FGF17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the fibroblast growth factor (FGF) family. Member of the FGF family possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is expressed during embryogenesis and in the adult cerebellum and cortex and may be essential for vascular growth and normal brain development. Mutations in this gene are the cause of hypogonadotropic hypogonadism 20 with or without anosmia. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell migration involved in gastrulation (GO:0042074)8.89865226
2signal transduction involved in regulation of gene expression (GO:0023019)7.46219382
3negative regulation of activin receptor signaling pathway (GO:0032926)7.44771356
4regulation of Wnt signaling pathway involved in heart development (GO:0003307)7.12426427
5regulation of posttranscriptional gene silencing (GO:0060147)6.95327017
6regulation of gene silencing by miRNA (GO:0060964)6.95327017
7regulation of gene silencing by RNA (GO:0060966)6.95327017
8receptor guanylyl cyclase signaling pathway (GO:0007168)6.74074396
9muscle organ morphogenesis (GO:0048644)6.46662830
10positive regulation of urine volume (GO:0035810)5.94004965
11endoderm formation (GO:0001706)5.65479974
12embryonic foregut morphogenesis (GO:0048617)5.59166380
13negative regulation of cell fate specification (GO:0009996)5.17967154
14nuclear pore organization (GO:0006999)5.17442950
15digestive tract morphogenesis (GO:0048546)5.06282941
16positive regulation of renal sodium excretion (GO:0035815)5.00258185
17DNA unwinding involved in DNA replication (GO:0006268)4.99476100
18DNA replication initiation (GO:0006270)4.98639979
19sequestering of extracellular ligand from receptor (GO:0035581)4.94280274
20regulation of activin receptor signaling pathway (GO:0032925)4.88452319
21pre-miRNA processing (GO:0031054)4.83237944
22regulation of cardioblast differentiation (GO:0051890)4.82171429
23transcytosis (GO:0045056)4.78725241
24SMAD protein signal transduction (GO:0060395)4.72816876
25dorsal/ventral neural tube patterning (GO:0021904)4.71465393
26folic acid-containing compound biosynthetic process (GO:0009396)4.69266711
27atrioventricular valve morphogenesis (GO:0003181)4.68274310
28nuclear pore complex assembly (GO:0051292)4.67303171
29DNA replication-dependent nucleosome organization (GO:0034723)4.67225364
30DNA replication-dependent nucleosome assembly (GO:0006335)4.67225364
31IMP biosynthetic process (GO:0006188)4.55442808
32regulation of helicase activity (GO:0051095)4.52576790
33regulation of gastrulation (GO:0010470)4.49383999
34phenol-containing compound catabolic process (GO:0019336)4.48413635
35cellular response to BMP stimulus (GO:0071773)4.45102071
36response to BMP (GO:0071772)4.45102071
37paraxial mesoderm development (GO:0048339)4.45053696
38neural crest cell development (GO:0014032)4.41280765
39cGMP biosynthetic process (GO:0006182)4.37041343
40nucleobase biosynthetic process (GO:0046112)4.30939385
41retinoic acid receptor signaling pathway (GO:0048384)4.30273900
42DNA strand elongation involved in DNA replication (GO:0006271)4.28919290
43hormone catabolic process (GO:0042447)4.26317469
44somatic diversification of immune receptors via somatic mutation (GO:0002566)4.25158801
45somatic hypermutation of immunoglobulin genes (GO:0016446)4.25158801
46regulation of glucocorticoid metabolic process (GO:0031943)4.21789205
47ribosome assembly (GO:0042255)4.17401316
48mitotic nuclear envelope disassembly (GO:0007077)4.14042135
49primitive streak formation (GO:0090009)4.12763280
50regulation of urine volume (GO:0035809)4.11403015
51IMP metabolic process (GO:0046040)4.11178970
52retinoic acid metabolic process (GO:0042573)4.10931623
53histone arginine methylation (GO:0034969)4.10235019
54gastrulation (GO:0007369)4.06479282
55DNA strand elongation (GO:0022616)4.04317985
56protein localization to kinetochore (GO:0034501)4.02024443
57anterior/posterior axis specification, embryo (GO:0008595)4.01471023
58formation of translation preinitiation complex (GO:0001731)4.00166005
59maturation of SSU-rRNA (GO:0030490)3.96737579
60regulation of gene silencing (GO:0060968)3.92838684
61heterochromatin organization (GO:0070828)3.90366497
62purine nucleobase biosynthetic process (GO:0009113)3.89654622
63nuclear envelope disassembly (GO:0051081)3.85023922
64membrane disassembly (GO:0030397)3.85023922
65lung morphogenesis (GO:0060425)3.82924403
66mitotic metaphase plate congression (GO:0007080)3.78035904
67telomere maintenance via semi-conservative replication (GO:0032201)3.77770840
68mating behavior (GO:0007617)3.77001853
69cardiac muscle hypertrophy in response to stress (GO:0014898)3.76664165
70muscle hypertrophy in response to stress (GO:0003299)3.76664165
71cardiac muscle adaptation (GO:0014887)3.76664165
72peptidyl-arginine omega-N-methylation (GO:0035247)3.75127928
73ribosome biogenesis (GO:0042254)3.74918967
74negative regulation of cell fate commitment (GO:0010454)3.72287497
75dorsal/ventral axis specification (GO:0009950)3.70515413
76positive regulation of SMAD protein import into nucleus (GO:0060391)3.67734544
77establishment of integrated proviral latency (GO:0075713)3.64758247
78regulation of translational fidelity (GO:0006450)3.63572537
79anterior/posterior axis specification (GO:0009948)3.59818326
80regulation of histone H3-K9 methylation (GO:0051570)3.53508307
81DNA duplex unwinding (GO:0032508)3.53368520
82organ formation (GO:0048645)3.52743023
83DNA geometric change (GO:0032392)3.51934536
84negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.50936238
85regulation of translational termination (GO:0006449)3.48550622
86mitotic sister chromatid segregation (GO:0000070)3.47415189
87somite rostral/caudal axis specification (GO:0032525)3.43251492
88ribonucleoprotein complex biogenesis (GO:0022613)3.42241268
89pore complex assembly (GO:0046931)3.39689960
90renal system development (GO:0072001)3.37696696
91nodal signaling pathway (GO:0038092)3.35180495
92ribosomal large subunit biogenesis (GO:0042273)3.34443910
93embryonic axis specification (GO:0000578)3.32748435
94determination of adult lifespan (GO:0008340)3.32072353
95negative regulation of hormone biosynthetic process (GO:0032353)3.30218803
96protein localization to chromosome, centromeric region (GO:0071459)3.30159376
97regulation of development, heterochronic (GO:0040034)3.27701897
98establishment of apical/basal cell polarity (GO:0035089)3.26919156
99DNA replication checkpoint (GO:0000076)3.26918842
100regulation of hippo signaling (GO:0035330)3.26565855
101histone H4-K12 acetylation (GO:0043983)3.25959371
102potassium ion homeostasis (GO:0055075)3.25913370
103metaphase plate congression (GO:0051310)3.25791408
104positive regulation of gastrulation (GO:2000543)3.24087731
105regulation of timing of cell differentiation (GO:0048505)3.23634438
106negative regulation of gene silencing (GO:0060969)3.23524172
107chromatin remodeling at centromere (GO:0031055)3.22910222
108cGMP metabolic process (GO:0046068)3.22328422
109negative regulation of histone methylation (GO:0031061)3.21971292
110female gonad development (GO:0008585)3.21108072
111regulation of stem cell maintenance (GO:2000036)3.19847720
112spliceosomal snRNP assembly (GO:0000387)3.19282275
113protein K6-linked ubiquitination (GO:0085020)3.17477419
114telomere maintenance via recombination (GO:0000722)3.15879995
115mesenchymal cell development (GO:0014031)3.15576949
116telomere maintenance via telomere lengthening (GO:0010833)3.15493242
117collecting duct development (GO:0072044)3.14601184
118mismatch repair (GO:0006298)3.14144827
119peptidyl-arginine N-methylation (GO:0035246)3.13967494
120peptidyl-arginine methylation (GO:0018216)3.13967494
121regulation of vascular permeability (GO:0043114)3.13126788
122regulation of renal sodium excretion (GO:0035813)3.10830930
123regulation of excretion (GO:0044062)3.10138029
124regulation of nuclear cell cycle DNA replication (GO:0033262)3.09876430
125spliceosomal tri-snRNP complex assembly (GO:0000244)3.09690620
126mitotic recombination (GO:0006312)3.08965920
127rRNA processing (GO:0006364)3.08913172
128cell migration in hindbrain (GO:0021535)3.08820213
129regulation of centrosome cycle (GO:0046605)3.07915633
130pericardium development (GO:0060039)3.07817953
131regulation of cell fate specification (GO:0042659)3.05344417
132ectodermal placode formation (GO:0060788)3.04845035
133phagocytosis, recognition (GO:0006910)3.04493618
134regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.02899939
135sister chromatid segregation (GO:0000819)3.01132832
136L-ascorbic acid metabolic process (GO:0019852)3.00337880
137positive regulation of chromosome segregation (GO:0051984)3.00025925
138ncRNA catabolic process (GO:0034661)2.99744863
139regulation of SMAD protein import into nucleus (GO:0060390)2.99689021
140rRNA metabolic process (GO:0016072)2.99098069
141amino acid import (GO:0043090)2.98975738
142protein complex localization (GO:0031503)2.98551858
143translational termination (GO:0006415)2.98440226
144CENP-A containing nucleosome assembly (GO:0034080)2.98362293
145viral transcription (GO:0019083)2.97748504
146nucleotide-excision repair, DNA gap filling (GO:0006297)2.96865459
147regulation of centriole replication (GO:0046599)2.96575301
148vocalization behavior (GO:0071625)2.96490271
149translational initiation (GO:0006413)2.96410446
150regulation of spindle organization (GO:0090224)2.96088547
151positive regulation of cardiac muscle cell proliferation (GO:0060045)2.95217055
152ribosomal small subunit biogenesis (GO:0042274)2.94262624
153spliceosomal complex assembly (GO:0000245)2.93432194
154synaptic vesicle docking involved in exocytosis (GO:0016081)2.93142060
155embryonic pattern specification (GO:0009880)2.91426957
156chaperone-mediated protein complex assembly (GO:0051131)2.89035181
157DNA replication-independent nucleosome organization (GO:0034724)2.88352539
158DNA replication-independent nucleosome assembly (GO:0006336)2.88352539
159negative regulation of androgen receptor signaling pathway (GO:0060766)2.87840073
160RNA splicing, via transesterification reactions (GO:0000375)2.86248851
161regulation of mitotic spindle organization (GO:0060236)2.86018050
162genitalia morphogenesis (GO:0035112)2.84257956
163mRNA transport (GO:0051028)2.83822182
164translational elongation (GO:0006414)2.83708608
165mRNA splicing, via spliceosome (GO:0000398)2.83593632
166RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.83593632
167establishment of chromosome localization (GO:0051303)2.83134916
168positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.83099427
169polarized epithelial cell differentiation (GO:0030859)2.82335173
170pteridine-containing compound biosynthetic process (GO:0042559)2.82116886
171embryonic process involved in female pregnancy (GO:0060136)2.81851498
172regulation of mesoderm development (GO:2000380)2.81382721
173cellular modified amino acid catabolic process (GO:0042219)2.81097364
174regulation of retinoic acid receptor signaling pathway (GO:0048385)2.81023603
175L-amino acid import (GO:0043092)2.80941510
176G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.80755432
177embryonic heart tube development (GO:0035050)2.79785725
178embryonic camera-type eye development (GO:0031076)2.79586936
179regulation of cardiac muscle cell contraction (GO:0086004)2.79229310
180cardiocyte differentiation (GO:0035051)2.77812393
181regulation of transcription involved in cell fate commitment (GO:0060850)2.77538288
182maternal placenta development (GO:0001893)2.76605766
183thyroid hormone generation (GO:0006590)2.74003109
184negative regulation of hormone metabolic process (GO:0032351)2.73807515
185positive regulation of osteoblast proliferation (GO:0033690)2.72856839
186negative regulation of embryonic development (GO:0045992)2.72691811
187Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.71537965
188C4-dicarboxylate transport (GO:0015740)2.70759059
189cardiac muscle hypertrophy (GO:0003300)2.68448249
190positive regulation of cardiac muscle tissue growth (GO:0055023)2.64663072
191neuronal ion channel clustering (GO:0045161)2.63434168
192fat-soluble vitamin metabolic process (GO:0006775)2.62735962
193positive regulation of p38MAPK cascade (GO:1900745)2.62043912
194fat-soluble vitamin catabolic process (GO:0042363)11.2281942
195vitamin catabolic process (GO:0009111)11.2281942

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.31801483
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.34885933
3* SMAD3_21741376_ChIP-Seq_HESCs_Human3.93380904
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.70653025
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.60550597
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.60550597
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.60550597
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.52008940
9MYC_19079543_ChIP-ChIP_MESCs_Mouse3.45941391
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.20902946
11* SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.02013676
12POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.97362743
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.90377940
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.89092364
15* SMAD4_21741376_ChIP-Seq_HESCs_Human2.81545958
16EOMES_21245162_ChIP-Seq_HESCs_Human2.72479289
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.58501223
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.54242229
19NANOG_18555785_ChIP-Seq_MESCs_Mouse2.52982373
20NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.51914457
21NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.46226565
22* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.38239624
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.25692773
24MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.23835899
25ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.23536471
26POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.22763731
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.21430228
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.17494786
29EZH2_27304074_Chip-Seq_ESCs_Mouse2.14213922
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.13691079
31EST1_17652178_ChIP-ChIP_JURKAT_Human2.09260280
32XRN2_22483619_ChIP-Seq_HELA_Human2.08111968
33POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.07079619
34SOX2_18555785_ChIP-Seq_MESCs_Mouse2.05508703
35KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.03496698
36STAT3_1855785_ChIP-Seq_MESCs_Mouse2.03015150
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.02675612
38ETS1_20019798_ChIP-Seq_JURKAT_Human2.01679250
39ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.01027912
40* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.98448799
41SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.96599531
42SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.96132375
43SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.93363349
44HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.92827992
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.89263934
46EZH2_18974828_ChIP-Seq_MESCs_Mouse1.82593175
47RNF2_18974828_ChIP-Seq_MESCs_Mouse1.82593175
48KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.80475833
49SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.80062155
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78095318
51MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.77790460
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.76585435
53JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.76501136
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.75809466
55AR_21909140_ChIP-Seq_LNCAP_Human1.75692157
56PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.75212288
57SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.70725691
58SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.68646112
59CREB1_15753290_ChIP-ChIP_HEK293T_Human1.66260483
60ERG_21242973_ChIP-ChIP_JURKAT_Human1.65729705
61KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.65469230
62CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.63870020
63RNF2_27304074_Chip-Seq_ESCs_Mouse1.63797329
64E2F1_21310950_ChIP-Seq_MCF-7_Human1.63087668
65NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.62039536
66KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.61872929
67THAP11_20581084_ChIP-Seq_MESCs_Mouse1.60545872
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.58423481
69RING1B_27294783_Chip-Seq_ESCs_Mouse1.58261767
70ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.57529036
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.56985865
72GABP_17652178_ChIP-ChIP_JURKAT_Human1.56215481
73JARID2_20064375_ChIP-Seq_MESCs_Mouse1.55140920
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.53107893
75* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.52922789
76SALL1_21062744_ChIP-ChIP_HESCs_Human1.50597214
77JARID2_20075857_ChIP-Seq_MESCs_Mouse1.49742316
78NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.49624725
79EGR1_19374776_ChIP-ChIP_THP-1_Human1.48647103
80TTF2_22483619_ChIP-Seq_HELA_Human1.48085723
81NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.47902250
82ESR1_15608294_ChIP-ChIP_MCF-7_Human1.46900957
83* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.46627586
84SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.46160656
85NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.45481971
86EZH2_27294783_Chip-Seq_ESCs_Mouse1.44145744
87* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.40392720
88* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.35318302
89* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.34497980
90YY1_21170310_ChIP-Seq_MESCs_Mouse1.33962577
91GATA1_26923725_Chip-Seq_HPCs_Mouse1.33286852
92KLF4_18555785_ChIP-Seq_MESCs_Mouse1.33221893
93SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.32528698
94TP53_20018659_ChIP-ChIP_R1E_Mouse1.31842058
95VDR_23849224_ChIP-Seq_CD4+_Human1.30049015
96EZH2_22144423_ChIP-Seq_EOC_Human1.29703885
97MYC_22102868_ChIP-Seq_BL_Human1.27877630
98SUZ12_27294783_Chip-Seq_ESCs_Mouse1.27763619
99NANOG_21062744_ChIP-ChIP_HESCs_Human1.26393686
100TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.26261571
101MTF2_20144788_ChIP-Seq_MESCs_Mouse1.24996147
102ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23766407
103YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22575257
104WT1_19549856_ChIP-ChIP_CCG9911_Human1.22004662
105CTCF_27219007_Chip-Seq_Bcells_Human1.21852957
106CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21177858
107FOXP3_21729870_ChIP-Seq_TREG_Human1.21088966
108GABP_19822575_ChIP-Seq_HepG2_Human1.20977195
109* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.20225061
110DCP1A_22483619_ChIP-Seq_HELA_Human1.20099819
111TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18342423
112* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.17526801
113TP63_19390658_ChIP-ChIP_HaCaT_Human1.12762430
114TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.12759255
115RNF2_27304074_Chip-Seq_NSC_Mouse1.10916882
116EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10287039
117SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08876280
118ZFP281_18757296_ChIP-ChIP_E14_Mouse1.08707506
119MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08269753
120KDM5A_27292631_Chip-Seq_BREAST_Human1.07426283
121FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.06467495
122SALL4_18804426_ChIP-ChIP_XEN_Mouse1.06337303
123MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05274172
124POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.04140771
125TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.04131755
126SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.03684069
127RING1B_27294783_Chip-Seq_NPCs_Mouse1.03541607
128SMAD4_21741376_ChIP-Seq_EPCs_Human1.02216503
129CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01289181
130ELK1_19687146_ChIP-ChIP_HELA_Human1.00261324
131RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00111136
132NANOG_16153702_ChIP-ChIP_HESCs_Human0.99774303
133ISL1_27105846_Chip-Seq_CPCs_Mouse0.99399724
134ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99147011
135NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.99128758
136PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98165339
137CIITA_25753668_ChIP-Seq_RAJI_Human0.98052350
138KAP1_27257070_Chip-Seq_ESCs_Mouse0.98046371
139P300_19829295_ChIP-Seq_ESCs_Human0.97961025
140SOX2_16153702_ChIP-ChIP_HESCs_Human0.96022831
141REST_18959480_ChIP-ChIP_MESCs_Mouse0.95982226
142HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.95735972
143DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94614764
144HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94045006
145REST_21632747_ChIP-Seq_MESCs_Mouse0.93189573
146TFEB_21752829_ChIP-Seq_HELA_Human0.91769604
147CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91284844
148SMAD3_21741376_ChIP-Seq_ESCs_Human0.89677938
149NANOG_16518401_ChIP-PET_MESCs_Mouse0.86695198
150ZFP281_27345836_Chip-Seq_ESCs_Mouse0.85988378
151PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.85059053
152SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.83888258
153OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.82854291
154BMI1_23680149_ChIP-Seq_NPCS_Mouse0.82675573
155CTBP1_25329375_ChIP-Seq_LNCAP_Human0.82205085
156CBX2_27304074_Chip-Seq_ESCs_Mouse0.80086094
157ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79301975
158* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.78393930
159WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.76226649
160TBX3_20139965_ChIP-Seq_ESCs_Mouse0.75618193
161LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75557676
162TBX3_20139965_ChIP-Seq_MESCs_Mouse0.75241236
163KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.74123072
164ESR1_21235772_ChIP-Seq_MCF-7_Human0.73191293
165ZNF263_19887448_ChIP-Seq_K562_Human0.72748289
166P53_22127205_ChIP-Seq_FIBROBLAST_Human0.71059208
167IRF1_19129219_ChIP-ChIP_H3396_Human0.70443490
168KDM2B_26808549_Chip-Seq_REH_Human0.69865724

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004957_abnormal_blastocyst_morpholog4.23459044
2MP0003693_abnormal_embryo_hatching4.23232255
3MP0008057_abnormal_DNA_replication3.99486514
4MP0010094_abnormal_chromosome_stability3.91885843
5MP0003111_abnormal_nucleus_morphology3.77742442
6MP0003122_maternal_imprinting3.47954557
7MP0005499_abnormal_olfactory_system3.41607556
8MP0005394_taste/olfaction_phenotype3.41607556
9MP0004133_heterotaxia3.36021310
10MP0003077_abnormal_cell_cycle3.35781083
11MP0008004_abnormal_stomach_pH3.30014031
12MP0003123_paternal_imprinting3.21532556
13MP0003806_abnormal_nucleotide_metabolis3.21187464
14MP0008058_abnormal_DNA_repair2.84382719
15MP0003283_abnormal_digestive_organ2.68584806
16MP0010352_gastrointestinal_tract_polyps2.60006038
17MP0001730_embryonic_growth_arrest2.57870428
18MP0008932_abnormal_embryonic_tissue2.44608857
19MP0002653_abnormal_ependyma_morphology2.39264964
20MP0008007_abnormal_cellular_replicative2.28569870
21MP0010030_abnormal_orbit_morphology2.25335464
22MP0000350_abnormal_cell_proliferation2.23422853
23MP0003119_abnormal_digestive_system2.20225768
24MP0000462_abnormal_digestive_system2.17166436
25MP0002163_abnormal_gland_morphology2.13219411
26MP0002085_abnormal_embryonic_tissue2.11484509
27MP0002084_abnormal_developmental_patter2.08959372
28MP0001672_abnormal_embryogenesis/_devel1.98870251
29MP0005380_embryogenesis_phenotype1.98870251
30MP0003136_yellow_coat_color1.97265388
31MP0001697_abnormal_embryo_size1.95096150
32MP0003890_abnormal_embryonic-extraembry1.92543672
33MP0004197_abnormal_fetal_growth/weight/1.92507445
34MP0001293_anophthalmia1.91662650
35MP0003880_abnormal_central_pattern1.80681044
36MP0002736_abnormal_nociception_after1.74972218
37MP0002086_abnormal_extraembryonic_tissu1.73058335
38MP0003385_abnormal_body_wall1.72479531
39MP0002277_abnormal_respiratory_mucosa1.68996949
40MP0003941_abnormal_skin_development1.68542751
41MP0000537_abnormal_urethra_morphology1.66018659
42MP0003315_abnormal_perineum_morphology1.65897668
43MP0002080_prenatal_lethality1.63566837
44MP0006292_abnormal_olfactory_placode1.62937474
45MP0003984_embryonic_growth_retardation1.62676718
46MP0003121_genomic_imprinting1.61950913
47MP0004859_abnormal_synaptic_plasticity1.61678465
48MP0001849_ear_inflammation1.61187202
49MP0010307_abnormal_tumor_latency1.60949363
50MP0002088_abnormal_embryonic_growth/wei1.59584829
51MP0009053_abnormal_anal_canal1.52908527
52MP0002233_abnormal_nose_morphology1.52358467
53MP0005076_abnormal_cell_differentiation1.45842157
54MP0008877_abnormal_DNA_methylation1.43333741
55MP0002111_abnormal_tail_morphology1.41160098
56MP0001984_abnormal_olfaction1.40540251
57MP0003786_premature_aging1.39392004
58MP0000516_abnormal_urinary_system1.38454564
59MP0005367_renal/urinary_system_phenotyp1.38454564
60MP0003718_maternal_effect1.35711147
61MP0005379_endocrine/exocrine_gland_phen1.33090078
62MP0003937_abnormal_limbs/digits/tail_de1.32489487
63MP0003705_abnormal_hypodermis_morpholog1.27435117
64MP0003567_abnormal_fetal_cardiomyocyte1.25451205
65MP0001968_abnormal_touch/_nociception1.21998994
66MP0005084_abnormal_gallbladder_morpholo1.20272974
67MP0002249_abnormal_larynx_morphology1.14995475
68MP0008789_abnormal_olfactory_epithelium1.11255441
69MP0000313_abnormal_cell_death1.10962639
70MP0003566_abnormal_cell_adhesion1.07617520
71MP0009672_abnormal_birth_weight1.07362081
72MP0004233_abnormal_muscle_weight1.07304789
73MP0000372_irregular_coat_pigmentation1.07304371
74MP0002160_abnormal_reproductive_system1.07024580
75MP0003861_abnormal_nervous_system1.05682188
76MP0002210_abnormal_sex_determination1.05667125
77MP0005423_abnormal_somatic_nervous1.03047921
78MP0004270_analgesia1.02022431
79MP0001145_abnormal_male_reproductive1.01319873
80MP0002734_abnormal_mechanical_nocicepti1.01119917
81MP0005670_abnormal_white_adipose1.00585193
82MP0003635_abnormal_synaptic_transmissio0.99585908
83MP0000490_abnormal_crypts_of0.98427745
84MP0001286_abnormal_eye_development0.97970007
85MP0003632_abnormal_nervous_system0.97660764
86MP0001529_abnormal_vocalization0.96729567
87MP0002697_abnormal_eye_size0.92331356
88MP0000049_abnormal_middle_ear0.92323952
89MP0009703_decreased_birth_body0.91920787
90MP0002092_abnormal_eye_morphology0.90886567
91MP0000778_abnormal_nervous_system0.90446410
92MP0002019_abnormal_tumor_incidence0.90022995
93MP0005646_abnormal_pituitary_gland0.89771296
94MP0005266_abnormal_metabolism0.89031380
95MP0005501_abnormal_skin_physiology0.87384076
96MP0000432_abnormal_head_morphology0.86235708
97MP0003936_abnormal_reproductive_system0.85882982
98MP0008770_decreased_survivor_rate0.85261088
99MP0002114_abnormal_axial_skeleton0.81696887
100MP0002572_abnormal_emotion/affect_behav0.80354013
101MP0001348_abnormal_lacrimal_gland0.80220918
102MP0006054_spinal_hemorrhage0.79530843
103MP0002796_impaired_skin_barrier0.79398763
104MP0009384_cardiac_valve_regurgitation0.78767168
105MP0002132_abnormal_respiratory_system0.78557137
106MP0000428_abnormal_craniofacial_morphol0.77988601
107MP0003329_amyloid_beta_deposits0.77518400
108MP0005623_abnormal_meninges_morphology0.76608314
109MP0000653_abnormal_sex_gland0.76529140
110MP0002254_reproductive_system_inflammat0.75456411
111MP0002925_abnormal_cardiovascular_devel0.73803168
112MP0002928_abnormal_bile_duct0.72319455
113MP0003935_abnormal_craniofacial_develop0.71730627
114MP0005023_abnormal_wound_healing0.71707919
115MP0002127_abnormal_cardiovascular_syste0.71663223
116MP0001486_abnormal_startle_reflex0.71658461
117MP0005187_abnormal_penis_morphology0.71095767
118MP0001929_abnormal_gametogenesis0.69686214
119MP0000477_abnormal_intestine_morphology0.68117422
120MP0002751_abnormal_autonomic_nervous0.68093817
121MP0004264_abnormal_extraembryonic_tissu0.67524643
122MP0003115_abnormal_respiratory_system0.67341631
123MP0002932_abnormal_joint_morphology0.66294847
124MP0003950_abnormal_plasma_membrane0.66158110
125MP0003938_abnormal_ear_development0.65819585
126MP0004858_abnormal_nervous_system0.65735607
127MP0000678_abnormal_parathyroid_gland0.64108894
128MP0002090_abnormal_vision0.63793454
129MP0000762_abnormal_tongue_morphology0.63715456
130MP0003755_abnormal_palate_morphology0.63516652
131MP0010234_abnormal_vibrissa_follicle0.63292109
132MP0005384_cellular_phenotype0.62862281
133MP0003279_aneurysm0.62318490
134* MP0002152_abnormal_brain_morphology0.62294196
135MP0000566_synostosis0.62280473
136MP0003186_abnormal_redox_activity0.61940463
137MP0005389_reproductive_system_phenotype0.61695363
138MP0002064_seizures0.61576214
139MP0009745_abnormal_behavioral_response0.61555951
140MP0002557_abnormal_social/conspecific_i0.61539629
141MP0001915_intracranial_hemorrhage0.61337583
142MP0006072_abnormal_retinal_apoptosis0.56690873
143MP0001440_abnormal_grooming_behavior0.56445328
144MP0000358_abnormal_cell_content/0.56425735
145MP0003787_abnormal_imprinting0.52784875
146MP0000026_abnormal_inner_ear0.51852061
147MP0002272_abnormal_nervous_system0.49475959
148MP0004147_increased_porphyrin_level0.49064737
149MP0002752_abnormal_somatic_nervous0.48473820
150MP0002063_abnormal_learning/memory/cond0.47546378
151MP0003631_nervous_system_phenotype0.46897635
152MP0002938_white_spotting0.45504917
153MP0003943_abnormal_hepatobiliary_system0.44858708
154MP0004272_abnormal_basement_membrane0.44794843
155MP0002116_abnormal_craniofacial_bone0.44710722
156MP0005381_digestive/alimentary_phenotyp0.44430153
157MP0002081_perinatal_lethality0.43853832
158MP0000266_abnormal_heart_morphology0.43544637
159MP0002109_abnormal_limb_morphology0.42536961
160MP0002067_abnormal_sensory_capabilities0.42400877
161MP0003137_abnormal_impulse_conducting0.42039152
162MP0002234_abnormal_pharynx_morphology0.41374487
163MP0000955_abnormal_spinal_cord0.41348799
164MP0004885_abnormal_endolymph0.39671833
165MP0004381_abnormal_hair_follicle0.39544992

Predicted human phenotypes

RankGene SetZ-score
1Double outlet right ventricle (HP:0001719)5.62875343
2Congenital malformation of the right heart (HP:0011723)5.62875343
3Aplasia/Hypoplasia of the sacrum (HP:0008517)5.16277549
4Ependymoma (HP:0002888)5.13160608
5Oligodactyly (hands) (HP:0001180)4.94013621
6Periauricular skin pits (HP:0100277)4.52046209
7Preauricular pit (HP:0004467)4.52046209
8Abnormal ventriculo-arterial connection (HP:0011563)4.33449581
9Transposition of the great arteries (HP:0001669)4.33449581
10Abnormal connection of the cardiac segments (HP:0011545)4.33449581
11Medulloblastoma (HP:0002885)4.14594472
12Absent radius (HP:0003974)4.14286992
13Abnormality of the pubic bones (HP:0003172)4.11780603
14Abnormality of the labia minora (HP:0012880)4.08407716
15Selective tooth agenesis (HP:0001592)3.92635987
16Aplasia involving forearm bones (HP:0009822)3.91685591
17Absent forearm bone (HP:0003953)3.91685591
18Supernumerary spleens (HP:0009799)3.90177819
19Aplasia/hypoplasia of the humerus (HP:0006507)3.88859445
20Abnormality of the fetal cardiovascular system (HP:0010948)3.87543548
21Abnormal umbilical cord blood vessels (HP:0011403)3.87543548
22Single umbilical artery (HP:0001195)3.87543548
23Bifid tongue (HP:0010297)3.85857106
24Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)3.83412547
25Carpal bone hypoplasia (HP:0001498)3.82258337
26Birth length less than 3rd percentile (HP:0003561)3.73922676
27Rectal fistula (HP:0100590)3.72916413
28Rectovaginal fistula (HP:0000143)3.72916413
29Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.72619087
30Labial hypoplasia (HP:0000066)3.63983715
31Mixed hearing impairment (HP:0000410)3.63815727
32Short middle phalanx of the 5th finger (HP:0004220)3.61805412
33Abnormality of the astrocytes (HP:0100707)3.60442907
34Astrocytoma (HP:0009592)3.60442907
35Short humerus (HP:0005792)3.58389186
36Abdominal situs inversus (HP:0003363)3.56178122
37Abnormality of abdominal situs (HP:0011620)3.56178122
38Breast hypoplasia (HP:0003187)3.54106414
39Colon cancer (HP:0003003)3.53487208
40Oligodactyly (HP:0012165)3.47769104
41Abnormal pancreas size (HP:0012094)3.46038759
42Hypoplastic female external genitalia (HP:0012815)3.44405739
43Neoplasm of the oral cavity (HP:0100649)3.41581761
44Rhabdomyosarcoma (HP:0002859)3.35316709
45Rib fusion (HP:0000902)3.34488707
46Agnosia (HP:0010524)3.26528389
47Intestinal fistula (HP:0100819)3.26513169
48Preaxial foot polydactyly (HP:0001841)3.23561314
49Abnormality of the phalanges of the 5th finger (HP:0004213)3.15610630
50Abnormality of the aortic arch (HP:0012303)3.15324383
51Stenosis of the external auditory canal (HP:0000402)3.14678405
52Vaginal fistula (HP:0004320)3.14446288
53Asplenia (HP:0001746)3.08692393
54Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.07239440
55Myelomeningocele (HP:0002475)3.03919542
56Glioma (HP:0009733)3.01392295
57Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.01262170
58Skin pits (HP:0100276)2.98299308
59Neoplasm of striated muscle (HP:0009728)2.95037896
60Patellar aplasia (HP:0006443)2.91139626
61Esophageal atresia (HP:0002032)2.89387471
62Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.88480214
63Fused cervical vertebrae (HP:0002949)2.84662199
64Chromosomal breakage induced by crosslinking agents (HP:0003221)2.83087194
65Missing ribs (HP:0000921)2.82595472
66Aplasia/Hypoplasia of the spleen (HP:0010451)2.82533952
67Abnormal number of incisors (HP:0011064)2.81238854
68Absent thumb (HP:0009777)2.80247264
69Reticulocytopenia (HP:0001896)2.77611526
70Aplasia/Hypoplasia of the patella (HP:0006498)2.73430919
71Gonadal dysgenesis (HP:0000133)2.73343728
72Chromsome breakage (HP:0040012)2.72816182
73Renal duplication (HP:0000075)2.71509281
74Concave nail (HP:0001598)2.66581066
75Dislocated radial head (HP:0003083)2.66273834
76Absent eyebrow (HP:0002223)2.58207855
77Sex reversal (HP:0012245)2.53737715
78Abnormal sex determination (HP:0012244)2.53737715
79Abnormality of the radial head (HP:0003995)2.52281813
80Hepatoblastoma (HP:0002884)2.52157214
81Ectopic anus (HP:0004397)2.50502313
82Supernumerary bones of the axial skeleton (HP:0009144)2.49526148
83Mesomelia (HP:0003027)2.47961980
84Supernumerary ribs (HP:0005815)2.47580350
85Oral leukoplakia (HP:0002745)2.47175250
86Aplasia/Hypoplasia of the scapulae (HP:0006713)2.46716567
87Hypoplastic scapulae (HP:0000882)2.46716567
88Anal stenosis (HP:0002025)2.44223725
89Impulsivity (HP:0100710)2.43658873
90Vertebral fusion (HP:0002948)2.43401953
91Abnormality of the labia (HP:0000058)2.40059351
92Hypoplastic nipples (HP:0002557)2.38487509
93Short 1st metacarpal (HP:0010034)2.35854510
94Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.35854510
95Ureteral duplication (HP:0000073)2.35270868
96Basal cell carcinoma (HP:0002671)2.34151603
97Abnormality of the umbilical cord (HP:0010881)2.32482107
98Brittle hair (HP:0002299)2.32427614
99Abnormality of the salivary glands (HP:0010286)2.31780998
100Short 5th finger (HP:0009237)2.30648409
101Abnormality of cochlea (HP:0000375)2.28438985
102Horseshoe kidney (HP:0000085)2.28104742
103Thickened helices (HP:0000391)2.27939020
104Small epiphyses (HP:0010585)2.27728852
105Aqueductal stenosis (HP:0002410)2.27619351
106Short phalanx of the thumb (HP:0009660)2.27572770
107Abnormal lung lobation (HP:0002101)2.23837172
108Diastasis recti (HP:0001540)2.21967130
109Split foot (HP:0001839)2.18766413
110Irregular epiphyses (HP:0010582)2.18401045
111Patent foramen ovale (HP:0001655)2.17417088
112Gastrointestinal atresia (HP:0002589)2.16279759
113Cerebral hypomyelination (HP:0006808)2.15773173
114Hydroureter (HP:0000072)2.15049704
115Abnormality of the phalanges of the 2nd finger (HP:0009541)2.14587955
116Deviation of the thumb (HP:0009603)2.14581585
117Dysphonia (HP:0001618)2.14564520
118Proximal placement of thumb (HP:0009623)2.12882396
119Trismus (HP:0000211)2.10921874
120Pseudobulbar signs (HP:0002200)2.10013221
121Meckel diverticulum (HP:0002245)2.09284420
122Ankyloglossia (HP:0010296)2.08447180
123Intestinal atresia (HP:0011100)2.08109702
124Thoracolumbar scoliosis (HP:0002944)2.07665690
125Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.07634477
126Septo-optic dysplasia (HP:0100842)2.07218737
127Chin dimple (HP:0010751)2.06993942
128Absent toe (HP:0010760)2.06804381
129Abnormality of the 1st metacarpal (HP:0010009)2.05261801
130Tracheoesophageal fistula (HP:0002575)2.05100746
131Lower limb asymmetry (HP:0100559)2.04781665
132Shawl scrotum (HP:0000049)2.04589066
133Abnormality of the ileum (HP:0001549)2.03585808
134Abnormality of pyrimidine metabolism (HP:0004353)2.03526250
135Anophthalmia (HP:0000528)2.03144866
136Hemivertebrae (HP:0002937)2.02540140
137Anteriorly placed anus (HP:0001545)2.02215875
138Neoplasm of the pancreas (HP:0002894)2.01018480
139Biliary tract neoplasm (HP:0100574)2.00758924
140Short thumb (HP:0009778)2.00598027
141Omphalocele (HP:0001539)2.00301278
142Choroideremia (HP:0001139)1.99156082
143Hydronephrosis (HP:0000126)1.99027793
144High anterior hairline (HP:0009890)1.98771809
145Abnormality of the anterior horn cell (HP:0006802)1.98259586
146Degeneration of anterior horn cells (HP:0002398)1.98259586
147Rough bone trabeculation (HP:0100670)1.96449546
148Ectopic kidney (HP:0000086)1.96175329
149Long palpebral fissure (HP:0000637)1.95689748
150Amaurosis fugax (HP:0100576)1.95133615
151Ovarian neoplasm (HP:0100615)1.93066678
152Vitreoretinal degeneration (HP:0000655)1.92880342
153Soft skin (HP:0000977)1.92459594
154Atresia of the external auditory canal (HP:0000413)1.91901322
155Abnormality of the right ventricle (HP:0001707)1.91619341
156* Breast aplasia (HP:0100783)1.91500534
157Neurofibrillary tangles (HP:0002185)1.90758454
158Aplasia/Hypoplasia of the sternum (HP:0006714)1.90583681
159Abnormality of the humeroradial joint (HP:0100744)1.89606126
160Cutaneous finger syndactyly (HP:0010554)1.89065385
161Oligodontia (HP:0000677)1.88855503
162Bifid scrotum (HP:0000048)1.87986537
163Skull defect (HP:0001362)1.87369844
164Anal atresia (HP:0002023)1.86195637
165Maternal diabetes (HP:0009800)1.84854211
166Duplicated collecting system (HP:0000081)1.84447693
167Malignant gastrointestinal tract tumors (HP:0006749)1.83940234
168Gastrointestinal carcinoma (HP:0002672)1.83940234
169Adenoma sebaceum (HP:0009720)1.83587295
170Angiofibromas (HP:0010615)1.83587295
171Hypoplasia of the radius (HP:0002984)1.82751761
172Abnormality of the parathyroid morphology (HP:0011766)1.82458289
173Aplasia/Hypoplasia of the uvula (HP:0010293)1.82425614
174Premature skin wrinkling (HP:0100678)1.81310577
175Deep palmar crease (HP:0006191)1.81264356
176Split hand (HP:0001171)1.80755077
177Triphalangeal thumb (HP:0001199)1.80650842
178Aplasia/Hypoplasia involving the musculature (HP:0001460)1.80500123
179Facial hemangioma (HP:0000329)1.80068588
18011 pairs of ribs (HP:0000878)1.79720339
181Synostosis of carpal bones (HP:0005048)1.78474362
182Cutaneous syndactyly (HP:0012725)1.78197655
183Morphological abnormality of the inner ear (HP:0011390)1.76853284

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.99932683
2BUB14.60370181
3CDK123.77006174
4MKNK23.54333971
5EPHA23.54269150
6CDC73.47295589
7WEE13.46225905
8NTRK33.36747044
9ARAF3.09722481
10TTK2.74719206
11MKNK12.62886542
12DAPK22.58869029
13SRPK12.56633607
14TSSK62.45709745
15NEK12.30273626
16RPS6KB22.30016191
17MARK22.00383781
18TESK21.99898910
19PLK21.98224989
20CDK71.97715761
21BRD41.97352062
22NEK21.91182961
23PAK61.79363674
24LATS21.79267407
25MARK11.77827102
26PLK11.76075680
27PASK1.75810393
28PNCK1.73239908
29PRKD31.63313345
30MAP3K41.63045581
31TLK11.59875497
32EIF2AK11.57720800
33ALK1.54380364
34CASK1.51319600
35ATR1.49471423
36PLK31.48152057
37MAP2K71.48150513
38BMPR1B1.47909904
39NTRK11.47884350
40CHEK21.42064686
41CHEK11.41081728
42MAP3K81.39938214
43PLK41.33036666
44AURKA1.32896251
45STK111.32287348
46TIE11.32136287
47PAK41.31657868
48MAP3K131.28081829
49MET1.25884817
50NTRK21.24767783
51BRSK21.24730946
52AURKB1.23915265
53FLT31.20459509
54CDK181.18843260
55CDK151.18107534
56CDK41.17836418
57DAPK31.16574818
58TNIK1.15319750
59MINK11.15058212
60VRK11.13888241
61FGFR21.11312773
62UHMK11.11167627
63TRIM281.04730367
64CDK21.04686461
65SCYL21.04330810
66DYRK21.01897991
67ATM1.01409970
68CDK190.99550016
69ICK0.98747621
70MAPK130.98018404
71STK38L0.94706461
72AKT30.94671140
73DYRK30.93478979
74ROCK10.93430283
75KSR20.91848279
76STK100.91594577
77WNK30.91384615
78TESK10.89024203
79CSNK1E0.88422475
80STK40.88408711
81MAP3K100.87418939
82CDK60.87032733
83CAMK10.86925679
84MAPKAPK30.85695883
85PRKCI0.82925461
86MTOR0.82748514
87STK160.82275403
88CSNK2A20.80797027
89PKN20.80651653
90NME20.78380823
91EEF2K0.78334469
92EIF2AK30.78051144
93CDK10.76037204
94CSNK1D0.72724870
95DMPK0.72627170
96PRKCG0.71632384
97PAK10.68358595
98CAMKK10.68144183
99DYRK1A0.68122129
100CDK50.68045890
101MAP4K20.67826794
102RIPK10.67025562
103BMX0.66425129
104CSNK1A1L0.66411452
105CSNK1G30.65592275
106AKT20.64146990
107BRSK10.62863258
108ROCK20.61773421
109RAF10.60878771
110CSNK2A10.57882023
111BCKDK0.57567018
112PRKDC0.55902259
113CAMK2B0.55708528
114ACVR1B0.55670161
115PDGFRA0.54798500
116MOS0.54376421
117NEK60.53533028
118TNK20.53391772
119CAMK2A0.51870561
120MAP3K90.51696137
121KSR10.50618595
122PAK30.49545038
123MATK0.49195526
124FGFR10.48036335
125TGFBR10.47896360
126CSNK1G10.45890127
127PIM10.45323315
128PAK20.45119230
129VRK20.44809437
130SGK2230.43909999
131SGK4940.43909999
132GRK10.42741367
133LATS10.42045857
134MAPK140.40781432
135ZAK0.40673473
136ERBB40.39983148
137CSNK1G20.39596150
138LIMK10.38800670
139GSK3B0.38608656
140DAPK10.37722571
141CLK10.37708615
142PINK10.36417136
143PDK20.34066675
144GRK50.33643606
145ADRBK10.33593642
146GRK60.33096089
147BCR0.33015755
148MELK0.31183161
149TTN0.31097010
150MAPK10.30885926
151MAPK100.30452213
152CAMK2G0.29887614
153TYRO30.29779640
154SRC0.29187681
155MAPK90.29005794
156CDK11A0.28827994
157ERBB20.27844606
158CDK30.27418219
159AKT10.25627543
160BRAF0.25388650
161RPS6KA50.24870963
162PBK0.24703904
163CDK140.24694133

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.95105933
2DNA replication_Homo sapiens_hsa030304.86798346
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.19472319
4Spliceosome_Homo sapiens_hsa030403.71203250
5RNA transport_Homo sapiens_hsa030133.57624607
6One carbon pool by folate_Homo sapiens_hsa006703.49401260
7Steroid biosynthesis_Homo sapiens_hsa001003.25463344
8RNA polymerase_Homo sapiens_hsa030203.22384214
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.15795651
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.97961478
11Ribosome_Homo sapiens_hsa030102.97087773
12Nucleotide excision repair_Homo sapiens_hsa034202.81369564
13Base excision repair_Homo sapiens_hsa034102.69392032
14Homologous recombination_Homo sapiens_hsa034402.67667624
15Nicotine addiction_Homo sapiens_hsa050332.45732718
16Cell cycle_Homo sapiens_hsa041102.44029541
17Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.23757692
18Pyrimidine metabolism_Homo sapiens_hsa002402.16209924
19mRNA surveillance pathway_Homo sapiens_hsa030152.06606791
20Fanconi anemia pathway_Homo sapiens_hsa034602.00927668
21RNA degradation_Homo sapiens_hsa030181.95129380
22Proteasome_Homo sapiens_hsa030501.94014703
23Synaptic vesicle cycle_Homo sapiens_hsa047211.77995139
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.63853299
25Basal cell carcinoma_Homo sapiens_hsa052171.59691440
26p53 signaling pathway_Homo sapiens_hsa041151.57891182
27Gastric acid secretion_Homo sapiens_hsa049711.57410823
28Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.54809542
29Axon guidance_Homo sapiens_hsa043601.54005224
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.53360257
31Non-homologous end-joining_Homo sapiens_hsa034501.50458817
32Biosynthesis of amino acids_Homo sapiens_hsa012301.47696908
33Basal transcription factors_Homo sapiens_hsa030221.46502709
34GABAergic synapse_Homo sapiens_hsa047271.40305643
35Fatty acid metabolism_Homo sapiens_hsa012121.39945730
36Retinol metabolism_Homo sapiens_hsa008301.38627282
37Systemic lupus erythematosus_Homo sapiens_hsa053221.35260858
38Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.30892480
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.27275949
40Hedgehog signaling pathway_Homo sapiens_hsa043401.27060524
41Hippo signaling pathway_Homo sapiens_hsa043901.23654927
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.17608380
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.14275585
44Circadian entrainment_Homo sapiens_hsa047131.13119094
45Oocyte meiosis_Homo sapiens_hsa041141.12563691
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.12280443
47Purine metabolism_Homo sapiens_hsa002301.11276661
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.11247619
49Insulin secretion_Homo sapiens_hsa049111.09711925
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.09141787
51Protein digestion and absorption_Homo sapiens_hsa049741.08856645
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08698537
53Glutamatergic synapse_Homo sapiens_hsa047241.08425017
54Selenocompound metabolism_Homo sapiens_hsa004501.03993400
55Long-term potentiation_Homo sapiens_hsa047201.03633783
56cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03602835
57Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.02758553
58Morphine addiction_Homo sapiens_hsa050321.00726778
59Propanoate metabolism_Homo sapiens_hsa006401.00409124
60Calcium signaling pathway_Homo sapiens_hsa040200.99661458
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.96590761
62Dopaminergic synapse_Homo sapiens_hsa047280.96435880
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.95158405
64TGF-beta signaling pathway_Homo sapiens_hsa043500.90203279
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90066596
66Epstein-Barr virus infection_Homo sapiens_hsa051690.89401779
67Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85981429
68Amphetamine addiction_Homo sapiens_hsa050310.83415190
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82640064
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81958127
71Viral carcinogenesis_Homo sapiens_hsa052030.81776468
72MicroRNAs in cancer_Homo sapiens_hsa052060.79565560
73Olfactory transduction_Homo sapiens_hsa047400.79222199
74Thyroid cancer_Homo sapiens_hsa052160.79051703
75cAMP signaling pathway_Homo sapiens_hsa040240.77479773
76Cocaine addiction_Homo sapiens_hsa050300.76386080
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72909146
78Nitrogen metabolism_Homo sapiens_hsa009100.72547423
79beta-Alanine metabolism_Homo sapiens_hsa004100.71759327
80Notch signaling pathway_Homo sapiens_hsa043300.70740774
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.70689550
82ECM-receptor interaction_Homo sapiens_hsa045120.70262961
83Arginine and proline metabolism_Homo sapiens_hsa003300.70253512
84Folate biosynthesis_Homo sapiens_hsa007900.69500874
85* Rap1 signaling pathway_Homo sapiens_hsa040150.69418524
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68867541
87Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67600835
88Tight junction_Homo sapiens_hsa045300.67427046
89Wnt signaling pathway_Homo sapiens_hsa043100.66012180
90Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65873498
91Carbon metabolism_Homo sapiens_hsa012000.64866113
92HTLV-I infection_Homo sapiens_hsa051660.63198116
93Adherens junction_Homo sapiens_hsa045200.62171972
94Fatty acid elongation_Homo sapiens_hsa000620.62026087
95Oxytocin signaling pathway_Homo sapiens_hsa049210.60812613
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59295428
97Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58201549
98Alcoholism_Homo sapiens_hsa050340.57363480
99ErbB signaling pathway_Homo sapiens_hsa040120.56817576
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.56278468
101Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55804277
102Fatty acid degradation_Homo sapiens_hsa000710.55769537
103Cholinergic synapse_Homo sapiens_hsa047250.55357089
104Butanoate metabolism_Homo sapiens_hsa006500.51087207
105Glutathione metabolism_Homo sapiens_hsa004800.51048165
106Thyroid hormone synthesis_Homo sapiens_hsa049180.49921811
107Phototransduction_Homo sapiens_hsa047440.48507709
108Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47780355
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46527404
110Bladder cancer_Homo sapiens_hsa052190.46435372
111Gap junction_Homo sapiens_hsa045400.44167655
112Herpes simplex infection_Homo sapiens_hsa051680.43351407
113Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43199831
114Lysine degradation_Homo sapiens_hsa003100.42896595
115mTOR signaling pathway_Homo sapiens_hsa041500.42624622
116* Pathways in cancer_Homo sapiens_hsa052000.41858002
117Inositol phosphate metabolism_Homo sapiens_hsa005620.40734511
118Glioma_Homo sapiens_hsa052140.39804572
119Fructose and mannose metabolism_Homo sapiens_hsa000510.38578262
120Colorectal cancer_Homo sapiens_hsa052100.37148016
121* Ras signaling pathway_Homo sapiens_hsa040140.36634918
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36554578
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36534245
124Pentose phosphate pathway_Homo sapiens_hsa000300.35726603
125Taste transduction_Homo sapiens_hsa047420.35633243
126Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.34634778
127Huntingtons disease_Homo sapiens_hsa050160.33929717
128Sulfur relay system_Homo sapiens_hsa041220.32849670
129Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32054376
130Serotonergic synapse_Homo sapiens_hsa047260.31966522
131Fat digestion and absorption_Homo sapiens_hsa049750.31567773
132HIF-1 signaling pathway_Homo sapiens_hsa040660.29939817
133Bile secretion_Homo sapiens_hsa049760.29550711
134Salivary secretion_Homo sapiens_hsa049700.29280101
135Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.29271747
136Maturity onset diabetes of the young_Homo sapiens_hsa049500.27929336
137Peroxisome_Homo sapiens_hsa041460.27907710
138* Melanoma_Homo sapiens_hsa052180.25075058
139Small cell lung cancer_Homo sapiens_hsa052220.21890608
140Antigen processing and presentation_Homo sapiens_hsa046120.20392526
141Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.19500699
142Melanogenesis_Homo sapiens_hsa049160.19209518
143Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.16227192
144Phenylalanine metabolism_Homo sapiens_hsa003600.14625342
145Proteoglycans in cancer_Homo sapiens_hsa052050.14399949
146Galactose metabolism_Homo sapiens_hsa000520.12392458
147Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.11150649
148* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.11017441
149Metabolic pathways_Homo sapiens_hsa011000.10936223
150Linoleic acid metabolism_Homo sapiens_hsa005910.10491363
151Tyrosine metabolism_Homo sapiens_hsa003500.09072382
152* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.08713694
153Prion diseases_Homo sapiens_hsa050200.08506832
154Arginine biosynthesis_Homo sapiens_hsa002200.08443258
155Arachidonic acid metabolism_Homo sapiens_hsa005900.07796473
156Pyruvate metabolism_Homo sapiens_hsa006200.04216600
157Thyroid hormone signaling pathway_Homo sapiens_hsa049190.03556413
158Prostate cancer_Homo sapiens_hsa052150.03132465
159Apoptosis_Homo sapiens_hsa042100.00418692
160Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.00207723
161Glucagon signaling pathway_Homo sapiens_hsa04922-0.0116626
162Vitamin B6 metabolism_Homo sapiens_hsa00750-0.0110792
163Legionellosis_Homo sapiens_hsa05134-0.0010740

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