FGD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.18802780
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.84460920
3negative regulation of cell killing (GO:0031342)5.84460920
4detection of other organism (GO:0098543)4.86759862
5detection of bacterium (GO:0016045)4.79663132
6regulation of gamma-delta T cell differentiation (GO:0045586)4.60401383
7regulation of B cell receptor signaling pathway (GO:0050855)4.58687900
8positive regulation by symbiont of host defense response (GO:0052509)4.56270448
9modulation by symbiont of host defense response (GO:0052031)4.56270448
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.56270448
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.56270448
12positive regulation by organism of defense response of other organism involved in symbiotic interact4.56270448
13modulation by symbiont of host immune response (GO:0052553)4.56270448
14negative regulation of lymphocyte mediated immunity (GO:0002707)4.53879006
15regulation of gamma-delta T cell activation (GO:0046643)4.49944378
16positive thymic T cell selection (GO:0045059)4.29596194
17B cell receptor signaling pathway (GO:0050853)4.27575384
18leukocyte aggregation (GO:0070486)4.14997705
19neutrophil activation involved in immune response (GO:0002283)4.13905793
20negative regulation of leukocyte mediated immunity (GO:0002704)4.01318815
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.00538442
22detection of external biotic stimulus (GO:0098581)3.97380140
23regulation of interferon-beta biosynthetic process (GO:0045357)3.96364557
24negative regulation of T cell mediated immunity (GO:0002710)3.96224603
25antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.82927743
26antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.82927743
27negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.77693453
28macrophage activation involved in immune response (GO:0002281)3.75884254
29positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.74578818
30antigen processing and presentation of endogenous antigen (GO:0019883)3.73619955
31leukocyte migration involved in inflammatory response (GO:0002523)3.69494211
32positive regulation of B cell differentiation (GO:0045579)3.65908196
33negative thymic T cell selection (GO:0045060)3.62785866
34response to muramyl dipeptide (GO:0032495)3.59103807
35negative T cell selection (GO:0043383)3.56042829
36regulation of mast cell degranulation (GO:0043304)3.51146444
37type I interferon signaling pathway (GO:0060337)3.50902768
38cellular response to type I interferon (GO:0071357)3.50902768
39regulation of B cell differentiation (GO:0045577)3.50026939
40response to type I interferon (GO:0034340)3.48617732
41regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.46370320
42regulation of natural killer cell mediated immunity (GO:0002715)3.46370320
43detection of biotic stimulus (GO:0009595)3.45800451
44regulation of tolerance induction (GO:0002643)3.45772566
45detection of molecule of bacterial origin (GO:0032490)3.45273953
46antigen processing and presentation via MHC class Ib (GO:0002475)3.44194716
47leukocyte cell-cell adhesion (GO:0007159)3.43942557
48negative regulation of interleukin-12 production (GO:0032695)3.43062229
49neutrophil activation (GO:0042119)3.41945326
50regulation of T cell mediated cytotoxicity (GO:0001914)3.39207618
51cell adhesion mediated by integrin (GO:0033627)3.36565447
52regulation of interleukin-12 biosynthetic process (GO:0045075)3.35264144
53positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.34502828
54respiratory burst (GO:0045730)3.34106059
55microglial cell activation (GO:0001774)3.33469435
56regulation of dendritic cell antigen processing and presentation (GO:0002604)3.32800923
57positive T cell selection (GO:0043368)3.31864477
58positive regulation of T cell mediated cytotoxicity (GO:0001916)3.31714594
59tolerance induction (GO:0002507)3.28577194
60granulocyte activation (GO:0036230)3.26524363
61leukocyte degranulation (GO:0043299)3.23819237
62thymic T cell selection (GO:0045061)3.23419738
63regulation of myeloid leukocyte mediated immunity (GO:0002886)3.23217719
64regulation of mast cell activation involved in immune response (GO:0033006)3.22444586
65regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.21125022
66negative regulation of erythrocyte differentiation (GO:0045647)3.21021797
67regulation of regulatory T cell differentiation (GO:0045589)3.18064679
68positive regulation of mast cell activation (GO:0033005)3.16451813
69response to peptidoglycan (GO:0032494)3.14206682
70production of molecular mediator involved in inflammatory response (GO:0002532)3.14180741
71negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.13554903
72negative regulation of T-helper cell differentiation (GO:0045623)3.13554903
73myeloid cell activation involved in immune response (GO:0002275)3.13267187
74negative regulation of innate immune response (GO:0045824)3.12622955
75T cell migration (GO:0072678)3.12097703
76NIK/NF-kappaB signaling (GO:0038061)3.11622115
77positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.10943665
78cellular extravasation (GO:0045123)3.10760863
79response to host (GO:0075136)3.10616082
80response to host defenses (GO:0052200)3.10616082
81response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.10616082
82response to laminar fluid shear stress (GO:0034616)3.10483926
83heterotypic cell-cell adhesion (GO:0034113)3.10322440
84regulation of leukocyte degranulation (GO:0043300)3.10134750
85macrophage activation (GO:0042116)3.09902000
86positive regulation of granulocyte differentiation (GO:0030854)3.06995462
87T cell selection (GO:0045058)3.05424294
88regulation of mast cell activation (GO:0033003)3.03209290
89B cell mediated immunity (GO:0019724)3.02621664
90response to host immune response (GO:0052572)3.02485514
91response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.02485514
92negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.01495175
93positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.01226308
94substrate-dependent cell migration (GO:0006929)3.00913410
95germinal center formation (GO:0002467)2.99307675
96positive regulation of tolerance induction (GO:0002645)2.98858117
97negative regulation of alpha-beta T cell activation (GO:0046636)2.96892203
98response to interleukin-15 (GO:0070672)2.94376324
99positive regulation of interferon-alpha production (GO:0032727)2.92567182
100cortical actin cytoskeleton organization (GO:0030866)2.92347314
101positive regulation of antigen processing and presentation (GO:0002579)2.91864485
102B cell homeostasis (GO:0001782)2.91355369
103mature B cell differentiation (GO:0002335)2.90542548
104regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.90173720
105antigen receptor-mediated signaling pathway (GO:0050851)2.88585335
106regulation of antigen processing and presentation (GO:0002577)2.88300965
107regulation of interferon-alpha production (GO:0032647)2.86980363
108immunoglobulin mediated immune response (GO:0016064)2.82559134
109neutrophil mediated immunity (GO:0002446)2.81522752
110I-kappaB phosphorylation (GO:0007252)2.80764177
111negative regulation of phagocytosis (GO:0050765)2.78729809
112negative regulation of B cell proliferation (GO:0030889)2.76882155
113positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.75857918
114pinocytosis (GO:0006907)2.75028193
115positive regulation of macrophage differentiation (GO:0045651)2.64905393
116negative regulation of interleukin-6 production (GO:0032715)2.62925398
117regulation of alpha-beta T cell proliferation (GO:0046640)2.61149438
118JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.58416465
119response to protozoan (GO:0001562)2.57885459
120positive regulation of isotype switching (GO:0045830)2.57725562
121T cell costimulation (GO:0031295)2.56837891
122cortical cytoskeleton organization (GO:0030865)2.56365070
123T cell receptor signaling pathway (GO:0050852)2.56176100
124immune response-activating cell surface receptor signaling pathway (GO:0002429)2.55910597
125lymphocyte homeostasis (GO:0002260)2.55685186
126regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.54488206
127interferon-gamma production (GO:0032609)2.54227344
128integrin-mediated signaling pathway (GO:0007229)2.53647779
129B cell proliferation (GO:0042100)2.53551767
130cellular response to interleukin-15 (GO:0071350)2.53284498
131regulation of T cell tolerance induction (GO:0002664)2.51974941
132interferon-gamma-mediated signaling pathway (GO:0060333)2.51633755
133negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.51445811
134lymphocyte costimulation (GO:0031294)2.51012716
135germ cell migration (GO:0008354)2.50997498
136modulation by symbiont of host cellular process (GO:0044068)2.50692477
137activated T cell proliferation (GO:0050798)2.50593421
138myeloid leukocyte activation (GO:0002274)2.50134279
139Arp2/3 complex-mediated actin nucleation (GO:0034314)2.49159010
140positive regulation of cell adhesion mediated by integrin (GO:0033630)2.47709289
141defense response to protozoan (GO:0042832)2.47213930

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.09328040
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.14497168
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.10481713
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.95223546
5* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.53623799
6* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.40052633
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.38878390
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.34292857
9* IRF8_27001747_Chip-Seq_BMDM_Mouse3.33694212
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.04797109
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.93705369
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.91619678
13VDR_21846776_ChIP-Seq_THP-1_Human2.90058141
14MYC_22102868_ChIP-Seq_BL_Human2.83833063
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.77026453
16RUNX_20019798_ChIP-Seq_JUKART_Human2.64720280
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.60681060
18FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.57015608
19SCL_19346495_ChIP-Seq_HPC-7_Human2.54829841
20* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.51232199
21* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.38969514
22MYB_26560356_Chip-Seq_TH2_Human2.35246513
23MAF_26560356_Chip-Seq_TH1_Human2.34691163
24VDR_24763502_ChIP-Seq_THP-1_Human2.32912055
25* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.25886602
26* TCF7_22412390_ChIP-Seq_EML_Mouse2.23613397
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.23605527
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.17108649
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.15980890
30UTX_26944678_Chip-Seq_JUKART_Human2.15692565
31STAT4_19710469_ChIP-ChIP_TH1__Mouse2.12810708
32* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.11470019
33SPI1_23127762_ChIP-Seq_K562_Human2.11300251
34* RUNX1_22412390_ChIP-Seq_EML_Mouse2.11266811
35MYB_26560356_Chip-Seq_TH1_Human2.07981119
36SPI1_23547873_ChIP-Seq_NB4_Human2.07443873
37RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.06987561
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.05048430
39KDM2B_26808549_Chip-Seq_SUP-B15_Human2.01856658
40KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.97162876
41KDM2B_26808549_Chip-Seq_DND41_Human1.94139976
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.92205809
43ELK3_25401928_ChIP-Seq_HUVEC_Human1.89481507
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.85558007
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.78387193
46NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.69157082
47* PU_27001747_Chip-Seq_BMDM_Mouse1.59814794
48PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.55429304
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.52806545
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.48501073
51GATA3_27048872_Chip-Seq_THYMUS_Human1.47476572
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.44723185
53MAF_26560356_Chip-Seq_TH2_Human1.44137138
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40856103
55TP63_17297297_ChIP-ChIP_HaCaT_Human1.39514428
56RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.38972268
57PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32546897
58GATA2_21666600_ChIP-Seq_HMVEC_Human1.31874573
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.31166829
60FOXM1_23109430_ChIP-Seq_U2OS_Human1.29354746
61CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29290797
62* VDR_24787735_ChIP-Seq_THP-1_Human1.28411898
63TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26003142
64BCL6_27268052_Chip-Seq_Bcells_Human1.25637084
65KDM2B_26808549_Chip-Seq_JURKAT_Human1.23475698
66FOXO3_23340844_ChIP-Seq_DLD1_Human1.23267278
67* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22895176
68PU.1_20513432_ChIP-Seq_Bcells_Mouse1.20771129
69CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19485305
70KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17703957
71SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.17177396
72GATA1_19941826_ChIP-Seq_K562_Human1.16870999
73STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16730536
74* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16018866
75RARG_19884340_ChIP-ChIP_MEFs_Mouse1.14682283
76CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13702939
77BCOR_27268052_Chip-Seq_Bcells_Human1.13296070
78VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.13103214
79IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13084649
80RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.12286221
81THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.12072866
82CIITA_25753668_ChIP-Seq_RAJI_Human1.08768254
83LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.07778437
84GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07468519
85SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05998418
86NCOR1_26117541_ChIP-Seq_K562_Human1.05877958
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05429488
88GATA2_19941826_ChIP-Seq_K562_Human1.03928955
89SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03868641
90* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.02704420
91* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.02704420
92CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02493414
93GATA1_19941827_ChIP-Seq_MEL_Mouse1.01675563
94LXR_22292898_ChIP-Seq_THP-1_Human1.01608807
95P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01239186
96PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00673604
97RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99629983
98GATA3_26560356_Chip-Seq_TH2_Human0.97475437
99PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95328967
100CTCF_27219007_Chip-Seq_ERYTHROID_Human0.95295828
101TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95294665
102KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94402442
103ELF1_20517297_ChIP-Seq_JURKAT_Human0.94388943
104ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93346427
105* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92024002
106SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.91929369
107TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91570144
108SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90339654
109SMAD_19615063_ChIP-ChIP_OVARY_Human0.89930875
110SPI1_20517297_ChIP-Seq_HL60_Human0.88434438
111FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.87551605
112SA1_27219007_Chip-Seq_ERYTHROID_Human0.87147109
113CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85454807
114* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.85451960
115GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.84674903
116LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.83894061
117* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83744744
118ESR2_21235772_ChIP-Seq_MCF-7_Human0.83320973
119P68_20966046_ChIP-Seq_HELA_Human0.82419697

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.67531357
2MP0001835_abnormal_antigen_presentation3.22268726
3MP0003300_gastrointestinal_ulcer3.13212428
4MP0003436_decreased_susceptibility_to2.95465283
5MP0000685_abnormal_immune_system2.93260372
6MP0000569_abnormal_digit_pigmentation2.91496690
7MP0001790_abnormal_immune_system2.87655494
8MP0005387_immune_system_phenotype2.87655494
9MP0001800_abnormal_humoral_immune2.83763046
10MP0005000_abnormal_immune_tolerance2.66714948
11MP0002452_abnormal_antigen_presenting2.63913161
12MP0002419_abnormal_innate_immunity2.59010502
13MP0005058_abnormal_lysosome_morphology2.48599994
14MP0002723_abnormal_immune_serum2.41618018
15MP0005671_abnormal_response_to2.40122523
16MP0009278_abnormal_bone_marrow2.37745521
17MP0002420_abnormal_adaptive_immunity2.36643000
18MP0005464_abnormal_platelet_physiology2.36486571
19MP0001819_abnormal_immune_cell2.34615308
20MP0005025_abnormal_response_to2.27441323
21MP0009785_altered_susceptibility_to2.21716936
22MP0003172_abnormal_lysosome_physiology2.21346931
23MP0006082_CNS_inflammation2.16308158
24MP0004947_skin_inflammation2.07613674
25MP0002405_respiratory_system_inflammati2.06080761
26MP0003566_abnormal_cell_adhesion2.04463489
27MP0002398_abnormal_bone_marrow2.02829355
28MP0004510_myositis1.99949098
29MP0003763_abnormal_thymus_physiology1.93341616
30MP0008260_abnormal_autophagy1.93220609
31MP0010352_gastrointestinal_tract_polyps1.93203911
32MP0000716_abnormal_immune_system1.89708920
33MP0000689_abnormal_spleen_morphology1.79415423
34MP0002148_abnormal_hypersensitivity_rea1.78670496
35MP0001533_abnormal_skeleton_physiology1.78040796
36MP0002166_altered_tumor_susceptibility1.76996081
37MP0009333_abnormal_splenocyte_physiolog1.76879312
38MP0002132_abnormal_respiratory_system1.76693212
39MP0002933_joint_inflammation1.74287907
40MP0004808_abnormal_hematopoietic_stem1.72552640
41MP0002396_abnormal_hematopoietic_system1.70019055
42MP0000465_gastrointestinal_hemorrhage1.68812837
43MP0003091_abnormal_cell_migration1.68591265
44MP0002722_abnormal_immune_system1.65105944
45MP0003448_altered_tumor_morphology1.61373712
46MP0010155_abnormal_intestine_physiology1.61343819
47MP0001845_abnormal_inflammatory_respons1.60997057
48MP0004381_abnormal_hair_follicle1.60678717
49MP0002277_abnormal_respiratory_mucosa1.55985995
50MP0001853_heart_inflammation1.55966720
51MP0002429_abnormal_blood_cell1.54285817
52MP0005023_abnormal_wound_healing1.53222508
53MP0001873_stomach_inflammation1.51431683
54MP0000858_altered_metastatic_potential1.49249705
55MP0002006_tumorigenesis1.40770505
56MP0000703_abnormal_thymus_morphology1.40331013
57MP0005174_abnormal_tail_pigmentation1.40011325
58MP0005397_hematopoietic_system_phenotyp1.39977248
59MP0001545_abnormal_hematopoietic_system1.39977248
60MP0002998_abnormal_bone_remodeling1.36638201
61MP0003279_aneurysm1.34398145
62MP0003045_fibrosis1.32858102
63MP0001851_eye_inflammation1.29020068
64MP0004883_abnormal_blood_vessel1.26820610
65MP0003183_abnormal_peptide_metabolism1.25310373
66MP0001958_emphysema1.24013167
67MP0005451_abnormal_body_composition1.22515815
68MP0005076_abnormal_cell_differentiation1.21508443
69MP0008438_abnormal_cutaneous_collagen1.18973904
70MP0003724_increased_susceptibility_to1.16499980
71MP0001986_abnormal_taste_sensitivity1.15830878
72MP0000604_amyloidosis1.13134615
73MP0003866_abnormal_defecation1.09500607
74MP0008469_abnormal_protein_level1.08732704
75MP0005075_abnormal_melanosome_morpholog1.07615870
76MP0000733_abnormal_muscle_development1.07031131
77MP0010307_abnormal_tumor_latency1.06199568
78MP0003453_abnormal_keratinocyte_physiol0.99689634
79MP0002928_abnormal_bile_duct0.99601269
80MP0000490_abnormal_crypts_of0.96471462
81MP0003705_abnormal_hypodermis_morpholog0.95656480
82MP0000015_abnormal_ear_pigmentation0.95549712
83MP0009840_abnormal_foam_cell0.93095897
84MP0005390_skeleton_phenotype0.92533591
85MP0000920_abnormal_myelination0.90437550
86MP0006054_spinal_hemorrhage0.90204765
87MP0003075_altered_response_to0.89943104
88MP0001663_abnormal_digestive_system0.88849565
89MP0000343_altered_response_to0.86337211
90MP0005310_abnormal_salivary_gland0.86217690
91MP0005164_abnormal_response_to0.85785161
92MP0003191_abnormal_cellular_cholesterol0.85509730
93MP0005166_decreased_susceptibility_to0.82836888
94MP0000767_abnormal_smooth_muscle0.79614152
95MP0001348_abnormal_lacrimal_gland0.79246635
96MP0002138_abnormal_hepatobiliary_system0.79017319
97MP0000249_abnormal_blood_vessel0.78783200
98MP0003795_abnormal_bone_structure0.78714309
99MP0005623_abnormal_meninges_morphology0.74760223
100MP0005621_abnormal_cell_physiology0.73491694
101MP0001243_abnormal_dermal_layer0.72749600
102MP0002877_abnormal_melanocyte_morpholog0.70479249
103MP0009764_decreased_sensitivity_to0.70303761
104MP0001915_intracranial_hemorrhage0.70238074
105MP0004130_abnormal_muscle_cell0.69737833
106MP0009765_abnormal_xenobiotic_induced0.68082958
107MP0008004_abnormal_stomach_pH0.67672959
108MP0002019_abnormal_tumor_incidence0.67623093
109MP0005167_abnormal_blood-brain_barrier0.67152435
110MP0003690_abnormal_glial_cell0.64860854
111MP0002009_preneoplasia0.64822618
112MP0003828_pulmonary_edema0.64306374
113MP0009763_increased_sensitivity_to0.63430900
114MP0003656_abnormal_erythrocyte_physiolo0.63025916
115MP0002136_abnormal_kidney_physiology0.61266715
116MP0003221_abnormal_cardiomyocyte_apopto0.60278837
117MP0008874_decreased_physiological_sensi0.59303528
118MP0002168_other_aberrant_phenotype0.58601401
119MP0002693_abnormal_pancreas_physiology0.49766698
120MP0005377_hearing/vestibular/ear_phenot0.48847917
121MP0003878_abnormal_ear_physiology0.48847917
122MP0003806_abnormal_nucleotide_metabolis0.47554404
123MP0005381_digestive/alimentary_phenotyp0.46828739
124MP0002133_abnormal_respiratory_system0.44738391
125MP0005388_respiratory_system_phenotype0.44738391
126MP0005319_abnormal_enzyme/_coenzyme0.43799053

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.00195717
2Recurrent bacterial skin infections (HP:0005406)4.53201854
3Eczematoid dermatitis (HP:0000976)4.42980416
4Gastrointestinal infarctions (HP:0005244)4.27849833
5Encephalitis (HP:0002383)3.96282359
6Increased IgE level (HP:0003212)3.72016915
7Hypochromic microcytic anemia (HP:0004840)3.67303323
8Keratoconjunctivitis sicca (HP:0001097)3.61234857
9Recurrent fungal infections (HP:0002841)3.49891425
10Cellulitis (HP:0100658)3.48459634
11Recurrent viral infections (HP:0004429)3.44088644
12Hypochromic anemia (HP:0001931)3.43451716
13Keratoconjunctivitis (HP:0001096)3.39391124
14Urticaria (HP:0001025)3.38481133
15Stomatitis (HP:0010280)3.31982038
16Elevated erythrocyte sedimentation rate (HP:0003565)3.23640910
17Myositis (HP:0100614)3.22836791
18Increased cerebral lipofuscin (HP:0011813)3.18895758
19Recurrent skin infections (HP:0001581)3.13373395
20Abnormality of macrophages (HP:0004311)3.11609747
21Hemoptysis (HP:0002105)3.01463936
22Granulocytopenia (HP:0001913)2.97921373
23T lymphocytopenia (HP:0005403)2.94942216
24Increased IgM level (HP:0003496)2.94478607
25Mediastinal lymphadenopathy (HP:0100721)2.91821274
26Increased density of long bones (HP:0006392)2.91086126
27Episodic fever (HP:0001954)2.88198394
28Chronic obstructive pulmonary disease (HP:0006510)2.88074131
29Obstructive lung disease (HP:0006536)2.88074131
30Inflammation of the large intestine (HP:0002037)2.87131033
31Abnormality of T cell number (HP:0011839)2.84375248
32Colitis (HP:0002583)2.81196667
33Vacuolated lymphocytes (HP:0001922)2.80990020
34Cerebral aneurysm (HP:0004944)2.78075963
35Pustule (HP:0200039)2.75499502
36Increased neuronal autofluorescent lipopigment (HP:0002074)2.75335986
37Recurrent gram-negative bacterial infections (HP:0005420)2.74022289
38Gastrointestinal inflammation (HP:0004386)2.74011048
39Abnormal delayed hypersensitivity skin test (HP:0002963)2.71379498
40Meningitis (HP:0001287)2.71179946
41Abnormality of T cell physiology (HP:0011840)2.68331412
42IgM deficiency (HP:0002850)2.68167768
43Abnormal platelet volume (HP:0011876)2.67587152
44Anorexia (HP:0002039)2.67214936
45Chronic otitis media (HP:0000389)2.66948114
46Pulmonary embolism (HP:0002204)2.65525200
47Agammaglobulinemia (HP:0004432)2.63994753
48Vasculitis (HP:0002633)2.63590402
49Recurrent cutaneous fungal infections (HP:0011370)2.63180082
50Chronic mucocutaneous candidiasis (HP:0002728)2.63180082
51Orchitis (HP:0100796)2.60349801
52Periodontitis (HP:0000704)2.59818657
53Gingivitis (HP:0000230)2.59319323
54Osteolytic defects of the phalanges of the hand (HP:0009771)2.56904515
55Osteolytic defects of the hand bones (HP:0009699)2.56904515
56Recurrent bronchitis (HP:0002837)2.55817272
57Petechiae (HP:0000967)2.55078985
58Interstitial pulmonary disease (HP:0006530)2.54941409
59Autoimmune thrombocytopenia (HP:0001973)2.53557268
60Aortic aneurysm (HP:0004942)2.52831998
61Absent frontal sinuses (HP:0002688)2.49524455
62Microcytic anemia (HP:0001935)2.48772403
63Optic neuritis (HP:0100653)2.48139063
64Retrobulbar optic neuritis (HP:0100654)2.48139063
65Osteomyelitis (HP:0002754)2.47953291
66Panhypogammaglobulinemia (HP:0003139)2.47615674
67Sepsis (HP:0100806)2.45572224
68Leukocytosis (HP:0001974)2.44233517
69Pulmonary infiltrates (HP:0002113)2.40688791
70Hypergammaglobulinemia (HP:0010702)2.38740941
71Increased mean platelet volume (HP:0011877)2.38676141
72Peritonitis (HP:0002586)2.37905922
73Aortic dissection (HP:0002647)2.36591893
74Thyroiditis (HP:0100646)2.33800902
75Abnormality of the pleura (HP:0002103)2.33531355
76Spondylolisthesis (HP:0003302)2.32574976
77Dysostosis multiplex (HP:0000943)2.29776798
78Abnormality of eosinophils (HP:0001879)2.29717507
79Persistence of primary teeth (HP:0006335)2.29109953
80Arterial tortuosity (HP:0005116)2.27117959
81Restrictive lung disease (HP:0002091)2.26914889
82Severe combined immunodeficiency (HP:0004430)2.24455827
83Premature rupture of membranes (HP:0001788)2.22377593
84Ulnar bowing (HP:0003031)2.21284967
85Papilloma (HP:0012740)2.21074377
86Verrucae (HP:0200043)2.21074377
87Gangrene (HP:0100758)2.20782541
88Disinhibition (HP:0000734)2.19466355
89Abnormality of liposaccharide metabolism (HP:0010968)2.18158131
90Abnormality of glycosphingolipid metabolism (HP:0004343)2.18158131
91Abnormality of glycolipid metabolism (HP:0010969)2.18158131
92Autoimmune hemolytic anemia (HP:0001890)2.16136235
93Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.15611183
94Abnormality of T cells (HP:0002843)2.15462682
95Prolonged bleeding time (HP:0003010)2.15321119
96Myocardial infarction (HP:0001658)2.14425974
97Nasal polyposis (HP:0100582)2.12562407
98Purpura (HP:0000979)2.11950976
99Lymphopenia (HP:0001888)2.11934038
100Vascular tortuosity (HP:0004948)2.11564808
101Hematochezia (HP:0002573)2.11497268
102Dilatation of the ascending aorta (HP:0005111)2.11276614
103Emphysema (HP:0002097)2.11241285
104Arterial thrombosis (HP:0004420)2.10893620
105Slow saccadic eye movements (HP:0000514)2.09893920
106IgG deficiency (HP:0004315)2.09344398
107Papilledema (HP:0001085)2.09173226
108Gastrointestinal stroma tumor (HP:0100723)2.08748879
109Glomerulopathy (HP:0100820)2.06352713
110Keratitis (HP:0000491)2.06256441
111Acute hepatic failure (HP:0006554)2.05851201
112Abnormality of cells of the lymphoid lineage (HP:0012140)2.04739817
113Recurrent sinusitis (HP:0011108)2.04103262
114Axonal loss (HP:0003447)2.04021306
115Syringomyelia (HP:0003396)2.04004712
116Spinal cord lesions (HP:0100561)2.04004712
117Epistaxis (HP:0000421)2.02755306
118Amyloidosis (HP:0011034)2.02726549
119Abnormality of the peritoneum (HP:0002585)2.02171440
120Abnormal platelet function (HP:0011869)2.00926083
121Impaired platelet aggregation (HP:0003540)2.00926083
122Premature loss of primary teeth (HP:0006323)2.00133690
123Spontaneous hematomas (HP:0007420)1.99861366
124Thrombocytosis (HP:0001894)1.99717669
125Eosinophilia (HP:0001880)1.99402685
126Viral hepatitis (HP:0006562)1.99035027
127Abnormality of the endocardium (HP:0004306)1.97940519
128Broad face (HP:0000283)1.95170551
129Frequent falls (HP:0002359)1.94531713
130Gingival bleeding (HP:0000225)1.94184650
131Mitral valve prolapse (HP:0001634)1.94136267
132Abnormality of the fingertips (HP:0001211)1.94062834
133Increased serum ferritin (HP:0003281)1.93408956
134Joint swelling (HP:0001386)1.93100628
135Chest pain (HP:0100749)1.93051603
136Hepatosplenomegaly (HP:0001433)1.92303429
137Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.90265515
138Acne (HP:0001061)1.89113092
139Vertigo (HP:0002321)1.88246143
140Abnormality of iron homeostasis (HP:0011031)1.87370451
141Abnormality of the pericardium (HP:0001697)1.85776823
142Skin ulcer (HP:0200042)1.83597560
143Fatigue (HP:0012378)1.82083671
144Thick nail (HP:0001805)1.81844937
145Menorrhagia (HP:0000132)1.81364050

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.33598548
2TTN2.92170839
3STK102.50622844
4MAP3K142.45742569
5EPHB12.33933534
6PRPF4B2.28343574
7TYK22.21780953
8TRIB32.21098076
9TXK2.09566284
10TBK12.09560366
11JAK32.07537923
12BLK2.04151300
13MAP3K102.02176136
14RIPK42.00482783
15ITK1.91838571
16GRK61.87700252
17TGFBR21.84464285
18LRRK21.82267133
19HCK1.82236744
20EEF2K1.81098489
21ERN11.78770241
22KIT1.77090691
23JAK11.76834795
24CSF1R1.76228701
25IRAK41.75384704
26ZAP701.75312500
27CSK1.72569399
28BTK1.71933469
29PKN21.71420757
30SIK21.71265685
31IRAK31.62401977
32IKBKE1.59249582
33SIK31.56688784
34MAP3K131.56408932
35MAP3K111.53244446
36MAP3K31.49581689
37FES1.44482235
38SYK1.44188106
39TRPM71.41126552
40IKBKB1.39298395
41PTK61.39235936
42LCK1.38408319
43CAMK1D1.34145184
44CLK11.28346515
45CAMK1G1.26973470
46CDK121.15354630
47FGR1.12848935
48MAP2K31.09023715
49MAP3K11.05962958
50TEC1.02264909
51TAOK31.01957009
52KSR21.01909413
53RPS6KA40.97315331
54MARK30.96245248
55LYN0.93607608
56FGFR40.92614676
57YES10.91016351
58CDK190.88343857
59ALK0.88080429
60PIM10.87377468
61FGFR30.86863415
62PRKCH0.80148949
63BMX0.79380201
64IRAK10.77433455
65JAK20.77016044
66TESK20.75732698
67CHUK0.75681432
68PAK40.75568165
69RIPK10.72507053
70MAP3K60.71331965
71PDGFRB0.71199595
72MST40.70605744
73BMPR20.69453365
74DYRK1B0.69262642
75SMG10.69245407
76PRKCQ0.69094086
77TAOK20.68213147
78EGFR0.67781969
79PTK20.66159799
80CAMKK10.65597085
81PAK20.64413652
82DMPK0.64180157
83NLK0.61683058
84CAMKK20.61387853
85IRAK20.60171427
86CDC42BPA0.59269436
87ABL10.58787708
88MAPK70.58615384
89MAP3K80.58212224
90FYN0.58064690
91STK110.56326576
92MAP2K40.55074624
93MELK0.54383139
94CDK60.53548643
95STK380.51997099
96TNK20.51707980
97MARK20.50684850
98PDK10.49399222
99INSR0.49369263
100MAPKAPK20.49150121
101NEK90.48992101
102STK40.48859126
103PTK2B0.48842532
104MAP3K70.48544021
105RPS6KC10.46616403
106RPS6KL10.46616403
107MTOR0.46514962
108RET0.45138155
109MAP2K20.43646937
110EPHA30.42663305
111SGK30.40857685
112MATK0.40702636
113MAP3K50.40096500
114MOS0.39450815
115CDK90.38088184
116PRKD10.37902373
117RPS6KA60.37475139
118GRK70.37346749
119PDPK10.36940968
120SRC0.36331499
121TAOK10.36190645
122PIK3CG0.35278390
123PDGFRA0.35067071
124CDK40.34917161
125PRKG20.34610149
126MAP2K60.34333775
127PKN10.33626800
128HIPK20.33625872
129RAF10.33344355
130PRKD20.33161915
131PASK0.32472099
132SIK10.32348782
133MAPK120.32113965
134SCYL20.31508835
135MAP3K20.29685837
136MAPK110.28008427
137SGK20.26970152

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046622.79009362
2Leishmaniasis_Homo sapiens_hsa051402.63859893
3Osteoclast differentiation_Homo sapiens_hsa043802.51654897
4Primary immunodeficiency_Homo sapiens_hsa053402.41072166
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.15063062
6Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.10189034
7Type I diabetes mellitus_Homo sapiens_hsa049401.99498670
8Hematopoietic cell lineage_Homo sapiens_hsa046401.87807175
9T cell receptor signaling pathway_Homo sapiens_hsa046601.87511531
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.85588301
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.79338000
12Measles_Homo sapiens_hsa051621.77365146
13Leukocyte transendothelial migration_Homo sapiens_hsa046701.77139445
14Staphylococcus aureus infection_Homo sapiens_hsa051501.74854164
15Shigellosis_Homo sapiens_hsa051311.73351980
16Malaria_Homo sapiens_hsa051441.69191378
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.69003843
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.62325238
19Chronic myeloid leukemia_Homo sapiens_hsa052201.60058375
20Toxoplasmosis_Homo sapiens_hsa051451.59726755
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.59300003
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.58993189
23Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.56570237
24Tuberculosis_Homo sapiens_hsa051521.54408195
25Pertussis_Homo sapiens_hsa051331.51628942
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.50547683
27Chemokine signaling pathway_Homo sapiens_hsa040621.46216363
28Pancreatic cancer_Homo sapiens_hsa052121.45209263
29TNF signaling pathway_Homo sapiens_hsa046681.44560409
30Platelet activation_Homo sapiens_hsa046111.41217021
31Antigen processing and presentation_Homo sapiens_hsa046121.40891952
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.39068848
33Apoptosis_Homo sapiens_hsa042101.36163198
34Lysosome_Homo sapiens_hsa041421.35097676
35Hepatitis B_Homo sapiens_hsa051611.30935702
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.29708437
37Salmonella infection_Homo sapiens_hsa051321.29422603
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.27910183
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.25599488
40Other glycan degradation_Homo sapiens_hsa005111.25452473
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.25086073
42Acute myeloid leukemia_Homo sapiens_hsa052211.23521201
43Influenza A_Homo sapiens_hsa051641.19075934
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.14597626
45Small cell lung cancer_Homo sapiens_hsa052221.14388446
46Viral myocarditis_Homo sapiens_hsa054161.13906103
47Neurotrophin signaling pathway_Homo sapiens_hsa047221.10301153
48Graft-versus-host disease_Homo sapiens_hsa053321.07630042
49* Regulation of actin cytoskeleton_Homo sapiens_hsa048101.04085970
50Proteoglycans in cancer_Homo sapiens_hsa052051.02921987
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02153330
52Legionellosis_Homo sapiens_hsa051341.01889728
53Allograft rejection_Homo sapiens_hsa053301.01144995
54Herpes simplex infection_Homo sapiens_hsa051680.99904349
55VEGF signaling pathway_Homo sapiens_hsa043700.99245803
56Focal adhesion_Homo sapiens_hsa045100.98876120
57Amoebiasis_Homo sapiens_hsa051460.98347418
58Phagosome_Homo sapiens_hsa041450.98084263
59Non-small cell lung cancer_Homo sapiens_hsa052230.96211475
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94931337
61Asthma_Homo sapiens_hsa053100.91659838
62MicroRNAs in cancer_Homo sapiens_hsa052060.90635803
63Renal cell carcinoma_Homo sapiens_hsa052110.89937297
64Hepatitis C_Homo sapiens_hsa051600.88834226
65Rheumatoid arthritis_Homo sapiens_hsa053230.86454305
66Viral carcinogenesis_Homo sapiens_hsa052030.83921594
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82708514
68HTLV-I infection_Homo sapiens_hsa051660.81819144
69Endocytosis_Homo sapiens_hsa041440.81696422
70Colorectal cancer_Homo sapiens_hsa052100.81147494
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.79733124
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76221085
73Prolactin signaling pathway_Homo sapiens_hsa049170.73906488
74Epstein-Barr virus infection_Homo sapiens_hsa051690.71535862
75Glioma_Homo sapiens_hsa052140.69518371
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69287628
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69134768
78Endometrial cancer_Homo sapiens_hsa052130.66966726
79ECM-receptor interaction_Homo sapiens_hsa045120.66888372
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66831385
81MAPK signaling pathway_Homo sapiens_hsa040100.66157679
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.66100523
83Rap1 signaling pathway_Homo sapiens_hsa040150.65844173
84FoxO signaling pathway_Homo sapiens_hsa040680.65056374
85Regulation of autophagy_Homo sapiens_hsa041400.64435044
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64291623
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62654825
88mTOR signaling pathway_Homo sapiens_hsa041500.60972461
89Notch signaling pathway_Homo sapiens_hsa043300.60019199
90Prostate cancer_Homo sapiens_hsa052150.58058588
91HIF-1 signaling pathway_Homo sapiens_hsa040660.57201936
92Inositol phosphate metabolism_Homo sapiens_hsa005620.56712221
93Bladder cancer_Homo sapiens_hsa052190.55960586
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55062992
95p53 signaling pathway_Homo sapiens_hsa041150.52696253
96Caffeine metabolism_Homo sapiens_hsa002320.52131508
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52127713
98Adherens junction_Homo sapiens_hsa045200.51300228
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50907342
100GnRH signaling pathway_Homo sapiens_hsa049120.50872619
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50854669
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48900988
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.48805175
104Pathways in cancer_Homo sapiens_hsa052000.48355059
105African trypanosomiasis_Homo sapiens_hsa051430.48110625
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47600409
107Dorso-ventral axis formation_Homo sapiens_hsa043200.45480242
108Autoimmune thyroid disease_Homo sapiens_hsa053200.45111125
109Insulin resistance_Homo sapiens_hsa049310.44524289
110Choline metabolism in cancer_Homo sapiens_hsa052310.44506932
111Type II diabetes mellitus_Homo sapiens_hsa049300.43632824
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.43549604
113ErbB signaling pathway_Homo sapiens_hsa040120.38511457
114Ras signaling pathway_Homo sapiens_hsa040140.31055137

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »