FGF23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1doxorubicin metabolic process (GO:0044598)8.29472245
2daunorubicin metabolic process (GO:0044597)8.29472245
3polyketide metabolic process (GO:0030638)8.29472245
4behavioral response to nicotine (GO:0035095)6.52514057
5membrane repolarization during cardiac muscle cell action potential (GO:0086013)6.35381635
6regulation of DNA endoreduplication (GO:0032875)6.01422115
7membrane repolarization during action potential (GO:0086011)5.99932639
8membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.95833374
9parturition (GO:0007567)5.80859867
10establishment of protein localization to mitochondrial membrane (GO:0090151)5.26444271
11detection of molecule of bacterial origin (GO:0032490)5.25290607
12lymphangiogenesis (GO:0001946)5.24093296
13piRNA metabolic process (GO:0034587)5.20158596
14aminoglycoside antibiotic metabolic process (GO:0030647)5.00377553
15lymph vessel development (GO:0001945)4.93113319
16DNA methylation involved in gamete generation (GO:0043046)4.72073277
17regulation of meiosis I (GO:0060631)4.65268885
18positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)4.63647755
19membrane repolarization (GO:0086009)4.60352876
20male meiosis I (GO:0007141)4.59130853
21regulation of membrane repolarization (GO:0060306)4.47298714
22regulation of activation of Janus kinase activity (GO:0010533)4.44908576
23magnesium ion transport (GO:0015693)4.28273769
24negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.19524767
25positive regulation of potassium ion transmembrane transport (GO:1901381)4.06494480
26cellular potassium ion homeostasis (GO:0030007)3.99049468
27vascular endothelial growth factor signaling pathway (GO:0038084)3.98651900
28negative regulation of response to food (GO:0032096)3.96572982
29negative regulation of appetite (GO:0032099)3.96572982
30positive regulation of synapse maturation (GO:0090129)3.96461085
31detection of external biotic stimulus (GO:0098581)3.95790385
32positive regulation of protein kinase C signaling (GO:0090037)3.91856593
33regulation of potassium ion transmembrane transport (GO:1901379)3.89629912
34synapsis (GO:0007129)3.86494128
35positive regulation of meiosis (GO:0045836)3.85250582
36leukocyte tethering or rolling (GO:0050901)3.79421850
37negative regulation of potassium ion transmembrane transport (GO:1901380)3.76067155
38lateral ventricle development (GO:0021670)3.73421290
39venous blood vessel morphogenesis (GO:0048845)3.72691118
40pericardium development (GO:0060039)3.71807291
41regulation of RIG-I signaling pathway (GO:0039535)3.67439507
42regulation of skeletal muscle contraction (GO:0014819)3.66814333
43response to pheromone (GO:0019236)3.64882234
44positive regulation of astrocyte differentiation (GO:0048711)3.62161733
45cellular response to electrical stimulus (GO:0071257)3.61141411
46positive regulation of meiotic cell cycle (GO:0051446)3.59081615
47cell migration involved in heart development (GO:0060973)3.54317614
48neuron remodeling (GO:0016322)3.52012702
49positive regulation vascular endothelial growth factor production (GO:0010575)3.51341617
50chromosome organization involved in meiosis (GO:0070192)3.50862513
51negative regulation of DNA-dependent DNA replication (GO:2000104)3.50363763
52regulation of mesoderm development (GO:2000380)3.47497903
53regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.47320396
54regulation of synapse maturation (GO:0090128)3.43556718
55synaptonemal complex assembly (GO:0007130)3.40090865
56positive regulation of cellular amide metabolic process (GO:0034250)3.39284709
57interleukin-6-mediated signaling pathway (GO:0070102)3.39205336
58leukocyte migration involved in inflammatory response (GO:0002523)3.36437207
59meiosis I (GO:0007127)3.35913168
60histone H4-K12 acetylation (GO:0043983)3.32254820
61detection of biotic stimulus (GO:0009595)3.27703684
62regulation of fever generation (GO:0031620)3.26062591
63potassium ion import (GO:0010107)3.25625603
64cell proliferation in forebrain (GO:0021846)3.22949469
65energy homeostasis (GO:0097009)3.22918402
66regulation of glomerulus development (GO:0090192)3.22236306
67antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.22228627
68somite development (GO:0061053)3.21628770
69male meiosis (GO:0007140)3.18724473
70ovulation cycle (GO:0042698)3.18272114
71regulation of potassium ion transmembrane transporter activity (GO:1901016)3.18184655
72synaptonemal complex organization (GO:0070193)3.16871407
73auditory receptor cell stereocilium organization (GO:0060088)3.13770821
74regulation of vascular endothelial growth factor production (GO:0010574)3.12685152
75DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.10788886
76regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.09749646
77negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.08949299
78negative regulation of viral genome replication (GO:0045071)3.03772311
79negative regulation of gene silencing (GO:0060969)3.02941851
80dendritic cell chemotaxis (GO:0002407)3.02495669
81positive regulation of interferon-alpha production (GO:0032727)3.01778941
82regulation of heart rate by cardiac conduction (GO:0086091)3.01762357
83tachykinin receptor signaling pathway (GO:0007217)2.99090413
84regulation of posttranscriptional gene silencing (GO:0060147)2.97484923
85regulation of gene silencing by miRNA (GO:0060964)2.97484923
86regulation of gene silencing by RNA (GO:0060966)2.97484923
87sex differentiation (GO:0007548)2.95505309
88transmission of nerve impulse (GO:0019226)2.95287638
89positive regulation of potassium ion transport (GO:0043268)2.93325369
90sister chromatid cohesion (GO:0007062)2.92681776
91serotonin metabolic process (GO:0042428)2.92490448
92regulation of response to food (GO:0032095)2.92401642
93phosphorelay signal transduction system (GO:0000160)2.92256400
94atrioventricular valve morphogenesis (GO:0003181)2.92186803
95negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.91578533
96mitochondrial respiratory chain complex I assembly (GO:0032981)2.90290426
97NADH dehydrogenase complex assembly (GO:0010257)2.90290426
98mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.90290426
99cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.87751759
100detection of other organism (GO:0098543)2.85475764
101regulation of potassium ion transport (GO:0043266)2.85159866
102neurofilament cytoskeleton organization (GO:0060052)2.85045077
103membrane depolarization during action potential (GO:0086010)2.84889417
104striatum development (GO:0021756)2.84629196
105ganglion development (GO:0061548)2.84553284
106positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.84102013
107negative regulation of protein localization to cell surface (GO:2000009)2.83223034
108regulation of chromatin binding (GO:0035561)2.82288840
109type I interferon signaling pathway (GO:0060337)2.81771513
110cellular response to type I interferon (GO:0071357)2.81771513
111response to electrical stimulus (GO:0051602)2.80683390
112eosinophil chemotaxis (GO:0048245)2.79307975
113positive regulation of male gonad development (GO:2000020)2.78490789
114negative regulation of homotypic cell-cell adhesion (GO:0034111)2.78175624
115regulation of interferon-alpha production (GO:0032647)2.77520946
116retinal ganglion cell axon guidance (GO:0031290)2.77238893
117mRNA transcription from RNA polymerase II promoter (GO:0042789)2.76961261
118regulation of cellular extravasation (GO:0002691)2.76320156
119negative regulation of systemic arterial blood pressure (GO:0003085)2.75602281
120gamma-aminobutyric acid transport (GO:0015812)2.75074373
121response to type I interferon (GO:0034340)2.75006630
122cellular response to virus (GO:0098586)2.73204182
123chaperone-mediated protein complex assembly (GO:0051131)2.72697924
124endoderm formation (GO:0001706)2.72589851
125regulation of cell proliferation involved in kidney development (GO:1901722)2.72214829
126endothelium development (GO:0003158)2.71160479
127negative regulation of transcription regulatory region DNA binding (GO:2000678)2.70377061
128positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.70189857
129protein localization to synapse (GO:0035418)2.69192628
130ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.68227604
131primary amino compound metabolic process (GO:1901160)2.68214716
132sulfation (GO:0051923)2.68070392
133protein complex biogenesis (GO:0070271)2.67739538
134positive regulation of uterine smooth muscle contraction (GO:0070474)2.67694088
135positive regulation of heat generation (GO:0031652)2.67686852
136multicellular organismal signaling (GO:0035637)2.67629534
137DNA damage response, signal transduction resulting in transcription (GO:0042772)2.67403320
138mesenchymal cell differentiation involved in kidney development (GO:0072161)2.67282452
139mesenchymal cell differentiation involved in renal system development (GO:2001012)2.67282452
140regulation of pigment cell differentiation (GO:0050932)2.67076274
141interferon-gamma production (GO:0032609)2.66694312
142dendritic cell migration (GO:0036336)2.66597637
143cellular response to thyroid hormone stimulus (GO:0097067)2.65690272
144T-helper 1 type immune response (GO:0042088)2.65034739
145embryonic body morphogenesis (GO:0010172)2.64181846
146positive regulation of acute inflammatory response (GO:0002675)2.63087705
147water-soluble vitamin biosynthetic process (GO:0042364)2.62783988
148reciprocal meiotic recombination (GO:0007131)2.61718009
149reciprocal DNA recombination (GO:0035825)2.61718009
150regulation of dendritic cell antigen processing and presentation (GO:0002604)2.60161478
151sulfate transmembrane transport (GO:1902358)2.59935475
152regulation of heat generation (GO:0031650)2.58527259
153nonmotile primary cilium assembly (GO:0035058)2.57089374
154otic vesicle formation (GO:0030916)2.56641657
155interkinetic nuclear migration (GO:0022027)2.56149522
156mRNA transcription (GO:0009299)2.55912812
157regulation of integrin activation (GO:0033623)2.55883963
158protein polyglutamylation (GO:0018095)2.55266078
159spinal cord development (GO:0021510)2.55079403
160protein localization to cilium (GO:0061512)2.53727445
161detection of bacterium (GO:0016045)2.53433224
162axon extension involved in axon guidance (GO:0048846)2.53396492
163neuron projection extension involved in neuron projection guidance (GO:1902284)2.53396492
164cellular response to exogenous dsRNA (GO:0071360)2.53299246
165regulation of collateral sprouting (GO:0048670)2.52966291
166regulation of receptor internalization (GO:0002090)2.51238280
167positive regulation of fatty acid oxidation (GO:0046321)2.50583949
168negative regulation of platelet activation (GO:0010544)2.48655206
169synaptic transmission, cholinergic (GO:0007271)2.48571532
170negative regulation of osteoblast proliferation (GO:0033689)2.47810848
171negative regulation of sodium ion transport (GO:0010766)2.46763068
172meiotic nuclear division (GO:0007126)2.45757866
173snRNA transcription (GO:0009301)2.45662777
174regulation of female receptivity (GO:0045924)2.45214890
175positive regulation of natural killer cell differentiation (GO:0032825)2.45150550
176atrial septum morphogenesis (GO:0060413)2.44275342
177substrate-independent telencephalic tangential migration (GO:0021826)2.43288772
178substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.43288772
179regulation of interleukin-8 secretion (GO:2000482)2.41928751
180negative regulation of protein autophosphorylation (GO:0031953)2.40827139
181tyrosine phosphorylation of STAT protein (GO:0007260)2.40057898
182cellular response to interferon-beta (GO:0035458)2.39830512
183superoxide anion generation (GO:0042554)2.39577653
184regulation of T-helper 1 cell differentiation (GO:0045625)2.37625282
185eosinophil migration (GO:0072677)2.37344781
186response to interferon-beta (GO:0035456)2.37295591
187positive regulation of vascular permeability (GO:0043117)2.37197765
188surfactant homeostasis (GO:0043129)2.36568762
189facial nerve structural organization (GO:0021612)2.34083315
190retina vasculature morphogenesis in camera-type eye (GO:0061299)2.32818798
191monocyte chemotaxis (GO:0002548)2.32462865
192positive regulation of antigen processing and presentation (GO:0002579)2.32379524
193neutrophil activation (GO:0042119)2.30246456
194positive regulation of receptor internalization (GO:0002092)2.30245347
195cardiac chamber formation (GO:0003207)2.29356865
196cranial nerve structural organization (GO:0021604)2.29214197
197response to peptidoglycan (GO:0032494)2.28612801
198response to interferon-alpha (GO:0035455)2.28524190
199granulocyte activation (GO:0036230)2.26099759
200positive regulation of type 2 immune response (GO:0002830)2.25990983

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human9.14641706
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.89328970
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.52045909
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.26002579
5SMAD_19615063_ChIP-ChIP_OVARY_Human3.01324111
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.81769042
7VDR_22108803_ChIP-Seq_LS180_Human2.66991889
8GBX2_23144817_ChIP-Seq_PC3_Human2.60473517
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.51121589
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.49630094
11RNF2_27304074_Chip-Seq_NSC_Mouse2.25201612
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.24293509
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.16992394
14ZNF274_21170338_ChIP-Seq_K562_Hela2.16068050
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.08048449
16REST_21632747_ChIP-Seq_MESCs_Mouse2.02846777
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.01123538
18EED_16625203_ChIP-ChIP_MESCs_Mouse1.99518359
19EWS_26573619_Chip-Seq_HEK293_Human1.93873767
20VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.89543844
21ZFP57_27257070_Chip-Seq_ESCs_Mouse1.87129712
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.82975024
23GATA2_21666600_ChIP-Seq_HMVEC_Human1.81514270
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80640328
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.75166341
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73386968
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.72808724
28IRF1_19129219_ChIP-ChIP_H3396_Human1.67000592
29KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.66512256
30KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.66512256
31KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.66512256
32IGF1R_20145208_ChIP-Seq_DFB_Human1.66043995
33EZH2_22144423_ChIP-Seq_EOC_Human1.63742935
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.61196631
35SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.60292958
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.60123622
37AR_21572438_ChIP-Seq_LNCaP_Human1.59286024
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.57255944
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57100000
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.54176758
41TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53578566
42POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.53578566
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51109017
44JARID2_20064375_ChIP-Seq_MESCs_Mouse1.47875262
45REST_18959480_ChIP-ChIP_MESCs_Mouse1.47153342
46JARID2_20075857_ChIP-Seq_MESCs_Mouse1.46944804
47SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.45748099
48IRF8_27001747_Chip-Seq_BMDM_Mouse1.45236980
49P300_19829295_ChIP-Seq_ESCs_Human1.44917270
50EZH2_18974828_ChIP-Seq_MESCs_Mouse1.44026203
51RNF2_18974828_ChIP-Seq_MESCs_Mouse1.44026203
52FUS_26573619_Chip-Seq_HEK293_Human1.43526139
53VDR_24787735_ChIP-Seq_THP-1_Human1.43005993
54E2F1_18555785_Chip-Seq_ESCs_Mouse1.42169952
55EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.40909312
56ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.40521013
57* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39813879
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39077538
59TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.38997660
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38242060
61RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.37254280
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37195676
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34452680
64STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.34252931
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32551128
66RXR_22108803_ChIP-Seq_LS180_Human1.32296414
67BCAT_22108803_ChIP-Seq_LS180_Human1.31993243
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.31638312
69NANOG_18555785_Chip-Seq_ESCs_Mouse1.30998137
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30843380
71Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29818029
72PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29305061
73CMYC_18555785_Chip-Seq_ESCs_Mouse1.29080129
74CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.28452715
75* EZH2_27294783_Chip-Seq_ESCs_Mouse1.28275218
76TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28081911
77SUZ12_18555785_Chip-Seq_ESCs_Mouse1.27854338
78MYC_18940864_ChIP-ChIP_HL60_Human1.27751689
79DROSHA_22980978_ChIP-Seq_HELA_Human1.27542939
80SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27145740
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26636212
82RNF2_27304074_Chip-Seq_ESCs_Mouse1.26336677
83CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25272426
84P53_22387025_ChIP-Seq_ESCs_Mouse1.25166679
85EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23905519
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23872885
87RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.23723525
88EZH2_27304074_Chip-Seq_ESCs_Mouse1.23328796
89* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.22858488
90STAT3_23295773_ChIP-Seq_U87_Human1.22464564
91STAT3_18555785_Chip-Seq_ESCs_Mouse1.20914623
92CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20822352
93TCF4_23295773_ChIP-Seq_U87_Human1.19968964
94NFE2_27457419_Chip-Seq_LIVER_Mouse1.19107355
95FLI1_27457419_Chip-Seq_LIVER_Mouse1.18980956
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17563144
97BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15768501
98TCF4_18268006_ChIP-ChIP_LS174T_Human1.15291229
99NMYC_18555785_Chip-Seq_ESCs_Mouse1.14690950
100IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14200318
101CBP_20019798_ChIP-Seq_JUKART_Human1.14200318
102TAF15_26573619_Chip-Seq_HEK293_Human1.14065539
103MTF2_20144788_ChIP-Seq_MESCs_Mouse1.13937042
104RING1B_27294783_Chip-Seq_ESCs_Mouse1.13660529
105ESR1_20079471_ChIP-ChIP_T-47D_Human1.13425747
106* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13347069
107SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12546964
108EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.11706689
109GATA1_26923725_Chip-Seq_HPCs_Mouse1.11664005
110POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11419404
111SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.10727575
112TDRD3_21172665_ChIP-Seq_MCF-7_Human1.10249309
113TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10244758
114P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10153975
115PIAS1_25552417_ChIP-Seq_VCAP_Human1.07807436
116CJUN_26792858_Chip-Seq_BT549_Human1.07573618
117OCT4_18555785_Chip-Seq_ESCs_Mouse1.07559429
118SMAD3_21741376_ChIP-Seq_ESCs_Human1.07257752
119SMAD4_21799915_ChIP-Seq_A2780_Human1.06169921
120ER_23166858_ChIP-Seq_MCF-7_Human1.05803810
121RUNX1_27457419_Chip-Seq_LIVER_Mouse1.05657954
122ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05380312
123TP53_18474530_ChIP-ChIP_U2OS_Human1.05364177
124TAL1_26923725_Chip-Seq_HPCs_Mouse1.05350632
125PU1_27457419_Chip-Seq_LIVER_Mouse1.05029887
126TP53_20018659_ChIP-ChIP_R1E_Mouse1.04605525
127P300_18555785_Chip-Seq_ESCs_Mouse1.04157126
128ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03987286
129RUNX2_22187159_ChIP-Seq_PCA_Human1.03416467
130RUNX_20019798_ChIP-Seq_JUKART_Human1.02953715
131CBX2_27304074_Chip-Seq_ESCs_Mouse1.02705041
132NCOR_22424771_ChIP-Seq_293T_Human1.02043070
133PRDM14_20953172_ChIP-Seq_ESCs_Human1.01733251
134SOX2_18555785_Chip-Seq_ESCs_Mouse1.01535695
135ZFX_18555785_Chip-Seq_ESCs_Mouse1.01036739
136SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00176988
137SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99928103
138HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.99497345
139TP63_19390658_ChIP-ChIP_HaCaT_Human0.99211124
140AR_25329375_ChIP-Seq_VCAP_Human0.98174159
141* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.96928912
142CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.96856301
143STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.96487310
144RING1B_27294783_Chip-Seq_NPCs_Mouse0.96073620
145ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95439113
146PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94933501
147FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94860076
148AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94738234
149* FOXA1_25329375_ChIP-Seq_VCAP_Human0.94709756
150* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94709756
151TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94455455
152KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94288986
153SMAD3_21741376_ChIP-Seq_EPCs_Human0.94047317
154PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92595312
155CTCF_18555785_Chip-Seq_ESCs_Mouse0.91955082
156ESRRB_18555785_Chip-Seq_ESCs_Mouse0.91079675
157JUN_21703547_ChIP-Seq_K562_Human0.88256310
158BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87818150
159* TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.87670744

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to6.12487005
2MP0008004_abnormal_stomach_pH6.10942990
3MP0008877_abnormal_DNA_methylation4.64221245
4MP0010368_abnormal_lymphatic_system4.15001364
5MP0001879_abnormal_lymphatic_vessel3.77088751
6MP0006054_spinal_hemorrhage3.31510600
7MP0003646_muscle_fatigue3.21126253
8MP0003941_abnormal_skin_development2.70744270
9MP0002148_abnormal_hypersensitivity_rea2.69602338
10MP0003123_paternal_imprinting2.60127431
11MP0004885_abnormal_endolymph2.40336987
12MP0000566_synostosis2.36764293
13MP0005167_abnormal_blood-brain_barrier2.30867363
14MP0003136_yellow_coat_color2.28562625
15MP0003787_abnormal_imprinting2.19925314
16MP0002653_abnormal_ependyma_morphology2.19389197
17MP0001835_abnormal_antigen_presentation2.14850410
18MP0001986_abnormal_taste_sensitivity2.10488388
19MP0001440_abnormal_grooming_behavior2.08039034
20* MP0002160_abnormal_reproductive_system2.06107121
21MP0002272_abnormal_nervous_system2.02894052
22MP0002163_abnormal_gland_morphology1.99407886
23MP0005409_darkened_coat_color1.98416526
24MP0002837_dystrophic_cardiac_calcinosis1.97898823
25MP0002277_abnormal_respiratory_mucosa1.94146283
26MP0001851_eye_inflammation1.93667739
27MP0003880_abnormal_central_pattern1.93325100
28* MP0005389_reproductive_system_phenotype1.92807645
29MP0004142_abnormal_muscle_tone1.89960854
30MP0003121_genomic_imprinting1.89923676
31MP0009785_altered_susceptibility_to1.88826910
32MP0000778_abnormal_nervous_system1.87293012
33MP0003890_abnormal_embryonic-extraembry1.83965857
34MP0005377_hearing/vestibular/ear_phenot1.83126722
35MP0003878_abnormal_ear_physiology1.83126722
36MP0009697_abnormal_copulation1.82361753
37MP0005423_abnormal_somatic_nervous1.81174390
38MP0009379_abnormal_foot_pigmentation1.78724207
39MP0001485_abnormal_pinna_reflex1.78373688
40MP0004130_abnormal_muscle_cell1.75540442
41MP0002210_abnormal_sex_determination1.72575783
42MP0009745_abnormal_behavioral_response1.71665316
43MP0004145_abnormal_muscle_electrophysio1.70871768
44MP0006276_abnormal_autonomic_nervous1.70093476
45MP0002184_abnormal_innervation1.66895367
46MP0001919_abnormal_reproductive_system1.66872953
47MP0005310_abnormal_salivary_gland1.62408167
48MP0004782_abnormal_surfactant_physiolog1.62235841
49MP0000569_abnormal_digit_pigmentation1.61899838
50MP0000631_abnormal_neuroendocrine_gland1.60641298
51MP0002396_abnormal_hematopoietic_system1.59991815
52MP0003315_abnormal_perineum_morphology1.57531721
53MP0002419_abnormal_innate_immunity1.55048126
54MP0004510_myositis1.53672993
55MP0003828_pulmonary_edema1.52444025
56MP0002138_abnormal_hepatobiliary_system1.51544691
57MP0002063_abnormal_learning/memory/cond1.51479739
58MP0004133_heterotaxia1.49894672
59MP0005387_immune_system_phenotype1.49867860
60MP0001790_abnormal_immune_system1.49867860
61MP0001348_abnormal_lacrimal_gland1.48913054
62MP0005551_abnormal_eye_electrophysiolog1.47868357
63MP0001188_hyperpigmentation1.47201399
64MP0003635_abnormal_synaptic_transmissio1.46352685
65MP0005000_abnormal_immune_tolerance1.46232374
66MP0009046_muscle_twitch1.45688346
67MP0003119_abnormal_digestive_system1.42704314
68MP0003122_maternal_imprinting1.42011460
69MP0002736_abnormal_nociception_after1.41290525
70MP0001145_abnormal_male_reproductive1.41216687
71MP0002064_seizures1.38745403
72MP0005025_abnormal_response_to1.36676188
73MP0005671_abnormal_response_to1.36482057
74MP0001533_abnormal_skeleton_physiology1.35447788
75MP0006292_abnormal_olfactory_placode1.32836645
76MP0001346_abnormal_lacrimal_gland1.31960933
77MP0009278_abnormal_bone_marrow1.31322851
78MP0002254_reproductive_system_inflammat1.30215969
79MP0000955_abnormal_spinal_cord1.29377180
80MP0000049_abnormal_middle_ear1.28304746
81MP0000653_abnormal_sex_gland1.28226219
82MP0005645_abnormal_hypothalamus_physiol1.27620150
83MP0009764_decreased_sensitivity_to1.27523758
84MP0003942_abnormal_urinary_system1.27226339
85MP0003567_abnormal_fetal_cardiomyocyte1.26795449
86MP0003937_abnormal_limbs/digits/tail_de1.26421144
87MP0002733_abnormal_thermal_nociception1.25224765
88MP0000372_irregular_coat_pigmentation1.24336244
89MP0002572_abnormal_emotion/affect_behav1.21594058
90MP0001929_abnormal_gametogenesis1.21412532
91MP0003698_abnormal_male_reproductive1.20722060
92MP0008995_early_reproductive_senescence1.19147261
93MP0001970_abnormal_pain_threshold1.19126815
94MP0005397_hematopoietic_system_phenotyp1.17798481
95MP0001545_abnormal_hematopoietic_system1.17798481
96MP0002734_abnormal_mechanical_nocicepti1.17732338
97MP0002723_abnormal_immune_serum1.16196386
98MP0005171_absent_coat_pigmentation1.15981640
99MP0003300_gastrointestinal_ulcer1.15233939
100MP0004215_abnormal_myocardial_fiber1.13795388
101MP0002735_abnormal_chemical_nociception1.13659344
102MP0002998_abnormal_bone_remodeling1.13547987
103MP0004858_abnormal_nervous_system1.13486224
104MP0002067_abnormal_sensory_capabilities1.13060706
105MP0008789_abnormal_olfactory_epithelium1.12956153
106MP0001502_abnormal_circadian_rhythm1.12656048
107MP0002452_abnormal_antigen_presenting1.11796737
108MP0002557_abnormal_social/conspecific_i1.10722788
109MP0003879_abnormal_hair_cell1.09931421
110MP0003303_peritoneal_inflammation1.09916004
111MP0002752_abnormal_somatic_nervous1.09693845
112MP0002933_joint_inflammation1.08760017
113MP0000427_abnormal_hair_cycle1.08396795
114MP0005379_endocrine/exocrine_gland_phen1.08337993
115MP0000013_abnormal_adipose_tissue1.07463762
116MP0010155_abnormal_intestine_physiology1.06623856
117MP0001800_abnormal_humoral_immune1.05270833
118MP0003938_abnormal_ear_development1.05080798
119MP0009250_abnormal_appendicular_skeleto1.04629193
120MP0009053_abnormal_anal_canal1.04129845
121MP0002882_abnormal_neuron_morphology1.03611242
122MP0005410_abnormal_fertilization1.02932015
123MP0003436_decreased_susceptibility_to1.01874237
124MP0001873_stomach_inflammation1.01259049
125MP0000026_abnormal_inner_ear1.01202720
126MP0000767_abnormal_smooth_muscle1.00974570
127MP0002127_abnormal_cardiovascular_syste1.00782520
128MP0003011_delayed_dark_adaptation0.99860230
129MP0002132_abnormal_respiratory_system0.99345946
130MP0005390_skeleton_phenotype0.98846556
131MP0006072_abnormal_retinal_apoptosis0.98587874
132MP0003191_abnormal_cellular_cholesterol0.96881553
133MP0004808_abnormal_hematopoietic_stem0.95003148
134MP0004272_abnormal_basement_membrane0.94414922
135MP0001819_abnormal_immune_cell0.94355988
136MP0001764_abnormal_homeostasis0.94312331
137MP0005646_abnormal_pituitary_gland0.93573215
138MP0000685_abnormal_immune_system0.93388330
139MP0008872_abnormal_physiological_respon0.91306686
140MP0002152_abnormal_brain_morphology0.90802379
141MP0002420_abnormal_adaptive_immunity0.90771083
142MP0004859_abnormal_synaptic_plasticity0.90644801
143MP0001963_abnormal_hearing_physiology0.90582884
144MP0002102_abnormal_ear_morphology0.89844095
145MP0000230_abnormal_systemic_arterial0.89743483
146MP0004085_abnormal_heartbeat0.89609796
147MP0002638_abnormal_pupillary_reflex0.89056757
148MP0005195_abnormal_posterior_eye0.89024780
149MP0005174_abnormal_tail_pigmentation0.87614182
150MP0001968_abnormal_touch/_nociception0.87240779
151MP0001293_anophthalmia0.86436505
152MP0001905_abnormal_dopamine_level0.85796543
153MP0004134_abnormal_chest_morphology0.85694834
154MP0002405_respiratory_system_inflammati0.84755057
155MP0002928_abnormal_bile_duct0.83975661
156MP0003861_abnormal_nervous_system0.83896977
157MP0002006_tumorigenesis0.83749264
158MP0004883_abnormal_blood_vessel0.82298358
159MP0005257_abnormal_intraocular_pressure0.82130507
160MP0002009_preneoplasia0.81554590
161MP0002229_neurodegeneration0.81360791
162MP0003045_fibrosis0.81095555
163MP0002876_abnormal_thyroid_physiology0.80879754
164MP0003936_abnormal_reproductive_system0.80036831
165MP0005164_abnormal_response_to0.79975454
166MP0001845_abnormal_inflammatory_respons0.79697029
167MP0000343_altered_response_to0.79604199
168MP0003763_abnormal_thymus_physiology0.78071406
169MP0001486_abnormal_startle_reflex0.77604763
170MP0010386_abnormal_urinary_bladder0.76689944
171MP0005451_abnormal_body_composition0.76344448
172MP0005394_taste/olfaction_phenotype0.75813693
173MP0005499_abnormal_olfactory_system0.75813693
174MP0005503_abnormal_tendon_morphology0.73738476
175MP0005670_abnormal_white_adipose0.73310873
176MP0000678_abnormal_parathyroid_gland0.68378524
177MP0001853_heart_inflammation0.68214598
178MP0004742_abnormal_vestibular_system0.68117635
179MP0000249_abnormal_blood_vessel0.67998815
180MP0009333_abnormal_splenocyte_physiolog0.67164575
181MP0005508_abnormal_skeleton_morphology0.66977950
182MP0000465_gastrointestinal_hemorrhage0.66648742
183MP0005595_abnormal_vascular_smooth0.65788230
184MP0003385_abnormal_body_wall0.63169633
185MP0006082_CNS_inflammation0.62828326
186MP0000681_abnormal_thyroid_gland0.61820737

Predicted human phenotypes

RankGene SetZ-score
1Nonimmune hydrops fetalis (HP:0001790)4.69626519
2Retrobulbar optic neuritis (HP:0100654)4.60333493
3Optic neuritis (HP:0100653)4.60333493
4Orchitis (HP:0100796)4.52104692
5Absent eyebrow (HP:0002223)4.42926467
6Myositis (HP:0100614)4.04254097
7Absent eyelashes (HP:0000561)3.73426924
8Alopecia of scalp (HP:0002293)3.71600121
9Follicular hyperkeratosis (HP:0007502)3.61931580
10Anomalous pulmonary venous return (HP:0010772)3.61348999
11Nephronophthisis (HP:0000090)3.56614216
12Abnormality of midbrain morphology (HP:0002418)3.45979262
13Molar tooth sign on MRI (HP:0002419)3.45979262
14Unilateral renal agenesis (HP:0000122)3.44746776
15True hermaphroditism (HP:0010459)3.43344846
16Parakeratosis (HP:0001036)3.32702895
17Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.21901917
18Degeneration of the lateral corticospinal tracts (HP:0002314)3.21901917
19Chronic otitis media (HP:0000389)3.19848882
20Joint hemorrhage (HP:0005261)3.12408694
21Increased IgM level (HP:0003496)3.12105933
22Abnormality of the corticospinal tract (HP:0002492)3.07352603
23Cheilitis (HP:0100825)3.07008855
24Bilateral sensorineural hearing impairment (HP:0008619)3.06820784
25Abnormality of the renal medulla (HP:0100957)3.02374512
26Progressive cerebellar ataxia (HP:0002073)3.00918650
27Abnormality of the pulmonary veins (HP:0011718)3.00723257
28Capillary hemangiomas (HP:0005306)2.96049558
29Pancreatic fibrosis (HP:0100732)2.92728158
30Alveolar cell carcinoma (HP:0006519)2.90271886
31Genetic anticipation (HP:0003743)2.88134463
32Male pseudohermaphroditism (HP:0000037)2.84186593
33Aplasia cutis congenita (HP:0001057)2.83376121
34Pancreatic cysts (HP:0001737)2.76254181
35Septo-optic dysplasia (HP:0100842)2.75772988
36Abnormality of cells of the erythroid lineage (HP:0012130)2.74340882
37Abnormal biliary tract physiology (HP:0012439)2.70031099
38Bile duct proliferation (HP:0001408)2.70031099
39Spontaneous hematomas (HP:0007420)2.68373012
40Elevated erythrocyte sedimentation rate (HP:0003565)2.65839760
41Hemoptysis (HP:0002105)2.65012011
42Small hand (HP:0200055)2.64787236
43Hypoplasia of the fovea (HP:0007750)2.63606934
44Aplasia/Hypoplasia of the fovea (HP:0008060)2.63606934
45Prostate neoplasm (HP:0100787)2.60504229
46White forelock (HP:0002211)2.59475811
47Keratoconjunctivitis sicca (HP:0001097)2.59319721
48Abnormality of the renal collecting system (HP:0004742)2.59291015
49Abnormality of dental color (HP:0011073)2.57933988
50Ectropion (HP:0000656)2.57882994
51Abnormal number of erythroid precursors (HP:0012131)2.56907240
52Congenital stationary night blindness (HP:0007642)2.55691226
53Aplasia of the musculature (HP:0100854)2.53381693
54Tetraparesis (HP:0002273)2.52955789
55Neoplasm of the tracheobronchial system (HP:0100552)2.52290907
56Chromosomal breakage induced by crosslinking agents (HP:0003221)2.52201115
57Medial flaring of the eyebrow (HP:0010747)2.51953950
58Broad metatarsal (HP:0001783)2.51622829
59Oligodontia (HP:0000677)2.50278025
60Short femoral neck (HP:0100864)2.49633079
61Patchy hypopigmentation of hair (HP:0011365)2.48948271
62Pulmonary artery stenosis (HP:0004415)2.48798321
63Vasculitis (HP:0002633)2.48754524
64Hypoplasia of the uterus (HP:0000013)2.48296988
65Arterial thrombosis (HP:0004420)2.47078424
66Abnormality of the pleura (HP:0002103)2.42565218
67Chromsome breakage (HP:0040012)2.41567866
68Duplication of thumb phalanx (HP:0009942)2.40387566
69Portal hypertension (HP:0001409)2.39927580
70Keratitis (HP:0000491)2.38316882
71Keratoconjunctivitis (HP:0001096)2.38178512
72Abnormality of the hepatic vasculature (HP:0006707)2.35852740
73Absent hair (HP:0002298)2.33662264
74Clumsiness (HP:0002312)2.33110513
75Abnormality of the pericardium (HP:0001697)2.30699300
76Gait imbalance (HP:0002141)2.30563491
77Hypoplastic left heart (HP:0004383)2.29819476
78Short hallux (HP:0010109)2.29787050
79Volvulus (HP:0002580)2.26958026
80Petechiae (HP:0000967)2.26465768
81Polycythemia (HP:0001901)2.23952463
82Chronic sinusitis (HP:0011109)2.23447250
83Abnormality of the middle phalanges of the toes (HP:0010183)2.22962855
84Hematochezia (HP:0002573)2.22189699
85Porencephaly (HP:0002132)2.21120430
86Lymphedema (HP:0001004)2.20760503
87Pulmonary embolism (HP:0002204)2.20142742
88Preauricular pit (HP:0004467)2.19357809
89Periauricular skin pits (HP:0100277)2.19357809
90Megalencephaly (HP:0001355)2.19205767
91Abnormal delayed hypersensitivity skin test (HP:0002963)2.18800559
92Abolished electroretinogram (ERG) (HP:0000550)2.17947549
93Abnormality of the proximal phalanges of the hand (HP:0009834)2.17846880
94Recurrent corneal erosions (HP:0000495)2.17625883
95Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.17596703
96Mediastinal lymphadenopathy (HP:0100721)2.16606181
97Purpura (HP:0000979)2.15999641
98Accelerated skeletal maturation (HP:0005616)2.15425052
99Abnormality of the phalanges of the 5th finger (HP:0004213)2.15363891
100Recurrent abscess formation (HP:0002722)2.15093722
101Impaired vibration sensation in the lower limbs (HP:0002166)2.14358696
102Aplasia/Hypoplasia of the tibia (HP:0005772)2.13707302
103Abnormality of DNA repair (HP:0003254)2.13245516
104Congenital, generalized hypertrichosis (HP:0004540)2.12488370
105Congenital primary aphakia (HP:0007707)2.12431121
106Abnormality of the phalanges of the 2nd finger (HP:0009541)2.11655408
107Preaxial foot polydactyly (HP:0001841)2.09165072
108Anencephaly (HP:0002323)2.08422186
109Sclerocornea (HP:0000647)2.08391905
110Aplasia/Hypoplasia of the spleen (HP:0010451)2.07952698
111Rib fusion (HP:0000902)2.07870908
112Nephrogenic diabetes insipidus (HP:0009806)2.07838892
113Ectopic kidney (HP:0000086)2.07814652
114Hyperglycinemia (HP:0002154)2.07435605
115Decreased circulating renin level (HP:0003351)2.06551966
116Broad-based gait (HP:0002136)2.06524430
117Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.05681077
118Asplenia (HP:0001746)2.05607157
119Hypoplasia of the pons (HP:0012110)2.05486384
120Pulmonary infiltrates (HP:0002113)2.05335045
121Meningitis (HP:0001287)2.04509646
122Atrial fibrillation (HP:0005110)2.03672926
123Specific learning disability (HP:0001328)2.02597639
124Mitral stenosis (HP:0001718)2.02436274
125Basal ganglia calcification (HP:0002135)2.01855997
126Hypoplastic heart (HP:0001961)2.00494033
127Cystic liver disease (HP:0006706)2.00289334
128Polyphagia (HP:0002591)2.00273627
129Abnormal pancreas size (HP:0012094)1.99600632
130Partial duplication of thumb phalanx (HP:0009944)1.98796442
131Abnormality of the pons (HP:0007361)1.97162253
132Congenital sensorineural hearing impairment (HP:0008527)1.96684885
133* Hyperphosphatemia (HP:0002905)1.96580135
134Urinary bladder sphincter dysfunction (HP:0002839)1.96047075
135Abnormal rod and cone electroretinograms (HP:0008323)1.95309974
136Genital tract atresia (HP:0001827)1.94386703
137Stenosis of the external auditory canal (HP:0000402)1.93748548
138Abnormality of the renal cortex (HP:0011035)1.92857933
139Agitation (HP:0000713)1.91924329
140Vaginal atresia (HP:0000148)1.91684080
141Chronic hepatic failure (HP:0100626)1.91620097
142Aplasia/Hypoplasia of the hallux (HP:0008362)1.91403191
143Short tibia (HP:0005736)1.90157242
144Hypergammaglobulinemia (HP:0010702)1.89172032
145Vertigo (HP:0002321)1.87956923
146Primary atrial arrhythmia (HP:0001692)1.87654305
147Reticulocytopenia (HP:0001896)1.87245735
148Gangrene (HP:0100758)1.87166036
1493-Methylglutaconic aciduria (HP:0003535)1.87150135
150Bony spicule pigmentary retinopathy (HP:0007737)1.87020213
151Epileptic encephalopathy (HP:0200134)1.86872439
152Dynein arm defect of respiratory motile cilia (HP:0012255)1.86356473
153Absent/shortened dynein arms (HP:0200106)1.86356473
154Aplasia/hypoplasia of the uterus (HP:0008684)1.85097715
155Neoplasm of the lung (HP:0100526)1.84846396
156Hypoplasia of the ulna (HP:0003022)1.84754177
157Cortical visual impairment (HP:0100704)1.84370215
158Hypoglycemic seizures (HP:0002173)1.84309038
159Absent rod-and cone-mediated responses on ERG (HP:0007688)1.84130873
160Eczematoid dermatitis (HP:0000976)1.83442838
161Optic nerve hypoplasia (HP:0000609)1.83095052
162Palpebral edema (HP:0100540)1.81293622
163Abnormality of the lower motor neuron (HP:0002366)1.81142318
164Recurrent cutaneous fungal infections (HP:0011370)1.80543063
165Chronic mucocutaneous candidiasis (HP:0002728)1.80543063
166Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.80070289
167Vertebral compression fractures (HP:0002953)1.79903410
168Bulbous nose (HP:0000414)1.79718378
169Asymmetry of the thorax (HP:0001555)1.78824386
170Periorbital edema (HP:0100539)1.76797613
171Abnormality of the fovea (HP:0000493)1.76730113
172Abnormality of the thoracic spine (HP:0100711)1.76018768
173Amyotrophic lateral sclerosis (HP:0007354)1.74437765
174Abnormality of the endocardium (HP:0004306)1.74025943
175Supraventricular arrhythmia (HP:0005115)1.73561780
176Symphalangism affecting the phalanges of the hand (HP:0009773)1.73498919
177Hyperventilation (HP:0002883)1.73115408
178Urticaria (HP:0001025)1.72562727
1792-3 toe syndactyly (HP:0004691)1.72395217
180Poor coordination (HP:0002370)1.71843417
181Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.71026814
182Protruding tongue (HP:0010808)1.70663720
183Duplicated collecting system (HP:0000081)1.70353400
184Abnormality of the labia minora (HP:0012880)1.69846688
185Short 4th metacarpal (HP:0010044)1.69828004
186Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.69828004
187Abnormal respiratory epithelium morphology (HP:0012253)1.68999812
188Abnormal respiratory motile cilium morphology (HP:0005938)1.68999812
189Mesangial abnormality (HP:0001966)1.68780564
190Aplasia/Hypoplasia of the patella (HP:0006498)1.68778739
191Tubular atrophy (HP:0000092)1.68543530
192Persistence of primary teeth (HP:0006335)1.67397650

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR7.13543353
2SIK34.99570405
3TIE14.68500444
4PNCK4.47621042
5WNK44.02126689
6TGFBR23.63919009
7STK392.93359835
8FRK2.91900005
9TNIK2.71303239
10MAP3K142.36718946
11SIK22.35972552
12SIK12.26591406
13CDK82.23693435
14PINK12.20133276
15CDK192.20052604
16MAP3K42.18016634
17CASK2.15648269
18JAK32.08254693
19TGFBR12.04602426
20TLK11.99843224
21CAMK1G1.91091110
22RPS6KA21.86900563
23BMPR21.78571861
24BLK1.72177448
25ZAK1.68198791
26GRK11.64900103
27MAP3K91.52511965
28TAF11.52433192
29JAK11.48339236
30BMPR1B1.42021159
31MARK31.41987287
32ADRBK21.38210183
33PIM21.35362799
34TAOK31.35007661
35IKBKB1.33139683
36YES11.29544147
37TXK1.24360699
38IRAK31.23633260
39PLK41.22824788
40INSRR1.20714446
41NTRK21.17980801
42MARK11.17500743
43PRKCG1.16090391
44MKNK21.14273516
45OXSR11.13465536
46DYRK21.13289915
47SGK11.12585311
48WNK31.11949973
49TYRO31.11853819
50MAP2K41.08496055
51NUAK11.07363971
52TYK21.01311573
53SGK21.00796113
54TEC1.00710420
55EPHA30.96113862
56STK110.95338640
57CDC70.94793943
58TBK10.92537847
59PRKD30.91455161
60STK38L0.90511269
61JAK20.89906588
62CAMK40.88807638
63MUSK0.87965461
64IKBKE0.86794644
65CHUK0.79934235
66CLK10.79729529
67TRPM70.78541076
68ADRBK10.77676534
69PAK30.75973985
70MAPKAPK50.73429235
71STK160.72442510
72IRAK40.71162844
73PRKACA0.69066035
74CAMK10.68857979
75DYRK30.68397074
76MKNK10.68055807
77PRPF4B0.66240749
78DYRK1A0.64599559
79GRK50.62319038
80LYN0.61502551
81ERBB30.61419091
82PHKG20.61286956
83PHKG10.61286956
84AKT30.61146328
85NTRK30.60150724
86CDK30.59551208
87PIK3CA0.58334503
88EPHB20.57487146
89PIM10.57456470
90ACVR1B0.57336217
91NEK90.57101351
92TNK20.56986116
93SGK30.56137832
94PLK10.55043526
95CAMK1D0.54459461
96GRK70.53889457
97CDK90.53292180
98PDGFRB0.52493280
99TAOK20.52491835
100CSNK1G20.52063724
101NEK20.50499492
102PTK2B0.50152212
103MAPKAPK30.49839093
104PRKCE0.49482191
105SGK4940.49024204
106SGK2230.49024204
107PRKCQ0.48922170
108RPS6KA10.48782458
109WNK10.48646083
110AURKA0.48449104
111MINK10.48309875
112CDK50.47978005
113ABL20.47947623
114CAMKK20.47619952
115MAPK130.46741130
116PRKCZ0.46149069
117HCK0.45401309
118RPS6KA30.44497710
119LATS10.44212590
120BTK0.43405623
121MET0.43323730
122KIT0.43259777
123CAMK2A0.42820149
124EIF2AK20.42628420
125RIPK40.42617189
126PRKACG0.42251042
127MAPK120.42194780
128EPHA40.40519096
129CSF1R0.40132870
130PTK60.39371004
131PRKD20.38667831
132RPS6KB10.37092171
133MAPK150.36831921
134MAPK70.36792412
135MAP2K70.36394516
136MAP2K20.36186928
137CSNK1E0.34797054
138ERBB20.34598370
139SYK0.34021594
140STK240.33597866
141IGF1R0.33403025
142BCR0.33286625
143CSNK1A10.33254977
144PRKCH0.32996056
145MAP2K60.32655983
146STK30.31386275
147PRKCD0.30703701
148RAF10.30694999
149STK380.30660120
150RPS6KA60.30649545
151VRK10.30419060
152MAP3K120.30046117
153RPS6KA40.28981724
154RPS6KC10.28620779
155RPS6KL10.28620779
156CSK0.28082381
157BRAF0.28071135
158IRAK10.28070968
159MARK20.27584414
160PLK20.25986600
161MAPK40.25652832

Predicted pathways (KEGG)

RankGene SetZ-score
1Malaria_Homo sapiens_hsa051443.14255191
2Phototransduction_Homo sapiens_hsa047442.80539144
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.78073461
4African trypanosomiasis_Homo sapiens_hsa051432.70135216
5Oxidative phosphorylation_Homo sapiens_hsa001902.52549330
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.32286136
7Cardiac muscle contraction_Homo sapiens_hsa042602.31075796
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.22211121
9Homologous recombination_Homo sapiens_hsa034402.20725101
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.17616033
11TNF signaling pathway_Homo sapiens_hsa046682.15919531
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.14346645
13Linoleic acid metabolism_Homo sapiens_hsa005912.12547027
14Allograft rejection_Homo sapiens_hsa053302.09238305
15Parkinsons disease_Homo sapiens_hsa050122.06881586
16Ribosome_Homo sapiens_hsa030102.06312644
17Leishmaniasis_Homo sapiens_hsa051402.01606318
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.99289641
19Measles_Homo sapiens_hsa051621.97924483
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.94520559
21Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.90124731
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.81924650
23Rheumatoid arthritis_Homo sapiens_hsa053231.78465889
24Graft-versus-host disease_Homo sapiens_hsa053321.76825825
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.75401761
26Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.74915546
27Autoimmune thyroid disease_Homo sapiens_hsa053201.71857336
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.67847048
29Selenocompound metabolism_Homo sapiens_hsa004501.62515451
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.61428762
31Huntingtons disease_Homo sapiens_hsa050161.60933471
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.60301515
33Alzheimers disease_Homo sapiens_hsa050101.58962795
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.56450729
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.53802588
36Fanconi anemia pathway_Homo sapiens_hsa034601.52986563
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.50404702
38Sulfur relay system_Homo sapiens_hsa041221.50326187
39Dopaminergic synapse_Homo sapiens_hsa047281.47519111
40Osteoclast differentiation_Homo sapiens_hsa043801.38675748
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.38478081
42Dorso-ventral axis formation_Homo sapiens_hsa043201.37024339
43Basal transcription factors_Homo sapiens_hsa030221.36474655
44Nicotine addiction_Homo sapiens_hsa050331.36191444
45Herpes simplex infection_Homo sapiens_hsa051681.35889414
46Insulin secretion_Homo sapiens_hsa049111.34772992
47Influenza A_Homo sapiens_hsa051641.34527811
48NOD-like receptor signaling pathway_Homo sapiens_hsa046211.33519114
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.32103719
50Retinol metabolism_Homo sapiens_hsa008301.29286363
51RNA degradation_Homo sapiens_hsa030181.25284953
52Regulation of autophagy_Homo sapiens_hsa041401.21266285
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21105453
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.21016224
55Tuberculosis_Homo sapiens_hsa051521.20069983
56Oxytocin signaling pathway_Homo sapiens_hsa049211.18788900
57Toxoplasmosis_Homo sapiens_hsa051451.18578154
58Ether lipid metabolism_Homo sapiens_hsa005651.18371309
59RNA polymerase_Homo sapiens_hsa030201.15266817
60Maturity onset diabetes of the young_Homo sapiens_hsa049501.15145951
61Staphylococcus aureus infection_Homo sapiens_hsa051501.14951496
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13717880
63Ovarian steroidogenesis_Homo sapiens_hsa049131.13395566
64Gastric acid secretion_Homo sapiens_hsa049711.11216108
65Cocaine addiction_Homo sapiens_hsa050301.10954107
66Type I diabetes mellitus_Homo sapiens_hsa049401.09205266
67Pertussis_Homo sapiens_hsa051331.06479818
68Protein export_Homo sapiens_hsa030601.06014795
69Chemokine signaling pathway_Homo sapiens_hsa040621.03947091
70Hedgehog signaling pathway_Homo sapiens_hsa043401.02270002
71Tryptophan metabolism_Homo sapiens_hsa003801.00930611
72Primary immunodeficiency_Homo sapiens_hsa053401.00244668
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.99111936
74Hematopoietic cell lineage_Homo sapiens_hsa046400.98968220
75Chemical carcinogenesis_Homo sapiens_hsa052040.98751828
76Nucleotide excision repair_Homo sapiens_hsa034200.98528585
77Morphine addiction_Homo sapiens_hsa050320.97647665
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96775192
79Basal cell carcinoma_Homo sapiens_hsa052170.95799246
80Type II diabetes mellitus_Homo sapiens_hsa049300.94565318
81Hepatitis B_Homo sapiens_hsa051610.94020051
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.92954533
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91944400
84Legionellosis_Homo sapiens_hsa051340.91687482
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91600555
86Apoptosis_Homo sapiens_hsa042100.90925131
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.87766030
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87355623
89Hepatitis C_Homo sapiens_hsa051600.86939834
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.86777809
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.86679291
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84907050
93Taste transduction_Homo sapiens_hsa047420.84882779
94Salmonella infection_Homo sapiens_hsa051320.83755924
95Olfactory transduction_Homo sapiens_hsa047400.83663964
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83649769
97* MAPK signaling pathway_Homo sapiens_hsa040100.81937499
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.80863035
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79029505
100Long-term depression_Homo sapiens_hsa047300.78706017
101Serotonergic synapse_Homo sapiens_hsa047260.77355616
102Nitrogen metabolism_Homo sapiens_hsa009100.77185566
103ABC transporters_Homo sapiens_hsa020100.76016259
104Amphetamine addiction_Homo sapiens_hsa050310.75253956
105Dilated cardiomyopathy_Homo sapiens_hsa054140.75003456
106Arachidonic acid metabolism_Homo sapiens_hsa005900.74602038
107Complement and coagulation cascades_Homo sapiens_hsa046100.73487913
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.73381513
109Calcium signaling pathway_Homo sapiens_hsa040200.68558233
110Phagosome_Homo sapiens_hsa041450.68390342
111Mineral absorption_Homo sapiens_hsa049780.67283777
112Viral myocarditis_Homo sapiens_hsa054160.65341428
113Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65250907
114Asthma_Homo sapiens_hsa053100.64486780
115* Melanoma_Homo sapiens_hsa052180.63304817
116* Ras signaling pathway_Homo sapiens_hsa040140.60400534
117Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.60063214
118Small cell lung cancer_Homo sapiens_hsa052220.59596253
119Notch signaling pathway_Homo sapiens_hsa043300.59580299
120Axon guidance_Homo sapiens_hsa043600.59376632
121Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59080883
122Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58498131
123Wnt signaling pathway_Homo sapiens_hsa043100.57707453
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57359813
125Sphingolipid metabolism_Homo sapiens_hsa006000.56919007
126Primary bile acid biosynthesis_Homo sapiens_hsa001200.56738098
127Platelet activation_Homo sapiens_hsa046110.55717450
128Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55657762
129beta-Alanine metabolism_Homo sapiens_hsa004100.55242911
130Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54672162
131Prolactin signaling pathway_Homo sapiens_hsa049170.54206097
132Long-term potentiation_Homo sapiens_hsa047200.53106568
133Glycerolipid metabolism_Homo sapiens_hsa005610.52642520
134Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52540729
135Pancreatic cancer_Homo sapiens_hsa052120.52389175
136Glutamatergic synapse_Homo sapiens_hsa047240.52057242
137Mismatch repair_Homo sapiens_hsa034300.51477676
138Fatty acid degradation_Homo sapiens_hsa000710.50724114
139* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50446807
140HTLV-I infection_Homo sapiens_hsa051660.49963682
141* Rap1 signaling pathway_Homo sapiens_hsa040150.49915033
142Circadian entrainment_Homo sapiens_hsa047130.49667922
143Vitamin digestion and absorption_Homo sapiens_hsa049770.49530138
144Cholinergic synapse_Homo sapiens_hsa047250.48490768
145Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.47261694
146ECM-receptor interaction_Homo sapiens_hsa045120.47218239
147ErbB signaling pathway_Homo sapiens_hsa040120.46364465
148Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45590277
149Base excision repair_Homo sapiens_hsa034100.45034905
150Hippo signaling pathway_Homo sapiens_hsa043900.44290490
151Caffeine metabolism_Homo sapiens_hsa002320.43565131
152Peroxisome_Homo sapiens_hsa041460.42961412
153Focal adhesion_Homo sapiens_hsa045100.42602970
154HIF-1 signaling pathway_Homo sapiens_hsa040660.41490799
155Propanoate metabolism_Homo sapiens_hsa006400.41269916
156GABAergic synapse_Homo sapiens_hsa047270.41265005
157Renin secretion_Homo sapiens_hsa049240.40354919
158cAMP signaling pathway_Homo sapiens_hsa040240.39704375
159Butanoate metabolism_Homo sapiens_hsa006500.39676523
160Amoebiasis_Homo sapiens_hsa051460.39623697
161Acute myeloid leukemia_Homo sapiens_hsa052210.38681487
162Synaptic vesicle cycle_Homo sapiens_hsa047210.37869872
163Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37521705
164Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36226886
165Vascular smooth muscle contraction_Homo sapiens_hsa042700.36186416
166Histidine metabolism_Homo sapiens_hsa003400.34033771
167Tyrosine metabolism_Homo sapiens_hsa003500.33393801
168Fat digestion and absorption_Homo sapiens_hsa049750.32206545
169Metabolic pathways_Homo sapiens_hsa011000.31510627

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