FGF4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1primitive streak formation (GO:0090009)7.35442832
2nodal signaling pathway (GO:0038092)7.01427839
3negative regulation of androgen receptor signaling pathway (GO:0060766)5.96503412
4regulation of posttranscriptional gene silencing (GO:0060147)5.90512707
5regulation of gene silencing by miRNA (GO:0060964)5.90512707
6regulation of gene silencing by RNA (GO:0060966)5.90512707
7protein complex localization (GO:0031503)5.48320470
8cell fate commitment involved in formation of primary germ layer (GO:0060795)5.47064472
9notochord development (GO:0030903)5.37326936
10nuclear pore organization (GO:0006999)5.24886647
11embryonic process involved in female pregnancy (GO:0060136)5.12142391
12L-serine metabolic process (GO:0006563)5.06176723
13regulation of helicase activity (GO:0051095)4.92662159
14nuclear pore complex assembly (GO:0051292)4.92400517
15ribosomal small subunit assembly (GO:0000028)4.91950097
16DNA replication-dependent nucleosome organization (GO:0034723)4.90995895
17DNA replication-dependent nucleosome assembly (GO:0006335)4.90995895
18regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901214.81464917
19regulation of gene expression by genetic imprinting (GO:0006349)4.75691066
20maternal placenta development (GO:0001893)4.60400952
21DNA replication initiation (GO:0006270)4.56709627
22somatic hypermutation of immunoglobulin genes (GO:0016446)4.55349254
23somatic diversification of immune receptors via somatic mutation (GO:0002566)4.55349254
24mitotic metaphase plate congression (GO:0007080)4.51346244
25protein localization to kinetochore (GO:0034501)4.50701361
26cell migration involved in gastrulation (GO:0042074)4.46790001
27nucleobase biosynthetic process (GO:0046112)4.45824692
28folic acid-containing compound biosynthetic process (GO:0009396)4.41120147
29serine family amino acid biosynthetic process (GO:0009070)4.38032083
30determination of adult lifespan (GO:0008340)4.34902351
31IMP biosynthetic process (GO:0006188)4.29374792
32DNA unwinding involved in DNA replication (GO:0006268)4.25157397
33blastocyst development (GO:0001824)4.24858257
34regulation of DNA methylation (GO:0044030)4.21795366
35pentose metabolic process (GO:0019321)4.19644859
36purine nucleobase biosynthetic process (GO:0009113)4.18893537
37regulation of histone H3-K9 methylation (GO:0051570)4.18638716
38negative regulation of microtubule polymerization (GO:0031115)4.16563636
39regulation of activin receptor signaling pathway (GO:0032925)4.15136913
40cellular response to zinc ion (GO:0071294)4.13520560
41mitotic nuclear envelope disassembly (GO:0007077)4.11461340
42response to dietary excess (GO:0002021)4.09932848
43morphogenesis of an epithelial fold (GO:0060571)4.09200844
44negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.06267716
45lung-associated mesenchyme development (GO:0060484)4.03542161
46negative regulation of epidermal cell differentiation (GO:0045605)3.99829813
47negative regulation of histone methylation (GO:0031061)3.97842742
48formation of translation preinitiation complex (GO:0001731)3.97681200
49protein K6-linked ubiquitination (GO:0085020)3.97281666
50cellular response to cadmium ion (GO:0071276)3.96112325
51anterior/posterior axis specification, embryo (GO:0008595)3.94419540
52regulation of mesoderm development (GO:2000380)3.92043661
53cellular protein complex localization (GO:0034629)3.89965975
54ribosome biogenesis (GO:0042254)3.86778826
55ribosome assembly (GO:0042255)3.85820981
56metaphase plate congression (GO:0051310)3.85540437
57heterochromatin organization (GO:0070828)3.85201233
58DNA replication checkpoint (GO:0000076)3.83867189
59mitotic sister chromatid segregation (GO:0000070)3.83830749
60membrane disassembly (GO:0030397)3.83786950
61nuclear envelope disassembly (GO:0051081)3.83786950
62DNA strand elongation involved in DNA replication (GO:0006271)3.82166847
63protein localization to chromosome, centromeric region (GO:0071459)3.81437144
64histone H4-K12 acetylation (GO:0043983)3.79733458
65negative regulation of epidermis development (GO:0045683)3.79168865
66regulation of stem cell maintenance (GO:2000036)3.75859322
67regulation of timing of cell differentiation (GO:0048505)3.75310317
68maturation of SSU-rRNA (GO:0030490)3.74824879
69regulation of cell fate commitment (GO:0010453)3.74762312
70SMAD protein signal transduction (GO:0060395)3.73941087
71pre-miRNA processing (GO:0031054)3.71989846
72regulation of nuclear cell cycle DNA replication (GO:0033262)3.71744173
73pore complex assembly (GO:0046931)3.71254955
74regulation of gene silencing (GO:0060968)3.70891235
75regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.69298912
76IMP metabolic process (GO:0046040)3.67675863
77DNA geometric change (GO:0032392)3.66160313
78regulation of development, heterochronic (GO:0040034)3.65979147
79DNA duplex unwinding (GO:0032508)3.65182027
80positive regulation of catenin import into nucleus (GO:0035413)3.63767401
81DNA strand elongation (GO:0022616)3.62054558
82paraxial mesoderm development (GO:0048339)3.61173231
83genetic imprinting (GO:0071514)3.60850709
84histone arginine methylation (GO:0034969)3.57977596
85regulation of telomere maintenance via telomerase (GO:0032210)3.57220159
86ncRNA 3-end processing (GO:0043628)3.53959542
87positive regulation of SMAD protein import into nucleus (GO:0060391)3.53750373
88regulation of translational fidelity (GO:0006450)3.52939583
89regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.46176216
90positive regulation of chromosome segregation (GO:0051984)3.45233932
91regulation of spindle organization (GO:0090224)3.45193939
92ribonucleoprotein complex biogenesis (GO:0022613)3.44706942
93morphogenesis of embryonic epithelium (GO:0016331)3.42947621
94regulation of chromatin silencing (GO:0031935)3.42235674
95regulation of mitotic spindle organization (GO:0060236)3.41270321
96sister chromatid segregation (GO:0000819)3.38896479
97chromatin assembly (GO:0031497)3.38056584
98chromatin remodeling at centromere (GO:0031055)3.37309941
99telomere maintenance via semi-conservative replication (GO:0032201)3.34428155
100activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.29603867
101serine family amino acid catabolic process (GO:0009071)3.29479620
102establishment of chromosome localization (GO:0051303)3.27085656
103negative regulation of activin receptor signaling pathway (GO:0032926)3.24467093
104mitochondrial RNA metabolic process (GO:0000959)3.23756406
105negative regulation of gene silencing (GO:0060969)3.23312547
106digestive tract morphogenesis (GO:0048546)3.22267815
107activin receptor signaling pathway (GO:0032924)3.16471776
108collecting duct development (GO:0072044)3.15487499
109maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.15141107
110regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.14519330
111NADPH regeneration (GO:0006740)3.14468580
112myeloid cell homeostasis (GO:0002262)3.13153921
113establishment of apical/basal cell polarity (GO:0035089)3.13005116
114glycine metabolic process (GO:0006544)3.12891694
115histone H2A monoubiquitination (GO:0035518)3.11884033
116regulation of centrosome cycle (GO:0046605)3.10677003
117kinetochore organization (GO:0051383)3.10273901
118negative regulation of cell fate commitment (GO:0010454)3.09674944
119mitotic chromosome condensation (GO:0007076)3.08377731
1204-hydroxyproline metabolic process (GO:0019471)3.08167421
121CENP-A containing nucleosome assembly (GO:0034080)3.08113116
122ribosomal large subunit biogenesis (GO:0042273)3.06051068
123regulation of translational termination (GO:0006449)3.04877570
124proline metabolic process (GO:0006560)3.04775349
125somite rostral/caudal axis specification (GO:0032525)3.04315790
126trophoblast giant cell differentiation (GO:0060707)3.04126834
127peptidyl-arginine omega-N-methylation (GO:0035247)3.04066863
128placenta development (GO:0001890)3.03722445
129establishment of integrated proviral latency (GO:0075713)3.03031756
130rRNA processing (GO:0006364)3.02562732
131DNA replication-independent nucleosome organization (GO:0034724)3.02327091
132DNA replication-independent nucleosome assembly (GO:0006336)3.02327091
133mitochondrial fusion (GO:0008053)3.01313787
134spindle assembly involved in mitosis (GO:0090307)3.01080073
135mismatch repair (GO:0006298)2.99878344
136telomere maintenance via telomere lengthening (GO:0010833)2.99761820
137ribosomal small subunit biogenesis (GO:0042274)2.99394585
138kinetochore assembly (GO:0051382)2.98741289
139chromatin assembly or disassembly (GO:0006333)2.97995832
140lung morphogenesis (GO:0060425)2.97566184
141histone H4-K5 acetylation (GO:0043981)2.96671551
142histone H4-K8 acetylation (GO:0043982)2.96671551
143regulation of androgen receptor signaling pathway (GO:0060765)2.96501226
144pentose-phosphate shunt (GO:0006098)2.96151778
145regulation of G0 to G1 transition (GO:0070316)2.94719070
146intra-S DNA damage checkpoint (GO:0031573)2.93398650
147rRNA metabolic process (GO:0016072)2.93198696
148positive regulation of mitotic sister chromatid separation (GO:1901970)2.93022270
149positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.93022270
150positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.93022270
151telomere maintenance via recombination (GO:0000722)2.92649662
152folic acid metabolic process (GO:0046655)2.91478660
153regulation of chromosome segregation (GO:0051983)2.91446148
154mitotic recombination (GO:0006312)2.90695927
155single strand break repair (GO:0000012)2.90045886
156attachment of spindle microtubules to kinetochore (GO:0008608)2.89647235
157histone exchange (GO:0043486)2.88876156
158nuclear envelope organization (GO:0006998)2.88653996
159negative regulation of chromosome segregation (GO:0051985)2.86685608
160chaperone-mediated protein complex assembly (GO:0051131)2.86335633
161cell surface receptor signaling pathway involved in heart development (GO:0061311)2.85254296
162regulation of SMAD protein import into nucleus (GO:0060390)2.84619805
163regulation of sister chromatid cohesion (GO:0007063)2.84211369
164peptidyl-arginine N-methylation (GO:0035246)2.84025023
165peptidyl-arginine methylation (GO:0018216)2.84025023
166replication fork processing (GO:0031297)2.83263917
167female gonad development (GO:0008585)2.80514818
168serine family amino acid metabolic process (GO:0009069)2.79713399
169DNA topological change (GO:0006265)2.77652051
170positive regulation of interleukin-1 beta secretion (GO:0050718)2.76657483
171rRNA transcription (GO:0009303)2.72673570
172regulation of cell fate specification (GO:0042659)2.70142887
173L-alpha-amino acid transmembrane transport (GO:1902475)2.68994528

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.48162949
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.30397864
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.87449608
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.83086323
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.63526730
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.63526730
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.63526730
8SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.35380812
9MYC_19079543_ChIP-ChIP_MESCs_Mouse3.27663640
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.20910539
11POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.15997071
12* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.70006053
13NANOG_18555785_ChIP-Seq_MESCs_Mouse2.67592999
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.67364445
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.59105693
16NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.55441332
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.43396432
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.39205797
19* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.34670599
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.32553927
21SALL1_21062744_ChIP-ChIP_HESCs_Human2.25694033
22MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.24363792
23STAT3_1855785_ChIP-Seq_MESCs_Mouse2.23307540
24POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.21034459
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.20365141
26* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.19295869
27* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15508975
28SOX2_18555785_ChIP-Seq_MESCs_Mouse2.15340011
29* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.13220056
30* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.12632189
31* POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.09572862
32* SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.07864836
33ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.98481677
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.90774803
35EST1_17652178_ChIP-ChIP_JURKAT_Human1.86000845
36ETS1_20019798_ChIP-Seq_JURKAT_Human1.83293077
37ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.81714285
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.81586786
39XRN2_22483619_ChIP-Seq_HELA_Human1.79802332
40* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.79752750
41* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.78851370
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.75678942
43* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.74881984
44KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.74452907
45ESR1_15608294_ChIP-ChIP_MCF-7_Human1.70842990
46JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.70593322
47CREB1_15753290_ChIP-ChIP_HEK293T_Human1.69390567
48KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.67956840
49ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.67741547
50HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.63894830
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.62691540
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.61094182
53* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.59958982
54AR_21909140_ChIP-Seq_LNCAP_Human1.57845112
55NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.54398098
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.54326668
57* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.52931073
58* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.48977462
59* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.44538131
60KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.44222932
61FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.42869126
62GABP_17652178_ChIP-ChIP_JURKAT_Human1.42747123
63* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.40593884
64VDR_23849224_ChIP-Seq_CD4+_Human1.39029941
65GATA1_26923725_Chip-Seq_HPCs_Mouse1.37157942
66NANOG_21062744_ChIP-ChIP_HESCs_Human1.36774383
67* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.35957055
68THAP11_20581084_ChIP-Seq_MESCs_Mouse1.35267405
69* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.34979678
70* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.33170163
71YY1_21170310_ChIP-Seq_MESCs_Mouse1.32818102
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32395680
73TTF2_22483619_ChIP-Seq_HELA_Human1.29839713
74TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27618470
75* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.24477574
76YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24278524
77FOXP3_21729870_ChIP-Seq_TREG_Human1.23638268
78DCP1A_22483619_ChIP-Seq_HELA_Human1.18672243
79ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17278744
80KAP1_27257070_Chip-Seq_ESCs_Mouse1.16064742
81TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.15499871
82SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.14249988
83KDM5A_27292631_Chip-Seq_BREAST_Human1.14230228
84GABP_19822575_ChIP-Seq_HepG2_Human1.11606327
85ELF1_17652178_ChIP-ChIP_JURKAT_Human1.10586904
86ZNF263_19887448_ChIP-Seq_K562_Human1.08648306
87NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08189552
88MYC_22102868_ChIP-Seq_BL_Human1.07184497
89SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.05910297
90CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05512986
91TET1_21451524_ChIP-Seq_MESCs_Mouse1.05468410
92POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.05112243
93MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05029673
94ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04469139
95* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.04336364
96TP63_19390658_ChIP-ChIP_HaCaT_Human1.03241484
97LXR_22292898_ChIP-Seq_THP-1_Human1.02263039
98NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.02196211
99PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01419101
100HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.97070361
101BCOR_27268052_Chip-Seq_Bcells_Human0.97014515
102CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96139168
103CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96044158
104TFEB_21752829_ChIP-Seq_HELA_Human0.95643791
105* NANOG_16518401_ChIP-PET_MESCs_Mouse0.94857743
106ELK1_19687146_ChIP-ChIP_HELA_Human0.93754023
107PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.93624896
108CIITA_25753668_ChIP-Seq_RAJI_Human0.93215865
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91895005
110TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91481933
111SA1_27219007_Chip-Seq_ERYTHROID_Human0.89603047
112CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.89518465
113RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.88985858
114NANOG_16153702_ChIP-ChIP_HESCs_Human0.87156631
115SOX2_16153702_ChIP-ChIP_HESCs_Human0.85942964
116CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.85415714
117DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85188999
118HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.83979549
119SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.79439512

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004957_abnormal_blastocyst_morpholog4.43456446
2MP0003693_abnormal_embryo_hatching4.38392851
3MP0008057_abnormal_DNA_replication4.38195515
4MP0003111_abnormal_nucleus_morphology4.31618149
5MP0010094_abnormal_chromosome_stability4.30382292
6MP0002254_reproductive_system_inflammat3.66150287
7MP0003077_abnormal_cell_cycle3.62827517
8MP0003806_abnormal_nucleotide_metabolis3.62600757
9MP0008058_abnormal_DNA_repair2.96646250
10MP0005257_abnormal_intraocular_pressure2.93026815
11MP0002653_abnormal_ependyma_morphology2.89227564
12MP0004133_heterotaxia2.79157264
13MP0010352_gastrointestinal_tract_polyps2.69872608
14MP0001730_embryonic_growth_arrest2.52517980
15MP0000350_abnormal_cell_proliferation2.46488860
16MP0003123_paternal_imprinting2.39745587
17MP0000566_synostosis2.36985451
18MP0008932_abnormal_embryonic_tissue2.32313172
19MP0003136_yellow_coat_color2.31632267
20MP0010307_abnormal_tumor_latency2.27429104
21MP0003283_abnormal_digestive_organ2.24803559
22MP0001672_abnormal_embryogenesis/_devel2.11754400
23MP0005380_embryogenesis_phenotype2.11754400
24* MP0002084_abnormal_developmental_patter2.05023719
25* MP0002085_abnormal_embryonic_tissue2.03364233
26MP0008007_abnormal_cellular_replicative2.02472863
27MP0003718_maternal_effect1.92652227
28MP0003941_abnormal_skin_development1.91372850
29MP0001697_abnormal_embryo_size1.90910711
30MP0004197_abnormal_fetal_growth/weight/1.86622463
31MP0003786_premature_aging1.85663453
32* MP0002086_abnormal_extraembryonic_tissu1.82442309
33MP0004858_abnormal_nervous_system1.82007554
34MP0003890_abnormal_embryonic-extraembry1.81230523
35MP0003984_embryonic_growth_retardation1.78220356
36MP0008260_abnormal_autophagy1.77995043
37MP0003119_abnormal_digestive_system1.77300937
38MP0002088_abnormal_embryonic_growth/wei1.75653356
39MP0001293_anophthalmia1.74504868
40MP0002822_catalepsy1.73252617
41MP0002089_abnormal_postnatal_growth/wei1.72826943
42MP0000462_abnormal_digestive_system1.71924194
43MP0000428_abnormal_craniofacial_morphol1.71458529
44MP0005076_abnormal_cell_differentiation1.70407600
45* MP0002080_prenatal_lethality1.65249975
46MP0008877_abnormal_DNA_methylation1.62441736
47MP0006292_abnormal_olfactory_placode1.53041293
48MP0003705_abnormal_hypodermis_morpholog1.51873505
49MP0006035_abnormal_mitochondrial_morpho1.47262449
50MP0008961_abnormal_basal_metabolism1.39484986
51MP0003121_genomic_imprinting1.39012367
52MP0003566_abnormal_cell_adhesion1.37282614
53MP0009780_abnormal_chondrocyte_physiolo1.34557039
54MP0003567_abnormal_fetal_cardiomyocyte1.34220999
55MP0000750_abnormal_muscle_regeneration1.31215916
56MP0002210_abnormal_sex_determination1.27757623
57MP0010234_abnormal_vibrissa_follicle1.25403713
58MP0000470_abnormal_stomach_morphology1.23025572
59MP0004264_abnormal_extraembryonic_tissu1.22939333
60MP0001849_ear_inflammation1.22886547
61MP0000313_abnormal_cell_death1.22319264
62MP0001145_abnormal_male_reproductive1.20431744
63MP0010030_abnormal_orbit_morphology1.18302699
64MP0000490_abnormal_crypts_of1.16452502
65MP0002909_abnormal_adrenal_gland1.15591317
66MP0005266_abnormal_metabolism1.15537088
67MP0001346_abnormal_lacrimal_gland1.13552118
68MP0000516_abnormal_urinary_system1.13352705
69MP0005367_renal/urinary_system_phenotyp1.13352705
70MP0002111_abnormal_tail_morphology1.02796942
71MP0003453_abnormal_keratinocyte_physiol1.02740619
72MP0002019_abnormal_tumor_incidence1.02267436
73MP0001286_abnormal_eye_development0.98351940
74MP0002163_abnormal_gland_morphology0.96980377
75MP0001929_abnormal_gametogenesis0.96967148
76MP0003699_abnormal_female_reproductive0.94427733
77MP0000653_abnormal_sex_gland0.93578066
78MP0009053_abnormal_anal_canal0.93417905
79MP0003315_abnormal_perineum_morphology0.91495382
80MP0003935_abnormal_craniofacial_develop0.90363910
81MP0003861_abnormal_nervous_system0.90223511
82MP0000537_abnormal_urethra_morphology0.90160424
83MP0003937_abnormal_limbs/digits/tail_de0.90060993
84MP0009703_decreased_birth_body0.89335787
85MP0010630_abnormal_cardiac_muscle0.88744004
86MP0002697_abnormal_eye_size0.87318482
87MP0005501_abnormal_skin_physiology0.87294827
88MP0009278_abnormal_bone_marrow0.84721906
89MP0005023_abnormal_wound_healing0.84709581
90MP0005379_endocrine/exocrine_gland_phen0.84167454
91MP0009333_abnormal_splenocyte_physiolog0.82967866
92MP0003936_abnormal_reproductive_system0.81182148
93MP0002092_abnormal_eye_morphology0.80691516
94MP0005451_abnormal_body_composition0.78984354
95MP0002249_abnormal_larynx_morphology0.78619814
96MP0005384_cellular_phenotype0.78593597
97MP0002796_impaired_skin_barrier0.78389787
98MP0000432_abnormal_head_morphology0.77738166
99MP0002877_abnormal_melanocyte_morpholog0.77468547
100MP0005621_abnormal_cell_physiology0.77001116
101MP0005623_abnormal_meninges_morphology0.76328748
102MP0000371_diluted_coat_color0.76328160
103MP0000358_abnormal_cell_content/0.75947396
104MP0000049_abnormal_middle_ear0.73589029
105MP0003787_abnormal_imprinting0.73420160
106MP0002160_abnormal_reproductive_system0.72371418
107MP0002396_abnormal_hematopoietic_system0.72179422
108MP0001661_extended_life_span0.70900429
109MP0009672_abnormal_birth_weight0.68896689
110MP0000467_abnormal_esophagus_morphology0.68511380
111MP0003950_abnormal_plasma_membrane0.68151281
112MP0004885_abnormal_endolymph0.67893783
113MP0009379_abnormal_foot_pigmentation0.66581422
114MP0004272_abnormal_basement_membrane0.66418748
115MP0005395_other_phenotype0.66179546
116MP0003755_abnormal_palate_morphology0.66078046
117MP0008770_decreased_survivor_rate0.65451392
118MP0004185_abnormal_adipocyte_glucose0.65287258
119MP0001915_intracranial_hemorrhage0.65145022
120MP0006072_abnormal_retinal_apoptosis0.64706211
121MP0003183_abnormal_peptide_metabolism0.64697061
122MP0003385_abnormal_body_wall0.64678613
123MP0002277_abnormal_respiratory_mucosa0.64542891
124MP0002127_abnormal_cardiovascular_syste0.63457473
125MP0003698_abnormal_male_reproductive0.63382384
126MP0008874_decreased_physiological_sensi0.62763279
127MP0002925_abnormal_cardiovascular_devel0.62238632
128MP0003186_abnormal_redox_activity0.62151853
129MP0000477_abnormal_intestine_morphology0.62035440
130MP0002161_abnormal_fertility/fecundity0.60952121
131MP0005389_reproductive_system_phenotype0.60436345
132MP0005197_abnormal_uvea_morphology0.60260221
133MP0002751_abnormal_autonomic_nervous0.60116025
134MP0002269_muscular_atrophy0.59978307
135MP0004233_abnormal_muscle_weight0.59578398
136MP0002090_abnormal_vision0.58849783

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)5.97483971
2Bilateral microphthalmos (HP:0007633)5.58173060
3Abnormality of the labia minora (HP:0012880)4.75438719
4Hyperglycinuria (HP:0003108)4.37272241
5Abnormality of the astrocytes (HP:0100707)4.27113104
6Astrocytoma (HP:0009592)4.27113104
7Breast hypoplasia (HP:0003187)4.24077501
8Birth length less than 3rd percentile (HP:0003561)4.23366344
9Medulloblastoma (HP:0002885)4.07905436
10Chromosomal breakage induced by crosslinking agents (HP:0003221)4.03434940
11Agnosia (HP:0010524)3.96692292
12Chromsome breakage (HP:0040012)3.92616542
13Neoplasm of the oral cavity (HP:0100649)3.92325511
14Supernumerary spleens (HP:0009799)3.85603587
15Absent radius (HP:0003974)3.85154622
16Aplasia/Hypoplasia of the fovea (HP:0008060)3.64729757
17Hypoplasia of the fovea (HP:0007750)3.64729757
18Rhabdomyosarcoma (HP:0002859)3.61770390
19Absent forearm bone (HP:0003953)3.61747991
20Aplasia involving forearm bones (HP:0009822)3.61747991
21Transposition of the great arteries (HP:0001669)3.56356189
22Abnormal connection of the cardiac segments (HP:0011545)3.56356189
23Abnormal ventriculo-arterial connection (HP:0011563)3.56356189
24Glioma (HP:0009733)3.54034165
25Rib fusion (HP:0000902)3.37370243
26Aplasia/hypoplasia of the humerus (HP:0006507)3.34029848
27Hyperglycinemia (HP:0002154)3.32621163
28Selective tooth agenesis (HP:0001592)3.32107816
29Colon cancer (HP:0003003)3.29208576
30Impulsivity (HP:0100710)3.28123568
31Abnormality of serine family amino acid metabolism (HP:0010894)3.24411956
32Abnormality of glycine metabolism (HP:0010895)3.24411956
33Short humerus (HP:0005792)3.15376847
34Missing ribs (HP:0000921)3.10954031
35Carpal bone hypoplasia (HP:0001498)3.07235847
36Aplasia/Hypoplasia of the macula (HP:0008059)3.01314703
37Neoplasm of striated muscle (HP:0009728)3.00150992
38Esophageal atresia (HP:0002032)2.99359091
39Abnormality of the salivary glands (HP:0010286)2.94897754
40Patellar aplasia (HP:0006443)2.93204196
41Split foot (HP:0001839)2.92613456
42Reticulocytopenia (HP:0001896)2.92369456
43Shawl scrotum (HP:0000049)2.90364983
44Progressive muscle weakness (HP:0003323)2.87131759
45Myopathic facies (HP:0002058)2.86726846
46Multiple enchondromatosis (HP:0005701)2.83933687
47Abnormal number of erythroid precursors (HP:0012131)2.83449238
48Abnormality of the fovea (HP:0000493)2.81737150
49Delayed epiphyseal ossification (HP:0002663)2.80684285
50Abnormality of cells of the erythroid lineage (HP:0012130)2.79698917
51Absent thumb (HP:0009777)2.79639435
52Meckel diverticulum (HP:0002245)2.79472667
53Aplasia/Hypoplasia affecting the retina (HP:0008061)2.76419454
54Abnormality of chromosome stability (HP:0003220)2.75067377
55Biliary tract neoplasm (HP:0100574)2.74212703
56Abdominal situs inversus (HP:0003363)2.73669388
57Abnormality of abdominal situs (HP:0011620)2.73669388
58Aplasia/Hypoplasia of the uvula (HP:0010293)2.73179359
59Amelogenesis imperfecta (HP:0000705)2.72316645
60Abnormality of the ileum (HP:0001549)2.72211762
61Rectovaginal fistula (HP:0000143)2.70848465
62Rectal fistula (HP:0100590)2.70848465
63Aplasia/Hypoplasia of the patella (HP:0006498)2.68104630
64Oral leukoplakia (HP:0002745)2.65998006
65Thrombocytosis (HP:0001894)2.65629377
66Choanal stenosis (HP:0000452)2.65333003
67Abnormality of the preputium (HP:0100587)2.62662237
68Partial duplication of thumb phalanx (HP:0009944)2.60733447
69Basal cell carcinoma (HP:0002671)2.58950352
70Hepatoblastoma (HP:0002884)2.54557741
71Abnormality of the anterior horn cell (HP:0006802)2.54359796
72Degeneration of anterior horn cells (HP:0002398)2.54359796
73Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.52204708
74Duplication of thumb phalanx (HP:0009942)2.45881726
75Abnormal number of incisors (HP:0011064)2.45285226
76Cerebral hypomyelination (HP:0006808)2.42348670
77Vertebral clefting (HP:0008428)2.41977516
78Partial duplication of the phalanx of hand (HP:0009999)2.37761414
79Persistence of primary teeth (HP:0006335)2.35112067
80Aplasia involving bones of the upper limbs (HP:0009823)2.34216860
81Aplasia of the phalanges of the hand (HP:0009802)2.34216860
82Aplasia involving bones of the extremities (HP:0009825)2.34216860
83Duplicated collecting system (HP:0000081)2.31986407
84Intestinal fistula (HP:0100819)2.31496519
85Gastrointestinal atresia (HP:0002589)2.30567558
86Amaurosis fugax (HP:0100576)2.28487773
87Premature ovarian failure (HP:0008209)2.27425894
88Supernumerary bones of the axial skeleton (HP:0009144)2.25293326
89Aplasia/Hypoplasia of the sacrum (HP:0008517)2.25167578
90Ectopic anus (HP:0004397)2.24808105
91Neoplasm of the pancreas (HP:0002894)2.24773494
92Asplenia (HP:0001746)2.24744566
93Rough bone trabeculation (HP:0100670)2.24134039
94Vaginal fistula (HP:0004320)2.21115517
95Duodenal stenosis (HP:0100867)2.19583588
96Small intestinal stenosis (HP:0012848)2.19583588
97Supernumerary ribs (HP:0005815)2.18093753
98Turricephaly (HP:0000262)2.17736057
99Tracheoesophageal fistula (HP:0002575)2.17239036
100Horseshoe kidney (HP:0000085)2.14681211
101Stenosis of the external auditory canal (HP:0000402)2.14639906
102Adenoma sebaceum (HP:0009720)2.12562829
103Angiofibromas (HP:0010615)2.12562829
104Anal stenosis (HP:0002025)2.11892285
105Breech presentation (HP:0001623)2.11037092
106Delayed puberty (HP:0000823)2.08220089
107Abnormality of pyrimidine metabolism (HP:0004353)2.08193780
108Homocystinuria (HP:0002156)2.08040129
109Abnormality of homocysteine metabolism (HP:0010919)2.08040129
110Abnormality of the lower motor neuron (HP:0002366)2.08009137
111Proximal placement of thumb (HP:0009623)2.05082760
112Abnormality of the duodenum (HP:0002246)2.04367098
113Myelodysplasia (HP:0002863)2.03942878
114Facial hemangioma (HP:0000329)2.03803226
115Sloping forehead (HP:0000340)2.02669093
116Aplasia/Hypoplasia of the spleen (HP:0010451)2.01888922
117Breast aplasia (HP:0100783)2.01257602
118Hemivertebrae (HP:0002937)2.00505422
119Fused cervical vertebrae (HP:0002949)1.99499357
120Cutaneous syndactyly (HP:0012725)1.99298260
121Deviation of the thumb (HP:0009603)1.98994072
122Cafe-au-lait spot (HP:0000957)1.98821069
123Spinal muscular atrophy (HP:0007269)1.97461836
124Death in infancy (HP:0001522)1.96881315
125Vertebral fusion (HP:0002948)1.94888818
126Trismus (HP:0000211)1.94662456
127Abnormality of the middle phalanges of the toes (HP:0010183)1.93961882
128Pseudobulbar signs (HP:0002200)1.92737121
129Spastic diplegia (HP:0001264)1.92643314
130Metaphyseal cupping (HP:0003021)1.91129670
131Aplasia/Hypoplasia of the sternum (HP:0006714)1.90472242
132Short thumb (HP:0009778)1.90022756
133Gastrointestinal carcinoma (HP:0002672)1.89640004
134Malignant gastrointestinal tract tumors (HP:0006749)1.89640004
135External ophthalmoplegia (HP:0000544)1.88279990
136Bone marrow hypocellularity (HP:0005528)1.88211529
137Sex reversal (HP:0012245)1.87797860
138Abnormal sex determination (HP:0012244)1.87797860
139Ectopic kidney (HP:0000086)1.87732300
140Microvesicular hepatic steatosis (HP:0001414)1.86877803
14111 pairs of ribs (HP:0000878)1.86619677
142Abnormality of the renal collecting system (HP:0004742)1.86483447
143Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.85606507
144Restlessness (HP:0000711)1.84678811
145Dysphonia (HP:0001618)1.84275304
146Dysmetric saccades (HP:0000641)1.82598911
147Round ear (HP:0100830)1.81069765
148Abnormality of the lacrimal duct (HP:0011481)1.79975892
149Facial cleft (HP:0002006)1.79118889
150Septo-optic dysplasia (HP:0100842)1.77287281
151Renal agenesis (HP:0000104)1.75772564
152Nasolacrimal duct obstruction (HP:0000579)1.74854445
153Broad distal phalanx of finger (HP:0009836)1.74506081
154Shallow orbits (HP:0000586)1.73606242
155Insulin resistance (HP:0000855)1.72587544
156Broad thumb (HP:0011304)1.70509250
157Abnormality of the clitoris (HP:0000056)1.69879932
158Abnormality of the vocal cords (HP:0008777)1.68547969
159Abnormal umbilical cord blood vessels (HP:0011403)1.68090473
160Single umbilical artery (HP:0001195)1.68090473
161Abnormality of the fetal cardiovascular system (HP:0010948)1.68090473
162Bronchomalacia (HP:0002780)1.67201077
163Cutaneous finger syndactyly (HP:0010554)1.66951448
164Clitoromegaly (HP:0000057)1.65973959
165Coronal craniosynostosis (HP:0004440)1.63835973
166Atresia of the external auditory canal (HP:0000413)1.63595066
167Methylmalonic aciduria (HP:0012120)1.63496605
168Insulin-resistant diabetes mellitus (HP:0000831)1.62039598
169Osteomalacia (HP:0002749)1.60879414
170Visceral angiomatosis (HP:0100761)1.59655990
171Absent toe (HP:0010760)1.58269503
172Abnormality of the nasolacrimal system (HP:0000614)1.56544423
173Lymphangioma (HP:0100764)1.54942317
174Multifactorial inheritance (HP:0001426)1.54526911

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK27.62203815
2SMG14.69696360
3WEE14.33787300
4PHKG14.29745995
5PHKG24.29745995
6EPHA24.14451516
7CDK123.95235140
8CDC73.46930128
9BUB13.38048789
10NEK13.20368806
11TTK3.06639937
12AKT32.67734394
13TLK12.45930808
14NEK22.43191623
15RPS6KB22.33527905
16VRK22.21212253
17SRPK12.20817166
18PNCK2.13299765
19PLK12.11283060
20CDK72.06151711
21TSSK62.02580899
22CHEK21.81260397
23PASK1.70527049
24EIF2AK11.57763289
25NME11.56208727
26ATR1.56064087
27BRD41.55474925
28PLK31.53036277
29ZAK1.46690243
30AURKB1.46339559
31LATS21.43869671
32AURKA1.42060332
33CHEK11.41421044
34ALK1.35697895
35VRK11.33289069
36CDK41.29751354
37MAP3K81.27361006
38DYRK31.27106821
39STK38L1.25419875
40BRSK21.24906058
41PRPF4B1.24260709
42PRKG21.20521372
43SCYL21.19529265
44FLT31.18552272
45CDK191.18467650
46STK41.16609148
47TESK21.13659478
48MAPKAPK31.12720187
49MKNK11.12567731
50ACVR1B1.12473486
51FGFR41.10449801
52CDK21.09483205
53ATM1.08833120
54STK161.07660180
55MKNK21.06632302
56MET1.04883853
57FGFR21.01807306
58ICK1.01404631
59PRKCI1.00706346
60PAK40.96095152
61PDK20.95970968
62EEF2K0.95757715
63EIF2AK30.93981515
64PIM10.92158441
65STK100.89584341
66NME20.89238978
67KDR0.87300810
68MTOR0.84401384
69PDK40.81201645
70PDK30.81201645
71CSNK1D0.78011772
72MAP3K90.77215464
73CSNK2A20.75949953
74CDK10.75370191
75PLK40.74834694
76RPS6KA20.72860998
77CSNK1E0.72774378
78TAF10.71115865
79LATS10.67692770
80TYRO30.66009635
81MELK0.65777402
82CDK60.65592803
83ERBB40.65402027
84DMPK0.61745080
85PAK10.60483857
86DYRK20.60427486
87MAP3K60.60111391
88AKT20.59336704
89OXSR10.59316321
90BRSK10.58449481
91RPS6KC10.58297906
92RPS6KL10.58297906
93PKN20.57384517
94CSNK2A10.54125417
95TAOK20.51446933
96RPS6KA50.50734958
97RIPK10.50585054
98TGFBR10.50216273
99PRKDC0.49813836
100RPS6KA60.44478290
101MAPK140.43352882
102PINK10.42920113
103CSF1R0.41161150
104STK30.39303430
105GSK3B0.38962946
106BCKDK0.38880652
107WNK40.38622257
108BRAF0.38089764
109MAPK10.37106449
110MAP3K140.36434143
111WNK30.35414128
112MATK0.33497468
113YES10.33330305
114MAPK100.33197625
115BMX0.33196657
116MAP3K100.31734444
117DDR20.31587132
118STK380.30859242
119AKT10.30068166
120CAMK1D0.28626363
121MAP2K20.28392512
122DAPK30.27306372
123FGFR10.26161731
124EIF2AK20.26048717
125GRK60.25714464
126MST40.25502062
127RPS6KA40.24554589
128ROCK20.21166771
129PAK20.21082979
130PBK0.20954743
131PAK60.19956893
132RPS6KB10.18591136
133CLK10.18353517
134STK390.17143165
135RPS6KA10.16875040
136CSNK1A10.16095682
137STK240.15405951
138FGR0.14676347
139CHUK0.13973803

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.74188344
2DNA replication_Homo sapiens_hsa030304.44313847
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.34985933
4RNA transport_Homo sapiens_hsa030133.56447401
5One carbon pool by folate_Homo sapiens_hsa006703.47849531
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.18483402
7Spliceosome_Homo sapiens_hsa030403.16406899
8RNA polymerase_Homo sapiens_hsa030203.01219978
9Homologous recombination_Homo sapiens_hsa034402.84546747
10Nucleotide excision repair_Homo sapiens_hsa034202.83490307
11Ribosome_Homo sapiens_hsa030102.77351205
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.70236841
13Base excision repair_Homo sapiens_hsa034102.60098038
14Fanconi anemia pathway_Homo sapiens_hsa034602.56338428
15Cell cycle_Homo sapiens_hsa041102.56105538
16mRNA surveillance pathway_Homo sapiens_hsa030152.10651135
17Non-homologous end-joining_Homo sapiens_hsa034501.99803085
18Pyrimidine metabolism_Homo sapiens_hsa002401.97648313
19Basal transcription factors_Homo sapiens_hsa030221.89068474
20Proteasome_Homo sapiens_hsa030501.82319060
21RNA degradation_Homo sapiens_hsa030181.75958272
22p53 signaling pathway_Homo sapiens_hsa041151.70173036
23Systemic lupus erythematosus_Homo sapiens_hsa053221.68519183
24Biosynthesis of amino acids_Homo sapiens_hsa012301.49042893
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.35447323
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.34231287
27Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.32876407
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.30860723
29Selenocompound metabolism_Homo sapiens_hsa004501.14277640
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.13800806
31Folate biosynthesis_Homo sapiens_hsa007901.10790270
32Oocyte meiosis_Homo sapiens_hsa041141.10432599
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.09916300
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.07113166
35Vitamin B6 metabolism_Homo sapiens_hsa007501.02379846
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01423453
37Viral carcinogenesis_Homo sapiens_hsa052031.00797382
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00578620
39Purine metabolism_Homo sapiens_hsa002301.00400839
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93937473
41Hippo signaling pathway_Homo sapiens_hsa043900.93764426
42Epstein-Barr virus infection_Homo sapiens_hsa051690.88192705
43Pyruvate metabolism_Homo sapiens_hsa006200.85604407
44Basal cell carcinoma_Homo sapiens_hsa052170.81177113
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80850235
46Mineral absorption_Homo sapiens_hsa049780.80792065
47Fructose and mannose metabolism_Homo sapiens_hsa000510.80011278
48MicroRNAs in cancer_Homo sapiens_hsa052060.79763618
49Carbon metabolism_Homo sapiens_hsa012000.78226201
50Alcoholism_Homo sapiens_hsa050340.75910914
51Drug metabolism - other enzymes_Homo sapiens_hsa009830.74574992
52Pentose phosphate pathway_Homo sapiens_hsa000300.71871614
53TGF-beta signaling pathway_Homo sapiens_hsa043500.71766524
54Glucagon signaling pathway_Homo sapiens_hsa049220.69316658
55Oxidative phosphorylation_Homo sapiens_hsa001900.68140944
56Thyroid cancer_Homo sapiens_hsa052160.66584120
57N-Glycan biosynthesis_Homo sapiens_hsa005100.66314086
58Parkinsons disease_Homo sapiens_hsa050120.64329237
59Notch signaling pathway_Homo sapiens_hsa043300.63235008
60Steroid biosynthesis_Homo sapiens_hsa001000.62230746
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60818514
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59214891
63mTOR signaling pathway_Homo sapiens_hsa041500.58826088
64Insulin signaling pathway_Homo sapiens_hsa049100.56420201
65Starch and sucrose metabolism_Homo sapiens_hsa005000.56193640
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56143080
67Tight junction_Homo sapiens_hsa045300.54416652
68Glutathione metabolism_Homo sapiens_hsa004800.52866114
69Hedgehog signaling pathway_Homo sapiens_hsa043400.52769002
70HTLV-I infection_Homo sapiens_hsa051660.51165501
71Adherens junction_Homo sapiens_hsa045200.49716911
72Vitamin digestion and absorption_Homo sapiens_hsa049770.48834799
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.48625359
74Herpes simplex infection_Homo sapiens_hsa051680.48450517
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47066121
76Bladder cancer_Homo sapiens_hsa052190.45959394
77Arginine and proline metabolism_Homo sapiens_hsa003300.45477448
78Nitrogen metabolism_Homo sapiens_hsa009100.40836930
79Antigen processing and presentation_Homo sapiens_hsa046120.40358299
80Cardiac muscle contraction_Homo sapiens_hsa042600.39875169
81Sulfur relay system_Homo sapiens_hsa041220.39249904
82Lysine degradation_Homo sapiens_hsa003100.39119171
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38259459
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.37358994
85Galactose metabolism_Homo sapiens_hsa000520.36882858
86Colorectal cancer_Homo sapiens_hsa052100.36576058
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35414307
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33605637
89Small cell lung cancer_Homo sapiens_hsa052220.31157787
90Fatty acid elongation_Homo sapiens_hsa000620.27665921
91Melanogenesis_Homo sapiens_hsa049160.27196015
92Wnt signaling pathway_Homo sapiens_hsa043100.25076670
93* Pathways in cancer_Homo sapiens_hsa052000.24883511
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.22967348
95HIF-1 signaling pathway_Homo sapiens_hsa040660.22038281
96Arginine biosynthesis_Homo sapiens_hsa002200.19656745
97Huntingtons disease_Homo sapiens_hsa050160.18893689
98Insulin resistance_Homo sapiens_hsa049310.17329718
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.16786497
100Linoleic acid metabolism_Homo sapiens_hsa005910.16768273
101Fatty acid biosynthesis_Homo sapiens_hsa000610.16443053
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.15890391
103Metabolic pathways_Homo sapiens_hsa011000.15349466
104Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.15339711
105Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.14954207
106Alzheimers disease_Homo sapiens_hsa050100.14543874
107Fat digestion and absorption_Homo sapiens_hsa049750.14108878
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.12559507
109Vibrio cholerae infection_Homo sapiens_hsa051100.11389068
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.11065166
111Apoptosis_Homo sapiens_hsa042100.10973310
112Peroxisome_Homo sapiens_hsa041460.10159286
113Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.09227100
114Protein digestion and absorption_Homo sapiens_hsa049740.08920229
115Arachidonic acid metabolism_Homo sapiens_hsa005900.08084032
116Prostate cancer_Homo sapiens_hsa052150.07908389
117Renin-angiotensin system_Homo sapiens_hsa046140.04897889
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.03696216
119* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.03692802
120Inositol phosphate metabolism_Homo sapiens_hsa005620.02545995
121Prion diseases_Homo sapiens_hsa050200.02428559
122Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.01058200
123AMPK signaling pathway_Homo sapiens_hsa041520.01026008
124Proteoglycans in cancer_Homo sapiens_hsa05205-0.0148927
125Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0089115
126Regulation of autophagy_Homo sapiens_hsa04140-0.0059254
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0058237
128Legionellosis_Homo sapiens_hsa05134-0.0018831
129* Regulation of actin cytoskeleton_Homo sapiens_hsa04810-0.0002129

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