FGF18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)7.27710786
2endocardial cushion morphogenesis (GO:0003203)6.19553744
3cell proliferation in forebrain (GO:0021846)5.72156009
4proline biosynthetic process (GO:0006561)5.59405331
5atrioventricular valve morphogenesis (GO:0003181)5.35927444
6regulation of glucocorticoid metabolic process (GO:0031943)5.29663728
7regulation of glomerulus development (GO:0090192)5.14196427
8G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.89330522
9negative regulation of hormone metabolic process (GO:0032351)4.84293047
10negative regulation of hormone biosynthetic process (GO:0032353)4.84293047
11regulation of Wnt signaling pathway involved in heart development (GO:0003307)4.77836700
12positive regulation of odontogenesis (GO:0042482)4.69312036
13establishment of apical/basal cell polarity (GO:0035089)4.67784519
14mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.67155300
15sulfation (GO:0051923)4.64488118
16regulation of cell proliferation involved in kidney development (GO:1901722)4.64399542
17mesenchyme morphogenesis (GO:0072132)4.63796622
18establishment of monopolar cell polarity (GO:0061162)4.59482793
19establishment or maintenance of monopolar cell polarity (GO:0061339)4.59482793
20positive regulation of osteoblast proliferation (GO:0033690)4.58255822
21negative regulation of chondrocyte differentiation (GO:0032331)4.43191846
22regulation of DNA endoreduplication (GO:0032875)4.41313914
23behavioral response to nicotine (GO:0035095)4.25747651
24skin morphogenesis (GO:0043589)4.16935568
25proline metabolic process (GO:0006560)4.11675665
26mesonephros development (GO:0001823)4.10386858
27planar cell polarity pathway involved in neural tube closure (GO:0090179)4.08835837
28establishment of protein localization to mitochondrial membrane (GO:0090151)4.07976090
29regulation of chromatin binding (GO:0035561)4.07146432
30regulation of phospholipid biosynthetic process (GO:0071071)4.05863686
31positive regulation of metanephros development (GO:0072216)4.04007663
32mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.03923608
33lateral sprouting from an epithelium (GO:0060601)4.00836663
34chaperone-mediated protein transport (GO:0072321)3.99199631
35dorsal/ventral axis specification (GO:0009950)3.91223421
36regulation of male gonad development (GO:2000018)3.90879855
37regulation of posttranscriptional gene silencing (GO:0060147)3.90732107
38regulation of gene silencing by miRNA (GO:0060964)3.90732107
39regulation of gene silencing by RNA (GO:0060966)3.90732107
40mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.82585243
41mitochondrial respiratory chain complex I assembly (GO:0032981)3.82585243
42NADH dehydrogenase complex assembly (GO:0010257)3.82585243
43negative regulation of cartilage development (GO:0061037)3.80738130
44regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.76934275
45energy coupled proton transport, down electrochemical gradient (GO:0015985)3.76379654
46ATP synthesis coupled proton transport (GO:0015986)3.76379654
47heart valve morphogenesis (GO:0003179)3.72775609
48neural crest cell development (GO:0014032)3.71713102
49positive regulation of astrocyte differentiation (GO:0048711)3.71693329
50positive regulation of cAMP-mediated signaling (GO:0043950)3.70168368
51respiratory electron transport chain (GO:0022904)3.67953498
52anatomical structure regression (GO:0060033)3.66431979
53regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.63875772
54electron transport chain (GO:0022900)3.63157333
55protein complex biogenesis (GO:0070271)3.61909760
56pharyngeal system development (GO:0060037)3.59900801
57embryonic camera-type eye development (GO:0031076)3.59020157
58adult heart development (GO:0007512)3.58487533
59regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.57489451
60pathway-restricted SMAD protein phosphorylation (GO:0060389)3.57050748
61negative regulation of catenin import into nucleus (GO:0035414)3.56290952
62hair cell differentiation (GO:0035315)3.56209165
63non-canonical Wnt signaling pathway (GO:0035567)3.54629249
64embryonic process involved in female pregnancy (GO:0060136)3.54298000
65regulation of glomerular filtration (GO:0003093)3.54083010
66notochord development (GO:0030903)3.52619522
67cell surface receptor signaling pathway involved in heart development (GO:0061311)3.52049820
68epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.49289307
69convergent extension (GO:0060026)3.46504469
70bone morphogenesis (GO:0060349)3.43593546
71positive regulation of p38MAPK cascade (GO:1900745)3.43496027
72mitochondrial respiratory chain complex assembly (GO:0033108)3.43243016
73regulation of steroid hormone biosynthetic process (GO:0090030)3.42761691
74mesenchymal cell proliferation (GO:0010463)3.39651644
75positive regulation of cardiac muscle cell differentiation (GO:2000727)3.38244524
76proximal/distal pattern formation (GO:0009954)3.37151213
77Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.34427037
78negative regulation of systemic arterial blood pressure (GO:0003085)3.33486899
79positive regulation of digestive system process (GO:0060456)3.33406057
80bundle of His cell to Purkinje myocyte communication (GO:0086069)3.33142533
81transcription from mitochondrial promoter (GO:0006390)3.32792518
82replication fork processing (GO:0031297)3.32617195
83protein heterotrimerization (GO:0070208)3.29856143
84regulation of metanephros development (GO:0072215)3.25210564
85membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.25124258
86response to UV-C (GO:0010225)3.23130117
87positive regulation of male gonad development (GO:2000020)3.21770539
88embryonic hindlimb morphogenesis (GO:0035116)3.20082623
89urogenital system development (GO:0001655)3.18942544
90ribosomal small subunit biogenesis (GO:0042274)3.17881246
91cellular response to ATP (GO:0071318)3.17014895
92fat-soluble vitamin catabolic process (GO:0042363)3.17002574
93vitamin catabolic process (GO:0009111)3.17002574
94cell proliferation involved in kidney development (GO:0072111)3.14950169
95viral transcription (GO:0019083)3.13458352
96regulation of integrin activation (GO:0033623)3.12119456
97* chondrocyte development (GO:0002063)3.12031215
98glomerular filtration (GO:0003094)3.11685262
99somite development (GO:0061053)3.11674766
100regulation of establishment of planar polarity (GO:0090175)3.10295207
101negative regulation of metanephros development (GO:0072217)3.08611839
102branching involved in salivary gland morphogenesis (GO:0060445)3.07434052
103adrenergic receptor signaling pathway (GO:0071875)3.06715020
104negative regulation of axon extension involved in axon guidance (GO:0048843)3.06217594
105regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.05865984
106water-soluble vitamin biosynthetic process (GO:0042364)3.03996075
107regulation of tight junction assembly (GO:2000810)3.03026067
108ribosomal small subunit assembly (GO:0000028)3.02521515
109transmission of nerve impulse (GO:0019226)3.01922651
110negative regulation of cardiac muscle tissue development (GO:0055026)2.99180048
111positive regulation of protein homooligomerization (GO:0032464)2.99064086
112cardiac epithelial to mesenchymal transition (GO:0060317)2.97963559
113epithelial to mesenchymal transition (GO:0001837)2.97857231
114collagen fibril organization (GO:0030199)2.95878128
115mesenchymal cell development (GO:0014031)2.95744348
116regulation of hippo signaling (GO:0035330)2.94938612
117negative regulation of heart rate (GO:0010459)2.94826347
118limb bud formation (GO:0060174)2.94449104
119retinoic acid receptor signaling pathway (GO:0048384)2.92325732
120cochlea morphogenesis (GO:0090103)2.91877346
121glial cell migration (GO:0008347)2.89930816
122chromatin remodeling at centromere (GO:0031055)2.89073608
123renal filtration (GO:0097205)2.88435231
124metanephric mesenchyme development (GO:0072075)2.87709411
125regulation of actin filament-based movement (GO:1903115)2.87240751
126positive regulation of myotube differentiation (GO:0010831)2.86397579
127negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.86233250
128N-acetylglucosamine metabolic process (GO:0006044)2.85972770
129negative regulation of Ras GTPase activity (GO:0034261)2.84212542
130regulation of p38MAPK cascade (GO:1900744)2.83666675
131cell migration involved in gastrulation (GO:0042074)2.82565634
132parturition (GO:0007567)2.82481480
133pericardium development (GO:0060039)2.82281186
134nephron tubule formation (GO:0072079)2.81896789
135cell migration in hindbrain (GO:0021535)2.81565268
136renal system process involved in regulation of blood volume (GO:0001977)2.81124598
137lung morphogenesis (GO:0060425)2.79285289
138plasma membrane repair (GO:0001778)2.79028712
139organ induction (GO:0001759)2.78606004
140negative regulation of gene silencing (GO:0060969)2.76363959
141cardiac right ventricle morphogenesis (GO:0003215)2.75773304
142translational termination (GO:0006415)2.75178878
143oxidative demethylation (GO:0070989)2.74943857
144negative regulation of appetite (GO:0032099)2.73410994
145negative regulation of response to food (GO:0032096)2.73410994
146* regulation of cartilage development (GO:0061035)2.72500210
147mesenchymal to epithelial transition (GO:0060231)2.72304966
148regulation of mesoderm development (GO:2000380)2.72202188
149regulation of cardiac muscle cell contraction (GO:0086004)2.71942030
150negative regulation of glial cell proliferation (GO:0060253)2.71602748
151hindlimb morphogenesis (GO:0035137)2.71417519
152CENP-A containing nucleosome assembly (GO:0034080)2.71272222
153negative regulation of cell cycle arrest (GO:0071157)2.71048229
154outer ear morphogenesis (GO:0042473)2.69479380
155positive regulation of fatty acid beta-oxidation (GO:0032000)2.69282448
156response to inactivity (GO:0014854)2.68763539
157negative regulation of transcription regulatory region DNA binding (GO:2000678)2.68071401
158regulation of cAMP-dependent protein kinase activity (GO:2000479)2.68045834
159G1 DNA damage checkpoint (GO:0044783)2.67800195
160histone exchange (GO:0043486)2.67776871
161regulation of cardiac muscle cell differentiation (GO:2000725)2.67575138
162cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.67195046
163adrenal gland development (GO:0030325)2.64827044
164spinal cord development (GO:0021510)2.64796089
165termination of RNA polymerase III transcription (GO:0006386)2.63919156
166transcription elongation from RNA polymerase III promoter (GO:0006385)2.63919156
167maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.63430795
168regulation of heart morphogenesis (GO:2000826)2.63193025
169otic vesicle formation (GO:0030916)2.62758861
170negative regulation of kidney development (GO:0090185)2.62686663
171neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.62339169
172regulation of organ formation (GO:0003156)2.61897406
173kidney mesenchyme development (GO:0072074)2.61599317
174positive regulation of stem cell differentiation (GO:2000738)2.61432355
175establishment of planar polarity (GO:0001736)2.61174545
176establishment of tissue polarity (GO:0007164)2.61174545
177regulation of mitochondrial translation (GO:0070129)2.60675828
178thyroid gland development (GO:0030878)2.60120864
179regulation of apoptotic process involved in morphogenesis (GO:1902337)2.58966714
180tooth mineralization (GO:0034505)2.58582622
181renal system development (GO:0072001)2.58550382
182regulation of collateral sprouting (GO:0048670)2.58384788
183negative regulation of axon guidance (GO:1902668)2.58041200
184negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.57494806
185anterior/posterior axis specification, embryo (GO:0008595)2.57238071
186regulation of cardiac muscle tissue development (GO:0055024)2.57215380
187trophoblast giant cell differentiation (GO:0060707)2.56137225
188regulation of protein homooligomerization (GO:0032462)2.55456710
189aorta morphogenesis (GO:0035909)2.54904200
190* positive regulation of cartilage development (GO:0061036)2.53389055
191substrate-independent telencephalic tangential migration (GO:0021826)2.50503539
192substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.50503539
193signal complex assembly (GO:0007172)2.46437570
194mesenchymal cell differentiation (GO:0048762)2.44448949
195germ cell migration (GO:0008354)2.42912606

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.81554429
2STAT6_21828071_ChIP-Seq_BEAS2B_Human4.62348684
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.50595383
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.78698952
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.52770336
6AR_21572438_ChIP-Seq_LNCaP_Human2.96186037
7ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.77304951
8SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.67924704
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.55267089
10ERG_21242973_ChIP-ChIP_JURKAT_Human2.46621878
11POU5F1_16153702_ChIP-ChIP_HESCs_Human2.46461757
12TP53_20018659_ChIP-ChIP_R1E_Mouse2.42885259
13KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.35220728
14KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.35220728
15KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.35220728
16IGF1R_20145208_ChIP-Seq_DFB_Human2.23004606
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.21389088
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.15029934
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.07300908
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.06321992
21NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.05118892
22EST1_17652178_ChIP-ChIP_JURKAT_Human1.97149619
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.93530714
24EZH2_27304074_Chip-Seq_ESCs_Mouse1.91458164
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.88216783
26NANOG_16153702_ChIP-ChIP_HESCs_Human1.88135542
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.88027223
28SOX9_24532713_ChIP-Seq_HFSC_Mouse1.87278363
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.83757671
30SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.81990830
31* RING1B_27294783_Chip-Seq_NPCs_Mouse1.78698206
32RNF2_18974828_ChIP-Seq_MESCs_Mouse1.78692497
33EZH2_18974828_ChIP-Seq_MESCs_Mouse1.78692497
34RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78012365
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.76642306
36* EWS_26573619_Chip-Seq_HEK293_Human1.75483326
37JARID2_20064375_ChIP-Seq_MESCs_Mouse1.72070337
38VDR_22108803_ChIP-Seq_LS180_Human1.71819717
39PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.70437668
40MYC_18940864_ChIP-ChIP_HL60_Human1.70018931
41SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.66670376
42RNF2_27304074_Chip-Seq_ESCs_Mouse1.64471577
43SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.64307588
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.61386798
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.59691836
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59667925
47KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.59316815
48SOX2_16153702_ChIP-ChIP_HESCs_Human1.57563527
49SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.54884894
50PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.54632328
51* ESR1_21235772_ChIP-Seq_MCF-7_Human1.53382188
52POU5F1_16518401_ChIP-PET_MESCs_Mouse1.52468459
53LXR_22292898_ChIP-Seq_THP-1_Human1.50929927
54* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.50248548
55TCF3_18692474_ChIP-Seq_MEFs_Mouse1.50135600
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49984455
57* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.48709599
58FUS_26573619_Chip-Seq_HEK293_Human1.48157568
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46871116
60TCF3_18692474_ChIP-Seq_MESCs_Mouse1.46374162
61KDM2B_26808549_Chip-Seq_K562_Human1.43096690
62EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.42409614
63CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.40891990
64MYC_18555785_ChIP-Seq_MESCs_Mouse1.39982171
65RACK7_27058665_Chip-Seq_MCF-7_Human1.39336422
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.38458372
67HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.37515381
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35171353
69* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.34939864
70SOX2_18555785_ChIP-Seq_MESCs_Mouse1.33038351
71* RING1B_27294783_Chip-Seq_ESCs_Mouse1.32883857
72* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.32108695
73* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.31892423
74* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.31636482
75CTCF_27219007_Chip-Seq_Bcells_Human1.29011493
76ETS1_20019798_ChIP-Seq_JURKAT_Human1.27792156
77TDRD3_21172665_ChIP-Seq_MCF-7_Human1.27684106
78* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.26554403
79* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25397305
80* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.25165083
81ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.24473726
82ELK1_19687146_ChIP-ChIP_HELA_Human1.24368837
83RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.23269629
84* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.23020806
85TP63_19390658_ChIP-ChIP_HaCaT_Human1.21514342
86UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21373141
87SALL1_21062744_ChIP-ChIP_HESCs_Human1.21184390
88ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20519405
89* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.18870536
90* EZH2_27294783_Chip-Seq_ESCs_Mouse1.18055901
91ESR1_15608294_ChIP-ChIP_MCF-7_Human1.17568506
92LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17248964
93KDM2B_26808549_Chip-Seq_SUP-B15_Human1.15549085
94NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.15434508
95JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.13906556
96RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13501436
97ZNF263_19887448_ChIP-Seq_K562_Human1.12215011
98TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.11393104
99NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.11344970
100P300_19829295_ChIP-Seq_ESCs_Human1.10672569
101CJUN_26792858_Chip-Seq_BT549_Human1.10373810
102AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08461357
103* TP53_23651856_ChIP-Seq_MEFs_Mouse1.07496406
104RUNX1_27514584_Chip-Seq_MCF-7_Human1.07292747
105KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06654303
106EZH2_22144423_ChIP-Seq_EOC_Human1.06476942
107ISL1_27105846_Chip-Seq_CPCs_Mouse1.05774098
108* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.05453243
109POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05114217
110ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04409574
111* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02451541
112TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.02283339
113STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01699465
114PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00511002
115SMAD3_21741376_ChIP-Seq_HESCs_Human1.00366385
116P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99925866
117CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99761850
118PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98997974
119GATA1_26923725_Chip-Seq_HPCs_Mouse0.98368547
120P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98348085
121ZNF274_21170338_ChIP-Seq_K562_Hela0.98200432
122NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.97686532
123CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97205760
124CDX2_20551321_ChIP-Seq_CACO-2_Human0.97189468
125CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96694614
126* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96488552
127POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.96095428
128EP300_21415370_ChIP-Seq_HL-1_Mouse0.94722818
129CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93915568
130* RNF2_27304074_Chip-Seq_NSC_Mouse0.93684699
131AHR_22903824_ChIP-Seq_MCF-7_Human0.92925964
132WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92088783
133FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92031358
134TTF2_22483619_ChIP-Seq_HELA_Human0.90978601
135RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.90328042
136TBX3_20139965_ChIP-Seq_ESCs_Mouse0.89282415
137* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.89032824
138SA1_27219007_Chip-Seq_ERYTHROID_Human0.88925871
139CBX2_27304074_Chip-Seq_ESCs_Mouse0.88916205
140TET1_21490601_ChIP-Seq_MESCs_Mouse0.88573941
141TBX3_20139965_ChIP-Seq_MESCs_Mouse0.88360773
142OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.87982636
143IRF1_19129219_ChIP-ChIP_H3396_Human0.87644426
144STAT3_1855785_ChIP-Seq_MESCs_Mouse0.86542014
145* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.86018259
146* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.85837246
147TAF15_26573619_Chip-Seq_HEK293_Human0.84340524
148GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84246088
149PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.82937033
150UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.82603548
151* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.82371600
152* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.81446988
153HOXB7_26014856_ChIP-Seq_BT474_Human0.81134656
154BCAT_22108803_ChIP-Seq_LS180_Human0.80458488
155ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.80242238
156SMAD3_21741376_ChIP-Seq_EPCs_Human0.79690062
157GBX2_23144817_ChIP-Seq_PC3_Human0.79393561
158NCOR_22424771_ChIP-Seq_293T_Human0.78649684
159CREB1_15753290_ChIP-ChIP_HEK293T_Human0.77654335
160SOX9_26525672_Chip-Seq_HEART_Mouse0.77626990
161NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.77498574

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle9.39297863
2MP0005275_abnormal_skin_tensile6.05906757
3MP0006292_abnormal_olfactory_placode4.29641516
4MP0000579_abnormal_nail_morphology4.17314106
5MP0002160_abnormal_reproductive_system2.99275724
6MP0002796_impaired_skin_barrier2.86803843
7MP0010030_abnormal_orbit_morphology2.77790181
8MP0005623_abnormal_meninges_morphology2.56454786
9MP0002249_abnormal_larynx_morphology2.43587655
10MP0003136_yellow_coat_color2.37598738
11MP0002282_abnormal_trachea_morphology2.35664738
12MP0001485_abnormal_pinna_reflex2.30296892
13MP0010678_abnormal_skin_adnexa2.16637719
14MP0002098_abnormal_vibrissa_morphology2.15525955
15MP0004145_abnormal_muscle_electrophysio2.12197490
16MP0003385_abnormal_body_wall2.07609952
17MP0008438_abnormal_cutaneous_collagen2.05298161
18MP0005503_abnormal_tendon_morphology1.96566993
19MP0004215_abnormal_myocardial_fiber1.96549278
20MP0009250_abnormal_appendicular_skeleto1.96102038
21MP0002009_preneoplasia1.93898689
22MP0003283_abnormal_digestive_organ1.93641350
23MP0005171_absent_coat_pigmentation1.85317451
24MP0003941_abnormal_skin_development1.84242060
25MP0000631_abnormal_neuroendocrine_gland1.84174348
26MP0004272_abnormal_basement_membrane1.82007763
27MP0000762_abnormal_tongue_morphology1.80717525
28MP0003123_paternal_imprinting1.75985984
29MP0005389_reproductive_system_phenotype1.75448801
30MP0002138_abnormal_hepatobiliary_system1.75235197
31MP0003646_muscle_fatigue1.73150942
32MP0005501_abnormal_skin_physiology1.70633895
33MP0000678_abnormal_parathyroid_gland1.64731453
34MP0008872_abnormal_physiological_respon1.59950711
35MP0000049_abnormal_middle_ear1.56391674
36MP0002060_abnormal_skin_morphology1.54056193
37MP0004233_abnormal_muscle_weight1.49721444
38MP0003880_abnormal_central_pattern1.49213548
39* MP0003755_abnormal_palate_morphology1.48500270
40MP0001348_abnormal_lacrimal_gland1.47569258
41* MP0005508_abnormal_skeleton_morphology1.46548548
42MP0003566_abnormal_cell_adhesion1.44645206
43MP0003119_abnormal_digestive_system1.42917584
44MP0001293_anophthalmia1.41765030
45MP0000751_myopathy1.40080095
46MP0000462_abnormal_digestive_system1.37410248
47MP0004885_abnormal_endolymph1.36681179
48MP0002932_abnormal_joint_morphology1.34898623
49MP0003705_abnormal_hypodermis_morpholog1.34684615
50MP0005646_abnormal_pituitary_gland1.33806824
51MP0002272_abnormal_nervous_system1.32487074
52MP0002938_white_spotting1.31092648
53MP0003942_abnormal_urinary_system1.28279374
54MP0002277_abnormal_respiratory_mucosa1.27330298
55* MP0000163_abnormal_cartilage_morphology1.26844690
56MP0000026_abnormal_inner_ear1.24931342
57MP0000377_abnormal_hair_follicle1.24667659
58MP0000372_irregular_coat_pigmentation1.24545815
59MP0009384_cardiac_valve_regurgitation1.23110719
60MP0006072_abnormal_retinal_apoptosis1.22967201
61MP0005385_cardiovascular_system_phenoty1.22805772
62MP0001544_abnormal_cardiovascular_syste1.22805772
63* MP0003935_abnormal_craniofacial_develop1.22325061
64MP0001958_emphysema1.21569602
65MP0002102_abnormal_ear_morphology1.20299547
66MP0002108_abnormal_muscle_morphology1.19983282
67MP0005084_abnormal_gallbladder_morpholo1.18090757
68MP0002734_abnormal_mechanical_nocicepti1.16252992
69MP0001340_abnormal_eyelid_morphology1.16023362
70* MP0002116_abnormal_craniofacial_bone1.16008869
71MP0000750_abnormal_muscle_regeneration1.14951188
72MP0002638_abnormal_pupillary_reflex1.13549533
73MP0008877_abnormal_DNA_methylation1.12423908
74MP0001486_abnormal_startle_reflex1.11884329
75MP0002735_abnormal_chemical_nociception1.10645428
76MP0005645_abnormal_hypothalamus_physiol1.08940268
77MP0001968_abnormal_touch/_nociception1.07146569
78MP0008789_abnormal_olfactory_epithelium1.07094982
79MP0004142_abnormal_muscle_tone1.07031731
80MP0004130_abnormal_muscle_cell1.06830485
81MP0002127_abnormal_cardiovascular_syste1.05022048
82MP0004085_abnormal_heartbeat1.04690729
83MP0000537_abnormal_urethra_morphology1.04431147
84MP0005330_cardiomyopathy1.04424138
85MP0001440_abnormal_grooming_behavior1.04141217
86MP0002752_abnormal_somatic_nervous1.03523080
87MP0000428_abnormal_craniofacial_morphol1.03269485
88* MP0002111_abnormal_tail_morphology1.02992392
89MP0003718_maternal_effect1.02379518
90MP0005551_abnormal_eye_electrophysiolog1.01043395
91MP0003828_pulmonary_edema0.98810477
92MP0006276_abnormal_autonomic_nervous0.98076363
93MP0005620_abnormal_muscle_contractility0.97280354
94MP0002184_abnormal_innervation0.96784438
95MP0001286_abnormal_eye_development0.96083158
96* MP0002115_abnormal_skeleton_extremities0.96062540
97MP0003045_fibrosis0.94966478
98MP0003115_abnormal_respiratory_system0.94335848
99MP0001177_atelectasis0.93618656
100MP0003638_abnormal_response/metabolism_0.93547174
101MP0002089_abnormal_postnatal_growth/wei0.93207424
102MP0001529_abnormal_vocalization0.92855385
103MP0000432_abnormal_head_morphology0.92264876
104MP0010771_integument_phenotype0.92233823
105MP0009053_abnormal_anal_canal0.92043509
106MP0004133_heterotaxia0.91737525
107MP0002653_abnormal_ependyma_morphology0.91553472
108MP0005083_abnormal_biliary_tract0.91158566
109MP0002132_abnormal_respiratory_system0.89953347
110MP0002972_abnormal_cardiac_muscle0.89341742
111MP0001963_abnormal_hearing_physiology0.89217588
112* MP0002109_abnormal_limb_morphology0.89158700
113MP0003937_abnormal_limbs/digits/tail_de0.88618424
114MP0005670_abnormal_white_adipose0.88467681
115MP0001542_abnormal_bone_strength0.87986438
116MP0002733_abnormal_thermal_nociception0.86493335
117MP0002822_catalepsy0.85343707
118MP0002210_abnormal_sex_determination0.84945997
119MP0003137_abnormal_impulse_conducting0.84487652
120MP0003567_abnormal_fetal_cardiomyocyte0.84385724
121MP0001502_abnormal_circadian_rhythm0.84259595
122MP0000013_abnormal_adipose_tissue0.83265129
123MP0003861_abnormal_nervous_system0.82923722
124MP0002254_reproductive_system_inflammat0.82910625
125MP0009379_abnormal_foot_pigmentation0.82884013
126MP0000613_abnormal_salivary_gland0.82875795
127MP0003453_abnormal_keratinocyte_physiol0.82817343
128MP0009278_abnormal_bone_marrow0.82612299
129MP0000516_abnormal_urinary_system0.82292931
130MP0005367_renal/urinary_system_phenotyp0.82292931
131MP0001188_hyperpigmentation0.81861665
132MP0000733_abnormal_muscle_development0.81502434
133MP0002233_abnormal_nose_morphology0.79765897
134MP0000534_abnormal_ureter_morphology0.79521327
135MP0008775_abnormal_heart_ventricle0.78833900
136MP0002896_abnormal_bone_mineralization0.78198006
137* MP0002114_abnormal_axial_skeleton0.77550256
138MP0002084_abnormal_developmental_patter0.75736666
139* MP0004134_abnormal_chest_morphology0.75139564
140MP0004084_abnormal_cardiac_muscle0.74962579
141MP0006138_congestive_heart_failure0.74641195
142MP0005187_abnormal_penis_morphology0.74132565
143MP0004484_altered_response_of0.73998367
144MP0008057_abnormal_DNA_replication0.73669690
145MP0000467_abnormal_esophagus_morphology0.73320389
146MP0000778_abnormal_nervous_system0.72780966
147MP0003279_aneurysm0.71994093
148MP0002163_abnormal_gland_morphology0.71214897
149MP0001919_abnormal_reproductive_system0.71152251
150MP0000647_abnormal_sebaceous_gland0.65825313
151MP0003122_maternal_imprinting0.65668077
152MP0003936_abnormal_reproductive_system0.65623109
153MP0001784_abnormal_fluid_regulation0.64021397
154MP0002837_dystrophic_cardiac_calcinosis0.63585971
155MP0002085_abnormal_embryonic_tissue0.63443737
156MP0003938_abnormal_ear_development0.63272959
157MP0004197_abnormal_fetal_growth/weight/0.62490719
158MP0002295_abnormal_pulmonary_circulatio0.61047219
159MP0005076_abnormal_cell_differentiation0.60587890
160MP0002269_muscular_atrophy0.60384555
161MP0005023_abnormal_wound_healing0.59087709
162MP0010352_gastrointestinal_tract_polyps0.58147719
163MP0000955_abnormal_spinal_cord0.56820236
164* MP0002113_abnormal_skeleton_development0.55425725
165MP0005248_abnormal_Harderian_gland0.55045173

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)7.75581080
2Concave nail (HP:0001598)5.72764571
3Pendular nystagmus (HP:0012043)5.13253088
4Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.79045066
5Septo-optic dysplasia (HP:0100842)3.96076524
6Coronal craniosynostosis (HP:0004440)3.84129377
7Hypotrichosis (HP:0001006)3.72149450
8Abnormality of the phalanges of the 2nd finger (HP:0009541)3.68498788
9Severe visual impairment (HP:0001141)3.59394067
10Sparse scalp hair (HP:0002209)3.49698477
11Premature rupture of membranes (HP:0001788)3.38045030
12Absent rod-and cone-mediated responses on ERG (HP:0007688)3.37391538
13Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.36569587
14Sex reversal (HP:0012245)3.36375914
15Abnormal sex determination (HP:0012244)3.36375914
16Abnormality of the phalanges of the 5th finger (HP:0004213)3.35013224
17Hypoplastic pelvis (HP:0008839)3.22635680
18Anomalous pulmonary venous return (HP:0010772)3.21272992
19Vertebral hypoplasia (HP:0008417)3.19855679
20Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.19855679
21True hermaphroditism (HP:0010459)3.17308010
22Right ventricular cardiomyopathy (HP:0011663)3.15299540
23Pancreatic fibrosis (HP:0100732)3.11283871
24Abnormal number of erythroid precursors (HP:0012131)3.10843199
25Erythroderma (HP:0001019)3.03962445
26Onycholysis (HP:0001806)3.00784488
27Congenital ichthyosiform erythroderma (HP:0007431)3.00533272
28Abnormality of the middle phalanges of the toes (HP:0010183)2.99344841
29Abnormality of cells of the erythroid lineage (HP:0012130)2.95361056
30Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.94770284
31Pancreatic cysts (HP:0001737)2.94676252
32Preaxial foot polydactyly (HP:0001841)2.94402374
33Abnormality of the pulmonary veins (HP:0011718)2.93469261
34Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.92951173
35Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.89984652
36Abnormality of the 2nd finger (HP:0004100)2.86208059
37Genetic anticipation (HP:0003743)2.83692989
38Short hallux (HP:0010109)2.80923034
39Protrusio acetabuli (HP:0003179)2.77775303
40Neonatal short-limb short stature (HP:0008921)2.76369701
41Porencephaly (HP:0002132)2.75436715
42Broad hallux (HP:0010055)2.73138728
43Abolished electroretinogram (ERG) (HP:0000550)2.73100058
44Thickened helices (HP:0000391)2.71614365
45Acute necrotizing encephalopathy (HP:0006965)2.71539730
46Broad toe (HP:0001837)2.69200655
47Methylmalonic acidemia (HP:0002912)2.69135693
48Increased corneal curvature (HP:0100692)2.66367910
49Keratoconus (HP:0000563)2.66367910
50Mitochondrial inheritance (HP:0001427)2.66023860
51Acanthosis nigricans (HP:0000956)2.62123965
52Rib fusion (HP:0000902)2.60351662
53Ulnar bowing (HP:0003031)2.56275503
54Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.56102791
55Short 4th metacarpal (HP:0010044)2.56102791
56Aplasia/Hypoplasia of the hallux (HP:0008362)2.55595020
57Brittle hair (HP:0002299)2.55135116
58Turricephaly (HP:0000262)2.52595111
59Bronchomalacia (HP:0002780)2.52344795
60Decreased central vision (HP:0007663)2.50266812
61Confusion (HP:0001289)2.49866458
62Conjunctival hamartoma (HP:0100780)2.45404752
63Villous atrophy (HP:0011473)2.45004277
64Abnormality of small intestinal villus morphology (HP:0011472)2.45004277
65Oral leukoplakia (HP:0002745)2.43516111
66Synostosis involving the elbow (HP:0003938)2.39417893
67Humeroradial synostosis (HP:0003041)2.39417893
68Increased hepatocellular lipid droplets (HP:0006565)2.37444366
69Thin ribs (HP:0000883)2.37269914
70Abnormal mitochondria in muscle tissue (HP:0008316)2.37231775
71Hypercortisolism (HP:0001578)2.36935160
72Hypergammaglobulinemia (HP:0010702)2.35115667
73Asplenia (HP:0001746)2.34769560
74Methylmalonic aciduria (HP:0012120)2.34411834
75Missing ribs (HP:0000921)2.32109089
76Annular pancreas (HP:0001734)2.30604139
77Abnormal rod and cone electroretinograms (HP:0008323)2.26125204
78Molar tooth sign on MRI (HP:0002419)2.26069297
79Abnormality of midbrain morphology (HP:0002418)2.26069297
80Congenital, generalized hypertrichosis (HP:0004540)2.25997759
81Acute encephalopathy (HP:0006846)2.25934195
82Hepatocellular necrosis (HP:0001404)2.25150867
83Increased CSF lactate (HP:0002490)2.24711904
84Nephronophthisis (HP:0000090)2.22712687
85Aplasia/Hypoplasia of the spleen (HP:0010451)2.20766307
86Short femoral neck (HP:0100864)2.20055054
87Partial duplication of the phalanx of hand (HP:0009999)2.18722030
883-Methylglutaconic aciduria (HP:0003535)2.17878149
89Lipid accumulation in hepatocytes (HP:0006561)2.17536188
90Agitation (HP:0000713)2.17516468
91Patent foramen ovale (HP:0001655)2.17230312
92Natal tooth (HP:0000695)2.17079951
93Redundant skin (HP:0001582)2.17060055
94Woolly hair (HP:0002224)2.16850636
95Absent septum pellucidum (HP:0001331)2.16654361
96Small hand (HP:0200055)2.14092523
97Atrial fibrillation (HP:0005110)2.12094549
98Furrowed tongue (HP:0000221)2.11574257
99Chorioretinal atrophy (HP:0000533)2.11486467
100Abnormal number of incisors (HP:0011064)2.11127619
101Abnormal hemoglobin (HP:0011902)2.08508511
102Male pseudohermaphroditism (HP:0000037)2.08388907
103Renal Fanconi syndrome (HP:0001994)2.07679499
104Progressive macrocephaly (HP:0004481)2.07414287
105Progressive cerebellar ataxia (HP:0002073)2.06638899
106Reticulocytopenia (HP:0001896)2.06215761
107Hyperparathyroidism (HP:0000843)2.05698349
108Hypoplastic left heart (HP:0004383)2.05558805
109Fibular aplasia (HP:0002990)2.04455387
110Narrow nasal bridge (HP:0000446)2.03936127
111Decreased lacrimation (HP:0000633)2.02234929
112Optic nerve hypoplasia (HP:0000609)2.01465081
113Alopecia of scalp (HP:0002293)2.00949623
114Synostosis of carpal bones (HP:0005048)2.00134533
115Absent thumb (HP:0009777)1.98518005
116Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.97319681
117Alacrima (HP:0000522)1.97222299
118Visual hallucinations (HP:0002367)1.97170928
119Facial hemangioma (HP:0000329)1.97028205
120Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.96439926
121Decreased activity of mitochondrial respiratory chain (HP:0008972)1.96439926
122Shallow orbits (HP:0000586)1.95035402
123Sclerocornea (HP:0000647)1.94003082
124Primary atrial arrhythmia (HP:0001692)1.93400054
125Wide anterior fontanel (HP:0000260)1.90450086
126Male infertility (HP:0003251)1.88252014
127Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.87922932
128Syncope (HP:0001279)1.87531433
129Supraventricular tachycardia (HP:0004755)1.87424280
130Spinal rigidity (HP:0003306)1.87275853
131Congenital sensorineural hearing impairment (HP:0008527)1.87159901
132Fibular hypoplasia (HP:0003038)1.86226655
133Hypoplastic ischia (HP:0003175)1.86018085
134Hyperglycinuria (HP:0003108)1.85155947
135Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.83862483
136Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.83469785
137Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.83355296
138Hepatic necrosis (HP:0002605)1.82792013
139Hypoplasia of the uterus (HP:0000013)1.82654385
140Abnormality of the nasal septum (HP:0000419)1.82552849
141Abnormality of the parietal bone (HP:0002696)1.82299306
142Cerebral aneurysm (HP:0004944)1.82109328
143Anencephaly (HP:0002323)1.81859795
144Distal lower limb muscle weakness (HP:0009053)1.81827067
145Abnormality of the middle phalanges of the hand (HP:0009833)1.81561315
146Cystic liver disease (HP:0006706)1.81426516
147Absent radius (HP:0003974)1.81371470
148Abnormality of the 4th metacarpal (HP:0010012)1.81283218
149Macrocytic anemia (HP:0001972)1.80706198
150Pterygium (HP:0001059)1.79916898
151Cleft eyelid (HP:0000625)1.79762496
152Supraventricular arrhythmia (HP:0005115)1.79593553
153Abnormality of homocysteine metabolism (HP:0010919)1.78639449
154Homocystinuria (HP:0002156)1.78639449
155Morphological abnormality of the middle ear (HP:0008609)1.78293227
156Abnormality of the epiphyses of the hand (HP:0005924)1.78063833
157Premature skin wrinkling (HP:0100678)1.77986828
158Short humerus (HP:0005792)1.77931386
159Overgrowth (HP:0001548)1.77872801
160Increased intramyocellular lipid droplets (HP:0012240)1.77828300
161Aplasia/Hypoplasia of the patella (HP:0006498)1.77322540
162Oligodactyly (HP:0012165)1.77273877
163Adrenal hypoplasia (HP:0000835)1.75588846
164Abnormality of the umbilical cord (HP:0010881)1.73756226
165Preauricular pit (HP:0004467)1.73460032
166Periauricular skin pits (HP:0100277)1.73460032
167Abnormality of the septum pellucidum (HP:0007375)1.73245094
168Gynecomastia (HP:0000771)1.72748367
169Mild short stature (HP:0003502)1.72719498
170Choanal stenosis (HP:0000452)1.72216226
171Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.70213024
172Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.69015052
173Increased number of teeth (HP:0011069)1.69001564
174Emphysema (HP:0002097)1.68961472
175Abnormality of the ischium (HP:0003174)1.68683207
176Fragile skin (HP:0001030)1.68567818
177Absent forearm bone (HP:0003953)1.68394526
178Aplasia involving forearm bones (HP:0009822)1.68394526
179Down-sloping shoulders (HP:0200021)1.67863970
180Epiphyseal dysplasia (HP:0002656)1.66988318
181Abnormality of the gastric mucosa (HP:0004295)1.66101318
182Popliteal pterygium (HP:0009756)1.65983123
183Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.64445515
184Multiple lipomas (HP:0001012)1.63717988
185Increased connective tissue (HP:0009025)1.61710024
186Aplasia/hypoplasia of the humerus (HP:0006507)1.60911028
187Hypercalcemia (HP:0003072)1.59709302
188Aplasia/Hypoplasia of the sternum (HP:0006714)1.58995837
189Midline defect of the nose (HP:0004122)1.58650162
190Aplasia involving bones of the extremities (HP:0009825)1.58371842
191Aplasia involving bones of the upper limbs (HP:0009823)1.58371842
192Aplasia of the phalanges of the hand (HP:0009802)1.58371842

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.88813256
2ICK4.04816085
3MAP3K63.88126323
4VRK23.56102105
5MAPK153.43459809
6NUAK13.05357035
7MAPKAPK32.99697611
8MYLK2.84637208
9LMTK22.74978499
10ADRBK22.74434927
11LATS22.73642419
12BCR2.54925382
13CDC72.52036882
14STK162.50467298
15EEF2K2.47019878
16EPHB22.35176409
17TRPM72.33188616
18PIM22.31293910
19PINK12.29184943
20MAP3K112.07181804
21NME22.06169502
22PDGFRA2.03370552
23MUSK1.86109557
24TYRO31.84576417
25FGR1.79783027
26VRK11.77388560
27UHMK11.77268796
28NME11.69340967
29STK241.68556532
30TNIK1.68067268
31MAP3K91.62335893
32BUB11.57095607
33CASK1.56959322
34BMX1.55958502
35DMPK1.49310661
36GRK71.48180892
37PHKG21.44627627
38PHKG11.44627627
39ABL21.42413442
40MATK1.39575129
41PNCK1.36474044
42DAPK11.34691760
43RPS6KB21.32225957
44PRKD21.24720464
45ACVR1B1.23600476
46MAPK111.22410710
47TAF11.21115106
48YES11.20642269
49CDC42BPA1.15128326
50AURKA1.13713134
51CDK61.11945381
52PKN11.09649593
53DYRK1B1.09327166
54PLK41.08447706
55WNK31.05108273
56ZAK1.04064750
57MKNK21.03847558
58HIPK21.03066085
59RPS6KC11.02359514
60RPS6KL11.02359514
61MARK11.01650865
62PDK20.99976032
63OBSCN0.98454600
64STK40.97544789
65PRKCG0.96115528
66GSK3A0.95254045
67ROCK10.93044716
68PLK10.92878922
69MAPK130.92506207
70CSK0.92140879
71TTN0.90147782
72MINK10.90040941
73MST40.89348818
74AURKB0.89024682
75CAMK10.88591032
76TIE10.87319079
77PRKCI0.85430817
78FER0.83914852
79RPS6KA60.79968736
80PBK0.79599016
81EPHA30.75269310
82PRKACA0.73105951
83DYRK20.71866883
84STK38L0.71156122
85PRKG20.69190784
86LATS10.68233774
87CDK70.67859811
88EPHA40.67700174
89TAOK20.66731539
90STK30.65466470
91MTOR0.65225863
92WNK40.65130977
93RAF10.61853436
94CSNK1G20.61098570
95ERBB30.61010706
96TAOK10.60753920
97CSNK1A10.60466032
98EPHA20.60446716
99PLK30.60055579
100CSNK2A10.58794162
101TESK20.58077022
102DAPK30.57629198
103PRKAA10.55211086
104PRKD10.52726387
105PAK30.52260518
106ERBB20.52202718
107RPS6KA10.51785748
108GRK50.51727077
109CHEK20.51470443
110RPS6KA20.51101936
111MAP3K30.50862326
112ADRBK10.50709806
113CSNK1G30.50404045
114MAPK100.50097917
115MAPK40.49980047
116CAMK2D0.48939168
117STK110.48396448
118CAMK2G0.48224880
119RPS6KA50.47998826
120CAMK2A0.47527206
121MAP3K50.46685589
122INSRR0.46591368
123NTRK20.45481877
124CHEK10.43918567
125MAPK90.43028961
126PAK20.42451721
127PTK20.41827926
128NTRK10.41573227
129CSNK1G10.41141701
130ERBB40.40903268
131ILK0.40113128
132CAMK40.40012791
133CSNK1E0.38508939
134CSNK2A20.38097609
135BMPR1B0.37823781
136CAMK2B0.37621120
137DYRK30.37446772
138CSNK1A1L0.37185406
139PAK60.37080655
140MELK0.37015849
141CDK11A0.34848669
142EIF2AK10.34361014
143PRKCA0.34310802
144GRK10.33388995
145PIM10.33387827
146MAP2K70.33354965
147TLK10.33066150
148PRKACG0.33032479
149RPS6KB10.32803902
150MAPK30.32394582
151PRKG10.31445180
152MARK20.30574946
153MAPKAPK20.29126292
154CDK140.28915928
155MAPK10.28518478
156PRKCE0.28034568
157TRIB30.28015742
158PRKAA20.27648501
159PRKCZ0.27608514

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.75166677
2Hedgehog signaling pathway_Homo sapiens_hsa043403.50232577
3Hippo signaling pathway_Homo sapiens_hsa043903.34660084
4TGF-beta signaling pathway_Homo sapiens_hsa043503.23063191
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.84555502
6Fatty acid biosynthesis_Homo sapiens_hsa000612.83421692
7RNA polymerase_Homo sapiens_hsa030202.78976976
8Adherens junction_Homo sapiens_hsa045202.49058678
9Homologous recombination_Homo sapiens_hsa034402.38533959
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.28262329
11Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.25130516
12Wnt signaling pathway_Homo sapiens_hsa043102.21066920
13ECM-receptor interaction_Homo sapiens_hsa045122.11901651
14Melanogenesis_Homo sapiens_hsa049161.82238746
15Proteasome_Homo sapiens_hsa030501.74962782
16Cardiac muscle contraction_Homo sapiens_hsa042601.74783232
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.73555180
18Dilated cardiomyopathy_Homo sapiens_hsa054141.72181690
19Bladder cancer_Homo sapiens_hsa052191.69222455
20Proteoglycans in cancer_Homo sapiens_hsa052051.66414507
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.65269412
22Focal adhesion_Homo sapiens_hsa045101.58716606
23Tight junction_Homo sapiens_hsa045301.57575503
24Axon guidance_Homo sapiens_hsa043601.56083111
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.55554600
26p53 signaling pathway_Homo sapiens_hsa041151.51885868
27Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.51489605
28Vitamin digestion and absorption_Homo sapiens_hsa049771.49484099
29Spliceosome_Homo sapiens_hsa030401.46713911
30Arginine and proline metabolism_Homo sapiens_hsa003301.43848586
31Protein export_Homo sapiens_hsa030601.42430105
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.42419000
33Nicotine addiction_Homo sapiens_hsa050331.40777330
34DNA replication_Homo sapiens_hsa030301.35587423
35Gap junction_Homo sapiens_hsa045401.35483017
36Notch signaling pathway_Homo sapiens_hsa043301.34292699
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.33948932
38Ribosome_Homo sapiens_hsa030101.32242459
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31969114
40Basal transcription factors_Homo sapiens_hsa030221.31741549
41Olfactory transduction_Homo sapiens_hsa047401.29746682
42MicroRNAs in cancer_Homo sapiens_hsa052061.29725446
43Circadian rhythm_Homo sapiens_hsa047101.26693696
44RNA degradation_Homo sapiens_hsa030181.25876478
45* Regulation of actin cytoskeleton_Homo sapiens_hsa048101.24017233
46Sulfur metabolism_Homo sapiens_hsa009201.15945724
47Oxidative phosphorylation_Homo sapiens_hsa001901.12986919
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09129222
49Longevity regulating pathway - mammal_Homo sapiens_hsa042111.08244839
50Protein digestion and absorption_Homo sapiens_hsa049741.05932032
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05014365
52Parkinsons disease_Homo sapiens_hsa050121.04617517
53Dorso-ventral axis formation_Homo sapiens_hsa043201.04277551
54Morphine addiction_Homo sapiens_hsa050321.04060873
55Folate biosynthesis_Homo sapiens_hsa007901.01889012
56Selenocompound metabolism_Homo sapiens_hsa004501.01421108
57* Pathways in cancer_Homo sapiens_hsa052001.00530717
58Huntingtons disease_Homo sapiens_hsa050160.99913480
59ErbB signaling pathway_Homo sapiens_hsa040120.98772360
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98732503
61RNA transport_Homo sapiens_hsa030130.97370529
62Viral myocarditis_Homo sapiens_hsa054160.97156371
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.96276010
64Small cell lung cancer_Homo sapiens_hsa052220.96101940
65Alzheimers disease_Homo sapiens_hsa050100.95991085
66Fanconi anemia pathway_Homo sapiens_hsa034600.95228431
67Chemical carcinogenesis_Homo sapiens_hsa052040.94397567
68* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.93944521
69* Melanoma_Homo sapiens_hsa052180.91726140
70Linoleic acid metabolism_Homo sapiens_hsa005910.91294924
71mTOR signaling pathway_Homo sapiens_hsa041500.91104384
72* Rap1 signaling pathway_Homo sapiens_hsa040150.90242069
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84950881
74Glutamatergic synapse_Homo sapiens_hsa047240.84900237
75GnRH signaling pathway_Homo sapiens_hsa049120.83541948
76One carbon pool by folate_Homo sapiens_hsa006700.82805038
77Oocyte meiosis_Homo sapiens_hsa041140.79064230
78Colorectal cancer_Homo sapiens_hsa052100.78876654
79Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.78620579
80Amphetamine addiction_Homo sapiens_hsa050310.78414317
81Lysine degradation_Homo sapiens_hsa003100.75186280
82* Ras signaling pathway_Homo sapiens_hsa040140.74072674
83Fatty acid elongation_Homo sapiens_hsa000620.73886172
84* MAPK signaling pathway_Homo sapiens_hsa040100.73754129
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72971127
86Pyruvate metabolism_Homo sapiens_hsa006200.72843945
87Tryptophan metabolism_Homo sapiens_hsa003800.71731522
88Estrogen signaling pathway_Homo sapiens_hsa049150.70274049
89Oxytocin signaling pathway_Homo sapiens_hsa049210.69238176
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69011404
91Pyrimidine metabolism_Homo sapiens_hsa002400.68259135
92Mismatch repair_Homo sapiens_hsa034300.67766611
93Glioma_Homo sapiens_hsa052140.67471225
94Nucleotide excision repair_Homo sapiens_hsa034200.67123933
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65371495
96Purine metabolism_Homo sapiens_hsa002300.65073542
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64490460
98Caffeine metabolism_Homo sapiens_hsa002320.64144955
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64135062
100Base excision repair_Homo sapiens_hsa034100.63868371
101Systemic lupus erythematosus_Homo sapiens_hsa053220.63746513
102Amoebiasis_Homo sapiens_hsa051460.63617872
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62399659
104Salivary secretion_Homo sapiens_hsa049700.61656689
105Serotonergic synapse_Homo sapiens_hsa047260.61440503
106Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61436307
107Insulin secretion_Homo sapiens_hsa049110.61197438
108cAMP signaling pathway_Homo sapiens_hsa040240.60814271
109Nitrogen metabolism_Homo sapiens_hsa009100.60481813
110VEGF signaling pathway_Homo sapiens_hsa043700.59906787
111Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58954805
112HTLV-I infection_Homo sapiens_hsa051660.57893711
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57491148
114Renin secretion_Homo sapiens_hsa049240.57475635
115Phototransduction_Homo sapiens_hsa047440.56189710
116Gastric acid secretion_Homo sapiens_hsa049710.56128032
117Long-term depression_Homo sapiens_hsa047300.54624499
118Maturity onset diabetes of the young_Homo sapiens_hsa049500.53912289
119Thyroid cancer_Homo sapiens_hsa052160.53493373
120Fatty acid metabolism_Homo sapiens_hsa012120.53060472
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51502397
122Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51098447
123Alcoholism_Homo sapiens_hsa050340.51044523
124Taste transduction_Homo sapiens_hsa047420.50829982
125Propanoate metabolism_Homo sapiens_hsa006400.50798381
126Dopaminergic synapse_Homo sapiens_hsa047280.50106391
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50065696
128Retinol metabolism_Homo sapiens_hsa008300.50005109
129Insulin signaling pathway_Homo sapiens_hsa049100.48776385
130Circadian entrainment_Homo sapiens_hsa047130.48491398
131Prostate cancer_Homo sapiens_hsa052150.48202869
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47543781
133Steroid hormone biosynthesis_Homo sapiens_hsa001400.46779986
134Chronic myeloid leukemia_Homo sapiens_hsa052200.46166091
135AMPK signaling pathway_Homo sapiens_hsa041520.44513549
136Endometrial cancer_Homo sapiens_hsa052130.43759539
137Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43405581
138Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43262624
139Calcium signaling pathway_Homo sapiens_hsa040200.42681687
140Glutathione metabolism_Homo sapiens_hsa004800.41764708
141Metabolic pathways_Homo sapiens_hsa011000.41311065
142Cell cycle_Homo sapiens_hsa041100.40822950
143Endocytosis_Homo sapiens_hsa041440.40380597
144GABAergic synapse_Homo sapiens_hsa047270.39786507
145Cholinergic synapse_Homo sapiens_hsa047250.39712200
146Choline metabolism in cancer_Homo sapiens_hsa052310.39210054
147Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.38613713
148Ovarian steroidogenesis_Homo sapiens_hsa049130.37547991
149FoxO signaling pathway_Homo sapiens_hsa040680.37443804
150Cocaine addiction_Homo sapiens_hsa050300.37309883
151Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35559962
152Pancreatic cancer_Homo sapiens_hsa052120.35525588
153Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34942500
154Vascular smooth muscle contraction_Homo sapiens_hsa042700.33739487
155Sulfur relay system_Homo sapiens_hsa041220.33454506
156Cysteine and methionine metabolism_Homo sapiens_hsa002700.29099257
157Glycerolipid metabolism_Homo sapiens_hsa005610.28627888

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