FGF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)7.07636977
2axon ensheathment in central nervous system (GO:0032291)7.07636977
3synaptic vesicle docking involved in exocytosis (GO:0016081)6.39032390
4cellular potassium ion homeostasis (GO:0030007)6.03385570
5synaptic vesicle maturation (GO:0016188)5.91812362
6sodium ion export (GO:0071436)5.68731480
7glutamate secretion (GO:0014047)5.67374997
8L-amino acid import (GO:0043092)5.58070268
9membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.56431874
10synaptic vesicle exocytosis (GO:0016079)5.07199826
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.03798962
12L-phenylalanine catabolic process (GO:0006559)5.03798962
13amino acid import (GO:0043090)4.98054598
14regulation of short-term neuronal synaptic plasticity (GO:0048172)4.83436567
15L-phenylalanine metabolic process (GO:0006558)4.83233633
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.83233633
17regulation of synaptic vesicle exocytosis (GO:2000300)4.82807505
18neuronal ion channel clustering (GO:0045161)4.54377225
19positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.54277444
20potassium ion homeostasis (GO:0055075)4.52469642
21postsynaptic membrane organization (GO:0001941)4.48499907
22potassium ion import (GO:0010107)4.48439104
23locomotory exploration behavior (GO:0035641)4.27970659
24neuronal action potential propagation (GO:0019227)4.25494326
25regulation of synaptic vesicle transport (GO:1902803)4.22842814
26aromatic amino acid family catabolic process (GO:0009074)4.21124014
27lysine metabolic process (GO:0006553)4.20894463
28lysine catabolic process (GO:0006554)4.20894463
29regulation of neuronal synaptic plasticity (GO:0048168)4.19728389
30cell communication by electrical coupling (GO:0010644)4.12317474
31neurotransmitter secretion (GO:0007269)4.07572007
32cerebellar granule cell differentiation (GO:0021707)4.04037000
33ionotropic glutamate receptor signaling pathway (GO:0035235)4.03981847
34alpha-linolenic acid metabolic process (GO:0036109)3.99328297
35neurotransmitter uptake (GO:0001504)3.98105631
36vocalization behavior (GO:0071625)3.95963041
37negative regulation of synaptic transmission, GABAergic (GO:0032229)3.93092976
38presynaptic membrane organization (GO:0097090)3.90034201
39astrocyte development (GO:0014002)3.86169344
40cysteine metabolic process (GO:0006534)3.81028275
41aspartate family amino acid catabolic process (GO:0009068)3.79453598
42presynaptic membrane assembly (GO:0097105)3.78782271
43glyoxylate metabolic process (GO:0046487)3.77066280
44regulation of long-term neuronal synaptic plasticity (GO:0048169)3.71656384
45cellular sodium ion homeostasis (GO:0006883)3.68237753
46cellular ketone body metabolic process (GO:0046950)3.66122974
47neuron cell-cell adhesion (GO:0007158)3.65407924
48kynurenine metabolic process (GO:0070189)3.64602285
49regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.63583752
50short-chain fatty acid metabolic process (GO:0046459)3.63048181
51positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.62450239
52glutamate metabolic process (GO:0006536)3.60839340
53bile acid biosynthetic process (GO:0006699)3.58933036
54acidic amino acid transport (GO:0015800)3.56802308
55regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.53715747
56triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.52656394
57regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.51111384
58exploration behavior (GO:0035640)3.51044987
59synaptic transmission, glutamatergic (GO:0035249)3.50973559
60positive regulation of dendritic spine development (GO:0060999)3.49471608
61fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.49310805
62positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.49134848
63indole-containing compound catabolic process (GO:0042436)3.47093261
64indolalkylamine catabolic process (GO:0046218)3.47093261
65tryptophan catabolic process (GO:0006569)3.47093261
66positive regulation of synapse maturation (GO:0090129)3.46566028
67neurotransmitter-gated ion channel clustering (GO:0072578)3.44651748
68sulfur amino acid catabolic process (GO:0000098)3.41355022
69neurotransmitter transport (GO:0006836)3.41294458
70regulation of synapse structural plasticity (GO:0051823)3.38083067
71dicarboxylic acid biosynthetic process (GO:0043650)3.37007525
72myelination (GO:0042552)3.36519814
73regulation of voltage-gated calcium channel activity (GO:1901385)3.36405345
74acetyl-CoA metabolic process (GO:0006084)3.36288822
75coenzyme catabolic process (GO:0009109)3.34305685
76regulation of glutamate receptor signaling pathway (GO:1900449)3.32729455
77regulation of synaptic plasticity (GO:0048167)3.32408614
78neuromuscular process controlling balance (GO:0050885)3.32340171
79axon ensheathment (GO:0008366)3.30610015
80ensheathment of neurons (GO:0007272)3.30610015
812-oxoglutarate metabolic process (GO:0006103)3.24274492
82myelin maintenance (GO:0043217)3.23986867
83tryptophan metabolic process (GO:0006568)3.23280179
84gamma-aminobutyric acid signaling pathway (GO:0007214)3.22688635
85L-glutamate transport (GO:0015813)3.22233926
86gamma-aminobutyric acid transport (GO:0015812)3.22199327
87long-term synaptic potentiation (GO:0060291)3.19699451
88astrocyte differentiation (GO:0048708)3.19463190
89cellular modified amino acid catabolic process (GO:0042219)3.18923707
90ethanol oxidation (GO:0006069)3.18890373
91alpha-amino acid catabolic process (GO:1901606)3.18455510
92fatty acid beta-oxidation (GO:0006635)3.18166560
93dicarboxylic acid catabolic process (GO:0043649)3.18147507
94glutamate receptor signaling pathway (GO:0007215)3.18048910
95amino-acid betaine metabolic process (GO:0006577)3.17706305
96regulation of neurotransmitter secretion (GO:0046928)3.16351347
97ketone body metabolic process (GO:1902224)3.15968082
98regulation of neurotransmitter levels (GO:0001505)3.15833232
99regulation of excitatory postsynaptic membrane potential (GO:0060079)3.13729532
100cellular amino acid catabolic process (GO:0009063)3.13270792
101auditory behavior (GO:0031223)3.13041521
102high-density lipoprotein particle remodeling (GO:0034375)3.12099302
103neuron-neuron synaptic transmission (GO:0007270)3.11992098
104regulation of neurotransmitter transport (GO:0051588)3.11334665
105regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.11291943
106protein localization to synapse (GO:0035418)3.10960863
107neurofilament cytoskeleton organization (GO:0060052)3.10498499
108drug catabolic process (GO:0042737)3.10181273
109positive regulation of membrane potential (GO:0045838)3.09964792
110homocysteine metabolic process (GO:0050667)3.08941322
111regulation of dendritic spine development (GO:0060998)3.08015589
112regulation of cell communication by electrical coupling (GO:0010649)3.07321962
113fatty acid oxidation (GO:0019395)3.06889845
114lipid oxidation (GO:0034440)3.06507813
115drug transmembrane transport (GO:0006855)3.06381817
116fatty acid catabolic process (GO:0009062)3.04454118
117aromatic amino acid family metabolic process (GO:0009072)3.02061402
118regulation of ARF protein signal transduction (GO:0032012)3.02048297
119membrane assembly (GO:0071709)3.00019616
120bile acid metabolic process (GO:0008206)2.99460089
121monocarboxylic acid catabolic process (GO:0072329)2.99301068
122detection of calcium ion (GO:0005513)2.99178485
123serine family amino acid catabolic process (GO:0009071)2.99095737
124very long-chain fatty acid metabolic process (GO:0000038)2.98161427
125regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.96571249
126synaptic vesicle endocytosis (GO:0048488)2.95582613
127cytoskeletal anchoring at plasma membrane (GO:0007016)2.95351327
128regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.93580531
129regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.92738288
130membrane depolarization during action potential (GO:0086010)2.92525222
131regulation of cardiac muscle cell contraction (GO:0086004)2.92118598
132branched-chain amino acid catabolic process (GO:0009083)2.90348585
133positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.90014013
134protein carboxylation (GO:0018214)2.87823300
135peptidyl-glutamic acid carboxylation (GO:0017187)2.87823300
136regulation of dendritic spine morphogenesis (GO:0061001)2.87669620
137long-chain fatty acid biosynthetic process (GO:0042759)2.87498633
138tyrosine metabolic process (GO:0006570)2.87382917
139organic acid catabolic process (GO:0016054)2.87241034
140carboxylic acid catabolic process (GO:0046395)2.87241034
141regulation of triglyceride catabolic process (GO:0010896)2.87048618
142exogenous drug catabolic process (GO:0042738)2.86555682
143regulation of postsynaptic membrane potential (GO:0060078)2.86223686
144urea cycle (GO:0000050)2.86014655
145urea metabolic process (GO:0019627)2.86014655
146dendritic spine morphogenesis (GO:0060997)2.84141865
147fatty acid transmembrane transport (GO:1902001)2.83927097
148transmission of nerve impulse (GO:0019226)2.82334272
149regulation of protein activation cascade (GO:2000257)2.82167060
150complement activation, alternative pathway (GO:0006957)2.81671310
151response to mercury ion (GO:0046689)2.79781907
152response to gravity (GO:0009629)2.79532072
153regulation of cholesterol esterification (GO:0010872)2.79113781
154cerebellar Purkinje cell differentiation (GO:0021702)2.78457302
155substantia nigra development (GO:0021762)2.78038880
156long-term memory (GO:0007616)2.77904129
157regulation of synapse maturation (GO:0090128)2.77229733
158negative regulation of dendrite morphogenesis (GO:0050774)2.77004400
159negative regulation of fibrinolysis (GO:0051918)2.76881505
160macromolecular complex remodeling (GO:0034367)2.76806199
161plasma lipoprotein particle remodeling (GO:0034369)2.76806199
162protein-lipid complex remodeling (GO:0034368)2.76806199
163regulation of synaptic transmission (GO:0050804)2.76721297
164positive regulation of dendrite development (GO:1900006)2.76717626
165regulation of neurotransmitter uptake (GO:0051580)2.76687412
166reverse cholesterol transport (GO:0043691)2.75870949
167acyl-CoA biosynthetic process (GO:0071616)2.75540217
168thioester biosynthetic process (GO:0035384)2.75540217
169branched-chain amino acid metabolic process (GO:0009081)2.73919052
170fatty acid elongation (GO:0030497)2.72783521
171valine metabolic process (GO:0006573)2.70814972
172carnitine shuttle (GO:0006853)2.70112505
173thioester metabolic process (GO:0035383)2.69606077
174acyl-CoA metabolic process (GO:0006637)2.69606077
175nitrogen cycle metabolic process (GO:0071941)2.69334505
176regulation of fibrinolysis (GO:0051917)2.68376293
177regulation of complement activation (GO:0030449)2.67202094
178phosphate ion transmembrane transport (GO:0035435)2.66207579
179cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.66011926
180carnitine metabolic process (GO:0009437)2.64838313
181urate metabolic process (GO:0046415)2.62283113
182positive regulation of fatty acid beta-oxidation (GO:0032000)2.62078089
183biotin metabolic process (GO:0006768)2.61124607
184fatty-acyl-CoA biosynthetic process (GO:0046949)2.59371220
185regulation of cholesterol homeostasis (GO:2000188)2.59340051
186benzene-containing compound metabolic process (GO:0042537)2.57992062
187low-density lipoprotein particle remodeling (GO:0034374)2.55444682
188acylglycerol homeostasis (GO:0055090)2.54881746
189triglyceride homeostasis (GO:0070328)2.54881746
190succinate metabolic process (GO:0006105)2.54694396
191response to methylmercury (GO:0051597)2.53642089
192positive regulation of lipid catabolic process (GO:0050996)2.51465317
193negative regulation of protein activation cascade (GO:2000258)2.51080280
194negative regulation of sterol transport (GO:0032372)2.48410989
195negative regulation of cholesterol transport (GO:0032375)2.48410989
196cholesterol efflux (GO:0033344)2.46368714
197cell communication involved in cardiac conduction (GO:0086065)2.46069952
198small molecule catabolic process (GO:0044282)2.45986815

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.57093028
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.91691907
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.56764928
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.25951658
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.17579598
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.73160366
7* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.32616171
8EGR1_23403033_ChIP-Seq_LIVER_Mouse2.26466516
9EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.13012574
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.99773912
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.99400860
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.94736815
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.83025686
14ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.82115661
15GBX2_23144817_ChIP-Seq_PC3_Human1.80893422
16ESR2_21235772_ChIP-Seq_MCF-7_Human1.75702295
17MTF2_20144788_ChIP-Seq_MESCs_Mouse1.74809734
18EZH2_22144423_ChIP-Seq_EOC_Human1.73956716
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.63854457
20RNF2_18974828_ChIP-Seq_MESCs_Mouse1.62119004
21EZH2_18974828_ChIP-Seq_MESCs_Mouse1.62119004
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.59557857
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.55634275
24ESR1_20079471_ChIP-ChIP_T-47D_Human1.54786427
25JARID2_20075857_ChIP-Seq_MESCs_Mouse1.49360267
26TAF15_26573619_Chip-Seq_HEK293_Human1.48228374
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.47960440
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.47847566
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.42115564
30TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41564015
31JARID2_20064375_ChIP-Seq_MESCs_Mouse1.41458839
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.41431567
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38825982
34RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.37452374
35* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.37424247
36EP300_21415370_ChIP-Seq_HL-1_Mouse1.36880993
37AR_21572438_ChIP-Seq_LNCaP_Human1.35808958
38CTNNB1_20460455_ChIP-Seq_HCT116_Human1.35649192
39* FOXA2_19822575_ChIP-Seq_HepG2_Human1.35451312
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.35078513
41RING1B_27294783_Chip-Seq_ESCs_Mouse1.33133756
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.32509423
43CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.32096636
44DROSHA_22980978_ChIP-Seq_HELA_Human1.29193328
45RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.28210223
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27836979
47ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.26435280
48* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25520043
49NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22821861
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.22818656
51EZH2_27294783_Chip-Seq_ESCs_Mouse1.21424091
52WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.20958372
53NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20354113
54NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20354113
55EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.20348807
56SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19101126
57KDM2B_26808549_Chip-Seq_K562_Human1.18990257
58MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18059329
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17801385
60ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17367721
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.16649412
62YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15748779
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13231207
64* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12768845
65PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12178006
66TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.10937129
67TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08224844
68ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07692626
69OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07325231
70REST_21632747_ChIP-Seq_MESCs_Mouse1.06886288
71ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06156764
72RARG_19884340_ChIP-ChIP_MEFs_Mouse1.05774762
73TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04970493
74TET1_21490601_ChIP-Seq_MESCs_Mouse1.04709399
75MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04646713
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04313878
77AHR_22903824_ChIP-Seq_MCF-7_Human1.03888528
78REST_18959480_ChIP-ChIP_MESCs_Mouse1.03669420
79* SMAD4_21799915_ChIP-Seq_A2780_Human1.03437827
80EZH2_27304074_Chip-Seq_ESCs_Mouse1.02820367
81EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02232492
82ZNF263_19887448_ChIP-Seq_K562_Human1.01929987
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01165964
84PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00962289
85HTT_18923047_ChIP-ChIP_STHdh_Human0.99225305
86RNF2_27304074_Chip-Seq_ESCs_Mouse0.99114603
87* CLOCK_20551151_ChIP-Seq_293T_Human0.98708556
88BCAT_22108803_ChIP-Seq_LS180_Human0.98472710
89SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98426557
90PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98164591
91RING1B_27294783_Chip-Seq_NPCs_Mouse0.97860758
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97489148
93* SMAD3_21741376_ChIP-Seq_EPCs_Human0.97345384
94RARB_27405468_Chip-Seq_BRAIN_Mouse0.95141626
95ARNT_22903824_ChIP-Seq_MCF-7_Human0.93876452
96* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92950475
97* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92429063
98* SMAD3_21741376_ChIP-Seq_HESCs_Human0.91948565
99LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91616764
100* SMAD4_21741376_ChIP-Seq_HESCs_Human0.91489209
101AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91412448
102CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.90451851
103* TCF4_23295773_ChIP-Seq_U87_Human0.89442989
104* SOX2_21211035_ChIP-Seq_LN229_Gbm0.89030144
105TP53_23651856_ChIP-Seq_MEFs_Mouse0.88969565
106OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88190044
107GATA1_26923725_Chip-Seq_HPCs_Mouse0.87535134
108GATA1_22025678_ChIP-Seq_K562_Human0.86473693
109ESR1_21235772_ChIP-Seq_MCF-7_Human0.86020820
110* SMAD3_21741376_ChIP-Seq_ESCs_Human0.84428929
111AR_25329375_ChIP-Seq_VCAP_Human0.84054904
112STAT3_23295773_ChIP-Seq_U87_Human0.81671939
113TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.81640405
114* TBX20_22328084_ChIP-Seq_HEART_Mouse0.81635439
115* TBX20_22080862_ChIP-Seq_HEART_Mouse0.81635439
116DNAJC2_21179169_ChIP-ChIP_NT2_Human0.81545726
117SOX9_26525672_Chip-Seq_HEART_Mouse0.81535258
118* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.81266084
119TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.81150414
120P53_22127205_ChIP-Seq_FIBROBLAST_Human0.81061022
121TOP2B_26459242_ChIP-Seq_MCF-7_Human0.80952552
122ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80621216
123CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80573077
124CBX2_27304074_Chip-Seq_ESCs_Mouse0.80444925
125CTBP2_25329375_ChIP-Seq_LNCAP_Human0.79696827
126RXR_22108803_ChIP-Seq_LS180_Human0.79309526
127HNF4A_19822575_ChIP-Seq_HepG2_Human0.78768383
128TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.78633926
129TRIM28_21343339_ChIP-Seq_HEK293_Human0.77708833
130CTBP1_25329375_ChIP-Seq_LNCAP_Human0.77442552
131UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.77058362
132SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.76585568
133* SMAD4_21741376_ChIP-Seq_EPCs_Human0.76524199
134* P300_19829295_ChIP-Seq_ESCs_Human0.76231578
135SOX2_27498859_Chip-Seq_STOMACH_Mouse0.74560169
136NR3C1_21868756_ChIP-Seq_MCF10A_Human0.74296175
137NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.73115879
138* AR_19668381_ChIP-Seq_PC3_Human0.72988735
139CTCF_27219007_Chip-Seq_Bcells_Human0.72921505
140PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.72811380
141TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72807404
142PPAR_26484153_Chip-Seq_NCI-H1993_Human0.72769668
143* TP63_23658742_ChIP-Seq_EP156T_Human0.70292199

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.29807885
2MP0005360_urolithiasis4.92213035
3MP0005085_abnormal_gallbladder_physiolo3.98765373
4MP0005423_abnormal_somatic_nervous3.83268633
5MP0005365_abnormal_bile_salt3.55474176
6MP0008875_abnormal_xenobiotic_pharmacok3.49592445
7MP0005332_abnormal_amino_acid2.63928957
8MP0003806_abnormal_nucleotide_metabolis2.55977808
9MP0005083_abnormal_biliary_tract2.43865544
10MP0003195_calcinosis2.31458554
11MP0010329_abnormal_lipoprotein_level2.30959476
12MP0002735_abnormal_chemical_nociception2.21884915
13MP0003252_abnormal_bile_duct2.16559425
14MP0003329_amyloid_beta_deposits2.12170926
15MP0004043_abnormal_pH_regulation2.09019715
16MP0002837_dystrophic_cardiac_calcinosis2.03323389
17MP0004270_analgesia2.02694016
18MP0009840_abnormal_foam_cell2.02049731
19MP0004858_abnormal_nervous_system1.96684793
20MP0001984_abnormal_olfaction1.91552678
21MP0003879_abnormal_hair_cell1.85679950
22MP0002118_abnormal_lipid_homeostasis1.74347491
23MP0000778_abnormal_nervous_system1.73567775
24MP0001968_abnormal_touch/_nociception1.72731764
25MP0003690_abnormal_glial_cell1.69109512
26MP0004130_abnormal_muscle_cell1.60585530
27MP0004019_abnormal_vitamin_homeostasis1.58949869
28MP0002822_catalepsy1.56613461
29MP0003191_abnormal_cellular_cholesterol1.56235928
30MP0001905_abnormal_dopamine_level1.52925161
31MP0002736_abnormal_nociception_after1.52512651
32MP0001502_abnormal_circadian_rhythm1.52033815
33MP0004811_abnormal_neuron_physiology1.48296835
34MP0001177_atelectasis1.48241683
35MP0005646_abnormal_pituitary_gland1.45683811
36MP0005584_abnormal_enzyme/coenzyme_acti1.45567404
37MP0000604_amyloidosis1.44731533
38MP0003632_abnormal_nervous_system1.44505464
39MP0006276_abnormal_autonomic_nervous1.44333862
40MP0004859_abnormal_synaptic_plasticity1.43994708
41MP0002733_abnormal_thermal_nociception1.43864880
42MP0009046_muscle_twitch1.43284311
43MP0002066_abnormal_motor_capabilities/c1.42826325
44MP0002734_abnormal_mechanical_nocicepti1.41305256
45MP0002272_abnormal_nervous_system1.38417100
46MP0000751_myopathy1.36818176
47MP0002882_abnormal_neuron_morphology1.36586877
48MP0000955_abnormal_spinal_cord1.35920059
49MP0001666_abnormal_nutrient_absorption1.34892418
50MP0002557_abnormal_social/conspecific_i1.33958256
51MP0004147_increased_porphyrin_level1.33777495
52MP0000920_abnormal_myelination1.32502095
53MP0004036_abnormal_muscle_relaxation1.30311392
54MP0009643_abnormal_urine_homeostasis1.28514751
55MP0003646_muscle_fatigue1.26434971
56MP0001299_abnormal_eye_distance/1.26263394
57MP0003633_abnormal_nervous_system1.23736446
58MP0003075_altered_response_to1.22197007
59MP0005535_abnormal_body_temperature1.22026938
60MP0003656_abnormal_erythrocyte_physiolo1.21670046
61MP0002064_seizures1.21640858
62MP0003635_abnormal_synaptic_transmissio1.20758279
63MP0001970_abnormal_pain_threshold1.19731496
64MP0004215_abnormal_myocardial_fiber1.18122550
65MP0004885_abnormal_endolymph1.15208944
66MP0009780_abnormal_chondrocyte_physiolo1.13899562
67MP0001958_emphysema1.13304561
68MP0009745_abnormal_behavioral_response1.12794281
69MP0005319_abnormal_enzyme/_coenzyme1.12610531
70MP0002138_abnormal_hepatobiliary_system1.11824801
71MP0000609_abnormal_liver_physiology1.09821988
72MP0001963_abnormal_hearing_physiology1.06523911
73MP0001756_abnormal_urination1.04963597
74MP0003880_abnormal_central_pattern1.04670067
75MP0005623_abnormal_meninges_morphology1.04294965
76MP0006036_abnormal_mitochondrial_physio1.04258952
77MP0002067_abnormal_sensory_capabilities1.02959107
78MP0000747_muscle_weakness1.02453949
79MP0001486_abnormal_startle_reflex1.02198566
80MP0005551_abnormal_eye_electrophysiolog1.02019434
81MP0002909_abnormal_adrenal_gland0.99883485
82MP0002152_abnormal_brain_morphology0.99054988
83MP0001485_abnormal_pinna_reflex0.98611204
84MP0004084_abnormal_cardiac_muscle0.96024655
85MP0004742_abnormal_vestibular_system0.95842823
86MP0003631_nervous_system_phenotype0.95825807
87MP0000749_muscle_degeneration0.94131660
88MP0001765_abnormal_ion_homeostasis0.93280588
89MP0002229_neurodegeneration0.93256355
90MP0004142_abnormal_muscle_tone0.93068399
91MP0003868_abnormal_feces_composition0.90928023
92MP0001440_abnormal_grooming_behavior0.90289718
93MP0005636_abnormal_mineral_homeostasis0.90018254
94MP0005330_cardiomyopathy0.90011410
95MP0000230_abnormal_systemic_arterial0.89675437
96MP0001529_abnormal_vocalization0.88715406
97MP0002063_abnormal_learning/memory/cond0.88706190
98MP0002972_abnormal_cardiac_muscle0.88320697
99MP0002184_abnormal_innervation0.87277677
100MP0002876_abnormal_thyroid_physiology0.87250651
101MP0008569_lethality_at_weaning0.86349424
102MP0004085_abnormal_heartbeat0.85797316
103MP0000579_abnormal_nail_morphology0.85229402
104MP0005670_abnormal_white_adipose0.84402365
105MP0003137_abnormal_impulse_conducting0.83470867
106MP0008874_decreased_physiological_sensi0.82603832
107MP0008775_abnormal_heart_ventricle0.81491475
108MP0005171_absent_coat_pigmentation0.81147996
109MP0001764_abnormal_homeostasis0.80895591
110MP0003634_abnormal_glial_cell0.78722792
111MP0003186_abnormal_redox_activity0.78624876
112MP0005620_abnormal_muscle_contractility0.77685266
113MP0005666_abnormal_adipose_tissue0.76792801
114MP0010368_abnormal_lymphatic_system0.76173552
115MP0005647_abnormal_sex_gland0.76162348
116MP0002572_abnormal_emotion/affect_behav0.75545018
117MP0001501_abnormal_sleep_pattern0.74456432
118MP0002078_abnormal_glucose_homeostasis0.74202510
119MP0000569_abnormal_digit_pigmentation0.72880445
120MP0005167_abnormal_blood-brain_barrier0.72623615
121MP0004484_altered_response_of0.71262465
122MP0006138_congestive_heart_failure0.71169176
123MP0004924_abnormal_behavior0.71003449
124MP0005386_behavior/neurological_phenoty0.71003449
125MP0003787_abnormal_imprinting0.70661495
126MP0005595_abnormal_vascular_smooth0.70557452
127MP0003045_fibrosis0.70184376
128MP0002971_abnormal_brown_adipose0.69255395
129MP0002269_muscular_atrophy0.69107260
130MP0008872_abnormal_physiological_respon0.69086423
131MP0004145_abnormal_muscle_electrophysio0.68259462
132MP0003279_aneurysm0.66614751
133MP0005388_respiratory_system_phenotype0.65262422
134MP0002133_abnormal_respiratory_system0.65262422
135MP0002295_abnormal_pulmonary_circulatio0.65257381
136MP0002752_abnormal_somatic_nervous0.65135121
137MP0001348_abnormal_lacrimal_gland0.64134696
138MP0001346_abnormal_lacrimal_gland0.63307066
139MP0002638_abnormal_pupillary_reflex0.59468707
140MP0002069_abnormal_eating/drinking_beha0.58373247
141MP0005165_increased_susceptibility_to0.57962023
142MP0003705_abnormal_hypodermis_morpholog0.56864833
143MP0003950_abnormal_plasma_membrane0.56560223
144MP0004510_myositis0.56513330
145MP0000026_abnormal_inner_ear0.55760878
146MP0005166_decreased_susceptibility_to0.55328997
147MP0001986_abnormal_taste_sensitivity0.53736456
148MP0010386_abnormal_urinary_bladder0.53284491
149MP0010769_abnormal_survival0.51908364

Predicted human phenotypes

RankGene SetZ-score
1Focal seizures (HP:0007359)4.87231907
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.63296879
3Abnormality of binocular vision (HP:0011514)4.59296864
4Diplopia (HP:0000651)4.59296864
5Atonic seizures (HP:0010819)4.33163540
6Deep venous thrombosis (HP:0002625)4.22110643
7Febrile seizures (HP:0002373)4.17688092
8Ankle clonus (HP:0011448)4.02645253
9Xanthomatosis (HP:0000991)3.95534623
10Intrahepatic cholestasis (HP:0001406)3.95523195
11Epileptic encephalopathy (HP:0200134)3.92858134
12Abnormality of serine family amino acid metabolism (HP:0010894)3.71778322
13Abnormality of glycine metabolism (HP:0010895)3.71778322
14Hyperglycinuria (HP:0003108)3.70416134
15Hyperlipoproteinemia (HP:0010980)3.70335507
16Ketosis (HP:0001946)3.68382811
17Hyperammonemia (HP:0001987)3.66760369
18Hemiplegia (HP:0002301)3.65977497
19Spastic gait (HP:0002064)3.51473717
20Hyperglycinemia (HP:0002154)3.51342763
21Abnormal eating behavior (HP:0100738)3.46674013
22Gout (HP:0001997)3.38494445
23Ketoacidosis (HP:0001993)3.37691874
24Peripheral hypomyelination (HP:0007182)3.36495205
25Generalized tonic-clonic seizures (HP:0002069)3.33745091
26Obstructive sleep apnea (HP:0002870)3.31719112
27Dysmetria (HP:0001310)3.28033819
28Hemiparesis (HP:0001269)3.25120701
29Abnormality of monocarboxylic acid metabolism (HP:0010996)3.24782138
30Myokymia (HP:0002411)3.20386107
31Bundle branch block (HP:0011710)3.18080050
32Papilledema (HP:0001085)3.15189565
33Pheochromocytoma (HP:0002666)3.08618907
34Action tremor (HP:0002345)3.07134061
35Abnormality of fatty-acid metabolism (HP:0004359)3.04781002
36Truncal ataxia (HP:0002078)3.04441986
37Prolonged partial thromboplastin time (HP:0003645)2.97575150
38Absence seizures (HP:0002121)2.95573256
39Abnormality of glutamine family amino acid metabolism (HP:0010902)2.94729368
40Hypoglycemic coma (HP:0001325)2.94433054
41Ulnar claw (HP:0001178)2.90576492
42Lower limb muscle weakness (HP:0007340)2.89299032
43Progressive cerebellar ataxia (HP:0002073)2.88639322
44Complement deficiency (HP:0004431)2.83283955
45Dialeptic seizures (HP:0011146)2.79800491
46Abnormality of aspartate family amino acid metabolism (HP:0010899)2.79629722
47Termporal pattern (HP:0011008)2.77428769
48Insidious onset (HP:0003587)2.77428769
49Torticollis (HP:0000473)2.76986503
50Tetraplegia (HP:0002445)2.75662072
51Cerebral hypomyelination (HP:0006808)2.75238171
52Epidermoid cyst (HP:0200040)2.70036122
53Urinary bladder sphincter dysfunction (HP:0002839)2.67547806
54Neuroendocrine neoplasm (HP:0100634)2.66455932
55Hypoalphalipoproteinemia (HP:0003233)2.65544121
56Dysdiadochokinesis (HP:0002075)2.65125695
57Insomnia (HP:0100785)2.64599514
58Increased circulating renin level (HP:0000848)2.64278016
59Hypokalemic alkalosis (HP:0001949)2.64084380
60Megalencephaly (HP:0001355)2.63386765
61Hypobetalipoproteinemia (HP:0003563)2.58601703
62Cerebral hemorrhage (HP:0001342)2.55281303
63Neurofibrillary tangles (HP:0002185)2.53109116
64Abnormality of sulfur amino acid metabolism (HP:0004339)2.48656910
65Visual hallucinations (HP:0002367)2.47930017
66Segmental peripheral demyelination/remyelination (HP:0003481)2.45583643
67Urinary urgency (HP:0000012)2.45338134
68Aplasia involving bones of the upper limbs (HP:0009823)2.44538166
69Aplasia of the phalanges of the hand (HP:0009802)2.44538166
70Aplasia involving bones of the extremities (HP:0009825)2.44538166
71Delayed CNS myelination (HP:0002188)2.43735926
72Hypolipoproteinemia (HP:0010981)2.42303733
73Heart block (HP:0012722)2.40338258
74Metabolic acidosis (HP:0001942)2.38215680
75Clonus (HP:0002169)2.37626830
76Limb dystonia (HP:0002451)2.36367327
77Abnormality of purine metabolism (HP:0004352)2.35458611
78Abnormality of dicarboxylic acid metabolism (HP:0010995)2.34999286
79Dicarboxylic aciduria (HP:0003215)2.34999286
80Spastic tetraparesis (HP:0001285)2.34754849
81Mutism (HP:0002300)2.34693861
82Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.33581582
83Hyporeflexia of lower limbs (HP:0002600)2.33067469
84Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.32901744
85Abnormality of methionine metabolism (HP:0010901)2.32611103
86Alacrima (HP:0000522)2.32219837
87Alkalosis (HP:0001948)2.29747093
88Abnormal atrioventricular conduction (HP:0005150)2.29549007
89Supranuclear gaze palsy (HP:0000605)2.29225006
90Split foot (HP:0001839)2.27867500
91Annular pancreas (HP:0001734)2.26277497
92Depression (HP:0000716)2.25743722
93Metabolic alkalosis (HP:0200114)2.25292074
94Potter facies (HP:0002009)2.24375254
95Facial shape deformation (HP:0011334)2.24375254
96Anxiety (HP:0000739)2.23838506
97Cerebral edema (HP:0002181)2.22189981
98Lethargy (HP:0001254)2.22088490
99Hyperuricemia (HP:0002149)2.21930771
100Increased purine levels (HP:0004368)2.21930771
101Onion bulb formation (HP:0003383)2.21546224
102Rigidity (HP:0002063)2.19899243
103Hypomagnesemia (HP:0002917)2.18660700
104Focal motor seizures (HP:0011153)2.18616196
105Neuronal loss in central nervous system (HP:0002529)2.17791445
106Impaired vibration sensation in the lower limbs (HP:0002166)2.17275851
107Myoglobinuria (HP:0002913)2.15645213
108Turricephaly (HP:0000262)2.14664629
109Focal dystonia (HP:0004373)2.13817031
110Akinesia (HP:0002304)2.13814849
111Delusions (HP:0000746)2.13340248
112Fat malabsorption (HP:0002630)2.13092283
113Sensorimotor neuropathy (HP:0007141)2.13085489
114Abnormality of the common coagulation pathway (HP:0010990)2.12342290
115Abnormality of serum amino acid levels (HP:0003112)2.12082432
116Bradykinesia (HP:0002067)2.11706306
117Hyperactive renin-angiotensin system (HP:0000841)2.11323715
118Sleep apnea (HP:0010535)2.11190238
119Rapidly progressive (HP:0003678)2.09648438
120Vascular calcification (HP:0004934)2.04808025
121Scanning speech (HP:0002168)2.04558246
122Hammertoe (HP:0001765)2.04474997
123Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.04280174
124Neonatal onset (HP:0003623)2.04057709
125Craniofacial dystonia (HP:0012179)2.03096181
126Joint hemorrhage (HP:0005261)2.01356309
127Status epilepticus (HP:0002133)2.01137358
128Epileptiform EEG discharges (HP:0011182)2.01019269
129Abnormality of the lower motor neuron (HP:0002366)2.00916065
130Cerebral inclusion bodies (HP:0100314)1.99358173
131Atrial fibrillation (HP:0005110)1.99121604
132Foot dorsiflexor weakness (HP:0009027)1.98652677
133Abnormality of the corticospinal tract (HP:0002492)1.96462562
134Vomiting (HP:0002013)1.96212006
135Atrioventricular block (HP:0001678)1.96187937
136Shallow orbits (HP:0000586)1.95890812
137Abnormal gallbladder morphology (HP:0012437)1.95404900
138Apathy (HP:0000741)1.95304200
139Cholelithiasis (HP:0001081)1.93083555
140Skin nodule (HP:0200036)1.92140442
141Poor eye contact (HP:0000817)1.92116123
142Axonal loss (HP:0003447)1.91924047
143Intention tremor (HP:0002080)1.91125971
144Proximal tubulopathy (HP:0000114)1.90822774
145Primary atrial arrhythmia (HP:0001692)1.90270716
146Decreased motor nerve conduction velocity (HP:0003431)1.90081766
147Sudden death (HP:0001699)1.90069380
148Bronchomalacia (HP:0002780)1.87878384
149Ventricular fibrillation (HP:0001663)1.87818173
150Prolonged QT interval (HP:0001657)1.87705193
151Abnormality of nucleobase metabolism (HP:0010932)1.86382975
152Choreoathetosis (HP:0001266)1.85444553
153Irritability (HP:0000737)1.84405873
154Hyperbilirubinemia (HP:0002904)1.84260321
155Exercise-induced myalgia (HP:0003738)1.84192441
156Abnormality of magnesium homeostasis (HP:0004921)1.82779171
157Muscle fiber splitting (HP:0003555)1.82541217
158Syncope (HP:0001279)1.82231948
159Supraventricular tachycardia (HP:0004755)1.80866179
160Abnormality of the periventricular white matter (HP:0002518)1.80703072
161Slow progression (HP:0003677)1.80165289
162Cardiovascular calcification (HP:0011915)1.79951346
163Decreased lacrimation (HP:0000633)1.79427874
164Lower limb amyotrophy (HP:0007210)1.79198902
165Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.78834046
166Supraventricular arrhythmia (HP:0005115)1.78178192
167Amyloidosis (HP:0011034)1.77666362
168Hypercholesterolemia (HP:0003124)1.77557429
169Acute encephalopathy (HP:0006846)1.76234472
170Degeneration of the lateral corticospinal tracts (HP:0002314)1.74751635
171Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.74751635
172Overriding aorta (HP:0002623)1.74499955
173Postural instability (HP:0002172)1.74083491
174Muscle stiffness (HP:0003552)1.73565467
175Conjugated hyperbilirubinemia (HP:0002908)1.73033759
176Hyperaldosteronism (HP:0000859)1.72291436
177Abnormality of the foot musculature (HP:0001436)1.72180425
178Abnormality of the intrinsic pathway (HP:0010989)1.71122809

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.12091740
2LMTK23.51702622
3STK393.19160528
4UHMK13.18438113
5WNK42.95217315
6BCKDK2.85988378
7OXSR12.61777540
8NTRK12.40883246
9PHKG12.30213221
10PHKG22.30213221
11NTRK32.26162896
12MAP2K42.07267740
13PINK12.07174080
14WNK12.00601265
15MINK11.98930487
16SGK2231.88820467
17SGK4941.88820467
18CASK1.81575099
19EPHB11.81064058
20MAP3K41.77497949
21KSR21.72970945
22PDK31.62078029
23PDK41.62078029
24MAP3K91.60421173
25PLK21.57447942
26WNK31.51939549
27TYRO31.51139956
28SIK11.51085394
29FGFR21.41322287
30ARAF1.38994813
31TRIB31.36136886
32MAP3K21.35974854
33SGK21.33420169
34CAMK11.32527642
35LATS21.31755916
36SGK31.28927826
37PAK61.28511120
38NEK61.25486472
39FGFR41.23866992
40PRPF4B1.23209262
41RET1.18062455
42PDK21.16036731
43TIE11.14227950
44DAPK21.14028506
45MAPK131.08149398
46STK381.05334173
47PDPK11.01251212
48PAK31.00435761
49FER0.98536492
50CAMK2G0.98118777
51GRK70.96611479
52MAPK100.96403036
53MAP2K70.96342154
54MYLK0.94593916
55PDGFRA0.93648742
56CDK150.93063568
57CDK180.89240256
58INSRR0.88749464
59MAP3K70.88314604
60EPHA40.87185653
61MARK20.86379834
62DYRK1A0.84961626
63PRKD30.84943893
64ERBB40.82123714
65GRK50.82099610
66CDK11A0.81083695
67PRKD10.79945721
68DAPK10.79688150
69MUSK0.79260443
70LIMK10.78606813
71CDK140.78091649
72PRKCH0.77551431
73MAP2K10.76476337
74CAMKK10.76063727
75DMPK0.75817367
76NEK90.75127247
77OBSCN0.73768182
78MAP3K120.73730098
79ALK0.72501469
80CDK50.71301716
81CAMK2A0.68516465
82PDK10.67361299
83CAMK1G0.67004062
84PNCK0.66743886
85MAP3K10.65927703
86CAMK2D0.64940194
87NEK10.63964858
88MST1R0.63323905
89RPS6KA30.63170656
90ERN10.63085820
91STK110.62734330
92DDR20.62559761
93PTK20.61460312
94MAPKAPK50.61319592
95PRKCG0.60654608
96PKN10.60646832
97PRKAA10.60581575
98TESK10.60297504
99PRKACG0.60005723
100PIK3CA0.59801873
101PRKCE0.59231113
102STK38L0.59058502
103DAPK30.58698686
104PRKAA20.58582054
105RIPK10.58414755
106ROCK20.57926204
107MAPK120.57303250
108RIPK40.57150571
109NTRK20.56842970
110PTK2B0.55608580
111CAMK40.54720161
112PRKCZ0.53070202
113PRKG10.52394635
114ROCK10.51797375
115MAPKAPK30.51651150
116MET0.51042263
117TNK20.50752268
118CAMKK20.50508357
119CAMK1D0.50140342
120TTN0.49284151
121PRKACB0.48788410
122KSR10.48559465
123MAPK40.47810918
124PDGFRB0.47781592
125BMPR20.47657213
126SIK20.47116087
127FYN0.47115356
128PRKACA0.46974072
129ADRBK10.46173110
130TNIK0.45541822
131CAMK2B0.44785151
132EPHA30.43799475
133PAK20.41764707
134GSK3A0.40992398
135MAPK70.40728164
136CSNK1G20.40232345
137SGK10.39540178
138RAF10.39327614
139JAK20.38806348
140MOS0.38318063
141PRKCQ0.38114924
142MAP3K130.36889037
143BRSK10.36560523
144LRRK20.36313602
145PRKG20.36056406

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.32098498
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.82323742
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.74997514
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.62299118
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.58591428
6Long-term potentiation_Homo sapiens_hsa047202.56788603
7Arginine biosynthesis_Homo sapiens_hsa002202.51068004
8Fatty acid degradation_Homo sapiens_hsa000712.49679267
9Propanoate metabolism_Homo sapiens_hsa006402.48803181
10Butanoate metabolism_Homo sapiens_hsa006502.44926987
11Morphine addiction_Homo sapiens_hsa050322.41991122
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.38782703
13Amphetamine addiction_Homo sapiens_hsa050312.36723800
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.16542784
15Fatty acid metabolism_Homo sapiens_hsa012122.10005079
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.09559422
17Tryptophan metabolism_Homo sapiens_hsa003802.04087610
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.02537944
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.00372864
20Cocaine addiction_Homo sapiens_hsa050301.81885910
21Fatty acid elongation_Homo sapiens_hsa000621.81634293
22Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.79386539
23Peroxisome_Homo sapiens_hsa041461.75770333
24PPAR signaling pathway_Homo sapiens_hsa033201.73703278
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.71228712
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.67673589
27Pyruvate metabolism_Homo sapiens_hsa006201.66112245
28Bile secretion_Homo sapiens_hsa049761.65936114
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.56833106
30Cholinergic synapse_Homo sapiens_hsa047251.52480331
31cAMP signaling pathway_Homo sapiens_hsa040241.52177348
32beta-Alanine metabolism_Homo sapiens_hsa004101.50088271
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.47884923
34Oxytocin signaling pathway_Homo sapiens_hsa049211.44245441
35Complement and coagulation cascades_Homo sapiens_hsa046101.43321471
36Histidine metabolism_Homo sapiens_hsa003401.42694140
37Calcium signaling pathway_Homo sapiens_hsa040201.42654731
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30823969
39Sulfur metabolism_Homo sapiens_hsa009201.29201187
40Pentose and glucuronate interconversions_Homo sapiens_hsa000401.28180769
41Estrogen signaling pathway_Homo sapiens_hsa049151.27238901
42Phospholipase D signaling pathway_Homo sapiens_hsa040721.22302516
43Gap junction_Homo sapiens_hsa045401.20917297
44Carbon metabolism_Homo sapiens_hsa012001.19725165
45Long-term depression_Homo sapiens_hsa047301.19125151
46Chemical carcinogenesis_Homo sapiens_hsa052041.18941965
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16730865
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.15797851
49GnRH signaling pathway_Homo sapiens_hsa049121.15261447
50Phenylalanine metabolism_Homo sapiens_hsa003601.15141403
51Pancreatic secretion_Homo sapiens_hsa049721.14621024
52Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11026888
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07432183
54Tyrosine metabolism_Homo sapiens_hsa003501.07193662
55Glioma_Homo sapiens_hsa052141.05032851
56Serotonergic synapse_Homo sapiens_hsa047261.00991761
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.99350661
58Melanogenesis_Homo sapiens_hsa049160.99125454
59Fatty acid biosynthesis_Homo sapiens_hsa000610.97441023
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.95105134
61Steroid biosynthesis_Homo sapiens_hsa001000.94556951
62Starch and sucrose metabolism_Homo sapiens_hsa005000.93228441
63Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.93018728
64Arginine and proline metabolism_Homo sapiens_hsa003300.88889030
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.88205343
66Biosynthesis of amino acids_Homo sapiens_hsa012300.86575699
67Retinol metabolism_Homo sapiens_hsa008300.85876080
68ABC transporters_Homo sapiens_hsa020100.84952592
69Caffeine metabolism_Homo sapiens_hsa002320.84387344
70Glycerolipid metabolism_Homo sapiens_hsa005610.83650381
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83211983
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82249125
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.80743128
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.80610600
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80524304
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79917308
77* Rap1 signaling pathway_Homo sapiens_hsa040150.79643954
78ErbB signaling pathway_Homo sapiens_hsa040120.78677216
79Vitamin B6 metabolism_Homo sapiens_hsa007500.78292850
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76898387
81Axon guidance_Homo sapiens_hsa043600.75447750
82Vibrio cholerae infection_Homo sapiens_hsa051100.75436043
83Inositol phosphate metabolism_Homo sapiens_hsa005620.73801679
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70265923
85Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70046101
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.69788092
87Synaptic vesicle cycle_Homo sapiens_hsa047210.69414497
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68811469
89* Ras signaling pathway_Homo sapiens_hsa040140.68652787
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68243075
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67556805
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67483156
93Circadian rhythm_Homo sapiens_hsa047100.67458693
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64151926
95Oocyte meiosis_Homo sapiens_hsa041140.63031515
96ECM-receptor interaction_Homo sapiens_hsa045120.61733647
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.60586202
98Endocytosis_Homo sapiens_hsa041440.60572055
99GABAergic synapse_Homo sapiens_hsa047270.59575570
100Fat digestion and absorption_Homo sapiens_hsa049750.58229495
101Tight junction_Homo sapiens_hsa045300.57453031
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.57076942
103Vitamin digestion and absorption_Homo sapiens_hsa049770.56178194
104* MAPK signaling pathway_Homo sapiens_hsa040100.55714533
105Choline metabolism in cancer_Homo sapiens_hsa052310.54987260
106Focal adhesion_Homo sapiens_hsa045100.54579674
107Gastric acid secretion_Homo sapiens_hsa049710.54254909
108Cardiac muscle contraction_Homo sapiens_hsa042600.53420173
109Staphylococcus aureus infection_Homo sapiens_hsa051500.49668451
110VEGF signaling pathway_Homo sapiens_hsa043700.48778969
111Selenocompound metabolism_Homo sapiens_hsa004500.47567389
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47433500
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.46476381
114Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45487657
115Type II diabetes mellitus_Homo sapiens_hsa049300.45155135
116Folate biosynthesis_Homo sapiens_hsa007900.44793675
117Salivary secretion_Homo sapiens_hsa049700.44743148
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44388175
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43671178
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43661429
121Insulin secretion_Homo sapiens_hsa049110.41812964
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41555291
123Glutathione metabolism_Homo sapiens_hsa004800.41465564
124Lysine degradation_Homo sapiens_hsa003100.41121962
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.39739417
126Oxidative phosphorylation_Homo sapiens_hsa001900.38553746
127Insulin resistance_Homo sapiens_hsa049310.38359813
128Dorso-ventral axis formation_Homo sapiens_hsa043200.37843620
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37535026
130Taste transduction_Homo sapiens_hsa047420.37524130
131Glucagon signaling pathway_Homo sapiens_hsa049220.36727048
132Endometrial cancer_Homo sapiens_hsa052130.34527694
133Glutamatergic synapse_Homo sapiens_hsa047240.34498820
134Protein digestion and absorption_Homo sapiens_hsa049740.34396593
135Metabolic pathways_Homo sapiens_hsa011000.33398880
136SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32949127
137Renin secretion_Homo sapiens_hsa049240.32700776
138Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32635788
139Wnt signaling pathway_Homo sapiens_hsa043100.32288624
140Collecting duct acid secretion_Homo sapiens_hsa049660.32221961
141* Hippo signaling pathway_Homo sapiens_hsa043900.31070803
142Thyroid hormone synthesis_Homo sapiens_hsa049180.30989712
143Circadian entrainment_Homo sapiens_hsa047130.30676102
144Ovarian steroidogenesis_Homo sapiens_hsa049130.30214259
145Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30156016
146Amoebiasis_Homo sapiens_hsa051460.30005362
147Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29423769
148Prion diseases_Homo sapiens_hsa050200.29421129
149* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29242175
150Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.29134277
151Parkinsons disease_Homo sapiens_hsa050120.28605726
152Insulin signaling pathway_Homo sapiens_hsa049100.26171927
153Mineral absorption_Homo sapiens_hsa049780.25842008
154Alzheimers disease_Homo sapiens_hsa050100.25622999
155Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25459705
156AMPK signaling pathway_Homo sapiens_hsa041520.25027027
157Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.24326438
158Olfactory transduction_Homo sapiens_hsa047400.24150048
159Sulfur relay system_Homo sapiens_hsa041220.23934735
160Nicotine addiction_Homo sapiens_hsa050330.23485092
161Dopaminergic synapse_Homo sapiens_hsa047280.21809488
162Dilated cardiomyopathy_Homo sapiens_hsa054140.21641623

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »