ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sperm motility (GO:0030317)	5.08287254
2	protein polyglutamylation (GO:0018095)	4.89902541
3	behavioral response to nicotine (GO:0035095)	4.76040659
4	seminiferous tubule development (GO:0072520)	4.67579762
5	response to pheromone (GO:0019236)	4.55503635
6	establishment of protein localization to Golgi (GO:0072600)	4.46149476
7	regulation of cilium movement (GO:0003352)	4.45019406
8	protein targeting to Golgi (GO:0000042)	4.32565184
9	piRNA metabolic process (GO:0034587)	4.31637035
10	acrosome reaction (GO:0007340)	4.25091560
11	L-fucose metabolic process (GO:0042354)	4.18649318
12	L-fucose catabolic process (GO:0042355)	4.18649318
13	fucose catabolic process (GO:0019317)	4.18649318
14	RNA destabilization (GO:0050779)	4.10576411
15	axoneme assembly (GO:0035082)	4.09545778
16	cellular ketone body metabolic process (GO:0046950)	4.01372545
17	epithelial cilium movement (GO:0003351)	3.99334375
18	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.90467433
19	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.74930279
20	multicellular organism reproduction (GO:0032504)	3.68797267
21	cilium or flagellum-dependent cell motility (GO:0001539)	3.66205968
22	fusion of sperm to egg plasma membrane (GO:0007342)	3.65053708
23	DNA methylation involved in gamete generation (GO:0043046)	3.61587593
24	ketone body metabolic process (GO:1902224)	3.59760867
25	protein localization to Golgi apparatus (GO:0034067)	3.58790187
26	centriole replication (GO:0007099)	3.55028953
27	cell wall macromolecule catabolic process (GO:0016998)	3.50051381
28	indolalkylamine catabolic process (GO:0046218)	3.45823143
29	tryptophan catabolic process (GO:0006569)	3.45823143
30	indole-containing compound catabolic process (GO:0042436)	3.45823143
31	detection of light stimulus involved in sensory perception (GO:0050962)	3.34014147
32	detection of light stimulus involved in visual perception (GO:0050908)	3.34014147
33	spermatid development (GO:0007286)	3.32786155
34	single strand break repair (GO:0000012)	3.32603810
35	indolalkylamine metabolic process (GO:0006586)	3.32064900
36	cilium movement (GO:0003341)	3.22299724
37	nonmotile primary cilium assembly (GO:0035058)	3.14135313
38	rRNA catabolic process (GO:0016075)	3.14012545
39	axonemal dynein complex assembly (GO:0070286)	3.09574971
40	regulation of microtubule-based movement (GO:0060632)	3.09158577
41	cell wall macromolecule metabolic process (GO:0044036)	3.07676503
42	negative regulation of telomere maintenance (GO:0032205)	3.03926502
43	kynurenine metabolic process (GO:0070189)	3.02321252
44	fucosylation (GO:0036065)	3.01626346
45	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.01294176
46	pyrimidine nucleobase catabolic process (GO:0006208)	2.99300321
47	plasma membrane fusion (GO:0045026)	2.95125258
48	calcium ion-dependent exocytosis (GO:0017156)	2.94907258
49	regulation of meiosis I (GO:0060631)	2.94838090
50	microtubule depolymerization (GO:0007019)	2.93058719
51	cilium organization (GO:0044782)	2.91450766
52	preassembly of GPI anchor in ER membrane (GO:0016254)	2.90109535
53	water-soluble vitamin biosynthetic process (GO:0042364)	2.90016310
54	cilium morphogenesis (GO:0060271)	2.87187490
55	regulation of action potential (GO:0098900)	2.85797777
56	photoreceptor cell maintenance (GO:0045494)	2.85557830
57	rRNA methylation (GO:0031167)	2.85361791
58	rRNA modification (GO:0000154)	2.83837919
59	cilium assembly (GO:0042384)	2.83017275
60	synaptic transmission, cholinergic (GO:0007271)	2.79409294
61	phosphatidylethanolamine metabolic process (GO:0046337)	2.77451755
62	microtubule severing (GO:0051013)	2.77228625
63	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.76552752
64	male meiosis I (GO:0007141)	2.76055857
65	tryptophan metabolic process (GO:0006568)	2.74603847
66	DNA deamination (GO:0045006)	2.74083412
67	sperm-egg recognition (GO:0035036)	2.71540676
68	protein localization to cilium (GO:0061512)	2.70433780
69	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.70049389
70	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.70049389
71	nucleobase catabolic process (GO:0046113)	2.68361840
72	male meiosis (GO:0007140)	2.67073148
73	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.66624817
74	spermatogenesis (GO:0007283)	2.65182193
75	ubiquinone biosynthetic process (GO:0006744)	2.65065935
76	male gamete generation (GO:0048232)	2.64757373
77	behavioral response to ethanol (GO:0048149)	2.63755622
78	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.63408194
79	indole-containing compound metabolic process (GO:0042430)	2.62504354
80	positive regulation of mitochondrial fission (GO:0090141)	2.61414549
81	signal peptide processing (GO:0006465)	2.60417095
82	somite development (GO:0061053)	2.59697260
83	photoreceptor cell development (GO:0042461)	2.59649420
84	L-methionine salvage (GO:0071267)	2.58781367
85	L-methionine biosynthetic process (GO:0071265)	2.58781367
86	amino acid salvage (GO:0043102)	2.58781367
87	negative regulation of cAMP-mediated signaling (GO:0043951)	2.57023237
88	reproduction (GO:0000003)	2.56692348
89	cellular biogenic amine catabolic process (GO:0042402)	2.56421415
90	amine catabolic process (GO:0009310)	2.56421415
91	ubiquinone metabolic process (GO:0006743)	2.53839748
92	neuronal action potential (GO:0019228)	2.53074632
93	gamma-aminobutyric acid transport (GO:0015812)	2.52703095
94	centriole assembly (GO:0098534)	2.52479259
95	microtubule polymerization or depolymerization (GO:0031109)	2.52398106
96	coenzyme catabolic process (GO:0009109)	2.52112897
97	retinal cone cell development (GO:0046549)	2.51929012
98	C4-dicarboxylate transport (GO:0015740)	2.51098385
99	nephron tubule morphogenesis (GO:0072078)	2.50741226
100	nephron epithelium morphogenesis (GO:0072088)	2.50741226

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.96799401
2	VDR_22108803_ChIP-Seq_LS180_Human	3.35305045
3	EZH2_22144423_ChIP-Seq_EOC_Human	2.89672299
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.51134575
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.46690915
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.35982585
7	FUS_26573619_Chip-Seq_HEK293_Human	2.27469809
8	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.26208172
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.24632205
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.12100066
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.11879452
12	ER_23166858_ChIP-Seq_MCF-7_Human	2.02596005
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.99140548
14	P300_19829295_ChIP-Seq_ESCs_Human	1.97305257
15	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.91025264
16	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.88494693
17	CBP_20019798_ChIP-Seq_JUKART_Human	1.88494693
18	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.85133519
19	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.83274076
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.70858397
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.70625032
22	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.66950054
23	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.66785597
24	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.66785597
25	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.66299826
26	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.62179424
27	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.61677227
28	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.61584978
29	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.56451288
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.55830987
31	IRF1_19129219_ChIP-ChIP_H3396_Human	1.53516867
32	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.51942441
33	REST_21632747_ChIP-Seq_MESCs_Mouse	1.51325785
34	EWS_26573619_Chip-Seq_HEK293_Human	1.50742701
35	STAT3_23295773_ChIP-Seq_U87_Human	1.46984760
36	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.44329746
37	AR_25329375_ChIP-Seq_VCAP_Human	1.44017459
38	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.43078314
39	SOX2_19829295_ChIP-Seq_ESCs_Human	1.42740629
40	NANOG_19829295_ChIP-Seq_ESCs_Human	1.42740629
41	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.39969997
42	SMAD4_21799915_ChIP-Seq_A2780_Human	1.39174700
43	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.38823572
44	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.37697604
45	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.34905947
46	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.34905947
47	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.34672444
48	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.33878526
49	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.32920390
50	TCF4_22108803_ChIP-Seq_LS180_Human	1.32537505
51	TCF4_23295773_ChIP-Seq_U87_Human	1.32287371
52	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.32263395
53	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.31836398
54	AR_21572438_ChIP-Seq_LNCaP_Human	1.31424103
55	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.30180608
56	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.29365100
57	RUNX2_22187159_ChIP-Seq_PCA_Human	1.28537350
58	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.28086245
59	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.26991934
60	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.26884333
61	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.26273723
62	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.26211874
63	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.26064035
64	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.25173163
65	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.24983961
66	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.24447409
67	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.23761178
68	NCOR_22424771_ChIP-Seq_293T_Human	1.21736104
69	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.20150028
70	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.18240470
71	HOXB7_26014856_ChIP-Seq_BT474_Human	1.18216158
72	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.17155372
73	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.16503007
74	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.16162949
75	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.15766376
76	AR_20517297_ChIP-Seq_VCAP_Human	1.15105915
77	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.14710240
78	BCAT_22108803_ChIP-Seq_LS180_Human	1.14547957
79	TAF2_19829295_ChIP-Seq_ESCs_Human	1.13449470
80	MYC_19829295_ChIP-Seq_ESCs_Human	1.11027105
81	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08792488
82	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.07507635
83	CDX2_22108803_ChIP-Seq_LS180_Human	1.07114041
84	ETV1_20927104_ChIP-Seq_GIST48_Human	1.06947580
85	ERA_21632823_ChIP-Seq_H3396_Human	1.06382174
86	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.05624593
87	NANOG_20526341_ChIP-Seq_ESCs_Human	1.05444581
88	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.05073023
89	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.04286162
90	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.02697088
91	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.02216045
92	RBPJ_21746931_ChIP-Seq_IB4_Human	1.01501157
93	PHF8_20622853_ChIP-Seq_HELA_Human	1.00500420
94	RNF2_27304074_Chip-Seq_NSC_Mouse	1.00195326
95	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.98258025
96	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.96948332
97	RAC3_21632823_ChIP-Seq_H3396_Human	0.96912797
98	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.96552545
99	NFYB_21822215_ChIP-Seq_K562_Human	0.96505693
100	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.94848021

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.28507898
2	MP0003787_abnormal_imprinting	3.21214983
3	MP0005410_abnormal_fertilization	2.95151414
4	MP0002102_abnormal_ear_morphology	2.76284063
5	MP0005377_hearing/vestibular/ear_phenot	2.56226100
6	MP0003878_abnormal_ear_physiology	2.56226100
7	MP0001968_abnormal_touch/_nociception	2.50728998
8	MP0005551_abnormal_eye_electrophysiolog	2.47161184
9	MP0002837_dystrophic_cardiac_calcinosis	2.18895335
10	MP0001984_abnormal_olfaction	2.17478018
11	MP0003646_muscle_fatigue	2.03909432
12	MP0001986_abnormal_taste_sensitivity	2.01175647
13	MP0008875_abnormal_xenobiotic_pharmacok	1.98198825
14	MP0006276_abnormal_autonomic_nervous	1.87886109
15	MP0001486_abnormal_startle_reflex	1.84965066
16	MP0003195_calcinosis	1.81069422
17	MP0008872_abnormal_physiological_respon	1.80255531
18	MP0002736_abnormal_nociception_after	1.79789576
19	MP0005645_abnormal_hypothalamus_physiol	1.78993028
20	MP0005253_abnormal_eye_physiology	1.76647609
21	MP0002876_abnormal_thyroid_physiology	1.74979084
22	MP0006072_abnormal_retinal_apoptosis	1.74660366
23	MP0004885_abnormal_endolymph	1.73468198
24	MP0003880_abnormal_central_pattern	1.67037684
25	MP0002653_abnormal_ependyma_morphology	1.65861609
26	MP0009745_abnormal_behavioral_response	1.61007893
27	MP0006292_abnormal_olfactory_placode	1.59998506
28	MP0003698_abnormal_male_reproductive	1.59962421
29	MP0002272_abnormal_nervous_system	1.59796497
30	MP0001529_abnormal_vocalization	1.59428325
31	MP0001501_abnormal_sleep_pattern	1.56060201
32	MP0005379_endocrine/exocrine_gland_phen	1.54223952
33	MP0001485_abnormal_pinna_reflex	1.54130750
34	MP0009046_muscle_twitch	1.53263854
35	MP0003011_delayed_dark_adaptation	1.53050658
36	MP0004133_heterotaxia	1.52706068
37	MP0002138_abnormal_hepatobiliary_system	1.52170626
38	MP0004142_abnormal_muscle_tone	1.51972484
39	MP0002638_abnormal_pupillary_reflex	1.51681342
40	MP0004742_abnormal_vestibular_system	1.50424004
41	MP0008995_early_reproductive_senescence	1.48409780
42	MP0002572_abnormal_emotion/affect_behav	1.44036307
43	MP0004147_increased_porphyrin_level	1.40411573
44	MP0001929_abnormal_gametogenesis	1.40161594
45	MP0002557_abnormal_social/conspecific_i	1.36735016
46	MP0000427_abnormal_hair_cycle	1.34986775
47	MP0008789_abnormal_olfactory_epithelium	1.33055883
48	MP0004145_abnormal_muscle_electrophysio	1.31526942
49	MP0005084_abnormal_gallbladder_morpholo	1.26464164
50	MP0003121_genomic_imprinting	1.25104678
51	MP0002735_abnormal_chemical_nociception	1.24227692
52	MP0001970_abnormal_pain_threshold	1.23052141
53	MP0005423_abnormal_somatic_nervous	1.22342629
54	MP0002733_abnormal_thermal_nociception	1.20507853
55	MP0003718_maternal_effect	1.19546490
56	MP0005646_abnormal_pituitary_gland	1.17423516
57	MP0003136_yellow_coat_color	1.16807229
58	MP0002928_abnormal_bile_duct	1.16039082
59	MP0000631_abnormal_neuroendocrine_gland	1.15359269
60	MP0003635_abnormal_synaptic_transmissio	1.07892977
61	MP0008775_abnormal_heart_ventricle	1.07773661
62	MP0002063_abnormal_learning/memory/cond	1.07201076
63	MP0002067_abnormal_sensory_capabilities	1.07020439
64	MP0002234_abnormal_pharynx_morphology	1.06585423
65	MP0005389_reproductive_system_phenotype	1.05222048
66	MP0001905_abnormal_dopamine_level	1.05013584
67	MP0003122_maternal_imprinting	1.04535144
68	MP0002229_neurodegeneration	1.04185196
69	MP0002254_reproductive_system_inflammat	1.03702239
70	MP0005499_abnormal_olfactory_system	1.01053266
71	MP0005394_taste/olfaction_phenotype	1.01053266
72	MP0002210_abnormal_sex_determination	1.00965291
73	MP0002184_abnormal_innervation	0.99072216
74	MP0002064_seizures	0.97974107
75	MP0002163_abnormal_gland_morphology	0.97943848
76	MP0005075_abnormal_melanosome_morpholog	0.94943753
77	MP0001963_abnormal_hearing_physiology	0.94909680
78	MP0005167_abnormal_blood-brain_barrier	0.94720839
79	MP0005386_behavior/neurological_phenoty	0.94608049
80	MP0004924_abnormal_behavior	0.94608049
81	MP0002160_abnormal_reproductive_system	0.91763889
82	MP0005195_abnormal_posterior_eye	0.91334903
83	MP0000026_abnormal_inner_ear	0.90964626
84	MP0001873_stomach_inflammation	0.90842573
85	MP0001764_abnormal_homeostasis	0.90555030
86	MP0002734_abnormal_mechanical_nocicepti	0.87897748
87	MP0004043_abnormal_pH_regulation	0.86336730
88	MP0000230_abnormal_systemic_arterial	0.85775768
89	MP0002752_abnormal_somatic_nervous	0.85446580
90	MP0000647_abnormal_sebaceous_gland	0.83381652
91	MP0000653_abnormal_sex_gland	0.83365059
92	MP0002909_abnormal_adrenal_gland	0.82600641
93	MP0001145_abnormal_male_reproductive	0.82535643
94	MP0002095_abnormal_skin_pigmentation	0.81597041
95	MP0005083_abnormal_biliary_tract	0.80139363
96	MP0000778_abnormal_nervous_system	0.79756650
97	MP0010329_abnormal_lipoprotein_level	0.77962255
98	MP0000383_abnormal_hair_follicle	0.77173735
99	MP0002693_abnormal_pancreas_physiology	0.76506489
100	MP0005332_abnormal_amino_acid	0.76318897

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.34605203
2	Pancreatic fibrosis (HP:0100732)	4.18349718
3	Nephronophthisis (HP:0000090)	4.12586517
4	Abnormal rod and cone electroretinograms (HP:0008323)	4.06285717
5	Attenuation of retinal blood vessels (HP:0007843)	3.88000926
6	Congenital stationary night blindness (HP:0007642)	3.81409979
7	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.78734885
8	True hermaphroditism (HP:0010459)	3.71393723
9	Abnormality of the renal cortex (HP:0011035)	3.59029340
10	Abnormality of the renal medulla (HP:0100957)	3.58405698
11	Molar tooth sign on MRI (HP:0002419)	3.58115800
12	Abnormality of midbrain morphology (HP:0002418)	3.58115800
13	Pendular nystagmus (HP:0012043)	3.57749737
14	Chronic hepatic failure (HP:0100626)	3.56338916
15	Type II lissencephaly (HP:0007260)	3.26993650
16	Medial flaring of the eyebrow (HP:0010747)	3.25311749
17	Abnormal drinking behavior (HP:0030082)	3.08330543
18	Polydipsia (HP:0001959)	3.08330543
19	Renal cortical cysts (HP:0000803)	2.92560259
20	Abolished electroretinogram (ERG) (HP:0000550)	2.86940000
21	Cystic liver disease (HP:0006706)	2.81984258
22	Keratoconus (HP:0000563)	2.80463027
23	Increased corneal curvature (HP:0100692)	2.80463027
24	Bony spicule pigmentary retinopathy (HP:0007737)	2.74790419
25	Tubulointerstitial nephritis (HP:0001970)	2.71190149
26	Tubular atrophy (HP:0000092)	2.63991503
27	Lissencephaly (HP:0001339)	2.62707524
28	Decreased central vision (HP:0007663)	2.62009325
29	Polyuria (HP:0000103)	2.53812030
30	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.51776893
31	Absent/shortened dynein arms (HP:0200106)	2.51776893
32	Severe visual impairment (HP:0001141)	2.51345579
33	Gait imbalance (HP:0002141)	2.50570245
34	Congenital primary aphakia (HP:0007707)	2.44316702
35	Bile duct proliferation (HP:0001408)	2.36766648
36	Abnormal biliary tract physiology (HP:0012439)	2.36766648
37	Sclerocornea (HP:0000647)	2.34795976
38	Nephrogenic diabetes insipidus (HP:0009806)	2.34642490
39	Abnormal respiratory motile cilium morphology (HP:0005938)	2.32935501
40	Abnormal respiratory epithelium morphology (HP:0012253)	2.32935501
41	Congenital hepatic fibrosis (HP:0002612)	2.31399785
42	Amelogenesis imperfecta (HP:0000705)	2.31093332
43	Anencephaly (HP:0002323)	2.27666647
44	Optic nerve hypoplasia (HP:0000609)	2.24133864
45	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.23942097
46	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.23054127
47	Abnormality of alanine metabolism (HP:0010916)	2.23054127
48	Hyperalaninemia (HP:0003348)	2.23054127
49	Abnormality of macular pigmentation (HP:0008002)	2.20367094
50	Abnormal urine output (HP:0012590)	2.19924756
51	Progressive cerebellar ataxia (HP:0002073)	2.18494974
52	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.17681925
53	Cerebellar dysplasia (HP:0007033)	2.14787975
54	Hyperglycinemia (HP:0002154)	2.14291159
55	Tubulointerstitial abnormality (HP:0001969)	2.13417766
56	Asplenia (HP:0001746)	2.12151471
57	Postaxial foot polydactyly (HP:0001830)	2.07948629
58	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.06791553
59	Hypomagnesemia (HP:0002917)	2.05904735
60	Pachygyria (HP:0001302)	2.03200562
61	Optic disc pallor (HP:0000543)	2.02027887
62	Genital tract atresia (HP:0001827)	2.01394499
63	Disproportionate short-trunk short stature (HP:0003521)	1.98282620
64	Inability to walk (HP:0002540)	1.94965062
65	Abnormality of dental color (HP:0011073)	1.94022337
66	Abnormality of renal excretion (HP:0011036)	1.93167697
67	Macular degeneration (HP:0000608)	1.92301718
68	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.92245831
69	Hyperventilation (HP:0002883)	1.90561250
70	Retinal dysplasia (HP:0007973)	1.90476337
71	Aplasia/hypoplasia of the uterus (HP:0008684)	1.90345642
72	Abnormal ciliary motility (HP:0012262)	1.89585133
73	Vaginal atresia (HP:0000148)	1.88970175
74	Agitation (HP:0000713)	1.87870077
75	Stomach cancer (HP:0012126)	1.87062126
76	Increased CSF lactate (HP:0002490)	1.86960699
77	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.86478616
78	Abnormality of the labia minora (HP:0012880)	1.85571823
79	Constricted visual fields (HP:0001133)	1.84412620
80	Male pseudohermaphroditism (HP:0000037)	1.83704039
81	Severe muscular hypotonia (HP:0006829)	1.83231451
82	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.82881946
83	Hyperglycinuria (HP:0003108)	1.81649099
84	Abnormal respiratory motile cilium physiology (HP:0012261)	1.80573971
85	Photophobia (HP:0000613)	1.78618134
86	Mitochondrial inheritance (HP:0001427)	1.76962625
87	Gaze-evoked nystagmus (HP:0000640)	1.76954713
88	Retinitis pigmentosa (HP:0000510)	1.76624920
89	Hypoalbuminemia (HP:0003073)	1.76557155
90	Abnormal albumin level (HP:0012116)	1.76557155
91	Glycosuria (HP:0003076)	1.76348500
92	Abnormality of urine glucose concentration (HP:0011016)	1.76348500
93	Occipital encephalocele (HP:0002085)	1.75293277
94	Acute necrotizing encephalopathy (HP:0006965)	1.75226910
95	Hypoproteinemia (HP:0003075)	1.74054376
96	Decreased circulating renin level (HP:0003351)	1.73756508
97	Intestinal atresia (HP:0011100)	1.72090375
98	Abnormality of glycine metabolism (HP:0010895)	1.71013650
99	Abnormality of serine family amino acid metabolism (HP:0010894)	1.71013650
100	Postaxial hand polydactyly (HP:0001162)	1.68343785

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.56949770
2	FRK	4.20586941
3	PLK4	3.05120933
4	WNK4	2.99745393
5	ADRBK2	2.93237305
6	INSRR	2.84536067
7	WNK3	2.52875388
8	PINK1	2.24672080
9	GRK1	2.13867438
10	ZAK	2.12470030
11	BMPR1B	2.08657804
12	STK39	2.07505306
13	MAP3K4	1.96863397
14	NUAK1	1.96860427
15	CASK	1.86851490
16	OXSR1	1.81540649
17	PLK2	1.79986595
18	MAPK13	1.69220694
19	TAOK3	1.67823572
20	TXK	1.54355768
21	STK38L	1.48739734
22	TIE1	1.47893989
23	MAP2K7	1.43986203
24	BCKDK	1.41905713
25	PNCK	1.41720245
26	TRIM28	1.37146562
27	MARK1	1.25690963
28	CSNK1G3	1.19334395
29	DYRK2	1.17727957
30	TLK1	1.17540436
31	CSNK1G1	1.13170859
32	CSNK1G2	1.08393228
33	PRKCG	1.07757640
34	BCR	1.01059117
35	MKNK2	0.97247509
36	PRKCE	0.95771080
37	IKBKB	0.94834214
38	CSNK1A1L	0.93898399
39	PHKG2	0.88297539
40	PHKG1	0.88297539
41	CAMK1G	0.86428598
42	DAPK2	0.84917012
43	CAMKK2	0.83704907
44	ADRBK1	0.81276281
45	PTK2B	0.81157542
46	PIK3CA	0.81114292
47	NTRK3	0.76600273
48	PAK3	0.75323467
49	ACVR1B	0.70421437
50	PIK3CG	0.66856278
51	MAPK15	0.66708482
52	MAPKAPK5	0.65672053
53	ERBB3	0.63355292
54	CAMK1	0.57438036
55	NTRK2	0.56000736
56	PRKCQ	0.55861326
57	PRKACA	0.55014362
58	VRK1	0.54833372
59	MAP2K6	0.54110832
60	CAMK2A	0.53641548
61	EPHA4	0.53447671
62	TEC	0.52572289
63	PKN1	0.51823227
64	BRD4	0.50926109
65	CSNK1D	0.50777060
66	CSNK1A1	0.50738557
67	ITK	0.50573037
68	MAP2K2	0.48974346
69	TYRO3	0.48737880
70	FGFR2	0.48667755
71	MUSK	0.48527498
72	EIF2AK3	0.48159717
73	CDK19	0.46265510
74	CHUK	0.46150517
75	BRSK2	0.44699490
76	TGFBR1	0.44209681
77	PRKCZ	0.42011865
78	MKNK1	0.41731593
79	MAP3K12	0.41486161
80	PRKG1	0.41428763
81	TNIK	0.40726063
82	PRKCI	0.39596839
83	PLK3	0.37882604
84	CDK8	0.37839941
85	PRKCA	0.37186147
86	CAMK1D	0.36284516
87	PRKAA2	0.35854625
88	PRKD3	0.34478340
89	GRK7	0.33928629
90	AKT3	0.33835508
91	BMPR2	0.33237303
92	DYRK1A	0.31962182
93	MAP2K4	0.31923227
94	RPS6KA5	0.31678528
95	MST4	0.31674422
96	CAMK2D	0.30960997
97	GRK6	0.29251577
98	DYRK1B	0.28692706
99	NEK6	0.28335902
100	CCNB1	0.28024508

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.09872978
2	Phototransduction_Homo sapiens_hsa04744	2.97891849
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.74871336
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.67943864
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.45830524
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.42353984
7	Butanoate metabolism_Homo sapiens_hsa00650	2.35734074
8	Nicotine addiction_Homo sapiens_hsa05033	2.30039385
9	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.17504215
10	Nitrogen metabolism_Homo sapiens_hsa00910	2.06530548
11	Oxidative phosphorylation_Homo sapiens_hsa00190	2.05088255
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.98744628
13	Olfactory transduction_Homo sapiens_hsa04740	1.96604132
14	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.88667640
15	Protein export_Homo sapiens_hsa03060	1.84852985
16	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.84021970
17	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.75342143
18	Taste transduction_Homo sapiens_hsa04742	1.70728785
19	Tryptophan metabolism_Homo sapiens_hsa00380	1.70317508
20	Propanoate metabolism_Homo sapiens_hsa00640	1.68982232
21	Selenocompound metabolism_Homo sapiens_hsa00450	1.66564719
22	Ether lipid metabolism_Homo sapiens_hsa00565	1.65146880
23	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.59527145
24	Caffeine metabolism_Homo sapiens_hsa00232	1.57473514
25	Parkinsons disease_Homo sapiens_hsa05012	1.42909069
26	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.38551749
27	Cardiac muscle contraction_Homo sapiens_hsa04260	1.38530078
28	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.37330659
29	Morphine addiction_Homo sapiens_hsa05032	1.36992166
30	Basal transcription factors_Homo sapiens_hsa03022	1.36444857
31	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.36100575
32	Homologous recombination_Homo sapiens_hsa03440	1.31408268
33	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.26295538
34	RNA polymerase_Homo sapiens_hsa03020	1.23552189
35	One carbon pool by folate_Homo sapiens_hsa00670	1.20559016
36	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.18392489
37	beta-Alanine metabolism_Homo sapiens_hsa00410	1.15435322
38	Peroxisome_Homo sapiens_hsa04146	1.12670886
39	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.11672537
40	RNA degradation_Homo sapiens_hsa03018	1.10296397
41	ABC transporters_Homo sapiens_hsa02010	1.07408460
42	Fanconi anemia pathway_Homo sapiens_hsa03460	1.03206994
43	Huntingtons disease_Homo sapiens_hsa05016	1.03171978
44	GABAergic synapse_Homo sapiens_hsa04727	1.00841377
45	Primary immunodeficiency_Homo sapiens_hsa05340	0.98901975
46	Chemical carcinogenesis_Homo sapiens_hsa05204	0.96550572
47	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.96330577
48	Insulin secretion_Homo sapiens_hsa04911	0.95966696
49	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.95712840
50	Serotonergic synapse_Homo sapiens_hsa04726	0.95688415
51	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.92222363
52	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.88714176
53	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.88429403
54	Glutamatergic synapse_Homo sapiens_hsa04724	0.87254829
55	Type I diabetes mellitus_Homo sapiens_hsa04940	0.85962075
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.85478409
57	Collecting duct acid secretion_Homo sapiens_hsa04966	0.84535793
58	Retinol metabolism_Homo sapiens_hsa00830	0.83253956
59	Alzheimers disease_Homo sapiens_hsa05010	0.81794195
60	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.81641138
61	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.81639486
62	Fatty acid metabolism_Homo sapiens_hsa01212	0.79733924
63	Fatty acid elongation_Homo sapiens_hsa00062	0.79321581
64	Circadian entrainment_Homo sapiens_hsa04713	0.78521707
65	Salivary secretion_Homo sapiens_hsa04970	0.76723805
66	Fatty acid degradation_Homo sapiens_hsa00071	0.74444029
67	Purine metabolism_Homo sapiens_hsa00230	0.73934593
68	Fat digestion and absorption_Homo sapiens_hsa04975	0.71085593
69	Metabolic pathways_Homo sapiens_hsa01100	0.69804879
70	Glycerolipid metabolism_Homo sapiens_hsa00561	0.66890183
71	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.65494054
72	Regulation of autophagy_Homo sapiens_hsa04140	0.64613974
73	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.63325131
74	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.62011129
75	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.61364944
76	Steroid biosynthesis_Homo sapiens_hsa00100	0.61105746
77	Asthma_Homo sapiens_hsa05310	0.59887898
78	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.58176470
79	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.57214022
80	RNA transport_Homo sapiens_hsa03013	0.51810165
81	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.50721779
82	Calcium signaling pathway_Homo sapiens_hsa04020	0.49559945
83	Histidine metabolism_Homo sapiens_hsa00340	0.48974084
84	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.48809260
85	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.47522176
86	Sulfur metabolism_Homo sapiens_hsa00920	0.46078453
87	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.45874445
88	Non-homologous end-joining_Homo sapiens_hsa03450	0.44841202
89	Dopaminergic synapse_Homo sapiens_hsa04728	0.43385251
90	Sulfur relay system_Homo sapiens_hsa04122	0.41847255
91	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.40856245
92	Pyrimidine metabolism_Homo sapiens_hsa00240	0.39632586
93	Graft-versus-host disease_Homo sapiens_hsa05332	0.39584079
94	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.38166499
95	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.37753591
96	Allograft rejection_Homo sapiens_hsa05330	0.36309397
97	Arginine and proline metabolism_Homo sapiens_hsa00330	0.35312399
98	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.34690238
99	cAMP signaling pathway_Homo sapiens_hsa04024	0.32622315
100	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.31457230

FGD5P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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