FGB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)7.57888303
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.56968055
3L-phenylalanine catabolic process (GO:0006559)7.56968055
4L-phenylalanine metabolic process (GO:0006558)7.22827311
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.22827311
6epoxygenase P450 pathway (GO:0019373)7.12014077
7omega-hydroxylase P450 pathway (GO:0097267)6.95196268
8aromatic amino acid family catabolic process (GO:0009074)6.74894726
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.45456967
10tryptophan catabolic process (GO:0006569)6.07963914
11indole-containing compound catabolic process (GO:0042436)6.07963914
12indolalkylamine catabolic process (GO:0046218)6.07963914
13kynurenine metabolic process (GO:0070189)5.97990443
14negative regulation of fibrinolysis (GO:0051918)5.90284118
15bile acid biosynthetic process (GO:0006699)5.87428168
16glyoxylate metabolic process (GO:0046487)5.85162144
17tryptophan metabolic process (GO:0006568)5.73045974
18urea metabolic process (GO:0019627)5.72199706
19urea cycle (GO:0000050)5.72199706
20regulation of protein activation cascade (GO:2000257)5.71664650
21regulation of fibrinolysis (GO:0051917)5.69090908
22high-density lipoprotein particle remodeling (GO:0034375)5.65862279
23complement activation, alternative pathway (GO:0006957)5.59460439
24alpha-linolenic acid metabolic process (GO:0036109)5.54336799
25peptidyl-glutamic acid carboxylation (GO:0017187)5.51622180
26protein carboxylation (GO:0018214)5.51622180
27cysteine metabolic process (GO:0006534)5.35658340
28sulfur amino acid catabolic process (GO:0000098)5.28755443
29regulation of plasminogen activation (GO:0010755)5.26490030
30regulation of complement activation (GO:0030449)5.25833255
31nitrogen cycle metabolic process (GO:0071941)5.25353078
32* positive regulation of heterotypic cell-cell adhesion (GO:0034116)5.24202441
33drug metabolic process (GO:0017144)5.09374445
34serine family amino acid catabolic process (GO:0009071)5.09214249
35regulation of humoral immune response (GO:0002920)5.08402013
36reverse cholesterol transport (GO:0043691)5.03725536
37bile acid metabolic process (GO:0008206)5.03386407
38regulation of cholesterol esterification (GO:0010872)4.93274226
39regulation of triglyceride catabolic process (GO:0010896)4.93222077
40macromolecular complex remodeling (GO:0034367)4.90786380
41plasma lipoprotein particle remodeling (GO:0034369)4.90786380
42protein-lipid complex remodeling (GO:0034368)4.90786380
43aromatic amino acid family metabolic process (GO:0009072)4.90137790
44fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.86866401
45tyrosine metabolic process (GO:0006570)4.79263007
46homocysteine metabolic process (GO:0050667)4.76170198
47negative regulation of blood coagulation (GO:0030195)4.75792985
48negative regulation of hemostasis (GO:1900047)4.75792985
49triglyceride homeostasis (GO:0070328)4.70963376
50acylglycerol homeostasis (GO:0055090)4.70963376
51phospholipid efflux (GO:0033700)4.67680556
52oxidative demethylation (GO:0070989)4.67293628
53ethanol metabolic process (GO:0006067)4.62079325
54alpha-amino acid catabolic process (GO:1901606)4.60341115
55amino-acid betaine metabolic process (GO:0006577)4.55830714
56lysine catabolic process (GO:0006554)4.54299717
57lysine metabolic process (GO:0006553)4.54299717
58intestinal cholesterol absorption (GO:0030299)4.53739212
59negative regulation of sterol transport (GO:0032372)4.52080172
60negative regulation of cholesterol transport (GO:0032375)4.52080172
61plasma lipoprotein particle clearance (GO:0034381)4.49097776
62glycine metabolic process (GO:0006544)4.40102391
63cellular ketone body metabolic process (GO:0046950)4.39282267
64bile acid and bile salt transport (GO:0015721)4.36448044
65negative regulation of coagulation (GO:0050819)4.34873512
66cholesterol efflux (GO:0033344)4.34689454
67imidazole-containing compound metabolic process (GO:0052803)4.34586566
68coenzyme catabolic process (GO:0009109)4.31654579
69indolalkylamine metabolic process (GO:0006586)4.30874830
70negative regulation of wound healing (GO:0061045)4.30130221
71glutamate metabolic process (GO:0006536)4.25937866
72cellular amino acid catabolic process (GO:0009063)4.22201546
73disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.21616789
74killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.21616789
75amine catabolic process (GO:0009310)4.19958494
76cellular biogenic amine catabolic process (GO:0042402)4.19958494
77fibrinolysis (GO:0042730)4.19405471
78serine family amino acid metabolic process (GO:0009069)4.16010971
79plasma lipoprotein particle assembly (GO:0034377)4.13410273
80positive regulation of blood coagulation (GO:0030194)4.11263050
81positive regulation of hemostasis (GO:1900048)4.11263050
82protein-lipid complex subunit organization (GO:0071825)4.11055974
83cellular glucuronidation (GO:0052695)4.09094419
84regulation of apoptotic cell clearance (GO:2000425)4.07922002
85low-density lipoprotein particle remodeling (GO:0034374)4.07135265
86blood coagulation, intrinsic pathway (GO:0007597)4.06398942
87phenylpropanoid metabolic process (GO:0009698)4.06274785
88dicarboxylic acid biosynthetic process (GO:0043650)4.05850257
89cellular modified amino acid catabolic process (GO:0042219)4.05213139
90benzene-containing compound metabolic process (GO:0042537)4.04520278
91serine family amino acid biosynthetic process (GO:0009070)4.02966147
92arginine metabolic process (GO:0006525)4.02089324
93negative regulation of protein activation cascade (GO:2000258)4.01322670
94aldehyde catabolic process (GO:0046185)4.00393120
95ethanol oxidation (GO:0006069)3.95824468
96protein activation cascade (GO:0072376)3.91895158
97positive regulation of lipoprotein lipase activity (GO:0051006)3.91182706
98positive regulation of triglyceride lipase activity (GO:0061365)3.91182706
99complement activation, classical pathway (GO:0006958)3.90904028
100acute-phase response (GO:0006953)3.89687260
101complement activation (GO:0006956)3.86989312
102phospholipid homeostasis (GO:0055091)3.85216239
103drug catabolic process (GO:0042737)3.81022538
104negative regulation of complement activation (GO:0045916)3.80688300
105ketone body metabolic process (GO:1902224)3.80076862
106heme transport (GO:0015886)3.80047262
107cofactor catabolic process (GO:0051187)3.79105430
108positive regulation of coagulation (GO:0050820)3.79081555
109very-low-density lipoprotein particle assembly (GO:0034379)3.79070220
110cholesterol homeostasis (GO:0042632)3.78239173
111positive regulation of lipid catabolic process (GO:0050996)3.77790111
112acute inflammatory response (GO:0002526)3.77001984
113plasma lipoprotein particle organization (GO:0071827)3.74958788
114negative regulation of lipase activity (GO:0060192)3.74826147
115S-adenosylmethionine metabolic process (GO:0046500)3.74632103
116opsonization (GO:0008228)3.73036741
117sterol homeostasis (GO:0055092)3.71985428
118protein-lipid complex assembly (GO:0065005)3.70442667
119regulation of cholesterol homeostasis (GO:2000188)3.69857731
120cytolysis (GO:0019835)3.69644608
121organic acid catabolic process (GO:0016054)3.68212486
122carboxylic acid catabolic process (GO:0046395)3.68212486
123regulation of bile acid biosynthetic process (GO:0070857)3.67365003
124glucuronate metabolic process (GO:0019585)3.62145569
125uronic acid metabolic process (GO:0006063)3.62145569
126acetyl-CoA metabolic process (GO:0006084)3.59894047
127flavonoid metabolic process (GO:0009812)3.56693793
128positive regulation of fatty acid biosynthetic process (GO:0045723)3.52374921
129lipoprotein metabolic process (GO:0042157)3.49154790
130hormone catabolic process (GO:0042447)3.48150708
131regulation of acute inflammatory response (GO:0002673)3.41898729

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.37762805
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.18310848
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.98918732
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.50188770
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.32834058
6* CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.19333990
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.80863193
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.13425568
9* NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.05371768
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.06122846
11* ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.0692905
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.99384867
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93699431
14* FOXA2_19822575_ChIP-Seq_HepG2_Human1.62762865
15CLOCK_20551151_ChIP-Seq_293T_Human1.57932595
16GATA1_22025678_ChIP-Seq_K562_Human1.51782234
17* HTT_18923047_ChIP-ChIP_STHdh_Human1.42166416
18* HNF4A_19822575_ChIP-Seq_HepG2_Human1.41221059
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39073151
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.33424415
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.28841362
22ESR1_15608294_ChIP-ChIP_MCF-7_Human1.20469024
23RXRA_24833708_ChIP-Seq_LIVER_Mouse1.19967349
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19601965
25TRIM28_21343339_ChIP-Seq_HEK293_Human1.16164756
26PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.02677521
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01181679
28FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99103438
29ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97920032
30CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94154597
31TCF4_18268006_ChIP-ChIP_LS174T_Human0.93328366
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.92075247
33SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91353686
34IRF8_22096565_ChIP-ChIP_GC-B_Human0.90233817
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.87114094
36PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86178410
37AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82919951
38PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.82147888
39ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81620366
40RARG_19884340_ChIP-ChIP_MEFs_Mouse0.81403978
41GATA4_25053715_ChIP-Seq_YYC3_Human0.79128110
42BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78490942
43SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77228622
44ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.75125054
45SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.74135714
46ZNF263_19887448_ChIP-Seq_K562_Human0.73850773
47RARA_24833708_ChIP-Seq_LIVER_Mouse0.73352195
48CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.72050720
49KAP1_22055183_ChIP-Seq_ESCs_Mouse0.71885449
50Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.71856347
51NFE2_27457419_Chip-Seq_LIVER_Mouse0.70125136
52SALL4_18804426_ChIP-ChIP_XEN_Mouse0.69674271
53CDX2_19796622_ChIP-Seq_MESCs_Mouse0.69519203
54AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.68319919
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.67692109
56ESR2_21235772_ChIP-Seq_MCF-7_Human0.66743824
57ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.65707957
58NRF2_20460467_ChIP-Seq_MEFs_Mouse0.63426558
59NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.63426558
60TP53_18474530_ChIP-ChIP_U2OS_Human0.62237492
61RARB_24833708_ChIP-Seq_LIVER_Mouse0.62114741
62NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.60821498
63PIAS1_25552417_ChIP-Seq_VCAP_Human0.60006681
64RAD21_21589869_ChIP-Seq_MESCs_Mouse0.59273727
65FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.58862566
66HNFA_21074721_ChIP-Seq_CACO-2_Human0.58370795
67BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.57892558
68NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.57838941
69CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.57407693
70CEBPB_22108803_ChIP-Seq_LS180_Human0.56302507
71SMAD1_18555785_Chip-Seq_ESCs_Mouse0.56100994
72NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.55686583
73SOX2_21211035_ChIP-Seq_LN229_Human0.55371800
74STAT3_1855785_ChIP-Seq_MESCs_Mouse0.55199612
75EZH2_27294783_Chip-Seq_NPCs_Mouse0.55037880
76OCT4_18555785_Chip-Seq_ESCs_Mouse0.54936710
77TP53_16413492_ChIP-PET_HCT116_Human0.54662207
78EGR1_19032775_ChIP-ChIP_M12_Human0.54161608
79FOXA1_25552417_ChIP-Seq_VCAP_Human0.53794030
80CDX2_22108803_ChIP-Seq_LS180_Human0.53147699
81LXR_22292898_ChIP-Seq_THP-1_Human0.52658838
82AR_20517297_ChIP-Seq_VCAP_Human0.52214118
83SUZ12_27294783_Chip-Seq_NPCs_Mouse0.52178369
84PHF8_20622853_ChIP-Seq_HELA_Human0.51922134
85AR_21909140_ChIP-Seq_LNCAP_Human0.51876494
86GATA3_24758297_ChIP-Seq_MCF-7_Human0.51800405
87FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.51679285
88POU5F1_16518401_ChIP-PET_MESCs_Mouse0.51659910
89PCGF2_27294783_Chip-Seq_NPCs_Mouse0.51090549
90MYC_19915707_ChIP-ChIP_AK7_Human0.50517280
91ESRRB_18555785_Chip-Seq_ESCs_Mouse0.50300294
92* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.49310475
93PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.49211706
94CBX2_22325352_ChIP-Seq_293T-Rex_Human0.49010884
95RAC3_21632823_ChIP-Seq_H3396_Human0.47728474
96RUNX1_27457419_Chip-Seq_LIVER_Mouse0.47541060
97CBP_21632823_ChIP-Seq_H3396_Human0.47152238
98GATA1_19941826_ChIP-Seq_K562_Human0.47052530
99ESR1_21235772_ChIP-Seq_MCF-7_Human0.46782194
100ETV2_25802403_ChIP-Seq_MESCs_Mouse0.46396634
101P53_21459846_ChIP-Seq_SAOS-2_Human0.45906597
102ESET_19884257_ChIP-Seq_ESCs_Mouse0.45807644
103PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.45219893
104NFYA_21822215_ChIP-Seq_K562_Human0.44913392
105PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.44851721
106CDX2_20551321_ChIP-Seq_CACO-2_Human0.44239864
107STAT1_17558387_ChIP-Seq_HELA_Human0.43989937
108NFIB_24661679_ChIP-Seq_LUNG_Mouse0.43961971
109FOXO3_23340844_ChIP-Seq_DLD1_Human0.43241094
110FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.43015414
111TAF2_19829295_ChIP-Seq_ESCs_Human0.42573807
112GATA1_19941827_ChIP-Seq_MEL_Mouse0.42513374
113GATA2_19941826_ChIP-Seq_K562_Human0.42262075
114TAF15_26573619_Chip-Seq_HEK293_Human0.41606394
115ESR1_20079471_ChIP-ChIP_T-47D_Human0.41469991
116E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.40778791
117PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.40511413
118GATA6_25053715_ChIP-Seq_YYC3_Human0.40263487
119SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40138718
120PPAR_26484153_Chip-Seq_NCI-H1993_Human0.39716050
121STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.39449853
122MYC_27129775_Chip-Seq_CORNEA_Mouse0.38608478
123CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.38192162
124BCAT_22108803_ChIP-Seq_LS180_Human0.37378502
125ERG_21242973_ChIP-ChIP_JURKAT_Human0.37114241
126IRF1_19129219_ChIP-ChIP_H3396_Human0.36325967
127FOXH1_21741376_ChIP-Seq_EPCs_Human0.34281876
128ERG_20517297_ChIP-Seq_VCAP_Human0.33888274
129LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.33562184
130SPI1_26923725_Chip-Seq_HPCs_Mouse0.33552362
131SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.33333859
132BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.32948138
133SOX2_20726797_ChIP-Seq_SW620_Human0.32868467

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.16259146
2MP0005360_urolithiasis7.50456928
3MP0005085_abnormal_gallbladder_physiolo6.42384532
4MP0005365_abnormal_bile_salt6.11068538
5MP0008875_abnormal_xenobiotic_pharmacok5.02243748
6MP0003806_abnormal_nucleotide_metabolis4.26289197
7MP0003252_abnormal_bile_duct3.89005220
8MP0010329_abnormal_lipoprotein_level3.64597781
9MP0009840_abnormal_foam_cell3.33293770
10MP0005083_abnormal_biliary_tract3.18123004
11MP0003195_calcinosis2.82556812
12MP0005332_abnormal_amino_acid2.73528135
13MP0003191_abnormal_cellular_cholesterol2.60368718
14MP0001666_abnormal_nutrient_absorption2.58695380
15MP0000609_abnormal_liver_physiology2.20450954
16MP0004019_abnormal_vitamin_homeostasis2.13225542
17MP0002118_abnormal_lipid_homeostasis2.10458671
18MP0002138_abnormal_hepatobiliary_system1.98677272
19MP0003868_abnormal_feces_composition1.88058054
20MP0005319_abnormal_enzyme/_coenzyme1.82379197
21MP0001764_abnormal_homeostasis1.64074384
22MP0009697_abnormal_copulation1.60426223
23MP0005584_abnormal_enzyme/coenzyme_acti1.57469664
24MP0003011_delayed_dark_adaptation1.50927225
25MP0005451_abnormal_body_composition1.37871792
26MP0003656_abnormal_erythrocyte_physiolo1.34863060
27MP0003186_abnormal_redox_activity1.24082576
28MP0009643_abnormal_urine_homeostasis1.21924854
29MP0000598_abnormal_liver_morphology1.21112145
30MP0003705_abnormal_hypodermis_morpholog1.19669713
31MP0000604_amyloidosis1.18451503
32MP0001915_intracranial_hemorrhage1.14239463
33MP0002254_reproductive_system_inflammat1.13418356
34MP0005647_abnormal_sex_gland1.12454093
35MP0009764_decreased_sensitivity_to1.09419465
36MP0009763_increased_sensitivity_to1.07270527
37MP0010368_abnormal_lymphatic_system1.06026383
38MP0005636_abnormal_mineral_homeostasis0.94786126
39MP0008469_abnormal_protein_level0.92408999
40MP0009642_abnormal_blood_homeostasis0.88681572
41MP0005058_abnormal_lysosome_morphology0.87694286
42MP0005408_hypopigmentation0.84589489
43MP0003122_maternal_imprinting0.83736024
44MP0005670_abnormal_white_adipose0.81288823
45MP0009765_abnormal_xenobiotic_induced0.80901040
46MP0005376_homeostasis/metabolism_phenot0.79873195
47MP0005084_abnormal_gallbladder_morpholo0.79210131
48MP0006036_abnormal_mitochondrial_physio0.78946025
49MP0005023_abnormal_wound_healing0.77909439
50MP0002078_abnormal_glucose_homeostasis0.77754125
51MP0004272_abnormal_basement_membrane0.77545340
52MP0005220_abnormal_exocrine_pancreas0.77348617
53MP0002971_abnormal_brown_adipose0.74430444
54MP0000566_synostosis0.72327955
55MP0001661_extended_life_span0.72214345
56MP0002876_abnormal_thyroid_physiology0.71906328
57MP0003690_abnormal_glial_cell0.69477046
58MP0002282_abnormal_trachea_morphology0.69431319
59MP0005334_abnormal_fat_pad0.68576819
60MP0009053_abnormal_anal_canal0.68471638
61MP0002089_abnormal_postnatal_growth/wei0.67142612
62MP0003879_abnormal_hair_cell0.66721831
63MP0004130_abnormal_muscle_cell0.66348675
64MP0005535_abnormal_body_temperature0.65441749
65MP0005464_abnormal_platelet_physiology0.64753583
66MP0000639_abnormal_adrenal_gland0.63483996
67MP0005266_abnormal_metabolism0.62951179
68MP0003329_amyloid_beta_deposits0.61912508
69MP0001756_abnormal_urination0.57399557
70MP0006035_abnormal_mitochondrial_morpho0.55805263
71MP0005448_abnormal_energy_balance0.55554237
72MP0005187_abnormal_penis_morphology0.54408082
73MP0005395_other_phenotype0.51821441
74MP0003436_decreased_susceptibility_to0.49913038
75MP0003724_increased_susceptibility_to0.48031323
76MP0003638_abnormal_response/metabolism_0.46027244
77MP0002928_abnormal_bile_duct0.45679250
78MP0008873_increased_physiological_sensi0.45588668
79MP0002136_abnormal_kidney_physiology0.45572223
80MP0003718_maternal_effect0.45337956
81MP0003941_abnormal_skin_development0.44900592
82MP0005409_darkened_coat_color0.44877414
83MP0002822_catalepsy0.44370708
84MP0008874_decreased_physiological_sensi0.43376198
85MP0003075_altered_response_to0.42687534
86MP0003632_abnormal_nervous_system0.41473773
87MP0001986_abnormal_taste_sensitivity0.41268988
88MP0005166_decreased_susceptibility_to0.40869284
89MP0000920_abnormal_myelination0.40602770
90MP0000579_abnormal_nail_morphology0.40076614
91MP0003953_abnormal_hormone_level0.39931166
92MP0009384_cardiac_valve_regurgitation0.39431917
93MP0002837_dystrophic_cardiac_calcinosis0.39353152
94MP0005248_abnormal_Harderian_gland0.38935471
95MP0004782_abnormal_surfactant_physiolog0.38166103
96MP0002249_abnormal_larynx_morphology0.37998962
97MP0005666_abnormal_adipose_tissue0.37799111
98MP0004381_abnormal_hair_follicle0.34974257
99MP0009672_abnormal_birth_weight0.34927700
100MP0008872_abnormal_physiological_respon0.34563051
101MP0004883_abnormal_blood_vessel0.34520863
102MP0000249_abnormal_blood_vessel0.33852327
103MP0002796_impaired_skin_barrier0.33686898
104MP0002128_abnormal_blood_circulation0.32534782
105MP0009115_abnormal_fat_cell0.32511340
106MP0003123_paternal_imprinting0.32496334
107MP0001243_abnormal_dermal_layer0.32098424
108MP0006082_CNS_inflammation0.31749990
109MP0002168_other_aberrant_phenotype0.31163173
110MP0002970_abnormal_white_adipose0.30838807
111MP0003172_abnormal_lysosome_physiology0.30414214
112MP0003633_abnormal_nervous_system0.30299692
113MP0001845_abnormal_inflammatory_respons0.30182107
114MP0001881_abnormal_mammary_gland0.30042555
115MP0000230_abnormal_systemic_arterial0.29636267
116MP0001853_heart_inflammation0.29287949
117MP0005164_abnormal_response_to0.29083010
118MP0009785_altered_susceptibility_to0.28558876
119MP0000467_abnormal_esophagus_morphology0.27159417
120MP0003631_nervous_system_phenotype0.26988833
121MP0004264_abnormal_extraembryonic_tissu0.26489576
122MP0001944_abnormal_pancreas_morphology0.26350756
123MP0000427_abnormal_hair_cycle0.26280720
124MP0002132_abnormal_respiratory_system0.26140245
125MP0003699_abnormal_female_reproductive0.25520222
126MP0002909_abnormal_adrenal_gland0.24588166
127MP0009780_abnormal_chondrocyte_physiolo0.24553734
128MP0002135_abnormal_kidney_morphology0.24363381

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.58389590
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.32939611
3Intrahepatic cholestasis (HP:0001406)7.29655166
4Prolonged partial thromboplastin time (HP:0003645)6.79072198
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.64184949
6Hypobetalipoproteinemia (HP:0003563)6.46455350
7Xanthomatosis (HP:0000991)6.33796314
8Complement deficiency (HP:0004431)5.68089887
9Hyperlipoproteinemia (HP:0010980)5.62364416
10Joint hemorrhage (HP:0005261)4.99783292
11Hypolipoproteinemia (HP:0010981)4.91547877
12Hyperammonemia (HP:0001987)4.56896096
13Epidermoid cyst (HP:0200040)4.54433580
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.49637291
15* Abnormality of the common coagulation pathway (HP:0010990)4.48912143
16Hypoalphalipoproteinemia (HP:0003233)4.36442383
17Hyperglycinemia (HP:0002154)4.34727314
18Abnormality of methionine metabolism (HP:0010901)4.28818997
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.23336862
20Ketosis (HP:0001946)4.17322546
21Abnormality of complement system (HP:0005339)4.15576096
22Abnormality of aspartate family amino acid metabolism (HP:0010899)4.13402708
23Fat malabsorption (HP:0002630)4.12702396
24Abnormality of glutamine family amino acid metabolism (HP:0010902)4.12179299
25Abnormality of the intrinsic pathway (HP:0010989)3.90882422
26Hypoglycemic coma (HP:0001325)3.85513907
27Abnormality of glycine metabolism (HP:0010895)3.82800238
28Abnormality of serine family amino acid metabolism (HP:0010894)3.82800238
29Hyperglycinuria (HP:0003108)3.79954025
30Abnormality of pyrimidine metabolism (HP:0004353)3.78932774
31Conjugated hyperbilirubinemia (HP:0002908)3.72252929
32Hypercholesterolemia (HP:0003124)3.63946570
33Hyperbilirubinemia (HP:0002904)3.33547261
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.25981805
35Abnormality of fatty-acid metabolism (HP:0004359)3.23218328
36Hypochromic microcytic anemia (HP:0004840)3.05909202
37Steatorrhea (HP:0002570)3.05534486
38Hepatocellular carcinoma (HP:0001402)3.03741996
39Abnormality of serum amino acid levels (HP:0003112)3.02560649
40Myocardial infarction (HP:0001658)3.00513994
41Delayed CNS myelination (HP:0002188)2.99302366
42Abnormality of nucleobase metabolism (HP:0010932)2.98854554
43Ketoacidosis (HP:0001993)2.93902936
44Osteomalacia (HP:0002749)2.91489381
45Systemic lupus erythematosus (HP:0002725)2.86324175
46* Spontaneous abortion (HP:0005268)2.81591242
47Skin nodule (HP:0200036)2.81553812
48Acanthocytosis (HP:0001927)2.73016377
49Metabolic acidosis (HP:0001942)2.70104123
50Glomerulonephritis (HP:0000099)2.70087128
51Amyloidosis (HP:0011034)2.67521393
52Abnormality of purine metabolism (HP:0004352)2.58815445
53Purpura (HP:0000979)2.56416496
54Lethargy (HP:0001254)2.54763832
55Vascular calcification (HP:0004934)2.53833899
56Hypoglycemic seizures (HP:0002173)2.51163310
57Abnormal gallbladder morphology (HP:0012437)2.49467365
58Abnormality of dicarboxylic acid metabolism (HP:0010995)2.47729223
59Dicarboxylic aciduria (HP:0003215)2.47729223
60Spastic diplegia (HP:0001264)2.47023707
61Recurrent gram-negative bacterial infections (HP:0005420)2.46535757
62Cholelithiasis (HP:0001081)2.44306254
63Abnormal gallbladder physiology (HP:0012438)2.40209064
64Cholecystitis (HP:0001082)2.40209064
65Mitral stenosis (HP:0001718)2.39994705
66Gout (HP:0001997)2.38766102
67Cerebral edema (HP:0002181)2.37498653
68Irritability (HP:0000737)2.32198006
69Neonatal onset (HP:0003623)2.31378308
70Esophageal varix (HP:0002040)2.27730100
71Cardiovascular calcification (HP:0011915)2.25012714
72Malnutrition (HP:0004395)2.24991419
73Menorrhagia (HP:0000132)2.24077400
74Arthropathy (HP:0003040)2.18473639
75Poikilocytosis (HP:0004447)2.14011176
76Sensorimotor neuropathy (HP:0007141)2.13277309
77Pancreatitis (HP:0001733)2.12709112
78Enlarged kidneys (HP:0000105)2.11267401
79* Gingival bleeding (HP:0000225)2.10878361
80Late onset (HP:0003584)2.09882774
81Fair hair (HP:0002286)2.07754706
82Brushfield spots (HP:0001088)2.06669443
83* Thrombophlebitis (HP:0004418)2.04534904
84* Joint swelling (HP:0001386)2.04347927
85Retinal atrophy (HP:0001105)2.04307722
86Hyperinsulinemic hypoglycemia (HP:0000825)2.03877444
87Hemorrhage of the eye (HP:0011885)2.03292426
88Vomiting (HP:0002013)2.03030116
89Abnormality of the gallbladder (HP:0005264)2.01476161
90Increased serum ferritin (HP:0003281)1.99524356
91Abnormality of iron homeostasis (HP:0011031)1.98136923
92Abnormal tarsal ossification (HP:0008369)1.97864285
93Opisthotonus (HP:0002179)1.97607272
94Abnormality of transition element cation homeostasis (HP:0011030)1.94604566
95Generalized aminoaciduria (HP:0002909)1.93954965
96Abnormality of urine glucose concentration (HP:0011016)1.90574625
97Glycosuria (HP:0003076)1.90574625
98Hyperphosphaturia (HP:0003109)1.90381911
99Abnormality of the Achilles tendon (HP:0005109)1.90330729
100Rickets (HP:0002748)1.89034355
101Elevated alkaline phosphatase (HP:0003155)1.88810550
102Nephritis (HP:0000123)1.88585259
103Increased serum pyruvate (HP:0003542)1.85463751
104Hypophosphatemic rickets (HP:0004912)1.84894395
105Abnormal cartilage morphology (HP:0002763)1.81588509
106Elevated hepatic transaminases (HP:0002910)1.81431593
107Abnormality of vitamin metabolism (HP:0100508)1.80524567
108* Abnormal delivery (HP:0001787)1.79976150
109Hydroxyprolinuria (HP:0003080)1.78925988
110Abnormality of proline metabolism (HP:0010907)1.78925988
111Renal cortical cysts (HP:0000803)1.78209068
112Status epilepticus (HP:0002133)1.77704008
113Abnormal enzyme/coenzyme activity (HP:0012379)1.77616266
114Abnormality of alkaline phosphatase activity (HP:0004379)1.76891436
115Alkalosis (HP:0001948)1.76729432
116* Epistaxis (HP:0000421)1.75193941
117Pulmonary embolism (HP:0002204)1.73421064
118Reduced antithrombin III activity (HP:0001976)1.71765589
119Hyperglycemia (HP:0003074)1.70945953
120Neonatal hypoglycemia (HP:0001998)1.59712789
121Abnormality of glycolysis (HP:0004366)1.58949601
122Proximal tubulopathy (HP:0000114)1.57284181
123Abnormal urine phosphate concentration (HP:0012599)1.56434558
124Bifid scrotum (HP:0000048)1.54579987
125Cerebral palsy (HP:0100021)1.54221602
126Abnormality of carpal bone ossification (HP:0006257)1.53636893
127Potter facies (HP:0002009)1.51710528
128Facial shape deformation (HP:0011334)1.51710528
129Gangrene (HP:0100758)1.51582586

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.90699617
2ERN14.82676334
3FGFR44.75911927
4SIK14.31765461
5PDK23.77125299
6ERBB43.20320630
7TAOK33.08167397
8INSRR3.04946996
9PIK3CA2.49248116
10MAP2K42.31588791
11MST1R2.18304910
12PKN22.06683697
13MAPK112.04045664
14TRIB31.82726951
15MAP3K21.82248752
16TYK21.80547347
17NTRK31.80511406
18FLT31.79722968
19PIK3CG1.77721078
20LATS11.73066684
21AKT31.69431408
22PTK61.58690743
23DAPK21.57326714
24LMTK21.52401927
25NEK91.51241005
26PDGFRA1.50341710
27ABL21.43783866
28CDK121.36272637
29FRK1.35513507
30FGFR21.33466790
31KDR1.31753972
32JAK21.31272490
33WNK41.25794897
34MAP3K71.17252628
35FGFR11.16826106
36ERBB21.15931034
37NLK1.10981015
38JAK11.10896224
39PRKAA21.10181324
40GRK61.08349625
41ACVR1B1.08143455
42EPHA31.07743222
43EPHB11.06733694
44TBK11.04595002
45MAP2K31.03956304
46MAP3K121.03046215
47PINK11.02291338
48FER1.01626095
49MAPK40.96692121
50MAP3K100.95936689
51MAP3K140.94130845
52MET0.91006666
53PRKCZ0.87313623
54MAP3K30.86769148
55SCYL20.84104151
56TYRO30.83904692
57MAPK150.80403421
58CSNK1E0.79464080
59STK38L0.79028816
60CDK60.77708225
61TESK20.77546948
62EPHA20.77458185
63PRKACG0.77276743
64MAPK120.76913038
65MAP3K110.76311927
66CAMK2G0.74313890
67TIE10.73186391
68RIPK10.70954899
69PRKG10.70821909
70CAMK1D0.68561662
71GSK3A0.68433961
72DYRK1B0.67555755
73CSK0.67074391
74KSR20.67011617
75FGFR30.66591522
76PRKAA10.65100994
77MAPKAPK30.63933209
78BRSK20.63791553
79CSNK1D0.63035161
80EIF2AK30.61982324
81SGK30.61419776
82EIF2AK10.58740113
83TGFBR20.58628639
84MAP2K60.57994212
85PTK20.56679270
86CASK0.55142858
87MAPK70.54752154
88IKBKE0.53471970
89CSF1R0.53470729
90CAMKK20.51945246
91IRAK30.51920112
92RPS6KB10.51770630
93PKN10.50644478
94PDPK10.49019475
95PRKCB0.48559887
96PRKACA0.48429114
97PRKCQ0.47554924
98NEK10.45956724
99MAP3K50.45188654
100SGK20.45073981
101SRC0.44565478
102MAP2K10.44443984
103CSNK2A10.44204255
104CSNK2A20.43761938
105CSNK1G10.42606699
106RET0.42459528
107GRK10.42122866
108IGF1R0.41774424
109SGK10.40204201
110MAP3K60.39078496
111MAP3K130.38989801
112CDK40.38773554
113TAOK20.38469376
114EPHA40.38377443
115PRKCG0.38085145
116RPS6KA30.37864434
117EEF2K0.37749857
118MTOR0.37479187
119EGFR0.35903160
120PDGFRB0.34871210
121ICK0.33721591
122PBK0.33646168
123SGK4940.31770295
124SGK2230.31770295
125CAMK40.30957080
126MAP3K10.30665586
127PRPF4B0.30215772
128BCR0.29503345
129ZAP700.29264739
130IRAK10.29128323
131PDK10.28312515
132LATS20.25619172
133PRKCA0.24299580
134BMX0.23131458
135PAK30.23025986
136CAMK1G0.22052911
137ABL10.21881121
138CSNK1G20.20716029
139PRKACB0.20488945
140MAP2K20.19284159
141MAPK30.17723415
142CSNK1G30.17234811

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.51204332
2Nitrogen metabolism_Homo sapiens_hsa009103.81495294
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.46487021
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.26339413
5Arginine biosynthesis_Homo sapiens_hsa002203.14036056
6* Complement and coagulation cascades_Homo sapiens_hsa046102.93701949
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.67589307
8Tryptophan metabolism_Homo sapiens_hsa003802.64232175
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.63819633
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.57610626
11Fatty acid degradation_Homo sapiens_hsa000712.47777824
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.34026321
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.16220074
14Butanoate metabolism_Homo sapiens_hsa006502.11614857
15Peroxisome_Homo sapiens_hsa041462.05768754
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.04799481
17Staphylococcus aureus infection_Homo sapiens_hsa051501.93774537
18Propanoate metabolism_Homo sapiens_hsa006401.89059035
19Histidine metabolism_Homo sapiens_hsa003401.88706143
20Chemical carcinogenesis_Homo sapiens_hsa052041.88476521
21PPAR signaling pathway_Homo sapiens_hsa033201.86660012
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.85617679
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.83624306
24Fatty acid metabolism_Homo sapiens_hsa012121.79857495
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.77610441
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.71736526
27beta-Alanine metabolism_Homo sapiens_hsa004101.67681809
28Caffeine metabolism_Homo sapiens_hsa002321.67333366
29Retinol metabolism_Homo sapiens_hsa008301.63193243
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.61948758
31Selenocompound metabolism_Homo sapiens_hsa004501.60085832
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59491625
33Phenylalanine metabolism_Homo sapiens_hsa003601.56846512
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52434638
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50972378
36Bile secretion_Homo sapiens_hsa049761.47720732
37Tyrosine metabolism_Homo sapiens_hsa003501.44226270
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.34769312
39Pyruvate metabolism_Homo sapiens_hsa006201.33373681
40Sulfur metabolism_Homo sapiens_hsa009201.31136160
41Fatty acid elongation_Homo sapiens_hsa000621.29989940
42Starch and sucrose metabolism_Homo sapiens_hsa005001.24286141
43Steroid biosynthesis_Homo sapiens_hsa001001.22952547
44Biosynthesis of amino acids_Homo sapiens_hsa012301.22365623
45ABC transporters_Homo sapiens_hsa020101.21031218
46Fat digestion and absorption_Homo sapiens_hsa049751.20615043
47Folate biosynthesis_Homo sapiens_hsa007901.19517715
48Carbon metabolism_Homo sapiens_hsa012001.13094965
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.03626708
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02292816
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98859990
52Vitamin B6 metabolism_Homo sapiens_hsa007500.98129313
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.98032518
54Arginine and proline metabolism_Homo sapiens_hsa003300.94795296
55Sulfur relay system_Homo sapiens_hsa041220.93870528
56Vitamin digestion and absorption_Homo sapiens_hsa049770.89933767
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88825761
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84696870
59Lysine degradation_Homo sapiens_hsa003100.80493361
60One carbon pool by folate_Homo sapiens_hsa006700.78739730
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69340599
62Glycerolipid metabolism_Homo sapiens_hsa005610.65842234
63Glutathione metabolism_Homo sapiens_hsa004800.62109736
64Pentose phosphate pathway_Homo sapiens_hsa000300.59980225
65Fatty acid biosynthesis_Homo sapiens_hsa000610.53050115
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45408828
67Metabolic pathways_Homo sapiens_hsa011000.45225660
68Other glycan degradation_Homo sapiens_hsa005110.44019032
69Prion diseases_Homo sapiens_hsa050200.39301340
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38668311
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26519137
72Galactose metabolism_Homo sapiens_hsa000520.25260982
73Fructose and mannose metabolism_Homo sapiens_hsa000510.24486594
74Insulin resistance_Homo sapiens_hsa049310.24272117
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.23649052
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20497374
77Linoleic acid metabolism_Homo sapiens_hsa005910.20296176
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.16316107
79Glucagon signaling pathway_Homo sapiens_hsa049220.10622315
80Sphingolipid metabolism_Homo sapiens_hsa006000.04932869
81Mineral absorption_Homo sapiens_hsa049780.02989411
82AMPK signaling pathway_Homo sapiens_hsa041520.02284917
83N-Glycan biosynthesis_Homo sapiens_hsa005100.01877461
84Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2407917
85Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2319859
86Amoebiasis_Homo sapiens_hsa05146-0.2297636
87Pertussis_Homo sapiens_hsa05133-0.2277225
88Circadian rhythm_Homo sapiens_hsa04710-0.2166028
89Bladder cancer_Homo sapiens_hsa05219-0.2147818
90Ether lipid metabolism_Homo sapiens_hsa00565-0.1988575
91Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1914379
92Renin-angiotensin system_Homo sapiens_hsa04614-0.1859915
93Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1812363
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1697505
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1661225
96Serotonergic synapse_Homo sapiens_hsa04726-0.1633652
97ECM-receptor interaction_Homo sapiens_hsa04512-0.1586718
98Regulation of autophagy_Homo sapiens_hsa04140-0.1547160
99Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1543410
100Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1501610
101Hepatitis C_Homo sapiens_hsa05160-0.1482448
102African trypanosomiasis_Homo sapiens_hsa05143-0.1293825
103Insulin signaling pathway_Homo sapiens_hsa04910-0.1022713
104Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0739437
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0736142
106Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0729563
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0711312
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0591846

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