FGF20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the fibroblast growth factor family. The fibroblast growth factors possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene product is a secreted neurotrophic factor but lacks a typical signal peptide. It is expressed in normal brain, particularly the cerebellum, and may regulate central nervous system development and function. Homodimerization of this protein was shown to regulate its receptor binding activity and concentration gradient in the extracellular matrix. Genetic variations of this gene have been associated with Parkinson disease susceptibility. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of phospholipase A2 activity (GO:0032429)9.46290515
2regulation of skeletal muscle contraction (GO:0014819)8.13410281
3cellular potassium ion homeostasis (GO:0030007)7.64632146
4negative regulation of lipase activity (GO:0060192)7.46902121
5uronic acid metabolic process (GO:0006063)7.35716966
6glucuronate metabolic process (GO:0019585)7.35716966
7negative regulation of organic acid transport (GO:0032891)7.09409171
8replicative senescence (GO:0090399)6.91494273
9cellular glucuronidation (GO:0052695)6.83812402
10positive regulation of icosanoid secretion (GO:0032305)6.77364475
11chaperone-mediated protein transport (GO:0072321)6.67246906
12amyloid precursor protein catabolic process (GO:0042987)6.05857721
13neuronal ion channel clustering (GO:0045161)5.99142559
14regulation of memory T cell differentiation (GO:0043380)5.75592424
15relaxation of cardiac muscle (GO:0055119)5.74952288
16positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)5.72835917
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.71686301
18positive regulation of fatty acid transport (GO:2000193)5.59168702
19one-carbon compound transport (GO:0019755)5.57776943
20RNA destabilization (GO:0050779)5.54036689
21energy homeostasis (GO:0097009)5.53866721
22xenobiotic catabolic process (GO:0042178)5.43150440
23Notch signaling involved in heart development (GO:0061314)5.40216800
24membrane repolarization during cardiac muscle cell action potential (GO:0086013)5.40043169
25regulation of icosanoid secretion (GO:0032303)5.09712766
26membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.09005828
27positive regulation of signal transduction by p53 class mediator (GO:1901798)4.94212200
28regulation of cholesterol biosynthetic process (GO:0045540)4.80680568
29membrane repolarization during action potential (GO:0086011)4.76337096
30regulation of fatty acid transport (GO:2000191)4.75955589
31phenylpropanoid metabolic process (GO:0009698)4.75537365
32heterotypic cell-cell adhesion (GO:0034113)4.71535660
33DNA deamination (GO:0045006)4.67162464
34energy coupled proton transport, down electrochemical gradient (GO:0015985)4.66796990
35ATP synthesis coupled proton transport (GO:0015986)4.66796990
36regulation of mitochondrial translation (GO:0070129)4.58495791
37positive regulation of fatty acid beta-oxidation (GO:0032000)4.57373882
38positive regulation of macrophage activation (GO:0043032)4.56195419
39respiratory chain complex IV assembly (GO:0008535)4.51495067
40auditory receptor cell differentiation (GO:0042491)4.44856918
41GTP biosynthetic process (GO:0006183)4.43227840
42negative regulation of lipid transport (GO:0032369)4.39620722
43potassium ion import (GO:0010107)4.38419807
44nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.28703919
45male sex determination (GO:0030238)4.25807183
46calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.24752894
47ovulation cycle (GO:0042698)4.24215920
48amyloid precursor protein metabolic process (GO:0042982)4.23575062
49maturation of 5.8S rRNA (GO:0000460)4.22621046
50pseudouridine synthesis (GO:0001522)4.20423885
51sperm capacitation (GO:0048240)4.20396646
52membrane repolarization (GO:0086009)4.18025379
53relaxation of muscle (GO:0090075)4.12412216
54metallo-sulfur cluster assembly (GO:0031163)4.07300059
55iron-sulfur cluster assembly (GO:0016226)4.07300059
56negative regulation of inclusion body assembly (GO:0090084)4.06322832
57exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.03961964
58cell differentiation involved in metanephros development (GO:0072202)4.00317401
59potassium ion homeostasis (GO:0055075)3.98567164
60behavioral response to nicotine (GO:0035095)3.95537523
61neurotransmitter uptake (GO:0001504)3.95405970
62negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.95053317
63cytochrome complex assembly (GO:0017004)3.94504145
64histone H2A ubiquitination (GO:0033522)3.92991301
65tolerance induction (GO:0002507)3.91740743
66response to nitrosative stress (GO:0051409)3.90094774
67positive regulation of prostaglandin secretion (GO:0032308)3.86205493
68auditory receptor cell stereocilium organization (GO:0060088)3.84323610
69UTP biosynthetic process (GO:0006228)3.83478412
70lipopolysaccharide biosynthetic process (GO:0009103)3.77647350
71flavonoid metabolic process (GO:0009812)3.77109569
72peroxisome fission (GO:0016559)3.76646408
73positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.76556585
74negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.76520840
75establishment of protein localization to mitochondrial membrane (GO:0090151)3.73489047
76mannosylation (GO:0097502)3.73021394
77positive regulation of potassium ion transmembrane transport (GO:1901381)3.72987825
78protein complex biogenesis (GO:0070271)3.72535440
79regulation of sequestering of triglyceride (GO:0010889)3.69782839
80mitochondrial respiratory chain complex assembly (GO:0033108)3.68868077
81L-ascorbic acid metabolic process (GO:0019852)3.64161986
82epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.60370087
83metanephric mesenchyme development (GO:0072075)3.54458745
84beta-amyloid metabolic process (GO:0050435)3.54179987
85atrial cardiac muscle cell action potential (GO:0086014)3.53718853
86viral protein processing (GO:0019082)3.52826825
87magnesium ion transport (GO:0015693)3.49925998
88endocardial cushion morphogenesis (GO:0003203)3.46241957
89positive regulation of vesicle fusion (GO:0031340)3.45954266
90positive regulation of defense response to virus by host (GO:0002230)3.45483707
91aorta morphogenesis (GO:0035909)3.45075293
92respiratory electron transport chain (GO:0022904)3.44463167
93sleep (GO:0030431)3.43224753
94mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.40596451
95natural killer cell activation involved in immune response (GO:0002323)3.38417550
96positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.38006221
97positive regulation of hormone biosynthetic process (GO:0046886)3.37861228
98electron transport chain (GO:0022900)3.37698296
99positive regulation of steroid biosynthetic process (GO:0010893)3.37284682
100nucleotide transmembrane transport (GO:1901679)3.35762993
101myelin maintenance (GO:0043217)3.35714909
102histone H2A monoubiquitination (GO:0035518)3.33244700
103regulation of synaptic transmission, dopaminergic (GO:0032225)3.32186174
104proline transport (GO:0015824)3.30812064
105UTP metabolic process (GO:0046051)3.29077952
106positive regulation of cell fate commitment (GO:0010455)3.27376060
107regulation of interleukin-13 production (GO:0032656)3.27107996
108cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.26611485
109regulation of immunoglobulin secretion (GO:0051023)3.23681702
110glomerulus development (GO:0032835)3.20846977
111positive regulation of type 2 immune response (GO:0002830)3.19245927
112thalamus development (GO:0021794)3.18951993
113kidney mesenchyme development (GO:0072074)3.18624457
114regulation of secondary heart field cardioblast proliferation (GO:0003266)3.17783307
115regulation of cardioblast proliferation (GO:0003264)3.17783307
116regulation of mitotic spindle checkpoint (GO:1903504)3.16113884
117regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.16113884
118positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.13403510
119regulation of activation of Janus kinase activity (GO:0010533)3.12002818
120negative regulation of glucose import (GO:0046325)3.11983422
121regulation of prostaglandin secretion (GO:0032306)3.11032728
122positive regulation of synapse maturation (GO:0090129)3.10068449
123benzene-containing compound metabolic process (GO:0042537)3.09704086
124protein localization to cilium (GO:0061512)3.09240760
125nucleoside diphosphate phosphorylation (GO:0006165)3.08625271
126mitochondrial respiratory chain complex I assembly (GO:0032981)3.07890700
127NADH dehydrogenase complex assembly (GO:0010257)3.07890700
128mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.07890700
129regulation of centrosome duplication (GO:0010824)3.07074668
130positive regulation of organic acid transport (GO:0032892)3.06116394
131positive regulation of fatty acid oxidation (GO:0046321)3.05271025
132inner ear receptor stereocilium organization (GO:0060122)3.04665156
133multicellular organism reproduction (GO:0032504)3.04559215
134regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.02706961
135purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.02607020
136regulation of inclusion body assembly (GO:0090083)3.02287741
137positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.01467354
138regulation of heart rate by cardiac conduction (GO:0086091)3.00359196
139regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.99857630
140outer ear morphogenesis (GO:0042473)2.98993213
141purine nucleoside triphosphate biosynthetic process (GO:0009145)2.97800537
142lipopolysaccharide metabolic process (GO:0008653)2.97708013
143glutamate secretion (GO:0014047)2.95908861
144negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.95147256
145positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.94943344
146regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.94943344
147glycerophospholipid catabolic process (GO:0046475)2.93436004
148regulation of centrosome cycle (GO:0046605)2.92163870
149regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.90935489
150guanosine-containing compound biosynthetic process (GO:1901070)2.90679005
151epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.90621545
152tight junction assembly (GO:0070830)2.89582562
153alanine transport (GO:0032328)2.88054228
154negative regulation of translation, ncRNA-mediated (GO:0040033)2.86854352
155regulation of translation, ncRNA-mediated (GO:0045974)2.86854352
156negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.86854352
157preassembly of GPI anchor in ER membrane (GO:0016254)2.86708401
158UV protection (GO:0009650)2.85226194
159type B pancreatic cell development (GO:0003323)2.84811482
160outflow tract septum morphogenesis (GO:0003148)2.84784664
161regulation of fatty acid beta-oxidation (GO:0031998)2.82616860
162nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288)2.82438206
163regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043516)2.81977480
164cellular senescence (GO:0090398)2.81330213
165synaptic transmission, cholinergic (GO:0007271)2.80414822
166adenosine metabolic process (GO:0046085)2.78909585
167positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.78545983
168regulation of defense response to virus by host (GO:0050691)2.78168949
169sperm motility (GO:0030317)2.76600152
170regulation of superoxide anion generation (GO:0032928)2.76083932
171intracellular protein transmembrane import (GO:0044743)2.75995070
172regulation of cholesterol metabolic process (GO:0090181)2.75900839
173water-soluble vitamin biosynthetic process (GO:0042364)2.74096702
174positive regulation of activated T cell proliferation (GO:0042104)2.73501505
175positive regulation of receptor recycling (GO:0001921)2.72818889
176somatic diversification of immune receptors via somatic mutation (GO:0002566)2.71956656
177somatic hypermutation of immunoglobulin genes (GO:0016446)2.71956656
178lactate metabolic process (GO:0006089)2.71955162
179negative regulation of cell killing (GO:0031342)2.71492263
180negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.71492263
181negative regulation of organ growth (GO:0046621)2.70845173
182positive regulation of glycogen biosynthetic process (GO:0045725)2.68306475
183sex determination (GO:0007530)2.68279634
184hydrogen ion transmembrane transport (GO:1902600)2.67978819
185response to dietary excess (GO:0002021)2.66928216
186endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.66790952
187nephron epithelium morphogenesis (GO:0072088)2.65384181
188nephron tubule morphogenesis (GO:0072078)2.65384181
189positive regulation of mesonephros development (GO:0061213)2.61471915
190misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.60601123
191transmission of nerve impulse (GO:0019226)2.60490554
192negative regulation of transcription regulatory region DNA binding (GO:2000678)2.60142810
193muscle cell migration (GO:0014812)2.59279560
194middle ear morphogenesis (GO:0042474)2.58570493
195hair cell differentiation (GO:0035315)2.56504607
196regulation of organic acid transport (GO:0032890)2.53405379
197negative regulation of fatty acid transport (GO:2000192)16.2961382
198regulation of chemokine secretion (GO:0090196)10.6468185
199positive regulation of chemokine secretion (GO:0090197)10.2323101

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.32894940
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.08584040
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.78881153
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.22744571
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.97569128
6ESR2_21235772_ChIP-Seq_MCF-7_Human2.87230615
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.82554539
8AR_21572438_ChIP-Seq_LNCaP_Human2.73461985
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.72511592
10DROSHA_22980978_ChIP-Seq_HELA_Human2.69864933
11HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.69351523
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.63073965
13RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.53016273
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.51566362
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.50415051
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.47225516
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.44177622
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.42509989
19CLOCK_20551151_ChIP-Seq_293T_Human2.39819098
20MYC_18940864_ChIP-ChIP_HL60_Human2.30856121
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.29660158
22CDX2_20551321_ChIP-Seq_CACO-2_Human2.22476104
23AHR_22903824_ChIP-Seq_MCF-7_Human2.20677962
24TAF15_26573619_Chip-Seq_HEK293_Human2.18838385
25TP53_18474530_ChIP-ChIP_U2OS_Human2.16587244
26FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.14485664
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.98906125
28NR3C1_21868756_ChIP-Seq_MCF10A_Human1.92345550
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.90540752
30* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.90147913
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84968962
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.84007286
33ZNF217_24962896_ChIP-Seq_MCF-7_Human1.83415833
34VDR_23849224_ChIP-Seq_CD4+_Human1.81942579
35NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.81419473
36NRF2_20460467_ChIP-Seq_MEFs_Mouse1.81419473
37SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.80833634
38ELK1_19687146_ChIP-ChIP_HELA_Human1.79315480
39CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.76850886
40* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.67453549
41ARNT_22903824_ChIP-Seq_MCF-7_Human1.66036724
42* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.62865627
43FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.62178262
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59938356
45GATA3_21878914_ChIP-Seq_MCF-7_Human1.59608722
46* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.59372053
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.58411574
48TP53_22573176_ChIP-Seq_HFKS_Human1.56295974
49* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.56200327
50* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.56200327
51ETS1_20019798_ChIP-Seq_JURKAT_Human1.54887856
52P53_22127205_ChIP-Seq_FIBROBLAST_Human1.53252153
53ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.53191069
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.52785927
55FOXP3_21729870_ChIP-Seq_TREG_Human1.52164246
56EED_16625203_ChIP-ChIP_MESCs_Mouse1.50528270
57CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.50046326
58RXR_22158963_ChIP-Seq_LIVER_Mouse1.49975556
59KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.48949045
60KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.48949045
61KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.48949045
62* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46639325
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39161749
64PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.38238187
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38206438
66EZH2_22144423_ChIP-Seq_EOC_Human1.38083670
67SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.36623668
68* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.36518078
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35407810
70CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.35375770
71ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.35252973
72LXR_22158963_ChIP-Seq_LIVER_Mouse1.35088919
73* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.34259118
74* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.33043513
75GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.32619945
76CREB1_15753290_ChIP-ChIP_HEK293T_Human1.31669647
77ESR1_20079471_ChIP-ChIP_T-47D_Human1.31647734
78MYC_18555785_ChIP-Seq_MESCs_Mouse1.31242562
79RING1B_27294783_Chip-Seq_ESCs_Mouse1.30973394
80* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.30558468
81FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30453813
82FOXA1_25329375_ChIP-Seq_VCAP_Human1.30453813
83PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30009822
84REST_21632747_ChIP-Seq_MESCs_Mouse1.29764672
85MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29179376
86PIAS1_25552417_ChIP-Seq_VCAP_Human1.28556555
87E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.27467644
88THAP11_20581084_ChIP-Seq_MESCs_Mouse1.26226926
89ELF1_17652178_ChIP-ChIP_JURKAT_Human1.25710102
90GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22959087
91FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22508848
92EWS_26573619_Chip-Seq_HEK293_Human1.21761291
93JARID2_20075857_ChIP-Seq_MESCs_Mouse1.20792050
94TDRD3_21172665_ChIP-Seq_MCF-7_Human1.20035654
95CBX2_27304074_Chip-Seq_ESCs_Mouse1.19783064
96SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19510462
97ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19338154
98FOXM1_26456572_ChIP-Seq_MCF-7_Human1.19256233
99BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.18690825
100SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18684367
101SRY_22984422_ChIP-ChIP_TESTIS_Rat1.18253316
102EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16259904
103AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15684073
104POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15288496
105HOXB7_26014856_ChIP-Seq_BT474_Human1.14766180
106TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14725258
107OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14394133
108PRDM14_20953172_ChIP-Seq_ESCs_Human1.13745303
109* EP300_21415370_ChIP-Seq_HL-1_Mouse1.11377217
110TP53_20018659_ChIP-ChIP_R1E_Mouse1.10349850
111RNF2_27304074_Chip-Seq_ESCs_Mouse1.09937107
112CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09531468
113JARID2_20064375_ChIP-Seq_MESCs_Mouse1.09325553
114VDR_22108803_ChIP-Seq_LS180_Human1.09030687
115* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08930541
116OCT4_20526341_ChIP-Seq_ESCs_Human1.08659673
117PPARA_22158963_ChIP-Seq_LIVER_Mouse1.08236175
118RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07486558
119TCF3_18692474_ChIP-Seq_MEFs_Mouse1.07366314
120CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.06371502
121RING1B_27294783_Chip-Seq_NPCs_Mouse1.04527169
122NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04468510
123E2F1_18555785_ChIP-Seq_MESCs_Mouse1.03596121
124EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03452058
125* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02746570
126NANOG_19829295_ChIP-Seq_ESCs_Human1.02744540
127SOX2_19829295_ChIP-Seq_ESCs_Human1.02744540
128PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.01982635
129STAT1_20625510_ChIP-Seq_HELA_Human1.01663056
130EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.01488247
131FOXO3_23340844_ChIP-Seq_DLD1_Human1.00732729
132P300_19829295_ChIP-Seq_ESCs_Human1.00710842
133* SMAD3_21741376_ChIP-Seq_EPCs_Human0.99505756
134WDR5_24793694_ChIP-Seq_LNCAP_Human0.99095105
135WT1_19549856_ChIP-ChIP_CCG9911_Human0.98811503
136ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97597098
137IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97419506
138CBP_20019798_ChIP-Seq_JUKART_Human0.97419506
139TP53_16413492_ChIP-PET_HCT116_Human0.97053968
140* TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96958415
141FUS_26573619_Chip-Seq_HEK293_Human0.96778215
142* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96143656
143ERA_21632823_ChIP-Seq_H3396_Human0.95740920
144BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95236145
145IGF1R_20145208_ChIP-Seq_DFB_Human0.95004682
146CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94976756
147EZH2_27304074_Chip-Seq_ESCs_Mouse0.94433105
148PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94135315
149TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93758408
150CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.93446220
151SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.93051816
152TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.92904812
153RNF2_27304074_Chip-Seq_NSC_Mouse0.92857968
154* REST_18959480_ChIP-ChIP_MESCs_Mouse0.92778066
155TTF2_22483619_ChIP-Seq_HELA_Human0.92720648
156GBX2_23144817_ChIP-Seq_PC3_Human0.92288522
157LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92193615
158EZH2_27294783_Chip-Seq_ESCs_Mouse0.91979564
159AR_25329375_ChIP-Seq_VCAP_Human0.90875522
160ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90623196
161RUNX1_27514584_Chip-Seq_MCF-7_Human0.90473652
162FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.90372241
163TCF4_22108803_ChIP-Seq_LS180_Human0.89908239
164* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89331147
165RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.89217138
166ZNF274_21170338_ChIP-Seq_K562_Hela0.89008869
167SOX2_20726797_ChIP-Seq_SW620_Human0.88720738
168YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88203147
169TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87351838
170TP63_23658742_ChIP-Seq_EP156T_Human0.87191159
171XRN2_22483619_ChIP-Seq_HELA_Human0.86362657
172SMAD3_21741376_ChIP-Seq_ESCs_Human0.83905154
173SOX2_21211035_ChIP-Seq_LN229_Human0.83506803
174HTT_18923047_ChIP-ChIP_STHdh_Human0.83219998
175TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.82964701
176FLI1_21867929_ChIP-Seq_TH2_Mouse0.82960621
177MYC_18358816_ChIP-ChIP_MESCs_Mouse0.82954009
178SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.81856697
179STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.80456250
180* CTBP1_25329375_ChIP-Seq_LNCAP_Human0.79941809
181MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.79799346
182YY1_21170310_ChIP-Seq_MESCs_Mouse0.79418747

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008789_abnormal_olfactory_epithelium7.44188242
2MP0005394_taste/olfaction_phenotype6.14245829
3MP0005499_abnormal_olfactory_system6.14245829
4MP0001984_abnormal_olfaction5.49616511
5MP0010030_abnormal_orbit_morphology4.83574948
6MP0003941_abnormal_skin_development4.41848641
7MP0005377_hearing/vestibular/ear_phenot3.44002065
8MP0003878_abnormal_ear_physiology3.44002065
9MP0008875_abnormal_xenobiotic_pharmacok3.39600551
10MP0000372_irregular_coat_pigmentation3.16498081
11MP0003136_yellow_coat_color3.15433869
12MP0006072_abnormal_retinal_apoptosis3.04787027
13MP0003646_muscle_fatigue2.99737133
14MP0002102_abnormal_ear_morphology2.97054246
15MP0009053_abnormal_anal_canal2.86979636
16MP0002233_abnormal_nose_morphology2.77367515
17MP0002938_white_spotting2.76432239
18MP0008877_abnormal_DNA_methylation2.75605681
19MP0005248_abnormal_Harderian_gland2.75454017
20MP0004133_heterotaxia2.59302128
21MP0005646_abnormal_pituitary_gland2.58362343
22MP0001919_abnormal_reproductive_system2.34202284
23MP0002009_preneoplasia2.26600550
24MP0003638_abnormal_response/metabolism_1.76389020
25MP0000631_abnormal_neuroendocrine_gland1.72658781
26MP0002638_abnormal_pupillary_reflex1.72619528
27MP0000534_abnormal_ureter_morphology1.69872793
28MP0002139_abnormal_hepatobiliary_system1.67840788
29MP0009046_muscle_twitch1.67433499
30MP0001968_abnormal_touch/_nociception1.65300663
31MP0005174_abnormal_tail_pigmentation1.64928785
32MP0005085_abnormal_gallbladder_physiolo1.64465413
33MP0003806_abnormal_nucleotide_metabolis1.63362563
34MP0001986_abnormal_taste_sensitivity1.58518414
35MP0003890_abnormal_embryonic-extraembry1.58410063
36MP0008007_abnormal_cellular_replicative1.57037798
37MP0000647_abnormal_sebaceous_gland1.52595236
38MP0008775_abnormal_heart_ventricle1.52511523
39MP0003195_calcinosis1.49055980
40MP0005266_abnormal_metabolism1.45660301
41MP0002064_seizures1.45517747
42MP0001764_abnormal_homeostasis1.44706760
43MP0003279_aneurysm1.43602407
44MP0003186_abnormal_redox_activity1.43402101
45MP0005647_abnormal_sex_gland1.42813448
46MP0005389_reproductive_system_phenotype1.40887438
47MP0002254_reproductive_system_inflammat1.40319841
48MP0006035_abnormal_mitochondrial_morpho1.36039061
49MP0008569_lethality_at_weaning1.35328095
50MP0002733_abnormal_thermal_nociception1.34862657
51MP0002877_abnormal_melanocyte_morpholog1.34190353
52MP0005076_abnormal_cell_differentiation1.33643619
53MP0006054_spinal_hemorrhage1.32780739
54MP0005365_abnormal_bile_salt1.30561687
55MP0004924_abnormal_behavior1.29542979
56MP0005386_behavior/neurological_phenoty1.29542979
57MP0001299_abnormal_eye_distance/1.28663848
58MP0009250_abnormal_appendicular_skeleto1.26356615
59MP0002572_abnormal_emotion/affect_behav1.25244526
60MP0003942_abnormal_urinary_system1.24536703
61MP0010386_abnormal_urinary_bladder1.22929749
62MP0000613_abnormal_salivary_gland1.22305056
63MP0001853_heart_inflammation1.20641546
64MP0005408_hypopigmentation1.20501976
65MP0003879_abnormal_hair_cell1.20162513
66MP0009379_abnormal_foot_pigmentation1.18786468
67MP0001486_abnormal_startle_reflex1.16110341
68MP0001958_emphysema1.15836492
69MP0000467_abnormal_esophagus_morphology1.14599782
70MP0001293_anophthalmia1.13813563
71MP0003567_abnormal_fetal_cardiomyocyte1.10791609
72MP0005084_abnormal_gallbladder_morpholo1.10278428
73MP0001851_eye_inflammation1.09326706
74MP0005075_abnormal_melanosome_morpholog1.08936259
75MP0001529_abnormal_vocalization1.08399492
76MP0005423_abnormal_somatic_nervous1.06928195
77MP0001177_atelectasis1.06061196
78MP0001346_abnormal_lacrimal_gland1.05217399
79MP0008961_abnormal_basal_metabolism1.04323815
80MP0002735_abnormal_chemical_nociception1.02291406
81MP0002098_abnormal_vibrissa_morphology1.01683554
82MP0002133_abnormal_respiratory_system1.00750678
83MP0005388_respiratory_system_phenotype1.00750678
84MP0002734_abnormal_mechanical_nocicepti0.97216589
85MP0002127_abnormal_cardiovascular_syste0.96311879
86MP0003786_premature_aging0.95369043
87MP0001485_abnormal_pinna_reflex0.95251793
88MP0001963_abnormal_hearing_physiology0.95215385
89MP0002090_abnormal_vision0.94567299
90MP0002249_abnormal_larynx_morphology0.94110904
91MP0003937_abnormal_limbs/digits/tail_de0.91755562
92MP0005253_abnormal_eye_physiology0.90351095
93MP0004215_abnormal_myocardial_fiber0.89460841
94MP0009697_abnormal_copulation0.87831047
95MP0005671_abnormal_response_to0.87664689
96MP0000049_abnormal_middle_ear0.87255601
97MP0003122_maternal_imprinting0.87048347
98MP0002160_abnormal_reproductive_system0.86246972
99MP0002095_abnormal_skin_pigmentation0.86126984
100MP0010352_gastrointestinal_tract_polyps0.85319097
101MP0003283_abnormal_digestive_organ0.82792951
102MP0005197_abnormal_uvea_morphology0.82328188
103MP0004264_abnormal_extraembryonic_tissu0.78937807
104MP0003119_abnormal_digestive_system0.77804251
105MP0001905_abnormal_dopamine_level0.75426696
106MP0003121_genomic_imprinting0.75286640
107MP0003959_abnormal_lean_body0.74932601
108MP0002837_dystrophic_cardiac_calcinosis0.74412859
109MP0006036_abnormal_mitochondrial_physio0.73332427
110MP0000026_abnormal_inner_ear0.72431324
111MP0002405_respiratory_system_inflammati0.71375449
112MP0001929_abnormal_gametogenesis0.71241888
113MP0001970_abnormal_pain_threshold0.70624517
114MP0001835_abnormal_antigen_presentation0.70518917
115MP0001501_abnormal_sleep_pattern0.70054630
116MP0002067_abnormal_sensory_capabilities0.69349184
117MP0005410_abnormal_fertilization0.69286376
118MP0005645_abnormal_hypothalamus_physiol0.68774349
119MP0001324_abnormal_eye_pigmentation0.68368254
120MP0003755_abnormal_palate_morphology0.68047517
121MP0002653_abnormal_ependyma_morphology0.68011976
122MP0004859_abnormal_synaptic_plasticity0.67841492
123MP0006276_abnormal_autonomic_nervous0.67610177
124MP0000762_abnormal_tongue_morphology0.67472840
125MP0002229_neurodegeneration0.67329711
126MP0002177_abnormal_outer_ear0.66955835
127MP0008873_increased_physiological_sensi0.65214348
128MP0008872_abnormal_physiological_respon0.65177173
129MP0003075_altered_response_to0.64842006
130MP0000427_abnormal_hair_cycle0.64838228
131MP0002277_abnormal_respiratory_mucosa0.62516173
132MP0001188_hyperpigmentation0.62270088
133MP0005360_urolithiasis0.62047091
134MP0002295_abnormal_pulmonary_circulatio0.61571014
135MP0002006_tumorigenesis0.61288220
136MP0006292_abnormal_olfactory_placode0.60774185
137MP0005535_abnormal_body_temperature0.60607930
138MP0004742_abnormal_vestibular_system0.59038149
139MP0003566_abnormal_cell_adhesion0.58966891
140MP0004185_abnormal_adipocyte_glucose0.58762299
141MP0004134_abnormal_chest_morphology0.57588116
142MP0001849_ear_inflammation0.57492862
143MP0010329_abnormal_lipoprotein_level0.56696543
144MP0002971_abnormal_brown_adipose0.56235122
145MP0002234_abnormal_pharynx_morphology0.53007394
146MP0002272_abnormal_nervous_system0.52700521
147MP0003252_abnormal_bile_duct0.51697331
148MP0001340_abnormal_eyelid_morphology0.50852504
149MP0009840_abnormal_foam_cell0.50224764
150MP0005376_homeostasis/metabolism_phenot0.50214779
151MP0009745_abnormal_behavioral_response0.48494591
152MP0002557_abnormal_social/conspecific_i0.48352746
153MP0004043_abnormal_pH_regulation0.47029359
154MP0000383_abnormal_hair_follicle0.46068547
155MP0003635_abnormal_synaptic_transmissio0.45517262
156MP0003880_abnormal_central_pattern0.44021366
157MP0003935_abnormal_craniofacial_develop0.43238889
158MP0002332_abnormal_exercise_endurance0.42877252
159MP0009765_abnormal_xenobiotic_induced0.42752245
160MP0005595_abnormal_vascular_smooth0.42536846
161MP0005391_vision/eye_phenotype0.41904313
162MP0005166_decreased_susceptibility_to0.41590318
163MP0002932_abnormal_joint_morphology0.40724824
164MP0003300_gastrointestinal_ulcer0.40716946

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)5.62857983
2Periauricular skin pits (HP:0100277)5.45438668
3Preauricular pit (HP:0004467)5.45438668
4Persistence of primary teeth (HP:0006335)5.45249222
5Aplasia involving bones of the extremities (HP:0009825)5.42746992
6Aplasia involving bones of the upper limbs (HP:0009823)5.42746992
7Aplasia of the phalanges of the hand (HP:0009802)5.42746992
8Fibular aplasia (HP:0002990)5.27254766
9Abnormality of the phalanges of the 2nd finger (HP:0009541)5.19275365
10Hypoplasia of the uterus (HP:0000013)5.17553493
11Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)4.60968626
12Methylmalonic acidemia (HP:0002912)4.58750273
13Abnormality of the frontal sinuses (HP:0002687)4.41241741
14Abnormality of the proximal phalanges of the hand (HP:0009834)4.39591585
15Syncope (HP:0001279)4.28356191
16Aplasia/hypoplasia of the uterus (HP:0008684)4.23019122
17Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)4.21064418
18Hyperglycinuria (HP:0003108)4.03691543
19Urinary bladder sphincter dysfunction (HP:0002839)3.99350235
20Homocystinuria (HP:0002156)3.98343618
21Abnormality of homocysteine metabolism (HP:0010919)3.98343618
22Palpitations (HP:0001962)3.92680901
23Popliteal pterygium (HP:0009756)3.89405952
24Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.82807335
25Megaloblastic anemia (HP:0001889)3.72161421
26Abnormal hemoglobin (HP:0011902)3.70108940
27Duplicated collecting system (HP:0000081)3.68918404
28Adactyly (HP:0009776)3.68726088
29Stomatitis (HP:0010280)3.61264612
30Abnormality of the middle phalanges of the toes (HP:0010183)3.61237853
31Skin pits (HP:0100276)3.60182488
32Abnormality of the phalanges of the 5th finger (HP:0004213)3.54186677
33Septate vagina (HP:0001153)3.51170367
34Pancytopenia (HP:0001876)3.43694173
35Abnormality of the 2nd finger (HP:0004100)3.40194639
36Lip pit (HP:0100267)3.34011528
37Abnormality of the renal collecting system (HP:0004742)3.33590992
38Vaginal fistula (HP:0004320)3.32950750
39Methylmalonic aciduria (HP:0012120)3.27824966
40Paralysis (HP:0003470)3.25154741
41Abnormality of glycine metabolism (HP:0010895)3.23321405
42Abnormality of serine family amino acid metabolism (HP:0010894)3.23321405
43Abnormality of methionine metabolism (HP:0010901)3.20025503
44Papillary thyroid carcinoma (HP:0002895)3.16200378
45Ulnar bowing (HP:0003031)3.16057034
46Renal tubular acidosis (HP:0001947)3.12666780
47Bowel incontinence (HP:0002607)3.11428099
48Stomach cancer (HP:0012126)3.10886124
49Congenital, generalized hypertrichosis (HP:0004540)3.08033720
50Labial hypoplasia (HP:0000066)3.05407087
51Abnormal large intestine physiology (HP:0012700)3.04467556
52Abnormal sex determination (HP:0012244)2.97571484
53Sex reversal (HP:0012245)2.97571484
54Hypothermia (HP:0002045)2.96932066
55Hypoplasia of the ulna (HP:0003022)2.95478449
56Abnormality of the vitamin B12 metabolism (HP:0004341)2.94046143
57Urinary urgency (HP:0000012)2.92396771
58Oligodontia (HP:0000677)2.86392633
59Scapular winging (HP:0003691)2.83536682
60Hyperglycinemia (HP:0002154)2.78467199
61Abnormality of the distal phalanges of the toes (HP:0010182)2.77669466
62Abnormality of vitamin B metabolism (HP:0004340)2.75345081
63Pancreatic fibrosis (HP:0100732)2.73425739
64Hypoplastic female external genitalia (HP:0012815)2.73101303
65True hermaphroditism (HP:0010459)2.72825846
66Bilateral sensorineural hearing impairment (HP:0008619)2.72805916
67Brittle hair (HP:0002299)2.71435546
68Renal dysplasia (HP:0000110)2.63613527
69Anal stenosis (HP:0002025)2.63290910
70Short hallux (HP:0010109)2.62817919
71Abolished electroretinogram (ERG) (HP:0000550)2.60891494
72Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.56992537
73Decreased activity of mitochondrial respiratory chain (HP:0008972)2.56992537
74Synostosis involving bones of the feet (HP:0009140)2.56753896
75Synostosis involving bones of the lower limbs (HP:0009138)2.56753896
76Tarsal synostosis (HP:0008368)2.50425054
77Symphalangism affecting the phalanges of the hand (HP:0009773)2.49938139
78Synostosis involving the elbow (HP:0003938)2.48540207
79Humeroradial synostosis (HP:0003041)2.48540207
80Pancreatic cysts (HP:0001737)2.48108259
81Male pseudohermaphroditism (HP:0000037)2.46634321
82Failure to thrive in infancy (HP:0001531)2.44429473
83Aplasia/Hypoplasia of the hallux (HP:0008362)2.43651493
84Micronodular cirrhosis (HP:0001413)2.43264458
85Hepatocellular necrosis (HP:0001404)2.42064097
86Abnormality of aspartate family amino acid metabolism (HP:0010899)2.41570882
87Aplasia/Hypoplasia of the fibula (HP:0006492)2.40300133
88Decreased electroretinogram (ERG) amplitude (HP:0000654)2.39706271
89Chronic hepatic failure (HP:0100626)2.39465690
90Abnormal biliary tract physiology (HP:0012439)2.37075088
91Bile duct proliferation (HP:0001408)2.37075088
92Spastic gait (HP:0002064)2.36857932
93Short femoral neck (HP:0100864)2.34730491
94IgM deficiency (HP:0002850)2.34643839
95Aplasia/Hypoplasia of the ulna (HP:0006495)2.34203481
96Chorioretinal atrophy (HP:0000533)2.33231054
97Hepatic necrosis (HP:0002605)2.32211593
98Bronchomalacia (HP:0002780)2.31105061
99B lymphocytopenia (HP:0010976)2.29819628
100Pigmentary retinal degeneration (HP:0001146)2.28957707
101Abnormality of B cell number (HP:0010975)2.28766745
102Abnormal protein glycosylation (HP:0012346)2.27721310
103Abnormal glycosylation (HP:0012345)2.27721310
104Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.27721310
105Abnormal protein N-linked glycosylation (HP:0012347)2.27721310
106Mitochondrial inheritance (HP:0001427)2.27397251
107Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.25581181
108Abnormality of alanine metabolism (HP:0010916)2.25581181
109Hyperalaninemia (HP:0003348)2.25581181
110Absent thumb (HP:0009777)2.24777664
111Hyperphosphatemia (HP:0002905)2.24061069
112Progressive inability to walk (HP:0002505)2.23360644
113Hypoplastic scapulae (HP:0000882)2.22992079
114Aplasia/Hypoplasia of the scapulae (HP:0006713)2.22992079
115Abnormal number of incisors (HP:0011064)2.22199130
116Hypoplastic labia majora (HP:0000059)2.21292550
117Optic neuritis (HP:0100653)2.20759663
118Retrobulbar optic neuritis (HP:0100654)2.20759663
119Macular degeneration (HP:0000608)2.20511442
120Annular pancreas (HP:0001734)2.20419883
121Limb dystonia (HP:0002451)2.17907843
122Bilateral microphthalmos (HP:0007633)2.16599857
123Progressive cerebellar ataxia (HP:0002073)2.16297550
124Gastrointestinal stroma tumor (HP:0100723)2.15730990
125Acute necrotizing encephalopathy (HP:0006965)2.13994723
126Hepatocellular carcinoma (HP:0001402)2.13956436
127Carpal synostosis (HP:0009702)2.13765094
128Absent eyelashes (HP:0000561)2.13592805
129Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.10468186
130Vascular calcification (HP:0004934)2.08820124
131IgG deficiency (HP:0004315)2.07182098
132Amyloidosis (HP:0011034)2.06827149
133Macrocytic anemia (HP:0001972)2.03246210
134Abnormality of the labia (HP:0000058)2.02589385
135Absent eyebrow (HP:0002223)2.02383028
136Submucous cleft hard palate (HP:0000176)2.01373441
137Gonadal dysgenesis (HP:0000133)2.00409768
138Abnormality of the labia majora (HP:0012881)1.99574573
139Prominent supraorbital ridges (HP:0000336)1.99243603
140Long palpebral fissure (HP:0000637)1.99218830
141Synostosis of carpal bones (HP:0005048)1.98505939
142Pterygium (HP:0001059)1.98080349
143Clonus (HP:0002169)1.97217452
144Septo-optic dysplasia (HP:0100842)1.96344961
145Type I transferrin isoform profile (HP:0003642)1.96035790
146Severe global developmental delay (HP:0011344)1.95758560
147Anomalous pulmonary venous return (HP:0010772)1.94508968
148Neonatal hypoglycemia (HP:0001998)1.93403808
149Cupped ear (HP:0000378)1.90809908
150Thyroid carcinoma (HP:0002890)1.90177011
151Absent toe (HP:0010760)1.89514592
152Renal cortical cysts (HP:0000803)1.89482804
153Rib fusion (HP:0000902)1.88985058
154Long foot (HP:0001833)1.88823808
155Bifid scrotum (HP:0000048)1.88404703
156Sclerocornea (HP:0000647)1.88186179
157Molar tooth sign on MRI (HP:0002419)1.87860487
158Abnormality of midbrain morphology (HP:0002418)1.87860487
159Inability to walk (HP:0002540)1.87701764
160Occipital encephalocele (HP:0002085)1.87403959
161Broad hallux (HP:0010055)1.86589246
162Abnormal pancreas size (HP:0012094)1.86577291
163Female pseudohermaphroditism (HP:0010458)1.86518239
164Hemivertebrae (HP:0002937)1.86315167
165Colon cancer (HP:0003003)1.86125400
166Bowing of the arm (HP:0006488)1.85993450
167Bowed forearm bones (HP:0003956)1.85993450
168Renal tubular dysfunction (HP:0000124)1.85968884
169Confusion (HP:0001289)1.85927074
170Acute encephalopathy (HP:0006846)1.85880784
171Ketosis (HP:0001946)1.85693422
172Neurofibrillary tangles (HP:0002185)1.84969339
173Abnormality of the epiphyses of the hand (HP:0005924)1.84121999
174Median cleft lip (HP:0000161)1.83514062
175Short palpebral fissure (HP:0012745)1.83130660
1763-Methylglutaconic aciduria (HP:0003535)1.83068774
177Severe muscular hypotonia (HP:0006829)1.81842584
178Anhidrosis (HP:0000970)1.80689369
179Abnormality of vitamin metabolism (HP:0100508)1.79973540
180Cerebral inclusion bodies (HP:0100314)1.79920562
181Lipid accumulation in hepatocytes (HP:0006561)1.79340540
182Late onset (HP:0003584)1.78938900
183Abnormality of dental color (HP:0011073)1.78723729
184Large for gestational age (HP:0001520)1.78468728
185Abnormality of serum amino acid levels (HP:0003112)1.77461700
186Increased hepatocellular lipid droplets (HP:0006565)1.77177393
187Abnormality of the pulmonary veins (HP:0011718)1.77064662
188Cardiovascular calcification (HP:0011915)1.76854211
189Degeneration of the lateral corticospinal tracts (HP:0002314)1.76595796
190Chromsome breakage (HP:0040012)1.76258853

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB37.41723878
2VRK24.53912017
3MAP3K24.40403332
4MAPKAPK53.87058628
5MAP3K33.55645401
6CAMKK23.14176453
7MAP4K22.97856086
8CSNK1A1L2.90588718
9NME12.89313976
10MST42.77405637
11TXK2.76865607
12BUB12.41797008
13ARAF2.31867854
14CASK2.26490813
15CSNK1G32.16684677
16PRKD32.08215854
17RPS6KB22.06908499
18EPHA32.04159871
19TSSK62.00228899
20IRAK21.97067715
21CSNK1G21.97053593
22PBK1.96833740
23MAP3K61.96023837
24PRPF4B1.94128056
25MAPK151.85245884
26NUAK11.84419908
27PDK41.81939710
28PDK31.81939710
29ERBB31.77933816
30CAMK1G1.63764611
31PTK2B1.61402598
32STK161.57721000
33CSNK1G11.55908070
34MAP3K91.55132569
35TAOK31.53944907
36EPHB11.49210142
37GRK71.48643471
38PAK31.46847637
39RIPK41.46651207
40ILK1.34004008
41BRAF1.33567150
42LATS21.31750885
43MAP3K111.29986748
44BMPR21.24320886
45STK391.24113024
46CAMK1D1.24088545
47CAMKK11.19067628
48CSF1R1.10087300
49DAPK21.08501698
50MAP3K51.05198492
51TAF10.99378811
52PLK30.96850475
53MELK0.96628225
54ZAK0.96115524
55CDC70.94945654
56PNCK0.94278928
57MAP2K10.93500220
58MAP2K40.92906960
59DYRK20.92228959
60BRSK20.91969754
61TLK10.90651482
62BRSK10.87759655
63PDK20.87720860
64BCR0.85814652
65FRK0.85605507
66CDK190.83938636
67ERBB20.82928390
68EPHA20.82166147
69OXSR10.81893235
70MINK10.80550388
71PRKCE0.79338800
72GRK10.79115499
73ERBB40.77736288
74WEE10.75934247
75PRKCQ0.74856473
76EIF2AK20.74836928
77TYRO30.73249715
78FES0.72906703
79DYRK1A0.71674889
80MAPKAPK30.71589712
81PRKCH0.71525991
82MET0.70889278
83DDR20.69013776
84PDPK10.68686820
85MAP4K10.68420805
86GRK60.66173276
87HIPK20.65960271
88TRPM70.65224631
89BMX0.64122361
90DYRK1B0.63852573
91WNK40.63830355
92WNK30.60861971
93FGFR40.60220363
94JAK10.58190207
95MAP2K30.55606217
96CSNK1A10.55040123
97MARK10.53021153
98TBK10.51976081
99AKT30.51745139
100EPHB20.49792565
101BMPR1B0.49672853
102MAP3K120.49455103
103NTRK30.47944634
104PIM20.47475990
105UHMK10.47455742
106ADRBK20.47296913
107PRKG10.46656789
108WNK10.46442320
109YES10.44218370
110PINK10.44198071
111MAPK130.43916704
112PRKCZ0.42572978
113CAMK2B0.42531174
114FER0.42015658
115PIM10.41580442
116TESK20.41468498
117CDK50.40720250
118EEF2K0.39002607
119VRK10.38433909
120CHEK20.37964128
121ALK0.37822042
122RPS6KB10.37554609
123PRKG20.36975392
124IKBKB0.36884130
125MAP2K20.36586909
126BCKDK0.35676230
127RPS6KA20.35289559
128PRKCI0.34715154
129PLK20.34494787
130MATK0.33502003
131LIMK10.32691035
132PRKACA0.32310027
133CAMK2A0.31833930
134SMG10.31776673
135CAMK2D0.31671731
136PRKAA10.31323841
137PDK10.30128961
138PRKCG0.29945436
139PLK10.29907750
140DAPK10.28873997
141NEK10.28813667
142STK40.28760241
143STK30.28757915
144PRKD20.28309484
145NEK20.27511930
146PTK60.27487647
147NTRK10.23885594
148ADRBK10.20847879
149CSNK1D0.19969297
150MAP3K70.19761348
151PRKD10.18040193
152TIE10.18022264
153CDK180.17682705
154CSNK1E0.17147286
155CDK150.17117730
156ROCK20.17111296
157MAPK140.16576822
158MAP2K70.15987370
159CAMK2G0.15982192
160INSRR0.15527389
161EPHA40.14546894
162MST1R0.14501153
163RET0.14390644
164MAPKAPK20.13873491

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000537.55408218
2Pentose and glucuronate interconversions_Homo sapiens_hsa000406.47977491
3Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.85377930
4Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.76946470
5Drug metabolism - other enzymes_Homo sapiens_hsa009833.75681527
6RNA polymerase_Homo sapiens_hsa030203.74361049
7Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008603.67506908
8Chemical carcinogenesis_Homo sapiens_hsa052043.51142451
9Starch and sucrose metabolism_Homo sapiens_hsa005003.34643219
10Steroid hormone biosynthesis_Homo sapiens_hsa001403.26516521
11Proteasome_Homo sapiens_hsa030503.11909629
12Retinol metabolism_Homo sapiens_hsa008302.85006066
13Vitamin digestion and absorption_Homo sapiens_hsa049772.80830995
14Ribosome_Homo sapiens_hsa030102.62978994
15Basal transcription factors_Homo sapiens_hsa030222.33210043
16Sulfur metabolism_Homo sapiens_hsa009202.24270041
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.10430063
18Cardiac muscle contraction_Homo sapiens_hsa042601.94085897
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.91518502
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.87678077
21Folate biosynthesis_Homo sapiens_hsa007901.84359723
22Caffeine metabolism_Homo sapiens_hsa002321.82408039
23Nitrogen metabolism_Homo sapiens_hsa009101.77848155
24Selenocompound metabolism_Homo sapiens_hsa004501.55698008
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38891115
26Primary immunodeficiency_Homo sapiens_hsa053401.37539674
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26491638
28Mineral absorption_Homo sapiens_hsa049781.26316123
29One carbon pool by folate_Homo sapiens_hsa006701.25484874
30Pyrimidine metabolism_Homo sapiens_hsa002401.24831939
31Fanconi anemia pathway_Homo sapiens_hsa034601.19398185
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.17785380
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17339072
34Propanoate metabolism_Homo sapiens_hsa006401.15760068
35Taste transduction_Homo sapiens_hsa047421.11038931
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09386669
37Collecting duct acid secretion_Homo sapiens_hsa049661.06847758
38Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.06417244
39Amphetamine addiction_Homo sapiens_hsa050311.03145847
40Base excision repair_Homo sapiens_hsa034101.01568404
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01540244
42Spliceosome_Homo sapiens_hsa030400.99813602
43Cocaine addiction_Homo sapiens_hsa050300.98928284
44Nucleotide excision repair_Homo sapiens_hsa034200.98845535
45Purine metabolism_Homo sapiens_hsa002300.94867881
46Intestinal immune network for IgA production_Homo sapiens_hsa046720.93710730
47Phototransduction_Homo sapiens_hsa047440.93336665
48Homologous recombination_Homo sapiens_hsa034400.91571961
49Synaptic vesicle cycle_Homo sapiens_hsa047210.91456408
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90942030
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.90599291
52Cholinergic synapse_Homo sapiens_hsa047250.90046501
53Tyrosine metabolism_Homo sapiens_hsa003500.87960564
54ABC transporters_Homo sapiens_hsa020100.87245808
55Serotonergic synapse_Homo sapiens_hsa047260.87236220
56Renin secretion_Homo sapiens_hsa049240.85971627
57Galactose metabolism_Homo sapiens_hsa000520.84193058
58Sulfur relay system_Homo sapiens_hsa041220.81913548
59N-Glycan biosynthesis_Homo sapiens_hsa005100.80432079
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80123719
61Tight junction_Homo sapiens_hsa045300.80105144
62Glutathione metabolism_Homo sapiens_hsa004800.76397618
63Arachidonic acid metabolism_Homo sapiens_hsa005900.73396223
64Gastric acid secretion_Homo sapiens_hsa049710.73276438
65Morphine addiction_Homo sapiens_hsa050320.72623268
66Metabolic pathways_Homo sapiens_hsa011000.71815130
67Dopaminergic synapse_Homo sapiens_hsa047280.65853507
68Linoleic acid metabolism_Homo sapiens_hsa005910.65161932
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64677067
70Butanoate metabolism_Homo sapiens_hsa006500.63443273
71Mismatch repair_Homo sapiens_hsa034300.62732015
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59453675
73Phagosome_Homo sapiens_hsa041450.59010428
74Prion diseases_Homo sapiens_hsa050200.57877275
75Pyruvate metabolism_Homo sapiens_hsa006200.56851537
76Peroxisome_Homo sapiens_hsa041460.55502950
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55449840
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54574711
79Olfactory transduction_Homo sapiens_hsa047400.53895845
80Vibrio cholerae infection_Homo sapiens_hsa051100.51586298
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.50480397
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48241929
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47112013
84Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46971120
85Oocyte meiosis_Homo sapiens_hsa041140.46471072
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46194569
87Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.46126795
88Sphingolipid metabolism_Homo sapiens_hsa006000.45997194
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44604887
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44181157
91Vitamin B6 metabolism_Homo sapiens_hsa007500.43933734
92Estrogen signaling pathway_Homo sapiens_hsa049150.42692065
93GABAergic synapse_Homo sapiens_hsa047270.42613622
94Insulin secretion_Homo sapiens_hsa049110.41236588
95Glucagon signaling pathway_Homo sapiens_hsa049220.40692365
96Hedgehog signaling pathway_Homo sapiens_hsa043400.40362777
97Thyroid hormone synthesis_Homo sapiens_hsa049180.39021333
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36383947
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36022117
100Ether lipid metabolism_Homo sapiens_hsa005650.35801226
101Oxidative phosphorylation_Homo sapiens_hsa001900.34873152
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34643200
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33571143
104PPAR signaling pathway_Homo sapiens_hsa033200.33403738
105Fatty acid elongation_Homo sapiens_hsa000620.33096158
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33068845
107Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32759183
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32676574
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.31797083
110Steroid biosynthesis_Homo sapiens_hsa001000.31615231
111Bile secretion_Homo sapiens_hsa049760.30173641
112Salivary secretion_Homo sapiens_hsa049700.29738139
113Hippo signaling pathway_Homo sapiens_hsa043900.29733368
114Fat digestion and absorption_Homo sapiens_hsa049750.27853148
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27033104
116* Melanoma_Homo sapiens_hsa052180.25819686
117Adherens junction_Homo sapiens_hsa045200.25818142
118Insulin resistance_Homo sapiens_hsa049310.25571371
119Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.25520542
120Fatty acid metabolism_Homo sapiens_hsa012120.25338113
121Axon guidance_Homo sapiens_hsa043600.25074660
122RNA degradation_Homo sapiens_hsa030180.24951752
123Arginine biosynthesis_Homo sapiens_hsa002200.24543375
124Protein export_Homo sapiens_hsa030600.23807871
125Rheumatoid arthritis_Homo sapiens_hsa053230.23745963
126cGMP-PKG signaling pathway_Homo sapiens_hsa040220.23574102
127Dilated cardiomyopathy_Homo sapiens_hsa054140.22695301
128Ovarian steroidogenesis_Homo sapiens_hsa049130.20882961
129Nicotine addiction_Homo sapiens_hsa050330.17938376
130Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.17827645
131Influenza A_Homo sapiens_hsa051640.17553537
132Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.17530286
133Phenylalanine metabolism_Homo sapiens_hsa003600.17511015
134Melanogenesis_Homo sapiens_hsa049160.17497873
135Adipocytokine signaling pathway_Homo sapiens_hsa049200.17163687
136ECM-receptor interaction_Homo sapiens_hsa045120.17115178
137Wnt signaling pathway_Homo sapiens_hsa043100.16462738
138Alzheimers disease_Homo sapiens_hsa050100.16430221
139Tuberculosis_Homo sapiens_hsa051520.14754914
140cAMP signaling pathway_Homo sapiens_hsa040240.13855862
141Parkinsons disease_Homo sapiens_hsa050120.12503735
142Type II diabetes mellitus_Homo sapiens_hsa049300.12452942
143Hepatitis C_Homo sapiens_hsa051600.12429753
144Circadian entrainment_Homo sapiens_hsa047130.12335930
145Tryptophan metabolism_Homo sapiens_hsa003800.12088896
146African trypanosomiasis_Homo sapiens_hsa051430.11843432
147Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.11577297
148Calcium signaling pathway_Homo sapiens_hsa040200.09524484
149Basal cell carcinoma_Homo sapiens_hsa052170.09167859
150Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.08834424
151Proteoglycans in cancer_Homo sapiens_hsa052050.08764787
152Prostate cancer_Homo sapiens_hsa052150.08727653
153Glutamatergic synapse_Homo sapiens_hsa047240.08460194
154Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.08020988
155Notch signaling pathway_Homo sapiens_hsa043300.07824062
156Huntingtons disease_Homo sapiens_hsa050160.07524265
157Focal adhesion_Homo sapiens_hsa045100.07034166

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