FGF14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. A mutation in this gene is associated with autosomal dominant cerebral ataxia. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.87018084
2synaptic vesicle docking involved in exocytosis (GO:0016081)5.80898665
3vocalization behavior (GO:0071625)5.78629168
4presynaptic membrane assembly (GO:0097105)5.70280384
5neurotransmitter-gated ion channel clustering (GO:0072578)5.50797108
6presynaptic membrane organization (GO:0097090)5.50278829
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.49087501
8regulation of short-term neuronal synaptic plasticity (GO:0048172)5.46249513
9neuron cell-cell adhesion (GO:0007158)5.41835050
10synaptic vesicle exocytosis (GO:0016079)5.34115347
11regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.25090089
12glutamate secretion (GO:0014047)5.17364550
13regulation of glutamate receptor signaling pathway (GO:1900449)5.14172025
14protein localization to synapse (GO:0035418)5.04285903
15regulation of synaptic vesicle exocytosis (GO:2000300)4.94672405
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.80466440
17cerebellar granule cell differentiation (GO:0021707)4.78829338
18neuron-neuron synaptic transmission (GO:0007270)4.71520393
19glutamate receptor signaling pathway (GO:0007215)4.66998648
20synaptic transmission, glutamatergic (GO:0035249)4.66479114
21negative regulation of synaptic transmission, GABAergic (GO:0032229)4.65510804
22postsynaptic membrane organization (GO:0001941)4.59108142
23neuronal action potential propagation (GO:0019227)4.58458502
24neurotransmitter secretion (GO:0007269)4.44619157
25gamma-aminobutyric acid signaling pathway (GO:0007214)4.42987504
26locomotory exploration behavior (GO:0035641)4.40181918
27regulation of synaptic vesicle transport (GO:1902803)4.27933976
28axonemal dynein complex assembly (GO:0070286)4.26238333
29G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.23693121
30response to histamine (GO:0034776)4.20758975
31positive regulation of synapse maturation (GO:0090129)4.19886128
32cilium or flagellum-dependent cell motility (GO:0001539)4.17458521
33regulation of excitatory postsynaptic membrane potential (GO:0060079)4.16339327
34cilium movement (GO:0003341)4.14491505
35positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.11421289
36long-term synaptic potentiation (GO:0060291)4.09126685
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.07015276
38regulation of synaptic transmission, glutamatergic (GO:0051966)4.00097060
39synaptic vesicle maturation (GO:0016188)3.99770879
40membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.98055097
41regulation of postsynaptic membrane potential (GO:0060078)3.96127287
42positive regulation of neurotransmitter secretion (GO:0001956)3.80556564
43regulation of long-term neuronal synaptic plasticity (GO:0048169)3.79994250
44epithelial cilium movement (GO:0003351)3.77193096
45mechanosensory behavior (GO:0007638)3.75251435
46gamma-aminobutyric acid transport (GO:0015812)3.75105013
47positive regulation of membrane potential (GO:0045838)3.74622088
48negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.74476834
49epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.67029355
50exploration behavior (GO:0035640)3.65321652
51startle response (GO:0001964)3.64845754
52regulation of neuronal synaptic plasticity (GO:0048168)3.64019569
53regulation of glutamate secretion (GO:0014048)3.60775062
54cerebellar Purkinje cell differentiation (GO:0021702)3.60696698
55positive regulation of synapse assembly (GO:0051965)3.60652044
56regulation of neurotransmitter secretion (GO:0046928)3.58340227
57dendritic spine morphogenesis (GO:0060997)3.58272162
58neuron recognition (GO:0008038)3.57243394
59regulation of synapse maturation (GO:0090128)3.57218486
60neurotransmitter transport (GO:0006836)3.55989321
61positive regulation of neurotransmitter transport (GO:0051590)3.55324766
62positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.54844105
63cellular potassium ion homeostasis (GO:0030007)3.52902095
64regulation of synaptic plasticity (GO:0048167)3.51547830
65retinal cone cell development (GO:0046549)3.48066862
66behavioral response to cocaine (GO:0048148)3.48061395
67auditory behavior (GO:0031223)3.46482253
68long-term memory (GO:0007616)3.43186956
69regulation of synapse structural plasticity (GO:0051823)3.40273589
70membrane depolarization (GO:0051899)3.31576665
71negative regulation of dendrite morphogenesis (GO:0050774)3.29659709
72regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.29442568
73transferrin transport (GO:0033572)3.28850507
74regulation of neurotransmitter transport (GO:0051588)3.28593599
75axonal fasciculation (GO:0007413)3.27668223
76regulation of neurotransmitter levels (GO:0001505)3.26907356
77positive regulation of synaptic transmission (GO:0050806)3.25380056
78protein localization to cilium (GO:0061512)3.25272149
79proline transport (GO:0015824)3.24997612
80behavioral defense response (GO:0002209)3.24920256
81behavioral fear response (GO:0001662)3.24920256
82membrane hyperpolarization (GO:0060081)3.24034507
83energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.20838601
84ATP hydrolysis coupled proton transport (GO:0015991)3.20838601
85synapse assembly (GO:0007416)3.16444096
86detection of calcium ion (GO:0005513)3.16084226
87urinary tract smooth muscle contraction (GO:0014848)3.15477768
88negative regulation of dendrite development (GO:2000171)3.15294084
89axoneme assembly (GO:0035082)3.14824207
90fear response (GO:0042596)3.13787088
91synaptic vesicle endocytosis (GO:0048488)3.13333355
92serotonin metabolic process (GO:0042428)3.12588412
93* synaptic transmission (GO:0007268)3.09650814
94regulation of vesicle fusion (GO:0031338)3.09475982
95positive regulation of synaptic transmission, GABAergic (GO:0032230)3.09161129
96transmission of nerve impulse (GO:0019226)3.08756692
97regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.08670388
98striatum development (GO:0021756)3.07865541
99trivalent inorganic cation transport (GO:0072512)3.06048917
100ferric iron transport (GO:0015682)3.06048917
101regulation of synaptic transmission, GABAergic (GO:0032228)3.06001844
102sodium ion export (GO:0071436)3.04673292
103regulation of synaptic transmission (GO:0050804)3.04427205
104learning (GO:0007612)3.02833469
105membrane depolarization during action potential (GO:0086010)3.02247705
106regulation of synapse assembly (GO:0051963)3.01455480
107regulation of female receptivity (GO:0045924)3.01432857
108cell differentiation in hindbrain (GO:0021533)3.01364760
109response to auditory stimulus (GO:0010996)2.98251670
110female mating behavior (GO:0060180)2.97755734
111cellular sodium ion homeostasis (GO:0006883)2.96841259
112negative regulation of cytosolic calcium ion concentration (GO:0051481)2.96489355
113activation of protein kinase A activity (GO:0034199)2.96465871
114regulation of voltage-gated calcium channel activity (GO:1901385)2.96149232
115positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.95633651
116regulation of dendritic spine morphogenesis (GO:0061001)2.94371133
117cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.84421207
118regulation of calcium ion-dependent exocytosis (GO:0017158)2.82917428
119innervation (GO:0060384)2.80464732
120potassium ion homeostasis (GO:0055075)2.76306067
121glycosphingolipid biosynthetic process (GO:0006688)2.73107860
122regulation of dendritic spine development (GO:0060998)2.72562622
123righting reflex (GO:0060013)2.70440108
124nucleobase catabolic process (GO:0046113)2.68919785
125positive regulation of vesicle fusion (GO:0031340)2.67898793
126primary amino compound metabolic process (GO:1901160)2.66778344
127L-amino acid import (GO:0043092)2.66568413
128neuronal action potential (GO:0019228)2.63529042
129adult walking behavior (GO:0007628)2.63455185
130positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.61222035
131pyrimidine nucleobase catabolic process (GO:0006208)2.58927715
132dendrite morphogenesis (GO:0048813)2.58923990
133potassium ion import (GO:0010107)2.58802644
134positive regulation of dendritic spine development (GO:0060999)2.58789070
135brain morphogenesis (GO:0048854)2.58626415
136calcium ion-dependent exocytosis (GO:0017156)2.58468762
137regulation of cilium movement (GO:0003352)2.56340487
138negative regulation of hormone biosynthetic process (GO:0032353)2.55692366

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.54666786
2GBX2_23144817_ChIP-Seq_PC3_Human4.69665023
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.08294496
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.01312915
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.87612226
6TAF15_26573619_Chip-Seq_HEK293_Human2.70621920
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.66751529
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58299210
9* REST_21632747_ChIP-Seq_MESCs_Mouse2.54419405
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.47665789
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.47545402
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.44768452
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.44768452
14* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.39311072
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.38785937
16* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.37376134
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.30212416
18* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23575849
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.23219840
20* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.21972468
21RARB_27405468_Chip-Seq_BRAIN_Mouse2.16881872
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.11327664
23CTBP1_25329375_ChIP-Seq_LNCAP_Human2.09572685
24* REST_18959480_ChIP-ChIP_MESCs_Mouse2.06167678
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.04130223
26SMAD4_21799915_ChIP-Seq_A2780_Human1.99456352
27RNF2_27304074_Chip-Seq_ESCs_Mouse1.97715664
28DROSHA_22980978_ChIP-Seq_HELA_Human1.96413885
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.94481501
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.91965314
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.91514915
32* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.90481759
33* P300_19829295_ChIP-Seq_ESCs_Human1.90172833
34AR_21572438_ChIP-Seq_LNCaP_Human1.86374117
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84791924
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83700578
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.79436352
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.78145251
39* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.77061573
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.74005312
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.66548986
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.65058699
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64900481
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.63719507
45FUS_26573619_Chip-Seq_HEK293_Human1.62592389
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.62265932
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.59829331
48* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50866848
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48453584
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47309891
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46582891
52* AR_25329375_ChIP-Seq_VCAP_Human1.45877025
53RNF2_27304074_Chip-Seq_NSC_Mouse1.44112829
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43182607
55* SOX2_21211035_ChIP-Seq_LN229_Gbm1.41509849
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40578527
57MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.40381522
58* STAT3_23295773_ChIP-Seq_U87_Human1.35769250
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35264521
60VDR_22108803_ChIP-Seq_LS180_Human1.32250200
61* TCF4_23295773_ChIP-Seq_U87_Human1.30785660
62* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.29103172
63* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26644306
64ER_23166858_ChIP-Seq_MCF-7_Human1.26011054
65ARNT_22903824_ChIP-Seq_MCF-7_Human1.24517780
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24428057
67* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19628249
68IGF1R_20145208_ChIP-Seq_DFB_Human1.17853873
69ZNF274_21170338_ChIP-Seq_K562_Hela1.17686434
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17167801
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.16570951
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15381489
73AHR_22903824_ChIP-Seq_MCF-7_Human1.14119350
74* RUNX2_22187159_ChIP-Seq_PCA_Human1.12955865
75CBP_20019798_ChIP-Seq_JUKART_Human1.12803772
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12803772
77* AR_19668381_ChIP-Seq_PC3_Human1.12445277
78P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12008189
79TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11418874
80CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11035697
81PRDM14_20953172_ChIP-Seq_ESCs_Human1.10947823
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10079728
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10079728
84ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10065799
85ERG_21242973_ChIP-ChIP_JURKAT_Human1.09428462
86PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09184865
87TP53_18474530_ChIP-ChIP_U2OS_Human1.08043034
88YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07642313
89MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07524591
90EP300_21415370_ChIP-Seq_HL-1_Mouse1.07412810
91WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07228833
92TP53_16413492_ChIP-PET_HCT116_Human1.06441703
93LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06193502
94JUN_21703547_ChIP-Seq_K562_Human1.04587334
95* SOX9_26525672_Chip-Seq_HEART_Mouse1.02678372
96PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02188144
97* TAL1_26923725_Chip-Seq_HPCs_Mouse1.01628079
98RING1B_27294783_Chip-Seq_ESCs_Mouse1.01290906
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01230626
100E2F1_18555785_Chip-Seq_ESCs_Mouse1.01006933
101TCF4_22108803_ChIP-Seq_LS180_Human1.00808384
102FLI1_27457419_Chip-Seq_LIVER_Mouse0.99395091
103MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98769108
104KDM2B_26808549_Chip-Seq_REH_Human0.98162399
105EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96907393
106MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96441730
107* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96338765
108BCAT_22108803_ChIP-Seq_LS180_Human0.96175430
109NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95383246
110EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94962811
111P53_22387025_ChIP-Seq_ESCs_Mouse0.94809545
112EWS_26573619_Chip-Seq_HEK293_Human0.94164964

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.38083327
2MP0003880_abnormal_central_pattern5.21896122
3* MP0003635_abnormal_synaptic_transmissio4.05691243
4* MP0009745_abnormal_behavioral_response3.62833043
5MP0009046_muscle_twitch3.54755362
6MP0002063_abnormal_learning/memory/cond3.36516094
7MP0004270_analgesia3.35266591
8MP0001968_abnormal_touch/_nociception3.34594844
9* MP0002064_seizures3.33707345
10MP0002572_abnormal_emotion/affect_behav3.05183102
11MP0002822_catalepsy2.85911621
12MP0002736_abnormal_nociception_after2.81402117
13MP0002272_abnormal_nervous_system2.74771322
14MP0002734_abnormal_mechanical_nocicepti2.53708625
15MP0001486_abnormal_startle_reflex2.52457091
16MP0001501_abnormal_sleep_pattern2.34238375
17MP0002735_abnormal_chemical_nociception2.30163050
18MP0001440_abnormal_grooming_behavior2.21292471
19* MP0002067_abnormal_sensory_capabilities2.21169262
20MP0003787_abnormal_imprinting2.12083695
21MP0003879_abnormal_hair_cell2.10653209
22MP0009780_abnormal_chondrocyte_physiolo2.09610480
23MP0005646_abnormal_pituitary_gland2.05693916
24MP0005423_abnormal_somatic_nervous2.04444240
25MP0001188_hyperpigmentation2.02516779
26MP0002733_abnormal_thermal_nociception1.90883438
27MP0008569_lethality_at_weaning1.88355108
28MP0001970_abnormal_pain_threshold1.87248894
29MP0004924_abnormal_behavior1.84697697
30MP0005386_behavior/neurological_phenoty1.84697697
31MP0002184_abnormal_innervation1.84643685
32MP0002557_abnormal_social/conspecific_i1.83946956
33MP0000778_abnormal_nervous_system1.79738684
34MP0001984_abnormal_olfaction1.74245053
35MP0001529_abnormal_vocalization1.73987795
36MP0003122_maternal_imprinting1.72277068
37MP0006276_abnormal_autonomic_nervous1.60120953
38MP0004811_abnormal_neuron_physiology1.51899814
39MP0004142_abnormal_muscle_tone1.40730049
40MP0001905_abnormal_dopamine_level1.38230331
41* MP0002066_abnormal_motor_capabilities/c1.36894040
42MP0005171_absent_coat_pigmentation1.36132851
43MP0002876_abnormal_thyroid_physiology1.34645697
44MP0002837_dystrophic_cardiac_calcinosis1.33922950
45MP0002638_abnormal_pupillary_reflex1.32027168
46MP0000955_abnormal_spinal_cord1.29310239
47MP0002882_abnormal_neuron_morphology1.28883568
48MP0005645_abnormal_hypothalamus_physiol1.28073226
49MP0001986_abnormal_taste_sensitivity1.27728166
50MP0002909_abnormal_adrenal_gland1.24022144
51MP0001502_abnormal_circadian_rhythm1.23070435
52MP0003329_amyloid_beta_deposits1.20634916
53MP0008789_abnormal_olfactory_epithelium1.19053073
54MP0003283_abnormal_digestive_organ1.12779709
55* MP0003633_abnormal_nervous_system1.11266890
56MP0006072_abnormal_retinal_apoptosis1.09454180
57MP0004742_abnormal_vestibular_system1.07312375
58MP0004858_abnormal_nervous_system1.03462548
59MP0002152_abnormal_brain_morphology1.03264896
60MP0000751_myopathy1.02753722
61MP0005623_abnormal_meninges_morphology1.02110708
62MP0004145_abnormal_muscle_electrophysio0.98501175
63MP0002160_abnormal_reproductive_system0.98123313
64* MP0003631_nervous_system_phenotype0.98109174
65MP0008872_abnormal_physiological_respon0.98096473
66MP0001299_abnormal_eye_distance/0.97851115
67MP0004133_heterotaxia0.97567066
68MP0001963_abnormal_hearing_physiology0.96873419
69MP0002102_abnormal_ear_morphology0.96480016
70MP0000013_abnormal_adipose_tissue0.95544188
71MP0010386_abnormal_urinary_bladder0.94696676
72MP0005551_abnormal_eye_electrophysiolog0.93961699
73MP0005253_abnormal_eye_physiology0.93924958
74MP0008874_decreased_physiological_sensi0.93392023
75MP0002069_abnormal_eating/drinking_beha0.92567587
76MP0004885_abnormal_endolymph0.92421492
77MP0005499_abnormal_olfactory_system0.91653811
78MP0005394_taste/olfaction_phenotype0.91653811
79MP0004085_abnormal_heartbeat0.91119466
80MP0001944_abnormal_pancreas_morphology0.88393655
81MP0000427_abnormal_hair_cycle0.87750269
82MP0008875_abnormal_xenobiotic_pharmacok0.85640884
83MP0004215_abnormal_myocardial_fiber0.84953758
84MP0003183_abnormal_peptide_metabolism0.84923902
85MP0002229_neurodegeneration0.83677407
86MP0000631_abnormal_neuroendocrine_gland0.83570970
87MP0004484_altered_response_of0.80431858
88MP0004147_increased_porphyrin_level0.80299650
89MP0008877_abnormal_DNA_methylation0.79235297
90MP0005187_abnormal_penis_morphology0.78420832
91MP0004043_abnormal_pH_regulation0.76980065
92MP0003690_abnormal_glial_cell0.76946779
93MP0003121_genomic_imprinting0.76411363
94MP0001177_atelectasis0.74085852
95MP0002752_abnormal_somatic_nervous0.72452307
96MP0001664_abnormal_digestion0.72337069
97MP0000920_abnormal_myelination0.70825248
98MP0010234_abnormal_vibrissa_follicle0.70461688
99MP0001485_abnormal_pinna_reflex0.69205171
100MP0005535_abnormal_body_temperature0.68458601
101MP0003632_abnormal_nervous_system0.68106924
102MP0000026_abnormal_inner_ear0.66637029
103MP0002090_abnormal_vision0.66202271
104MP0001943_abnormal_respiration0.65252402
105MP0003195_calcinosis0.63342650
106MP0002928_abnormal_bile_duct0.62969443
107MP0000569_abnormal_digit_pigmentation0.60992225
108MP0005409_darkened_coat_color0.60631460
109MP0002653_abnormal_ependyma_morphology0.59206490
110MP0001765_abnormal_ion_homeostasis0.59194127
111MP0003718_maternal_effect0.59116809
112MP0002082_postnatal_lethality0.58302115
113MP0010770_preweaning_lethality0.58302115
114MP0006292_abnormal_olfactory_placode0.55928898
115MP0010769_abnormal_survival0.55331405
116MP0008004_abnormal_stomach_pH0.55185503
117MP0003123_paternal_imprinting0.54273592
118MP0004233_abnormal_muscle_weight0.54249550
119MP0003634_abnormal_glial_cell0.52795164
120MP0010768_mortality/aging0.52494929
121MP0003646_muscle_fatigue0.51280054
122MP0002751_abnormal_autonomic_nervous0.49848442
123* MP0003956_abnormal_body_size0.47839301
124MP0003137_abnormal_impulse_conducting0.47103592

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)9.53696722
2Epileptic encephalopathy (HP:0200134)6.24351141
3Hyperventilation (HP:0002883)6.03078671
4Atonic seizures (HP:0010819)6.01583646
5Focal seizures (HP:0007359)6.00563084
6Febrile seizures (HP:0002373)5.38472540
7Myokymia (HP:0002411)4.90112979
8Abnormal ciliary motility (HP:0012262)4.76151432
9Absence seizures (HP:0002121)4.67535648
10Abnormal respiratory epithelium morphology (HP:0012253)4.63106787
11Abnormal respiratory motile cilium morphology (HP:0005938)4.63106787
12Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.60730467
13Abnormal respiratory motile cilium physiology (HP:0012261)4.54664323
14Visual hallucinations (HP:0002367)4.44770880
15Dialeptic seizures (HP:0011146)4.42260569
16Broad-based gait (HP:0002136)4.19511243
17Rhinitis (HP:0012384)4.18027530
18Progressive cerebellar ataxia (HP:0002073)4.13440818
19Generalized tonic-clonic seizures (HP:0002069)3.94883821
20Abnormal hair whorl (HP:0010721)3.37793474
21Poor eye contact (HP:0000817)3.26713302
22Amblyopia (HP:0000646)3.23182991
23Drooling (HP:0002307)3.14777373
24Excessive salivation (HP:0003781)3.14777373
25* Gaze-evoked nystagmus (HP:0000640)3.12341956
26Dysdiadochokinesis (HP:0002075)3.10601088
27Protruding tongue (HP:0010808)3.10384811
28Abnormal eating behavior (HP:0100738)3.07674546
29Epileptiform EEG discharges (HP:0011182)3.06883931
30Impaired vibration sensation in the lower limbs (HP:0002166)3.02436379
31Absent speech (HP:0001344)2.90581842
32Pancreatic fibrosis (HP:0100732)2.90256494
33Abnormal social behavior (HP:0012433)2.89304292
34Impaired social interactions (HP:0000735)2.89304292
35Inability to walk (HP:0002540)2.77155444
36Gait imbalance (HP:0002141)2.72565210
37Action tremor (HP:0002345)2.71308535
38Polyphagia (HP:0002591)2.70337327
39EEG with generalized epileptiform discharges (HP:0011198)2.68447139
40Blue irides (HP:0000635)2.61547264
41Anxiety (HP:0000739)2.60727021
42Bronchiectasis (HP:0002110)2.55442051
43Urinary bladder sphincter dysfunction (HP:0002839)2.53525931
44Pheochromocytoma (HP:0002666)2.52325826
45Scanning speech (HP:0002168)2.50436843
46Hypsarrhythmia (HP:0002521)2.49643678
47Nephrogenic diabetes insipidus (HP:0009806)2.48629362
48Nephronophthisis (HP:0000090)2.47342648
49Papilledema (HP:0001085)2.47290158
50Fetal akinesia sequence (HP:0001989)2.46744729
51Congenital primary aphakia (HP:0007707)2.45912729
52Chronic bronchitis (HP:0004469)2.44742487
53Abnormality of the labia minora (HP:0012880)2.44069906
54Increased circulating renin level (HP:0000848)2.43397990
55Dysmetria (HP:0001310)2.43183189
56Medial flaring of the eyebrow (HP:0010747)2.42150359
57True hermaphroditism (HP:0010459)2.39398631
58Progressive inability to walk (HP:0002505)2.39077416
59Diplopia (HP:0000651)2.38549454
60Abnormality of binocular vision (HP:0011514)2.38549454
61* Truncal ataxia (HP:0002078)2.37524665
62Abnormality of the lower motor neuron (HP:0002366)2.35102231
63Decreased circulating renin level (HP:0003351)2.35012143
64Genetic anticipation (HP:0003743)2.34379003
65Supranuclear gaze palsy (HP:0000605)2.32377911
66Intention tremor (HP:0002080)2.31075186
67Abnormality of midbrain morphology (HP:0002418)2.29883644
68Molar tooth sign on MRI (HP:0002419)2.29883644
69Neuroendocrine neoplasm (HP:0100634)2.28766226
70Stereotypic behavior (HP:0000733)2.28765262
71Hyperthyroidism (HP:0000836)2.27618307
72Insidious onset (HP:0003587)2.25915131
73Termporal pattern (HP:0011008)2.25915131
74Pancreatic cysts (HP:0001737)2.25232551
75Ankle clonus (HP:0011448)2.22253582
76Status epilepticus (HP:0002133)2.20358347
77Infertility (HP:0000789)2.19300712
78Specific learning disability (HP:0001328)2.19131214
79Hemiparesis (HP:0001269)2.18076810
80Narrow nasal bridge (HP:0000446)2.17870541
81Akinesia (HP:0002304)2.15132614
82Cystic liver disease (HP:0006706)2.15059798
83* Depression (HP:0000716)2.14635625
84Fair hair (HP:0002286)2.12415287
85Poor suck (HP:0002033)2.11234238
86Bradykinesia (HP:0002067)2.10313832
87Abnormality of the corticospinal tract (HP:0002492)2.09740048
88Incomplete penetrance (HP:0003829)2.09431950
89Resting tremor (HP:0002322)2.09220085
90Abnormality of salivation (HP:0100755)2.07716982
91Limb dystonia (HP:0002451)2.05847324
92Generalized hypopigmentation of hair (HP:0011358)2.05063890
93Mutism (HP:0002300)2.04657947
94Failure to thrive in infancy (HP:0001531)2.04573809
95Spastic gait (HP:0002064)2.04393935
96Thickened helices (HP:0000391)2.04359571
97Occipital encephalocele (HP:0002085)2.01758695
98Hyperinsulinemic hypoglycemia (HP:0000825)2.00834419
99Urinary urgency (HP:0000012)1.98118803
100Postural instability (HP:0002172)1.96997201
101Oligomenorrhea (HP:0000876)1.96371084
102Hypoglycemic seizures (HP:0002173)1.95680498
103Hypoventilation (HP:0002791)1.93244088
104Hypoglycemic coma (HP:0001325)1.92712599
105Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.92130288
106Torticollis (HP:0000473)1.90844180
107* Impaired smooth pursuit (HP:0007772)1.88223104
108Absent/shortened dynein arms (HP:0200106)1.87999514
109Dynein arm defect of respiratory motile cilia (HP:0012255)1.87999514
110Poor coordination (HP:0002370)1.87732597
111Ventricular fibrillation (HP:0001663)1.87601483
112Agitation (HP:0000713)1.87203866
113Focal dystonia (HP:0004373)1.86467876
114Abnormality of the renal medulla (HP:0100957)1.85909170
115Generalized myoclonic seizures (HP:0002123)1.85286438
116Prolonged QT interval (HP:0001657)1.83858490
117Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.83462841
118Degeneration of the lateral corticospinal tracts (HP:0002314)1.83462841
119Aplasia/Hypoplasia of the tongue (HP:0010295)1.82367525
120Sleep apnea (HP:0010535)1.82284409
121Postaxial hand polydactyly (HP:0001162)1.79955903
122Hyperactive renin-angiotensin system (HP:0000841)1.79801684
123Esotropia (HP:0000565)1.78673623
124Genital tract atresia (HP:0001827)1.78515630
125Exotropia (HP:0000577)1.77865066
126Vaginal atresia (HP:0000148)1.76032516
127* Impaired vibratory sensation (HP:0002495)1.75746931
128Lower limb muscle weakness (HP:0007340)1.75389016
129Acute necrotizing encephalopathy (HP:0006965)1.74846498
130Open mouth (HP:0000194)1.74484786
131Hemiplegia (HP:0002301)1.74176264
132Diminished movement (HP:0002374)1.73282106
133Progressive macrocephaly (HP:0004481)1.71845738
134Supernumerary spleens (HP:0009799)1.71103904
135Abnormal mitochondria in muscle tissue (HP:0008316)1.70705397
136* Abnormality of ocular smooth pursuit (HP:0000617)1.70534124
137Craniofacial dystonia (HP:0012179)1.69864088
138Aplasia/Hypoplasia of the lens (HP:0008063)1.69280065
139Abnormality of renin-angiotensin system (HP:0000847)1.65206461
140Bundle branch block (HP:0011710)1.65164886

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK6.06673077
2FRK4.06190024
3NTRK33.90326958
4EPHA43.44413651
5MAP3K43.16850741
6MAP2K73.11638443
7CDK193.04381987
8MAP3K122.86251631
9DAPK22.74620449
10AKT32.43343369
11PLK22.32757944
12MARK12.20435492
13DAPK12.15554437
14PRPF4B2.13227853
15MAP3K92.01557598
16CCNB12.00643903
17MAP2K41.92768738
18MINK11.90059417
19PINK11.76675985
20OXSR11.69942297
21NTRK21.64357921
22CAMKK21.63990264
23RIPK41.60573803
24TNIK1.60001802
25FGFR21.45495238
26MAPK131.44039255
27KSR11.42198399
28MAPK151.41708350
29SGK21.40270091
30SIK31.36362323
31GRK51.35935986
32PAK61.33546597
33SGK2231.25214655
34SGK4941.25214655
35TSSK61.22665843
36CAMKK11.21778837
37PRKCG1.21215089
38CDK51.20472966
39PNCK1.14477161
40LIMK11.09733791
41ERBB31.08774430
42CAMK2A1.07361081
43CSNK1G31.07324784
44ARAF1.05748177
45MAP4K21.03971694
46CSNK1A1L1.01090947
47CSNK1G10.99865606
48CAMK2B0.97895542
49PTK2B0.96275095
50STK390.94937052
51BRAF0.91347325
52KSR20.90595521
53SGK30.89909898
54BMPR20.89497985
55FES0.86709628
56WNK10.80613374
57CDK180.79158261
58NME10.78378923
59PDK40.77791891
60PDK30.77791891
61PRKCE0.76621885
62NTRK10.75403147
63LATS20.75198483
64UHMK10.73891238
65SIK20.73494378
66BCR0.73271918
67SGK10.71646353
68CDK150.71205592
69PKN10.70197929
70NEK60.68909810
71CDK140.66447393
72CAMK10.65633107
73STK38L0.65621250
74DYRK20.65137068
75GRK10.64838047
76STK110.63495288
77WNK30.62475168
78CDK30.61793372
79WNK40.60931698
80FGR0.60574496
81CDK11A0.60364352
82TRPM70.60037712
83DYRK1A0.59063967
84RAF10.56041791
85DAPK30.55823145
86CSNK1D0.54825255
87STK240.54504803
88CAMK40.54392322
89BMPR1B0.54196690
90MARK20.53899066
91ADRBK10.51193538
92STK380.51178210
93MAP2K60.51020989
94PRKAA10.50830377
95CAMK2G0.50377307
96MAPK70.49336109
97ADRBK20.48273738
98CAMK2D0.47849109
99MAP3K20.47721930
100PRKCH0.47453781
101MAP3K130.47033316
102CSNK1G20.46183014
103PRKCI0.45625580
104FER0.44290083
105MAP3K60.43898269
106PRKCA0.42971101
107PDK20.42467021
108PHKG20.42343248
109PHKG10.42343248
110MAPK120.42221696
111PDK10.41280287
112GRK70.41232718
113PDPK10.41131823
114MAP2K10.39617554
115CSNK1E0.38146615
116TNK20.38090660
117PRKACB0.37750951
118INSRR0.36390956
119MUSK0.36324822
120RPS6KA30.36096486
121PRKD30.32810451
122PRKACA0.32724814
123ROCK20.31741926
124MYLK0.31653849
125PAK30.30834262
126YES10.30246269
127PRKG10.30150957
128RET0.30027436
129PRKCB0.29520939
130PRKCZ0.29259602

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.57387310
2Synaptic vesicle cycle_Homo sapiens_hsa047213.82845113
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.02393585
4Collecting duct acid secretion_Homo sapiens_hsa049662.81092374
5Morphine addiction_Homo sapiens_hsa050322.79308256
6GABAergic synapse_Homo sapiens_hsa047272.78517461
7Circadian entrainment_Homo sapiens_hsa047132.71991625
8Amphetamine addiction_Homo sapiens_hsa050312.70859521
9Long-term potentiation_Homo sapiens_hsa047202.69158231
10Olfactory transduction_Homo sapiens_hsa047402.63604889
11Glutamatergic synapse_Homo sapiens_hsa047242.61173544
12Taste transduction_Homo sapiens_hsa047422.24443935
13Dopaminergic synapse_Homo sapiens_hsa047282.15688151
14Salivary secretion_Homo sapiens_hsa049702.07037630
15Maturity onset diabetes of the young_Homo sapiens_hsa049502.06287691
16Insulin secretion_Homo sapiens_hsa049111.88880057
17Long-term depression_Homo sapiens_hsa047301.85027241
18Serotonergic synapse_Homo sapiens_hsa047261.83768003
19Renin secretion_Homo sapiens_hsa049241.83361052
20Vibrio cholerae infection_Homo sapiens_hsa051101.67867680
21Calcium signaling pathway_Homo sapiens_hsa040201.67398856
22Cocaine addiction_Homo sapiens_hsa050301.66958820
23Cholinergic synapse_Homo sapiens_hsa047251.66827195
24Gastric acid secretion_Homo sapiens_hsa049711.59901128
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.56404248
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.55598852
27Oxytocin signaling pathway_Homo sapiens_hsa049211.55510543
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.48928978
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.36284351
30Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.35676010
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.26240178
32Gap junction_Homo sapiens_hsa045401.24150127
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.23716857
34cAMP signaling pathway_Homo sapiens_hsa040241.23040714
35Butanoate metabolism_Homo sapiens_hsa006501.21665058
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15586607
37Oxidative phosphorylation_Homo sapiens_hsa001901.15119560
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.13232857
39GnRH signaling pathway_Homo sapiens_hsa049121.13142314
40Phototransduction_Homo sapiens_hsa047441.12884239
41Axon guidance_Homo sapiens_hsa043601.06379648
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03123161
43cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98963258
44Type II diabetes mellitus_Homo sapiens_hsa049300.98366314
45Cardiac muscle contraction_Homo sapiens_hsa042600.97765593
46Estrogen signaling pathway_Homo sapiens_hsa049150.94421170
47ErbB signaling pathway_Homo sapiens_hsa040120.93511555
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90583787
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89221656
50Regulation of autophagy_Homo sapiens_hsa041400.88750897
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.88409756
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87775767
53Alzheimers disease_Homo sapiens_hsa050100.86818369
54Melanogenesis_Homo sapiens_hsa049160.83989805
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82148539
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.81478390
57Rheumatoid arthritis_Homo sapiens_hsa053230.80519342
58Glioma_Homo sapiens_hsa052140.79051711
59ABC transporters_Homo sapiens_hsa020100.76550415
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73228300
61Histidine metabolism_Homo sapiens_hsa003400.72758409
62beta-Alanine metabolism_Homo sapiens_hsa004100.71053980
63Pancreatic secretion_Homo sapiens_hsa049720.69850370
64Mineral absorption_Homo sapiens_hsa049780.68999249
65Protein export_Homo sapiens_hsa030600.68074706
66Parkinsons disease_Homo sapiens_hsa050120.67077544
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67056063
68Dilated cardiomyopathy_Homo sapiens_hsa054140.66177698
69Type I diabetes mellitus_Homo sapiens_hsa049400.63905065
70* MAPK signaling pathway_Homo sapiens_hsa040100.63320700
71Oocyte meiosis_Homo sapiens_hsa041140.62626276
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62161166
73Bile secretion_Homo sapiens_hsa049760.60185639
74Circadian rhythm_Homo sapiens_hsa047100.59985618
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57700423
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57467472
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55559588
78Ether lipid metabolism_Homo sapiens_hsa005650.53243275
79Thyroid hormone synthesis_Homo sapiens_hsa049180.53043945
80Glucagon signaling pathway_Homo sapiens_hsa049220.52745810
81Sphingolipid metabolism_Homo sapiens_hsa006000.52669821
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51679726
83Alcoholism_Homo sapiens_hsa050340.50983105
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49306531
85Phenylalanine metabolism_Homo sapiens_hsa003600.49030186
86Dorso-ventral axis formation_Homo sapiens_hsa043200.48593432
87Phagosome_Homo sapiens_hsa041450.47943459
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47120728
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.46953186
90Hedgehog signaling pathway_Homo sapiens_hsa043400.46719053
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46700931
92Inositol phosphate metabolism_Homo sapiens_hsa005620.46040214
93* Ras signaling pathway_Homo sapiens_hsa040140.45496897
94Tight junction_Homo sapiens_hsa045300.45061918
95Huntingtons disease_Homo sapiens_hsa050160.44783022
96Arginine biosynthesis_Homo sapiens_hsa002200.43024698
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41834005
98Choline metabolism in cancer_Homo sapiens_hsa052310.41429950
99Fatty acid biosynthesis_Homo sapiens_hsa000610.41421318
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40509925
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38502827
102Folate biosynthesis_Homo sapiens_hsa007900.38091373
103Chemical carcinogenesis_Homo sapiens_hsa052040.35135558
104African trypanosomiasis_Homo sapiens_hsa051430.35006040
105Hippo signaling pathway_Homo sapiens_hsa043900.34839148
106* Rap1 signaling pathway_Homo sapiens_hsa040150.34822032
107Wnt signaling pathway_Homo sapiens_hsa043100.33950487
108Linoleic acid metabolism_Homo sapiens_hsa005910.33796747
109Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.33604504
110Peroxisome_Homo sapiens_hsa041460.33399169
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32974179
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.31216028
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30758353
114Ovarian steroidogenesis_Homo sapiens_hsa049130.29073501
1152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.26507825
116Insulin signaling pathway_Homo sapiens_hsa049100.26297989
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25585156
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23734799
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23596566
120Endometrial cancer_Homo sapiens_hsa052130.23125781
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22455733
122Renal cell carcinoma_Homo sapiens_hsa052110.22123618
123Colorectal cancer_Homo sapiens_hsa052100.21820923
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.20028521
125Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.18666197
126mTOR signaling pathway_Homo sapiens_hsa041500.18535100
127VEGF signaling pathway_Homo sapiens_hsa043700.18230605

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