FGD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that contains Dbl (DH) and pleckstrin (PH) homology domains and is similar to the Rho family of small GTP-binding proteins. The encoded protein specifically binds to the Rho family GTPase Cdc42Hs and can stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. Defects in this gene are the cause of faciogenital dysplasia and X-linked mental retardation, syndromatic 16. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of posttranscriptional gene silencing (GO:0060147)5.56375677
2regulation of gene silencing by miRNA (GO:0060964)5.56375677
3regulation of gene silencing by RNA (GO:0060966)5.56375677
4paraxial mesoderm development (GO:0048339)4.68726394
5pre-miRNA processing (GO:0031054)4.62026827
6heterochromatin organization (GO:0070828)4.44707847
7nuclear pore organization (GO:0006999)4.37773927
8histone H4-K12 acetylation (GO:0043983)4.29249540
9nuclear pore complex assembly (GO:0051292)4.19419897
10protein localization to kinetochore (GO:0034501)4.08975238
11DNA unwinding involved in DNA replication (GO:0006268)4.07502128
12mitotic sister chromatid segregation (GO:0000070)3.94416542
13establishment of apical/basal cell polarity (GO:0035089)3.91976944
14regulation of hippo signaling (GO:0035330)3.90481601
15regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.89603517
16DNA replication-dependent nucleosome organization (GO:0034723)3.83081160
17DNA replication-dependent nucleosome assembly (GO:0006335)3.83081160
18somatic diversification of immune receptors via somatic mutation (GO:0002566)3.82549437
19somatic hypermutation of immunoglobulin genes (GO:0016446)3.82549437
20histone arginine methylation (GO:0034969)3.79429478
21formation of translation preinitiation complex (GO:0001731)3.65476708
22peptidyl-arginine omega-N-methylation (GO:0035247)3.64777890
23sister chromatid segregation (GO:0000819)3.64349900
24regulation of telomere maintenance via telomerase (GO:0032210)3.63710598
25anterior/posterior axis specification, embryo (GO:0008595)3.61955575
26mitotic nuclear envelope disassembly (GO:0007077)3.61859761
27establishment or maintenance of monopolar cell polarity (GO:0061339)3.60530042
28establishment of monopolar cell polarity (GO:0061162)3.60530042
29negative regulation of histone methylation (GO:0031061)3.51431485
30regulation of translational fidelity (GO:0006450)3.50170200
31convergent extension (GO:0060026)3.49451284
32neuron projection extension involved in neuron projection guidance (GO:1902284)3.46111099
33axon extension involved in axon guidance (GO:0048846)3.46111099
34membrane disassembly (GO:0030397)3.42119860
35nuclear envelope disassembly (GO:0051081)3.42119860
36notochord development (GO:0030903)3.40839748
37polarized epithelial cell differentiation (GO:0030859)3.38365804
38DNA duplex unwinding (GO:0032508)3.37198941
39negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.36499067
40positive regulation of SMAD protein import into nucleus (GO:0060391)3.35855003
41DNA geometric change (GO:0032392)3.35283174
42histone H4-K8 acetylation (GO:0043982)3.28739754
43histone H4-K5 acetylation (GO:0043981)3.28739754
44DNA replication initiation (GO:0006270)3.23322579
45peptidyl-arginine methylation (GO:0018216)3.22907921
46peptidyl-arginine N-methylation (GO:0035246)3.22907921
47chromatin assembly (GO:0031497)3.21389122
48regulation of gene silencing (GO:0060968)3.19122423
49regulation of helicase activity (GO:0051095)3.18371970
50Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.17476989
51regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.14660294
52protein localization to chromosome, centromeric region (GO:0071459)3.14284220
53mitotic metaphase plate congression (GO:0007080)3.13747608
54trophectodermal cell differentiation (GO:0001829)3.13321572
55regulation of histone H3-K9 methylation (GO:0051570)3.11284643
56regulation of nuclear cell cycle DNA replication (GO:0033262)3.10209185
57determination of adult lifespan (GO:0008340)3.06572933
58outer ear morphogenesis (GO:0042473)3.06183865
59regulation of sister chromatid cohesion (GO:0007063)3.04619680
60positive regulation of chromosome segregation (GO:0051984)3.03069787
61negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.02196839
62folic acid-containing compound biosynthetic process (GO:0009396)3.01927616
63spliceosomal tri-snRNP complex assembly (GO:0000244)3.00872890
64regulation of establishment of planar polarity (GO:0090175)3.00815166
65bone trabecula formation (GO:0060346)2.99378720
66negative regulation of chondrocyte differentiation (GO:0032331)2.95028773
67pore complex assembly (GO:0046931)2.92796604
68mitotic chromosome condensation (GO:0007076)2.91955856
69negative regulation of gene silencing (GO:0060969)2.90844174
70positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.89471161
71positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.89471161
72positive regulation of mitotic sister chromatid separation (GO:1901970)2.89471161
73regulation of SMAD protein import into nucleus (GO:0060390)2.88002951
74G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.86115033
75histone H2A monoubiquitination (GO:0035518)2.85549845
76DNA replication checkpoint (GO:0000076)2.84777522
77intracellular estrogen receptor signaling pathway (GO:0030520)2.84118605
78negative regulation of chromosome segregation (GO:0051985)2.81398245
79nodal signaling pathway (GO:0038092)2.80595286
80cochlea morphogenesis (GO:0090103)2.80081572
81cell migration in hindbrain (GO:0021535)2.78833293
82postsynaptic membrane organization (GO:0001941)2.77297500
83DNA strand elongation involved in DNA replication (GO:0006271)2.76639365
84regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.76419916
85negative regulation of mRNA processing (GO:0050686)2.75766568
86non-canonical Wnt signaling pathway (GO:0035567)2.74692834
87ribosome biogenesis (GO:0042254)2.74163318
88axon extension (GO:0048675)2.74033671
89replication fork processing (GO:0031297)2.73988038
90metaphase plate congression (GO:0051310)2.72963134
91maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.71654083
92IMP biosynthetic process (GO:0006188)2.70185407
93presynaptic membrane assembly (GO:0097105)2.70126900
94regulation of RNA export from nucleus (GO:0046831)2.68494504
95dosage compensation (GO:0007549)2.67483018
96planar cell polarity pathway involved in neural tube closure (GO:0090179)2.67277297
97nuclear envelope organization (GO:0006998)2.67126476
98embryonic process involved in female pregnancy (GO:0060136)2.66048475
99regulation of double-strand break repair (GO:2000779)2.65965452
100regulation of chromosome segregation (GO:0051983)2.65886576
101mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.64938848
102mRNA transport (GO:0051028)2.63815139
103negative regulation of telomerase activity (GO:0051974)2.62890194
104establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.60939820
105protein heterotrimerization (GO:0070208)2.60156630
106regulation of mitotic spindle organization (GO:0060236)2.59564485
107regulation of spindle organization (GO:0090224)2.59375201
108hippo signaling (GO:0035329)2.58849894
109DNA strand elongation (GO:0022616)2.58568654
110spindle assembly checkpoint (GO:0071173)2.58443685
111lateral sprouting from an epithelium (GO:0060601)2.58192654
112regulation of DNA damage checkpoint (GO:2000001)2.57990448
113establishment of tissue polarity (GO:0007164)2.57233756
114establishment of planar polarity (GO:0001736)2.57233756
115negative regulation of androgen receptor signaling pathway (GO:0060766)2.57222760
116mitotic sister chromatid cohesion (GO:0007064)2.56686257
117nucleobase biosynthetic process (GO:0046112)2.55376768
118mitotic spindle assembly checkpoint (GO:0007094)2.55290318
119negative regulation of mitotic sister chromatid separation (GO:2000816)2.55090041
120negative regulation of mitotic sister chromatid segregation (GO:0033048)2.55090041
121negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.55090041
122negative regulation of sister chromatid segregation (GO:0033046)2.55090041
123lung-associated mesenchyme development (GO:0060484)2.52566280
124ganglion development (GO:0061548)2.51066538
125regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.49973636
126chondrocyte proliferation (GO:0035988)2.49414916
127synaptic vesicle docking involved in exocytosis (GO:0016081)2.48687558
128regulation of axon guidance (GO:1902667)2.48291045
129regulation of axon extension involved in axon guidance (GO:0048841)2.47590702
130basement membrane organization (GO:0071711)2.44948813
131collagen fibril organization (GO:0030199)2.42571855
132atrial septum morphogenesis (GO:0060413)2.42448648
133protein retention in ER lumen (GO:0006621)2.41124835
134negative regulation of catenin import into nucleus (GO:0035414)2.40681052
135embryonic body morphogenesis (GO:0010172)2.38285272
136cell migration involved in sprouting angiogenesis (GO:0002042)2.36837142
137generation of neurons (GO:0048699)2.35173076
138neuron projection extension (GO:1990138)2.35068015
139negative regulation of axon guidance (GO:1902668)2.34342399
140establishment or maintenance of apical/basal cell polarity (GO:0035088)2.32641073
141establishment or maintenance of bipolar cell polarity (GO:0061245)2.32641073
142spinal cord development (GO:0021510)2.32407570
143apical protein localization (GO:0045176)2.32104352
144L-serine metabolic process (GO:0006563)2.30726317
145positive regulation of smoothened signaling pathway (GO:0045880)2.30357759
146maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.30149821
147negative regulation of axon extension involved in axon guidance (GO:0048843)2.30075461
148somatic stem cell division (GO:0048103)2.29963203
149body morphogenesis (GO:0010171)2.29799608
150semaphorin-plexin signaling pathway (GO:0071526)2.29300952
151establishment of integrated proviral latency (GO:0075713)2.28304220
152camera-type eye morphogenesis (GO:0048593)2.27968877
153branching involved in salivary gland morphogenesis (GO:0060445)2.27200954
154ventricular cardiac muscle cell development (GO:0055015)2.26315325
155neuron recognition (GO:0008038)2.23881092
156presynaptic membrane organization (GO:0097090)2.23270406
157dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.21415822
158adherens junction assembly (GO:0034333)2.20701895
159axonal fasciculation (GO:0007413)2.19803814
160lens fiber cell development (GO:0070307)2.19176741
161kidney mesenchyme development (GO:0072074)2.18496670
162regulation of cardioblast differentiation (GO:0051890)2.17616607
163neural tube development (GO:0021915)2.16448166
164regulation of catenin import into nucleus (GO:0035412)2.15608817
165negative regulation of embryonic development (GO:0045992)2.13917714
166cell surface receptor signaling pathway involved in heart development (GO:0061311)2.13228019
167craniofacial suture morphogenesis (GO:0097094)2.12303307
168positive regulation of cell cycle G2/M phase transition (GO:1902751)2.11703435
169positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.11703435
170peripheral nervous system axon ensheathment (GO:0032292)2.11279706
171myelination in peripheral nervous system (GO:0022011)2.11279706
172regulation of short-term neuronal synaptic plasticity (GO:0048172)2.10213435
173nucleosome disassembly (GO:0006337)2.09212530
174protein-DNA complex disassembly (GO:0032986)2.09212530
175negative regulation of cartilage development (GO:0061037)2.07729703
176layer formation in cerebral cortex (GO:0021819)2.07324241
177regulation of heart morphogenesis (GO:2000826)2.06566809
178regulation of NFAT protein import into nucleus (GO:0051532)2.05840914
179endothelial cell morphogenesis (GO:0001886)2.05307115
180NLS-bearing protein import into nucleus (GO:0006607)2.03680068
181dermatan sulfate biosynthetic process (GO:0030208)2.03264120
182regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.02658588
183mesenchymal to epithelial transition (GO:0060231)2.02653274

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.84557779
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.30999591
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.30999591
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.30999591
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.93943449
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.37201017
7SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.23325977
8SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.95750731
9* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.93532973
10* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.88987265
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.86236871
12NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.79029388
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.75376153
14* NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.75113519
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.70023051
16PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.59981044
17SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.59743794
18TCF3_18692474_ChIP-Seq_MEFs_Mouse2.59570335
19ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.50599337
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.45849318
21SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.45523139
22TCF3_18692474_ChIP-Seq_MESCs_Mouse2.42361445
23SALL1_21062744_ChIP-ChIP_HESCs_Human2.28958481
24KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.25926308
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.23357127
26WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.22610782
27NANOG_18555785_ChIP-Seq_MESCs_Mouse2.21617113
28SOX2_18555785_ChIP-Seq_MESCs_Mouse2.14603235
29EZH2_27304074_Chip-Seq_ESCs_Mouse2.07473618
30POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.06034334
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.03028644
32EED_16625203_ChIP-ChIP_MESCs_Mouse2.00693178
33TRIM28_21343339_ChIP-Seq_HEK293_Human2.00598208
34TP63_19390658_ChIP-ChIP_HaCaT_Human2.00268341
35NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.98145618
36STAT3_1855785_ChIP-Seq_MESCs_Mouse1.92160883
37* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.90378617
38MYC_18358816_ChIP-ChIP_MESCs_Mouse1.87735488
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.87695546
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.87147939
41EZH2_18974828_ChIP-Seq_MESCs_Mouse1.87147939
42* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.84765896
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.83676853
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.82670034
45CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.80545048
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.79496869
47KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.79337143
48* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.75216596
49NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.74533937
50SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.73550645
51ESR1_15608294_ChIP-ChIP_MCF-7_Human1.73470456
52NANOG_21062744_ChIP-ChIP_HESCs_Human1.71632647
53NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71146721
54NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.70789952
55HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.69847495
56EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.67166651
57* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.63605142
58RNF2_27304074_Chip-Seq_ESCs_Mouse1.62519767
59EGR1_19374776_ChIP-ChIP_THP-1_Human1.61024876
60TP53_20018659_ChIP-ChIP_R1E_Mouse1.60965429
61DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.60201934
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.59911527
63WT1_19549856_ChIP-ChIP_CCG9911_Human1.58260096
64EZH2_22144423_ChIP-Seq_EOC_Human1.58073788
65ERG_21242973_ChIP-ChIP_JURKAT_Human1.52287693
66* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.48904210
67* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.48900767
68* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.48826272
69XRN2_22483619_ChIP-Seq_HELA_Human1.47025029
70KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.46829177
71* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.45814993
72RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45335157
73ISL1_27105846_Chip-Seq_CPCs_Mouse1.45234196
74OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.44768398
75MYC_22102868_ChIP-Seq_BL_Human1.44203219
76JARID2_20064375_ChIP-Seq_MESCs_Mouse1.43995644
77KDM2B_26808549_Chip-Seq_K562_Human1.42845249
78RING1B_27294783_Chip-Seq_NPCs_Mouse1.41931568
79* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.38881063
80JARID2_20075857_ChIP-Seq_MESCs_Mouse1.38856988
81E2F1_21310950_ChIP-Seq_MCF-7_Human1.38545552
82AR_21909140_ChIP-Seq_LNCAP_Human1.38519159
83CBX2_27304074_Chip-Seq_ESCs_Mouse1.35531873
84KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34764180
85E2F1_18555785_ChIP-Seq_MESCs_Mouse1.33897910
86* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.33263577
87* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.32911661
88UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30848266
89RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.30136495
90P300_27058665_Chip-Seq_ZR-75-30cells_Human1.30090366
91* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.29750420
92* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.29082186
93SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.28344563
94DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.28021333
95TP63_17297297_ChIP-ChIP_HaCaT_Human1.27620338
96* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.27493328
97RING1B_27294783_Chip-Seq_ESCs_Mouse1.25830015
98HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.25238696
99SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.24560828
100SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.23400365
101GATA1_26923725_Chip-Seq_HPCs_Mouse1.22016343
102CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21906770
103SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.21080285
104THAP11_20581084_ChIP-Seq_MESCs_Mouse1.18389178
105EZH2_27294783_Chip-Seq_ESCs_Mouse1.17571780
106ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15747541
107CLOCK_20551151_ChIP-Seq_293T_Human1.14912629
108DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13243068
109EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12823034
110SUZ12_27294783_Chip-Seq_ESCs_Mouse1.12448857
111TTF2_22483619_ChIP-Seq_HELA_Human1.12004363
112* NANOG_16518401_ChIP-PET_MESCs_Mouse1.11692333
113ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11649893
114YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11347125
115TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11166634
116ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10470565
117CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08160691
118ETS1_20019798_ChIP-Seq_JURKAT_Human1.07992865
119* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.07766493
120YY1_21170310_ChIP-Seq_MESCs_Mouse1.06649018
121HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05089517
122TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03587059
123SOX2_16153702_ChIP-ChIP_HESCs_Human1.03009740
124KDM5A_27292631_Chip-Seq_BREAST_Human1.02923084
125ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02895258
126STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02279765
127EST1_17652178_ChIP-ChIP_JURKAT_Human1.02239426
128NANOG_16153702_ChIP-ChIP_HESCs_Human1.01253570
129CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.01207992
130TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01144569
131CTCF_27219007_Chip-Seq_Bcells_Human1.00904309
132SOX3_22085726_ChIP-Seq_NPCs_Mouse1.00130061
133TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99682550
134KAP1_27257070_Chip-Seq_ESCs_Mouse0.99260952
135EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98939164
136MTF2_20144788_ChIP-Seq_MESCs_Mouse0.98648622
137RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97155999
138RACK7_27058665_Chip-Seq_MCF-7_Human0.97033566
139ELK3_25401928_ChIP-Seq_HUVEC_Human0.96785153
140TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.96137423
141TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95880883
142CREB1_15753290_ChIP-ChIP_HEK293T_Human0.95554002
143POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95423497
144TET1_21490601_ChIP-Seq_MESCs_Mouse0.95342701
145NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.92546580
146EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.92262894
147ZNF263_19887448_ChIP-Seq_K562_Human0.89705147
148RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87762452
149GABP_19822575_ChIP-Seq_HepG2_Human0.86704660
150CIITA_25753668_ChIP-Seq_RAJI_Human0.84706987
151RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84418966

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.28398807
2MP0008057_abnormal_DNA_replication3.14281465
3MP0004957_abnormal_blastocyst_morpholog3.00572519
4MP0002653_abnormal_ependyma_morphology2.98634182
5MP0003111_abnormal_nucleus_morphology2.82160084
6MP0010030_abnormal_orbit_morphology2.79439237
7MP0010094_abnormal_chromosome_stability2.69542381
8MP0003123_paternal_imprinting2.53612800
9MP0003890_abnormal_embryonic-extraembry2.49339658
10MP0010352_gastrointestinal_tract_polyps2.47476949
11MP0003077_abnormal_cell_cycle2.42349740
12MP0004133_heterotaxia2.34745828
13MP0003705_abnormal_hypodermis_morpholog2.27850381
14MP0003119_abnormal_digestive_system2.22666722
15MP0003693_abnormal_embryo_hatching2.18653767
16MP0002084_abnormal_developmental_patter2.12650908
17MP0002085_abnormal_embryonic_tissue2.05321530
18MP0003283_abnormal_digestive_organ2.00702106
19MP0001730_embryonic_growth_arrest1.98381633
20MP0001672_abnormal_embryogenesis/_devel1.95355273
21MP0005380_embryogenesis_phenotype1.95355273
22MP0000350_abnormal_cell_proliferation1.94665657
23MP0003121_genomic_imprinting1.94367156
24MP0005503_abnormal_tendon_morphology1.93285927
25MP0001299_abnormal_eye_distance/1.92202269
26MP0004197_abnormal_fetal_growth/weight/1.90031194
27MP0003941_abnormal_skin_development1.86988694
28MP0001293_anophthalmia1.85791359
29MP0000566_synostosis1.85016057
30MP0000537_abnormal_urethra_morphology1.80648971
31MP0008932_abnormal_embryonic_tissue1.78064174
32MP0006292_abnormal_olfactory_placode1.76523836
33MP0001697_abnormal_embryo_size1.76390639
34MP0005171_absent_coat_pigmentation1.74734273
35MP0002086_abnormal_extraembryonic_tissu1.71700518
36MP0003984_embryonic_growth_retardation1.71686605
37MP0002088_abnormal_embryonic_growth/wei1.70290304
38MP0005076_abnormal_cell_differentiation1.70000957
39MP0004859_abnormal_synaptic_plasticity1.68361373
40MP0000778_abnormal_nervous_system1.65364688
41MP0008058_abnormal_DNA_repair1.64262981
42MP0002249_abnormal_larynx_morphology1.63476958
43MP0009053_abnormal_anal_canal1.58548522
44MP0009250_abnormal_appendicular_skeleto1.55110935
45MP0001849_ear_inflammation1.52059370
46MP0005623_abnormal_meninges_morphology1.51162096
47MP0003937_abnormal_limbs/digits/tail_de1.45374749
48MP0000579_abnormal_nail_morphology1.43818404
49MP0008007_abnormal_cellular_replicative1.43795505
50MP0003122_maternal_imprinting1.42413594
51MP0003755_abnormal_palate_morphology1.41629724
52MP0003567_abnormal_fetal_cardiomyocyte1.41331516
53MP0008877_abnormal_DNA_methylation1.40711939
54MP0004233_abnormal_muscle_weight1.39916503
55MP0002938_white_spotting1.39871789
56MP0002080_prenatal_lethality1.39155897
57MP0005275_abnormal_skin_tensile1.37592253
58MP0000049_abnormal_middle_ear1.34551373
59MP0003935_abnormal_craniofacial_develop1.33377576
60MP0005423_abnormal_somatic_nervous1.33199774
61MP0003861_abnormal_nervous_system1.32172394
62MP0000428_abnormal_craniofacial_morphol1.31117466
63MP0000432_abnormal_head_morphology1.26922604
64MP0002111_abnormal_tail_morphology1.26489081
65MP0001346_abnormal_lacrimal_gland1.24408951
66MP0003385_abnormal_body_wall1.23833066
67MP0003942_abnormal_urinary_system1.22319866
68MP0002932_abnormal_joint_morphology1.18650663
69MP0000462_abnormal_digestive_system1.16656595
70MP0004264_abnormal_extraembryonic_tissu1.16034207
71MP0005367_renal/urinary_system_phenotyp1.15160562
72MP0000516_abnormal_urinary_system1.15160562
73MP0002116_abnormal_craniofacial_bone1.14453530
74MP0002697_abnormal_eye_size1.14339755
75MP0003136_yellow_coat_color1.11711184
76MP0001286_abnormal_eye_development1.11323040
77MP0000534_abnormal_ureter_morphology1.11128060
78MP0003279_aneurysm1.10188707
79MP0009703_decreased_birth_body1.09605602
80MP0002092_abnormal_eye_morphology1.09315631
81MP0000751_myopathy1.09000315
82MP0000762_abnormal_tongue_morphology1.07127892
83MP0002114_abnormal_axial_skeleton1.06759390
84MP0010307_abnormal_tumor_latency1.06558907
85MP0003315_abnormal_perineum_morphology1.06146588
86MP0005499_abnormal_olfactory_system1.03811634
87MP0005394_taste/olfaction_phenotype1.03811634
88MP0009384_cardiac_valve_regurgitation1.03681141
89MP0002089_abnormal_postnatal_growth/wei1.03337266
90MP0002234_abnormal_pharynx_morphology1.03219444
91MP0003115_abnormal_respiratory_system1.02301314
92MP0002254_reproductive_system_inflammat1.02195893
93MP0003786_premature_aging1.01348853
94MP0010368_abnormal_lymphatic_system1.00049301
95MP0005197_abnormal_uvea_morphology1.00032091
96MP0002925_abnormal_cardiovascular_devel0.99461304
97MP0002233_abnormal_nose_morphology0.99307967
98MP0000678_abnormal_parathyroid_gland0.97654329
99MP0005187_abnormal_penis_morphology0.97029089
100MP0003566_abnormal_cell_adhesion0.95779375
101MP0009278_abnormal_bone_marrow0.95679096
102MP0002282_abnormal_trachea_morphology0.95645216
103MP0002751_abnormal_autonomic_nervous0.95055355
104MP0002177_abnormal_outer_ear0.93737086
105MP0003938_abnormal_ear_development0.93337118
106MP0005508_abnormal_skeleton_morphology0.89981137
107MP0004858_abnormal_nervous_system0.89499494
108MP0005257_abnormal_intraocular_pressure0.87444881
109MP0001958_emphysema0.86978481
110MP0002210_abnormal_sex_determination0.86769272
111MP0009780_abnormal_chondrocyte_physiolo0.86064841
112MP0000955_abnormal_spinal_cord0.85899284
113MP0002060_abnormal_skin_morphology0.85765477
114MP0001145_abnormal_male_reproductive0.85638680
115MP0002108_abnormal_muscle_morphology0.85097724
116MP0003787_abnormal_imprinting0.84100857
117MP0000767_abnormal_smooth_muscle0.83548995
118MP0002152_abnormal_brain_morphology0.83358394
119MP0000733_abnormal_muscle_development0.83211551
120MP0005248_abnormal_Harderian_gland0.82456695
121MP0008789_abnormal_olfactory_epithelium0.82129789
122MP0006072_abnormal_retinal_apoptosis0.81884777
123MP0002081_perinatal_lethality0.81080015
124MP0000467_abnormal_esophagus_morphology0.80930356
125MP0009672_abnormal_birth_weight0.80659112
126MP0000313_abnormal_cell_death0.79956402
127MP0002127_abnormal_cardiovascular_syste0.79914738
128MP0001188_hyperpigmentation0.79671644
129MP0001348_abnormal_lacrimal_gland0.79477102
130MP0005409_darkened_coat_color0.78815047
131MP0004270_analgesia0.77305897
132MP0002184_abnormal_innervation0.75621457
133MP0008770_decreased_survivor_rate0.75210375
134MP0001915_intracranial_hemorrhage0.74693915
135MP0001340_abnormal_eyelid_morphology0.74481542
136MP0004272_abnormal_basement_membrane0.73255275
137MP0003936_abnormal_reproductive_system0.72394998
138MP0002269_muscular_atrophy0.71542069

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.78953373
2Premature rupture of membranes (HP:0001788)4.29938726
3Abnormality of the astrocytes (HP:0100707)4.05744648
4Astrocytoma (HP:0009592)4.05744648
5Rib fusion (HP:0000902)3.77223007
6Abnormality of the labia minora (HP:0012880)3.42816745
7Medulloblastoma (HP:0002885)3.24507447
8Glioma (HP:0009733)3.20106897
9Neoplasm of the oral cavity (HP:0100649)3.15394354
10Abnormality of the lower motor neuron (HP:0002366)3.04749418
11Short humerus (HP:0005792)3.04667259
12Abnormality of dentin (HP:0010299)3.04587824
13Aplasia/hypoplasia of the humerus (HP:0006507)3.03729745
14Selective tooth agenesis (HP:0001592)3.02356758
15Supernumerary spleens (HP:0009799)2.98841807
16Rhabdomyosarcoma (HP:0002859)2.94971072
17Neoplasm of striated muscle (HP:0009728)2.87858523
18Coronal craniosynostosis (HP:0004440)2.84439659
19Turricephaly (HP:0000262)2.77907517
20Colon cancer (HP:0003003)2.75709138
21Missing ribs (HP:0000921)2.65970751
22Absent radius (HP:0003974)2.65100526
23Rectal fistula (HP:0100590)2.61670012
24Rectovaginal fistula (HP:0000143)2.61670012
25Bladder diverticulum (HP:0000015)2.59176589
26Broad metatarsal (HP:0001783)2.59144031
27Absent forearm bone (HP:0003953)2.54345105
28Aplasia involving forearm bones (HP:0009822)2.54345105
29Neonatal short-limb short stature (HP:0008921)2.54330663
30Soft skin (HP:0000977)2.51879673
31Facial hemangioma (HP:0000329)2.49750034
32Abnormal number of incisors (HP:0011064)2.41428181
33Renal duplication (HP:0000075)2.39653986
34Patellar aplasia (HP:0006443)2.38348825
35Bilateral microphthalmos (HP:0007633)2.35046188
36Intestinal fistula (HP:0100819)2.34917616
37Hyperacusis (HP:0010780)2.33518911
38Aplasia/Hypoplasia of the sternum (HP:0006714)2.31247802
39Bowel diverticulosis (HP:0005222)2.28721470
40Esophageal atresia (HP:0002032)2.28438449
41Atrophic scars (HP:0001075)2.27727714
42Supernumerary ribs (HP:0005815)2.25100423
43Abnormality of the salivary glands (HP:0010286)2.20358097
44Volvulus (HP:0002580)2.20015329
45Vascular tortuosity (HP:0004948)2.19890151
46Aplasia/Hypoplasia of the patella (HP:0006498)2.19250687
47Chromosomal breakage induced by crosslinking agents (HP:0003221)2.18708134
48Breast hypoplasia (HP:0003187)2.18107326
49Abnormality of abdominal situs (HP:0011620)2.18078790
50Abdominal situs inversus (HP:0003363)2.18078790
51Chromsome breakage (HP:0040012)2.16115344
52Hepatoblastoma (HP:0002884)2.15004089
53Vertebral fusion (HP:0002948)2.13763127
54Fused cervical vertebrae (HP:0002949)2.13303161
55Short 4th metacarpal (HP:0010044)2.12670351
56Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.12670351
57Supernumerary bones of the axial skeleton (HP:0009144)2.11984349
58Vaginal fistula (HP:0004320)2.11603524
59Increased nuchal translucency (HP:0010880)2.11299167
60Broad thumb (HP:0011304)2.09853692
61Nephroblastoma (Wilms tumor) (HP:0002667)2.09702556
62* Genu recurvatum (HP:0002816)2.07047743
63Arterial tortuosity (HP:0005116)2.06932348
64Proximal placement of thumb (HP:0009623)2.05482354
65Shallow orbits (HP:0000586)2.05431517
66Spinal rigidity (HP:0003306)2.05149605
67Abnormality of the aortic arch (HP:0012303)2.04742551
68Fragile skin (HP:0001030)2.04626004
69Deviation of the thumb (HP:0009603)2.03806169
70Short 1st metacarpal (HP:0010034)2.03160631
71Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.03160631
72Hypoventilation (HP:0002791)2.00544581
73Atresia of the external auditory canal (HP:0000413)1.99366704
74Aortic dissection (HP:0002647)1.99021411
75Broad alveolar ridges (HP:0000187)1.98783104
76Wide anterior fontanel (HP:0000260)1.97888096
77Hemivertebrae (HP:0002937)1.97813489
78Abnormality of the phalanges of the hallux (HP:0010057)1.97714232
79Embryonal renal neoplasm (HP:0011794)1.96338473
80Morphological abnormality of the middle ear (HP:0008609)1.96013363
81Cervical subluxation (HP:0003308)1.95341953
82Hypochromic microcytic anemia (HP:0004840)1.93829018
83Abnormality of the ileum (HP:0001549)1.93669603
84Disproportionate tall stature (HP:0001519)1.93529840
85Aplasia involving bones of the extremities (HP:0009825)1.91902223
86Aplasia involving bones of the upper limbs (HP:0009823)1.91902223
87Aplasia of the phalanges of the hand (HP:0009802)1.91902223
88Broad long bones (HP:0005622)1.91121339
89Thin ribs (HP:0000883)1.90934582
90Anophthalmia (HP:0000528)1.90811068
91Biconcave vertebral bodies (HP:0004586)1.89576082
92Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.86954263
93Malignant gastrointestinal tract tumors (HP:0006749)1.86916353
94Gastrointestinal carcinoma (HP:0002672)1.86916353
95* Shawl scrotum (HP:0000049)1.86842408
96Partial duplication of the phalanx of hand (HP:0009999)1.86822605
97Short phalanx of the thumb (HP:0009660)1.86784767
98Deviation of the hallux (HP:0010051)1.86775982
99Gastrointestinal atresia (HP:0002589)1.86473332
100Overriding aorta (HP:0002623)1.86289762
101Abnormality of the calcaneus (HP:0008364)1.85969755
102Pseudobulbar signs (HP:0002200)1.85226354
103Cutaneous finger syndactyly (HP:0010554)1.84065324
104Arnold-Chiari malformation (HP:0002308)1.83952243
105Trigonocephaly (HP:0000243)1.83518382
106Mitral valve prolapse (HP:0001634)1.83016917
107Meckel diverticulum (HP:0002245)1.82636034
108* High anterior hairline (HP:0009890)1.81058139
109Impulsivity (HP:0100710)1.80810771
110Agnosia (HP:0010524)1.80729879
111Birth length less than 3rd percentile (HP:0003561)1.80585743
112Calcaneovalgus deformity (HP:0001848)1.80417123
113Angiofibromas (HP:0010615)1.79694424
114Adenoma sebaceum (HP:0009720)1.79694424
115Joint laxity (HP:0001388)1.79314771
116Cutaneous syndactyly (HP:0012725)1.78607002
117Wormian bones (HP:0002645)1.77679613
118Broad finger (HP:0001500)1.77146990
119Vitreoretinal degeneration (HP:0000655)1.77117746
120Broad phalanx (HP:0006009)1.76830485
121Deformed tarsal bones (HP:0008119)1.75898595
122Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.75766453
123Absent epiphyses (HP:0010577)1.75766453
124Vertebral clefting (HP:0008428)1.75701146
125Choanal stenosis (HP:0000452)1.75253159
126Broad phalanges of the hand (HP:0009768)1.75191151
127Hallux valgus (HP:0001822)1.74491105
128Abnormality of the 4th metacarpal (HP:0010012)1.73991161
129Preaxial foot polydactyly (HP:0001841)1.73960444
130Absent thumb (HP:0009777)1.73635088
131Spinal muscular atrophy (HP:0007269)1.73047367
132Basal cell carcinoma (HP:0002671)1.72606288
133Trismus (HP:0000211)1.72369649
134Partial duplication of thumb phalanx (HP:0009944)1.71731465
135Protrusio acetabuli (HP:0003179)1.71307486
136Abnormality of the 1st metacarpal (HP:0010009)1.69698724
137Blue sclerae (HP:0000592)1.69676361
138Vertebral hypoplasia (HP:0008417)1.68453710
139Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.68453710
140Abnormal lung lobation (HP:0002101)1.68307441
141Ankle contracture (HP:0006466)1.68159789
142Insomnia (HP:0100785)1.67769166
143Heterotopia (HP:0002282)1.67472426
144Abnormality of the diencephalon (HP:0010662)1.66874121
145Preauricular skin tag (HP:0000384)1.66645246
146Aplasia/Hypoplasia of the uvula (HP:0010293)1.66516439
147Concave nail (HP:0001598)1.66276123
148Obstructive sleep apnea (HP:0002870)1.66190083
149Ulnar bowing (HP:0003031)1.65465418
150Short 5th finger (HP:0009237)1.65415751
151Broad distal phalanx of finger (HP:0009836)1.65186477
152Skin tags (HP:0010609)1.65015632
153Malignant neoplasm of the central nervous system (HP:0100836)1.64967720
154Fibroma (HP:0010614)1.64958609
155Amyotrophic lateral sclerosis (HP:0007354)1.64121843
156Benign neoplasm of the central nervous system (HP:0100835)1.63349496
157Vertebral arch anomaly (HP:0008438)1.63296667
158Midface retrusion (HP:0011800)1.60424971
159Wrist flexion contracture (HP:0001239)1.60349001
160Cortical dysplasia (HP:0002539)1.60014096
161Abnormality of the distal phalanx of the thumb (HP:0009617)1.58943659
162Bronchomalacia (HP:0002780)1.58649316
163Protruding ear (HP:0000411)1.58574409
164Abnormality of the middle phalanges of the toes (HP:0010183)1.57571729
165Mitral regurgitation (HP:0001653)1.56753773
166Pterygium (HP:0001059)1.55635479
167Cerebral aneurysm (HP:0004944)1.54824718
168Upper limb amyotrophy (HP:0009129)1.53992604
169Distal upper limb amyotrophy (HP:0007149)1.53992604
170Natal tooth (HP:0000695)1.53393973
171Aqueductal stenosis (HP:0002410)1.52930062
172* Hyperextensible skin (HP:0000974)1.50120254
173Long palpebral fissure (HP:0000637)1.49953167
174Hypoplasia of the capital femoral epiphysis (HP:0003090)1.49125136
175Infantile muscular hypotonia (HP:0008947)1.47427130
176Overgrowth (HP:0001548)1.46591340
177Breech presentation (HP:0001623)1.45796253
178Midline defect of the nose (HP:0004122)1.45180256
179Elfin facies (HP:0004428)1.44913292
180Hand muscle atrophy (HP:0009130)1.44373734
181Duplication of thumb phalanx (HP:0009942)1.43557263
182Aortic aneurysm (HP:0004942)1.43414998
183Follicular hyperkeratosis (HP:0007502)1.42053377

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.39935915
2CDC73.15679274
3LATS22.98122966
4ICK2.71365956
5EPHA22.62292901
6TTK2.60134004
7NTRK12.52957465
8NEK12.45255415
9WEE12.41494748
10TYRO32.34649840
11CASK2.28158361
12DDR22.25481287
13LATS12.14583374
14CDK72.06294290
15NEK21.97782946
16VRK21.84065691
17FGFR21.81669906
18CHEK21.76106276
19PLK11.75267612
20BUB11.73424259
21PDGFRA1.69173215
22AKT31.66808149
23SMG11.66110111
24MAP3K101.65012735
25RPS6KB21.59424352
26PNCK1.47356558
27BRD41.44118914
28EEF2K1.38696796
29MTOR1.32810170
30STK38L1.29049265
31CHEK11.26679352
32TSSK61.23306757
33ALK1.22618331
34PKN21.17763801
35ATR1.14868923
36BMX1.10771042
37TNIK1.09717824
38EPHA41.07018037
39MAP3K61.06307370
40NTRK21.05287329
41AURKA1.04800593
42PAK41.03849953
43CDK21.03686002
44CDK41.03064821
45PLK31.02387286
46LIMK11.02204473
47AURKB1.01756176
48MATK1.01155072
49PASK0.97993957
50SIK10.96348565
51ATM0.96272177
52DYRK20.95903553
53DMPK0.95694396
54TAOK20.93875247
55LMTK20.93715953
56CAMK1G0.93632615
57WNK30.93404643
58MAP3K90.93229819
59TAF10.92240735
60MAP3K80.89771843
61SRPK10.89079284
62MKNK10.83616425
63PRKCI0.82446197
64CSNK1G10.80162739
65STK100.78391381
66DYRK30.78071666
67RIPK10.77565301
68CSNK1G30.75925047
69CDK10.75891481
70CSNK1E0.75004652
71TGFBR10.74898756
72TESK20.74584843
73CDK60.74307338
74ROCK20.74257770
75FGFR10.73589994
76AKT20.73199794
77ACVR1B0.72454255
78RPS6KA20.72296711
79CSNK1G20.71889066
80MET0.69215313
81TESK10.68813127
82CSNK1A1L0.67735264
83PAK60.67584155
84PBK0.67170287
85KSR10.67093375
86TRIB30.66628077
87CDK140.66047440
88PLK20.64433275
89PTK20.63626519
90UHMK10.63438178
91SCYL20.63167826
92PRKD30.63068514
93STK30.62709940
94PAK20.61983166
95MKNK20.59060657
96STK160.58881348
97GRK50.58880666
98CSNK1D0.58174530
99CDC42BPA0.57912244
100PDGFRB0.57318688
101PLK40.57318141
102MARK10.56276885
103MELK0.54443725
104ROCK10.53563798
105PAK10.53427713
106CAMK1D0.52464627
107FLT30.52341221
108ERBB40.50970767
109FGR0.50614035
110PRKDC0.50423489
111GSK3B0.49910769
112MAPK140.49242963
113GRK60.48167331
114PHKG20.48011350
115PHKG10.48011350
116CDK80.47991830
117TTN0.47749302
118CLK10.46450365
119MAPK10.46261825
120NTRK30.45289017
121DYRK1B0.45272335
122MAPK100.44990424
123BCR0.44517107
124ILK0.44250084
125MINK10.43062938
126CSNK2A20.41836595
127BRSK20.41483281
128AKT10.41264641
129EPHB20.39977011
130STK380.39325521
131CDK11A0.38906808
132CDK150.38433287
133BRSK10.37256894
134RPS6KA10.35691988
135DAPK10.35637755
136PRKD20.34965492
137CDK180.34694076
138KSR20.34385192
139STK40.33309464

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.93982021
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.52670232
3DNA replication_Homo sapiens_hsa030303.47460226
4RNA transport_Homo sapiens_hsa030133.28066673
5Spliceosome_Homo sapiens_hsa030402.87321113
6Cell cycle_Homo sapiens_hsa041102.64048906
7mRNA surveillance pathway_Homo sapiens_hsa030152.61884720
8Base excision repair_Homo sapiens_hsa034102.57864946
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.50812649
10One carbon pool by folate_Homo sapiens_hsa006702.39220441
11Nucleotide excision repair_Homo sapiens_hsa034202.20589552
12Basal cell carcinoma_Homo sapiens_hsa052172.20416459
13Hippo signaling pathway_Homo sapiens_hsa043902.14385153
14Homologous recombination_Homo sapiens_hsa034402.10039871
15Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.04089426
16Hedgehog signaling pathway_Homo sapiens_hsa043401.97092225
17Fanconi anemia pathway_Homo sapiens_hsa034601.97014788
18Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.78102552
19RNA polymerase_Homo sapiens_hsa030201.59432044
20Adherens junction_Homo sapiens_hsa045201.57419896
21MicroRNAs in cancer_Homo sapiens_hsa052061.55660693
22Oocyte meiosis_Homo sapiens_hsa041141.54246421
23p53 signaling pathway_Homo sapiens_hsa041151.53912313
24RNA degradation_Homo sapiens_hsa030181.53003206
25mTOR signaling pathway_Homo sapiens_hsa041501.52930859
26Notch signaling pathway_Homo sapiens_hsa043301.50972763
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.45901317
28TGF-beta signaling pathway_Homo sapiens_hsa043501.40459339
29Ribosome_Homo sapiens_hsa030101.34451285
30Basal transcription factors_Homo sapiens_hsa030221.28652859
31Bladder cancer_Homo sapiens_hsa052191.27297156
32Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.26811929
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.24321400
34Wnt signaling pathway_Homo sapiens_hsa043101.24300481
35Tight junction_Homo sapiens_hsa045301.23928099
36Colorectal cancer_Homo sapiens_hsa052101.19091916
37Non-homologous end-joining_Homo sapiens_hsa034501.16717152
38Thyroid cancer_Homo sapiens_hsa052161.12452219
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.10419140
40Biosynthesis of amino acids_Homo sapiens_hsa012301.05724638
41Protein digestion and absorption_Homo sapiens_hsa049741.05675213
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05349962
43Central carbon metabolism in cancer_Homo sapiens_hsa052301.04369182
44Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93861554
45Sulfur relay system_Homo sapiens_hsa041220.93521820
46Lysine degradation_Homo sapiens_hsa003100.92994244
47Endometrial cancer_Homo sapiens_hsa052130.90555148
48Cocaine addiction_Homo sapiens_hsa050300.88680905
49Pyrimidine metabolism_Homo sapiens_hsa002400.88578231
50Pathways in cancer_Homo sapiens_hsa052000.86350344
51Proteoglycans in cancer_Homo sapiens_hsa052050.86215607
52HTLV-I infection_Homo sapiens_hsa051660.83066573
53Viral carcinogenesis_Homo sapiens_hsa052030.82498515
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.82435972
55Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81955101
56Nicotine addiction_Homo sapiens_hsa050330.79868915
57Melanoma_Homo sapiens_hsa052180.79491261
58N-Glycan biosynthesis_Homo sapiens_hsa005100.77107786
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75780328
60Small cell lung cancer_Homo sapiens_hsa052220.75607208
61Folate biosynthesis_Homo sapiens_hsa007900.74856566
62Fructose and mannose metabolism_Homo sapiens_hsa000510.74069790
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73281523
64Focal adhesion_Homo sapiens_hsa045100.72892517
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69926646
66Dopaminergic synapse_Homo sapiens_hsa047280.69526568
67Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.68999380
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68324324
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66796897
70* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65470483
71Vibrio cholerae infection_Homo sapiens_hsa051100.65360479
72Prion diseases_Homo sapiens_hsa050200.63016606
73Dorso-ventral axis formation_Homo sapiens_hsa043200.62478730
74Prostate cancer_Homo sapiens_hsa052150.62065989
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61962735
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61120815
77Selenocompound metabolism_Homo sapiens_hsa004500.60865779
78Steroid biosynthesis_Homo sapiens_hsa001000.60559363
79Glutamatergic synapse_Homo sapiens_hsa047240.60528653
80Melanogenesis_Homo sapiens_hsa049160.59086508
81ECM-receptor interaction_Homo sapiens_hsa045120.58773282
82Fatty acid biosynthesis_Homo sapiens_hsa000610.58150340
83PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57461916
84Gap junction_Homo sapiens_hsa045400.57342175
85Insulin secretion_Homo sapiens_hsa049110.57209151
86Circadian entrainment_Homo sapiens_hsa047130.57190760
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56875678
88AMPK signaling pathway_Homo sapiens_hsa041520.56727723
89Epstein-Barr virus infection_Homo sapiens_hsa051690.56395831
90Rap1 signaling pathway_Homo sapiens_hsa040150.56213848
91Glucagon signaling pathway_Homo sapiens_hsa049220.55717842
92ErbB signaling pathway_Homo sapiens_hsa040120.55682313
93Synaptic vesicle cycle_Homo sapiens_hsa047210.54546791
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54494530
95Proteasome_Homo sapiens_hsa030500.53126224
96Amphetamine addiction_Homo sapiens_hsa050310.52503817
97Chronic myeloid leukemia_Homo sapiens_hsa052200.52421197
98Cholinergic synapse_Homo sapiens_hsa047250.51330556
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51258296
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51088178
101Axon guidance_Homo sapiens_hsa043600.50954103
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.50483670
103Glioma_Homo sapiens_hsa052140.49783199
104Amoebiasis_Homo sapiens_hsa051460.49364473
105Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48551213
106Renal cell carcinoma_Homo sapiens_hsa052110.48440332
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48349991
108Thyroid hormone synthesis_Homo sapiens_hsa049180.48055959
109cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47647301
110Vitamin B6 metabolism_Homo sapiens_hsa007500.47118767
111Non-small cell lung cancer_Homo sapiens_hsa052230.46579347
112Estrogen signaling pathway_Homo sapiens_hsa049150.45645049
113HIF-1 signaling pathway_Homo sapiens_hsa040660.43888348
114Viral myocarditis_Homo sapiens_hsa054160.42454668
115Choline metabolism in cancer_Homo sapiens_hsa052310.41539320
116VEGF signaling pathway_Homo sapiens_hsa043700.41509293
117Galactose metabolism_Homo sapiens_hsa000520.39121364
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37919707
119Alcoholism_Homo sapiens_hsa050340.37763435
120Cysteine and methionine metabolism_Homo sapiens_hsa002700.36541383
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36422313
122Dilated cardiomyopathy_Homo sapiens_hsa054140.33992816
123Insulin signaling pathway_Homo sapiens_hsa049100.32911918
124MAPK signaling pathway_Homo sapiens_hsa040100.32380618
125Purine metabolism_Homo sapiens_hsa002300.31787246
126Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31367878
127Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30473955
128GnRH signaling pathway_Homo sapiens_hsa049120.30407711
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28419035
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.27435256
131Systemic lupus erythematosus_Homo sapiens_hsa053220.27273318

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »