FGF11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this gene has not yet been determined. The expression pattern of the mouse homolog implies a role in nervous system development. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.61689437
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.31502494
3vocalization behavior (GO:0071625)5.15918928
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.05734100
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.03076972
6synaptic vesicle exocytosis (GO:0016079)4.83593395
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.80846848
8locomotory exploration behavior (GO:0035641)4.80433910
9ionotropic glutamate receptor signaling pathway (GO:0035235)4.75827640
10protein localization to synapse (GO:0035418)4.74209260
11lateral sprouting from an epithelium (GO:0060601)4.63515411
12synaptic vesicle maturation (GO:0016188)4.59383647
13regulation of glutamate receptor signaling pathway (GO:1900449)4.58113350
14neuron cell-cell adhesion (GO:0007158)4.45849977
15regulation of synaptic vesicle exocytosis (GO:2000300)4.41499642
16presynaptic membrane organization (GO:0097090)4.36973572
17synaptic vesicle docking involved in exocytosis (GO:0016081)4.32231770
18glutamate receptor signaling pathway (GO:0007215)4.29640040
19nucleobase catabolic process (GO:0046113)4.17399684
20membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.12247711
21synaptic transmission, glutamatergic (GO:0035249)4.07716281
22neurotransmitter secretion (GO:0007269)4.05678715
23regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.01455045
24cellular potassium ion homeostasis (GO:0030007)4.00055701
25glutamate secretion (GO:0014047)3.99285329
26neurotransmitter-gated ion channel clustering (GO:0072578)3.91802725
27nonmotile primary cilium assembly (GO:0035058)3.90601751
28regulation of synaptic vesicle transport (GO:1902803)3.90544817
29neuron-neuron synaptic transmission (GO:0007270)3.88685609
30exploration behavior (GO:0035640)3.87591236
31regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.85139207
32establishment of tissue polarity (GO:0007164)3.82158816
33establishment of planar polarity (GO:0001736)3.82158816
34gamma-aminobutyric acid signaling pathway (GO:0007214)3.80815351
35neuronal action potential propagation (GO:0019227)3.70563351
36gamma-aminobutyric acid transport (GO:0015812)3.67869580
37positive regulation of synapse maturation (GO:0090129)3.67862120
38postsynaptic membrane organization (GO:0001941)3.66847083
39G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.64098289
40layer formation in cerebral cortex (GO:0021819)3.63970196
41sodium ion export (GO:0071436)3.63899635
42cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.63407438
43regulation of long-term neuronal synaptic plasticity (GO:0048169)3.62969144
44behavioral response to nicotine (GO:0035095)3.62531202
45long-term memory (GO:0007616)3.62164025
46regulation of neuronal synaptic plasticity (GO:0048168)3.62040973
47regulation of synapse structural plasticity (GO:0051823)3.59781141
48regulation of excitatory postsynaptic membrane potential (GO:0060079)3.54025752
49cell communication by electrical coupling (GO:0010644)3.49560106
50innervation (GO:0060384)3.49319902
51startle response (GO:0001964)3.49070475
52calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.48852662
53negative regulation of cytosolic calcium ion concentration (GO:0051481)3.46894007
54regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.45383504
55limb bud formation (GO:0060174)3.45193640
56hemidesmosome assembly (GO:0031581)3.44386871
57membrane depolarization during action potential (GO:0086010)3.43698604
58regulation of postsynaptic membrane potential (GO:0060078)3.42701431
59synaptic vesicle endocytosis (GO:0048488)3.38047644
60neurotransmitter transport (GO:0006836)3.37394804
61long-term synaptic potentiation (GO:0060291)3.35233647
62positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.35018910
63negative regulation of synaptic transmission, GABAergic (GO:0032229)3.32868729
64positive regulation of membrane potential (GO:0045838)3.31915181
65regulation of synaptic transmission, glutamatergic (GO:0051966)3.30866539
66dendritic spine morphogenesis (GO:0060997)3.30336408
67transmission of nerve impulse (GO:0019226)3.27816459
68positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.26591632
69planar cell polarity pathway involved in neural tube closure (GO:0090179)3.25397586
70positive regulation of dendritic spine morphogenesis (GO:0061003)3.23882913
71regulation of neurotransmitter secretion (GO:0046928)3.23464272
72axon extension involved in axon guidance (GO:0048846)3.22110263
73neuron projection extension involved in neuron projection guidance (GO:1902284)3.22110263
74cerebellar Purkinje cell differentiation (GO:0021702)3.20943875
75behavioral defense response (GO:0002209)3.20724320
76behavioral fear response (GO:0001662)3.20724320
77neuron recognition (GO:0008038)3.20498513
78spinal cord development (GO:0021510)3.20409489
79paraxial mesoderm development (GO:0048339)3.20237710
80membrane hyperpolarization (GO:0060081)3.17566602
81response to pheromone (GO:0019236)3.16870470
82auditory behavior (GO:0031223)3.16482632
83regulation of synapse maturation (GO:0090128)3.16267557
84regulation of axon guidance (GO:1902667)3.14755986
85establishment of mitochondrion localization (GO:0051654)3.14563415
86synapse assembly (GO:0007416)3.11739450
87membrane depolarization (GO:0051899)3.11068630
88cellular sodium ion homeostasis (GO:0006883)3.10945958
89regulation of respiratory system process (GO:0044065)3.10720410
90striatum development (GO:0021756)3.09946998
91regulation of neurotransmitter transport (GO:0051588)3.09229179
92axon extension (GO:0048675)3.09152813
93cerebellar granule cell differentiation (GO:0021707)3.08774880
94positive regulation of neurotransmitter secretion (GO:0001956)3.08678395
95camera-type eye morphogenesis (GO:0048593)3.08005237
96dendrite morphogenesis (GO:0048813)3.07847212
97proline transport (GO:0015824)3.07168938
98positive regulation of synaptic transmission, GABAergic (GO:0032230)3.07092511
99regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.06713324
100regulation of neurotransmitter levels (GO:0001505)3.06262971
101regulation of vesicle fusion (GO:0031338)3.05414560
102positive regulation of neurotransmitter transport (GO:0051590)3.05342355
103regulation of synaptic plasticity (GO:0048167)3.05001911
104regulation of dendritic spine morphogenesis (GO:0061001)3.04016386
105prepulse inhibition (GO:0060134)3.03135612
106presynaptic membrane assembly (GO:0097105)3.01831724
107regulation of axon extension involved in axon guidance (GO:0048841)3.01370839
108response to histamine (GO:0034776)3.00559595
109response to auditory stimulus (GO:0010996)3.00232023
110negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.98652475
111fear response (GO:0042596)2.98554450
112positive regulation of dendritic spine development (GO:0060999)2.94882766
113learning (GO:0007612)2.94219895
114neuromuscular synaptic transmission (GO:0007274)2.93753422
115potassium ion homeostasis (GO:0055075)2.91798851
116retinal ganglion cell axon guidance (GO:0031290)2.91207549
117central nervous system projection neuron axonogenesis (GO:0021952)2.91014657
118positive regulation of potassium ion transmembrane transport (GO:1901381)2.90946933
119regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.90468496
120limb development (GO:0060173)2.87483485
121appendage development (GO:0048736)2.87483485
122mating behavior (GO:0007617)2.87355804
123tongue development (GO:0043586)2.86313036
124axonal fasciculation (GO:0007413)2.86054006
125neuromuscular process controlling balance (GO:0050885)2.85315329
126endothelial cell chemotaxis (GO:0035767)2.82815174
127synaptic transmission (GO:0007268)2.80846096
128cell migration in hindbrain (GO:0021535)2.80529987
129positive regulation of vascular permeability (GO:0043117)2.77621844
130proximal/distal pattern formation (GO:0009954)2.73837372
131otic vesicle formation (GO:0030916)2.72506775
132generation of neurons (GO:0048699)2.71530694
133G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.67526514
134kidney morphogenesis (GO:0060993)2.67079101
135metanephric mesenchyme development (GO:0072075)2.66117210
136ventricular trabecula myocardium morphogenesis (GO:0003222)2.64880829
137myelination in peripheral nervous system (GO:0022011)2.64285472
138peripheral nervous system axon ensheathment (GO:0032292)2.64285472
139cranial nerve morphogenesis (GO:0021602)2.60826971
140coronary vasculature morphogenesis (GO:0060977)2.60399411
141convergent extension (GO:0060026)2.59146325
142somite development (GO:0061053)2.57996671
143negative regulation of axon guidance (GO:1902668)2.57519318
144ephrin receptor signaling pathway (GO:0048013)2.56854304
145neuronal stem cell maintenance (GO:0097150)2.55859845
146positive regulation of synapse assembly (GO:0051965)2.54271512
147glycolytic process (GO:0006096)2.53245742
148synaptic transmission, cholinergic (GO:0007271)2.52433035
149keratinization (GO:0031424)2.51755041
150apical protein localization (GO:0045176)2.51552790
151dendrite development (GO:0016358)2.50302505
152cerebral cortex radially oriented cell migration (GO:0021799)2.49515954
153protein localization to cilium (GO:0061512)2.49492515
154positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.49079197
155embryonic body morphogenesis (GO:0010172)2.47327201
156positive regulation of mesonephros development (GO:0061213)2.46986376
157epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.44612258
158synapse organization (GO:0050808)2.43516367
159neuron projection extension (GO:1990138)2.42113208
160neuronal ion channel clustering (GO:0045161)2.40954176
161establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.40321327
162mitochondrion transport along microtubule (GO:0047497)2.40321327
163negative regulation of catenin import into nucleus (GO:0035414)2.39408509
164embryonic camera-type eye development (GO:0031076)2.39340033
165peripheral nervous system neuron development (GO:0048935)2.38730779
166neuron migration (GO:0001764)2.37537901
167regulation of synapse assembly (GO:0051963)2.37379949
168non-canonical Wnt signaling pathway (GO:0035567)2.37137312
169specification of organ identity (GO:0010092)2.36809329
170Notch signaling involved in heart development (GO:0061314)2.35824940
171digestive tract morphogenesis (GO:0048546)2.35637836
172intermediate filament organization (GO:0045109)2.35352150
173cell communication involved in cardiac conduction (GO:0086065)2.35331438
174cochlea morphogenesis (GO:0090103)2.34998529
175negative regulation of oligodendrocyte differentiation (GO:0048715)2.34038124
176cell surface receptor signaling pathway involved in heart development (GO:0061311)2.33884882
177Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.32353873
178homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.31428310
179neuromuscular junction development (GO:0007528)2.29629780
180body morphogenesis (GO:0010171)2.28634499
181regulation of growth hormone secretion (GO:0060123)2.27110397

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.29997466
2RBPJ_22232070_ChIP-Seq_NCS_Mouse5.16718261
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.84125628
4GBX2_23144817_ChIP-Seq_PC3_Human3.75136000
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07376724
6JARID2_20064375_ChIP-Seq_MESCs_Mouse3.06653530
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.97163511
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.74455730
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.74455730
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.61207152
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.60775923
12* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.57589189
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.53553946
14REST_21632747_ChIP-Seq_MESCs_Mouse2.46906013
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46478547
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.45016308
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.38612779
18DROSHA_22980978_ChIP-Seq_HELA_Human2.36709995
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.34066608
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.33767793
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.25500907
22* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.23294085
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.19246096
24RARB_27405468_Chip-Seq_BRAIN_Mouse2.17554824
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.09669575
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.08226075
27HIF1A_21447827_ChIP-Seq_MCF-7_Human2.00162420
28AR_21572438_ChIP-Seq_LNCaP_Human1.98047158
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.92091292
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84173647
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82484635
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81607631
33TP53_20018659_ChIP-ChIP_R1E_Mouse1.71857966
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71788380
35TP63_19390658_ChIP-ChIP_HaCaT_Human1.71393155
36POU5F1_16153702_ChIP-ChIP_HESCs_Human1.70080309
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69892088
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68971384
39SMAD4_21799915_ChIP-Seq_A2780_Human1.66879148
40TAF15_26573619_Chip-Seq_HEK293_Human1.65299493
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.63582302
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.59627705
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56196088
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.55556436
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.54758210
46EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.50617660
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.49977778
48P300_19829295_ChIP-Seq_ESCs_Human1.44769399
49NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.44640763
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42723962
51ZNF274_21170338_ChIP-Seq_K562_Hela1.41723469
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.41672854
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.40050860
54VDR_22108803_ChIP-Seq_LS180_Human1.39798961
55RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39172751
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.38659600
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36652051
58RING1B_27294783_Chip-Seq_ESCs_Mouse1.36329700
59CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.35550271
60IGF1R_20145208_ChIP-Seq_DFB_Human1.35313596
61* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.31919386
62KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.31908383
63ERG_21242973_ChIP-ChIP_JURKAT_Human1.29512212
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29161480
65WT1_19549856_ChIP-ChIP_CCG9911_Human1.28573781
66RNF2_27304074_Chip-Seq_NSC_Mouse1.28364711
67POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28068953
68SOX2_21211035_ChIP-Seq_LN229_Gbm1.27806407
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.27225269
70STAT3_23295773_ChIP-Seq_U87_Human1.27079332
71MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.26849685
72SOX2_16153702_ChIP-ChIP_HESCs_Human1.25827496
73P53_22127205_ChIP-Seq_FIBROBLAST_Human1.23915276
74AR_19668381_ChIP-Seq_PC3_Human1.23516507
75AR_25329375_ChIP-Seq_VCAP_Human1.20876347
76* RING1B_27294783_Chip-Seq_NPCs_Mouse1.20215665
77TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19250343
78* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.19058064
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17772745
80E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.17671492
81TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15596014
82NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14592363
83FUS_26573619_Chip-Seq_HEK293_Human1.14271968
84SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.14126237
85NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13921636
86TCF4_23295773_ChIP-Seq_U87_Human1.13372429
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13192031
88WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12621445
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10819563
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10819563
91SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10398843
92YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10028554
93ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07715885
94RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07484697
95* ISL1_27105846_Chip-Seq_CPCs_Mouse1.07355175
96ARNT_22903824_ChIP-Seq_MCF-7_Human1.07276036
97CTCF_27219007_Chip-Seq_Bcells_Human1.06592215
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05834794
99AHR_22903824_ChIP-Seq_MCF-7_Human1.04682967
100GATA1_26923725_Chip-Seq_HPCs_Mouse1.03387709
101ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02731928
102POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.02589379
103TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01108595
104CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00546960
105TP53_16413492_ChIP-PET_HCT116_Human1.00538435
106STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00269332
107VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00223121
108MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99564033
109SMAD3_21741376_ChIP-Seq_HESCs_Human0.99384815
110POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98878903
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98707479
112SMAD4_21741376_ChIP-Seq_HESCs_Human0.98667006
113RUNX2_22187159_ChIP-Seq_PCA_Human0.98015603
114RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97305997
115PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95863996
116UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94642639
117* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.94487574
118TBX3_20139965_ChIP-Seq_MESCs_Mouse0.94269980
119DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94059658
120TP53_18474530_ChIP-ChIP_U2OS_Human0.94051276
121TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93905478
122PRDM14_20953172_ChIP-Seq_ESCs_Human0.93889266
123TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93752252
124TBX3_20139965_ChIP-Seq_ESCs_Mouse0.93712295
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93487360
126SMAD3_21741376_ChIP-Seq_ESCs_Human0.90155909
127TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89559856
128NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.89443307
129LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88907093
130NANOG_18555785_Chip-Seq_ESCs_Mouse0.88780393
131ER_23166858_ChIP-Seq_MCF-7_Human0.88322887
132SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.87817867
133ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.86670310
134MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86617876
135MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.85114856
136TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.84665766

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.29485465
2MP0003880_abnormal_central_pattern3.91050024
3MP0003635_abnormal_synaptic_transmissio3.81464921
4MP0000579_abnormal_nail_morphology3.71138421
5MP0004270_analgesia3.21565422
6MP0005377_hearing/vestibular/ear_phenot3.19795928
7MP0003878_abnormal_ear_physiology3.19795928
8MP0009745_abnormal_behavioral_response3.06359426
9MP0002063_abnormal_learning/memory/cond3.02129245
10MP0009046_muscle_twitch3.00267545
11MP0002064_seizures2.82515288
12MP0005423_abnormal_somatic_nervous2.69566492
13MP0002572_abnormal_emotion/affect_behav2.67153730
14MP0001486_abnormal_startle_reflex2.65110688
15MP0001968_abnormal_touch/_nociception2.61124253
16MP0002272_abnormal_nervous_system2.53200289
17MP0002822_catalepsy2.53064922
18MP0000566_synostosis2.52357492
19MP0008789_abnormal_olfactory_epithelium2.45693239
20MP0010030_abnormal_orbit_morphology2.36315730
21MP0001501_abnormal_sleep_pattern2.34084557
22MP0002734_abnormal_mechanical_nocicepti2.30625419
23MP0003136_yellow_coat_color2.28612464
24MP0002735_abnormal_chemical_nociception2.25270813
25MP0005551_abnormal_eye_electrophysiolog2.24181871
26MP0002736_abnormal_nociception_after2.09267046
27MP0001502_abnormal_circadian_rhythm2.03454952
28MP0002067_abnormal_sensory_capabilities2.01158912
29MP0002184_abnormal_innervation1.99727450
30MP0001440_abnormal_grooming_behavior1.97643664
31MP0000762_abnormal_tongue_morphology1.95441474
32MP0005646_abnormal_pituitary_gland1.93027881
33MP0002557_abnormal_social/conspecific_i1.87083838
34MP0000778_abnormal_nervous_system1.85887204
35MP0008569_lethality_at_weaning1.84899576
36MP0003787_abnormal_imprinting1.80962674
37MP0006276_abnormal_autonomic_nervous1.74767311
38MP0006072_abnormal_retinal_apoptosis1.73375071
39MP0001984_abnormal_olfaction1.71289087
40MP0001970_abnormal_pain_threshold1.68214807
41MP0009780_abnormal_chondrocyte_physiolo1.66855802
42MP0005386_behavior/neurological_phenoty1.66808237
43MP0004924_abnormal_behavior1.66808237
44MP0001188_hyperpigmentation1.64230778
45MP0002733_abnormal_thermal_nociception1.63055014
46MP0005645_abnormal_hypothalamus_physiol1.61490179
47MP0002233_abnormal_nose_morphology1.59452041
48MP0002638_abnormal_pupillary_reflex1.55146065
49MP0006292_abnormal_olfactory_placode1.54932817
50MP0000955_abnormal_spinal_cord1.54846974
51MP0002697_abnormal_eye_size1.54601864
52MP0002882_abnormal_neuron_morphology1.54207420
53MP0001299_abnormal_eye_distance/1.53995274
54MP0000049_abnormal_middle_ear1.53293265
55MP0004858_abnormal_nervous_system1.52451736
56MP0003755_abnormal_palate_morphology1.52300478
57MP0004885_abnormal_endolymph1.51125722
58MP0002909_abnormal_adrenal_gland1.51095962
59MP0003938_abnormal_ear_development1.50623497
60MP0004811_abnormal_neuron_physiology1.49629983
61MP0002102_abnormal_ear_morphology1.48701667
62MP0004133_heterotaxia1.47838471
63MP0003937_abnormal_limbs/digits/tail_de1.46009292
64MP0003879_abnormal_hair_cell1.44176116
65MP0004142_abnormal_muscle_tone1.35012423
66MP0003315_abnormal_perineum_morphology1.34654528
67MP0004145_abnormal_muscle_electrophysio1.34217491
68MP0000537_abnormal_urethra_morphology1.33951862
69MP0003122_maternal_imprinting1.33871714
70MP0002066_abnormal_motor_capabilities/c1.32081017
71MP0000751_myopathy1.31407474
72MP0004233_abnormal_muscle_weight1.29265697
73MP0005248_abnormal_Harderian_gland1.26450198
74MP0003385_abnormal_body_wall1.25790064
75MP0004272_abnormal_basement_membrane1.25566672
76MP0005253_abnormal_eye_physiology1.25197466
77MP0010386_abnormal_urinary_bladder1.24504723
78MP0001485_abnormal_pinna_reflex1.23155317
79MP0002090_abnormal_vision1.20124996
80MP0003567_abnormal_fetal_cardiomyocyte1.17996972
81MP0000631_abnormal_neuroendocrine_gland1.15366937
82MP0002229_neurodegeneration1.14620815
83MP0002152_abnormal_brain_morphology1.14107513
84MP0003119_abnormal_digestive_system1.13324789
85MP0004085_abnormal_heartbeat1.13003203
86MP0001529_abnormal_vocalization1.12443282
87MP0005187_abnormal_penis_morphology1.12230541
88MP0000467_abnormal_esophagus_morphology1.10786306
89MP0002938_white_spotting1.10651953
90MP0002752_abnormal_somatic_nervous1.09821378
91MP0003329_amyloid_beta_deposits1.09546310
92MP0004742_abnormal_vestibular_system1.08064294
93MP0002234_abnormal_pharynx_morphology1.07353347
94MP0003633_abnormal_nervous_system1.06693833
95MP0001293_anophthalmia1.06459157
96MP0005409_darkened_coat_color1.05168214
97MP0001286_abnormal_eye_development1.05032013
98MP0002249_abnormal_larynx_morphology1.04867303
99MP0002098_abnormal_vibrissa_morphology1.03296912
100MP0003935_abnormal_craniofacial_develop1.02878258
101MP0002837_dystrophic_cardiac_calcinosis1.01256890
102MP0003942_abnormal_urinary_system1.00631320
103MP0004215_abnormal_myocardial_fiber0.99302185
104MP0001963_abnormal_hearing_physiology0.97866476
105MP0002751_abnormal_autonomic_nervous0.97565347
106MP0004084_abnormal_cardiac_muscle0.96755612
107MP0005257_abnormal_intraocular_pressure0.96424253
108MP0003121_genomic_imprinting0.95324269
109MP0005195_abnormal_posterior_eye0.95300280
110MP0002116_abnormal_craniofacial_bone0.94232437
111MP0003137_abnormal_impulse_conducting0.93492762
112MP0003941_abnormal_skin_development0.92919524
113MP0003631_nervous_system_phenotype0.91145312
114MP0003634_abnormal_glial_cell0.90382329
115MP0002069_abnormal_eating/drinking_beha0.89571943
116MP0000383_abnormal_hair_follicle0.89317669
117MP0009250_abnormal_appendicular_skeleto0.88264957
118MP0002111_abnormal_tail_morphology0.87037025
119MP0002081_perinatal_lethality0.85228016
120MP0000534_abnormal_ureter_morphology0.83340253
121MP0005275_abnormal_skin_tensile0.82210496
122MP0000516_abnormal_urinary_system0.81856424
123MP0005367_renal/urinary_system_phenotyp0.81856424
124MP0009379_abnormal_foot_pigmentation0.81528891
125MP0000678_abnormal_parathyroid_gland0.81150826
126MP0001879_abnormal_lymphatic_vessel0.80380394
127MP0009053_abnormal_anal_canal0.78982429
128MP0005499_abnormal_olfactory_system0.78270347
129MP0005394_taste/olfaction_phenotype0.78270347
130MP0000647_abnormal_sebaceous_gland0.76954390
131MP0004484_altered_response_of0.75630592
132MP0001905_abnormal_dopamine_level0.74817585
133MP0003690_abnormal_glial_cell0.73889492
134MP0003632_abnormal_nervous_system0.73808051
135MP0003646_muscle_fatigue0.72983712
136MP0001177_atelectasis0.70748054
137MP0000569_abnormal_digit_pigmentation0.68455858
138MP0003861_abnormal_nervous_system0.68314349
139MP0000026_abnormal_inner_ear0.66577227
140MP0008874_decreased_physiological_sensi0.66355400
141MP0001664_abnormal_digestion0.63780138
142MP0002089_abnormal_postnatal_growth/wei0.61898788
143MP0008872_abnormal_physiological_respon0.61877886
144MP0001943_abnormal_respiration0.61770866
145MP0005620_abnormal_muscle_contractility0.61069038
146MP0004036_abnormal_muscle_relaxation0.60915193
147MP0008775_abnormal_heart_ventricle0.60352314
148MP0005535_abnormal_body_temperature0.59282538
149MP0002653_abnormal_ependyma_morphology0.58757980
150MP0010769_abnormal_survival0.57478492
151MP0000013_abnormal_adipose_tissue0.57072270
152MP0002082_postnatal_lethality0.56518766
153MP0010770_preweaning_lethality0.56518766
154MP0005167_abnormal_blood-brain_barrier0.55255331

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.13265138
2Epileptic encephalopathy (HP:0200134)5.30624389
3Febrile seizures (HP:0002373)5.18020702
4Myokymia (HP:0002411)5.12266364
5Focal seizures (HP:0007359)4.58898706
6Progressive cerebellar ataxia (HP:0002073)4.31815644
7Visual hallucinations (HP:0002367)4.28258829
8Abnormality of nail color (HP:0100643)3.99628096
9Congenital stationary night blindness (HP:0007642)3.94230938
10Absence seizures (HP:0002121)3.71884042
11Action tremor (HP:0002345)3.70367589
12Atonic seizures (HP:0010819)3.64704781
13Broad-based gait (HP:0002136)3.43946569
14Central scotoma (HP:0000603)3.39802553
15Dialeptic seizures (HP:0011146)3.32298762
16Generalized tonic-clonic seizures (HP:0002069)3.26892490
17Hemiparesis (HP:0001269)3.13976262
18Hyperventilation (HP:0002883)3.12154526
19Fragile nails (HP:0001808)3.09009716
20Dysdiadochokinesis (HP:0002075)3.06873884
21Poor eye contact (HP:0000817)3.01083063
22Gaze-evoked nystagmus (HP:0000640)2.97017070
23Genetic anticipation (HP:0003743)2.96764166
24Supranuclear gaze palsy (HP:0000605)2.94115665
25Atrophic scars (HP:0001075)2.88407322
26Depression (HP:0000716)2.87028509
27High anterior hairline (HP:0009890)2.86107792
28Abnormal social behavior (HP:0012433)2.71934179
29Impaired social interactions (HP:0000735)2.71934179
30Split foot (HP:0001839)2.71878140
31Cutaneous finger syndactyly (HP:0010554)2.70747566
32Scanning speech (HP:0002168)2.69767769
33Anxiety (HP:0000739)2.68139252
34Drooling (HP:0002307)2.63371378
35Excessive salivation (HP:0003781)2.63371378
36Truncal ataxia (HP:0002078)2.62749101
37Pterygium (HP:0001059)2.62630131
38Exercise-induced muscle cramps (HP:0003710)2.61431128
39Mutism (HP:0002300)2.55682944
40Scotoma (HP:0000575)2.51834257
41Amblyopia (HP:0000646)2.49421576
42Progressive inability to walk (HP:0002505)2.49216012
43Urinary bladder sphincter dysfunction (HP:0002839)2.46639831
44Fetal akinesia sequence (HP:0001989)2.46253847
45Plantar hyperkeratosis (HP:0007556)2.45877163
46Hepatoblastoma (HP:0002884)2.44865044
47Impaired smooth pursuit (HP:0007772)2.44107018
48Calcaneovalgus deformity (HP:0001848)2.41671415
49Cutaneous syndactyly (HP:0012725)2.41369982
50Abnormality of binocular vision (HP:0011514)2.40987834
51Diplopia (HP:0000651)2.40987834
52Cortical dysplasia (HP:0002539)2.40251217
53Abnormality of macular pigmentation (HP:0008002)2.40233163
54Onycholysis (HP:0001806)2.40151338
55Dysmetria (HP:0001310)2.38411770
56Morphological abnormality of the middle ear (HP:0008609)2.36991710
57Absent speech (HP:0001344)2.34879857
58Coronal craniosynostosis (HP:0004440)2.34614115
59Aplasia involving bones of the upper limbs (HP:0009823)2.34416136
60Aplasia of the phalanges of the hand (HP:0009802)2.34416136
61Aplasia involving bones of the extremities (HP:0009825)2.34416136
62Ankle clonus (HP:0011448)2.29799220
63Abnormal eating behavior (HP:0100738)2.29623261
64Impaired vibration sensation in the lower limbs (HP:0002166)2.29309762
65Hemiplegia (HP:0002301)2.29128482
66Gait imbalance (HP:0002141)2.27892371
67Postural instability (HP:0002172)2.27034423
68Severe visual impairment (HP:0001141)2.25921666
69Turricephaly (HP:0000262)2.25564934
70Esophageal atresia (HP:0002032)2.25145549
71Milia (HP:0001056)2.24872332
72Partial duplication of thumb phalanx (HP:0009944)2.24826691
73Fatigable weakness (HP:0003473)2.22029744
74Abnormality of the neuromuscular junction (HP:0003398)2.22029744
75Labial hypoplasia (HP:0000066)2.21110564
76Prolonged QT interval (HP:0001657)2.20789890
77Myelomeningocele (HP:0002475)2.19223023
78Stereotypic behavior (HP:0000733)2.19056981
79Abnormality of the labia minora (HP:0012880)2.16694088
80Abnormality of ocular smooth pursuit (HP:0000617)2.15106278
81Protruding tongue (HP:0010808)2.12498731
82Deformed tarsal bones (HP:0008119)2.11350031
83Vaginal atresia (HP:0000148)2.10221453
84Epileptiform EEG discharges (HP:0011182)2.10110319
85Hypoplastic labia majora (HP:0000059)2.09989082
86Genital tract atresia (HP:0001827)2.09911291
87Abnormal rod and cone electroretinograms (HP:0008323)2.09367640
88Abnormal EKG (HP:0003115)2.09281786
89Renal dysplasia (HP:0000110)2.03586945
90EEG with generalized epileptiform discharges (HP:0011198)2.02820372
91Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.01815132
92Hypoventilation (HP:0002791)2.00888403
93Anophthalmia (HP:0000528)1.99533472
94Megalencephaly (HP:0001355)1.97890832
95Abnormality of permanent molar morphology (HP:0011071)1.97810946
96Abnormality of the dental root (HP:0006486)1.97810946
97Taurodontia (HP:0000679)1.97810946
98Abnormality of the labia majora (HP:0012881)1.97768100
99Septo-optic dysplasia (HP:0100842)1.97639264
100Abnormality of dentin (HP:0010299)1.95120811
101Blue irides (HP:0000635)1.94437031
102Ventricular fibrillation (HP:0001663)1.93802205
103Narrow nasal bridge (HP:0000446)1.93730142
104Hypoplastic female external genitalia (HP:0012815)1.92059827
105Inability to walk (HP:0002540)1.91413637
106Dysmetric saccades (HP:0000641)1.91300037
107Failure to thrive in infancy (HP:0001531)1.91182242
108Vitreoretinal degeneration (HP:0000655)1.90976854
109Cholecystitis (HP:0001082)1.90409167
110Abnormal gallbladder physiology (HP:0012438)1.90409167
111Status epilepticus (HP:0002133)1.90025304
112Congenital primary aphakia (HP:0007707)1.89287216
113Pointed chin (HP:0000307)1.88751555
114Torticollis (HP:0000473)1.88610228
115Nephrogenic diabetes insipidus (HP:0009806)1.88155331
116Palmoplantar hyperkeratosis (HP:0000972)1.87863471
117Retinal dysplasia (HP:0007973)1.87666681
118Annular pancreas (HP:0001734)1.87644589
119Medial flaring of the eyebrow (HP:0010747)1.87565400
120Nephronophthisis (HP:0000090)1.87230063
121Agitation (HP:0000713)1.86702628
122Spastic gait (HP:0002064)1.86339929
123Renal hypoplasia (HP:0000089)1.85466290
124Anencephaly (HP:0002323)1.84804430
125Hypsarrhythmia (HP:0002521)1.84211300
126Palmar hyperkeratosis (HP:0010765)1.83633779
127Partial duplication of the phalanx of hand (HP:0009999)1.83104447
128Urinary urgency (HP:0000012)1.82992048
129Midline defect of the nose (HP:0004122)1.81997371
130Focal dystonia (HP:0004373)1.80245239
131Decreased central vision (HP:0007663)1.80006567
132Optic nerve hypoplasia (HP:0000609)1.79807262
133Gastrointestinal atresia (HP:0002589)1.79618817
134Absent/shortened dynein arms (HP:0200106)1.79531104
135Dynein arm defect of respiratory motile cilia (HP:0012255)1.79531104
136Polyphagia (HP:0002591)1.79362126
137Stenosis of the external auditory canal (HP:0000402)1.79301078
138Abnormality of the lower motor neuron (HP:0002366)1.79139202
139Specific learning disability (HP:0001328)1.79031392
140Neonatal short-limb short stature (HP:0008921)1.78308351
141Abnormality of molar morphology (HP:0011070)1.78188383
142Abnormality of molar (HP:0011077)1.78188383
143Incomplete penetrance (HP:0003829)1.78031554
144Insomnia (HP:0100785)1.77828421
145Lissencephaly (HP:0001339)1.77669386
146Bradykinesia (HP:0002067)1.77621037
147Exotropia (HP:0000577)1.76354578
148Limb dystonia (HP:0002451)1.76156555
149Autism (HP:0000717)1.75460769
150Trigonocephaly (HP:0000243)1.74415554
151Abnormality of salivation (HP:0100755)1.73741852
152Widely spaced teeth (HP:0000687)1.71456809
153Abnormality of the corticospinal tract (HP:0002492)1.70934279
154Alopecia of scalp (HP:0002293)1.70634403
155Poor coordination (HP:0002370)1.69875023
156Inappropriate behavior (HP:0000719)1.69660345
157Bronchomalacia (HP:0002780)1.69437544
158Abnormality of the dental pulp (HP:0006479)1.69383744
159Psychosis (HP:0000709)1.69344855
160Intention tremor (HP:0002080)1.69302242
161Akinesia (HP:0002304)1.68344920
162Laryngomalacia (HP:0001601)1.68294443
163Lower limb muscle weakness (HP:0007340)1.67554520
164Pachygyria (HP:0001302)1.67352309
165Hypoplasia of the brainstem (HP:0002365)1.67021303
166Aplasia/Hypoplasia of the brainstem (HP:0007362)1.67021303
167Popliteal pterygium (HP:0009756)1.66076157
168Absent eyelashes (HP:0000561)1.66025099
169Absent septum pellucidum (HP:0001331)1.64658758
170Rib fusion (HP:0000902)1.63343494
171Omphalocele (HP:0001539)1.59587428
172Abnormality of the renal medulla (HP:0100957)1.58829775
173Abnormality of incisor morphology (HP:0011063)1.57299893
174Anterior segment dysgenesis (HP:0007700)1.56513303
175Recurrent corneal erosions (HP:0000495)1.56284836
176Maternal diabetes (HP:0009800)1.55706784
177Aqueductal stenosis (HP:0002410)1.55634219
178Cupped ear (HP:0000378)1.53277605
179Ridged nail (HP:0001807)1.51853534
180Alacrima (HP:0000522)1.49404209
181Preaxial foot polydactyly (HP:0001841)1.48655905
182Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.48062993
183Choanal stenosis (HP:0000452)1.47953277
184Abnormality of the antihelix (HP:0009738)1.47600103
185Sparse scalp hair (HP:0002209)1.47062619
186Pancreatic fibrosis (HP:0100732)1.47018961
187Thick nail (HP:0001805)1.46820579

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.23252793
2EPHA43.79362348
3MARK13.49993499
4MAP3K42.99720846
5MAP2K72.84001866
6MAP3K92.75336017
7MINK12.57941638
8CASK2.56068666
9PKN22.54760310
10EPHB22.53957860
11BCR2.26229187
12NTRK22.24496894
13DYRK22.22831511
14TNIK2.12273669
15PRKD32.08984402
16FGFR22.08150218
17FLT31.98302171
18DAPK21.93284002
19PAK61.88159055
20KSR11.76378473
21STK38L1.74274816
22LATS21.71594797
23LATS11.65699997
24NEK21.65084506
25MAP2K41.62791217
26MAPK131.61457981
27PRPF4B1.55231435
28SGK21.54364161
29SIK21.53271968
30CAMKK11.48712086
31PHKG21.45811515
32PHKG11.45811515
33WNK31.44096350
34SGK2231.43522907
35SGK4941.43522907
36STK381.42590596
37EPHA31.41446839
38KSR21.36759619
39MOS1.36616969
40CDK51.34533486
41TRIM281.34259678
42PLK21.33994179
43RIPK41.33577525
44SGK31.24476997
45GRK51.21228099
46FES1.21005326
47NME11.19766799
48OBSCN1.17375260
49PNCK1.16250397
50MAPK151.15292683
51PRKCG1.14637958
52CAMKK21.13719353
53CDK191.11760817
54DAPK11.07989582
55MAP3K131.07882914
56CAMK1G1.05344268
57CAMK11.04513950
58PRKCH1.00891024
59PINK11.00095459
60NTRK10.99201778
61MUSK0.98636970
62CAMK2A0.98010622
63MAP3K120.95898532
64YES10.93303650
65FGFR10.91828988
66SIK30.90842315
67DYRK1A0.89717947
68CSNK1G30.88999490
69MKNK10.88493717
70TGFBR10.87513941
71CSNK1A1L0.85760139
72ARAF0.85640509
73SGK10.84680592
74MAP3K100.81870343
75PTK2B0.80586818
76AKT30.79602336
77BRD40.78852447
78TNK20.78338796
79STK110.77389380
80RPS6KA40.76759442
81UHMK10.74320205
82CSNK1G10.73945010
83WNK10.72309367
84LMTK20.69757494
85ERBB30.68682092
86RET0.68653387
87TAF10.68084379
88MKNK20.67939917
89BMPR20.67142382
90CDK180.66907883
91PRKCE0.66696316
92CDK120.66390775
93CAMK2B0.65763538
94RAF10.64068613
95BMPR1B0.63733120
96MARK20.63069398
97CDK150.62634461
98CDK140.59877633
99PDGFRA0.58932424
100STK240.58904665
101DDR20.58719738
102TYRO30.58256832
103CAMK2D0.57322708
104CAMK40.56411701
105GRK70.55226701
106RPS6KA30.55161780
107CDK11A0.54664029
108BCKDK0.53736146
109EEF2K0.53635221
110CDC42BPA0.52396753
111WNK40.51752724
112MAP3K60.50922837
113MAPK70.50613112
114TAOK20.50119909
115RPS6KA20.49454895
116ALK0.48991299
117CSNK1G20.48415688
118RPS6KB10.48388799
119ROCK20.46055685
120PAK30.45906076
121DYRK1B0.45516754
122PKN10.45394902
123PRKCZ0.45330179
124MAPK120.45284962
125MAPK100.45211164
126INSRR0.44669608
127NEK10.44626632
128CDK30.44595180
129PRKACA0.42999377
130MET0.42689074
131MAP3K20.42071448
132CAMK2G0.41819285
133VRK10.41290024
134FYN0.40549566
135PDK10.40423826
136PRKG10.40266552
137CAMK1D0.39715300
138DYRK30.38569957
139ROCK10.38120806
140PRKD20.38080784
141NEK60.38044985
142PRKCB0.37440901
143TSSK60.36224602
144MAPK90.36029603
145STK30.35687913
146PRKAA10.35662884
147MARK30.35271356
148RPS6KA10.34915467
149MAPKAPK50.31853249
150CSNK1E0.31714734

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.15254002
2Synaptic vesicle cycle_Homo sapiens_hsa047212.98051628
3GABAergic synapse_Homo sapiens_hsa047272.90655646
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.80384496
5Circadian entrainment_Homo sapiens_hsa047132.75527781
6Morphine addiction_Homo sapiens_hsa050322.72418334
7Basal cell carcinoma_Homo sapiens_hsa052172.61134062
8Olfactory transduction_Homo sapiens_hsa047402.53960327
9Glutamatergic synapse_Homo sapiens_hsa047242.52241992
10Long-term potentiation_Homo sapiens_hsa047202.30486129
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.20913397
12Amphetamine addiction_Homo sapiens_hsa050312.16277296
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.10236325
14Salivary secretion_Homo sapiens_hsa049702.06716476
15Dopaminergic synapse_Homo sapiens_hsa047281.97286144
16Phototransduction_Homo sapiens_hsa047441.95095030
17Insulin secretion_Homo sapiens_hsa049111.90757939
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.90190542
19Ribosome_Homo sapiens_hsa030101.87116942
20Cholinergic synapse_Homo sapiens_hsa047251.86611195
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.86385293
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.84965503
23Renin secretion_Homo sapiens_hsa049241.84430008
24Taste transduction_Homo sapiens_hsa047421.83935511
25Serotonergic synapse_Homo sapiens_hsa047261.74985019
26Hippo signaling pathway_Homo sapiens_hsa043901.69326514
27Oxytocin signaling pathway_Homo sapiens_hsa049211.69000220
28Long-term depression_Homo sapiens_hsa047301.67415416
29Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.66901136
30Gastric acid secretion_Homo sapiens_hsa049711.65312616
31Calcium signaling pathway_Homo sapiens_hsa040201.62400024
32Steroid biosynthesis_Homo sapiens_hsa001001.61965080
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.57098719
34Fructose and mannose metabolism_Homo sapiens_hsa000511.55606925
35Cocaine addiction_Homo sapiens_hsa050301.50376680
36Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.42029818
37Butanoate metabolism_Homo sapiens_hsa006501.36646757
38ECM-receptor interaction_Homo sapiens_hsa045121.34128485
39cAMP signaling pathway_Homo sapiens_hsa040241.33556164
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31926556
41Nitrogen metabolism_Homo sapiens_hsa009101.29339946
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.28288151
43Parkinsons disease_Homo sapiens_hsa050121.28222283
44GnRH signaling pathway_Homo sapiens_hsa049121.26856481
45Gap junction_Homo sapiens_hsa045401.26318419
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.25479903
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24012870
48Biosynthesis of amino acids_Homo sapiens_hsa012301.18463888
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16638940
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16284638
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16103300
52Cardiac muscle contraction_Homo sapiens_hsa042601.15885678
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15834766
54Axon guidance_Homo sapiens_hsa043601.14938185
55Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13478699
56Adherens junction_Homo sapiens_hsa045201.08436542
57Dilated cardiomyopathy_Homo sapiens_hsa054141.07163780
58Type II diabetes mellitus_Homo sapiens_hsa049301.06794676
59Notch signaling pathway_Homo sapiens_hsa043301.06707317
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.06225678
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04859367
62ErbB signaling pathway_Homo sapiens_hsa040121.01918936
63Circadian rhythm_Homo sapiens_hsa047100.99671828
64Collecting duct acid secretion_Homo sapiens_hsa049660.99250771
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.96882763
66Oxidative phosphorylation_Homo sapiens_hsa001900.96781426
67Protein digestion and absorption_Homo sapiens_hsa049740.95256156
68Glioma_Homo sapiens_hsa052140.92728413
69Dorso-ventral axis formation_Homo sapiens_hsa043200.92376125
70Melanogenesis_Homo sapiens_hsa049160.89577749
71Estrogen signaling pathway_Homo sapiens_hsa049150.89394418
72Huntingtons disease_Homo sapiens_hsa050160.82713399
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81228467
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80641486
75Tight junction_Homo sapiens_hsa045300.80445133
76Basal transcription factors_Homo sapiens_hsa030220.78956969
77Propanoate metabolism_Homo sapiens_hsa006400.77475373
78HIF-1 signaling pathway_Homo sapiens_hsa040660.76126162
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75934236
80mRNA surveillance pathway_Homo sapiens_hsa030150.75758937
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75573314
82Protein export_Homo sapiens_hsa030600.75214758
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.75164708
84MicroRNAs in cancer_Homo sapiens_hsa052060.74958472
85* MAPK signaling pathway_Homo sapiens_hsa040100.74425736
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74396063
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73966788
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71883297
89Choline metabolism in cancer_Homo sapiens_hsa052310.71372891
90Pancreatic secretion_Homo sapiens_hsa049720.71332070
91Arginine and proline metabolism_Homo sapiens_hsa003300.67758122
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66980723
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66016670
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65752099
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65703348
96Renal cell carcinoma_Homo sapiens_hsa052110.65094731
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65069549
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63667223
99Oocyte meiosis_Homo sapiens_hsa041140.62590875
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61938213
101Inositol phosphate metabolism_Homo sapiens_hsa005620.61585415
102RNA degradation_Homo sapiens_hsa030180.60024520
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60004067
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.59896332
105* Ras signaling pathway_Homo sapiens_hsa040140.58607203
106Carbon metabolism_Homo sapiens_hsa012000.58195264
107* Pathways in cancer_Homo sapiens_hsa052000.57885486
108Thyroid hormone synthesis_Homo sapiens_hsa049180.57053164
109Vibrio cholerae infection_Homo sapiens_hsa051100.56391421
110Lysine degradation_Homo sapiens_hsa003100.55838683
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55103162
112Ether lipid metabolism_Homo sapiens_hsa005650.55071529
113Glucagon signaling pathway_Homo sapiens_hsa049220.54155255
114* Rap1 signaling pathway_Homo sapiens_hsa040150.52549557
115Linoleic acid metabolism_Homo sapiens_hsa005910.50810750
116Wnt signaling pathway_Homo sapiens_hsa043100.49451416
117Ovarian steroidogenesis_Homo sapiens_hsa049130.49419694
118AMPK signaling pathway_Homo sapiens_hsa041520.49321680
119mTOR signaling pathway_Homo sapiens_hsa041500.47074739
120Arginine biosynthesis_Homo sapiens_hsa002200.46753445
121Endometrial cancer_Homo sapiens_hsa052130.44134950
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43389579
123Alcoholism_Homo sapiens_hsa050340.42874916
124Non-small cell lung cancer_Homo sapiens_hsa052230.40522957
125Insulin signaling pathway_Homo sapiens_hsa049100.40515043
126SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39847791
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.38963197
128VEGF signaling pathway_Homo sapiens_hsa043700.38462590
129Type I diabetes mellitus_Homo sapiens_hsa049400.35894244
130Endocytosis_Homo sapiens_hsa041440.35578918
131Colorectal cancer_Homo sapiens_hsa052100.35536820
132Mineral absorption_Homo sapiens_hsa049780.35476422
133Chemokine signaling pathway_Homo sapiens_hsa040620.32806761
134Bile secretion_Homo sapiens_hsa049760.31047713
135Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30163517
136Hedgehog signaling pathway_Homo sapiens_hsa043400.30041506
137Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29596317
138Central carbon metabolism in cancer_Homo sapiens_hsa052300.29487864
139Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.27936452
140Alzheimers disease_Homo sapiens_hsa050100.25612980
141* Melanoma_Homo sapiens_hsa052180.24542549

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