FGF21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Theis gene encodes a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. This protein is a secreted endocrine factor that functions as a major metabolic regulator. The encoded protein stimulates the uptake of glucose in adipose tissue. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glyoxylate metabolic process (GO:0046487)8.70784997
2positive regulation of Cdc42 GTPase activity (GO:0043089)8.65590593
3negative regulation of fibrinolysis (GO:0051918)8.28365671
4regulation of fibrinolysis (GO:0051917)8.14030631
5regulation of T-helper 1 cell differentiation (GO:0045625)8.07108807
6regulation of protein activation cascade (GO:2000257)8.00869287
7complement activation, alternative pathway (GO:0006957)7.97793296
8positive regulation of antigen processing and presentation (GO:0002579)7.45458986
9regulation of complement activation (GO:0030449)7.38744085
10drug catabolic process (GO:0042737)6.92633722
11positive regulation of granulocyte chemotaxis (GO:0071624)6.80003851
12fibrinolysis (GO:0042730)6.73117143
13protein carboxylation (GO:0018214)6.60010074
14peptidyl-glutamic acid carboxylation (GO:0017187)6.60010074
15erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.55806112
16L-phenylalanine catabolic process (GO:0006559)6.55806112
17cellular glucuronidation (GO:0052695)6.34998830
18negative regulation of sterol transport (GO:0032372)6.23300445
19negative regulation of cholesterol transport (GO:0032375)6.23300445
20serine family amino acid catabolic process (GO:0009071)6.22218578
21regulation of antigen processing and presentation (GO:0002577)6.19646937
22positive regulation of interleukin-8 biosynthetic process (GO:0045416)6.13799469
23L-phenylalanine metabolic process (GO:0006558)6.13220748
24erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.13220748
25myeloid dendritic cell differentiation (GO:0043011)6.10461098
26uronic acid metabolic process (GO:0006063)6.06679716
27glucuronate metabolic process (GO:0019585)6.06679716
28glycine metabolic process (GO:0006544)6.04411040
29regulation of triglyceride catabolic process (GO:0010896)6.04283962
30tongue development (GO:0043586)5.98290724
31blood coagulation, intrinsic pathway (GO:0007597)5.95755517
32serine family amino acid biosynthetic process (GO:0009070)5.93029533
33peptide catabolic process (GO:0043171)5.86109694
34dendritic cell differentiation (GO:0097028)5.83093130
35positive regulation of T-helper 1 type immune response (GO:0002827)5.78064546
36exogenous drug catabolic process (GO:0042738)5.76841712
37NIK/NF-kappaB signaling (GO:0038061)5.75104854
38negative regulation of interleukin-10 production (GO:0032693)5.74781338
39phospholipid efflux (GO:0033700)5.69884008
40phenylpropanoid metabolic process (GO:0009698)5.57749019
41oxidative demethylation (GO:0070989)5.54684127
42L-serine metabolic process (GO:0006563)5.52178633
43pericardium development (GO:0060039)5.52023151
44oxygen transport (GO:0015671)5.50935149
45positive regulation of glycoprotein biosynthetic process (GO:0010560)5.50107966
46positive regulation of T-helper cell differentiation (GO:0045624)5.43780775
47regulation of plasminogen activation (GO:0010755)5.41316334
48regulation of cholesterol esterification (GO:0010872)5.38888454
49positive regulation of neutrophil chemotaxis (GO:0090023)5.30651902
50positive regulation of neutrophil migration (GO:1902624)5.30651902
51serine family amino acid metabolic process (GO:0009069)5.29224839
52negative regulation of protein activation cascade (GO:2000258)5.20455837
53epoxygenase P450 pathway (GO:0019373)5.17269261
54response to nitric oxide (GO:0071731)5.12269389
55regulation of Cdc42 GTPase activity (GO:0043088)5.05079294
56hormone catabolic process (GO:0042447)5.04318862
57negative regulation of hemostasis (GO:1900047)5.03590455
58negative regulation of blood coagulation (GO:0030195)5.03590455
59bile acid biosynthetic process (GO:0006699)5.00906755
60myeloid dendritic cell activation (GO:0001773)4.97923329
61cysteine metabolic process (GO:0006534)4.90941053
62positive regulation of interleukin-1 beta secretion (GO:0050718)4.86172471
63response to prostaglandin E (GO:0034695)4.84836454
64acylglycerol homeostasis (GO:0055090)4.83070909
65triglyceride homeostasis (GO:0070328)4.83070909
66dendritic cell chemotaxis (GO:0002407)4.80242424
67protein activation cascade (GO:0072376)4.80196630
68triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.79854374
69superoxide anion generation (GO:0042554)4.79274496
70very-low-density lipoprotein particle assembly (GO:0034379)4.72309974
71hydrogen peroxide catabolic process (GO:0042744)4.69683624
72negative regulation of wound healing (GO:0061045)4.68558923
73omega-hydroxylase P450 pathway (GO:0097267)4.67905221
74bile acid metabolic process (GO:0008206)4.65963692
75heme transport (GO:0015886)4.64967331
76negative regulation of lipase activity (GO:0060192)4.64436853
77acute-phase response (GO:0006953)4.62883255
78negative regulation of fatty acid biosynthetic process (GO:0045717)4.61137709
79neurotransmitter catabolic process (GO:0042135)4.59148619
80biotin metabolic process (GO:0006768)4.58209057
81positive regulation of interleukin-1 secretion (GO:0050716)4.57521717
82positive regulation of glycoprotein metabolic process (GO:1903020)4.56993351
83negative regulation of coagulation (GO:0050819)4.56179391
84drug metabolic process (GO:0017144)4.53480335
85high-density lipoprotein particle remodeling (GO:0034375)4.51070812
86plasma lipoprotein particle remodeling (GO:0034369)4.50291814
87protein-lipid complex remodeling (GO:0034368)4.50291814
88macromolecular complex remodeling (GO:0034367)4.50291814
89ventricular cardiac muscle cell development (GO:0055015)4.49119688
90complement activation (GO:0006956)4.48066845
91regulation of humoral immune response (GO:0002920)4.47081744
92renal absorption (GO:0070293)4.42543439
93aromatic amino acid family catabolic process (GO:0009074)4.39914541
94detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)4.39475908
95bile acid and bile salt transport (GO:0015721)4.39021183
96positive regulation of lipoprotein lipase activity (GO:0051006)4.38740234
97positive regulation of triglyceride lipase activity (GO:0061365)4.38740234
98regulation of interleukin-1 beta secretion (GO:0050706)4.37161017
99negative regulation of complement activation (GO:0045916)4.34565261
100positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)4.31831003
101leukotriene biosynthetic process (GO:0019370)4.26685117
102regulation of granulocyte chemotaxis (GO:0071622)4.26144008
103sulfur amino acid catabolic process (GO:0000098)4.20359315
104daunorubicin metabolic process (GO:0044597)4.19571382
105polyketide metabolic process (GO:0030638)4.19571382
106doxorubicin metabolic process (GO:0044598)4.19571382
107complement activation, classical pathway (GO:0006958)4.19306954
108positive regulation of hemostasis (GO:1900048)4.18865163
109positive regulation of blood coagulation (GO:0030194)4.18865163
110* regulation of lipoprotein particle clearance (GO:0010984)4.13673056
111regulation of T-helper 1 type immune response (GO:0002825)4.03855733
112regulation of interleukin-1 secretion (GO:0050704)3.98112183
113plasma lipoprotein particle clearance (GO:0034381)3.95864796
114positive regulation of interleukin-1 production (GO:0032732)3.92956168
115amino-acid betaine metabolic process (GO:0006577)3.92574041
116nitric oxide biosynthetic process (GO:0006809)3.88784380
117steroid catabolic process (GO:0006706)3.88231680
118positive regulation of interleukin-1 beta production (GO:0032731)3.86389929
119cholesterol efflux (GO:0033344)3.85898228
120regulation of neutrophil migration (GO:1902622)3.85866360
121regulation of neutrophil chemotaxis (GO:0090022)3.85866360
122pharyngeal system development (GO:0060037)3.84385295
123positive regulation of coagulation (GO:0050820)3.84337639
124regulation of interleukin-8 biosynthetic process (GO:0045414)3.82896293
125positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.82025065
126synaptic transmission, cholinergic (GO:0007271)3.77936352
127acute inflammatory response (GO:0002526)3.76946930
128amine biosynthetic process (GO:0009309)3.76099749
129cellular biogenic amine biosynthetic process (GO:0042401)3.76099749
130response to prostaglandin (GO:0034694)3.75813185
131reverse cholesterol transport (GO:0043691)3.74485971
132aminoglycoside antibiotic metabolic process (GO:0030647)3.71812665
133regulation of T-helper cell differentiation (GO:0045622)3.71609626
134arginine metabolic process (GO:0006525)3.70160839
135positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.70033398
136cellular response to ATP (GO:0071318)3.69958982
137embryonic digestive tract development (GO:0048566)3.66150565
138ethanol oxidation (GO:0006069)3.65464226
139positive regulation of DNA-templated transcription, initiation (GO:2000144)3.64989104
140proline metabolic process (GO:0006560)3.64718550
141bundle of His cell to Purkinje myocyte communication (GO:0086069)3.62574458
142positive regulation of growth hormone secretion (GO:0060124)3.61193235
143S-adenosylmethionine metabolic process (GO:0046500)3.58274149
144lung vasculature development (GO:0060426)3.57421673
145plasma lipoprotein particle assembly (GO:0034377)3.57180562
146eosinophil migration (GO:0072677)3.57014889
147fat-soluble vitamin biosynthetic process (GO:0042362)3.56957275
148urea metabolic process (GO:0019627)3.55509489
149urea cycle (GO:0000050)3.55509489
150alpha-amino acid catabolic process (GO:1901606)3.49135103
151hypothalamus development (GO:0021854)3.48932052
152primary alcohol catabolic process (GO:0034310)3.48572019
153embryonic heart tube development (GO:0035050)3.47974929
154drug transmembrane transport (GO:0006855)3.47095414
155cytolysis (GO:0019835)3.46873949
156positive regulation of fatty acid biosynthetic process (GO:0045723)3.41527554
157leukotriene metabolic process (GO:0006691)3.41378335
158positive regulation of lipid catabolic process (GO:0050996)3.41012515
159aldehyde catabolic process (GO:0046185)3.40220909
160positive regulation of NF-kappaB import into nucleus (GO:0042346)3.39403153
161growth hormone secretion (GO:0030252)3.38448812
162negative regulation of fatty acid metabolic process (GO:0045922)3.36123782
163positive regulation of response to tumor cell (GO:0002836)3.35772920
164hydrogen peroxide metabolic process (GO:0042743)3.33064033
165positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)3.28859502
166maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.28434793
167glutathione biosynthetic process (GO:0006750)3.28166897
168regulation of phospholipase A2 activity (GO:0032429)3.25885724
169dendritic cell migration (GO:0036336)3.25334646
170positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.20949053
171striated muscle atrophy (GO:0014891)3.20554692
172nitrogen cycle metabolic process (GO:0071941)3.18091581
173regulation of activation of Janus kinase activity (GO:0010533)3.12671720
174diaphragm development (GO:0060539)3.12664955
175head development (GO:0060322)3.06048795
176positive regulation of interleukin-12 production (GO:0032735)3.04815532
177lung epithelium development (GO:0060428)3.04750950
178alkaloid metabolic process (GO:0009820)3.01123108
179nonribosomal peptide biosynthetic process (GO:0019184)2.97630214
180positive regulation of interleukin-4 production (GO:0032753)2.96161890
181vitamin transmembrane transport (GO:0035461)2.96085465
182regulation of RIG-I signaling pathway (GO:0039535)2.95704154
183activation of Rac GTPase activity (GO:0032863)2.94004223
184fucose catabolic process (GO:0019317)2.91643374
185L-fucose metabolic process (GO:0042354)2.91643374
186L-fucose catabolic process (GO:0042355)2.91643374
187gas transport (GO:0015669)2.91361794
188antigen processing and presentation of endogenous antigen (GO:0019883)2.89506682
189protein retention in ER lumen (GO:0006621)2.86822219
190positive regulation of monocyte chemotaxis (GO:0090026)2.82776794
191skeletal muscle organ development (GO:0060538)2.82089159
192intestinal cholesterol absorption (GO:0030299)2.81965374
193auditory behavior (GO:0031223)2.79863515
194programmed necrotic cell death (GO:0097300)2.77556905
195imidazole-containing compound metabolic process (GO:0052803)11.0963648
196regulation of dendritic cell antigen processing and presentation (GO:0002604)10.9940244

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.93486420
2* CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.60851738
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.18347335
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.06049578
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.05351464
6VDR_22108803_ChIP-Seq_LS180_Human2.82579784
7HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.77528190
8RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.41318053
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.38772309
10VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.22825903
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.15160024
12* RXR_22158963_ChIP-Seq_LIVER_Mouse2.03843822
13DROSHA_22980978_ChIP-Seq_HELA_Human2.02484702
14IRF8_22096565_ChIP-ChIP_GC-B_Human1.96583781
15ESR1_15608294_ChIP-ChIP_MCF-7_Human1.96452512
16PPARA_22158963_ChIP-Seq_LIVER_Mouse1.96081247
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.95949291
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95640623
19HNF4A_19822575_ChIP-Seq_HepG2_Human1.95473744
20TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.92328861
21LXR_22158963_ChIP-Seq_LIVER_Mouse1.83109187
22GATA1_22025678_ChIP-Seq_K562_Human1.80153524
23ESR1_21235772_ChIP-Seq_MCF-7_Human1.73836493
24FOXO3_23340844_ChIP-Seq_DLD1_Human1.73169211
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71309821
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.68036265
27FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.64614510
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.61791770
29JARID2_20064375_ChIP-Seq_MESCs_Mouse1.59683225
30ETV2_25802403_ChIP-Seq_MESCs_Mouse1.58540043
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.57711296
32IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.57372145
33CBP_20019798_ChIP-Seq_JUKART_Human1.57372145
34STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.57244876
35STAT1_17558387_ChIP-Seq_HELA_Human1.56592640
36JARID2_20075857_ChIP-Seq_MESCs_Mouse1.54836129
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.54090599
38EGR1_19032775_ChIP-ChIP_M12_Human1.53231701
39E2F7_22180533_ChIP-Seq_HELA_Human1.52022118
40FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.48889441
41IGF1R_20145208_ChIP-Seq_DFB_Human1.48101372
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.46778808
43SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.46724739
44BCAT_22108803_ChIP-Seq_LS180_Human1.46134401
45SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.45814844
46MYC_18555785_ChIP-Seq_MESCs_Mouse1.42121587
47ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.40211395
48IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.38320506
49RNF2_18974828_ChIP-Seq_MESCs_Mouse1.36379843
50EZH2_18974828_ChIP-Seq_MESCs_Mouse1.36379843
51SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.36133419
52EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.36109349
53IRF8_27001747_Chip-Seq_BMDM_Mouse1.35023063
54P53_22127205_ChIP-Seq_FIBROBLAST_Human1.33249595
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32423166
56SOX2_20726797_ChIP-Seq_SW620_Human1.30986567
57VDR_24787735_ChIP-Seq_THP-1_Human1.29338671
58* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.28626803
59NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26676054
60TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.25341849
61TRIM28_21343339_ChIP-Seq_HEK293_Human1.24916955
62ESR1_20079471_ChIP-ChIP_T-47D_Human1.24848636
63ELK4_26923725_Chip-Seq_MESODERM_Mouse1.24552563
64HTT_18923047_ChIP-ChIP_STHdh_Human1.23380483
65SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.23317504
66RAD21_21589869_ChIP-Seq_MESCs_Mouse1.23137375
67MTF2_20144788_ChIP-Seq_MESCs_Mouse1.23029222
68GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.18187221
69NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.17554356
70KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.15840895
71SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.15712981
72EED_16625203_ChIP-ChIP_MESCs_Mouse1.14554400
73RNF2_27304074_Chip-Seq_ESCs_Mouse1.14107475
74GATA6_21074721_ChIP-Seq_CACO-2_Human1.12056599
75FOXA2_19822575_ChIP-Seq_HepG2_Human1.11457806
76PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.09712234
77RXRA_24833708_ChIP-Seq_LIVER_Mouse1.09624653
78GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09558029
79TAF15_26573619_Chip-Seq_HEK293_Human1.09330790
80CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.08980250
81CDX2_22108803_ChIP-Seq_LS180_Human1.08875742
82ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06518952
83ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06494449
84SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.05348201
85ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.04993785
86NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02316286
87BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98781190
88PIAS1_25552417_ChIP-Seq_VCAP_Human0.98023385
89EZH2_27294783_Chip-Seq_ESCs_Mouse0.97858099
90SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.97409045
91MYC_18358816_ChIP-ChIP_MESCs_Mouse0.96989049
92HNFA_21074721_ChIP-Seq_CACO-2_Human0.96767799
93PHF8_20622853_ChIP-Seq_HELA_Human0.96753792
94GATA6_25053715_ChIP-Seq_YYC3_Human0.95864875
95STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.95295544
96TP53_18474530_ChIP-ChIP_U2OS_Human0.95203087
97TP53_20018659_ChIP-ChIP_R1E_Mouse0.94382902
98SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93584264
99CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.90862307
100PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90038815
101ERG_20517297_ChIP-Seq_VCAP_Human0.89921930
102TCF4_18268006_ChIP-ChIP_LS174T_Human0.89596185
103EZH2_27304074_Chip-Seq_ESCs_Mouse0.88552237
104PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.87691280
105NR3C1_23031785_ChIP-Seq_PC12_Mouse0.87147778
106AR_21909140_ChIP-Seq_LNCAP_Human0.86487798
107STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.85761461
108AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.85521730
109SRY_22984422_ChIP-ChIP_TESTIS_Rat0.84414772
110EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.84077058
111MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83666838
112CEBPB_22108803_ChIP-Seq_LS180_Human0.83534423
113PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.83362150
114CREB1_15753290_ChIP-ChIP_HEK293T_Human0.82946744
115E2F1_18555785_ChIP-Seq_MESCs_Mouse0.82710570
116TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.82576310
117IRF1_19129219_ChIP-ChIP_H3396_Human0.82209826
118ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.82043377
119ER_23166858_ChIP-Seq_MCF-7_Human0.82042515
120* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.81823290
121MYC_27129775_Chip-Seq_CORNEA_Mouse0.81659562
122GATA4_25053715_ChIP-Seq_YYC3_Human0.80746634
123PCGF2_27294783_Chip-Seq_ESCs_Mouse0.80465976
124BMI1_23680149_ChIP-Seq_NPCS_Mouse0.80458497
125SA1_27219007_Chip-Seq_Bcells_Human0.80457487
126EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.80087408
127PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.79643047
128LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.79385171
129RXR_22108803_ChIP-Seq_LS180_Human0.78331699
130CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.78103010
131SOX2_21211035_ChIP-Seq_LN229_Human0.77841765
132PPAR_26484153_Chip-Seq_NCI-H1993_Human0.77379300
133SOX2_18692474_ChIP-Seq_MEFs_Mouse0.77265418
134POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.77238775
135P63_26484246_Chip-Seq_KERATINOCYTES_Human0.77209061
136HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.75631586
137NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.75583964
138DNAJC2_21179169_ChIP-ChIP_NT2_Human0.75275411
139SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.75009113
140CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74571042
141MYC_19030024_ChIP-ChIP_MESCs_Mouse0.74397603
142P53_21459846_ChIP-Seq_SAOS-2_Human0.74377167
143FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.74026726
144NFE2_27457419_Chip-Seq_LIVER_Mouse0.73936641
145FOXM1_26456572_ChIP-Seq_MCF-7_Human0.73032636
146STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.72913833
147PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.72566494
148LXR_22292898_ChIP-Seq_THP-1_Human0.72496632
149NFYA_21822215_ChIP-Seq_K562_Human0.72477301
150SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.69302582
151CBX2_22325352_ChIP-Seq_293T-Rex_Human0.69140085
152RBPJ_21746931_ChIP-Seq_IB4_Human0.69125133
153NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.68105414
154GATA3_21867929_ChIP-Seq_CD8_Mouse0.67917900
155BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.67806604
156DCP1A_22483619_ChIP-Seq_HELA_Human0.64535747
157MYC_19079543_ChIP-ChIP_MESCs_Mouse0.64191962
158FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.62572393
159SOX17_20123909_ChIP-Seq_XEN_Mouse0.62233496
160JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.62221396
161FOXA1_25552417_ChIP-Seq_VCAP_Human0.60496825
162OCT4_18692474_ChIP-Seq_MEFs_Mouse0.60217345
163XRN2_22483619_ChIP-Seq_HELA_Human0.59518391
164AR_20517297_ChIP-Seq_VCAP_Human0.59403436
165ZNF263_19887448_ChIP-Seq_K562_Human0.59274276
166NELFA_20434984_ChIP-Seq_ESCs_Mouse0.58820419
167SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.57653081
168NFYB_21822215_ChIP-Seq_K562_Human0.57413531
169PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.56461444
170* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.56457199
171SOX2_18692474_ChIP-Seq_MESCs_Mouse0.56146722
172NANOG_18555785_ChIP-Seq_MESCs_Mouse0.55159283
173ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.54798891
174CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.54135358
175ZFX_18555785_ChIP-Seq_MESCs_Mouse0.54022849
176RAC3_21632823_ChIP-Seq_H3396_Human0.53589403
177BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.53566788
178POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.53172511

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat8.58105996
2MP0002876_abnormal_thyroid_physiology8.05848701
3MP0000685_abnormal_immune_system5.44224721
4MP0001348_abnormal_lacrimal_gland4.58175750
5MP0001346_abnormal_lacrimal_gland4.34234861
6MP0008875_abnormal_xenobiotic_pharmacok4.22131455
7MP0004510_myositis3.89769129
8MP0003252_abnormal_bile_duct3.71866730
9MP0001835_abnormal_antigen_presentation3.65418033
10MP0002877_abnormal_melanocyte_morpholog3.60590443
11MP0009697_abnormal_copulation3.39451815
12MP0003879_abnormal_hair_cell3.18152656
13MP0005310_abnormal_salivary_gland3.04417342
14MP0009840_abnormal_foam_cell3.03393935
15MP0001873_stomach_inflammation2.76598511
16MP0010329_abnormal_lipoprotein_level2.37328861
17MP0002735_abnormal_chemical_nociception2.26087187
18MP0006082_CNS_inflammation2.12117202
19MP0005671_abnormal_response_to2.06003317
20MP0000566_synostosis1.89243899
21MP0005083_abnormal_biliary_tract1.88625176
22MP0003868_abnormal_feces_composition1.87731247
23* MP0001764_abnormal_homeostasis1.85575593
24MP0005647_abnormal_sex_gland1.80885777
25* MP0000609_abnormal_liver_physiology1.79541518
26MP0002138_abnormal_hepatobiliary_system1.63267496
27MP0005085_abnormal_gallbladder_physiolo1.59593196
28MP0003638_abnormal_response/metabolism_1.55667248
29MP0005408_hypopigmentation1.54612402
30MP0004019_abnormal_vitamin_homeostasis1.48475296
31MP0005365_abnormal_bile_salt1.47970730
32MP0001661_extended_life_span1.47491876
33MP0003186_abnormal_redox_activity1.44774073
34MP0001853_heart_inflammation1.44106472
35MP0001666_abnormal_nutrient_absorption1.37547700
36MP0001501_abnormal_sleep_pattern1.34515516
37MP0000470_abnormal_stomach_morphology1.28588559
38MP0003191_abnormal_cellular_cholesterol1.26340272
39MP0009053_abnormal_anal_canal1.23449641
40* MP0003959_abnormal_lean_body1.14994021
41MP0000613_abnormal_salivary_gland1.14850855
42MP0003011_delayed_dark_adaptation1.12467720
43MP0001542_abnormal_bone_strength1.08979191
44MP0005187_abnormal_penis_morphology1.08534589
45* MP0000598_abnormal_liver_morphology1.04968489
46MP0005387_immune_system_phenotype1.02622128
47MP0001790_abnormal_immune_system1.02622128
48MP0003763_abnormal_thymus_physiology1.00295367
49MP0002277_abnormal_respiratory_mucosa0.99468238
50MP0002693_abnormal_pancreas_physiology0.98801013
51MP0003806_abnormal_nucleotide_metabolis0.98102914
52MP0005584_abnormal_enzyme/coenzyme_acti0.96636656
53MP0009765_abnormal_xenobiotic_induced0.94432548
54MP0002160_abnormal_reproductive_system0.93644601
55MP0000604_amyloidosis0.93406228
56MP0009764_decreased_sensitivity_to0.91716854
57MP0005025_abnormal_response_to0.90963893
58MP0005332_abnormal_amino_acid0.90290690
59MP0003453_abnormal_keratinocyte_physiol0.89569032
60MP0003705_abnormal_hypodermis_morpholog0.88555043
61MP0010386_abnormal_urinary_bladder0.88038761
62MP0002734_abnormal_mechanical_nocicepti0.86734370
63MP0001299_abnormal_eye_distance/0.85665823
64MP0002148_abnormal_hypersensitivity_rea0.84795790
65MP0001915_intracranial_hemorrhage0.84647042
66MP0004134_abnormal_chest_morphology0.83825483
67MP0005448_abnormal_energy_balance0.83496889
68* MP0009642_abnormal_blood_homeostasis0.83257428
69MP0000579_abnormal_nail_morphology0.82636110
70MP0005395_other_phenotype0.82110114
71MP0003183_abnormal_peptide_metabolism0.81866737
72MP0000681_abnormal_thyroid_gland0.80707766
73MP0001881_abnormal_mammary_gland0.80125017
74MP0005220_abnormal_exocrine_pancreas0.79121013
75MP0002405_respiratory_system_inflammati0.79052161
76* MP0005376_homeostasis/metabolism_phenot0.78673613
77MP0008872_abnormal_physiological_respon0.78589072
78MP0005636_abnormal_mineral_homeostasis0.77824975
79MP0000538_abnormal_urinary_bladder0.77369631
80MP0000383_abnormal_hair_follicle0.77180883
81MP0001845_abnormal_inflammatory_respons0.76945097
82MP0010352_gastrointestinal_tract_polyps0.76160332
83MP0004270_analgesia0.75896975
84MP0002139_abnormal_hepatobiliary_system0.75253513
85MP0002009_preneoplasia0.74402802
86MP0001800_abnormal_humoral_immune0.74241135
87MP0009643_abnormal_urine_homeostasis0.74007600
88MP0002733_abnormal_thermal_nociception0.73233342
89* MP0005645_abnormal_hypothalamus_physiol0.72886747
90MP0009333_abnormal_splenocyte_physiolog0.69466693
91MP0001243_abnormal_dermal_layer0.68954919
92MP0009785_altered_susceptibility_to0.68504185
93MP0010155_abnormal_intestine_physiology0.67370340
94MP0005000_abnormal_immune_tolerance0.66352453
95MP0002928_abnormal_bile_duct0.63766516
96MP0000427_abnormal_hair_cycle0.63503921
97MP0001851_eye_inflammation0.62640924
98MP0003195_calcinosis0.62576011
99MP0009763_increased_sensitivity_to0.61325743
100MP0003718_maternal_effect0.60745267
101MP0006036_abnormal_mitochondrial_physio0.60199007
102MP0010678_abnormal_skin_adnexa0.59668326
103MP0005360_urolithiasis0.57522402
104MP0004233_abnormal_muscle_weight0.57007499
105MP0008469_abnormal_protein_level0.56140602
106MP0008569_lethality_at_weaning0.55701277
107MP0002638_abnormal_pupillary_reflex0.55536605
108MP0004272_abnormal_basement_membrane0.55193670
109MP0004782_abnormal_surfactant_physiolog0.54607633
110MP0000733_abnormal_muscle_development0.54113805
111MP0001663_abnormal_digestive_system0.52412564
112* MP0002971_abnormal_brown_adipose0.50334807
113MP0002419_abnormal_innate_immunity0.49557093
114MP0008789_abnormal_olfactory_epithelium0.49022177
115MP0001756_abnormal_urination0.48914240
116MP0005451_abnormal_body_composition0.48177964
117MP0005670_abnormal_white_adipose0.47500770
118MP0002697_abnormal_eye_size0.46079503
119MP0001970_abnormal_pain_threshold0.45433593
120MP0006035_abnormal_mitochondrial_morpho0.44549950
121MP0005084_abnormal_gallbladder_morpholo0.44519417
122MP0009672_abnormal_birth_weight0.44449291
123MP0002452_abnormal_antigen_presenting0.44413139
124MP0005319_abnormal_enzyme/_coenzyme0.44380163
125* MP0002078_abnormal_glucose_homeostasis0.43768109
126MP0001485_abnormal_pinna_reflex0.43037220
127MP0002249_abnormal_larynx_morphology0.42547357
128* MP0002118_abnormal_lipid_homeostasis0.41629322
129MP0006138_congestive_heart_failure0.41580217
130MP0005058_abnormal_lysosome_morphology0.41339816
131MP0009780_abnormal_chondrocyte_physiolo0.41326330
132MP0005197_abnormal_uvea_morphology0.41269626
133MP0002269_muscular_atrophy0.41171663
134MP0002723_abnormal_immune_serum0.41011521
135MP0005646_abnormal_pituitary_gland0.40121606
136MP0003567_abnormal_fetal_cardiomyocyte0.39771869
137MP0002168_other_aberrant_phenotype0.39576756
138MP0002796_impaired_skin_barrier0.39479476
139MP0001819_abnormal_immune_cell0.38653009
140MP0002420_abnormal_adaptive_immunity0.38274922
141MP0005535_abnormal_body_temperature0.37969089
142MP0008873_increased_physiological_sensi0.37893037
143MP0005164_abnormal_response_to0.37734661
144MP0000467_abnormal_esophagus_morphology0.37638112
145MP0002132_abnormal_respiratory_system0.36624561
146MP0010368_abnormal_lymphatic_system0.35713219
147MP0005410_abnormal_fertilization0.35524038
148MP0002089_abnormal_postnatal_growth/wei0.35292466
149MP0005266_abnormal_metabolism0.35069996
150MP0002136_abnormal_kidney_physiology0.34337017
151MP0003941_abnormal_skin_development0.33826927
152MP0003690_abnormal_glial_cell0.33693709
153MP0005464_abnormal_platelet_physiology0.33517113
154MP0002282_abnormal_trachea_morphology0.33118278
155MP0003656_abnormal_erythrocyte_physiolo0.32891651
156MP0003699_abnormal_female_reproductive0.31406984
157MP0005377_hearing/vestibular/ear_phenot0.31151827
158MP0003878_abnormal_ear_physiology0.31151827
159MP0003693_abnormal_embryo_hatching0.31148076
160MP0005023_abnormal_wound_healing0.29197192
161MP0000367_abnormal_coat/_hair0.27420644
162MP0001944_abnormal_pancreas_morphology0.27189343
163* MP0002970_abnormal_white_adipose0.26617133
164* MP0003953_abnormal_hormone_level0.25650042
165MP0000249_abnormal_blood_vessel0.24345618
166* MP0005334_abnormal_fat_pad0.24097260
167MP0002090_abnormal_vision0.22945196
168MP0002161_abnormal_fertility/fecundity0.22279688

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)9.91012482
2Abnormality of monocarboxylic acid metabolism (HP:0010996)9.67140773
3Prolonged partial thromboplastin time (HP:0003645)8.07020648
4Hypobetalipoproteinemia (HP:0003563)7.69531562
5Complement deficiency (HP:0004431)7.63916881
6Abnormality of aromatic amino acid family metabolism (HP:0004338)6.86556223
7Congenital malformation of the right heart (HP:0011723)6.79298160
8Double outlet right ventricle (HP:0001719)6.79298160
9Abnormality of complement system (HP:0005339)6.09935200
10Type I diabetes mellitus (HP:0100651)5.93617052
11Abnormality of pyrimidine metabolism (HP:0004353)5.71348667
12Glomerulonephritis (HP:0000099)5.62349108
13Recurrent cutaneous fungal infections (HP:0011370)5.51313335
14Chronic mucocutaneous candidiasis (HP:0002728)5.51313335
15Abnormality of the common coagulation pathway (HP:0010990)5.48719059
16Aplasia/Hypoplasia of the spleen (HP:0010451)5.48195844
17Joint hemorrhage (HP:0005261)5.40062285
18Type 2 muscle fiber atrophy (HP:0003554)5.34512403
19Systemic lupus erythematosus (HP:0002725)5.13961329
20Upper limb muscle weakness (HP:0003484)4.86294712
21Hyperlipoproteinemia (HP:0010980)4.72926244
22Conjugated hyperbilirubinemia (HP:0002908)4.72428134
23Truncus arteriosus (HP:0001660)4.62585568
24Muscle fiber atrophy (HP:0100295)4.59890948
25Xanthomatosis (HP:0000991)4.41440869
26Spontaneous abortion (HP:0005268)4.41401525
27Abnormal pupillary function (HP:0007686)4.36615535
28Hypolipoproteinemia (HP:0010981)4.29983558
29Keratoconjunctivitis (HP:0001096)4.22639933
30Abnormality of placental membranes (HP:0011409)4.21646497
31Amniotic constriction ring (HP:0009775)4.21646497
32Abnormality of the neuromuscular junction (HP:0003398)4.20053652
33Fatigable weakness (HP:0003473)4.20053652
34Prolonged neonatal jaundice (HP:0006579)3.87168113
35Tongue fasciculations (HP:0001308)3.85738877
36Right ventricular cardiomyopathy (HP:0011663)3.80371659
37Muscle fibrillation (HP:0010546)3.78853209
38Weak cry (HP:0001612)3.74918682
39Eczematoid dermatitis (HP:0000976)3.73329998
40Hyperglycinemia (HP:0002154)3.70042519
41Hydroxyprolinuria (HP:0003080)3.66226904
42Abnormality of proline metabolism (HP:0010907)3.66226904
43Asplenia (HP:0001746)3.53123794
44Abnormality of serum amino acid levels (HP:0003112)3.49978485
45Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.48525844
46Nephritis (HP:0000123)3.47726779
47Recurrent skin infections (HP:0001581)3.47475308
48Abnormal auditory evoked potentials (HP:0006958)3.47317985
49Lip pit (HP:0100267)3.45258587
50Hyperammonemia (HP:0001987)3.44889115
51Abnormal gallbladder physiology (HP:0012438)3.36824833
52Cholecystitis (HP:0001082)3.36824833
53Transposition of the great arteries (HP:0001669)3.33426358
54Abnormal connection of the cardiac segments (HP:0011545)3.33426358
55Abnormal ventriculo-arterial connection (HP:0011563)3.33426358
56Abnormality of the gastric mucosa (HP:0004295)3.24680127
57Abnormality of calcium-phosphate metabolism (HP:0100530)3.23963799
58Hyperglycemia (HP:0003074)3.21785090
59Confusion (HP:0001289)3.14429687
60Hypercortisolism (HP:0001578)3.12294106
61Annular pancreas (HP:0001734)3.11482306
62Generalized aminoaciduria (HP:0002909)3.10894087
63Recurrent fungal infections (HP:0002841)3.07818164
64Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.07250616
65Hyperglycinuria (HP:0003108)3.02709027
66Xerostomia (HP:0000217)3.00187704
67Abnormal pancreas size (HP:0012094)2.99628230
68Abnormality of the aortic arch (HP:0012303)2.96761193
69Abnormality of nucleobase metabolism (HP:0010932)2.89876298
70Hypoplasia of the uterus (HP:0000013)2.89306828
71Bilateral microphthalmos (HP:0007633)2.78904687
72Reticulocytosis (HP:0001923)2.78792732
73Easy fatigability (HP:0003388)2.75376891
74Popliteal pterygium (HP:0009756)2.73391494
75Abnormality of methionine metabolism (HP:0010901)2.69003110
76Increased IgE level (HP:0003212)2.68769742
77Cholelithiasis (HP:0001081)2.67636598
78Symphalangism affecting the phalanges of the hand (HP:0009773)2.66988762
79Gingival bleeding (HP:0000225)2.66357945
80Rickets (HP:0002748)2.60804995
81Hypoalphalipoproteinemia (HP:0003233)2.60418719
82Interstitial pulmonary disease (HP:0006530)2.57272898
83Abnormality of glutamine family amino acid metabolism (HP:0010902)2.56433371
84Hemorrhage of the eye (HP:0011885)2.54619942
85Increased serum pyruvate (HP:0003542)2.52240939
86Ketoacidosis (HP:0001993)2.52133975
87Steatorrhea (HP:0002570)2.49178947
88Osteomalacia (HP:0002749)2.47107034
89Recurrent gram-negative bacterial infections (HP:0005420)2.46914085
90Abnormality of sulfur amino acid metabolism (HP:0004339)2.44820102
91Abnormal gallbladder morphology (HP:0012437)2.44408951
92Hypoplasia of dental enamel (HP:0006297)2.42891954
93Down-sloping shoulders (HP:0200021)2.41090505
94Delayed CNS myelination (HP:0002188)2.40825044
95Recurrent bacterial skin infections (HP:0005406)2.39753591
96Hepatocellular carcinoma (HP:0001402)2.39028064
97Hypercholesterolemia (HP:0003124)2.34425786
98Fetal akinesia sequence (HP:0001989)2.32722156
99Abnormal hand bone ossification (HP:0010660)2.31089547
100Thrombophlebitis (HP:0004418)2.30888957
101Plantar hyperkeratosis (HP:0007556)2.28679065
102Polycythemia (HP:0001901)2.28448064
103Abnormality of glycolysis (HP:0004366)2.28365761
104Menorrhagia (HP:0000132)2.26730999
105Purpura (HP:0000979)2.26422065
106Cerebral edema (HP:0002181)2.26204857
107Pterygium (HP:0001059)2.25144006
108Abnormal ossification of hand bones (HP:0005921)2.24064499
109Neoplasm of the heart (HP:0100544)2.23852208
110Aplasia of the musculature (HP:0100854)2.23639861
111Akinesia (HP:0002304)2.20874791
112Abnormality of the parietal bone (HP:0002696)2.19117220
113Abnormal delayed hypersensitivity skin test (HP:0002963)2.18020833
114Deformed sella turcica (HP:0002681)2.17299879
115Recurrent pneumonia (HP:0006532)2.17202776
116Hyperbilirubinemia (HP:0002904)2.12956303
117Abnormality of aspartate family amino acid metabolism (HP:0010899)2.12686628
118Abnormality of alanine metabolism (HP:0010916)2.12000413
119Hyperalaninemia (HP:0003348)2.12000413
120Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.12000413
121Malignant hyperthermia (HP:0002047)2.11464896
122Poikilocytosis (HP:0004447)2.11182063
123Abnormality of the intrinsic pathway (HP:0010989)2.09848233
124Increased serum ferritin (HP:0003281)2.09552618
125Trismus (HP:0000211)2.09439305
126Bifid scrotum (HP:0000048)2.07562367
127Hyperphosphaturia (HP:0003109)2.07295901
128Palmoplantar hyperkeratosis (HP:0000972)2.07227160
129Paraparesis (HP:0002385)2.07011211
130Abnormality of urine glucose concentration (HP:0011016)2.06897401
131Glycosuria (HP:0003076)2.06897401
132Metabolic acidosis (HP:0001942)2.06764689
133Decreased muscle mass (HP:0003199)2.06385982
134Abnormality of glycine metabolism (HP:0010895)2.05876820
135Abnormality of serine family amino acid metabolism (HP:0010894)2.05876820
136Abnormalities of placenta or umbilical cord (HP:0001194)2.00039282
137Squamous cell carcinoma (HP:0002860)1.99685391
138Aplasia/hypoplasia of the uterus (HP:0008684)1.98655052
139Urticaria (HP:0001025)1.98256874
140Onycholysis (HP:0001806)1.97327685
141Keratitis (HP:0000491)1.96357340
142Respiratory distress (HP:0002098)1.96267227
143Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.95404457
144Pulmonary embolism (HP:0002204)1.95015219
145Bile duct proliferation (HP:0001408)1.93832878
146Abnormal biliary tract physiology (HP:0012439)1.93832878
147Hepatitis (HP:0012115)1.92813463
148Abnormality of the Achilles tendon (HP:0005109)1.92123950
149Alkalosis (HP:0001948)1.91873747
150Pustule (HP:0200039)1.91616946
151Abnormality of iron homeostasis (HP:0011031)1.89719063
152Fair hair (HP:0002286)1.89194673
153Absent phalangeal crease (HP:0006109)1.88856636
154Palmar hyperkeratosis (HP:0010765)1.88813785
155Elevated alkaline phosphatase (HP:0003155)1.88710482
156Irritability (HP:0000737)1.88270954
157Mitral stenosis (HP:0001718)1.88136946
158Amelogenesis imperfecta (HP:0000705)1.86132054
159Myositis (HP:0100614)1.85233357
160Lethargy (HP:0001254)1.84623183
161Recurrent lower respiratory tract infections (HP:0002783)1.84499568
162Abnormality of vitamin metabolism (HP:0100508)1.84453654
163Milia (HP:0001056)1.83411025
164Progressive muscle weakness (HP:0003323)1.83006420
165Poor suck (HP:0002033)1.82756669
166Ketosis (HP:0001946)1.82120830
167Fat malabsorption (HP:0002630)1.81894091
168Abnormality of transition element cation homeostasis (HP:0011030)1.81546560
169Vascular calcification (HP:0004934)1.80768507
170Agammaglobulinemia (HP:0004432)1.80649824
171Anophthalmia (HP:0000528)1.80491181
172Intrahepatic cholestasis (HP:0001406)1.79646925
173Premature loss of primary teeth (HP:0006323)1.79290175
174Atrioventricular block (HP:0001678)1.78671633
175Abnormal delivery (HP:0001787)1.77711405
176Gastrointestinal stroma tumor (HP:0100723)1.77707969
177Short 4th metacarpal (HP:0010044)1.77398437
178Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.77398437
179Abnormality of the gallbladder (HP:0005264)1.77183011
180Hypoproteinemia (HP:0003075)1.76587130
181Reduced antithrombin III activity (HP:0001976)1.76122632
182Arthropathy (HP:0003040)1.74349336
183Abnormality of alkaline phosphatase activity (HP:0004379)1.73363500
184Abnormal enzyme/coenzyme activity (HP:0012379)1.72867168
185Epidermoid cyst (HP:0200040)1.72312251
186Abnormal urine phosphate concentration (HP:0012599)1.72184232
187Lower limb hyperreflexia (HP:0002395)1.71354445
188Gangrene (HP:0100758)1.69622838
189Spastic paraparesis (HP:0002313)1.69011215

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.86993373
2DYRK1B5.25071159
3IRAK44.06296978
4MST1R3.32285358
5IRAK33.29335784
6BMPR23.22316991
7LATS22.81016002
8PDK22.66716138
9STK38L2.65915133
10SRPK12.59688877
11ERBB32.55530716
12PTK62.52042362
13EIF2AK12.44829112
14EPHA32.43877922
15MST42.28453039
16RIPK12.28192738
17NEK12.27510971
18ZAK2.25794283
19NLK2.25789123
20NME12.20589409
21BCKDK2.16677439
22TBK12.16056233
23TTK2.08432353
24ERN11.97663980
25PBK1.95686562
26PIK3CG1.94966180
27FGFR41.94152887
28BCR1.90268679
29PIM21.85863155
30CDC71.80818451
31JAK31.72135280
32VRK21.72099613
33ITK1.70512952
34MUSK1.53427388
35IKBKE1.53047938
36EPHB11.51977196
37TYK21.48979681
38PRKCI1.48802423
39DYRK31.48671111
40MAP3K31.43559367
41ICK1.41560126
42CHUK1.40249526
43NUAK11.39710482
44PRKACG1.35572483
45PRKCG1.34790370
46EPHA21.28765436
47MAP2K21.28036360
48PLK41.26575291
49IKBKB1.25740311
50NEK91.25073748
51ABL21.24037012
52STK161.23700121
53SCYL21.22210225
54NTRK11.16234201
55MELK1.15468246
56AKT31.14331099
57CDC42BPA1.13311003
58JAK21.11170780
59TEC1.10494213
60IRAK11.06204552
61PRKAA21.06083075
62PTK21.04407031
63CAMK1D1.01178738
64CDK61.00864208
65BTK1.00712290
66TLK11.00492814
67NEK20.99907156
68BRSK20.99361097
69TRIB30.97250430
70PKN10.96453221
71MOS0.96136068
72NME20.95323926
73MAP3K130.93207952
74PDPK10.93192864
75CDK40.93071089
76CHEK20.89258123
77PRKCQ0.88913845
78SYK0.88717581
79FGFR30.84313506
80MAPKAPK50.83293385
81CDK70.83136501
82FLT30.82839208
83JAK10.82062833
84CSNK2A10.79306856
85PAK40.78187911
86LMTK20.77788621
87GRK50.76881287
88TNIK0.76636954
89WEE10.72453367
90STK30.72432087
91BUB10.72130410
92TYRO30.70686856
93INSRR0.69661858
94DAPK20.67946074
95PRPF4B0.67169986
96MKNK10.66998531
97CSNK2A20.65749360
98BMPR1B0.64571929
99CSNK1D0.63963481
100PIM10.63734911
101TSSK60.63638468
102WNK40.63587462
103PRKAA10.63433007
104PRKCD0.63048672
105VRK10.61879439
106EIF2AK20.61644688
107AKT20.60768810
108CSNK1E0.60177691
109STK380.57796077
110TAOK20.56431765
111CDK30.55763644
112PRKACA0.54693190
113RPS6KB20.52306032
114SIK30.51286575
115DDR20.51029665
116ERBB40.50148456
117MAP3K80.49839498
118GRK10.49604393
119KIT0.48598480
120AURKB0.48342327
121MAPK110.48141362
122PLK10.47541598
123CDK80.46917899
124TIE10.46909663
125HCK0.45768896
126MAP3K70.42315843
127LATS10.42253588
128PDK10.41555258
129ADRBK20.40652698
130PLK20.39993484
131LRRK20.38689720
132TGFBR10.38582339
133PINK10.38425522
134NEK60.36791005
135DYRK20.36638266
136PDGFRA0.36027048
137BRSK10.35980875
138CAMK40.35968421
139MAP2K10.35589290
140EGFR0.35120014
141RPS6KA50.34067483
142DYRK1A0.33833392
143KDR0.32966738
144SRC0.32817379
145RAF10.32706832
146PRKCE0.32078162
147IGF1R0.31996099
148MATK0.31919758
149MAP3K120.31213731
150PRKCB0.30925027
151FER0.30872135
152PRKDC0.30662434
153PRKCZ0.30247662
154PKN20.30242795
155CAMK1G0.29655831
156STK110.29610873
157CDK10.28268411
158ATR0.27500036
159MAP3K100.27294307
160OXSR10.26938154
161ARAF0.26927367
162CSNK1A10.26715753
163MET0.26304355
164INSR0.24685200
165MAPKAPK20.24241073
166PRKCA0.24061585
167MAPK80.22006216
168ZAP700.21686738
169SIK10.21166611
170PAK20.20325711
171EIF2AK30.20075899
172PRKG20.17914344

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004006.78867678
2Asthma_Homo sapiens_hsa053104.06085660
3Histidine metabolism_Homo sapiens_hsa003403.72149329
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.93975507
5Arginine biosynthesis_Homo sapiens_hsa002202.92687316
6Retinol metabolism_Homo sapiens_hsa008302.90632722
7Drug metabolism - other enzymes_Homo sapiens_hsa009832.65561559
8Primary immunodeficiency_Homo sapiens_hsa053402.59680711
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.58162160
10Caffeine metabolism_Homo sapiens_hsa002322.49794432
11Phenylalanine metabolism_Homo sapiens_hsa003602.41593923
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.25972537
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.19286334
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.17199748
15Primary bile acid biosynthesis_Homo sapiens_hsa001202.09314413
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.00925567
17Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.97839765
18Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.94583418
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.87576404
20Butanoate metabolism_Homo sapiens_hsa006501.82013541
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.79158314
22Antigen processing and presentation_Homo sapiens_hsa046121.77797265
23Linoleic acid metabolism_Homo sapiens_hsa005911.69131827
24Vitamin digestion and absorption_Homo sapiens_hsa049771.58855367
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.58168456
26One carbon pool by folate_Homo sapiens_hsa006701.52361513
27Pancreatic secretion_Homo sapiens_hsa049721.47996742
28Vitamin B6 metabolism_Homo sapiens_hsa007501.47885046
29Tryptophan metabolism_Homo sapiens_hsa003801.43515772
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.36984971
31Autoimmune thyroid disease_Homo sapiens_hsa053201.35937115
32Fat digestion and absorption_Homo sapiens_hsa049751.30874814
33Arginine and proline metabolism_Homo sapiens_hsa003301.29815729
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.25678872
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24832053
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.23256511
37Leishmaniasis_Homo sapiens_hsa051401.21891903
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.21204614
39Ether lipid metabolism_Homo sapiens_hsa005651.20934029
40Carbon metabolism_Homo sapiens_hsa012001.20421726
41Tyrosine metabolism_Homo sapiens_hsa003501.13937061
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.09682248
43NOD-like receptor signaling pathway_Homo sapiens_hsa046211.07701178
44Pentose and glucuronate interconversions_Homo sapiens_hsa000401.06562083
45Protein digestion and absorption_Homo sapiens_hsa049741.03731470
46Pyruvate metabolism_Homo sapiens_hsa006201.03290027
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.98869360
48Allograft rejection_Homo sapiens_hsa053300.98684596
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.96160021
50Propanoate metabolism_Homo sapiens_hsa006400.94453572
51Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.88770103
52Fatty acid metabolism_Homo sapiens_hsa012120.85861232
53Prion diseases_Homo sapiens_hsa050200.83282836
54Biosynthesis of amino acids_Homo sapiens_hsa012300.80920552
55Arachidonic acid metabolism_Homo sapiens_hsa005900.78426976
56ABC transporters_Homo sapiens_hsa020100.75237946
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74932493
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69505822
59Toxoplasmosis_Homo sapiens_hsa051450.68102828
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65914123
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.64391191
62Nitrogen metabolism_Homo sapiens_hsa009100.63370774
63Glycerolipid metabolism_Homo sapiens_hsa005610.62298564
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62064992
65beta-Alanine metabolism_Homo sapiens_hsa004100.61721775
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61277887
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60529673
68Legionellosis_Homo sapiens_hsa051340.60408777
69Osteoclast differentiation_Homo sapiens_hsa043800.58634207
70Chemokine signaling pathway_Homo sapiens_hsa040620.58553004
71Steroid biosynthesis_Homo sapiens_hsa001000.57294821
72Apoptosis_Homo sapiens_hsa042100.56864617
73Chemical carcinogenesis_Homo sapiens_hsa052040.56721272
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56000139
75African trypanosomiasis_Homo sapiens_hsa051430.54656438
76Metabolic pathways_Homo sapiens_hsa011000.53922841
77Peroxisome_Homo sapiens_hsa041460.53428052
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53294876
79Fatty acid degradation_Homo sapiens_hsa000710.52824393
80Lysine degradation_Homo sapiens_hsa003100.52740716
81Dorso-ventral axis formation_Homo sapiens_hsa043200.51786198
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.51129512
83Systemic lupus erythematosus_Homo sapiens_hsa053220.48420978
84Starch and sucrose metabolism_Homo sapiens_hsa005000.48357609
85Amoebiasis_Homo sapiens_hsa051460.48093732
86Fatty acid elongation_Homo sapiens_hsa000620.46759592
87p53 signaling pathway_Homo sapiens_hsa041150.46297004
88Complement and coagulation cascades_Homo sapiens_hsa046100.45046454
89Fructose and mannose metabolism_Homo sapiens_hsa000510.42604309
90Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.41953285
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.41865231
92Pancreatic cancer_Homo sapiens_hsa052120.41014616
93Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39932874
94Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39858532
95Jak-STAT signaling pathway_Homo sapiens_hsa046300.39106396
96Rheumatoid arthritis_Homo sapiens_hsa053230.38785583
97Tuberculosis_Homo sapiens_hsa051520.36138925
98Protein export_Homo sapiens_hsa030600.35122239
99PPAR signaling pathway_Homo sapiens_hsa033200.35112663
100Folate biosynthesis_Homo sapiens_hsa007900.33815674
101Dilated cardiomyopathy_Homo sapiens_hsa054140.30549060
102Selenocompound metabolism_Homo sapiens_hsa004500.30323789
103Small cell lung cancer_Homo sapiens_hsa052220.28707948
104Galactose metabolism_Homo sapiens_hsa000520.28369750
105Calcium signaling pathway_Homo sapiens_hsa040200.28203609
106Fatty acid biosynthesis_Homo sapiens_hsa000610.27298148
107Toll-like receptor signaling pathway_Homo sapiens_hsa046200.25612979
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.25151097
109Glutathione metabolism_Homo sapiens_hsa004800.25129031
110Influenza A_Homo sapiens_hsa051640.24514126
111Staphylococcus aureus infection_Homo sapiens_hsa051500.23805714
112Type I diabetes mellitus_Homo sapiens_hsa049400.23731265
113Sulfur metabolism_Homo sapiens_hsa009200.22884377
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22070632
115Graft-versus-host disease_Homo sapiens_hsa053320.21471543
116Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.20860282
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20760009
118Pentose phosphate pathway_Homo sapiens_hsa000300.20502400
119Salivary secretion_Homo sapiens_hsa049700.20466852
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.19757924
121Pertussis_Homo sapiens_hsa051330.19129635
122Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.17465087
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.17399855
124Bile secretion_Homo sapiens_hsa049760.17139114
125Ribosome_Homo sapiens_hsa030100.15767546
126Measles_Homo sapiens_hsa051620.14959679
127Vibrio cholerae infection_Homo sapiens_hsa051100.12733677
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.12480476
129Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.11481626
130Sulfur relay system_Homo sapiens_hsa041220.09807122
131TNF signaling pathway_Homo sapiens_hsa046680.09484152
132Insulin resistance_Homo sapiens_hsa049310.08205356
133Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.05138738
134DNA replication_Homo sapiens_hsa030300.05047516
135Pyrimidine metabolism_Homo sapiens_hsa002400.04032362
136Adipocytokine signaling pathway_Homo sapiens_hsa049200.03646718
137Renin-angiotensin system_Homo sapiens_hsa046140.02932232
138Mismatch repair_Homo sapiens_hsa034300.02416216
139Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.02067064
140Glucagon signaling pathway_Homo sapiens_hsa049220.02023942
141Mineral absorption_Homo sapiens_hsa04978-0.1097713
142Serotonergic synapse_Homo sapiens_hsa04726-0.0980958
143AMPK signaling pathway_Homo sapiens_hsa04152-0.0821835
144Nucleotide excision repair_Homo sapiens_hsa03420-0.0820140
145Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0793925
146Sphingolipid metabolism_Homo sapiens_hsa00600-0.0745829
147Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0542255
148Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0461742
149N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0241096
150Other glycan degradation_Homo sapiens_hsa00511-0.0024625

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