FGD6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1serotonin receptor signaling pathway (GO:0007210)8.00002215
2positive regulation of osteoblast proliferation (GO:0033690)7.78770837
3positive regulation of hair cycle (GO:0042635)7.49984129
4positive regulation of hair follicle development (GO:0051798)7.49984129
5negative regulation of interleukin-8 production (GO:0032717)6.77234946
6angiogenesis involved in wound healing (GO:0060055)6.47035175
7lymphangiogenesis (GO:0001946)6.36690186
8regulation of appetite (GO:0032098)6.27025391
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.26832498
10L-phenylalanine catabolic process (GO:0006559)6.26832498
11paraxial mesoderm development (GO:0048339)6.12955727
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.06620216
13protein K48-linked deubiquitination (GO:0071108)5.89859182
14negative regulation of circadian rhythm (GO:0042754)5.86193275
15L-phenylalanine metabolic process (GO:0006558)5.80434718
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.80434718
17glycoprotein catabolic process (GO:0006516)5.70027760
18regulation of hair follicle development (GO:0051797)5.68278405
19alpha-linolenic acid metabolic process (GO:0036109)5.64848179
20negative regulation of calcium ion transport into cytosol (GO:0010523)5.62656724
21aromatic amino acid family catabolic process (GO:0009074)5.62135944
22protein K63-linked deubiquitination (GO:0070536)5.52597651
23hematopoietic stem cell proliferation (GO:0071425)5.31278752
24urea metabolic process (GO:0019627)5.28325120
25urea cycle (GO:0000050)5.28325120
26kynurenine metabolic process (GO:0070189)5.16971027
27indolalkylamine catabolic process (GO:0046218)5.14930512
28tryptophan catabolic process (GO:0006569)5.14930512
29indole-containing compound catabolic process (GO:0042436)5.14930512
30interferon-gamma production (GO:0032609)5.13884673
31high-density lipoprotein particle remodeling (GO:0034375)5.07286255
32complement activation, alternative pathway (GO:0006957)4.96352208
33tryptophan metabolic process (GO:0006568)4.95763645
34peptidyl-glutamic acid carboxylation (GO:0017187)4.90454684
35protein carboxylation (GO:0018214)4.90454684
36regulation of protein activation cascade (GO:2000257)4.87985542
37bile acid biosynthetic process (GO:0006699)4.87610427
38reverse cholesterol transport (GO:0043691)4.83033681
39negative regulation of fibrinolysis (GO:0051918)4.79425125
40thyroid hormone metabolic process (GO:0042403)4.77516168
41nuclear pore organization (GO:0006999)4.76609999
42cysteine metabolic process (GO:0006534)4.74788397
43nitrogen cycle metabolic process (GO:0071941)4.74178792
44sulfur amino acid catabolic process (GO:0000098)4.64025496
45sulfation (GO:0051923)4.61022426
46regulation of complement activation (GO:0030449)4.58979009
47lipid translocation (GO:0034204)4.50131359
48phospholipid translocation (GO:0045332)4.50131359
49negative regulation of hormone biosynthetic process (GO:0032353)4.50009197
50phospholipid efflux (GO:0033700)4.49069314
51regulation of fibrinolysis (GO:0051917)4.48925227
52fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.48243564
53bile acid metabolic process (GO:0008206)4.42754759
54protein-lipid complex remodeling (GO:0034368)4.41802230
55macromolecular complex remodeling (GO:0034367)4.41802230
56plasma lipoprotein particle remodeling (GO:0034369)4.41802230
57glyoxylate metabolic process (GO:0046487)4.39481093
58regulation of triglyceride catabolic process (GO:0010896)4.38799496
59regulation of cholesterol esterification (GO:0010872)4.38301318
60carnitine transmembrane transport (GO:1902603)4.35316844
61negative regulation of cholesterol transport (GO:0032375)4.27134572
62negative regulation of sterol transport (GO:0032372)4.27134572
63homocysteine metabolic process (GO:0050667)4.24360794
64negative regulation of metanephros development (GO:0072217)4.23439937
65cholesterol efflux (GO:0033344)4.23312415
66plasma lipoprotein particle assembly (GO:0034377)4.23304344
67phospholipid homeostasis (GO:0055091)4.23156864
68plasma lipoprotein particle clearance (GO:0034381)4.22826991
69spindle assembly involved in mitosis (GO:0090307)4.22708365
70regulation of hair cycle (GO:0042634)4.21465032
71glycerophospholipid catabolic process (GO:0046475)4.15287357
72triglyceride homeostasis (GO:0070328)4.14962505
73acylglycerol homeostasis (GO:0055090)4.14962505
74bile acid and bile salt transport (GO:0015721)4.13754611
75serine family amino acid catabolic process (GO:0009071)4.13483992
76carnitine transport (GO:0015879)4.09487248
77amino-acid betaine transport (GO:0015838)4.09487248
78regulation of cholesterol homeostasis (GO:2000188)4.08226119
79DNA double-strand break processing (GO:0000729)4.07330343
80activated T cell proliferation (GO:0050798)4.05463871
81protein-lipid complex assembly (GO:0065005)4.01905408
82tyrosine metabolic process (GO:0006570)3.98328237
83negative regulation of hormone metabolic process (GO:0032351)3.97165586
84omega-hydroxylase P450 pathway (GO:0097267)3.91430559
85very-low-density lipoprotein particle assembly (GO:0034379)3.90283869
86aromatic amino acid family metabolic process (GO:0009072)3.90185347
87disruption of cells of other organism (GO:0044364)3.90167390
88killing of cells of other organism (GO:0031640)3.90167390
89lysine catabolic process (GO:0006554)3.85292788
90lysine metabolic process (GO:0006553)3.85292788
91amino-acid betaine metabolic process (GO:0006577)3.85253260
92regulation of sarcomere organization (GO:0060297)3.84050027
93granulocyte differentiation (GO:0030851)3.81405462
94regulation of bile acid biosynthetic process (GO:0070857)3.75391303
95mucosal immune response (GO:0002385)3.75336147
96positive regulation of epidermis development (GO:0045684)3.70519253
97cellular modified amino acid catabolic process (GO:0042219)3.68359723
98low-density lipoprotein particle remodeling (GO:0034374)3.68292500
99lipoprotein metabolic process (GO:0042157)3.68291145
100regulation of steroid hormone biosynthetic process (GO:0090030)3.67594298
101alpha-amino acid catabolic process (GO:1901606)3.66785084
102plasma lipoprotein particle organization (GO:0071827)3.66409850
103dicarboxylic acid biosynthetic process (GO:0043650)3.64971685
104cellular glucuronidation (GO:0052695)3.64931901
105glutamate metabolic process (GO:0006536)3.64796627
106heparan sulfate proteoglycan metabolic process (GO:0030201)3.64116712
107cholesterol homeostasis (GO:0042632)3.63973031
108regulation of osteoblast proliferation (GO:0033688)3.63275384
109positive regulation of lipid catabolic process (GO:0050996)3.62587995
110righting reflex (GO:0060013)3.61397874
111sterol homeostasis (GO:0055092)3.60674685
112indolalkylamine metabolic process (GO:0006586)3.58835464
113skin development (GO:0043588)3.57779517
114protein-lipid complex subunit organization (GO:0071825)3.57655274
115protein sumoylation (GO:0016925)3.57436290
116drug catabolic process (GO:0042737)3.56351919
117positive regulation of lipoprotein lipase activity (GO:0051006)3.53895149
118positive regulation of triglyceride lipase activity (GO:0061365)3.53895149
119fibrinolysis (GO:0042730)3.51868983
120ethanol oxidation (GO:0006069)3.49628966
121complement activation, classical pathway (GO:0006958)3.49366120
122negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.49088013
123intestinal cholesterol absorption (GO:0030299)3.47513671
124positive regulation of fatty acid beta-oxidation (GO:0032000)3.46013992
125complement activation (GO:0006956)3.45838259
126endothelial cell proliferation (GO:0001935)3.42008261
127coenzyme catabolic process (GO:0009109)3.41756254
128rRNA catabolic process (GO:0016075)3.38596911
129imidazole-containing compound metabolic process (GO:0052803)3.36991303
130organ or tissue specific immune response (GO:0002251)3.36953116
131cellular biogenic amine catabolic process (GO:0042402)3.36541724
132amine catabolic process (GO:0009310)3.36541724
133regulation of hippo signaling (GO:0035330)3.36045103
134cellular ketone body metabolic process (GO:0046950)3.35332399
135cellular amino acid catabolic process (GO:0009063)3.35275368
136organic cation transport (GO:0015695)3.34873126
137protein activation cascade (GO:0072376)3.33984273
138quaternary ammonium group transport (GO:0015697)3.32329377
139benzene-containing compound metabolic process (GO:0042537)3.30934965
140establishment of protein localization to Golgi (GO:0072600)3.30919238
141arginine metabolic process (GO:0006525)3.30071500
142microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.27260208
143positive regulation of triglyceride metabolic process (GO:0090208)3.26561297
144carnitine metabolic process (GO:0009437)3.26097771
145myoblast migration (GO:0051451)3.25818450
146flavonoid metabolic process (GO:0009812)3.23835098
147regulation of membrane lipid distribution (GO:0097035)3.23394008
148negative regulation of protein activation cascade (GO:2000258)3.22439093
149negative regulation of lipase activity (GO:0060192)3.22347543
150linoleic acid metabolic process (GO:0043651)3.18518709
151bundle of His cell to Purkinje myocyte communication (GO:0086069)3.17264203
152androgen biosynthetic process (GO:0006702)3.17211231
153cholesterol transport (GO:0030301)3.16444486
154sterol transport (GO:0015918)3.16444486
155regulation of cholesterol biosynthetic process (GO:0045540)3.15856545
156glycine metabolic process (GO:0006544)3.14354537
157regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.14226311
158maturation of 5.8S rRNA (GO:0000460)3.14109899
159sex differentiation (GO:0007548)3.12546539
160reflex (GO:0060004)3.11064793
161uronic acid metabolic process (GO:0006063)3.10265294
162glucuronate metabolic process (GO:0019585)3.10265294
163lipid homeostasis (GO:0055088)3.08639986
164serine family amino acid metabolic process (GO:0009069)3.08594153
165negative regulation of keratinocyte proliferation (GO:0010839)3.08334005
166purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.07075588
1673-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.07075588
168acute-phase response (GO:0006953)3.05928247
169synapsis (GO:0007129)3.04492861
170regulation of gene silencing by miRNA (GO:0060964)3.03353900
171regulation of gene silencing by RNA (GO:0060966)3.03353900
172regulation of posttranscriptional gene silencing (GO:0060147)3.03353900
173positive regulation of vasculogenesis (GO:2001214)3.00468563
174regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.00210912
175defense response to fungus (GO:0050832)2.97578819
176negative regulation by host of viral transcription (GO:0043922)2.95489902
177startle response (GO:0001964)2.92271912
178positive regulation of cAMP-mediated signaling (GO:0043950)2.91593823
179meiotic cell cycle (GO:0051321)2.91229031
180replication fork processing (GO:0031297)2.90832847
181regulation of establishment of cell polarity (GO:2000114)2.90436005
182regulation of glucocorticoid metabolic process (GO:0031943)2.87583712
183protein-cofactor linkage (GO:0018065)2.87298184
184regulation of mesenchymal cell apoptotic process (GO:2001053)2.86655996
185thyroid hormone generation (GO:0006590)2.84771235
186detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.84344522
187protein K6-linked ubiquitination (GO:0085020)2.76415051
188regulation of stem cell maintenance (GO:2000036)2.73718774
189sex determination (GO:0007530)2.73555897
190peptidyl-threonine dephosphorylation (GO:0035970)2.73329321
191positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.73323972
192negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.70333030
193biotin metabolic process (GO:0006768)2.69899166
194protein K11-linked deubiquitination (GO:0035871)13.8197234

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.00867556
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.69572586
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.80580275
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.63144876
5GBX2_23144817_ChIP-Seq_PC3_Human5.43139128
6EGR1_23403033_ChIP-Seq_LIVER_Mouse5.30464471
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.18298432
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.61994855
9SMAD_19615063_ChIP-ChIP_OVARY_Human3.26191715
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.16657204
11TAF15_26573619_Chip-Seq_HEK293_Human3.12893709
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.07434804
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.68484137
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.59188580
15IKZF1_21737484_ChIP-ChIP_HCT116_Human2.53789751
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.31837544
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.26997788
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.18109838
19FOXA2_19822575_ChIP-Seq_HepG2_Human2.10933264
20SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.05339358
21RBPJ_22232070_ChIP-Seq_NCS_Mouse2.03997102
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.02901614
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96425435
24SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.92832480
25P300_19829295_ChIP-Seq_ESCs_Human1.91491632
26AR_21572438_ChIP-Seq_LNCaP_Human1.87803318
27FUS_26573619_Chip-Seq_HEK293_Human1.85138230
28* SMAD4_21799915_ChIP-Seq_A2780_Human1.82595382
29* AR_25329375_ChIP-Seq_VCAP_Human1.82507564
30TP53_18474530_ChIP-ChIP_U2OS_Human1.80229235
31SMAD3_21741376_ChIP-Seq_EPCs_Human1.76764495
32STAT3_23295773_ChIP-Seq_U87_Human1.76721880
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.76112762
34CLOCK_20551151_ChIP-Seq_293T_Human1.74545109
35* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.73036870
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.71632662
37IGF1R_20145208_ChIP-Seq_DFB_Human1.70097518
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69594062
39TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.65538673
40ZNF274_21170338_ChIP-Seq_K562_Hela1.63740070
41ER_23166858_ChIP-Seq_MCF-7_Human1.63328986
42TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.61519506
43SMAD4_21741376_ChIP-Seq_EPCs_Human1.60323402
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59415524
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57306976
46SMAD3_21741376_ChIP-Seq_HESCs_Human1.55309069
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54314000
48LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51648396
49TCF4_23295773_ChIP-Seq_U87_Human1.51434847
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51386427
51SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.49431235
52* FOXO3_23340844_ChIP-Seq_DLD1_Human1.48441021
53* EWS_26573619_Chip-Seq_HEK293_Human1.47851810
54* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.47439484
55HNF4A_19822575_ChIP-Seq_HepG2_Human1.46830178
56TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45772529
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45338679
58CBP_20019798_ChIP-Seq_JUKART_Human1.45338679
59NR3C1_21868756_ChIP-Seq_MCF10A_Human1.45275103
60BRD4_25478319_ChIP-Seq_HGPS_Human1.45126677
61MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44663002
62IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.41486957
63ESR2_21235772_ChIP-Seq_MCF-7_Human1.40326466
64VDR_22108803_ChIP-Seq_LS180_Human1.39030251
65SALL4_18804426_ChIP-ChIP_XEN_Mouse1.35375769
66STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.34718912
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34310430
68TCF4_22108803_ChIP-Seq_LS180_Human1.31756675
69BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.29873233
70HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.29153318
71RUNX2_22187159_ChIP-Seq_PCA_Human1.29117771
72* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.27834437
73FOXA1_21572438_ChIP-Seq_LNCaP_Human1.27285238
74* EZH2_27294783_Chip-Seq_NPCs_Mouse1.26712727
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25841448
76PPAR_26484153_Chip-Seq_NCI-H1993_Human1.23044586
77GATA4_25053715_ChIP-Seq_YYC3_Human1.21891274
78GATA1_22025678_ChIP-Seq_K562_Human1.21594677
79TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21327003
80SALL1_21062744_ChIP-ChIP_HESCs_Human1.20440715
81ESR1_21235772_ChIP-Seq_MCF-7_Human1.19509911
82* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18842537
83CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.16945541
84KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15345907
85* FLI1_21867929_ChIP-Seq_TH2_Mouse1.15174403
86* CRX_20693478_ChIP-Seq_RETINA_Mouse1.13503682
87IRF8_22096565_ChIP-ChIP_GC-B_Human1.13294432
88TBL1_22424771_ChIP-Seq_293T_Human1.12813219
89P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12491593
90ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09703084
91JUN_21703547_ChIP-Seq_K562_Human1.09520024
92NANOG_18555785_Chip-Seq_ESCs_Mouse1.09166372
93WT1_19549856_ChIP-ChIP_CCG9911_Human1.08978989
94AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.08585080
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08503159
96KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08496089
97BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08455873
98DROSHA_22980978_ChIP-Seq_HELA_Human1.08090568
99* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.07686739
100E2F7_22180533_ChIP-Seq_HELA_Human1.06545476
101RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.06005296
102ARNT_22903824_ChIP-Seq_MCF-7_Human1.05730313
103* SMAD4_21741376_ChIP-Seq_HESCs_Human1.05009899
104GATA6_25053715_ChIP-Seq_YYC3_Human1.04102809
105NFE2_27457419_Chip-Seq_LIVER_Mouse1.03506439
106TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03137794
107NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02133796
108AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01942423
109CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.01681428
110TP53_22573176_ChIP-Seq_HFKS_Human1.01611168
111STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00451119
112AR_19668381_ChIP-Seq_PC3_Human0.98257975
113PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.97801794
114SMAD3_21741376_ChIP-Seq_ESCs_Human0.97039170
115* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96219859
116PHF8_20622853_ChIP-Seq_HELA_Human0.96208141
117CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95968138
118SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95584238
119GATA1_26923725_Chip-Seq_HPCs_Mouse0.95496518
120TCF4_18268006_ChIP-ChIP_LS174T_Human0.95252748
121CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95171536
122CDX2_22108803_ChIP-Seq_LS180_Human0.94061168
123* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93838232
124FOXA1_25552417_ChIP-Seq_VCAP_Human0.93602076
125CMYC_18555785_Chip-Seq_ESCs_Mouse0.93262171
126* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.93042495
127FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.91771332
128GATA2_21666600_ChIP-Seq_HMVEC_Human0.90697304
129THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.90391627
130IRF8_27001747_Chip-Seq_BMDM_Mouse0.89503608
131FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.88602430
132KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.88116162
133ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87900296
134FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87313516
135BCAT_22108803_ChIP-Seq_LS180_Human0.86525598
136ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85490403
137HTT_18923047_ChIP-ChIP_STHdh_Human0.85282601
138NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.83778971
139NRF2_20460467_ChIP-Seq_MEFs_Mouse0.83778971
140TP63_23658742_ChIP-Seq_EP156T_Human0.81503224
141* ESR1_20079471_ChIP-ChIP_T-47D_Human0.80658534
142FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80284672
143* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.79784281
144* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.79004878
145TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.75307182
146CJUN_26792858_Chip-Seq_BT549_Human0.72583072
147KAP1_22055183_ChIP-Seq_ESCs_Mouse0.71773712
148PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.71309972
149RXRA_24833708_ChIP-Seq_LIVER_Mouse0.70974640
150RARG_19884340_ChIP-ChIP_MEFs_Mouse0.70740233
151VDR_24787735_ChIP-Seq_THP-1_Human0.70552786
152KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.70204983
153TBX20_22080862_ChIP-Seq_HEART_Mouse0.69831393
154TBX20_22328084_ChIP-Seq_HEART_Mouse0.69831393
155TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.69390295
156* GATA2_19941826_ChIP-Seq_K562_Human0.68871703
157CDX2_20551321_ChIP-Seq_CACO-2_Human0.67672453
158SOX2_20726797_ChIP-Seq_SW620_Human0.67110230
159GATA1_19941826_ChIP-Seq_K562_Human0.67050744
160CDX2_19796622_ChIP-Seq_MESCs_Mouse0.66946255
161ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.66622443
162AUTS2_25519132_ChIP-Seq_293T-REX_Human0.65503316
163TP53_16413492_ChIP-PET_HCT116_Human0.64924622
164* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.63876924
165BRD4_27068464_Chip-Seq_AML-cells_Mouse0.63495279
166AR_21909140_ChIP-Seq_LNCAP_Human0.63012900
167GATA3_24758297_ChIP-Seq_MCF-7_Human0.62386311
168ESR1_15608294_ChIP-ChIP_MCF-7_Human0.61656288
169SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.61378603
170RXR_22108803_ChIP-Seq_LS180_Human0.61208908
171PIAS1_25552417_ChIP-Seq_VCAP_Human0.61065317
172SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.60019828
173CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.59717240
174AHR_22903824_ChIP-Seq_MCF-7_Human0.58375888
175TP63_17297297_ChIP-ChIP_HaCaT_Human0.58209257
176RUNX1_27514584_Chip-Seq_MCF-7_Human0.57448998
177PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.56431735
178IRF8_21731497_ChIP-ChIP_J774_Mouse0.55777831
179* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.55470358

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.47031460
2MP0005360_urolithiasis6.55014734
3MP0005365_abnormal_bile_salt5.53971626
4MP0005085_abnormal_gallbladder_physiolo5.50798027
5MP0008875_abnormal_xenobiotic_pharmacok4.34143959
6MP0003252_abnormal_bile_duct3.84152864
7MP0009840_abnormal_foam_cell3.54952272
8MP0005310_abnormal_salivary_gland3.42933068
9MP0010329_abnormal_lipoprotein_level3.38392055
10MP0001984_abnormal_olfaction3.11209564
11MP0003806_abnormal_nucleotide_metabolis3.06113184
12MP0005083_abnormal_biliary_tract2.92719715
13MP0000383_abnormal_hair_follicle2.68954356
14MP0001879_abnormal_lymphatic_vessel2.66943980
15MP0001666_abnormal_nutrient_absorption2.54381143
16MP0003941_abnormal_skin_development2.41599611
17MP0003705_abnormal_hypodermis_morpholog2.15495172
18MP0000609_abnormal_liver_physiology2.13955568
19MP0004043_abnormal_pH_regulation2.12839427
20MP0005332_abnormal_amino_acid2.06392201
21MP0003191_abnormal_cellular_cholesterol2.00605084
22MP0003868_abnormal_feces_composition1.99572621
23MP0003195_calcinosis1.96623438
24MP0002118_abnormal_lipid_homeostasis1.92827870
25MP0003315_abnormal_perineum_morphology1.87191854
26MP0002138_abnormal_hepatobiliary_system1.82076735
27MP0004019_abnormal_vitamin_homeostasis1.73451303
28MP0002254_reproductive_system_inflammat1.72846488
29MP0001919_abnormal_reproductive_system1.71478093
30MP0002234_abnormal_pharynx_morphology1.67177699
31MP0005451_abnormal_body_composition1.64967575
32MP0000762_abnormal_tongue_morphology1.63517472
33MP0000613_abnormal_salivary_gland1.61582744
34MP0010368_abnormal_lymphatic_system1.56413367
35MP0004272_abnormal_basement_membrane1.50441703
36MP0001348_abnormal_lacrimal_gland1.45423941
37MP0005319_abnormal_enzyme/_coenzyme1.44790054
38MP0006054_spinal_hemorrhage1.44369549
39MP0003937_abnormal_limbs/digits/tail_de1.42757405
40MP0002006_tumorigenesis1.41713001
41MP0003300_gastrointestinal_ulcer1.41670643
42MP0005389_reproductive_system_phenotype1.37700184
43MP0004264_abnormal_extraembryonic_tissu1.36659932
44MP0005084_abnormal_gallbladder_morpholo1.35166555
45MP0001299_abnormal_eye_distance/1.31721148
46MP0003656_abnormal_erythrocyte_physiolo1.26880904
47MP0003936_abnormal_reproductive_system1.24709900
48MP0010234_abnormal_vibrissa_follicle1.22451145
49MP0009697_abnormal_copulation1.20789775
50MP0005551_abnormal_eye_electrophysiolog1.19916272
51MP0005647_abnormal_sex_gland1.19669791
52MP0008057_abnormal_DNA_replication1.16808340
53MP0000604_amyloidosis1.16558577
54MP0000598_abnormal_liver_morphology1.14132520
55MP0001873_stomach_inflammation1.12766929
56MP0010352_gastrointestinal_tract_polyps1.11624757
57MP0004957_abnormal_blastocyst_morpholog1.11616404
58MP0005408_hypopigmentation1.08336678
59MP0009643_abnormal_urine_homeostasis1.07028945
60MP0005377_hearing/vestibular/ear_phenot1.03404351
61MP0003878_abnormal_ear_physiology1.03404351
62MP0005584_abnormal_enzyme/coenzyme_acti1.02673895
63MP0009764_decreased_sensitivity_to1.01767190
64MP0010094_abnormal_chromosome_stability1.01197077
65MP0002127_abnormal_cardiovascular_syste1.00172689
66MP0003119_abnormal_digestive_system0.98789134
67MP0000230_abnormal_systemic_arterial0.98746459
68MP0003011_delayed_dark_adaptation0.97660763
69MP0002970_abnormal_white_adipose0.96623904
70MP0000537_abnormal_urethra_morphology0.96325254
71MP0001346_abnormal_lacrimal_gland0.96303248
72MP0000569_abnormal_digit_pigmentation0.95682784
73MP0006276_abnormal_autonomic_nervous0.95465172
74MP0009763_increased_sensitivity_to0.94212633
75MP0000432_abnormal_head_morphology0.92862433
76MP0005248_abnormal_Harderian_gland0.92308987
77MP0003718_maternal_effect0.91919087
78MP0010030_abnormal_orbit_morphology0.91496481
79MP0000566_synostosis0.90294311
80MP0000579_abnormal_nail_morphology0.90148844
81MP0005058_abnormal_lysosome_morphology0.89326882
82MP0005670_abnormal_white_adipose0.89184321
83MP0003690_abnormal_glial_cell0.88819846
84MP0003984_embryonic_growth_retardation0.88533419
85MP0003935_abnormal_craniofacial_develop0.88316872
86MP0005395_other_phenotype0.87287906
87MP0002098_abnormal_vibrissa_morphology0.86672884
88MP0002088_abnormal_embryonic_growth/wei0.86101042
89MP0003453_abnormal_keratinocyte_physiol0.86040462
90MP0002084_abnormal_developmental_patter0.85739520
91MP0002971_abnormal_brown_adipose0.85106196
92MP0005220_abnormal_exocrine_pancreas0.83388787
93MP0005257_abnormal_intraocular_pressure0.81642010
94MP0004215_abnormal_myocardial_fiber0.81343937
95MP0003186_abnormal_redox_activity0.81259382
96MP0005380_embryogenesis_phenotype0.80713119
97MP0001672_abnormal_embryogenesis/_devel0.80713119
98MP0001764_abnormal_homeostasis0.80269871
99MP0002697_abnormal_eye_size0.79948580
100MP0002876_abnormal_thyroid_physiology0.79860430
101MP0004085_abnormal_heartbeat0.79315853
102MP0004084_abnormal_cardiac_muscle0.78454345
103MP0000627_abnormal_mammary_gland0.76149078
104MP0005187_abnormal_penis_morphology0.75460663
105MP0009046_muscle_twitch0.74815243
106MP0005275_abnormal_skin_tensile0.73823959
107MP0004185_abnormal_adipocyte_glucose0.73411448
108MP0002233_abnormal_nose_morphology0.73254051
109MP0003183_abnormal_peptide_metabolism0.72714363
110MP0002078_abnormal_glucose_homeostasis0.72410457
111MP0001286_abnormal_eye_development0.72391626
112MP0008469_abnormal_protein_level0.72310354
113MP0003436_decreased_susceptibility_to0.71817492
114MP0004130_abnormal_muscle_cell0.71552431
115MP0009053_abnormal_anal_canal0.70575096
116MP0009642_abnormal_blood_homeostasis0.69814636
117MP0004782_abnormal_surfactant_physiolog0.69311191
118MP0004947_skin_inflammation0.69185938
119MP0002925_abnormal_cardiovascular_devel0.68950639
120MP0005076_abnormal_cell_differentiation0.68146910
121MP0000639_abnormal_adrenal_gland0.67977344
122MP0002168_other_aberrant_phenotype0.67241301
123MP0010386_abnormal_urinary_bladder0.66991529
124MP0005167_abnormal_blood-brain_barrier0.66414382
125MP0001915_intracranial_hemorrhage0.66362872
126MP0004858_abnormal_nervous_system0.65585052
127MP0003638_abnormal_response/metabolism_0.65188164
128MP0000428_abnormal_craniofacial_morphol0.65127443
129MP0003303_peritoneal_inflammation0.64777114
130MP0002085_abnormal_embryonic_tissue0.64509310
131MP0009384_cardiac_valve_regurgitation0.63818654
132MP0005666_abnormal_adipose_tissue0.63686853
133MP0008961_abnormal_basal_metabolism0.63298548
134MP0000427_abnormal_hair_cycle0.63218656
135MP0000631_abnormal_neuroendocrine_gland0.63193298
136MP0002269_muscular_atrophy0.62980256
137MP0002796_impaired_skin_barrier0.62467546
138MP0010678_abnormal_skin_adnexa0.62196075
139MP0000467_abnormal_esophagus_morphology0.61681827
140MP0005197_abnormal_uvea_morphology0.61083072
141MP0005334_abnormal_fat_pad0.60660704
142MP0003646_muscle_fatigue0.59959467
143MP0003755_abnormal_palate_morphology0.59164833
144MP0003699_abnormal_female_reproductive0.58736509
145MP0002210_abnormal_sex_determination0.58679226
146MP0003693_abnormal_embryo_hatching0.58325465
147MP0002928_abnormal_bile_duct0.58323016
148MP0000647_abnormal_sebaceous_gland0.58024341
149MP0005636_abnormal_mineral_homeostasis0.57714541
150MP0003943_abnormal_hepatobiliary_system0.57583226
151MP0005023_abnormal_wound_healing0.57227002
152MP0009250_abnormal_appendicular_skeleto0.56004817
153MP0009115_abnormal_fat_cell0.55977900
154MP0005464_abnormal_platelet_physiology0.55548140
155MP0001849_ear_inflammation0.54341727
156MP0001661_extended_life_span0.53630960
157MP0008877_abnormal_DNA_methylation0.53502147
158MP0009672_abnormal_birth_weight0.53138588
159MP0001614_abnormal_blood_vessel0.53059217
160MP0002136_abnormal_kidney_physiology0.53048630
161MP0001784_abnormal_fluid_regulation0.52925105
162MP0001881_abnormal_mammary_gland0.52293447
163MP0001756_abnormal_urination0.52175784
164MP0003566_abnormal_cell_adhesion0.52093593
165MP0003724_increased_susceptibility_to0.51421845
166MP0003890_abnormal_embryonic-extraembry0.50235174
167MP0009765_abnormal_xenobiotic_induced0.47172220
168MP0005376_homeostasis/metabolism_phenot0.47015304
169MP0005166_decreased_susceptibility_to0.46490392
170MP0003329_amyloid_beta_deposits0.45301026
171MP0000767_abnormal_smooth_muscle0.44893508
172MP0001944_abnormal_pancreas_morphology0.44856502
173MP0003091_abnormal_cell_migration0.43974298
174MP0000249_abnormal_blood_vessel0.43816445

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.02983804
2Intrahepatic cholestasis (HP:0001406)6.64362481
3Abnormal pancreas size (HP:0012094)5.91681979
4Xanthomatosis (HP:0000991)5.88722749
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.88346711
6Abnormality of aromatic amino acid family metabolism (HP:0004338)5.71396669
7Prolonged partial thromboplastin time (HP:0003645)5.40186152
8Hypobetalipoproteinemia (HP:0003563)5.33534438
9Hyperlipoproteinemia (HP:0010980)5.08976132
10Bilateral sensorineural hearing impairment (HP:0008619)5.00668041
11Complement deficiency (HP:0004431)4.99948547
12Congenital sensorineural hearing impairment (HP:0008527)4.93322474
13Poikiloderma (HP:0001029)4.81097326
14Lower limb hyperreflexia (HP:0002395)4.71429040
15Hypolipoproteinemia (HP:0010981)4.61178103
16Hypoalphalipoproteinemia (HP:0003233)4.58712029
17Epidermoid cyst (HP:0200040)4.36989643
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.23047340
19Abnormality of the common coagulation pathway (HP:0010990)4.19669026
20Joint hemorrhage (HP:0005261)4.18617675
21Abnormality of sulfur amino acid metabolism (HP:0004339)3.90069417
22Hypoplasia of the uterus (HP:0000013)3.80600066
23Decreased circulating renin level (HP:0003351)3.77179714
24Hypercholesterolemia (HP:0003124)3.72674353
25Fat malabsorption (HP:0002630)3.70334294
26Myocardial infarction (HP:0001658)3.67560921
27Hypoglycemic coma (HP:0001325)3.66659615
28Abnormality of complement system (HP:0005339)3.65881734
29Conjugated hyperbilirubinemia (HP:0002908)3.60009592
30Abnormality of glutamine family amino acid metabolism (HP:0010902)3.58124698
31Hyperammonemia (HP:0001987)3.56432774
32Ketosis (HP:0001946)3.46072068
33Abnormality of methionine metabolism (HP:0010901)3.41313151
34Abnormality of the intrinsic pathway (HP:0010989)3.39352763
35Preaxial foot polydactyly (HP:0001841)3.38922171
36Abnormality of aspartate family amino acid metabolism (HP:0010899)3.34157038
37Keratoconjunctivitis (HP:0001096)3.29214933
38Esophageal varix (HP:0002040)3.23495904
39Optic neuritis (HP:0100653)3.18300939
40Retrobulbar optic neuritis (HP:0100654)3.18300939
41Gonadotropin excess (HP:0000837)3.14360941
42Hyperglycinemia (HP:0002154)3.14219061
43Enlarged penis (HP:0000040)3.03496477
44Bicornuate uterus (HP:0000813)2.96241188
45Attenuation of retinal blood vessels (HP:0007843)2.94986677
46Systemic lupus erythematosus (HP:0002725)2.91797007
47Abnormality of pyrimidine metabolism (HP:0004353)2.90264793
48Hepatocellular carcinoma (HP:0001402)2.89932119
49True hermaphroditism (HP:0010459)2.86465745
50Aplasia/Hypoplasia of the tibia (HP:0005772)2.83647178
51Recurrent gram-negative bacterial infections (HP:0005420)2.83483678
52Abnormality of nucleobase metabolism (HP:0010932)2.82483377
53Abolished electroretinogram (ERG) (HP:0000550)2.80335880
54Abnormality of purine metabolism (HP:0004352)2.78592668
55Hyperglycinuria (HP:0003108)2.77952421
56Hyperglycemia (HP:0003074)2.76697120
57Abnormality of serine family amino acid metabolism (HP:0010894)2.76091425
58Abnormality of glycine metabolism (HP:0010895)2.76091425
59Hypoglycemic seizures (HP:0002173)2.74784806
60Hyperventilation (HP:0002883)2.74580141
61Hypoplastic labia majora (HP:0000059)2.74502256
62Malnutrition (HP:0004395)2.71578579
63Hemorrhage of the eye (HP:0011885)2.70480684
64Breast carcinoma (HP:0003002)2.70444708
65Unilateral renal agenesis (HP:0000122)2.69537870
66Acanthocytosis (HP:0001927)2.68870947
67Hypochromic microcytic anemia (HP:0004840)2.67701358
68Aplasia/hypoplasia of the uterus (HP:0008684)2.67304702
69Skin nodule (HP:0200036)2.64698195
70Amelogenesis imperfecta (HP:0000705)2.61962836
71Abnormality of the dental pulp (HP:0006479)2.59651779
72Pancreatic cysts (HP:0001737)2.58571346
73Hyperbilirubinemia (HP:0002904)2.57866231
74Ketoacidosis (HP:0001993)2.55552756
75Orchitis (HP:0100796)2.54983244
76Spontaneous abortion (HP:0005268)2.54527557
77Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.54438740
78Glomerulonephritis (HP:0000099)2.53312045
79Vascular calcification (HP:0004934)2.51645630
80Steatorrhea (HP:0002570)2.51549773
81Bicuspid aortic valve (HP:0001647)2.50275653
82Abnormality of the pericardium (HP:0001697)2.49438948
83Absent radius (HP:0003974)2.44247303
84Abnormality of the labia majora (HP:0012881)2.42851129
85Chronic hepatic failure (HP:0100626)2.40001446
86Mitral stenosis (HP:0001718)2.38753016
87Bony spicule pigmentary retinopathy (HP:0007737)2.38367364
88Tubular atrophy (HP:0000092)2.34478373
89Aplasia/Hypoplasia of the uvula (HP:0010293)2.32354008
90Aplasia involving forearm bones (HP:0009822)2.28562148
91Absent forearm bone (HP:0003953)2.28562148
92Cortical dysplasia (HP:0002539)2.27735938
93Sensorimotor neuropathy (HP:0007141)2.25885726
94Hyperinsulinemic hypoglycemia (HP:0000825)2.24703227
95Abnormal gallbladder morphology (HP:0012437)2.24277482
96Male pseudohermaphroditism (HP:0000037)2.24099498
97Keratoconjunctivitis sicca (HP:0001097)2.24084512
98Late onset (HP:0003584)2.22762522
99Bilateral microphthalmos (HP:0007633)2.22206158
100Spastic diplegia (HP:0001264)2.21766950
101Cardiovascular calcification (HP:0011915)2.21562367
102Abnormality of fatty-acid metabolism (HP:0004359)2.21242520
103Cholecystitis (HP:0001082)2.19689344
104Abnormal gallbladder physiology (HP:0012438)2.19689344
105Cholelithiasis (HP:0001081)2.18198106
106Abnormal lung lobation (HP:0002101)2.13411154
107Gingival bleeding (HP:0000225)2.13328447
108Neoplasm of the adrenal cortex (HP:0100641)2.12762255
109Pancreatic fibrosis (HP:0100732)2.12673338
110Delayed puberty (HP:0000823)2.11326191
111Nephritis (HP:0000123)2.09979843
112Polycythemia (HP:0001901)2.09617939
113Hyperaldosteronism (HP:0000859)2.09379878
114Gout (HP:0001997)2.09151834
115Congenital stationary night blindness (HP:0007642)2.07665483
116Spastic paraplegia (HP:0001258)2.06038993
117Delayed CNS myelination (HP:0002188)2.05558761
118Amyloidosis (HP:0011034)2.05319045
119Abnormality of dentin (HP:0010299)2.05099976
120Shawl scrotum (HP:0000049)2.00737922
121Poikilocytosis (HP:0004447)2.00342757
122Absent speech (HP:0001344)1.99771270
123Upper motor neuron abnormality (HP:0002127)1.99568042
124Small intestinal stenosis (HP:0012848)1.97082071
125Duodenal stenosis (HP:0100867)1.97082071
126Focal segmental glomerulosclerosis (HP:0000097)1.96253818
127Turricephaly (HP:0000262)1.94759950
128Abnormality of chromosome stability (HP:0003220)1.94722900
129Biliary tract neoplasm (HP:0100574)1.94273991
130Abnormality of proline metabolism (HP:0010907)1.93460667
131Hydroxyprolinuria (HP:0003080)1.93460667
132Back pain (HP:0003418)1.93142180
133Stage 5 chronic kidney disease (HP:0003774)1.92996069
134Hyperactive renin-angiotensin system (HP:0000841)1.92655232
135Menorrhagia (HP:0000132)1.91966028
136Fair hair (HP:0002286)1.90646424
137Tinnitus (HP:0000360)1.90379481
138Chromosomal breakage induced by crosslinking agents (HP:0003221)1.90198649
139Abnormality of serum amino acid levels (HP:0003112)1.88603423
140Meckel diverticulum (HP:0002245)1.87161515
141Abnormality of the gallbladder (HP:0005264)1.86962142
142Subaortic stenosis (HP:0001682)1.84022863
143Abnormality of the left ventricular outflow tract (HP:0011103)1.84022863
144Hyperkalemia (HP:0002153)1.83707266
145Abnormality of the ileum (HP:0001549)1.83405868
146Protuberant abdomen (HP:0001538)1.83301855
147Nephroblastoma (Wilms tumor) (HP:0002667)1.82859688
148Embryonal renal neoplasm (HP:0011794)1.82747581
149Abnormality of the ischium (HP:0003174)1.82272999
150Metabolic acidosis (HP:0001942)1.82258562
151Esophageal atresia (HP:0002032)1.81891226
152Choanal atresia (HP:0000453)1.80800790
153Chromsome breakage (HP:0040012)1.80765304
154Thrombophlebitis (HP:0004418)1.80693021
155Craniofacial hyperostosis (HP:0004493)1.79995837
156Ectopic kidney (HP:0000086)1.79689568
157Autoimmune thrombocytopenia (HP:0001973)1.79161894
158Frequent falls (HP:0002359)1.77632192
159Abnormal biliary tract physiology (HP:0012439)1.76656914
160Bile duct proliferation (HP:0001408)1.76656914
161Abnormality of dental color (HP:0011073)1.76502457
162Polydipsia (HP:0001959)1.76174646
163Abnormal drinking behavior (HP:0030082)1.76174646
164Gastrointestinal atresia (HP:0002589)1.76121221
165Abnormality of the preputium (HP:0100587)1.74485326
166Abnormality of transition element cation homeostasis (HP:0011030)1.74175635
167Short hallux (HP:0010109)1.74101082
168Tapered finger (HP:0001182)1.73898660
169Stroke (HP:0001297)1.73762132
170Chorioretinal coloboma (HP:0000567)1.73562680
171Irritability (HP:0000737)1.72800907
172Enlarged kidneys (HP:0000105)1.71645356
173Spastic tetraparesis (HP:0001285)1.71596863
174Pseudobulbar signs (HP:0002200)1.71182654
175Labial hypoplasia (HP:0000066)1.71053604
176Abnormality of renin-angiotensin system (HP:0000847)1.70387721
177Germ cell neoplasia (HP:0100728)1.69912461
178Symptomatic seizures (HP:0011145)1.69238893
179Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.68845496
180Paraplegia (HP:0010550)1.68771151
181Abnormal biliary tract morphology (HP:0012440)1.68261121
182Abnormality of iron homeostasis (HP:0011031)1.65895276
183Pancreatitis (HP:0001733)1.65512304
184Duplicated collecting system (HP:0000081)1.64488691
185Optic nerve hypoplasia (HP:0000609)1.64466096
186Abnormal enzyme/coenzyme activity (HP:0012379)1.64393816
187Pili torti (HP:0003777)1.64012165
188Reticulocytosis (HP:0001923)1.63410404
189Hyperuricemia (HP:0002149)1.63166714
190Increased purine levels (HP:0004368)1.63166714
191Pigmentary retinal degeneration (HP:0001146)1.61968413
192Global brain atrophy (HP:0002283)1.60889669
193Right ventricular cardiomyopathy (HP:0011663)1.59768951
194Long toe (HP:0010511)1.56260524

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK36.15837540
2LATS14.54643255
3TAOK34.18795219
4ERN13.29407408
5SIK13.14277709
6PINK12.79876002
7ERBB42.62915772
8FGFR42.60123217
9TRIB32.57590890
10ZAK2.41569465
11MST1R2.38816742
12CDK122.38291227
13FER2.36611317
14INSRR2.19171294
15YES12.15408086
16TXK2.12522014
17STK392.08692165
18STK241.87446996
19ACVR1B1.81665192
20EIF2AK31.80684392
21PTK61.80059544
22FRK1.76480810
23MST41.76022217
24CAMK1D1.74074067
25RIPK11.71505123
26STK38L1.69911208
27STK31.69887064
28BLK1.67501258
29BCKDK1.66602143
30BMPR1B1.59177115
31PKN21.59029560
32TTK1.57409408
33MET1.56207047
34MAP3K101.53229964
35FGFR21.51769733
36CAMK1G1.45734444
37TRPM71.41051012
38PBK1.33004038
39TYK21.32519566
40MAP3K21.30035038
41OXSR11.29105207
42LATS21.28738536
43CASK1.27592392
44MAPKAPK31.23793763
45CDK61.21524238
46KSR21.17354859
47CDK91.15506804
48NUAK11.15135536
49EPHB11.13292575
50EPHA21.12239966
51PRKAA21.10705478
52ERBB21.10294798
53MAP3K61.07721470
54SGK31.07475197
55NEK11.07050224
56MAPK111.06679772
57BRSK21.06607296
58JAK11.05701729
59PRKD31.04352453
60IRAK11.04188950
61TGFBR11.02139592
62STK101.00180391
63FGFR30.99887681
64RET0.99785614
65MTOR0.99676306
66GRK10.98402628
67PTK20.96883790
68EPHA30.95257018
69JAK20.95136153
70NEK90.94581175
71WNK40.92020502
72TIE10.91688966
73LMTK20.91334217
74MKNK10.90947580
75MAP3K30.90901985
76EIF2AK20.90275940
77PRKAA10.88857417
78PDGFRA0.87669185
79TAOK10.87452857
80MELK0.85282801
81SGK20.84324320
82CHUK0.83562208
83CHEK20.83233558
84TBK10.82438614
85MKNK20.81844617
86PDGFRB0.81529894
87MAPKAPK50.79300030
88ADRBK20.78753367
89ICK0.77348596
90BMX0.74904694
91MAP3K130.74572552
92ERBB30.73400984
93KDR0.71862726
94NTRK30.70787129
95TRIM280.69553162
96ABL20.68649349
97WEE10.68514422
98DYRK1B0.67499318
99STK380.67344928
100DAPK20.66904426
101MAP2K40.65369076
102MAP3K90.64079492
103PLK40.63589317
104MAP3K10.62972215
105MAP3K40.62365402
106DMPK0.62192794
107TNIK0.60257735
108MAP3K70.58910797
109FGFR10.58180426
110PRKCE0.57058000
111NEK20.56533743
112ADRBK10.54208512
113ABL10.54127864
114MAP3K140.52883976
115TYRO30.52795812
116CSK0.52523509
117NLK0.51885446
118GSK3A0.51443877
119EGFR0.51402270
120FLT30.51341506
121JAK30.49667268
122BCR0.49431271
123PLK10.47463208
124IKBKE0.46515172
125TGFBR20.46149338
126MAP3K50.45864312
127PNCK0.45829127
128PIK3CA0.45827688
129IRAK30.45647322
130CDK40.44952550
131PDPK10.44857933
132MAP2K20.44276750
133BRD40.44268871
134AKT30.43869395
135EEF2K0.43152675
136MAP2K10.43103509
137MAP3K80.42559968
138LRRK20.42558798
139EPHB20.41614786
140PLK30.41581947
141PRKCZ0.41373424
142IGF1R0.41369758
143SGK2230.40080906
144SGK4940.40080906
145PRKCH0.38385713
146RPS6KB20.37786051
147PRKCQ0.36025471
148CSNK1G10.33072116
149PRKG10.32400873
150MAPK130.32076583
151OBSCN0.31041533
152BUB10.30776600
153FGR0.30582251
154CSF1R0.30014908
155INSR0.27473402
156PRKCB0.27105766
157ATM0.25594194
158MUSK0.23875229
159TEC0.23683958
160PLK20.23621486
161PRKCA0.22453767
162RPS6KB10.19534364
163NEK60.18451089

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.45071812
2Primary bile acid biosynthesis_Homo sapiens_hsa001204.16709143
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.31158130
4Arginine biosynthesis_Homo sapiens_hsa002203.02815709
5Complement and coagulation cascades_Homo sapiens_hsa046102.94627100
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.81652879
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.56163570
8Tryptophan metabolism_Homo sapiens_hsa003802.50039754
9Fatty acid degradation_Homo sapiens_hsa000712.43556077
10Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.26521118
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.21679037
12Ether lipid metabolism_Homo sapiens_hsa005652.20805457
13Staphylococcus aureus infection_Homo sapiens_hsa051502.09845793
14PPAR signaling pathway_Homo sapiens_hsa033202.05685654
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.05389880
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.03599152
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.01780572
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.01514324
19Caffeine metabolism_Homo sapiens_hsa002321.98101434
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.86421985
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.86122957
22Bile secretion_Homo sapiens_hsa049761.80529532
23Fatty acid metabolism_Homo sapiens_hsa012121.79650205
24Arachidonic acid metabolism_Homo sapiens_hsa005901.78127914
25Peroxisome_Homo sapiens_hsa041461.75606723
26Histidine metabolism_Homo sapiens_hsa003401.74463730
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.73852845
28Selenocompound metabolism_Homo sapiens_hsa004501.68269937
29N-Glycan biosynthesis_Homo sapiens_hsa005101.67793839
30Non-homologous end-joining_Homo sapiens_hsa034501.66326792
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.65744501
32Chemical carcinogenesis_Homo sapiens_hsa052041.65337148
33Butanoate metabolism_Homo sapiens_hsa006501.64682720
34Fanconi anemia pathway_Homo sapiens_hsa034601.61071877
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.60699927
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.57644596
37Serotonergic synapse_Homo sapiens_hsa047261.57615039
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.56598863
39Retinol metabolism_Homo sapiens_hsa008301.52530066
40Propanoate metabolism_Homo sapiens_hsa006401.46607750
41Lysine degradation_Homo sapiens_hsa003101.44212189
42Drug metabolism - other enzymes_Homo sapiens_hsa009831.43748430
43ABC transporters_Homo sapiens_hsa020101.42363873
44Phototransduction_Homo sapiens_hsa047441.40177862
45Proteasome_Homo sapiens_hsa030501.39387979
46Nicotine addiction_Homo sapiens_hsa050331.36442242
47beta-Alanine metabolism_Homo sapiens_hsa004101.36423758
48Fat digestion and absorption_Homo sapiens_hsa049751.32723148
49ECM-receptor interaction_Homo sapiens_hsa045121.32153914
50Starch and sucrose metabolism_Homo sapiens_hsa005001.29008189
51Steroid biosynthesis_Homo sapiens_hsa001001.20481595
52RNA transport_Homo sapiens_hsa030131.20474211
53Calcium signaling pathway_Homo sapiens_hsa040201.18627332
54Salivary secretion_Homo sapiens_hsa049701.16647080
55p53 signaling pathway_Homo sapiens_hsa041151.16326233
56Sulfur metabolism_Homo sapiens_hsa009201.15317290
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.10343072
58Phenylalanine metabolism_Homo sapiens_hsa003601.07878882
59Tyrosine metabolism_Homo sapiens_hsa003501.07855999
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.06292281
61Tight junction_Homo sapiens_hsa045301.04738208
62Fatty acid biosynthesis_Homo sapiens_hsa000611.03718893
63Cysteine and methionine metabolism_Homo sapiens_hsa002701.01408460
64Pyruvate metabolism_Homo sapiens_hsa006201.00135627
65Vitamin digestion and absorption_Homo sapiens_hsa049770.99991447
66TGF-beta signaling pathway_Homo sapiens_hsa043500.99775882
67Homologous recombination_Homo sapiens_hsa034400.99221772
68Protein digestion and absorption_Homo sapiens_hsa049740.98997668
69Regulation of actin cytoskeleton_Homo sapiens_hsa048100.98883051
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.97331771
71Proteoglycans in cancer_Homo sapiens_hsa052050.97187008
72Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.96758815
73Olfactory transduction_Homo sapiens_hsa047400.96203747
74Hippo signaling pathway_Homo sapiens_hsa043900.91797173
75Folate biosynthesis_Homo sapiens_hsa007900.89994292
76cAMP signaling pathway_Homo sapiens_hsa040240.89533772
77Vitamin B6 metabolism_Homo sapiens_hsa007500.87797649
78Focal adhesion_Homo sapiens_hsa045100.86166626
79Biosynthesis of amino acids_Homo sapiens_hsa012300.84912078
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84415377
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84103682
82Glycerolipid metabolism_Homo sapiens_hsa005610.80892142
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.79449773
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79132380
85Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.77662524
86Fatty acid elongation_Homo sapiens_hsa000620.69586230
87Carbon metabolism_Homo sapiens_hsa012000.68328663
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.67820375
89Insulin resistance_Homo sapiens_hsa049310.66027841
90Arginine and proline metabolism_Homo sapiens_hsa003300.65157583
91Basal transcription factors_Homo sapiens_hsa030220.64831516
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64632756
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63401800
94Dorso-ventral axis formation_Homo sapiens_hsa043200.63125107
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59409399
96Basal cell carcinoma_Homo sapiens_hsa052170.55066929
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54619115
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53176639
99Mismatch repair_Homo sapiens_hsa034300.52839442
100Melanoma_Homo sapiens_hsa052180.52384674
101Sphingolipid metabolism_Homo sapiens_hsa006000.51165113
102Pentose phosphate pathway_Homo sapiens_hsa000300.48744894
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.48435029
104Oxytocin signaling pathway_Homo sapiens_hsa049210.47465126
105Cyanoamino acid metabolism_Homo sapiens_hsa004600.46118133
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44448435
107Pancreatic secretion_Homo sapiens_hsa049720.43777543
108RNA degradation_Homo sapiens_hsa030180.41537683
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.40923341
110Sulfur relay system_Homo sapiens_hsa041220.39460084
111Cell cycle_Homo sapiens_hsa041100.39029858
112MicroRNAs in cancer_Homo sapiens_hsa052060.38736069
113Linoleic acid metabolism_Homo sapiens_hsa005910.37788227
114Prion diseases_Homo sapiens_hsa050200.37325985
115One carbon pool by folate_Homo sapiens_hsa006700.37311291
116Wnt signaling pathway_Homo sapiens_hsa043100.36514691
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.36193668
118Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35621108
119Hedgehog signaling pathway_Homo sapiens_hsa043400.35603513
120Cholinergic synapse_Homo sapiens_hsa047250.32017989
121Glycosaminoglycan degradation_Homo sapiens_hsa005310.30927359
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29241510
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29023111
124Adherens junction_Homo sapiens_hsa045200.28402493
125Glucagon signaling pathway_Homo sapiens_hsa049220.28339730
126Glutathione metabolism_Homo sapiens_hsa004800.27637030
127Morphine addiction_Homo sapiens_hsa050320.27435748
128Base excision repair_Homo sapiens_hsa034100.26684195
129AMPK signaling pathway_Homo sapiens_hsa041520.25110049
130Ovarian steroidogenesis_Homo sapiens_hsa049130.24152150
131Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.23905792
132Pathways in cancer_Homo sapiens_hsa052000.23899495
133Axon guidance_Homo sapiens_hsa043600.23835415
134Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.23743397
135Ras signaling pathway_Homo sapiens_hsa040140.23010274
136Gastric acid secretion_Homo sapiens_hsa049710.22763217
137Mineral absorption_Homo sapiens_hsa049780.22748068
138Galactose metabolism_Homo sapiens_hsa000520.21766759
139Type II diabetes mellitus_Homo sapiens_hsa049300.19710439
140Bladder cancer_Homo sapiens_hsa052190.16445098
141Pancreatic cancer_Homo sapiens_hsa052120.13565557
142Hepatitis C_Homo sapiens_hsa051600.12777301
143Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.12351334
144Amoebiasis_Homo sapiens_hsa051460.12334300
145Metabolic pathways_Homo sapiens_hsa011000.11124579
146Insulin signaling pathway_Homo sapiens_hsa049100.10073350
147Longevity regulating pathway - mammal_Homo sapiens_hsa042110.09324964
148Lysosome_Homo sapiens_hsa041420.09271628
149Circadian rhythm_Homo sapiens_hsa047100.09125797
150Fructose and mannose metabolism_Homo sapiens_hsa000510.08181379
151Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.07911022
152Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.07339121
153Prolactin signaling pathway_Homo sapiens_hsa049170.06823712
154Malaria_Homo sapiens_hsa051440.05803402
155Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.05613984
156Small cell lung cancer_Homo sapiens_hsa052220.05279290
157Prostate cancer_Homo sapiens_hsa052150.05196986

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