FGF22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The mouse homolog of this gene was found to be preferentially expressed in the inner root sheath of the hair follicle, which suggested a role in hair development. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of prostaglandin secretion (GO:0032306)9.65288927
2positive regulation of fatty acid biosynthetic process (GO:0045723)9.37193273
3positive regulation of icosanoid secretion (GO:0032305)8.63418403
4positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)8.32047811
5valine metabolic process (GO:0006573)8.08379675
6positive regulation of macrophage activation (GO:0043032)7.41685211
7positive regulation of fatty acid transport (GO:2000193)7.39836021
8positive regulation of macrophage derived foam cell differentiation (GO:0010744)6.83319886
9positive regulation of endothelial cell differentiation (GO:0045603)6.81923506
10behavioral response to nicotine (GO:0035095)6.48801585
11regulation of icosanoid secretion (GO:0032303)6.41244821
12negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)6.11931035
13negative regulation of membrane potential (GO:0045837)6.08742154
14regulation of nitric-oxide synthase biosynthetic process (GO:0051769)6.02382544
15positive regulation of natural killer cell differentiation (GO:0032825)5.93374502
16positive regulation of mitochondrial calcium ion concentration (GO:0051561)5.91975393
17interleukin-1-mediated signaling pathway (GO:0070498)5.55837759
18regulation of macrophage derived foam cell differentiation (GO:0010743)5.07213716
19regulation of endothelial cell differentiation (GO:0045601)4.67549462
20mucosal-associated lymphoid tissue development (GO:0048537)4.66104779
21Peyers patch development (GO:0048541)4.66104779
22regulation of natural killer cell differentiation (GO:0032823)4.45442449
23positive regulation of organic acid transport (GO:0032892)4.44906977
24L-fucose catabolic process (GO:0042355)4.39835695
25fucose catabolic process (GO:0019317)4.39835695
26L-fucose metabolic process (GO:0042354)4.39835695
27release of cytochrome c from mitochondria (GO:0001836)4.38776155
28S-adenosylmethionine metabolic process (GO:0046500)4.27645814
29positive regulation of fatty acid metabolic process (GO:0045923)4.26199829
30tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.20848452
31RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.20848452
32ATP synthesis coupled proton transport (GO:0015986)4.01012509
33energy coupled proton transport, down electrochemical gradient (GO:0015985)4.01012509
34regulation of fatty acid biosynthetic process (GO:0042304)4.00031637
35early endosome to late endosome transport (GO:0045022)3.94368771
36positive regulation of interleukin-17 production (GO:0032740)3.92413190
37regulation of vacuole organization (GO:0044088)3.88506865
38mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.81595406
39creatine metabolic process (GO:0006600)3.79822692
40establishment of protein localization to mitochondrial membrane (GO:0090151)3.72657680
41regulation of synapse structural plasticity (GO:0051823)3.71948154
42negative regulation of telomere maintenance (GO:0032205)3.71896779
43negative regulation of endothelial cell apoptotic process (GO:2000352)3.66429721
44rRNA catabolic process (GO:0016075)3.65481823
45cellular response to interleukin-1 (GO:0071347)3.64628948
46negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.58854143
47regulation of fatty acid transport (GO:2000191)3.50663423
48cellular response to ATP (GO:0071318)3.46747403
49ncRNA 3-end processing (GO:0043628)3.44841591
50detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.43252262
51blastocyst development (GO:0001824)3.38934362
52ribosomal small subunit assembly (GO:0000028)3.37971764
53response to pheromone (GO:0019236)3.37670923
54cellular ketone body metabolic process (GO:0046950)3.37294169
55nephron epithelium morphogenesis (GO:0072088)3.36410021
56nephron tubule morphogenesis (GO:0072078)3.36410021
57water-soluble vitamin biosynthetic process (GO:0042364)3.36373806
58mating behavior (GO:0007617)3.36057270
59mitochondrial calcium ion homeostasis (GO:0051560)3.34437543
60mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.34319709
61mitochondrial respiratory chain complex I assembly (GO:0032981)3.34319709
62NADH dehydrogenase complex assembly (GO:0010257)3.34319709
63kynurenine metabolic process (GO:0070189)3.33336358
64regulation of nuclear cell cycle DNA replication (GO:0033262)3.31953381
65detection of light stimulus involved in sensory perception (GO:0050962)3.30626429
66detection of light stimulus involved in visual perception (GO:0050908)3.30626429
67DNA deamination (GO:0045006)3.28691816
68central nervous system myelination (GO:0022010)3.27770157
69axon ensheathment in central nervous system (GO:0032291)3.27770157
70natural killer cell differentiation (GO:0001779)3.25239378
71endoplasmic reticulum calcium ion homeostasis (GO:0032469)3.24862245
72maturation of 5.8S rRNA (GO:0000460)3.24611392
73mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.22692081
74protein complex biogenesis (GO:0070271)3.21745630
75indolalkylamine metabolic process (GO:0006586)3.20811889
76protein-cofactor linkage (GO:0018065)3.18946430
77regulation of excitatory postsynaptic membrane potential (GO:0060079)3.18281900
78cellular response to vitamin D (GO:0071305)3.16978177
79negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.16432032
80mitochondrial respiratory chain complex assembly (GO:0033108)3.14985135
81reciprocal meiotic recombination (GO:0007131)3.10543760
82reciprocal DNA recombination (GO:0035825)3.10543760
83glucocorticoid receptor signaling pathway (GO:0042921)3.09266688
84tryptophan metabolic process (GO:0006568)3.08121952
85protein localization to synapse (GO:0035418)3.05021855
86nucleoside transmembrane transport (GO:1901642)3.04951731
87neuronal action potential (GO:0019228)3.02832363
88positive regulation of gamma-delta T cell activation (GO:0046645)3.02015324
89regulation of cholesterol homeostasis (GO:2000188)3.00789278
90ketone body metabolic process (GO:1902224)3.00253308
91synaptic transmission, cholinergic (GO:0007271)2.99803752
92nonmotile primary cilium assembly (GO:0035058)2.98929555
93response to cadmium ion (GO:0046686)2.98687380
94negative regulation of Notch signaling pathway (GO:0045746)2.96696501
95cornea development in camera-type eye (GO:0061303)2.96345755
96fatty acid elongation (GO:0030497)2.95468001
97nodal signaling pathway (GO:0038092)2.94054024
98tryptophan catabolic process (GO:0006569)2.93616667
99indole-containing compound catabolic process (GO:0042436)2.93616667
100indolalkylamine catabolic process (GO:0046218)2.93616667
101respiratory chain complex IV assembly (GO:0008535)2.93571929
102calcium-mediated signaling using intracellular calcium source (GO:0035584)2.93166515
103cellular copper ion homeostasis (GO:0006878)2.92531079
104regulation of action potential (GO:0098900)2.91335585
105lymph node development (GO:0048535)2.90546969
106sulfation (GO:0051923)2.88770740
107neutrophil activation involved in immune response (GO:0002283)2.87332831
108vocalization behavior (GO:0071625)2.87016755
109regulation of postsynaptic membrane potential (GO:0060078)2.85188535
110electron transport chain (GO:0022900)2.84909070
111piRNA metabolic process (GO:0034587)2.82263741
112transmission of nerve impulse (GO:0019226)2.78839995
113epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.78187960
114lysine metabolic process (GO:0006553)2.78045219
115lysine catabolic process (GO:0006554)2.78045219
116regulation of macrophage activation (GO:0043030)2.77899392
117response to amine (GO:0014075)2.77476767
118synaptic vesicle exocytosis (GO:0016079)2.75181074
119respiratory electron transport chain (GO:0022904)2.74272096
120positive regulation of triglyceride biosynthetic process (GO:0010867)2.74247093
121ubiquinone biosynthetic process (GO:0006744)2.73154874
122protein localization to cilium (GO:0061512)2.69568621
123positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.68281207
124positive regulation of natural killer cell activation (GO:0032816)2.68230212
125ubiquinone metabolic process (GO:0006743)2.67427645
126cytochrome complex assembly (GO:0017004)2.67358896
127primary amino compound metabolic process (GO:1901160)2.67122934
128intracellular protein transmembrane import (GO:0044743)2.66259067
129positive regulation of triglyceride lipase activity (GO:0061365)2.66211903
130positive regulation of lipoprotein lipase activity (GO:0051006)2.66211903
131gamma-aminobutyric acid transport (GO:0015812)2.66023574
132indole-containing compound metabolic process (GO:0042430)2.64426719
133axoneme assembly (GO:0035082)2.63645810
134postsynaptic membrane organization (GO:0001941)2.62671468
135sleep (GO:0030431)2.62441983
136hydrogen ion transmembrane transport (GO:1902600)2.62177308
137synaptic vesicle maturation (GO:0016188)2.61943524
138negative regulation of reactive oxygen species metabolic process (GO:2000378)2.61636673
139spinal cord motor neuron differentiation (GO:0021522)2.61270425
140detection of mechanical stimulus involved in sensory perception (GO:0050974)2.60795363
141glycerophospholipid catabolic process (GO:0046475)2.60299970
142neuron fate determination (GO:0048664)2.60279544
143synaptic transmission, glutamatergic (GO:0035249)2.59922407
144regulation of gamma-delta T cell differentiation (GO:0045586)2.58539488
145platelet dense granule organization (GO:0060155)2.58067453
146somite development (GO:0061053)2.57690791
147fucosylation (GO:0036065)2.57265586
148regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.56017305
149epithelial cilium movement (GO:0003351)2.55471515
150atrial cardiac muscle cell action potential (GO:0086014)2.55097677
151protein palmitoylation (GO:0018345)2.54535238
152negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.54113372
153mature B cell differentiation involved in immune response (GO:0002313)2.52773915
154positive regulation of transforming growth factor beta production (GO:0071636)2.52616980
155phosphatidylinositol acyl-chain remodeling (GO:0036149)2.52579040
156proline transport (GO:0015824)2.52334405
157proton transport (GO:0015992)2.52249710
158oligodendrocyte differentiation (GO:0048709)2.52037859
159male meiosis I (GO:0007141)2.51595301
160urinary tract smooth muscle contraction (GO:0014848)2.51370759
161neuronal action potential propagation (GO:0019227)2.49812836
162G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.49811220
163regulation of rhodopsin mediated signaling pathway (GO:0022400)2.49589068
164glutamate secretion (GO:0014047)2.49349640
165mitotic cell cycle arrest (GO:0071850)2.49248364
166positive regulation of nitric oxide biosynthetic process (GO:0045429)2.49212153
167positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.48892133
168peristalsis (GO:0030432)2.48852492
169aspartate family amino acid catabolic process (GO:0009068)2.48721323
170negative regulation of mast cell activation (GO:0033004)2.47670209
171hydrogen transport (GO:0006818)2.47279006
172positive regulation of dendritic spine development (GO:0060999)2.47048139
173ATP biosynthetic process (GO:0006754)2.46692356
174neuromuscular synaptic transmission (GO:0007274)2.45924111
175nucleotide transmembrane transport (GO:1901679)2.45598483
176protein neddylation (GO:0045116)2.45102080
177DNA replication checkpoint (GO:0000076)2.44686393
178filopodium assembly (GO:0046847)2.44679896
179branched-chain amino acid metabolic process (GO:0009081)2.44328388
180ionotropic glutamate receptor signaling pathway (GO:0035235)2.44133485
181negative regulation of synaptic transmission, GABAergic (GO:0032229)2.43991285
182photoreceptor cell development (GO:0042461)2.43513226
183positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)2.43395884
184regulation of endothelial cell apoptotic process (GO:2000351)2.42978879
185layer formation in cerebral cortex (GO:0021819)2.42316496
186behavioral response to cocaine (GO:0048148)2.42309615
187protein K6-linked ubiquitination (GO:0085020)2.42295537
188neuron cell-cell adhesion (GO:0007158)2.41984788
189mitochondrial fission (GO:0000266)2.41307716
190regulation of telomere maintenance (GO:0032204)2.41187905
191regulation of Cdc42 GTPase activity (GO:0043088)2.40508511
192protein import into peroxisome matrix (GO:0016558)2.40223254
193preassembly of GPI anchor in ER membrane (GO:0016254)2.39636830
194sodium-independent organic anion transport (GO:0043252)14.9110016
195positive regulation of prostaglandin secretion (GO:0032308)11.1217991

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse6.49769707
2ZNF274_21170338_ChIP-Seq_K562_Hela5.38576791
3AR_21572438_ChIP-Seq_LNCaP_Human4.42979105
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.46707936
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.27711846
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.26379904
7NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.85259397
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.78076631
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.71789651
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.68895239
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.54755887
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.53855776
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.51459843
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.47469413
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.36717752
16GBX2_23144817_ChIP-Seq_PC3_Human2.36575981
17EZH2_22144423_ChIP-Seq_EOC_Human2.34274288
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.33193999
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.32403692
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.21213331
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.21213331
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.17995638
23MTF2_20144788_ChIP-Seq_MESCs_Mouse2.11946751
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.10539910
25EWS_26573619_Chip-Seq_HEK293_Human2.06892709
26GATA1_26923725_Chip-Seq_HPCs_Mouse2.06581871
27CTBP1_25329375_ChIP-Seq_LNCAP_Human2.05124303
28SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.04791984
29SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.01829250
30FUS_26573619_Chip-Seq_HEK293_Human1.99927491
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.97417039
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.95917320
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95750408
34RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91319506
35TAF15_26573619_Chip-Seq_HEK293_Human1.90494020
36RING1B_27294783_Chip-Seq_NPCs_Mouse1.90133213
37SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.89403145
38GABP_17652178_ChIP-ChIP_JURKAT_Human1.84829921
39* KDM2B_26808549_Chip-Seq_K562_Human1.80349093
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.78380307
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.74957704
42IGF1R_20145208_ChIP-Seq_DFB_Human1.74398165
43TP53_22573176_ChIP-Seq_HFKS_Human1.70836148
44SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.70314891
45ER_23166858_ChIP-Seq_MCF-7_Human1.69830543
46TP63_19390658_ChIP-ChIP_HaCaT_Human1.68734310
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.67404793
48MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.66569906
49SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.66030263
50EST1_17652178_ChIP-ChIP_JURKAT_Human1.65783409
51MYC_18940864_ChIP-ChIP_HL60_Human1.59035697
52TP53_16413492_ChIP-PET_HCT116_Human1.58131952
53KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.57551663
54CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.55983328
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.54736191
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.51073176
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.49958473
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49090420
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46969630
60P300_19829295_ChIP-Seq_ESCs_Human1.46812380
61ETV2_25802403_ChIP-Seq_MESCs_Mouse1.46501603
62* GATA3_21878914_ChIP-Seq_MCF-7_Human1.46193193
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45641229
64SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.45410439
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43933059
66TDRD3_21172665_ChIP-Seq_MCF-7_Human1.43227034
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41441107
68TP53_20018659_ChIP-ChIP_R1E_Mouse1.40826595
69IRF1_19129219_ChIP-ChIP_H3396_Human1.39507084
70LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.38956402
71WT1_19549856_ChIP-ChIP_CCG9911_Human1.38849532
72SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.38275098
73TAF2_19829295_ChIP-Seq_ESCs_Human1.37315227
74FOXA1_25329375_ChIP-Seq_VCAP_Human1.36795626
75FOXA1_27270436_Chip-Seq_PROSTATE_Human1.36795626
76* ERA_21632823_ChIP-Seq_H3396_Human1.36303241
77NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.36144860
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.34612704
79EED_16625203_ChIP-ChIP_MESCs_Mouse1.33494853
80PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33195307
81CTCF_20526341_ChIP-Seq_ESCs_Human1.32088130
82NCOR_22424771_ChIP-Seq_293T_Human1.30611734
83STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28841262
84SOX9_24532713_ChIP-Seq_HFSC_Mouse1.27761046
85EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.26537251
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24710863
87RING1B_27294783_Chip-Seq_ESCs_Mouse1.24066321
88REST_18959480_ChIP-ChIP_MESCs_Mouse1.23106560
89ETS1_20019798_ChIP-Seq_JURKAT_Human1.21058953
90TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20890952
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20890952
92SOX3_22085726_ChIP-Seq_NPCs_Mouse1.20175133
93WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19959068
94BCAT_22108803_ChIP-Seq_LS180_Human1.19526510
95P53_21459846_ChIP-Seq_SAOS-2_Human1.18458308
96HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18183827
97VDR_23849224_ChIP-Seq_CD4+_Human1.17723087
98MYC_19829295_ChIP-Seq_ESCs_Human1.17129092
99HOXB7_26014856_ChIP-Seq_BT474_Human1.16561802
100RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.16499540
101IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15868683
102CBP_20019798_ChIP-Seq_JUKART_Human1.15868683
103JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.15656421
104KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14316678
105NANOG_20526341_ChIP-Seq_ESCs_Human1.13696019
106SOX2_19829295_ChIP-Seq_ESCs_Human1.11769753
107NANOG_19829295_ChIP-Seq_ESCs_Human1.11769753
108KDM2B_26808549_Chip-Seq_DND41_Human1.11660213
109RNF2_27304074_Chip-Seq_NSC_Mouse1.10132919
110CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.10072064
111WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09981941
112SA1_27219007_Chip-Seq_Bcells_Human1.09623362
113TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07865566
114LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07250419
115PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06972758
116RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06967735
117AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06268029
118REST_21632747_ChIP-Seq_MESCs_Mouse1.06199673
119POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05586291
120AR_20517297_ChIP-Seq_VCAP_Human1.04233071
121NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.03760418
122SMAD4_21741376_ChIP-Seq_EPCs_Human1.02729087
123EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02167173
124TP53_18474530_ChIP-ChIP_U2OS_Human1.01058130
125EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.00962090
126STAT3_23295773_ChIP-Seq_U87_Human1.00556752
127GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.00530992
128PIAS1_25552417_ChIP-Seq_VCAP_Human1.00351757
129FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00182463
130OCT4_20526341_ChIP-Seq_ESCs_Human0.99270196
131RUNX2_22187159_ChIP-Seq_PCA_Human0.98769595
132SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.98662797
133SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97895504
134NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97346675
135OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97160435
136AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97012008
137TCF4_22108803_ChIP-Seq_LS180_Human0.96601403
138MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96229279
139CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96171758
140AR_25329375_ChIP-Seq_VCAP_Human0.95406992
141SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95215756
142E2F1_20622854_ChIP-Seq_HELA_Human0.95139514
143KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.94860647
144CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94760502
145KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93375672
146BMI1_23680149_ChIP-Seq_NPCS_Mouse0.92987517
147ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.92800657
148ZFP281_18757296_ChIP-ChIP_E14_Mouse0.92707722
149KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.91515510
150KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.91515510
151KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.91515510
152BCL6_27268052_Chip-Seq_Bcells_Human0.91026645
153POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89359771
154IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.89259640
155RAD21_21589869_ChIP-Seq_MESCs_Mouse0.87957606
156MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87860607
157RARB_27405468_Chip-Seq_BRAIN_Mouse0.87852188
158PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.87038014
159ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86026216
160SCL_19346495_ChIP-Seq_HPC-7_Human0.85978763
161VDR_22108803_ChIP-Seq_LS180_Human0.85341276
162* TCF7_22412390_ChIP-Seq_EML_Mouse0.83999003
163ZNF217_24962896_ChIP-Seq_MCF-7_Human0.83105603
164CTCF_27219007_Chip-Seq_Bcells_Human0.82870855
165NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.82226466
166RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.80929303
167RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.80494875
168FOXH1_21741376_ChIP-Seq_ESCs_Human0.79781839
169CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.77950075
170LXR_22292898_ChIP-Seq_THP-1_Human0.77898202
171LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.77804479
172SOX2_21211035_ChIP-Seq_LN229_Gbm0.77604994
173MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.76801422
174TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.75933058
175PRDM14_20953172_ChIP-Seq_ESCs_Human0.75072681

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009278_abnormal_bone_marrow5.13940693
2MP0003136_yellow_coat_color3.99555481
3MP0003329_amyloid_beta_deposits3.90082056
4MP0003880_abnormal_central_pattern3.81166547
5MP0003191_abnormal_cellular_cholesterol3.57857720
6MP0004859_abnormal_synaptic_plasticity3.50551984
7MP0002653_abnormal_ependyma_morphology3.44519554
8MP0008872_abnormal_physiological_respon3.32403496
9MP0004270_analgesia3.21085349
10MP0005166_decreased_susceptibility_to3.02691683
11MP0004742_abnormal_vestibular_system2.79057467
12MP0002736_abnormal_nociception_after2.78669644
13MP0009840_abnormal_foam_cell2.74486150
14MP0001986_abnormal_taste_sensitivity2.70918735
15* MP0003635_abnormal_synaptic_transmissio2.67780169
16MP0010368_abnormal_lymphatic_system2.62987638
17MP0005551_abnormal_eye_electrophysiolog2.56235451
18MP0002272_abnormal_nervous_system2.54626533
19MP0009046_muscle_twitch2.47188756
20MP0001968_abnormal_touch/_nociception2.46395458
21MP0001486_abnormal_startle_reflex2.43872982
22MP0002102_abnormal_ear_morphology2.42772197
23* MP0002064_seizures2.27404737
24MP0005409_darkened_coat_color2.26185302
25MP0000604_amyloidosis2.23658010
26MP0008875_abnormal_xenobiotic_pharmacok2.18291952
27MP0003195_calcinosis2.15503548
28MP0003221_abnormal_cardiomyocyte_apopto2.15240417
29MP0002638_abnormal_pupillary_reflex2.02817142
30MP0003011_delayed_dark_adaptation1.99063275
31MP0000534_abnormal_ureter_morphology1.91723107
32MP0003868_abnormal_feces_composition1.86348228
33MP0001545_abnormal_hematopoietic_system1.85886481
34MP0005397_hematopoietic_system_phenotyp1.85886481
35* MP0009745_abnormal_behavioral_response1.85848714
36MP0004147_increased_porphyrin_level1.84751376
37MP0000920_abnormal_myelination1.81068045
38MP0005174_abnormal_tail_pigmentation1.80099845
39MP0004133_heterotaxia1.77243829
40MP0009764_decreased_sensitivity_to1.75313287
41MP0005408_hypopigmentation1.70093845
42MP0001485_abnormal_pinna_reflex1.66070003
43MP0002837_dystrophic_cardiac_calcinosis1.65624827
44MP0001873_stomach_inflammation1.63924669
45MP0002234_abnormal_pharynx_morphology1.63397032
46MP0000751_myopathy1.59998556
47MP0002735_abnormal_chemical_nociception1.58750430
48MP0009379_abnormal_foot_pigmentation1.57919809
49MP0002160_abnormal_reproductive_system1.57818524
50MP0006292_abnormal_olfactory_placode1.56175062
51MP0001188_hyperpigmentation1.55264582
52MP0004883_abnormal_blood_vessel1.54903469
53MP0005253_abnormal_eye_physiology1.54282985
54MP0005645_abnormal_hypothalamus_physiol1.54181853
55MP0003646_muscle_fatigue1.53817145
56MP0000685_abnormal_immune_system1.53638946
57MP0006072_abnormal_retinal_apoptosis1.50738381
58MP0005084_abnormal_gallbladder_morpholo1.50499190
59MP0006276_abnormal_autonomic_nervous1.50281306
60MP0001529_abnormal_vocalization1.46491059
61MP0002796_impaired_skin_barrier1.46450977
62MP0003950_abnormal_plasma_membrane1.45524623
63MP0002277_abnormal_respiratory_mucosa1.45315136
64MP0004043_abnormal_pH_regulation1.43707806
65MP0000631_abnormal_neuroendocrine_gland1.41527572
66MP0002067_abnormal_sensory_capabilities1.39226849
67MP0001664_abnormal_digestion1.38464973
68MP0008874_decreased_physiological_sensi1.36515065
69MP0004142_abnormal_muscle_tone1.35139779
70MP0003866_abnormal_defecation1.33543414
71MP0001919_abnormal_reproductive_system1.30610110
72MP0005389_reproductive_system_phenotype1.30160442
73MP0002938_white_spotting1.27311206
74MP0002734_abnormal_mechanical_nocicepti1.26616780
75MP0002876_abnormal_thyroid_physiology1.24587868
76MP0002063_abnormal_learning/memory/cond1.23934989
77MP0001502_abnormal_circadian_rhythm1.22022272
78MP0004085_abnormal_heartbeat1.21662727
79MP0002572_abnormal_emotion/affect_behav1.20584398
80MP0000427_abnormal_hair_cycle1.15618087
81MP0000747_muscle_weakness1.14694105
82MP0003690_abnormal_glial_cell1.12984687
83MP0002928_abnormal_bile_duct1.11542411
84MP0000026_abnormal_inner_ear1.11415283
85MP0010678_abnormal_skin_adnexa1.10863999
86MP0000465_gastrointestinal_hemorrhage1.10791330
87MP0000372_irregular_coat_pigmentation1.09211541
88MP0003137_abnormal_impulse_conducting1.07027747
89MP0000955_abnormal_spinal_cord1.06903035
90MP0005195_abnormal_posterior_eye1.03775761
91MP0002557_abnormal_social/conspecific_i1.03473451
92MP0002751_abnormal_autonomic_nervous1.01898028
93MP0002184_abnormal_innervation1.01049107
94MP0001905_abnormal_dopamine_level0.98135060
95MP0010386_abnormal_urinary_bladder0.96314434
96MP0002752_abnormal_somatic_nervous0.96046776
97MP0001984_abnormal_olfaction0.95454172
98MP0005386_behavior/neurological_phenoty0.95042835
99MP0004924_abnormal_behavior0.95042835
100MP0005423_abnormal_somatic_nervous0.93589566
101MP0002733_abnormal_thermal_nociception0.93294159
102MP0004510_myositis0.92871513
103MP0002909_abnormal_adrenal_gland0.91836561
104MP0003283_abnormal_digestive_organ0.91824920
105MP0003632_abnormal_nervous_system0.91202758
106MP0001324_abnormal_eye_pigmentation0.90327104
107MP0000383_abnormal_hair_follicle0.89728761
108MP0002210_abnormal_sex_determination0.88509862
109MP0005410_abnormal_fertilization0.87555515
110MP0000647_abnormal_sebaceous_gland0.87374636
111MP0001970_abnormal_pain_threshold0.87331942
112MP0010234_abnormal_vibrissa_follicle0.87329180
113MP0003693_abnormal_embryo_hatching0.87224718
114MP0002095_abnormal_skin_pigmentation0.87148529
115MP0001963_abnormal_hearing_physiology0.86234944
116MP0005167_abnormal_blood-brain_barrier0.85879488
117MP0003119_abnormal_digestive_system0.85159852
118MP0004036_abnormal_muscle_relaxation0.84753736
119* MP0002882_abnormal_neuron_morphology0.84284281
120MP0004233_abnormal_muscle_weight0.83873186
121MP0002139_abnormal_hepatobiliary_system0.83389470
122MP0004215_abnormal_myocardial_fiber0.82533208
123MP0003698_abnormal_male_reproductive0.82484984
124MP0005085_abnormal_gallbladder_physiolo0.78473157
125MP0002229_neurodegeneration0.77275733
126MP0003787_abnormal_imprinting0.77149017
127MP0008058_abnormal_DNA_repair0.75864682
128MP0001727_abnormal_embryo_implantation0.75571031
129MP0003300_gastrointestinal_ulcer0.75382033
130MP0003718_maternal_effect0.74942747
131MP0001293_anophthalmia0.74923671
132MP0005646_abnormal_pituitary_gland0.74572940
133MP0001929_abnormal_gametogenesis0.74384012
134MP0001440_abnormal_grooming_behavior0.73970554
135MP0002066_abnormal_motor_capabilities/c0.73779938
136MP0008877_abnormal_DNA_methylation0.73708255
137MP0003878_abnormal_ear_physiology0.73602818
138MP0005377_hearing/vestibular/ear_phenot0.73602818
139MP0000749_muscle_degeneration0.72785574
140MP0003631_nervous_system_phenotype0.71286777
141MP0004885_abnormal_endolymph0.70793423
142MP0004145_abnormal_muscle_electrophysio0.68592794
143MP0003303_peritoneal_inflammation0.68583477
144MP0003075_altered_response_to0.68296535
145MP0003634_abnormal_glial_cell0.67256594
146MP0005670_abnormal_white_adipose0.66780468
147MP0005451_abnormal_body_composition0.66259536
148MP0003938_abnormal_ear_development0.63926513
149MP0000778_abnormal_nervous_system0.62858029
150MP0005164_abnormal_response_to0.62556623
151MP0001851_eye_inflammation0.62433364
152MP0010155_abnormal_intestine_physiology0.62304510
153MP0005381_digestive/alimentary_phenotyp0.60941867
154* MP0004811_abnormal_neuron_physiology0.60514649
155MP0005023_abnormal_wound_healing0.59862373
156MP0005332_abnormal_amino_acid0.59300637
157MP0005365_abnormal_bile_salt0.58182243
158MP0001663_abnormal_digestive_system0.57164868
159MP0003633_abnormal_nervous_system0.55665884
160MP0001501_abnormal_sleep_pattern0.54417826
161MP0005171_absent_coat_pigmentation0.52732269
162MP0005584_abnormal_enzyme/coenzyme_acti0.51891611

Predicted human phenotypes

RankGene SetZ-score
1Centrally nucleated skeletal muscle fibers (HP:0003687)7.70829741
2Nonprogressive disorder (HP:0003680)7.53555002
3Increased variability in muscle fiber diameter (HP:0003557)6.12523135
4Poor head control (HP:0002421)5.38585527
5Weak cry (HP:0001612)5.22603510
6Abnormality of skeletal muscle fiber size (HP:0012084)5.22398004
7Hypoventilation (HP:0002791)5.13113426
8Poor suck (HP:0002033)4.88241154
9High pitched voice (HP:0001620)4.55002970
10Congenital stationary night blindness (HP:0007642)4.53236992
11Microvesicular hepatic steatosis (HP:0001414)4.33229121
12Abnormality of fatty-acid metabolism (HP:0004359)4.32421125
13Spinal rigidity (HP:0003306)4.27973273
14Hypoplasia of the pons (HP:0012110)4.20989149
15Aortic aneurysm (HP:0004942)4.16195433
16Molar tooth sign on MRI (HP:0002419)4.03940500
17Abnormality of midbrain morphology (HP:0002418)4.03940500
18Abnormality of the pons (HP:0007361)3.98591737
19Turricephaly (HP:0000262)3.96513970
20Pancreatic cysts (HP:0001737)3.92894244
21Death in childhood (HP:0003819)3.87047781
22Abnormality of the periventricular white matter (HP:0002518)3.85960792
23True hermaphroditism (HP:0010459)3.67557433
24Bulbar palsy (HP:0001283)3.64424754
25Birth length less than 3rd percentile (HP:0003561)3.61625775
26Nephronophthisis (HP:0000090)3.55462790
27Pancreatic fibrosis (HP:0100732)3.52949588
28Opisthotonus (HP:0002179)3.46159482
29Generalized amyotrophy (HP:0003700)3.43584386
30Fair hair (HP:0002286)3.41158822
31Generalized hypopigmentation of hair (HP:0011358)3.38710869
32Nasal speech (HP:0001611)3.36588946
33Type II lissencephaly (HP:0007260)3.31941307
34Widely patent fontanelles and sutures (HP:0004492)3.27459819
35Restlessness (HP:0000711)3.25766526
36Focal motor seizures (HP:0011153)3.22706886
37Protrusio acetabuli (HP:0003179)3.20700696
38Attenuation of retinal blood vessels (HP:0007843)3.18799594
39Renal cortical cysts (HP:0000803)3.17593094
40Thrombocytosis (HP:0001894)3.13668722
41Volvulus (HP:0002580)3.11700165
42Impaired smooth pursuit (HP:0007772)3.11685034
43Adrenal hypoplasia (HP:0000835)3.02807519
44Pendular nystagmus (HP:0012043)2.93836942
45Abnormality of the renal medulla (HP:0100957)2.92941380
46Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.90779048
47Abnormality of alanine metabolism (HP:0010916)2.90779048
48Hyperalaninemia (HP:0003348)2.90779048
49Patellar aplasia (HP:0006443)2.85538669
50Congenital, generalized hypertrichosis (HP:0004540)2.83205622
51Inability to walk (HP:0002540)2.82211559
52Arterial tortuosity (HP:0005116)2.79697716
53Dyskinesia (HP:0100660)2.76040108
54Rib fusion (HP:0000902)2.75823487
55Myokymia (HP:0002411)2.74118515
56Aplasia/Hypoplasia of the patella (HP:0006498)2.71693497
57Tubular atrophy (HP:0000092)2.69448154
58Congenital hip dislocation (HP:0001374)2.68428281
59Muscular dystrophy (HP:0003560)2.64856586
60Medial flaring of the eyebrow (HP:0010747)2.63959774
61Acute necrotizing encephalopathy (HP:0006965)2.63556277
62Abnormal number of erythroid precursors (HP:0012131)2.61093648
63Concave nail (HP:0001598)2.59091429
64Mitochondrial inheritance (HP:0001427)2.58406910
65Papilledema (HP:0001085)2.58218697
66Breech presentation (HP:0001623)2.55690078
67Aortic dissection (HP:0002647)2.54328165
68Asplenia (HP:0001746)2.54235573
69Sclerocornea (HP:0000647)2.53961384
70Chorioretinal atrophy (HP:0000533)2.50680849
71Generalized muscle weakness (HP:0003324)2.48943751
72Abnormal drinking behavior (HP:0030082)2.48290647
73Polydipsia (HP:0001959)2.48290647
74Lumbar hyperlordosis (HP:0002938)2.47422279
75Vascular tortuosity (HP:0004948)2.46887253
76Male pseudohermaphroditism (HP:0000037)2.43927365
77Chronic hepatic failure (HP:0100626)2.43402765
78Lipid accumulation in hepatocytes (HP:0006561)2.43170459
79Progressive microcephaly (HP:0000253)2.42855269
80Absent thumb (HP:0009777)2.41967037
81Cerebellar dysplasia (HP:0007033)2.41768376
82Cystic liver disease (HP:0006706)2.40401072
83Hyperlipoproteinemia (HP:0010980)2.40136370
84Dynein arm defect of respiratory motile cilia (HP:0012255)2.39238844
85Absent/shortened dynein arms (HP:0200106)2.39238844
86Progressive inability to walk (HP:0002505)2.36653355
87Mesangial abnormality (HP:0001966)2.35887851
88Decreased central vision (HP:0007663)2.34854208
89Increased CSF lactate (HP:0002490)2.34029876
90Optic disc pallor (HP:0000543)2.32877882
91Increased hepatocellular lipid droplets (HP:0006565)2.31515117
92Aplasia/Hypoplasia of the spleen (HP:0010451)2.31429933
93Bony spicule pigmentary retinopathy (HP:0007737)2.30735215
94Acute encephalopathy (HP:0006846)2.29173449
95Testicular atrophy (HP:0000029)2.28862080
96Retinal dysplasia (HP:0007973)2.27285537
97Abnormality of ocular smooth pursuit (HP:0000617)2.26759531
98Wide cranial sutures (HP:0010537)2.26496785
99Febrile seizures (HP:0002373)2.25456751
100Severe global developmental delay (HP:0011344)2.25379985
101Epileptic encephalopathy (HP:0200134)2.24979446
102Gait imbalance (HP:0002141)2.24033465
103Flat occiput (HP:0005469)2.22577034
104Anxiety (HP:0000739)2.22402052
105Respiratory insufficiency due to muscle weakness (HP:0002747)2.22374002
106Abnormality of cells of the erythroid lineage (HP:0012130)2.19826281
107Bell-shaped thorax (HP:0001591)2.19723150
108Decreased electroretinogram (ERG) amplitude (HP:0000654)2.19349372
109Progressive macrocephaly (HP:0004481)2.17796534
110Abnormal mitochondria in muscle tissue (HP:0008316)2.17347581
111Large for gestational age (HP:0001520)2.17067854
112Dilated cardiomyopathy (HP:0001644)2.16828425
113Lissencephaly (HP:0001339)2.16825826
114Abnormality of aromatic amino acid family metabolism (HP:0004338)2.16682359
115Abolished electroretinogram (ERG) (HP:0000550)2.14718926
116Aplasia/Hypoplasia of the brainstem (HP:0007362)2.14340030
117Hypoplasia of the brainstem (HP:0002365)2.14340030
118Heterotopia (HP:0002282)2.13213625
1193-Methylglutaconic aciduria (HP:0003535)2.11181519
120Spondylolisthesis (HP:0003302)2.09369516
121Breast hypoplasia (HP:0003187)2.07241838
122Abnormality of the renal cortex (HP:0011035)2.07058123
123Aplasia/Hypoplasia of the uvula (HP:0010293)2.05865243
124Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.05498887
125Focal seizures (HP:0007359)2.03335702
126Anencephaly (HP:0002323)2.02893221
127Polyuria (HP:0000103)2.01078999
128Redundant skin (HP:0001582)2.00855096
129Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.99474381
130Congenital primary aphakia (HP:0007707)1.99234156
131Renal Fanconi syndrome (HP:0001994)1.98526554
132Hepatocellular necrosis (HP:0001404)1.97809627
133Abnormal rod and cone electroretinograms (HP:0008323)1.96397036
134Protruding tongue (HP:0010808)1.95780299
135Hyperventilation (HP:0002883)1.95079094
136Abnormality of urine glucose concentration (HP:0011016)1.94340648
137Glycosuria (HP:0003076)1.94340648
138Furrowed tongue (HP:0000221)1.92285118
139Bile duct proliferation (HP:0001408)1.90991228
140Abnormal biliary tract physiology (HP:0012439)1.90991228
141Type 2 muscle fiber atrophy (HP:0003554)1.88687696
142Congenital hepatic fibrosis (HP:0002612)1.88081124
143Oligomenorrhea (HP:0000876)1.85825970
144Anteriorly placed anus (HP:0001545)1.84193791
145Action tremor (HP:0002345)1.83445156
146Vacuolated lymphocytes (HP:0001922)1.83098179
147Decreased circulating renin level (HP:0003351)1.81769528
148Keratoconus (HP:0000563)1.81753007
149Increased corneal curvature (HP:0100692)1.81753007
150Abnormal respiratory motile cilium morphology (HP:0005938)1.81543568
151Abnormal respiratory epithelium morphology (HP:0012253)1.81543568
152Interstitial pulmonary disease (HP:0006530)1.81520337
153Bilateral microphthalmos (HP:0007633)1.80867189
154Severe muscular hypotonia (HP:0006829)1.80156941
155Nephrogenic diabetes insipidus (HP:0009806)1.79551537
156Aplasia/Hypoplasia of the tongue (HP:0010295)1.76662284
157Aneurysm (HP:0002617)1.75171052
158Meckel diverticulum (HP:0002245)1.74321711
159Anophthalmia (HP:0000528)1.74314168
160Neonatal hypotonia (HP:0001319)1.74265390
161Progressive cerebellar ataxia (HP:0002073)1.73832034
162Hepatic necrosis (HP:0002605)1.73804565
163Supraventricular tachycardia (HP:0004755)1.73611493
164Confusion (HP:0001289)1.73161602
165Hypoalbuminemia (HP:0003073)1.73136328
166Abnormal albumin level (HP:0012116)1.73136328
167Sensory axonal neuropathy (HP:0003390)1.72700812
168Pelvic girdle muscle weakness (HP:0003749)1.72071390
169Genetic anticipation (HP:0003743)1.71727796
170Restrictive lung disease (HP:0002091)1.69968271
171Tachypnea (HP:0002789)1.69750858
172Neonatal respiratory distress (HP:0002643)1.69009564
173Abnormal hair whorl (HP:0010721)1.68805801
174Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.68683842
175Supraventricular arrhythmia (HP:0005115)1.68655786
176Increased serum lactate (HP:0002151)1.68557280
177Abnormality of the ileum (HP:0001549)1.68385713
178Optic nerve hypoplasia (HP:0000609)1.68013119
179Vaginal atresia (HP:0000148)1.67045943
180Abnormality of the renal collecting system (HP:0004742)1.65954124
181Aplasia/Hypoplasia of the sacrum (HP:0008517)1.65314931
182Hypoplasia of the radius (HP:0002984)1.64608280
183Blue irides (HP:0000635)1.63330611
184Abnormality of the hip-girdle musculature (HP:0001445)1.62225570
185Abnormality of the musculature of the pelvis (HP:0001469)1.62225570
186Atrial fibrillation (HP:0005110)1.61711446
187Blepharitis (HP:0000498)1.60565135
188Ventricular tachycardia (HP:0004756)1.57919765
189Oligodactyly (hands) (HP:0001180)1.55084984
190Primary atrial arrhythmia (HP:0001692)1.52842596
191Hypoglycemic coma (HP:0001325)1.46850703
192Prolonged neonatal jaundice (HP:0006579)1.45359928
193Foot dorsiflexor weakness (HP:0009027)1.43210589
194Neurofibrillary tangles (HP:0002185)1.42950262
195Lack of skin elasticity (HP:0100679)1.41837116
196Striae distensae (HP:0001065)1.40128015
197Absence seizures (HP:0002121)1.38521521

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K49.11234513
2MAP2K79.03434188
3MAP2K45.17382615
4CDK34.28401499
5BMPR1B4.14496185
6ADRBK23.40711025
7WNK43.34421511
8CAMK1D2.85217414
9MAPK152.83973379
10MAP4K22.80837650
11WNK32.77903847
12CAMKK22.72385552
13FRK2.68447523
14CAMK1G2.64548766
15TLK12.64331045
16GRK12.33602286
17RET2.28904395
18INSRR2.28366175
19ZAK2.26246581
20ACVR1B2.23941036
21MAPK132.07351547
22TGFBR11.78619953
23PINK11.73185133
24TAOK31.73043905
25MAP2K61.58287501
26CDK81.57613500
27MYLK1.47308400
28BCKDK1.42478633
29WEE11.42472141
30NUAK11.41117961
31ADRBK11.34569645
32STK38L1.33940111
33MUSK1.29823257
34EPHA41.27868171
35CAMKK11.24195219
36TXK1.18424247
37TSSK61.18326893
38IRAK11.11738233
39MAPKAPK51.02540873
40CSNK1G31.02313544
41DYRK31.01903311
42VRK11.00161796
43TIE10.96375382
44MAP3K70.93016893
45CSNK1A1L0.92281315
46MKNK20.91879029
47PNCK0.91325268
48PTK60.90280202
49BLK0.86047235
50CAMK10.85194854
51SIK20.84884262
52MARK20.80818721
53STK160.80695893
54TNIK0.78758871
55CSNK1G20.76947935
56TYRO30.74391607
57CSNK1G10.70595268
58RPS6KA50.69024434
59NEK20.68694222
60STK380.65677699
61PLK40.65518497
62PRKCQ0.65029201
63CHEK20.64507029
64CAMK2G0.64408512
65BRSK20.63622137
66NME10.63164511
67WNK10.61527291
68NTRK20.61525565
69MAP3K20.61221827
70ALK0.60955947
71MAPKAPK30.60741571
72EPHB10.60629820
73CASK0.59256518
74OXSR10.59193825
75TAF10.58758261
76STK110.57971340
77NTRK30.57294045
78PLK10.56895483
79TRPM70.55947920
80PAK60.55728384
81MARK10.55311923
82VRK20.52658654
83PIK3CA0.49206603
84CAMK2D0.49188770
85PRKACA0.49132494
86RPS6KB20.48757691
87CAMK40.48479523
88PRKD20.48427240
89CAMK2B0.46803704
90PLK30.46414838
91STK390.46398545
92PRKCI0.44528139
93CDC70.44178892
94BMX0.44064609
95MAP3K90.42966171
96MINK10.41785181
97GRK70.39982197
98ATR0.39826381
99DYRK20.39710057
100PLK20.39612883
101CDK50.39441410
102PAK20.39319124
103DYRK1A0.39269148
104MKNK10.38458646
105CSNK1D0.37966288
106PRKCH0.37532250
107MAPK40.37266897
108EIF2AK30.36326608
109PRKCZ0.36081757
110FLT30.35230449
111PTK2B0.34141358
112TESK20.34042304
113ICK0.33763507
114PRKCE0.33569785
115PRKCA0.32368257
116PRKG20.32304933
117RPS6KA40.31684514
118UHMK10.31593342
119RPS6KA60.30899207
120HIPK20.29856476
121CSF1R0.29415186
122MELK0.29093893
123NTRK10.28870987
124PRKG10.28521166
125CDK190.27798815
126EPHA30.27343572
127CHUK0.27278451
128NLK0.27093173
129PASK0.26064218
130DAPK20.25263069
131CSNK1A10.25193477
132IKBKB0.25146085
133CDK90.24025736
134JAK20.23672266
135PAK30.22899912
136PHKG10.22692431
137PHKG20.22692431
138PIK3CG0.22614129
139ERBB20.22314964
140SGK4940.21893345
141SGK2230.21893345
142CAMK2A0.20992068
143BTK0.20105684
144FGFR10.17832134
145FER0.17741817
146PRKCG0.16712074
147TYK20.15257579
148DAPK10.14969904
149TTN0.12605926
150PDPK10.12593786
151GSK3A0.11939062
152CDK140.11477796
153ROCK20.11209599
154KIT0.11043840
155MAP2K10.10980644
156PRKACB0.10858011
157PRKAA10.10425973
158CDK150.10006039
159CDK40.09483539
160PRKCB0.08619315
161CDK180.08412297
162GRK50.08037666
163RPS6KB10.07735953
164PKN10.07307157
165MAPK100.07241686

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.04409740
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.79972816
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.75681014
4Linoleic acid metabolism_Homo sapiens_hsa005912.71881131
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.67223676
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.61995543
7Phototransduction_Homo sapiens_hsa047442.60761593
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.53627206
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.53021009
10Nitrogen metabolism_Homo sapiens_hsa009102.52862594
11Type II diabetes mellitus_Homo sapiens_hsa049302.48562760
12Parkinsons disease_Homo sapiens_hsa050122.41506303
13Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.28631749
14ErbB signaling pathway_Homo sapiens_hsa040122.27021476
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.20471259
16Ribosome_Homo sapiens_hsa030102.19318600
17GABAergic synapse_Homo sapiens_hsa047272.04209374
18NOD-like receptor signaling pathway_Homo sapiens_hsa046212.03022172
19Sulfur relay system_Homo sapiens_hsa041221.97646041
20Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.90418581
21GnRH signaling pathway_Homo sapiens_hsa049121.89477114
22Ether lipid metabolism_Homo sapiens_hsa005651.84934042
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.84856705
24Morphine addiction_Homo sapiens_hsa050321.79379422
25RNA polymerase_Homo sapiens_hsa030201.76929502
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.76702756
27Homologous recombination_Homo sapiens_hsa034401.75235668
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.74635872
29Huntingtons disease_Homo sapiens_hsa050161.73675948
30Glutamatergic synapse_Homo sapiens_hsa047241.71694966
31Fanconi anemia pathway_Homo sapiens_hsa034601.71183627
32Selenocompound metabolism_Homo sapiens_hsa004501.68792083
33Dopaminergic synapse_Homo sapiens_hsa047281.66202859
34Taste transduction_Homo sapiens_hsa047421.65121962
35Nicotine addiction_Homo sapiens_hsa050331.64580740
36Alzheimers disease_Homo sapiens_hsa050101.61144634
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.59910145
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58464872
39Pertussis_Homo sapiens_hsa051331.55992972
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.55921091
41One carbon pool by folate_Homo sapiens_hsa006701.54986628
42Protein export_Homo sapiens_hsa030601.52727815
43Tryptophan metabolism_Homo sapiens_hsa003801.52680333
44Circadian entrainment_Homo sapiens_hsa047131.50370299
45Sphingolipid signaling pathway_Homo sapiens_hsa040711.49780341
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.49496195
47Colorectal cancer_Homo sapiens_hsa052101.47387529
48Synaptic vesicle cycle_Homo sapiens_hsa047211.46943074
49Adipocytokine signaling pathway_Homo sapiens_hsa049201.46877403
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.43574717
51Prion diseases_Homo sapiens_hsa050201.39862759
52Axon guidance_Homo sapiens_hsa043601.30716811
53Salmonella infection_Homo sapiens_hsa051321.29874208
54Pancreatic cancer_Homo sapiens_hsa052121.29195545
55Cocaine addiction_Homo sapiens_hsa050301.26541337
56Gastric acid secretion_Homo sapiens_hsa049711.26247478
57Basal transcription factors_Homo sapiens_hsa030221.22647927
58Renin secretion_Homo sapiens_hsa049241.22385528
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20777611
60Choline metabolism in cancer_Homo sapiens_hsa052311.19835430
61Caffeine metabolism_Homo sapiens_hsa002321.17601890
62Gap junction_Homo sapiens_hsa045401.13995499
63Aldosterone synthesis and secretion_Homo sapiens_hsa049251.13826887
64Amphetamine addiction_Homo sapiens_hsa050311.13291955
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.13068219
66Prolactin signaling pathway_Homo sapiens_hsa049171.12032990
67Long-term potentiation_Homo sapiens_hsa047201.11571110
68cAMP signaling pathway_Homo sapiens_hsa040241.09990391
69Oxytocin signaling pathway_Homo sapiens_hsa049211.07149191
70Primary bile acid biosynthesis_Homo sapiens_hsa001201.05871250
71Fatty acid elongation_Homo sapiens_hsa000621.02900842
72RNA degradation_Homo sapiens_hsa030181.02775195
73Vitamin digestion and absorption_Homo sapiens_hsa049771.02181797
74Serotonergic synapse_Homo sapiens_hsa047260.96017821
75Chemical carcinogenesis_Homo sapiens_hsa052040.93032034
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92635455
77Arachidonic acid metabolism_Homo sapiens_hsa005900.91712262
78Calcium signaling pathway_Homo sapiens_hsa040200.90802382
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89086867
80Olfactory transduction_Homo sapiens_hsa047400.88370559
81Cholinergic synapse_Homo sapiens_hsa047250.87984843
82Insulin secretion_Homo sapiens_hsa049110.87660578
83Fat digestion and absorption_Homo sapiens_hsa049750.87268626
84FoxO signaling pathway_Homo sapiens_hsa040680.87096636
85Insulin resistance_Homo sapiens_hsa049310.86765254
86Hepatitis B_Homo sapiens_hsa051610.85748057
87Folate biosynthesis_Homo sapiens_hsa007900.85486258
88Shigellosis_Homo sapiens_hsa051310.83674301
89African trypanosomiasis_Homo sapiens_hsa051430.83049499
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82549434
91Butanoate metabolism_Homo sapiens_hsa006500.82321230
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.81733997
93Salivary secretion_Homo sapiens_hsa049700.81136991
94Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79281064
95Dilated cardiomyopathy_Homo sapiens_hsa054140.79199743
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78018264
97Wnt signaling pathway_Homo sapiens_hsa043100.77809150
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77310162
99ABC transporters_Homo sapiens_hsa020100.76885827
100Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75941166
101Arginine biosynthesis_Homo sapiens_hsa002200.75764198
102Primary immunodeficiency_Homo sapiens_hsa053400.75012473
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74865163
104Ovarian steroidogenesis_Homo sapiens_hsa049130.74585629
105Cardiac muscle contraction_Homo sapiens_hsa042600.74090444
106T cell receptor signaling pathway_Homo sapiens_hsa046600.73462556
107Rheumatoid arthritis_Homo sapiens_hsa053230.73098176
108Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.71508776
109Proteasome_Homo sapiens_hsa030500.71486897
110Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.70884699
111Intestinal immune network for IgA production_Homo sapiens_hsa046720.70552723
112Peroxisome_Homo sapiens_hsa041460.70404269
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.68284834
114Retinol metabolism_Homo sapiens_hsa008300.67731145
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67263430
116Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66318398
117Long-term depression_Homo sapiens_hsa047300.64167439
118Tuberculosis_Homo sapiens_hsa051520.63840509
119Propanoate metabolism_Homo sapiens_hsa006400.62434222
120Osteoclast differentiation_Homo sapiens_hsa043800.62041740
121Metabolic pathways_Homo sapiens_hsa011000.61189366
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61170166
123Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59878178
124Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59368085
125Purine metabolism_Homo sapiens_hsa002300.58989234
126Pyrimidine metabolism_Homo sapiens_hsa002400.58335147
127Complement and coagulation cascades_Homo sapiens_hsa046100.58234276
128Glycerolipid metabolism_Homo sapiens_hsa005610.57319933
129Bile secretion_Homo sapiens_hsa049760.55689339
130Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54986005
131Cysteine and methionine metabolism_Homo sapiens_hsa002700.53928585
132Pyruvate metabolism_Homo sapiens_hsa006200.53387884
133Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52231175
134Fatty acid degradation_Homo sapiens_hsa000710.50967808
135Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49934040
136Cyanoamino acid metabolism_Homo sapiens_hsa004600.49483928
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.49268954
138Steroid biosynthesis_Homo sapiens_hsa001000.47265486
139beta-Alanine metabolism_Homo sapiens_hsa004100.45680632
140Histidine metabolism_Homo sapiens_hsa003400.44979770
141Hedgehog signaling pathway_Homo sapiens_hsa043400.44152548
142Mineral absorption_Homo sapiens_hsa049780.43823645
143Fatty acid biosynthesis_Homo sapiens_hsa000610.43511669
144Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43466563
145B cell receptor signaling pathway_Homo sapiens_hsa046620.43332896
146Acute myeloid leukemia_Homo sapiens_hsa052210.43172298
147Basal cell carcinoma_Homo sapiens_hsa052170.42914426
148Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42772418
149Regulation of autophagy_Homo sapiens_hsa041400.42299669
150TNF signaling pathway_Homo sapiens_hsa046680.42230612
151Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41825140
152* Ras signaling pathway_Homo sapiens_hsa040140.41073730
153Vascular smooth muscle contraction_Homo sapiens_hsa042700.40957841
154Malaria_Homo sapiens_hsa051440.40711613
155Insulin signaling pathway_Homo sapiens_hsa049100.40237521
156Herpes simplex infection_Homo sapiens_hsa051680.40159863
157Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40135628
158Collecting duct acid secretion_Homo sapiens_hsa049660.39376102
159Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36545208
160Nucleotide excision repair_Homo sapiens_hsa034200.35950813
161Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34726971
162SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33027736
163Dorso-ventral axis formation_Homo sapiens_hsa043200.28935146
164Vitamin B6 metabolism_Homo sapiens_hsa007500.21741245
165RNA transport_Homo sapiens_hsa030130.21340041

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