FGF10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1skeletal muscle adaptation (GO:0043501)8.71845478
2negative regulation of stress fiber assembly (GO:0051497)7.50876637
3peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)7.33051551
4negative regulation of Rho protein signal transduction (GO:0035024)7.29776523
5camera-type eye morphogenesis (GO:0048593)6.50122617
6striated muscle hypertrophy (GO:0014897)6.48310351
7muscle hypertrophy (GO:0014896)5.77338892
8negative regulation of actin filament bundle assembly (GO:0032232)5.67479676
9bicarbonate transport (GO:0015701)5.49195063
10regulation of branching involved in prostate gland morphogenesis (GO:0060687)5.26056466
11regulation of mitochondrial depolarization (GO:0051900)5.16965277
12positive regulation of focal adhesion assembly (GO:0051894)5.16856557
13positive regulation of cell junction assembly (GO:1901890)5.16856557
14mesenchymal cell differentiation involved in kidney development (GO:0072161)5.05093127
15mesenchymal cell differentiation involved in renal system development (GO:2001012)5.05093127
16cell migration involved in heart development (GO:0060973)4.94896927
17positive regulation of adherens junction organization (GO:1903393)4.81512398
18* mesenchymal-epithelial cell signaling (GO:0060638)4.78818252
19* lateral sprouting from an epithelium (GO:0060601)4.75256160
20venous blood vessel morphogenesis (GO:0048845)4.74538514
21peptidyl-proline hydroxylation (GO:0019511)4.58864872
22bone trabecula formation (GO:0060346)4.52261856
23non-canonical Wnt signaling pathway (GO:0035567)4.51454097
24mesenchymal cell proliferation (GO:0010463)4.31250492
25negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.17475107
26striated muscle adaptation (GO:0014888)4.17288223
27* regulation of branching involved in salivary gland morphogenesis (GO:0060693)4.15752594
28cardiac muscle cell proliferation (GO:0060038)4.06647353
29cell proliferation involved in kidney development (GO:0072111)4.02298988
30* protein localization to cell surface (GO:0034394)3.95800899
31craniofacial suture morphogenesis (GO:0097094)3.94689514
32prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.93980953
33collagen catabolic process (GO:0030574)3.81781764
34establishment of nucleus localization (GO:0040023)3.80150691
35myofibril assembly (GO:0030239)3.75583931
36endocardial cushion morphogenesis (GO:0003203)3.75438004
37negative regulation of osteoblast proliferation (GO:0033689)3.70983534
38striated muscle cell proliferation (GO:0014855)3.70785339
39regulation of non-canonical Wnt signaling pathway (GO:2000050)3.70646689
40negative regulation of cell-matrix adhesion (GO:0001953)3.66405593
41collagen metabolic process (GO:0032963)3.63350264
42* mesenchymal cell differentiation (GO:0048762)3.58168662
43sequestering of extracellular ligand from receptor (GO:0035581)3.55827528
44negative regulation of catenin import into nucleus (GO:0035414)3.53536013
45protein hydroxylation (GO:0018126)3.52789306
46multicellular organismal catabolic process (GO:0044243)3.49668408
47cardiac myofibril assembly (GO:0055003)3.49367227
48cell proliferation involved in metanephros development (GO:0072203)3.46852800
49multicellular organismal macromolecule metabolic process (GO:0044259)3.45909654
50somite development (GO:0061053)3.43650976
51* limb bud formation (GO:0060174)3.42914361
52negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.42632692
53chondrocyte proliferation (GO:0035988)3.41434645
54regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.38502046
55multicellular organismal metabolic process (GO:0044236)3.35781540
56outflow tract septum morphogenesis (GO:0003148)3.35046736
57branching involved in salivary gland morphogenesis (GO:0060445)3.33115204
58muscle adaptation (GO:0043500)3.32504805
59cell differentiation involved in kidney development (GO:0061005)3.32348462
60glomerular filtration (GO:0003094)3.25359447
61muscle cell proliferation (GO:0033002)3.22881334
62epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.19526457
63collagen fibril organization (GO:0030199)3.19444906
64dermatan sulfate biosynthetic process (GO:0030208)3.18593720
65regulation of pigment cell differentiation (GO:0050932)3.16893178
66regulation of glomerulus development (GO:0090192)3.16537435
67embryonic retina morphogenesis in camera-type eye (GO:0060059)3.15565125
68glial cell migration (GO:0008347)3.15045987
69cranial suture morphogenesis (GO:0060363)3.14699214
70paraxial mesoderm development (GO:0048339)3.13439853
71embryonic forelimb morphogenesis (GO:0035115)3.12179326
72negative regulation of hormone biosynthetic process (GO:0032353)3.11733673
73cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.11312568
74cartilage morphogenesis (GO:0060536)3.09041974
75eye morphogenesis (GO:0048592)3.07843451
76* organ growth (GO:0035265)3.06741417
77branching involved in labyrinthine layer morphogenesis (GO:0060670)3.06402271
78outer ear morphogenesis (GO:0042473)3.05525437
79cell differentiation involved in metanephros development (GO:0072202)3.05144927
80myoblast fusion (GO:0007520)3.05068738
81branching involved in prostate gland morphogenesis (GO:0060442)3.03279492
82cardiac epithelial to mesenchymal transition (GO:0060317)3.02237379
83glomerulus development (GO:0032835)3.01726505
84ventricular cardiac muscle cell development (GO:0055015)3.01053520
85* mesonephros development (GO:0001823)2.99830480
86mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.99549553
87negative regulation of stem cell proliferation (GO:2000647)2.98203216
88regulation of focal adhesion assembly (GO:0051893)2.97948974
89regulation of cell-substrate junction assembly (GO:0090109)2.97948974
90mesenchyme morphogenesis (GO:0072132)2.96906521
91regulation of bile acid biosynthetic process (GO:0070857)2.96836722
92planar cell polarity pathway involved in neural tube closure (GO:0090179)2.95224830
93middle ear morphogenesis (GO:0042474)2.91346726
94hindlimb morphogenesis (GO:0035137)2.87917973
95forelimb morphogenesis (GO:0035136)2.87649360
96extracellular regulation of signal transduction (GO:1900115)2.87313969
97extracellular negative regulation of signal transduction (GO:1900116)2.87313969
98positive regulation of heart growth (GO:0060421)2.86785638
99presynaptic membrane assembly (GO:0097105)2.85746523
100regulation of adherens junction organization (GO:1903391)2.85715692
101respiratory tube development (GO:0030323)2.85479429
102renal filtration (GO:0097205)2.84237581
103dermatan sulfate metabolic process (GO:0030205)2.83908741
104relaxation of smooth muscle (GO:0044557)2.83052887
105embryonic cranial skeleton morphogenesis (GO:0048701)2.81607260
106cranial nerve morphogenesis (GO:0021602)2.81262799
107negative regulation of striated muscle cell apoptotic process (GO:0010664)2.81079902
108blood circulation (GO:0008015)2.80239245
109negative regulation of embryonic development (GO:0045992)2.77344452
110cerebral cortex radially oriented cell migration (GO:0021799)2.76982669
111cardiac muscle tissue morphogenesis (GO:0055008)2.75625556
112regulation of osteoblast proliferation (GO:0033688)2.75608595
113regulation of glucocorticoid metabolic process (GO:0031943)2.75358521
114import into cell (GO:0098657)2.75204005
115trabecula formation (GO:0060343)2.75192919
116* embryonic digestive tract morphogenesis (GO:0048557)2.75185709
117pathway-restricted SMAD protein phosphorylation (GO:0060389)2.74859138
118* smooth muscle cell differentiation (GO:0051145)2.74856907
119neuron cell-cell adhesion (GO:0007158)2.73285291
120female gonad development (GO:0008585)2.72550074
121dopaminergic neuron differentiation (GO:0071542)2.71922677
122convergent extension (GO:0060026)2.71281785
123regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.71131141
124positive regulation of cardiac muscle tissue development (GO:0055025)2.70334867
125regulation of cardioblast differentiation (GO:0051890)2.69756289
126metanephric mesenchyme development (GO:0072075)2.68937923
127negative regulation of cartilage development (GO:0061037)2.68876874
128regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.68828133
129pharyngeal system development (GO:0060037)2.68517356
130* embryonic camera-type eye development (GO:0031076)2.68356459
131axonal fasciculation (GO:0007413)2.66159734
132neuron recognition (GO:0008038)2.65839512
133bone development (GO:0060348)2.65270160
134negative regulation of hormone metabolic process (GO:0032351)2.64854998
135positive regulation of glomerulus development (GO:0090193)2.64651471
136negative regulation of smoothened signaling pathway (GO:0045879)2.64581690
137positive regulation of cardiac muscle cell proliferation (GO:0060045)2.64357829
138cell communication by electrical coupling (GO:0010644)2.62758435
139positive regulation of fat cell differentiation (GO:0045600)2.61831505
140positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)2.61496441
141regulation of mesenchymal cell proliferation (GO:0010464)2.61122279
142embryonic hindlimb morphogenesis (GO:0035116)2.61059839
143regulation of Rho protein signal transduction (GO:0035023)2.59938936
144digestive tract morphogenesis (GO:0048546)2.59689685
145pattern specification involved in kidney development (GO:0061004)2.59613048
146forebrain neuron development (GO:0021884)2.58945353
147positive regulation of stress fiber assembly (GO:0051496)2.58137482
148peripheral nervous system axon ensheathment (GO:0032292)2.57968483
149myelination in peripheral nervous system (GO:0022011)2.57968483
150negative regulation of axon extension involved in axon guidance (GO:0048843)2.57752159
151presynaptic membrane organization (GO:0097090)2.57163481
152syncytium formation by plasma membrane fusion (GO:0000768)2.57016222
153embryonic appendage morphogenesis (GO:0035113)2.54390311
154embryonic limb morphogenesis (GO:0030326)2.54390311
155neuron projection extension involved in neuron projection guidance (GO:1902284)2.53478303
156axon extension involved in axon guidance (GO:0048846)2.53478303
157lung-associated mesenchyme development (GO:0060484)2.53186833
158positive regulation of synapse assembly (GO:0051965)2.53039164
159cardiac muscle cell development (GO:0055013)2.52757245
160axon ensheathment in central nervous system (GO:0032291)2.52723321
161central nervous system myelination (GO:0022010)2.52723321
162central nervous system projection neuron axonogenesis (GO:0021952)2.50865098
163muscle tissue morphogenesis (GO:0060415)2.50568057
164positive regulation of cardiac muscle tissue growth (GO:0055023)2.50501635
165kidney mesenchyme development (GO:0072074)2.50262134
166regulation of cardiac muscle cell proliferation (GO:0060043)2.49666138
167proximal/distal pattern formation (GO:0009954)2.48599755
168extracellular matrix disassembly (GO:0022617)2.48500795
169neural crest cell development (GO:0014032)2.48010725
170nucleus localization (GO:0051647)2.46337612
171regulation of mesoderm development (GO:2000380)2.45480370
172lymph vessel development (GO:0001945)2.45171766
173mesonephric tubule development (GO:0072164)2.45011753
174cell surface receptor signaling pathway involved in heart development (GO:0061311)2.44967714
175negative regulation of systemic arterial blood pressure (GO:0003085)2.44872405
176* regulation of smoothened signaling pathway (GO:0008589)2.44579166
177regulation of membrane depolarization (GO:0003254)2.44269851
178neuronal ion channel clustering (GO:0045161)2.44081979
179ureteric bud development (GO:0001657)2.43836056
180positive regulation of mesenchymal cell proliferation (GO:0002053)2.43460845
181cellular response to epinephrine stimulus (GO:0071872)2.43303569
182artery smooth muscle contraction (GO:0014824)2.43221941
183head development (GO:0060322)2.42893342
184glomerular basement membrane development (GO:0032836)13.1020441

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.35298477
2EZH2_22144423_ChIP-Seq_EOC_Human3.32281051
3EED_16625203_ChIP-ChIP_MESCs_Mouse3.13098116
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.89504098
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.88634919
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.79209563
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.77934324
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.74812548
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.71389638
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.69956196
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.68776165
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.67104628
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.67104628
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.57923855
15* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55060902
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.41453736
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.35651831
18PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.33940324
19* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.31854812
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.31846251
21RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.22547631
22CBX2_27304074_Chip-Seq_ESCs_Mouse2.22214555
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.10516759
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.02150007
25TAF15_26573619_Chip-Seq_HEK293_Human1.93967545
26MTF2_20144788_ChIP-Seq_MESCs_Mouse1.93337576
27VDR_22108803_ChIP-Seq_LS180_Human1.89231626
28* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.88122958
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82265286
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.80024974
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.74579528
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.74246031
33P300_19829295_ChIP-Seq_ESCs_Human1.73251695
34AR_21572438_ChIP-Seq_LNCaP_Human1.72435472
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.71876498
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.71134995
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66318388
38FUS_26573619_Chip-Seq_HEK293_Human1.65861344
39WT1_19549856_ChIP-ChIP_CCG9911_Human1.64598805
40* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.64078990
41* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62903331
42SMAD3_21741376_ChIP-Seq_HESCs_Human1.61955996
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.61132272
44POU5F1_16153702_ChIP-ChIP_HESCs_Human1.60728290
45* SMAD4_21799915_ChIP-Seq_A2780_Human1.58298378
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.56829091
47TCF4_18268006_ChIP-ChIP_LS174T_Human1.56769597
48TP53_18474530_ChIP-ChIP_U2OS_Human1.55500341
49CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.54503522
50* SMAD3_21741376_ChIP-Seq_EPCs_Human1.53565727
51ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.51926460
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51520662
53RNF2_27304074_Chip-Seq_NSC_Mouse1.46354520
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45209445
55ESR1_20079471_ChIP-ChIP_T-47D_Human1.44982351
56CTNNB1_20460455_ChIP-Seq_HCT116_Human1.44754208
57* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43754268
58* TP53_20018659_ChIP-ChIP_R1E_Mouse1.40940475
59* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40298803
60HIF1A_21447827_ChIP-Seq_MCF-7_Human1.38057235
61KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.36251447
62KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.36251447
63KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.36251447
64* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35460416
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34864351
66ER_23166858_ChIP-Seq_MCF-7_Human1.32993184
67SMAD4_21741376_ChIP-Seq_HESCs_Human1.31206070
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30783634
69FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.30063390
70CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29714828
71RING1B_27294783_Chip-Seq_NPCs_Mouse1.29437623
72EP300_21415370_ChIP-Seq_HL-1_Mouse1.27158614
73TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.25812168
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.25297813
75UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24701167
76* RING1B_27294783_Chip-Seq_ESCs_Mouse1.24163640
77* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.23714981
78AHR_22903824_ChIP-Seq_MCF-7_Human1.23322251
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.21836293
80CJUN_26792858_Chip-Seq_BT549_Human1.21796706
81CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.19324390
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18677242
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18108152
84* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.17169396
85WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16757552
86IGF1R_20145208_ChIP-Seq_DFB_Human1.15869469
87SALL1_21062744_ChIP-ChIP_HESCs_Human1.15338177
88RUNX2_22187159_ChIP-Seq_PCA_Human1.14286213
89CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.13236502
90PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12545117
91GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12276509
92TP63_19390658_ChIP-ChIP_HaCaT_Human1.12133270
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11710422
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11710422
95EGR1_19032775_ChIP-ChIP_M12_Human1.11413516
96* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10618124
97CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10503583
98* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.10030170
99PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09686576
100MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.09581302
101RARG_19884340_ChIP-ChIP_MEFs_Mouse1.08085170
102TP63_17297297_ChIP-ChIP_HaCaT_Human1.07649304
103DROSHA_22980978_ChIP-Seq_HELA_Human1.07189246
104* STAT3_23295773_ChIP-Seq_U87_Human1.07122442
105PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06819502
106* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06016478
107RXR_22108803_ChIP-Seq_LS180_Human1.05868266
108BCAT_22108803_ChIP-Seq_LS180_Human1.05793888
109* SOX2_21211035_ChIP-Seq_LN229_Gbm1.05230377
110ESR1_21235772_ChIP-Seq_MCF-7_Human1.04357135
111NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.04028435
112EWS_26573619_Chip-Seq_HEK293_Human1.03864536
113IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03657850
114EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03322484
115* ISL1_27105846_Chip-Seq_CPCs_Mouse1.03179222
116E2F1_18555785_Chip-Seq_ESCs_Mouse1.02593666
117NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02126166
118HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01444752
119* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00476470
120* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00476470
121AR_25329375_ChIP-Seq_VCAP_Human1.00260282
122TP53_16413492_ChIP-PET_HCT116_Human0.99659045
123SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99427601
124LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99161680
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98940131
126FLI1_27457419_Chip-Seq_LIVER_Mouse0.98018732
127TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97971397
128MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97918890

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004885_abnormal_endolymph3.42482066
2MP0005503_abnormal_tendon_morphology3.36555212
3MP0008438_abnormal_cutaneous_collagen3.32155278
4MP0000566_synostosis2.89442168
5MP0004272_abnormal_basement_membrane2.66279181
6* MP0009250_abnormal_appendicular_skeleto2.63101283
7MP0003136_yellow_coat_color2.62823136
8MP0002938_white_spotting2.54223751
9MP0005275_abnormal_skin_tensile2.39838475
10MP0003942_abnormal_urinary_system2.13960303
11MP0002249_abnormal_larynx_morphology2.10892906
12MP0003385_abnormal_body_wall2.07312116
13MP0004134_abnormal_chest_morphology2.06692711
14MP0001299_abnormal_eye_distance/2.01041427
15MP0000049_abnormal_middle_ear2.00725205
16MP0003880_abnormal_central_pattern1.98491243
17MP0002909_abnormal_adrenal_gland1.95132177
18MP0001346_abnormal_lacrimal_gland1.82375520
19MP0002282_abnormal_trachea_morphology1.82034786
20* MP0003938_abnormal_ear_development1.81094164
21MP0009384_cardiac_valve_regurgitation1.79735950
22* MP0003937_abnormal_limbs/digits/tail_de1.67404797
23MP0005187_abnormal_penis_morphology1.66236725
24MP0003567_abnormal_fetal_cardiomyocyte1.65816346
25MP0002009_preneoplasia1.65712631
26MP0010030_abnormal_orbit_morphology1.65226177
27MP0005508_abnormal_skeleton_morphology1.62128715
28MP0003941_abnormal_skin_development1.61827967
29MP0000428_abnormal_craniofacial_morphol1.58462723
30MP0002108_abnormal_muscle_morphology1.54024074
31MP0005171_absent_coat_pigmentation1.53086365
32MP0000537_abnormal_urethra_morphology1.52402194
33MP0001661_extended_life_span1.51699453
34MP0001756_abnormal_urination1.49915194
35MP0005257_abnormal_intraocular_pressure1.49904091
36* MP0003755_abnormal_palate_morphology1.46866703
37MP0002116_abnormal_craniofacial_bone1.45891950
38MP0006292_abnormal_olfactory_placode1.43413483
39MP0001486_abnormal_startle_reflex1.43091933
40* MP0002102_abnormal_ear_morphology1.42108550
41* MP0000762_abnormal_tongue_morphology1.41646419
42MP0000534_abnormal_ureter_morphology1.41550404
43MP0006276_abnormal_autonomic_nervous1.41176976
44MP0005623_abnormal_meninges_morphology1.40463974
45MP0000778_abnormal_nervous_system1.38510462
46MP0003878_abnormal_ear_physiology1.37034423
47MP0005377_hearing/vestibular/ear_phenot1.37034423
48MP0004084_abnormal_cardiac_muscle1.36207256
49MP0001502_abnormal_circadian_rhythm1.35435267
50MP0005409_darkened_coat_color1.34716855
51MP0003122_maternal_imprinting1.33649539
52MP0001177_atelectasis1.33604878
53MP0005367_renal/urinary_system_phenotyp1.29710061
54MP0000516_abnormal_urinary_system1.29710061
55* MP0000026_abnormal_inner_ear1.29238316
56MP0000163_abnormal_cartilage_morphology1.26956155
57MP0004381_abnormal_hair_follicle1.24865636
58* MP0002177_abnormal_outer_ear1.24536059
59* MP0005193_abnormal_anterior_eye1.21646909
60MP0001293_anophthalmia1.20351368
61MP0002089_abnormal_postnatal_growth/wei1.20316037
62MP0000647_abnormal_sebaceous_gland1.17955645
63MP0001188_hyperpigmentation1.16839755
64MP0004215_abnormal_myocardial_fiber1.16174222
65MP0000631_abnormal_neuroendocrine_gland1.15026564
66MP0002932_abnormal_joint_morphology1.14752694
67MP0004742_abnormal_vestibular_system1.13438815
68MP0002876_abnormal_thyroid_physiology1.12109623
69MP0000432_abnormal_head_morphology1.11066968
70MP0001485_abnormal_pinna_reflex1.08702179
71* MP0002109_abnormal_limb_morphology1.06775414
72MP0002233_abnormal_nose_morphology1.06082709
73MP0001501_abnormal_sleep_pattern1.06020640
74MP0004133_heterotaxia1.05546518
75* MP0002115_abnormal_skeleton_extremities1.03381558
76MP0004085_abnormal_heartbeat1.03138215
77MP0001963_abnormal_hearing_physiology1.02462789
78MP0000767_abnormal_smooth_muscle1.02122020
79* MP0003935_abnormal_craniofacial_develop1.01075384
80MP0005197_abnormal_uvea_morphology1.00400625
81MP0000462_abnormal_digestive_system1.00040940
82MP0000579_abnormal_nail_morphology0.99485082
83MP0009379_abnormal_foot_pigmentation0.99156529
84* MP0002295_abnormal_pulmonary_circulatio0.98183852
85MP0005670_abnormal_white_adipose0.92195918
86MP0002114_abnormal_axial_skeleton0.91360991
87MP0000383_abnormal_hair_follicle0.90048650
88MP0000003_abnormal_adipose_tissue0.89705725
89MP0000427_abnormal_hair_cycle0.86749939
90MP0002572_abnormal_emotion/affect_behav0.85987705
91MP0002133_abnormal_respiratory_system0.85884413
92MP0005388_respiratory_system_phenotype0.85884413
93MP0000749_muscle_degeneration0.85867145
94MP0000751_myopathy0.85399290
95MP0010368_abnormal_lymphatic_system0.85173136
96MP0005379_endocrine/exocrine_gland_phen0.84578510
97MP0008004_abnormal_stomach_pH0.83547348
98MP0009046_muscle_twitch0.83195810
99MP0005595_abnormal_vascular_smooth0.82629602
100MP0001958_emphysema0.82310334
101MP0009053_abnormal_anal_canal0.82246747
102MP0003635_abnormal_synaptic_transmissio0.81877400
103MP0002332_abnormal_exercise_endurance0.81034902
104MP0004859_abnormal_synaptic_plasticity0.80699609
105MP0002272_abnormal_nervous_system0.79930235
106MP0002098_abnormal_vibrissa_morphology0.79622730
107* MP0001340_abnormal_eyelid_morphology0.79371683
108* MP0002111_abnormal_tail_morphology0.77724863
109MP0009745_abnormal_behavioral_response0.77393958
110MP0002557_abnormal_social/conspecific_i0.77369687
111MP0002127_abnormal_cardiovascular_syste0.75390335
112MP0000230_abnormal_systemic_arterial0.75062913
113MP0005375_adipose_tissue_phenotype0.73953378
114MP0003121_genomic_imprinting0.73496032
115MP0004036_abnormal_muscle_relaxation0.72358634
116MP0002896_abnormal_bone_mineralization0.72058198
117MP0003950_abnormal_plasma_membrane0.71869122
118MP0000639_abnormal_adrenal_gland0.71836263
119MP0004043_abnormal_pH_regulation0.71118251
120MP0005330_cardiomyopathy0.71067686
121MP0005620_abnormal_muscle_contractility0.70607027
122* MP0005248_abnormal_Harderian_gland0.70505259
123MP0002972_abnormal_cardiac_muscle0.69088449
124MP0004087_abnormal_muscle_fiber0.68772265
125MP0001879_abnormal_lymphatic_vessel0.68689238
126MP0005369_muscle_phenotype0.68311863
127* MP0002697_abnormal_eye_size0.66359533
128MP0002092_abnormal_eye_morphology0.65807463
129MP0008775_abnormal_heart_ventricle0.65570885
130MP0004145_abnormal_muscle_electrophysio0.63682232
131MP0010630_abnormal_cardiac_muscle0.63277987
132MP0003879_abnormal_hair_cell0.62760670
133MP0003279_aneurysm0.60368362
134MP0004510_myositis0.59641735
135MP0003137_abnormal_impulse_conducting0.58477394
136* MP0002184_abnormal_innervation0.56896364
137MP0000733_abnormal_muscle_development0.56304409
138MP0003091_abnormal_cell_migration0.55715119
139MP0002837_dystrophic_cardiac_calcinosis0.55066360
140MP0004484_altered_response_of0.52822330
141MP0002751_abnormal_autonomic_nervous0.52745445
142MP0001984_abnormal_olfaction0.48289923
143* MP0001614_abnormal_blood_vessel0.48063287
144MP0002638_abnormal_pupillary_reflex0.48024983
145* MP0005391_vision/eye_phenotype0.47511366
146MP0001286_abnormal_eye_development0.46758856
147MP0002135_abnormal_kidney_morphology0.46472164
148MP0002113_abnormal_skeleton_development0.43038045
149* MP0002128_abnormal_blood_circulation0.41909488

Predicted human phenotypes

RankGene SetZ-score
1Glomerulonephritis (HP:0000099)9.78945865
2Nephritis (HP:0000123)7.15964569
3Aplasia of the musculature (HP:0100854)5.62394738
4Abnormality of the parietal bone (HP:0002696)5.48952926
5Nonprogressive disorder (HP:0003680)5.09619098
6Midline defect of the nose (HP:0004122)4.97168138
7Corneal dystrophy (HP:0001131)4.84059455
8Stage 5 chronic kidney disease (HP:0003774)4.08431476
9Absent phalangeal crease (HP:0006109)3.90064592
10* Corneal erosion (HP:0200020)3.85090873
11Concave nail (HP:0001598)3.83336805
12Aplasia cutis congenita (HP:0001057)3.76010873
13Hyperkalemia (HP:0002153)3.74730162
14Abnormality of the nasal septum (HP:0000419)3.67019501
15Synostosis involving the elbow (HP:0003938)3.65710099
16Humeroradial synostosis (HP:0003041)3.65710099
17Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.54462679
18Short 4th metacarpal (HP:0010044)3.54462679
19* Nasolacrimal duct obstruction (HP:0000579)3.51278499
20Heterochromia iridis (HP:0001100)3.36721762
21Keratoconus (HP:0000563)3.31703131
22Increased corneal curvature (HP:0100692)3.31703131
23Polar cataract (HP:0010696)3.29455345
24Coronal craniosynostosis (HP:0004440)3.23271080
25Abnormal finger flexion creases (HP:0006143)3.19168932
26Arterial tortuosity (HP:0005116)3.15369877
27Anterior segment dysgenesis (HP:0007700)3.10775776
28Vascular tortuosity (HP:0004948)3.09755877
29Aplasia/Hypoplasia involving the musculature (HP:0001460)3.09483787
30Shallow orbits (HP:0000586)3.05110605
31Bell-shaped thorax (HP:0001591)3.01869702
32Hematuria (HP:0000790)3.01555364
33* Abnormality of the nasolacrimal system (HP:0000614)3.00682049
34* Abnormality of the lacrimal duct (HP:0011481)2.98795660
35Trigonocephaly (HP:0000243)2.90392283
36Microglossia (HP:0000171)2.88537146
37* Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.87507314
38Aplasia/Hypoplasia of the lens (HP:0008063)2.86777786
39Congenital glaucoma (HP:0001087)2.83074754
40White forelock (HP:0002211)2.78023198
41Broad metatarsal (HP:0001783)2.77305398
42Aortic dissection (HP:0002647)2.74253683
43Cubitus valgus (HP:0002967)2.67563795
44Abnormality of the 4th metacarpal (HP:0010012)2.64709877
45Abnormality of the radial head (HP:0003995)2.64609139
46Abnormality of the labia minora (HP:0012880)2.64512172
47Abnormality of the middle phalanges of the toes (HP:0010183)2.64476601
48Aortic aneurysm (HP:0004942)2.55641355
49Patchy hypopigmentation of hair (HP:0011365)2.54880367
50Short phalanx of the thumb (HP:0009660)2.54116750
51Pterygium (HP:0001059)2.53512763
52Anteriorly placed anus (HP:0001545)2.49060717
53Sparse lateral eyebrow (HP:0005338)2.48930284
54Ridged nail (HP:0001807)2.46325443
55Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.43422358
56Abnormality of the calf musculature (HP:0001430)2.41894179
57Abnormality of the ischium (HP:0003174)2.40946651
58Supernumerary ribs (HP:0005815)2.38714525
59Morphological abnormality of the middle ear (HP:0008609)2.38474487
60Supernumerary bones of the axial skeleton (HP:0009144)2.38196708
61Septo-optic dysplasia (HP:0100842)2.37880261
62* Aplasia involving bones of the extremities (HP:0009825)2.35447660
63* Aplasia involving bones of the upper limbs (HP:0009823)2.35447660
64* Aplasia of the phalanges of the hand (HP:0009802)2.35447660
65Hyponatremia (HP:0002902)2.34247154
66Abnormality of the phalanges of the 2nd finger (HP:0009541)2.33117497
67Abnormality of the diencephalon (HP:0010662)2.32876643
68Right ventricular cardiomyopathy (HP:0011663)2.32766162
69Infantile muscular hypotonia (HP:0008947)2.29923029
70Toxemia of pregnancy (HP:0100603)2.25502118
71Nephrotic syndrome (HP:0000100)2.24722029
72Anophthalmia (HP:0000528)2.24009997
73Abnormality of the proximal phalanges of the hand (HP:0009834)2.23533641
74Anal stenosis (HP:0002025)2.22723575
75Down-sloping shoulders (HP:0200021)2.22224147
76Abnormality of the distal phalanx of the thumb (HP:0009617)2.21212612
77Short hallux (HP:0010109)2.20740601
78Symphalangism affecting the phalanges of the hand (HP:0009773)2.20737446
79Premature rupture of membranes (HP:0001788)2.20616871
80Abnormality of the anterior chamber (HP:0000593)2.19902323
81Follicular hyperkeratosis (HP:0007502)2.18933168
82Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.17710371
83Vitreoretinal degeneration (HP:0000655)2.16813227
84Calf muscle hypertrophy (HP:0008981)2.14407178
85Prominent supraorbital ridges (HP:0000336)2.13177701
86* Alacrima (HP:0000522)2.10963283
87* Conical tooth (HP:0000698)2.10709981
88Postural instability (HP:0002172)2.08894205
89Limited elbow extension (HP:0001377)2.07662611
90Bilateral microphthalmos (HP:0007633)2.05014222
91Patent foramen ovale (HP:0001655)2.04907648
92Abnormality of sodium homeostasis (HP:0010931)2.04045431
93Abnormal ciliary motility (HP:0012262)2.00417059
94Spondylolisthesis (HP:0003302)1.99919094
95Absent frontal sinuses (HP:0002688)1.97535345
96Exostoses (HP:0100777)1.97117131
97Abnormality of the upper arm (HP:0001454)1.96256970
98Long toe (HP:0010511)1.95423562
99Mesomelia (HP:0003027)1.94485880
100Fibular aplasia (HP:0002990)1.93234189
101Soft skin (HP:0000977)1.92083130
102Neoplasm of the heart (HP:0100544)1.91024611
103Hyperactive renin-angiotensin system (HP:0000841)1.90200064
104Abnormality of the axillary hair (HP:0100134)1.89704936
105Abnormality of secondary sexual hair (HP:0009888)1.89704936
106Pigmentary retinal degeneration (HP:0001146)1.89539355
107Turricephaly (HP:0000262)1.88841513
108Rectal fistula (HP:0100590)1.88581632
109Rectovaginal fistula (HP:0000143)1.88581632
110Abnormal number of incisors (HP:0011064)1.88227381
111Increased number of teeth (HP:0011069)1.86842699
112Polyphagia (HP:0002591)1.85920054
113Tracheomalacia (HP:0002779)1.85276209
114Muscle hypertrophy of the lower extremities (HP:0008968)1.84522836
115Bronchomalacia (HP:0002780)1.84393935
116Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.83819192
117Cutaneous finger syndactyly (HP:0010554)1.83686571
118Aplasia/Hypoplasia of the hallux (HP:0008362)1.83277589
119Abnormality of the 2nd finger (HP:0004100)1.82230250
120* Abnormality of incisor morphology (HP:0011063)1.82229552
121Buphthalmos (HP:0000557)1.81960885
122Long nose (HP:0003189)1.81669362
123Hypoplasia of the iris (HP:0007676)1.80588818
124Osteoarthritis (HP:0002758)1.80493948
125Patellar dislocation (HP:0002999)1.79690626
126Broad ribs (HP:0000885)1.77983861
127Choanal stenosis (HP:0000452)1.77732523
128Absent septum pellucidum (HP:0001331)1.76165154
129Abnormality of the frontal sinuses (HP:0002687)1.74888385
130Cutaneous syndactyly (HP:0012725)1.74767626
131Chin dimple (HP:0010751)1.74458008
132* Abnormality of the incisor (HP:0000676)1.74260870
133* Broad toe (HP:0001837)1.74257588
134Omphalocele (HP:0001539)1.74126049
135Hypoplastic ischia (HP:0003175)1.73120611
136Large earlobe (HP:0009748)1.73063312
137Hypoplastic nipples (HP:0002557)1.73021138
138Bladder diverticulum (HP:0000015)1.72990810
139Congenital sensorineural hearing impairment (HP:0008527)1.72673974
140* Abnormality of the middle phalanges of the hand (HP:0009833)1.71652356
141Hypophosphatemia (HP:0002148)1.71598126
142Abnormality of potassium homeostasis (HP:0011042)1.71383127
143Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.70933431
144Protruding ear (HP:0000411)1.70743214
145* Preaxial foot polydactyly (HP:0001841)1.69079891
146Broad face (HP:0000283)1.68378071
147Ectopic anus (HP:0004397)1.68032051
148Absent speech (HP:0001344)1.67666547
149Aqueductal stenosis (HP:0002410)1.67304928
150Growth hormone deficiency (HP:0000824)1.67277798
151Protrusio acetabuli (HP:0003179)1.67210941
152Short ribs (HP:0000773)1.66559228
153* Mixed hearing impairment (HP:0000410)1.66354390
154Hypoventilation (HP:0002791)1.65816588
155Adrenal hypoplasia (HP:0000835)1.65022652
156Renal tubular acidosis (HP:0001947)1.64315973
157Abnormality of the phalanges of the 5th finger (HP:0004213)1.64014885
158Nephrocalcinosis (HP:0000121)1.63978409
159* Decreased lacrimation (HP:0000633)1.63859410
160Flat capital femoral epiphysis (HP:0003370)1.62207435
161Sprengel anomaly (HP:0000912)1.61464696
162Megalocornea (HP:0000485)1.60746544
163Skin pits (HP:0100276)1.60701547
164Sudden death (HP:0001699)1.60452156
165Narrow nasal bridge (HP:0000446)1.60238571
166Mitral valve prolapse (HP:0001634)1.60144814
167Bifid scrotum (HP:0000048)1.59742826
168* Cupped ear (HP:0000378)1.59307207
169Hypoplastic toenails (HP:0001800)1.56849613
170Occipital encephalocele (HP:0002085)1.56702620

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN26.29492491
2CASK4.51230837
3DDR24.13538573
4PINK13.68090063
5FLT33.40740042
6MOS3.24572389
7FGFR22.92635874
8LATS22.89382383
9LATS12.81234988
10TGFBR22.81214155
11BCR2.22238310
12MKNK22.09547304
13RET2.04505163
14CAMK1G2.02966484
15CAMK1D1.88708271
16EPHA41.87261423
17PRPF4B1.83479921
18AKT31.82932961
19NTRK31.82544583
20FER1.80036550
21STK391.77428771
22PIK3CA1.73822832
23EPHA31.73266732
24EPHB21.71737347
25TRPM71.58077795
26PKN11.57450955
27MAPK131.49605201
28PLK21.48686627
29PNCK1.47425362
30PTK2B1.44088266
31MAP3K61.39779904
32BMPR1B1.38969607
33MKNK11.35741589
34NTRK21.35041327
35INSRR1.32132167
36PDGFRA1.28904093
37NUAK11.26897789
38TNIK1.19712400
39MARK11.17424948
40MAPKAPK51.15478540
41SIK11.13708378
42MAPK151.11792983
43PDK21.11544191
44FGR1.10831134
45PRKCE1.10115671
46OXSR11.07786230
47DYRK21.04521795
48FGFR10.99998956
49GRK50.99756222
50NEK60.99096250
51CDK30.98154581
52EIF2AK20.92165062
53ERBB40.89953630
54SGK4940.89884798
55SGK2230.89884798
56IRAK20.89304329
57MET0.89057887
58WNK10.88938395
59SGK20.88298815
60CAMK2A0.84232680
61ROCK20.80572879
62CAMK2B0.79487682
63ARAF0.79252656
64ADRBK20.79053256
65MARK30.78135235
66TNK20.77297587
67TGFBR10.76763669
68PAK30.75162315
69MELK0.74094832
70EPHB10.73872210
71PDGFRB0.73641885
72GRK70.73501398
73BMX0.72756713
74ROCK10.72128614
75PAK20.71110246
76DYRK1A0.70652091
77MYLK0.70251738
78CAMK2D0.69925228
79PRKD20.69246645
80TIE10.69157863
81CLK10.68360171
82FRK0.67830657
83CAMK10.65459238
84STK30.65240749
85WNK30.64723053
86MARK20.63973672
87PIK3CG0.63783018
88AKT20.62662026
89BMPR20.61987933
90OBSCN0.61153312
91PDK10.60886698
92MAP3K90.59595430
93CSNK1A1L0.59494201
94STK38L0.59103538
95MAP3K100.58999914
96PRKAA20.58999511
97ADRBK10.58551666
98MAPK40.58050232
99MAP2K70.58034154
100ZAK0.58015163
101GSK3A0.57244399
102CDK190.57237322
103DMPK0.55778219
104UHMK10.55433438
105PAK60.55078183
106YES10.54933903
107PRKD10.54470140
108STK380.54214980
109ACVR1B0.53938708
110CDK50.53531133
111RIPK10.53492198
112MAPK70.52374280
113GRK10.50528018
114CSNK1G10.50163488
115MST1R0.48832340
116NTRK10.47847071
117IRAK10.47222191
118CAMK2G0.45105101
119INSR0.45066174
120NEK20.44994103
121FES0.43419505
122PRKCG0.42951127
123PTK20.42269267
124MAPK120.42108932
125CSNK1G20.41868561
126PRKG10.40207966
127STK110.39782875
128NLK0.39626304
129JAK20.39059554
130PHKG20.38700060
131PHKG10.38700060
132MAP3K10.38516509
133NME10.38486558
134BLK0.37880069
135MAP3K40.37303694
136STK100.36776994
137MAP3K50.35908818
138MAP3K130.34652129
139CSNK1G30.32799847
140MAP3K70.32431730
141PRKCQ0.29775044
142SGK30.29045026
143MAP4K20.28895585
144RPS6KA50.27634431
145PRKACA0.26375904
146PAK40.26195872
147TLK10.25823245
148CDK80.24102985

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009105.58343122
2Basal cell carcinoma_Homo sapiens_hsa052173.33801837
3Hedgehog signaling pathway_Homo sapiens_hsa043403.19133650
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.17747154
5Nicotine addiction_Homo sapiens_hsa050332.35503140
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.33179687
7AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.30798412
8Axon guidance_Homo sapiens_hsa043602.25169129
9Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.13116123
10Wnt signaling pathway_Homo sapiens_hsa043102.06811039
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.99568785
12ECM-receptor interaction_Homo sapiens_hsa045121.96605167
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.87355423
14TGF-beta signaling pathway_Homo sapiens_hsa043501.79382437
15Serotonergic synapse_Homo sapiens_hsa047261.72106940
16Renin secretion_Homo sapiens_hsa049241.70103158
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.69390045
18Hippo signaling pathway_Homo sapiens_hsa043901.65884579
19Amphetamine addiction_Homo sapiens_hsa050311.60486943
20* Melanoma_Homo sapiens_hsa052181.59269910
21Long-term depression_Homo sapiens_hsa047301.59180147
22Glutamatergic synapse_Homo sapiens_hsa047241.57183981
23Melanogenesis_Homo sapiens_hsa049161.55235209
24Cocaine addiction_Homo sapiens_hsa050301.52438627
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.49422035
26Taste transduction_Homo sapiens_hsa047421.49245979
27Circadian entrainment_Homo sapiens_hsa047131.46892868
28Tryptophan metabolism_Homo sapiens_hsa003801.45098165
29Morphine addiction_Homo sapiens_hsa050321.45012069
30Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.39650299
31Fatty acid biosynthesis_Homo sapiens_hsa000611.37740059
32Salivary secretion_Homo sapiens_hsa049701.36425831
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.33884398
34Oxidative phosphorylation_Homo sapiens_hsa001901.32580017
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.32319963
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.30736928
37GABAergic synapse_Homo sapiens_hsa047271.30124698
38cAMP signaling pathway_Homo sapiens_hsa040241.29551190
39Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.28353919
40Propanoate metabolism_Homo sapiens_hsa006401.25069529
41Pyruvate metabolism_Homo sapiens_hsa006201.21099609
42Central carbon metabolism in cancer_Homo sapiens_hsa052301.18881137
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.18622873
44Calcium signaling pathway_Homo sapiens_hsa040201.16904669
45Dopaminergic synapse_Homo sapiens_hsa047281.15497402
46* Ras signaling pathway_Homo sapiens_hsa040141.13025984
47Vascular smooth muscle contraction_Homo sapiens_hsa042701.12669205
48Dilated cardiomyopathy_Homo sapiens_hsa054141.12640921
49Focal adhesion_Homo sapiens_hsa045101.11663801
50Oxytocin signaling pathway_Homo sapiens_hsa049211.11218245
51Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.09074293
52* Pathways in cancer_Homo sapiens_hsa052001.06485173
53Cholinergic synapse_Homo sapiens_hsa047251.05313366
54cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03889209
55Lysine degradation_Homo sapiens_hsa003101.03808836
56Ether lipid metabolism_Homo sapiens_hsa005651.02936824
57ErbB signaling pathway_Homo sapiens_hsa040121.02070266
58Alzheimers disease_Homo sapiens_hsa050101.02052137
59Phototransduction_Homo sapiens_hsa047441.01127114
60Proteoglycans in cancer_Homo sapiens_hsa052050.98894819
61Gap junction_Homo sapiens_hsa045400.98086584
62Adherens junction_Homo sapiens_hsa045200.97510511
63Protein digestion and absorption_Homo sapiens_hsa049740.95827609
64Prostate cancer_Homo sapiens_hsa052150.95050355
65* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.94597568
66* Rap1 signaling pathway_Homo sapiens_hsa040150.92195776
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90887946
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90466137
69Long-term potentiation_Homo sapiens_hsa047200.90362803
70Ovarian steroidogenesis_Homo sapiens_hsa049130.90017507
71Cardiac muscle contraction_Homo sapiens_hsa042600.89906891
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.87854449
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86351647
74Amoebiasis_Homo sapiens_hsa051460.86188029
75Autoimmune thyroid disease_Homo sapiens_hsa053200.84961965
76Huntingtons disease_Homo sapiens_hsa050160.84565171
77Parkinsons disease_Homo sapiens_hsa050120.84380136
78Fatty acid degradation_Homo sapiens_hsa000710.82510075
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81880147
80Collecting duct acid secretion_Homo sapiens_hsa049660.81781343
81Gastric acid secretion_Homo sapiens_hsa049710.81071091
82Arachidonic acid metabolism_Homo sapiens_hsa005900.80805226
83Bile secretion_Homo sapiens_hsa049760.80548636
84Tight junction_Homo sapiens_hsa045300.79954820
85Fatty acid elongation_Homo sapiens_hsa000620.79317395
86Inositol phosphate metabolism_Homo sapiens_hsa005620.78847112
87GnRH signaling pathway_Homo sapiens_hsa049120.77769322
88African trypanosomiasis_Homo sapiens_hsa051430.77187797
89Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.77164767
90* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76954689
91Choline metabolism in cancer_Homo sapiens_hsa052310.75042201
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74150743
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72093477
94HIF-1 signaling pathway_Homo sapiens_hsa040660.71194364
95* MAPK signaling pathway_Homo sapiens_hsa040100.69268222
96Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68946348
97Rheumatoid arthritis_Homo sapiens_hsa053230.68351634
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67701912
99MicroRNAs in cancer_Homo sapiens_hsa052060.67514958
100beta-Alanine metabolism_Homo sapiens_hsa004100.66995980
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65928261
102Linoleic acid metabolism_Homo sapiens_hsa005910.64557297
103Estrogen signaling pathway_Homo sapiens_hsa049150.64267793
104Olfactory transduction_Homo sapiens_hsa047400.63384131
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63295857
106Histidine metabolism_Homo sapiens_hsa003400.62785641
107Caffeine metabolism_Homo sapiens_hsa002320.62194666
108Sphingolipid metabolism_Homo sapiens_hsa006000.61723372
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.61433111
110Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60377066
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57151445
112Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57091255
113Carbon metabolism_Homo sapiens_hsa012000.54704269
114Insulin secretion_Homo sapiens_hsa049110.54051983
115Renal cell carcinoma_Homo sapiens_hsa052110.52982683
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47155560
117AMPK signaling pathway_Homo sapiens_hsa041520.46545364
118Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46468915
119Vibrio cholerae infection_Homo sapiens_hsa051100.46013846
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45366024
121Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44669983
122Graft-versus-host disease_Homo sapiens_hsa053320.44323479
123Glucagon signaling pathway_Homo sapiens_hsa049220.43065562
124Pancreatic secretion_Homo sapiens_hsa049720.42183267
125Small cell lung cancer_Homo sapiens_hsa052220.42098871
126Circadian rhythm_Homo sapiens_hsa047100.41843409
127Malaria_Homo sapiens_hsa051440.40565477
128Fructose and mannose metabolism_Homo sapiens_hsa000510.39487051
129Mineral absorption_Homo sapiens_hsa049780.38891313
130Butanoate metabolism_Homo sapiens_hsa006500.38844241
131Arginine and proline metabolism_Homo sapiens_hsa003300.37923689
132Dorso-ventral axis formation_Homo sapiens_hsa043200.36904568
133Arginine biosynthesis_Homo sapiens_hsa002200.35704647
134Pentose phosphate pathway_Homo sapiens_hsa000300.33879174
135Chemical carcinogenesis_Homo sapiens_hsa052040.32827764
136Glycerolipid metabolism_Homo sapiens_hsa005610.29041496
137Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.25545983
138Biosynthesis of amino acids_Homo sapiens_hsa012300.24058525
139Endometrial cancer_Homo sapiens_hsa052130.21292536

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