:0004840)3.04771840
40Hepatocellular carcinoma (HP:0001402)3.01095153
41Abnormality of serum amino acid levels (HP:0003112)2.99857134
42Abnormality of nucleobase metabolism (HP:0010932)2.98957163
43Delayed CNS myelination (HP:0002188)2.95773528
44Systemic lupus erythematosus (HP:0002725)2.94392745
45Ketoacidosis (HP:0001993)2.94088934
46Osteomalacia (HP:0002749)2.85694869
47Skin nodule (HP:0200036)2.82147506
48Glomerulonephritis (HP:0000099)2.75229229
49Acanthocytosis (HP:0001927)2.70095465
50Purpura (HP:0000979)2.67706306
51Metabolic acidosis (HP:0001942)2.67213746
52Abnormality of purine metabolism (HP:0004352)2.59893224
53Recurrent gram-negative bacterial infections (HP:0005420)2.54922356
54Hypoglycemic seizures (HP:0002173)2.54814351
55Vascular calcification (HP:0004934)2.54770071
56Lethargy (HP:0001254)2.53274879
57Spastic diplegia (HP:0001264)2.48612637
58Abnormal gallbladder morphology (HP:0012437)2.46961897
59Dicarboxylic aciduria (HP:0003215)2.44048081
60Abnormality of dicarboxylic acid metabolism (HP:0010995)2.44048081
61Mitral stenosis (HP:0001718)2.43115588
62Cholelithiasis (HP:0001081)2.42367548
63Gout (HP:0001997)2.39806429
64Cholecystitis (HP:0001082)2.35446901
65Abnormal gallbladder physiology (HP:0012438)2.35446901
66Cerebral edema (HP:0002181)2.35155798
67Irritability (HP:0000737)2.32013648
68Neonatal onset (HP:0003623)2.31110352
69Esophageal varix (HP:0002040)2.27391906
70Cardiovascular calcification (HP:0011915)2.25913541
71Menorrhagia (HP:0000132)2.25465861
72Malnutrition (HP:0004395)2.24390438
73* Gingival bleeding (HP:0000225)2.23210520
74Sensorimotor neuropathy (HP:0007141)2.14852971
75Late onset (HP:0003584)2.14270127
76Pancreatitis (HP:0001733)2.11974694
77* Thrombophlebitis (HP:0004418)2.11576121
78Poikilocytosis (HP:0004447)2.11270173
79Abnormal tarsal ossification (HP:0008369)2.11129258
80Arthropathy (HP:0003040)2.10788095
81Enlarged kidneys (HP:0000105)2.10567456
82Hyperinsulinemic hypoglycemia (HP:0000825)2.07348877
83* Joint swelling (HP:0001386)2.07101570
84Brushfield spots (HP:0001088)2.05409349
85Abnormality of iron homeostasis (HP:0011031)2.05132116
86Hemorrhage of the eye (HP:0011885)2.04224098
87Vomiting (HP:0002013)2.02667033
88Abnormality of transition element cation homeostasis (HP:0011030)2.00745334
89Increased serum pyruvate (HP:0003542)1.99943081
90Abnormality of the gallbladder (HP:0005264)1.99629938
91Opisthotonus (HP:0002179)1.98439547
92Increased serum ferritin (HP:0003281)1.97919016
93Fair hair (HP:0002286)1.97650678
94Retinal atrophy (HP:0001105)1.96093143
95Nephritis (HP:0000123)1.92839198
96Generalized aminoaciduria (HP:0002909)1.91868532
97* Abnormal delivery (HP:0001787)1.91728460
98Rickets (HP:0002748)1.89062468
99Elevated alkaline phosphatase (HP:0003155)1.86764576
100Hypophosphatemic rickets (HP:0004912)1.86147480
101Abnormality of the Achilles tendon (HP:0005109)1.84603737
102Elevated hepatic transaminases (HP:0002910)1.81677889
103Hyperphosphaturia (HP:0003109)1.80144147
104Glycosuria (HP:0003076)1.79522810
105Abnormality of urine glucose concentration (HP:0011016)1.79522810
106Abnormal cartilage morphology (HP:0002763)1.78457296
107Abnormal enzyme/coenzyme activity (HP:0012379)1.77999036
108Status epilepticus (HP:0002133)1.77635518
109Abnormality of carpal bone ossification (HP:0006257)1.76399098
110Abnormality of proline metabolism (HP:0010907)1.76178243
111Hydroxyprolinuria (HP:0003080)1.76178243
112Alkalosis (HP:0001948)1.75910712
113Renal cortical cysts (HP:0000803)1.75882329
114Abnormality of alkaline phosphatase activity (HP:0004379)1.75478630
115* Epistaxis (HP:0000421)1.75031964
116Hyperglycemia (HP:0003074)1.73961620
117Abnormality of glycolysis (HP:0004366)1.73913195
118Pulmonary embolism (HP:0002204)1.73311213
119Abnormality of vitamin metabolism (HP:0100508)1.69958421
120Facial shape deformation (HP:0011334)1.62541887
121Potter facies (HP:0002009)1.62541887
122Reduced antithrombin III activity (HP:0001976)1.55958724
123Bifid scrotum (HP:0000048)1.53023841
124Flat acetabular roof (HP:0003180)1.52948296
125Abnormal urine phosphate concentration (HP:0012599)1.50956023
126Gangrene (HP:0100758)1.50555944
127Proximal tubulopathy (HP:0000114)1.50108375
128Cerebral palsy (HP:0100021)1.47774325
129Increased mean platelet volume (HP:0011877)1.42802447

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.74269078
2ERN15.19420969
3FGFR44.82014506
4SIK14.18765299
5PDK23.62688562
6ERBB43.34372592
7TAOK33.16600316
8INSRR3.02562972
9MAP2K42.28974194
10MST1R2.13511089
11MAPK112.07600618
12PKN21.91641654
13PDGFRA1.89137506
14TRIB31.83630128
15TYK21.82515449
16PIK3CG1.79739607
17LATS11.72685660
18AKT31.71754728
19FLT31.69252596
20DAPK21.67186673
21CDK121.66429891
22MAP3K21.66011649
23WNK41.64884972
24NTRK31.63783474
25PTK61.62059551
26NEK91.49003188
27FGFR11.46286300
28ABL21.39943394
29JAK21.34616914
30TYRO31.33586189
31FRK1.32591865
32KDR1.30481892
33FGFR21.29160575
34LMTK21.28853493
35EPHA31.22012926
36ERBB21.21408939
37EPHB11.19054238
38MAP3K71.17649592
39JAK11.14860852
40PRKAA21.09217372
41GRK61.08244277
42NLK1.05747857
43TBK11.03891737
44MAP2K31.00319159
45PINK10.96456671
46EIF2AK10.95903869
47MAPK40.95402514
48MAP3K140.95079509
49SCYL20.95072789
50MAP3K100.91262438
51MET0.89354004
52FER0.89049891
53PRKCZ0.86062482
54MAP3K120.82855249
55MAPK150.82822005
56MAP3K30.81490382
57MAPK120.76664884
58CAMK2G0.76532195
59MAP3K110.75722892
60STK38L0.75390950
61CDK60.74672023
62TIE10.73421154
63RIPK10.73389499
64KSR20.72412269
65CAMK1D0.71147595
66FGFR30.70032956
67EPHA20.69876671
68DYRK1B0.68694690
69GSK3A0.67059791
70CSK0.66296600
71PRKAA10.65287554
72* PRKACG0.64188460
73CSNK1D0.63905358
74SGK30.61858076
75RPS6KB10.60190032
76PKN10.58257734
77BRSK20.57049065
78TGFBR20.56633837
79MAP2K60.56153218
80MAPKAPK30.55972767
81PTK20.55443920
82MAPK70.54545710
83WNK10.54319914
84IKBKE0.53560291
85CSF1R0.52907888
86NEK10.50667491
87IRAK30.49859401
88PDPK10.49431284
89SRC0.46817030
90* CSNK1E0.46409217
91SGK20.45999838
92PRKCQ0.45478089
93SGK10.45244832
94MAP2K10.44585821
95MAP3K50.44385191
96PDGFRB0.43977197
97BCR0.43902830
98DDR20.43575998
99CSNK2A20.42638241
100PRKACA0.42543963
101RET0.41986094
102IGF1R0.41670108
103EEF2K0.41604113
104EIF2AK30.41432236
105ACVR1B0.40629465
106MAP3K130.40403928
107CSNK1G10.40361479
108FGR0.40005015
109GRK10.39590997
110RPS6KA30.39193600
111MTOR0.38666910
112EPHA40.38492688
113PRKCG0.38200791
114EGFR0.37321175
115CDK70.37101745
116ICK0.36954125
117CAMKK20.36843382
118CDK40.36773840
119TAOK20.36492655
120ZAP700.36485492
121CDC42BPA0.35927622
122MAP3K60.35717304
123CDK90.34065485
124MAP3K10.33363974
125IRAK10.32776573
126SGK2230.32227470
127SGK4940.32227470
128CAMK40.32016201
129PDK10.27975790
130PBK0.27229132
131LATS20.26409099
132CAMK1G0.25437431
133PRKCA0.24570818
134PIK3CA0.23794565
135PAK30.23520438
136BMX0.22639515
137ABL10.22266928
138CSNK1G20.18394821
139MAPK30.18270832
140KIT0.16119577
141CSNK1G30.15019187

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.54620550
2Nitrogen metabolism_Homo sapiens_hsa009103.80059502
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.47333462
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.23382275
5Arginine biosynthesis_Homo sapiens_hsa002203.13808769
6* Complement and coagulation cascades_Homo sapiens_hsa046103.00137539
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.67804002
8Tryptophan metabolism_Homo sapiens_hsa003802.63953787
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.62641009
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.58269883
11Fatty acid degradation_Homo sapiens_hsa000712.46982746
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.32828466
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.13724139
14Butanoate metabolism_Homo sapiens_hsa006502.10747012
15Peroxisome_Homo sapiens_hsa041462.06565032
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.04513138
17Staphylococcus aureus infection_Homo sapiens_hsa051501.98966882
18Propanoate metabolism_Homo sapiens_hsa006401.88163601
19Chemical carcinogenesis_Homo sapiens_hsa052041.88063427
20Histidine metabolism_Homo sapiens_hsa003401.87962691
21PPAR signaling pathway_Homo sapiens_hsa033201.87649046
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.83442965
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.82571985
24Fatty acid metabolism_Homo sapiens_hsa012121.79589981
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.76554454
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.70478559
27Caffeine metabolism_Homo sapiens_hsa002321.66926248
28beta-Alanine metabolism_Homo sapiens_hsa004101.66383268
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.61385669
30Retinol metabolism_Homo sapiens_hsa008301.60906884
31Selenocompound metabolism_Homo sapiens_hsa004501.58324655
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57654496
33Phenylalanine metabolism_Homo sapiens_hsa003601.56439110
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52027129
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50756645
36Bile secretion_Homo sapiens_hsa049761.48104753
37Tyrosine metabolism_Homo sapiens_hsa003501.43809077
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.33885187
39Pyruvate metabolism_Homo sapiens_hsa006201.32895813
40Sulfur metabolism_Homo sapiens_hsa009201.28893851
41Fatty acid elongation_Homo sapiens_hsa000621.28339202
42Starch and sucrose metabolism_Homo sapiens_hsa005001.23646311
43Steroid biosynthesis_Homo sapiens_hsa001001.23186237
44ABC transporters_Homo sapiens_hsa020101.21959614
45Biosynthesis of amino acids_Homo sapiens_hsa012301.21706848
46Fat digestion and absorption_Homo sapiens_hsa049751.21463857
47Folate biosynthesis_Homo sapiens_hsa007901.19715790
48Carbon metabolism_Homo sapiens_hsa012001.12290625
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.07001030
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02227054
51Vitamin B6 metabolism_Homo sapiens_hsa007500.98608840
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.97927225
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97658625
54Arginine and proline metabolism_Homo sapiens_hsa003300.94174159
55Sulfur relay system_Homo sapiens_hsa041220.93159270
56Vitamin digestion and absorption_Homo sapiens_hsa049770.91397510
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89895757
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84925587
59Lysine degradation_Homo sapiens_hsa003100.80348904
60One carbon pool by folate_Homo sapiens_hsa006700.77637511
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68730477
62Glycerolipid metabolism_Homo sapiens_hsa005610.65962806
63Glutathione metabolism_Homo sapiens_hsa004800.62761434
64Pentose phosphate pathway_Homo sapiens_hsa000300.58818169
65Other glycan degradation_Homo sapiens_hsa005110.55161854
66Fatty acid biosynthesis_Homo sapiens_hsa000610.52523250
67Metabolic pathways_Homo sapiens_hsa011000.44761500
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44622272
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44179148
70Prion diseases_Homo sapiens_hsa050200.42331420
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26733724
72Galactose metabolism_Homo sapiens_hsa000520.25277899
73Insulin resistance_Homo sapiens_hsa049310.24982525
74Fructose and mannose metabolism_Homo sapiens_hsa000510.24784780
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.24331363
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19287339
77Linoleic acid metabolism_Homo sapiens_hsa005910.18967943
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.16555832
79Glucagon signaling pathway_Homo sapiens_hsa049220.11526518
80N-Glycan biosynthesis_Homo sapiens_hsa005100.07552730
81Sphingolipid metabolism_Homo sapiens_hsa006000.04616086
82Mineral absorption_Homo sapiens_hsa049780.04559950
83AMPK signaling pathway_Homo sapiens_hsa041520.02491036
84Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2410047
85Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2320834
86Pertussis_Homo sapiens_hsa05133-0.2198642
87Circadian rhythm_Homo sapiens_hsa04710-0.2192603
88Amoebiasis_Homo sapiens_hsa05146-0.2190130
89Bladder cancer_Homo sapiens_hsa05219-0.1991739
90Ether lipid metabolism_Homo sapiens_hsa00565-0.1966207
91Serotonergic synapse_Homo sapiens_hsa04726-0.1887256
92Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1881690
93Renin-angiotensin system_Homo sapiens_hsa04614-0.1856403
94Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1807881
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1570082
96Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1556808
97Regulation of autophagy_Homo sapiens_hsa04140-0.1551776
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1548967
99Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1466778
100Hepatitis C_Homo sapiens_hsa05160-0.1347813
101African trypanosomiasis_Homo sapiens_hsa05143-0.1297235
102ECM-receptor interaction_Homo sapiens_hsa04512-0.1169991
103Insulin signaling pathway_Homo sapiens_hsa04910-0.1018000
104Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0758786
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0681815
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0662562
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0626254
108Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0594362

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