FGF12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.84696031
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.81925624
3glutamate secretion (GO:0014047)5.71134017
4synaptic vesicle maturation (GO:0016188)5.52428353
5synaptic vesicle docking involved in exocytosis (GO:0016081)5.40449631
6regulation of synaptic vesicle exocytosis (GO:2000300)5.37408945
7neuronal action potential propagation (GO:0019227)5.25443969
8vocalization behavior (GO:0071625)5.24939653
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.07405736
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.02063564
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.89828464
12locomotory exploration behavior (GO:0035641)4.89192665
13regulation of synaptic vesicle transport (GO:1902803)4.71162197
14neuron cell-cell adhesion (GO:0007158)4.68361883
15protein localization to synapse (GO:0035418)4.68190401
16neurotransmitter secretion (GO:0007269)4.67539410
17regulation of glutamate receptor signaling pathway (GO:1900449)4.59828168
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.49828246
19gamma-aminobutyric acid transport (GO:0015812)4.19332411
20neurotransmitter-gated ion channel clustering (GO:0072578)4.15278390
21ionotropic glutamate receptor signaling pathway (GO:0035235)4.14464483
22proline transport (GO:0015824)4.09474513
23neuron-neuron synaptic transmission (GO:0007270)4.04577701
24synaptic transmission, glutamatergic (GO:0035249)4.01118762
25membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.00177111
26negative regulation of synaptic transmission, GABAergic (GO:0032229)3.99407761
27regulation of neuronal synaptic plasticity (GO:0048168)3.90565690
28regulation of long-term neuronal synaptic plasticity (GO:0048169)3.88645274
29exploration behavior (GO:0035640)3.87809903
30negative regulation of cytosolic calcium ion concentration (GO:0051481)3.86507663
31neurotransmitter transport (GO:0006836)3.75158073
32glutamate receptor signaling pathway (GO:0007215)3.74858747
33regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.72156835
34gamma-aminobutyric acid signaling pathway (GO:0007214)3.70846472
35activation of protein kinase A activity (GO:0034199)3.67097465
36presynaptic membrane assembly (GO:0097105)3.66740403
37cerebellar Purkinje cell differentiation (GO:0021702)3.66500253
38atrial cardiac muscle cell action potential (GO:0086014)3.66066817
39regulation of membrane repolarization (GO:0060306)3.64393557
40regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.53890447
41long-term synaptic potentiation (GO:0060291)3.53677128
42postsynaptic membrane organization (GO:0001941)3.53176974
43regulation of excitatory postsynaptic membrane potential (GO:0060079)3.53069134
44neuromuscular process controlling posture (GO:0050884)3.52277587
45regulation of synapse structural plasticity (GO:0051823)3.50481162
46negative regulation of dendrite morphogenesis (GO:0050774)3.50149673
47regulation of neurotransmitter secretion (GO:0046928)3.50067553
48positive regulation of membrane potential (GO:0045838)3.49063170
49presynaptic membrane organization (GO:0097090)3.46805258
50cellular potassium ion homeostasis (GO:0030007)3.45154086
51layer formation in cerebral cortex (GO:0021819)3.45143865
52membrane depolarization during action potential (GO:0086010)3.44296607
53regulation of neurotransmitter levels (GO:0001505)3.42388253
54regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.38709540
55regulation of synaptic plasticity (GO:0048167)3.38179973
56regulation of postsynaptic membrane potential (GO:0060078)3.37315003
57cardiac conduction (GO:0061337)3.37128894
58positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.36674326
59long-term memory (GO:0007616)3.34875509
60regulation of synaptic transmission, glutamatergic (GO:0051966)3.34029440
61negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.33898573
62positive regulation of action potential (GO:0045760)3.32935312
63positive regulation of synaptic transmission, GABAergic (GO:0032230)3.32354458
64synaptic vesicle endocytosis (GO:0048488)3.32033826
65regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.31785313
66positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.28142607
67regulation of neurotransmitter transport (GO:0051588)3.25380596
68positive regulation of synapse maturation (GO:0090129)3.24139643
69cell communication involved in cardiac conduction (GO:0086065)3.22962424
70regulation of cell communication by electrical coupling (GO:0010649)3.20056164
71positive regulation of neurotransmitter transport (GO:0051590)3.20018517
72neuron recognition (GO:0008038)3.19035257
73cell communication by electrical coupling (GO:0010644)3.16269695
74positive regulation of potassium ion transmembrane transport (GO:1901381)3.15290671
75regulation of heart rate by cardiac conduction (GO:0086091)3.14910311
76innervation (GO:0060384)3.13961600
77membrane depolarization (GO:0051899)3.13750063
78regulation of vesicle fusion (GO:0031338)3.13031966
79positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.10669821
80* synaptic transmission (GO:0007268)3.10136978
81startle response (GO:0001964)3.07811220
82transmission of nerve impulse (GO:0019226)3.07255359
83multicellular organismal signaling (GO:0035637)3.06795976
84calcium ion-dependent exocytosis (GO:0017156)3.06219999
85cell migration in hindbrain (GO:0021535)3.04857279
86cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.03276768
87response to histamine (GO:0034776)3.03225333
88positive regulation of synaptic transmission (GO:0050806)3.02472992
89transferrin transport (GO:0033572)3.02438121
90membrane hyperpolarization (GO:0060081)3.02285625
91regulation of synaptic transmission, GABAergic (GO:0032228)3.01476025
92energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.00684460
93ATP hydrolysis coupled proton transport (GO:0015991)3.00684460
94vesicle transport along microtubule (GO:0047496)2.99678919
95detection of calcium ion (GO:0005513)2.99395418
96auditory behavior (GO:0031223)2.98813625
97negative regulation of dendrite development (GO:2000171)2.98020387
98cerebellar granule cell differentiation (GO:0021707)2.97903614
99regulation of action potential (GO:0098900)2.97055089
100regulation of synaptic transmission (GO:0050804)2.96040577
101positive regulation of neurotransmitter secretion (GO:0001956)2.95184856
102synapse assembly (GO:0007416)2.95096542
103regulation of voltage-gated calcium channel activity (GO:1901385)2.94677426
104regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.94165503
105dendritic spine morphogenesis (GO:0060997)2.93829855
106glycine transport (GO:0015816)2.93463479
107sodium ion export (GO:0071436)2.92737658
108cellular ketone body metabolic process (GO:0046950)2.91693495
109righting reflex (GO:0060013)2.90187702
110serotonin metabolic process (GO:0042428)2.89265605
111neuromuscular process controlling balance (GO:0050885)2.89259288
112G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.87985572
113response to auditory stimulus (GO:0010996)2.87662834
114* action potential (GO:0001508)2.86660666
115establishment of synaptic vesicle localization (GO:0097480)2.85869189
116synaptic vesicle transport (GO:0048489)2.85869189
117behavioral response to cocaine (GO:0048148)2.85722674
118learning (GO:0007612)2.84570541
119inositol phosphate catabolic process (GO:0071545)2.84113661
120mechanosensory behavior (GO:0007638)2.82883812
121trivalent inorganic cation transport (GO:0072512)2.81371018
122ferric iron transport (GO:0015682)2.81371018
123C4-dicarboxylate transport (GO:0015740)2.80498925
124neuronal action potential (GO:0019228)2.78016808
125regulation of dendritic spine development (GO:0060998)2.73995499
126glycosphingolipid biosynthetic process (GO:0006688)2.71487917
127regulation of dendritic spine morphogenesis (GO:0061001)2.66402740
128urinary tract smooth muscle contraction (GO:0014848)2.65854794
129primary amino compound metabolic process (GO:1901160)2.63880569
130behavioral response to nicotine (GO:0035095)2.62892606
131positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.62485973
132regulation of neurotransmitter uptake (GO:0051580)2.61634029
133potassium ion homeostasis (GO:0055075)2.60427173
134* cardiac muscle cell action potential involved in contraction (GO:0086002)2.58874406
135* cardiac muscle cell action potential (GO:0086001)2.58592239
136positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.58198579
137nucleobase catabolic process (GO:0046113)2.56827148
138regulation of calcium ion-dependent exocytosis (GO:0017158)2.55973763
139ketone body metabolic process (GO:1902224)2.54086295
140water-soluble vitamin biosynthetic process (GO:0042364)2.52111142
141pyrimidine nucleobase catabolic process (GO:0006208)2.50180267
142aggressive behavior (GO:0002118)2.48904203
143insulin secretion (GO:0030073)2.47570353
144reflex (GO:0060004)2.46158986
145axonal fasciculation (GO:0007413)2.45815093
146positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.45298796
147regulation of sarcomere organization (GO:0060297)2.45224382
148positive regulation of sodium ion transmembrane transport (GO:1902307)2.44569412
149potassium ion import (GO:0010107)2.44165786

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.59932872
2* GBX2_23144817_ChIP-Seq_PC3_Human4.02381337
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.16239287
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.01996565
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.92590955
6REST_21632747_ChIP-Seq_MESCs_Mouse2.80963000
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.56844009
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.56844009
9* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55807344
10* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.53060679
11* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.48258622
12* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.44397571
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.44135439
14* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43395697
15RARB_27405468_Chip-Seq_BRAIN_Mouse2.41705605
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.39142074
17TAF15_26573619_Chip-Seq_HEK293_Human2.37112826
18* REST_18959480_ChIP-ChIP_MESCs_Mouse2.32304198
19DROSHA_22980978_ChIP-Seq_HELA_Human2.22421238
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.20903878
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.12697899
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.09099791
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.06879781
24* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.02417305
25* RNF2_27304074_Chip-Seq_ESCs_Mouse2.01546283
26CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01129174
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.99296531
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.98481970
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.96137001
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.93084838
31* SMAD4_21799915_ChIP-Seq_A2780_Human1.86758211
32* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79035606
33AR_21572438_ChIP-Seq_LNCaP_Human1.78304692
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.77750162
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.72695366
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70986030
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69815173
38* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69429694
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.65386286
40P300_19829295_ChIP-Seq_ESCs_Human1.62527612
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.59579506
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57780380
43ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.50359956
44EWS_26573619_Chip-Seq_HEK293_Human1.48902378
45NR3C1_23031785_ChIP-Seq_PC12_Mouse1.45838084
46* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44346971
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44209400
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.43351147
49* SOX2_21211035_ChIP-Seq_LN229_Gbm1.41540413
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41089733
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.38227717
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.38014194
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.37359412
54* AR_25329375_ChIP-Seq_VCAP_Human1.36092641
55EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35580663
56* STAT3_23295773_ChIP-Seq_U87_Human1.34586339
57* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34137664
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.34012875
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.33350094
60POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32804226
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.31217778
62* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29528043
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28690792
64BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28635612
65RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.26322391
66CBP_20019798_ChIP-Seq_JUKART_Human1.25854734
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25854734
68ZNF274_21170338_ChIP-Seq_K562_Hela1.24939078
69PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23718642
70VDR_22108803_ChIP-Seq_LS180_Human1.22671716
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.20869120
72EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20012241
73* RNF2_27304074_Chip-Seq_NSC_Mouse1.19397280
74IGF1R_20145208_ChIP-Seq_DFB_Human1.19342911
75* CBX2_27304074_Chip-Seq_ESCs_Mouse1.18440766
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18122607
77* FLI1_21867929_ChIP-Seq_TH2_Mouse1.18099919
78* TCF4_22108803_ChIP-Seq_LS180_Human1.17707482
79RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17206683
80* TCF4_23295773_ChIP-Seq_U87_Human1.17102140
81SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16976725
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.16834780
83P53_22387025_ChIP-Seq_ESCs_Mouse1.16483685
84* AR_19668381_ChIP-Seq_PC3_Human1.16205910
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16121297
86TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14770463
87AHR_22903824_ChIP-Seq_MCF-7_Human1.13036755
88P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11739622
89* RING1B_27294783_Chip-Seq_ESCs_Mouse1.11693647
90KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10363293
91KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10318299
92RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09476033
93EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08823109
94DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08713324
95NFE2_27457419_Chip-Seq_LIVER_Mouse1.07142284
96FUS_26573619_Chip-Seq_HEK293_Human1.07126872
97YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06583054
98PRDM14_20953172_ChIP-Seq_ESCs_Human1.04471635
99* EP300_21415370_ChIP-Seq_HL-1_Mouse1.04358781
100TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04275985
101UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04081872
102E2F1_18555785_Chip-Seq_ESCs_Mouse1.03890137
103CMYC_18555785_Chip-Seq_ESCs_Mouse1.03390000
104* RUNX2_22187159_ChIP-Seq_PCA_Human1.02873633
105MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02728785
106SOX2_19829295_ChIP-Seq_ESCs_Human1.02094172
107NANOG_19829295_ChIP-Seq_ESCs_Human1.02094172
108JUN_21703547_ChIP-Seq_K562_Human1.01036999
109ER_23166858_ChIP-Seq_MCF-7_Human1.00439371
110* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00372761
111TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00208815
112SMAD3_21741376_ChIP-Seq_ESCs_Human0.98909142
113WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97738945
114CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96989476
115RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96869178
116PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95702503
117CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93011167
118NANOG_18555785_Chip-Seq_ESCs_Mouse0.92743613
119TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91147662
120* SMAD4_21741376_ChIP-Seq_HESCs_Human0.89106486
121BCAT_22108803_ChIP-Seq_LS180_Human0.87990468
122RING1B_27294783_Chip-Seq_NPCs_Mouse0.87008784
123* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86871984
124TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84606105
125POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.84606105
126* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.83719437
127MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.83122221
128* SMAD4_21741376_ChIP-Seq_EPCs_Human0.82782310
129MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.82628237

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.69538934
2MP0003880_abnormal_central_pattern4.65990891
3* MP0003635_abnormal_synaptic_transmissio3.96022921
4MP0004270_analgesia3.91496962
5MP0001968_abnormal_touch/_nociception3.55168225
6MP0009046_muscle_twitch3.52196505
7MP0009745_abnormal_behavioral_response3.33822236
8MP0002064_seizures3.24589978
9* MP0002063_abnormal_learning/memory/cond3.12893212
10MP0002736_abnormal_nociception_after3.03964410
11MP0002735_abnormal_chemical_nociception2.99839549
12MP0002734_abnormal_mechanical_nocicepti2.94966693
13MP0002272_abnormal_nervous_system2.81414651
14* MP0002572_abnormal_emotion/affect_behav2.72461270
15MP0001486_abnormal_startle_reflex2.45580352
16MP0001501_abnormal_sleep_pattern2.38317237
17MP0003195_calcinosis2.37390544
18MP0002733_abnormal_thermal_nociception2.27851299
19MP0005423_abnormal_somatic_nervous2.25175658
20MP0001970_abnormal_pain_threshold2.20369754
21MP0002067_abnormal_sensory_capabilities2.19854003
22MP0009780_abnormal_chondrocyte_physiolo2.09259361
23MP0006276_abnormal_autonomic_nervous2.03718604
24MP0001984_abnormal_olfaction2.02574274
25MP0001440_abnormal_grooming_behavior2.01798597
26MP0002822_catalepsy1.97858512
27MP0004858_abnormal_nervous_system1.96245537
28MP0008569_lethality_at_weaning1.88722548
29MP0002184_abnormal_innervation1.88390631
30MP0005646_abnormal_pituitary_gland1.83231500
31MP0003879_abnormal_hair_cell1.75484935
32MP0004811_abnormal_neuron_physiology1.74015717
33MP0002909_abnormal_adrenal_gland1.72165861
34MP0002557_abnormal_social/conspecific_i1.71825534
35MP0003787_abnormal_imprinting1.70838467
36MP0006054_spinal_hemorrhage1.68583084
37MP0004924_abnormal_behavior1.68022424
38MP0005386_behavior/neurological_phenoty1.68022424
39MP0003329_amyloid_beta_deposits1.61815878
40MP0000778_abnormal_nervous_system1.58193454
41MP0000955_abnormal_spinal_cord1.54252024
42MP0004142_abnormal_muscle_tone1.47221390
43MP0003122_maternal_imprinting1.46413387
44MP0006072_abnormal_retinal_apoptosis1.40173123
45* MP0002066_abnormal_motor_capabilities/c1.40083688
46MP0002882_abnormal_neuron_morphology1.39563110
47MP0005645_abnormal_hypothalamus_physiol1.37420043
48MP0008775_abnormal_heart_ventricle1.35117433
49MP0001986_abnormal_taste_sensitivity1.32216774
50MP0003633_abnormal_nervous_system1.30618392
51MP0003121_genomic_imprinting1.30178128
52MP0002837_dystrophic_cardiac_calcinosis1.26977778
53MP0000013_abnormal_adipose_tissue1.25587519
54MP0001529_abnormal_vocalization1.22739340
55MP0002102_abnormal_ear_morphology1.19688145
56MP0001905_abnormal_dopamine_level1.18265775
57MP0005253_abnormal_eye_physiology1.17730567
58MP0004885_abnormal_endolymph1.16706188
59MP0004084_abnormal_cardiac_muscle1.15043016
60MP0001502_abnormal_circadian_rhythm1.11766139
61MP0000751_myopathy1.10120791
62MP0003631_nervous_system_phenotype1.08254720
63MP0002229_neurodegeneration1.08081341
64MP0002876_abnormal_thyroid_physiology1.08022212
65MP0010386_abnormal_urinary_bladder1.07068008
66MP0001188_hyperpigmentation1.05943381
67MP0003183_abnormal_peptide_metabolism0.98787412
68MP0003119_abnormal_digestive_system0.97226020
69MP0002152_abnormal_brain_morphology0.97012109
70MP0000516_abnormal_urinary_system0.94849085
71MP0005367_renal/urinary_system_phenotyp0.94849085
72MP0010234_abnormal_vibrissa_follicle0.94186702
73MP0008872_abnormal_physiological_respon0.93915047
74MP0001963_abnormal_hearing_physiology0.93146464
75MP0004130_abnormal_muscle_cell0.91005468
76MP0005551_abnormal_eye_electrophysiolog0.89338453
77MP0004742_abnormal_vestibular_system0.89334221
78MP0004043_abnormal_pH_regulation0.87828100
79MP0005499_abnormal_olfactory_system0.87342390
80MP0005394_taste/olfaction_phenotype0.87342390
81MP0002069_abnormal_eating/drinking_beha0.87298657
82MP0005187_abnormal_penis_morphology0.86770538
83MP0005379_endocrine/exocrine_gland_phen0.86710349
84MP0004085_abnormal_heartbeat0.86539430
85MP0008874_decreased_physiological_sensi0.85535966
86MP0004145_abnormal_muscle_electrophysio0.83972395
87MP0004215_abnormal_myocardial_fiber0.83851501
88MP0003634_abnormal_glial_cell0.82162182
89MP0004147_increased_porphyrin_level0.80850609
90MP0002972_abnormal_cardiac_muscle0.79451577
91MP0005620_abnormal_muscle_contractility0.79387202
92MP0005535_abnormal_body_temperature0.79061671
93MP0002752_abnormal_somatic_nervous0.77734382
94MP0003890_abnormal_embryonic-extraembry0.77331827
95MP0003646_muscle_fatigue0.75358147
96MP0002234_abnormal_pharynx_morphology0.74672515
97MP0004484_altered_response_of0.74037161
98MP0000427_abnormal_hair_cycle0.73560999
99MP0001944_abnormal_pancreas_morphology0.72614142
100MP0006292_abnormal_olfactory_placode0.71348086
101MP0001485_abnormal_pinna_reflex0.70386214
102MP0003632_abnormal_nervous_system0.69908432
103MP0001664_abnormal_digestion0.69847159
104MP0000569_abnormal_digit_pigmentation0.69829881
105MP0002693_abnormal_pancreas_physiology0.69528766
106MP0001177_atelectasis0.68306907
107MP0000604_amyloidosis0.68108272
108MP0003011_delayed_dark_adaptation0.67299335
109MP0000631_abnormal_neuroendocrine_gland0.66906495
110MP0004233_abnormal_muscle_weight0.66345115
111MP0000920_abnormal_myelination0.63085283
112MP0003283_abnormal_digestive_organ0.61698759
113MP0001299_abnormal_eye_distance/0.61309101
114MP0002638_abnormal_pupillary_reflex0.59508308
115MP0002090_abnormal_vision0.55925997
116MP0003690_abnormal_glial_cell0.55838646
117MP0001943_abnormal_respiration0.55253585
118MP0003137_abnormal_impulse_conducting0.54637660
119MP0008877_abnormal_DNA_methylation0.52237870
120MP0002751_abnormal_autonomic_nervous0.51338973
121MP0004036_abnormal_muscle_relaxation0.50871792
122MP0010770_preweaning_lethality0.50405890
123MP0002082_postnatal_lethality0.50405890
124MP0003956_abnormal_body_size0.50156357
125MP0010769_abnormal_survival0.50144622

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.23824159
2Myokymia (HP:0002411)6.39038992
3Atonic seizures (HP:0010819)6.07113490
4Focal seizures (HP:0007359)5.68824639
5Febrile seizures (HP:0002373)5.42593623
6Epileptic encephalopathy (HP:0200134)5.33891932
7Visual hallucinations (HP:0002367)4.88056926
8Absence seizures (HP:0002121)4.74972345
9Progressive cerebellar ataxia (HP:0002073)4.35464290
10Dialeptic seizures (HP:0011146)4.21109013
11Generalized tonic-clonic seizures (HP:0002069)4.05251309
12Action tremor (HP:0002345)3.78569265
13Hyperventilation (HP:0002883)3.69563141
14Pheochromocytoma (HP:0002666)3.65992223
15Neuroendocrine neoplasm (HP:0100634)3.33405133
16Syncope (HP:0001279)3.29459013
17Gaze-evoked nystagmus (HP:0000640)3.23623612
18Broad-based gait (HP:0002136)3.20204231
19Atrial fibrillation (HP:0005110)3.13971772
20Ankle clonus (HP:0011448)3.12899967
21Abnormal eating behavior (HP:0100738)3.12086392
22Impaired vibration sensation in the lower limbs (HP:0002166)3.07119491
23Methylmalonic acidemia (HP:0002912)3.05736818
24Poor eye contact (HP:0000817)3.05318442
25Truncal ataxia (HP:0002078)2.99207315
26Progressive inability to walk (HP:0002505)2.97631893
27Supranuclear gaze palsy (HP:0000605)2.97474414
28Dysdiadochokinesis (HP:0002075)2.95166007
29Primary atrial arrhythmia (HP:0001692)2.92707806
30Depression (HP:0000716)2.92006384
31Impaired social interactions (HP:0000735)2.87772379
32Abnormal social behavior (HP:0012433)2.87772379
33Bundle branch block (HP:0011710)2.87594432
34Insidious onset (HP:0003587)2.87475596
35Termporal pattern (HP:0011008)2.87475596
36Hypothermia (HP:0002045)2.86322991
37Amblyopia (HP:0000646)2.82134358
38Anxiety (HP:0000739)2.79082026
39Urinary bladder sphincter dysfunction (HP:0002839)2.78957653
40Supraventricular tachycardia (HP:0004755)2.78108420
41Progressive macrocephaly (HP:0004481)2.74115844
42Epileptiform EEG discharges (HP:0011182)2.70923802
43Supraventricular arrhythmia (HP:0005115)2.67815617
44Scanning speech (HP:0002168)2.66170945
45Prolonged QT interval (HP:0001657)2.65559127
46Acute necrotizing encephalopathy (HP:0006965)2.64862836
47Dysmetria (HP:0001310)2.64046030
48Sudden death (HP:0001699)2.61173385
49EEG with generalized epileptiform discharges (HP:0011198)2.56527786
50Urinary urgency (HP:0000012)2.52550349
51Fetal akinesia sequence (HP:0001989)2.50968387
52Inability to walk (HP:0002540)2.49651631
53Polyphagia (HP:0002591)2.45898744
54Hypsarrhythmia (HP:0002521)2.44923536
55Postural instability (HP:0002172)2.43088735
56Limb dystonia (HP:0002451)2.43024392
57Abnormality of binocular vision (HP:0011514)2.41788354
58Diplopia (HP:0000651)2.41788354
59Failure to thrive in infancy (HP:0001531)2.41242126
60Gait imbalance (HP:0002141)2.39703483
61Impaired smooth pursuit (HP:0007772)2.38959256
62Abnormality of vitamin B metabolism (HP:0004340)2.38476213
63Genetic anticipation (HP:0003743)2.37482365
64Spastic gait (HP:0002064)2.36162811
65Abnormal hair whorl (HP:0010721)2.34968684
66Drooling (HP:0002307)2.34588164
67Excessive salivation (HP:0003781)2.34588164
68Papilledema (HP:0001085)2.33841006
69Status epilepticus (HP:0002133)2.32165589
70Abnormal EKG (HP:0003115)2.31925518
71Torticollis (HP:0000473)2.31021673
72Bradykinesia (HP:0002067)2.28588960
73Mutism (HP:0002300)2.27608446
74Congenital sensorineural hearing impairment (HP:0008527)2.26546697
75Pancreatic cysts (HP:0001737)2.25225841
76Dysmetric saccades (HP:0000641)2.24445826
77Pancreatic fibrosis (HP:0100732)2.24250150
78Neoplasm of the peripheral nervous system (HP:0100007)2.22583858
79Methylmalonic aciduria (HP:0012120)2.22545404
80Abnormality of the corticospinal tract (HP:0002492)2.21092723
81Focal dystonia (HP:0004373)2.20620355
82Hemiparesis (HP:0001269)2.19319101
83Abnormality of the lower motor neuron (HP:0002366)2.16666373
84Abnormality of the labia minora (HP:0012880)2.16593074
85Impaired pain sensation (HP:0007328)2.16330960
86Abnormality of pain sensation (HP:0010832)2.16330960
87Resting tremor (HP:0002322)2.15765600
88Blue irides (HP:0000635)2.15498290
89Impaired vibratory sensation (HP:0002495)2.15345057
90Hemiplegia (HP:0002301)2.13387756
91Acute encephalopathy (HP:0006846)2.12865809
92Specific learning disability (HP:0001328)2.12445364
93Congenital stationary night blindness (HP:0007642)2.10153413
94Generalized myoclonic seizures (HP:0002123)2.10137510
95Poor suck (HP:0002033)2.10052010
96Nephronophthisis (HP:0000090)2.08121046
97Agitation (HP:0000713)2.07682862
98Palpitations (HP:0001962)2.06484562
99Absent speech (HP:0001344)2.06393614
100Ventricular fibrillation (HP:0001663)2.05911129
101Congenital primary aphakia (HP:0007707)2.05895194
102Abolished electroretinogram (ERG) (HP:0000550)2.05860634
103Abnormality of ocular smooth pursuit (HP:0000617)2.04675636
104Ketoacidosis (HP:0001993)2.04073057
105Left ventricular hypertrophy (HP:0001712)2.02415536
106True hermaphroditism (HP:0010459)2.02086546
107Abnormality of midbrain morphology (HP:0002418)1.99259455
108Molar tooth sign on MRI (HP:0002419)1.99259455
109Lower limb muscle weakness (HP:0007340)1.97848597
110Craniofacial dystonia (HP:0012179)1.96562537
111Vaginal atresia (HP:0000148)1.96411626
112Stereotypic behavior (HP:0000733)1.96177224
113Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.93838208
114Medial flaring of the eyebrow (HP:0010747)1.93454645
115Mitochondrial inheritance (HP:0001427)1.93289543
116Gait ataxia (HP:0002066)1.92407964
117Ulnar claw (HP:0001178)1.92214888
118Hypoventilation (HP:0002791)1.90849777
119Lissencephaly (HP:0001339)1.90093599
120Nephrogenic diabetes insipidus (HP:0009806)1.89921696
121Akinesia (HP:0002304)1.87944542
122Intention tremor (HP:0002080)1.87251343
123Type II lissencephaly (HP:0007260)1.86800438
124Postural tremor (HP:0002174)1.85760456
125Intestinal atresia (HP:0011100)1.85495384
126Psychosis (HP:0000709)1.85258752
127Neoplasm of the adrenal cortex (HP:0100641)1.85149445
128Heart block (HP:0012722)1.84047930
129Oligomenorrhea (HP:0000876)1.82985603
130Calf muscle hypertrophy (HP:0008981)1.82526625
131Congenital malformation of the right heart (HP:0011723)1.81154263
132Double outlet right ventricle (HP:0001719)1.81154263
133Hypomagnesemia (HP:0002917)1.79282514
134Incomplete penetrance (HP:0003829)1.79212171
135Renal cortical cysts (HP:0000803)1.78526996
136Abnormality of vitamin metabolism (HP:0100508)1.78485654
137Abnormality of the vitamin B12 metabolism (HP:0004341)1.77767043
138Spinal canal stenosis (HP:0003416)1.76960612
139Ketosis (HP:0001946)1.76042151
140Abnormality of the renal cortex (HP:0011035)1.75880049
141Increased CSF lactate (HP:0002490)1.73978762
142Pachygyria (HP:0001302)1.73368717
143Ventricular arrhythmia (HP:0004308)1.72998780
144Protruding tongue (HP:0010808)1.72916713
145Genital tract atresia (HP:0001827)1.71718798
146Attenuation of retinal blood vessels (HP:0007843)1.71589384
147Spastic tetraplegia (HP:0002510)1.71546559
148Neuronal loss in central nervous system (HP:0002529)1.70820076
149Muscular hypotonia of the trunk (HP:0008936)1.70132207
150Abnormal mitochondria in muscle tissue (HP:0008316)1.69770006
151Hyperthyroidism (HP:0000836)1.69554898
152Abnormality of the renal medulla (HP:0100957)1.69251347
153Hyperinsulinemic hypoglycemia (HP:0000825)1.67452827
154Pendular nystagmus (HP:0012043)1.67388674
155Hyperglycemia (HP:0003074)1.66111194
156Hypoglycemic coma (HP:0001325)1.64957244
157Cerebral edema (HP:0002181)1.64447329

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.48471091
2NTRK34.24644523
3CASK3.57344289
4MAP3K43.46667325
5MAP3K93.33406076
6MAP2K73.25012355
7EPHA43.01803155
8MAP3K122.92626780
9MINK12.79716806
10MARK12.68380837
11DAPK22.49414895
12MAP2K42.24124634
13CDK192.14683954
14MAP4K22.08474232
15NTRK11.90265109
16GRK11.89317022
17PAK61.80788081
18DAPK11.80319599
19PLK21.78642184
20KSR21.71867091
21NTRK21.71381192
22BMPR1B1.65144622
23GRK51.62917316
24CAMKK11.59452284
25FGFR21.49941801
26RIPK41.48651087
27PRPF4B1.43666348
28ERBB31.42960768
29PRKD31.41938468
30CAMKK21.41882061
31CDK51.41794341
32ACVR1B1.40880929
33NUAK11.38441873
34MAPK131.36088086
35ADRBK21.35945905
36CSNK1G11.35878560
37PRKCG1.31631587
38CSNK1G31.30117137
39ARAF1.28095995
40CCNB11.27722658
41KSR11.26499105
42AKT31.26311997
43MKNK21.26027438
44MAP3K21.25239192
45SGK4941.21409625
46SGK2231.21409625
47TRIM281.20407873
48OXSR11.20404896
49SGK21.14735922
50DYRK21.10642923
51PHKG11.10217323
52PHKG21.10217323
53BCKDK1.08231620
54TIE11.06498036
55CSNK1A1L1.05653854
56OBSCN1.04275866
57TNIK1.02348675
58STK380.99561694
59CAMK2A0.98456377
60LMTK20.97908604
61UHMK10.97693307
62PNCK0.95463581
63PDK30.94886006
64PDK40.94886006
65INSRR0.92643475
66SIK30.91501093
67STK390.88758929
68FES0.88570741
69SGK30.86795084
70CDK180.85902134
71CDK140.84573544
72LATS20.82169817
73PRKCH0.81699368
74RET0.80773744
75CAMK2B0.80033583
76CDK150.79375725
77NEK10.77583465
78TSSK60.77300240
79ZAK0.75978754
80SIK20.75168654
81MYLK0.74271378
82PLK30.71110095
83PINK10.70654627
84NME10.70013193
85CAMK10.69818290
86WNK10.68997787
87BMPR20.68582718
88PRKCE0.67970078
89CDK11A0.67145113
90STK110.66959096
91STK38L0.66325481
92MST40.64151908
93CSNK1G20.62944529
94PAK30.62727088
95PKN10.62683816
96LIMK10.61608194
97TNK20.60830414
98WNK30.59377323
99ROCK10.59253800
100PDK10.58601606
101SGK10.58511905
102DMPK0.58083939
103PRKACA0.57971056
104TAOK10.57737528
105PTK2B0.57376675
106WNK40.55928558
107CAMK2D0.55679317
108CAMK2G0.54735016
109PDPK10.54285528
110PRKG10.53837793
111BRAF0.53713429
112MAP3K10.53654272
113PRKAA10.53200298
114DYRK1A0.53022171
115FER0.51709174
116TYRO30.51301268
117BCR0.50997585
118MAP2K10.50910209
119RPS6KA20.49727563
120DAPK30.44481998
121MAP3K130.43717368
122CDC42BPA0.43493839
123CSNK1A10.42607859
124PRKCA0.42038018
125SCYL20.41747691
126RPS6KA30.41716224
127CSNK1D0.41248936
128PDK20.40572161
129PRKCZ0.39977122
130MARK20.37995884
131RAF10.37839413
132ALK0.37778936
133ROCK20.37115683
134PLK40.36472566
135PRKACB0.36266418
136ADRBK10.35919692
137PRKCI0.35481789
138BRSK10.35221634
139MAP2K60.34977735
140PIK3CA0.34477872
141CAMK40.34246427
142PRKCQ0.32629627
143PRKACG0.32286652
144CSNK1E0.30847823
145PRKCB0.29672363

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.00039015
2Nicotine addiction_Homo sapiens_hsa050333.72823203
3Olfactory transduction_Homo sapiens_hsa047402.88601383
4GABAergic synapse_Homo sapiens_hsa047272.74657443
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.70400617
6Circadian entrainment_Homo sapiens_hsa047132.57511743
7Collecting duct acid secretion_Homo sapiens_hsa049662.51587948
8Morphine addiction_Homo sapiens_hsa050322.49415339
9Long-term potentiation_Homo sapiens_hsa047202.47176560
10Glutamatergic synapse_Homo sapiens_hsa047242.35504132
11Amphetamine addiction_Homo sapiens_hsa050312.24402285
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.19276027
13Dopaminergic synapse_Homo sapiens_hsa047282.14037760
14Insulin secretion_Homo sapiens_hsa049112.13469880
15Maturity onset diabetes of the young_Homo sapiens_hsa049502.10927286
16Taste transduction_Homo sapiens_hsa047422.04239541
17Salivary secretion_Homo sapiens_hsa049702.01466001
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.78807868
19Cholinergic synapse_Homo sapiens_hsa047251.74682958
20Gastric acid secretion_Homo sapiens_hsa049711.70598600
21Vibrio cholerae infection_Homo sapiens_hsa051101.67559878
22Serotonergic synapse_Homo sapiens_hsa047261.65807163
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.60511945
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.57684040
25Long-term depression_Homo sapiens_hsa047301.54751213
26Renin secretion_Homo sapiens_hsa049241.53334130
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52057006
28Calcium signaling pathway_Homo sapiens_hsa040201.42916925
29Protein export_Homo sapiens_hsa030601.42759457
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41217761
31Oxytocin signaling pathway_Homo sapiens_hsa049211.41101637
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.35692788
33Cocaine addiction_Homo sapiens_hsa050301.34969624
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26457885
35Propanoate metabolism_Homo sapiens_hsa006401.25711254
36GnRH signaling pathway_Homo sapiens_hsa049121.23241281
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22929843
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21207270
39Gap junction_Homo sapiens_hsa045401.21167129
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.20317859
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.19655254
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.18178841
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.14209840
44Type II diabetes mellitus_Homo sapiens_hsa049301.10584871
45cAMP signaling pathway_Homo sapiens_hsa040241.10315499
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08298900
47Oxidative phosphorylation_Homo sapiens_hsa001901.05880139
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03518823
49Estrogen signaling pathway_Homo sapiens_hsa049151.02669880
50Regulation of autophagy_Homo sapiens_hsa041401.02629715
51Vitamin B6 metabolism_Homo sapiens_hsa007501.02459351
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01749144
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00994736
54Cardiac muscle contraction_Homo sapiens_hsa042601.00754186
55Phototransduction_Homo sapiens_hsa047440.94734469
56ErbB signaling pathway_Homo sapiens_hsa040120.92437575
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91987136
58Glioma_Homo sapiens_hsa052140.90133088
59Tryptophan metabolism_Homo sapiens_hsa003800.86103246
60Melanogenesis_Homo sapiens_hsa049160.85094067
61Axon guidance_Homo sapiens_hsa043600.84791095
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84225824
63Ether lipid metabolism_Homo sapiens_hsa005650.83598017
64Fatty acid elongation_Homo sapiens_hsa000620.82151242
65Alzheimers disease_Homo sapiens_hsa050100.81509696
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.81169314
67Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.79720176
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77214447
69beta-Alanine metabolism_Homo sapiens_hsa004100.75689058
70Oocyte meiosis_Homo sapiens_hsa041140.75597849
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75304186
72Thyroid hormone synthesis_Homo sapiens_hsa049180.74619073
73Pancreatic secretion_Homo sapiens_hsa049720.73913042
74Sulfur metabolism_Homo sapiens_hsa009200.73834254
75Dorso-ventral axis formation_Homo sapiens_hsa043200.72486828
76Parkinsons disease_Homo sapiens_hsa050120.72225071
77Linoleic acid metabolism_Homo sapiens_hsa005910.72054382
78Type I diabetes mellitus_Homo sapiens_hsa049400.69625458
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68074219
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68036122
81Fatty acid metabolism_Homo sapiens_hsa012120.67874403
82Peroxisome_Homo sapiens_hsa041460.67711640
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67679100
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67003742
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66116659
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65660468
87Selenocompound metabolism_Homo sapiens_hsa004500.63876769
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61997949
89Glucagon signaling pathway_Homo sapiens_hsa049220.61416315
90Folate biosynthesis_Homo sapiens_hsa007900.58488207
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58377983
92Mineral absorption_Homo sapiens_hsa049780.57403068
93Rheumatoid arthritis_Homo sapiens_hsa053230.56547470
94* MAPK signaling pathway_Homo sapiens_hsa040100.55658201
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54982076
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54271193
97Dilated cardiomyopathy_Homo sapiens_hsa054140.53546555
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.52532946
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.52114270
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52002783
101Primary bile acid biosynthesis_Homo sapiens_hsa001200.51689825
102Steroid biosynthesis_Homo sapiens_hsa001000.50739453
103Inositol phosphate metabolism_Homo sapiens_hsa005620.48882253
104Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48644895
105ABC transporters_Homo sapiens_hsa020100.47807837
106Choline metabolism in cancer_Homo sapiens_hsa052310.44632663
107* Ras signaling pathway_Homo sapiens_hsa040140.44567372
108Phagosome_Homo sapiens_hsa041450.44255468
109Tight junction_Homo sapiens_hsa045300.43308934
110Insulin signaling pathway_Homo sapiens_hsa049100.43050169
111Huntingtons disease_Homo sapiens_hsa050160.42899492
1122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42845419
113Circadian rhythm_Homo sapiens_hsa047100.42013489
114Alcoholism_Homo sapiens_hsa050340.41993549
115Basal transcription factors_Homo sapiens_hsa030220.41955655
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41392718
117Pyruvate metabolism_Homo sapiens_hsa006200.40877501
118Fatty acid degradation_Homo sapiens_hsa000710.39465594
119Bile secretion_Homo sapiens_hsa049760.39239427
120Endocytosis_Homo sapiens_hsa041440.39000304
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38326824
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35042404
123Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34550526
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34356544
125Endometrial cancer_Homo sapiens_hsa052130.34282274
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.34082370
127Butanoate metabolism_Homo sapiens_hsa006500.33423568
128Prion diseases_Homo sapiens_hsa050200.33103739
129mTOR signaling pathway_Homo sapiens_hsa041500.31472032
130* Rap1 signaling pathway_Homo sapiens_hsa040150.31099431
131VEGF signaling pathway_Homo sapiens_hsa043700.30573904
132Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30441901
133Nitrogen metabolism_Homo sapiens_hsa009100.27527624
134Ovarian steroidogenesis_Homo sapiens_hsa049130.26149349
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25946922
136Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.24298486
137Renal cell carcinoma_Homo sapiens_hsa052110.23404268

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