FGF5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)7.28452302
2doxorubicin metabolic process (GO:0044598)7.28452302
3daunorubicin metabolic process (GO:0044597)7.28452302
4cell migration involved in gastrulation (GO:0042074)6.68074423
5regulation of mesoderm development (GO:2000380)6.55921848
6chondrocyte proliferation (GO:0035988)5.58498029
7establishment of integrated proviral latency (GO:0075713)5.33570196
8sequestering of extracellular ligand from receptor (GO:0035581)5.21470480
9protein heterotrimerization (GO:0070208)5.17917827
10endocardial cushion development (GO:0003197)5.17048144
11kidney mesenchyme development (GO:0072074)4.93840206
12collagen fibril organization (GO:0030199)4.89665331
13nodal signaling pathway (GO:0038092)4.86582852
14aminoglycoside antibiotic metabolic process (GO:0030647)4.55423552
15lymphangiogenesis (GO:0001946)4.46610568
16maturation of SSU-rRNA (GO:0030490)4.46106786
17DNA unwinding involved in DNA replication (GO:0006268)4.30140875
18protein complex localization (GO:0031503)4.30108112
19* signal transduction involved in regulation of gene expression (GO:0023019)4.28943467
20negative regulation of nitric-oxide synthase activity (GO:0051001)4.28529308
21cell migration involved in sprouting angiogenesis (GO:0002042)4.21789041
22type B pancreatic cell proliferation (GO:0044342)4.21548193
23negative regulation of axon extension involved in axon guidance (GO:0048843)4.17457185
24spliceosomal snRNP assembly (GO:0000387)4.16557479
25pericardium development (GO:0060039)4.14792906
26negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)4.12849482
27regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.10221311
28dermatan sulfate biosynthetic process (GO:0030208)4.09857415
29negative regulation of axon guidance (GO:1902668)4.03454496
30establishment of viral latency (GO:0019043)3.99690322
31cellular response to vitamin (GO:0071295)3.99567684
32epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.98416145
33heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.97925857
34primitive streak formation (GO:0090009)3.97370037
35adhesion of symbiont to host cell (GO:0044650)3.93623968
36virion attachment to host cell (GO:0019062)3.93623968
37endodermal cell differentiation (GO:0035987)3.93221365
38regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.92204518
39mesenchymal-epithelial cell signaling (GO:0060638)3.89499757
40ribosome biogenesis (GO:0042254)3.86846751
41substrate-dependent cell migration (GO:0006929)3.84920291
42skin morphogenesis (GO:0043589)3.81385611
43paraxial mesoderm development (GO:0048339)3.80909078
44fat-soluble vitamin catabolic process (GO:0042363)3.79608455
45vitamin catabolic process (GO:0009111)3.79608455
46ribosome assembly (GO:0042255)3.78563073
47tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.78540619
48RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.78540619
49DNA strand elongation involved in DNA replication (GO:0006271)3.77794286
50negative regulation of leukocyte chemotaxis (GO:0002689)3.76975316
51cell adhesion mediated by integrin (GO:0033627)3.74632897
52DNA deamination (GO:0045006)3.73906914
53ribonucleoprotein complex biogenesis (GO:0022613)3.69469341
54metanephric mesenchyme development (GO:0072075)3.69363452
55dermatan sulfate metabolic process (GO:0030205)3.68784199
56negative regulation of osteoblast proliferation (GO:0033689)3.68371125
57otic vesicle formation (GO:0030916)3.66270687
58DNA strand elongation (GO:0022616)3.66179150
59ribosomal large subunit biogenesis (GO:0042273)3.65889122
60negative regulation of androgen receptor signaling pathway (GO:0060766)3.63234738
61bone trabecula formation (GO:0060346)3.61445164
62extracellular regulation of signal transduction (GO:1900115)3.60819121
63extracellular negative regulation of signal transduction (GO:1900116)3.60819121
64extracellular matrix assembly (GO:0085029)3.60422873
65regulation of gene silencing by RNA (GO:0060966)3.59969277
66regulation of posttranscriptional gene silencing (GO:0060147)3.59969277
67regulation of gene silencing by miRNA (GO:0060964)3.59969277
68regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.57871399
69ribosomal small subunit assembly (GO:0000028)3.53080898
70cellular response to vitamin D (GO:0071305)3.52626131
71ribosomal small subunit biogenesis (GO:0042274)3.51900121
72cell migration involved in heart development (GO:0060973)3.49537180
73post-embryonic morphogenesis (GO:0009886)3.47615665
74folic acid-containing compound biosynthetic process (GO:0009396)3.42401103
75proteasome assembly (GO:0043248)3.39803788
76pseudouridine synthesis (GO:0001522)3.38481449
77DNA replication initiation (GO:0006270)3.38042828
78IMP biosynthetic process (GO:0006188)3.38040347
79activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)3.36841171
80viral transcription (GO:0019083)3.35502745
81telomere maintenance via semi-conservative replication (GO:0032201)3.35426106
82neural crest cell development (GO:0014032)3.34849677
83histone H2A acetylation (GO:0043968)3.33269229
84negative regulation of smooth muscle cell migration (GO:0014912)3.30481245
85spliceosomal complex assembly (GO:0000245)3.29131924
86peptidyl-arginine omega-N-methylation (GO:0035247)3.28375907
87translational termination (GO:0006415)3.26991446
88mitotic metaphase plate congression (GO:0007080)3.23626528
89endothelial cell morphogenesis (GO:0001886)3.23458156
90transcription elongation from RNA polymerase III promoter (GO:0006385)3.23414372
91termination of RNA polymerase III transcription (GO:0006386)3.23414372
92positive regulation of axon extension (GO:0045773)3.22596931
93histone arginine methylation (GO:0034969)3.21233086
94single strand break repair (GO:0000012)3.20139675
95negative regulation of cell fate specification (GO:0009996)3.18415239
96response to gravity (GO:0009629)3.17218037
97smooth muscle tissue development (GO:0048745)3.17111389
98regulation of hippo signaling (GO:0035330)3.15877982
99deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.15468390
100deoxyribonucleotide biosynthetic process (GO:0009263)3.13375425
101proteoglycan biosynthetic process (GO:0030166)3.12224933
102lung morphogenesis (GO:0060425)3.10783678
103transcription-coupled nucleotide-excision repair (GO:0006283)3.09961573
104negative regulation of synaptic transmission, GABAergic (GO:0032229)3.09040472
105formation of translation preinitiation complex (GO:0001731)3.08045009
106heart field specification (GO:0003128)3.07994231
107secondary heart field specification (GO:0003139)3.07994231
108negative regulation of BMP signaling pathway (GO:0030514)3.07968899
109viral mRNA export from host cell nucleus (GO:0046784)3.07562623
110termination of RNA polymerase I transcription (GO:0006363)3.07366134
111urinary tract smooth muscle contraction (GO:0014848)3.06397957
112nucleobase biosynthetic process (GO:0046112)3.05902679
113regulation of centriole replication (GO:0046599)3.05664464
114mesonephros development (GO:0001823)3.04971686
115positive regulation of blood vessel endothelial cell migration (GO:0043536)3.03670345
116translational elongation (GO:0006414)3.03346488
117rRNA processing (GO:0006364)3.02984697
118DNA catabolic process, exonucleolytic (GO:0000738)3.01657419
119positive regulation of catecholamine secretion (GO:0033605)3.01436043
120regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.01271975
121adhesion of symbiont to host (GO:0044406)3.01254325
122auditory receptor cell stereocilium organization (GO:0060088)3.00906679
123inner ear receptor cell development (GO:0060119)3.00691877
124CENP-A containing nucleosome assembly (GO:0034080)2.99817680
125telomere maintenance via telomere lengthening (GO:0010833)2.99751298
126tRNA methylation (GO:0030488)2.99696935
127regulation of plasminogen activation (GO:0010755)2.98762594
128heparan sulfate proteoglycan metabolic process (GO:0030201)2.97740371
129transcription elongation from RNA polymerase I promoter (GO:0006362)2.96385726
130regulation of axon guidance (GO:1902667)2.94613774
131actin filament depolymerization (GO:0030042)2.92353318
132morphogenesis of embryonic epithelium (GO:0016331)2.92296582
133positive regulation of protein autophosphorylation (GO:0031954)2.91960795
134ventricular septum development (GO:0003281)2.91505231
135rRNA metabolic process (GO:0016072)2.90695677
136regulation of mitotic spindle checkpoint (GO:1903504)2.89427634
137regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.89427634
138purine nucleobase biosynthetic process (GO:0009113)2.89363178
139regulation of axon extension involved in axon guidance (GO:0048841)2.88503292
140pattern specification involved in kidney development (GO:0061004)2.88200572
1417-methylguanosine mRNA capping (GO:0006370)2.88135763
142chromatin remodeling at centromere (GO:0031055)2.87466304
143sprouting angiogenesis (GO:0002040)2.86588060
144rRNA modification (GO:0000154)2.84538687
145neuron projection extension involved in neuron projection guidance (GO:1902284)2.83628101
146axon extension involved in axon guidance (GO:0048846)2.83628101
147negative regulation of meiosis (GO:0045835)2.83603227
148translational initiation (GO:0006413)2.83354871
149negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.83254430
150regulation of integrin-mediated signaling pathway (GO:2001044)2.81391454
151RNA capping (GO:0036260)2.81130013
1527-methylguanosine RNA capping (GO:0009452)2.81130013
153IMP metabolic process (GO:0046040)2.80613008
154telomere maintenance via recombination (GO:0000722)2.79999093
155DNA replication checkpoint (GO:0000076)2.79782727
156positive regulation of gastrulation (GO:2000543)2.79336603
157exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.79315744
158forebrain morphogenesis (GO:0048853)2.79310536
159positive regulation of fibroblast migration (GO:0010763)2.79286378
160UDP-N-acetylglucosamine metabolic process (GO:0006047)2.78456125
161metaphase plate congression (GO:0051310)2.78244358
162negative regulation of mast cell activation (GO:0033004)2.77684719
163cellular component biogenesis (GO:0044085)2.77340492
164nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.76574780
165artery development (GO:0060840)2.76110723
166regulation of development, heterochronic (GO:0040034)2.74902914
167transcription from RNA polymerase I promoter (GO:0006360)2.74011076
168substrate adhesion-dependent cell spreading (GO:0034446)2.72811261
169positive regulation of cardiac muscle cell differentiation (GO:2000727)2.72397354
170positive regulation of male gonad development (GO:2000020)2.71495618
171pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.70400056
172lens fiber cell development (GO:0070307)2.70212211
173cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.69977575
174anterior/posterior axis specification, embryo (GO:0008595)2.69478787
175response to magnesium ion (GO:0032026)2.68118091
176mesodermal cell differentiation (GO:0048333)2.67644896
177positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.66714697
178regulation of BMP signaling pathway (GO:0030510)2.61492185
179glycoprotein biosynthetic process (GO:0009101)2.60569558
180negative regulation of activin receptor signaling pathway (GO:0032926)2.59892852
181negative regulation of bone remodeling (GO:0046851)2.59631544
182positive regulation of synapse assembly (GO:0051965)2.58315823
183wound healing, spreading of epidermal cells (GO:0035313)2.58059063
184regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.56568069
185axon extension (GO:0048675)2.55205880
186regulation of organ formation (GO:0003156)2.54269726
187regulation of fibroblast migration (GO:0010762)2.52639008
188response to redox state (GO:0051775)2.52561579
189negative regulation of embryonic development (GO:0045992)2.52096614
190blood vessel endothelial cell migration (GO:0043534)2.50425363
191regulation of osteoblast proliferation (GO:0033688)2.49647886
192collagen metabolic process (GO:0032963)2.46349719
193negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.44310952
194proteoglycan metabolic process (GO:0006029)2.43313778
195regulation of male gonad development (GO:2000018)2.42466848
196embryonic cranial skeleton morphogenesis (GO:0048701)2.41591482
197negative chemotaxis (GO:0050919)2.40733085
198atrial septum morphogenesis (GO:0060413)2.37478010
199negative regulation of nitric oxide biosynthetic process (GO:0045019)2.36863997

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.04249101
2MYC_18555785_ChIP-Seq_MESCs_Mouse5.16254497
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.67567115
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.63569371
5SMAD_19615063_ChIP-ChIP_OVARY_Human3.62860745
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.56881888
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.27111061
8BRD4_25478319_ChIP-Seq_HGPS_Human3.15692395
9MYC_18358816_ChIP-ChIP_MESCs_Mouse3.14767432
10MYC_19030024_ChIP-ChIP_MESCs_Mouse3.10938392
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.97975026
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.95298801
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.93401338
14GBX2_23144817_ChIP-Seq_PC3_Human2.90028625
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.89724935
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.88755032
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.86187771
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.81455946
19PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.73748958
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.70958346
21CJUN_26792858_Chip-Seq_BT549_Human2.70942433
22WT1_19549856_ChIP-ChIP_CCG9911_Human2.62043847
23TP63_19390658_ChIP-ChIP_HaCaT_Human2.59939309
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.58437546
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.58020380
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.49782199
27XRN2_22483619_ChIP-Seq_HELA_Human2.47347098
28* EED_16625203_ChIP-ChIP_MESCs_Mouse2.45026829
29CREB1_15753290_ChIP-ChIP_HEK293T_Human2.39498119
30CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.38221063
31TP53_16413492_ChIP-PET_HCT116_Human2.36344633
32FOXM1_23109430_ChIP-Seq_U2OS_Human2.34610261
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.31893896
34TP53_18474530_ChIP-ChIP_U2OS_Human2.31211352
35ZNF274_21170338_ChIP-Seq_K562_Hela2.29425554
36ELF1_17652178_ChIP-ChIP_JURKAT_Human2.23243692
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.22251744
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.21267641
39THAP11_20581084_ChIP-Seq_MESCs_Mouse2.19938244
40EP300_21415370_ChIP-Seq_HL-1_Mouse2.15653152
41POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.13665701
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.12542086
43TTF2_22483619_ChIP-Seq_HELA_Human2.12400807
44PIAS1_25552417_ChIP-Seq_VCAP_Human2.10592523
45YY1_21170310_ChIP-Seq_MESCs_Mouse2.04008796
46NRF2_20460467_ChIP-Seq_MEFs_Mouse2.02893088
47NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.02893088
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.00057557
49E2F1_18555785_ChIP-Seq_MESCs_Mouse1.99441554
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.98313412
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.94730492
52ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.93946756
53* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.93389530
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92909114
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.91140381
56* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.90928988
57ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.90825587
58MYC_18940864_ChIP-ChIP_HL60_Human1.83134271
59KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.82498437
60KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.82498437
61KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.82498437
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.80519617
63VDR_23849224_ChIP-Seq_CD4+_Human1.80412004
64FOXP3_21729870_ChIP-Seq_TREG_Human1.78788820
65E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.78718944
66KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.78340198
67* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.77971790
68* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.77204418
69* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.75323577
70POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.74002571
71JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.69816621
72NANOG_18555785_ChIP-Seq_MESCs_Mouse1.69050673
73P300_19829295_ChIP-Seq_ESCs_Human1.68516066
74YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68283446
75RARG_19884340_ChIP-ChIP_MEFs_Mouse1.68204900
76* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.68165050
77NANOG_16153702_ChIP-ChIP_HESCs_Human1.62836698
78CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61251867
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61165376
80SMAD4_21799915_ChIP-Seq_A2780_Human1.61060531
81POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59015213
82ZNF217_24962896_ChIP-Seq_MCF-7_Human1.58285682
83MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.57975606
84PCGF2_27294783_Chip-Seq_NPCs_Mouse1.57160829
85MYCN_18555785_ChIP-Seq_MESCs_Mouse1.56697817
86ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.55069740
87RBPJ_22232070_ChIP-Seq_NCS_Mouse1.54589876
88CBX2_27304074_Chip-Seq_ESCs_Mouse1.53160734
89NOTCH1_21737748_ChIP-Seq_TLL_Human1.53137871
90* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.53130161
91GABP_19822575_ChIP-Seq_HepG2_Human1.50162456
92* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.48467183
93JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47862030
94EWS_26573619_Chip-Seq_HEK293_Human1.46082108
95* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.44957452
96* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.44643902
97* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.44643902
98TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44479411
99DCP1A_22483619_ChIP-Seq_HELA_Human1.44280373
100HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.41180334
101NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40959422
102* EZH2_27304074_Chip-Seq_ESCs_Mouse1.39310502
103OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39181294
104SOX2_18555785_ChIP-Seq_MESCs_Mouse1.36901754
105* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.36563300
106TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36458102
107E2F1_21310950_ChIP-Seq_MCF-7_Human1.35414780
108IRF1_19129219_ChIP-ChIP_H3396_Human1.35341688
109* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.34991077
110POU5F1_16153702_ChIP-ChIP_HESCs_Human1.34360636
111SRF_21415370_ChIP-Seq_HL-1_Mouse1.33457364
112RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33213334
113SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32419797
114SOX2_16153702_ChIP-ChIP_HESCs_Human1.31493311
115SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31052940
116TAF15_26573619_Chip-Seq_HEK293_Human1.29288588
117SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29045910
118SMAD3_21741376_ChIP-Seq_EPCs_Human1.27899744
119STAT3_23295773_ChIP-Seq_U87_Human1.27683384
120TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.27637472
121RNF2_27304074_Chip-Seq_ESCs_Mouse1.27401594
122SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.27097935
123GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26953406
124FUS_26573619_Chip-Seq_HEK293_Human1.26521755
125EZH2_22144423_ChIP-Seq_EOC_Human1.26386099
126* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.26113737
127ARNT_22903824_ChIP-Seq_MCF-7_Human1.25787652
128BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.25606039
129AR_21909140_ChIP-Seq_LNCAP_Human1.25218686
130MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25137222
131* JUN_21703547_ChIP-Seq_K562_Human1.24847565
132CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24263144
133RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.24112140
134KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.22571485
135MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.22173654
136SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22158627
137POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19975939
138* AR_25329375_ChIP-Seq_VCAP_Human1.19869318
139SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.19819750
140EZH2_27294783_Chip-Seq_NPCs_Mouse1.18061720
141KDM2B_26808549_Chip-Seq_REH_Human1.16007034
142* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.15471167
143RXR_22108803_ChIP-Seq_LS180_Human1.15341175
144AHR_22903824_ChIP-Seq_MCF-7_Human1.14459265
145* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13861637
146CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13470793
147SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.12404582
148* TP53_20018659_ChIP-ChIP_R1E_Mouse1.11413794
149ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10924358
150* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.10459748
151PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human1.10378717
152KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10081091
153ELK1_19687146_ChIP-ChIP_HELA_Human1.08883811
154NANOG_18555785_Chip-Seq_ESCs_Mouse1.06668793
155TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06589374
156EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05576639
157* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.04856106
158MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04751406
159NFE2_27457419_Chip-Seq_LIVER_Mouse1.04463314
160TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03188997
161GATA2_21666600_ChIP-Seq_HMVEC_Human1.02577179
162ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.02223611
163TBX3_20139965_ChIP-Seq_ESCs_Mouse1.02055088
164TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01724951
165CIITA_25753668_ChIP-Seq_RAJI_Human1.01569329
166BCAT_22108803_ChIP-Seq_LS180_Human1.01422506
167NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00940865
168TP53_22127205_ChIP-Seq_IMR90_Human0.99691545
169FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99051163
170RUNX2_22187159_ChIP-Seq_PCA_Human0.99036102
171PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96118532
172ZFX_18555785_ChIP-Seq_MESCs_Mouse0.95188844
173FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94715833
174PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92922804
175RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92659507
176PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89388592
177SOX2_18692474_ChIP-Seq_MEFs_Mouse0.87677815
178SRY_22984422_ChIP-ChIP_TESTIS_Rat0.87274597
179HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.87225605
180VDR_22108803_ChIP-Seq_LS180_Human0.86971342
181* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.86720779
182SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.84275598
183NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.83826104
184YY1_22570637_ChIP-Seq_MALME-3M_Human0.82982968
185CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82485703
186PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.81474299
187FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.81251483
188* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.80094387
189SOX2_18692474_ChIP-Seq_MESCs_Mouse0.79205376
190CTCF_18555785_ChIP-Seq_MESCs_Mouse0.78926683
191* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.76769100
192KDM5A_27292631_Chip-Seq_BREAST_Human0.75616683
193POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.74536800
194ELK1_22589737_ChIP-Seq_MCF10A_Human0.74307223
195TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.73846790

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.62697693
2MP0003890_abnormal_embryonic-extraembry5.01722222
3MP0004133_heterotaxia4.37058517
4MP0006292_abnormal_olfactory_placode4.07955145
5MP0005503_abnormal_tendon_morphology4.00312305
6MP0003950_abnormal_plasma_membrane3.97008285
7MP0003279_aneurysm3.86328784
8MP0001958_emphysema3.77778539
9MP0010030_abnormal_orbit_morphology3.62102524
10MP0003705_abnormal_hypodermis_morpholog3.59456995
11MP0009384_cardiac_valve_regurgitation3.57844286
12MP0008877_abnormal_DNA_methylation3.47153508
13MP0003878_abnormal_ear_physiology3.31224612
14MP0005377_hearing/vestibular/ear_phenot3.31224612
15MP0000678_abnormal_parathyroid_gland3.29241501
16MP0003693_abnormal_embryo_hatching3.24361561
17MP0005257_abnormal_intraocular_pressure3.11099527
18MP0005623_abnormal_meninges_morphology3.08106045
19MP0001542_abnormal_bone_strength2.99084273
20MP0005275_abnormal_skin_tensile2.87298382
21MP0004272_abnormal_basement_membrane2.84907852
22MP0003119_abnormal_digestive_system2.78160715
23MP0010386_abnormal_urinary_bladder2.75475832
24MP0010368_abnormal_lymphatic_system2.72302024
25MP0008058_abnormal_DNA_repair2.69351921
26MP0003077_abnormal_cell_cycle2.65619418
27MP0006054_spinal_hemorrhage2.59304358
28MP0004957_abnormal_blastocyst_morpholog2.58938590
29MP0003111_abnormal_nucleus_morphology2.58515928
30MP0010094_abnormal_chromosome_stability2.54872966
31MP0000566_synostosis2.29144797
32MP0008932_abnormal_embryonic_tissue2.27641352
33MP0000569_abnormal_digit_pigmentation2.19458819
34MP0009250_abnormal_appendicular_skeleto2.16449309
35MP0002160_abnormal_reproductive_system2.12662525
36MP0001299_abnormal_eye_distance/2.10277328
37MP0002653_abnormal_ependyma_morphology2.04997870
38MP0000534_abnormal_ureter_morphology2.02329087
39MP0000767_abnormal_smooth_muscle1.93743083
40MP0000013_abnormal_adipose_tissue1.87887648
41MP0000049_abnormal_middle_ear1.81403602
42MP0002102_abnormal_ear_morphology1.81070503
43MP0008004_abnormal_stomach_pH1.77932730
44MP0008007_abnormal_cellular_replicative1.75294555
45MP0005023_abnormal_wound_healing1.70792710
46MP0009780_abnormal_chondrocyte_physiolo1.70599293
47MP0001293_anophthalmia1.69665250
48MP0005595_abnormal_vascular_smooth1.68416544
49MP0005508_abnormal_skeleton_morphology1.64106712
50MP0003315_abnormal_perineum_morphology1.63453393
51MP0003566_abnormal_cell_adhesion1.60535460
52MP0003937_abnormal_limbs/digits/tail_de1.56946722
53MP0003091_abnormal_cell_migration1.53764673
54MP0002234_abnormal_pharynx_morphology1.52284538
55MP0008789_abnormal_olfactory_epithelium1.52236948
56MP0003941_abnormal_skin_development1.49617118
57MP0002295_abnormal_pulmonary_circulatio1.48690213
58MP0004134_abnormal_chest_morphology1.46506633
59MP0001730_embryonic_growth_arrest1.45097172
60MP0005389_reproductive_system_phenotype1.43176750
61MP0005394_taste/olfaction_phenotype1.39398030
62MP0005499_abnormal_olfactory_system1.39398030
63MP0002938_white_spotting1.37599219
64MP0002111_abnormal_tail_morphology1.33519771
65MP0002638_abnormal_pupillary_reflex1.32351733
66MP0003123_paternal_imprinting1.31825239
67MP0001986_abnormal_taste_sensitivity1.30791196
68MP0002085_abnormal_embryonic_tissue1.28420944
69MP0002896_abnormal_bone_mineralization1.26381384
70MP0005380_embryogenesis_phenotype1.26154799
71MP0001672_abnormal_embryogenesis/_devel1.26154799
72MP0001879_abnormal_lymphatic_vessel1.25422061
73MP0000350_abnormal_cell_proliferation1.25158742
74MP0002751_abnormal_autonomic_nervous1.24318699
75MP0002084_abnormal_developmental_patter1.22539476
76MP0002277_abnormal_respiratory_mucosa1.20460093
77MP0001243_abnormal_dermal_layer1.19314225
78MP0005171_absent_coat_pigmentation1.16637682
79MP0003755_abnormal_palate_morphology1.16045916
80MP0002249_abnormal_larynx_morphology1.15329759
81MP0000428_abnormal_craniofacial_morphol1.14992330
82MP0005423_abnormal_somatic_nervous1.14288868
83MP0009697_abnormal_copulation1.13422606
84MP0001485_abnormal_pinna_reflex1.12637523
85MP0005084_abnormal_gallbladder_morpholo1.09322297
86MP0003283_abnormal_digestive_organ1.09176849
87MP0003718_maternal_effect1.07433710
88MP0002254_reproductive_system_inflammat1.07128989
89MP0000733_abnormal_muscle_development1.05939406
90MP0003942_abnormal_urinary_system1.05893089
91MP0000749_muscle_degeneration1.05049824
92MP0002060_abnormal_skin_morphology1.04587547
93MP0005187_abnormal_penis_morphology1.04420697
94MP0000432_abnormal_head_morphology1.03802654
95MP0001286_abnormal_eye_development1.03781460
96MP0005197_abnormal_uvea_morphology1.03291323
97MP0001348_abnormal_lacrimal_gland1.02704066
98MP0009379_abnormal_foot_pigmentation1.00290010
99MP0003879_abnormal_hair_cell1.00130137
100MP0002282_abnormal_trachea_morphology0.99092184
101MP0003861_abnormal_nervous_system0.98734323
102MP0000537_abnormal_urethra_morphology0.98687812
103MP0001697_abnormal_embryo_size0.98567714
104MP0002132_abnormal_respiratory_system0.98359257
105MP0000163_abnormal_cartilage_morphology0.97768689
106MP0002108_abnormal_muscle_morphology0.97498582
107MP0001529_abnormal_vocalization0.96236273
108MP0003786_premature_aging0.95170556
109MP0002233_abnormal_nose_morphology0.95001288
110MP0003385_abnormal_body_wall0.94613331
111MP0002928_abnormal_bile_duct0.94316678
112MP0003935_abnormal_craniofacial_develop0.93622138
113MP0000516_abnormal_urinary_system0.93594159
114MP0005367_renal/urinary_system_phenotyp0.93594159
115MP0006072_abnormal_retinal_apoptosis0.93356344
116MP0010352_gastrointestinal_tract_polyps0.92685506
117MP0008057_abnormal_DNA_replication0.92212506
118MP0005645_abnormal_hypothalamus_physiol0.92042866
119MP0009672_abnormal_birth_weight0.91717816
120MP0002115_abnormal_skeleton_extremities0.90833549
121MP0003252_abnormal_bile_duct0.90787680
122MP0000026_abnormal_inner_ear0.90003332
123MP0002210_abnormal_sex_determination0.88128244
124MP0002116_abnormal_craniofacial_bone0.86017439
125MP0001919_abnormal_reproductive_system0.85650024
126MP0001188_hyperpigmentation0.85626409
127MP0005390_skeleton_phenotype0.84531045
128MP0000313_abnormal_cell_death0.84248560
129MP0000003_abnormal_adipose_tissue0.84209647
130MP0003984_embryonic_growth_retardation0.83376849
131MP0006276_abnormal_autonomic_nervous0.82607586
132MP0000462_abnormal_digestive_system0.82049587
133MP0000762_abnormal_tongue_morphology0.81400844
134MP0002109_abnormal_limb_morphology0.80928145
135MP0002088_abnormal_embryonic_growth/wei0.80877038
136MP0002080_prenatal_lethality0.80523695
137MP0002168_other_aberrant_phenotype0.79171481
138MP0005620_abnormal_muscle_contractility0.76744046
139MP0003936_abnormal_reproductive_system0.76281511
140MP0000230_abnormal_systemic_arterial0.75610569
141MP0005164_abnormal_response_to0.75125759
142MP0001963_abnormal_hearing_physiology0.75073122
143MP0000470_abnormal_stomach_morphology0.74829453
144MP0002127_abnormal_cardiovascular_syste0.74119476
145MP0002177_abnormal_outer_ear0.73510722
146MP0000751_myopathy0.72143068
147MP0001270_distended_abdomen0.72043777
148MP0002932_abnormal_joint_morphology0.70538037
149MP0009053_abnormal_anal_canal0.69324174
150MP0002128_abnormal_blood_circulation0.68703642
151MP0002113_abnormal_skeleton_development0.68306765
152MP0003121_genomic_imprinting0.68159076
153MP0000631_abnormal_neuroendocrine_gland0.67926326
154MP0002557_abnormal_social/conspecific_i0.67658696
155MP0004742_abnormal_vestibular_system0.66162744
156MP0002752_abnormal_somatic_nervous0.66143290
157MP0001119_abnormal_female_reproductive0.64649942
158MP0000538_abnormal_urinary_bladder0.63637893
159MP0004197_abnormal_fetal_growth/weight/0.62330380
160MP0002114_abnormal_axial_skeleton0.62305608
161MP0003959_abnormal_lean_body0.61926645
162MP0000759_abnormal_skeletal_muscle0.61810436
163MP0005360_urolithiasis0.61618303
164MP0004142_abnormal_muscle_tone0.59959132
165MP0003045_fibrosis0.56632472
166MP0004883_abnormal_blood_vessel0.54002477
167MP0005193_abnormal_anterior_eye0.53110318
168MP0002736_abnormal_nociception_after0.51728322
169MP0000778_abnormal_nervous_system0.51562540
170* MP0000427_abnormal_hair_cycle0.48142757
171MP0001968_abnormal_touch/_nociception0.47871025
172MP0001614_abnormal_blood_vessel0.47452751
173MP0000639_abnormal_adrenal_gland0.47256479
174MP0001664_abnormal_digestion0.46137055

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.93164929
2Protrusio acetabuli (HP:0003179)6.22890435
3Ankle contracture (HP:0006466)5.21099307
4Aortic aneurysm (HP:0004942)5.06404061
5Septo-optic dysplasia (HP:0100842)5.06021266
6Aortic dissection (HP:0002647)4.66140967
7Abdominal situs inversus (HP:0003363)4.54682622
8Abnormality of abdominal situs (HP:0011620)4.54682622
9Type 1 muscle fiber predominance (HP:0003803)4.37973326
10Soft skin (HP:0000977)4.19111833
11Unilateral renal agenesis (HP:0000122)4.13306020
12Abnormality of dentin (HP:0010299)3.99731611
13Parakeratosis (HP:0001036)3.90853238
14Vascular tortuosity (HP:0004948)3.87363144
15Broad metatarsal (HP:0001783)3.78257416
16Slender build (HP:0001533)3.72971520
17Reticulocytopenia (HP:0001896)3.72455067
18Spinal rigidity (HP:0003306)3.65121622
19Bladder diverticulum (HP:0000015)3.58422627
20Chromosomal breakage induced by crosslinking agents (HP:0003221)3.52052363
21Supernumerary spleens (HP:0009799)3.47475598
22Chromsome breakage (HP:0040012)3.45611816
23Hypoventilation (HP:0002791)3.38804802
24Neonatal short-limb short stature (HP:0008921)3.35723638
25Genu recurvatum (HP:0002816)3.33480767
26Asplenia (HP:0001746)3.25955887
27Absent eyelashes (HP:0000561)3.17368615
28Spondylolisthesis (HP:0003302)3.17327993
29Wormian bones (HP:0002645)3.12252715
30Arterial tortuosity (HP:0005116)3.12110812
31Colon cancer (HP:0003003)3.09456469
32Absent/shortened dynein arms (HP:0200106)3.08961671
33Dynein arm defect of respiratory motile cilia (HP:0012255)3.08961671
34Absent eyebrow (HP:0002223)3.00150942
35Optic nerve hypoplasia (HP:0000609)2.99144422
36Aortic regurgitation (HP:0001659)2.98173116
37Birth length less than 3rd percentile (HP:0003561)2.96807708
38Atrophic scars (HP:0001075)2.95930747
39Aplasia/Hypoplasia of the spleen (HP:0010451)2.92431066
40Absent radius (HP:0003974)2.90502958
41Duplicated collecting system (HP:0000081)2.90450247
42Mesomelia (HP:0003027)2.89173650
43Breast aplasia (HP:0100783)2.87606310
44Oral leukoplakia (HP:0002745)2.85362106
45Chronic bronchitis (HP:0004469)2.81095793
46Elbow flexion contracture (HP:0002987)2.80188750
47Absent thumb (HP:0009777)2.78380402
48Horseshoe kidney (HP:0000085)2.78035093
49Aplasia involving forearm bones (HP:0009822)2.76505433
50Absent forearm bone (HP:0003953)2.76505433
51Abnormal respiratory epithelium morphology (HP:0012253)2.76088738
52Abnormal respiratory motile cilium morphology (HP:0005938)2.76088738
53Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.74406991
54Shallow orbits (HP:0000586)2.72767052
55Bowel diverticulosis (HP:0005222)2.71980527
56Absent septum pellucidum (HP:0001331)2.70439280
57Ectopic kidney (HP:0000086)2.69769937
58Aplasia/Hypoplasia of the breasts (HP:0010311)2.67541829
59Peritonitis (HP:0002586)2.65697352
60Aortic valve stenosis (HP:0001650)2.64301061
61Cardiovascular calcification (HP:0011915)2.63836654
62Coronal craniosynostosis (HP:0004440)2.62918376
63Fragile skin (HP:0001030)2.61629363
64Abnormality of the renal collecting system (HP:0004742)2.61381999
65Increased corneal curvature (HP:0100692)2.61380640
66Keratoconus (HP:0000563)2.61380640
67Selective tooth agenesis (HP:0001592)2.59395094
68Abnormality of the septum pellucidum (HP:0007375)2.57880044
69Abnormal ciliary motility (HP:0012262)2.55478297
70Cellular immunodeficiency (HP:0005374)2.52126542
71Cleft eyelid (HP:0000625)2.51819148
72Morphological abnormality of the middle ear (HP:0008609)2.48000065
73Mildly elevated creatine phosphokinase (HP:0008180)2.47977516
74Mitral regurgitation (HP:0001653)2.43937734
75Abnormal lung lobation (HP:0002101)2.43709550
76Biconcave vertebral bodies (HP:0004586)2.43150662
77Wrist flexion contracture (HP:0001239)2.42889227
78Cervical subluxation (HP:0003308)2.42235025
79Abnormality of the preputium (HP:0100587)2.40230947
80Blue sclerae (HP:0000592)2.40111633
81Abnormality of pyrimidine metabolism (HP:0004353)2.40048840
82Facial cleft (HP:0002006)2.38601973
83Wide anterior fontanel (HP:0000260)2.37636998
84Delayed gross motor development (HP:0002194)2.35588494
85Recurrent corneal erosions (HP:0000495)2.35373830
86Optic nerve coloboma (HP:0000588)2.33862949
87Bilateral sensorineural hearing impairment (HP:0008619)2.33821761
88Patellar aplasia (HP:0006443)2.32469699
89Overgrowth (HP:0001548)2.32397539
90Trismus (HP:0000211)2.32292852
91Degeneration of anterior horn cells (HP:0002398)2.31741238
92Abnormality of the anterior horn cell (HP:0006802)2.31741238
93Joint laxity (HP:0001388)2.31507168
94Aplasia/Hypoplasia of the patella (HP:0006498)2.30202161
95Premature graying of hair (HP:0002216)2.28921617
96Progressive external ophthalmoplegia (HP:0000590)2.28648332
97Broad ribs (HP:0000885)2.27986095
98Abnormal number of incisors (HP:0011064)2.27547730
99Renal agenesis (HP:0000104)2.27038935
100Aplasia/Hypoplasia of the uvula (HP:0010293)2.25235720
101Syringomyelia (HP:0003396)2.25180436
102Spinal cord lesions (HP:0100561)2.25180436
103Hyperextensible skin (HP:0000974)2.24655287
104Increased number of teeth (HP:0011069)2.24521685
105Rib fusion (HP:0000902)2.23071131
106Bradycardia (HP:0001662)2.22870599
107Dilatation of the ascending aorta (HP:0005111)2.21611875
108Limb-girdle muscle weakness (HP:0003325)2.19599287
109Mitral stenosis (HP:0001718)2.19439531
110Intestinal atresia (HP:0011100)2.18947850
111Breast hypoplasia (HP:0003187)2.18356478
112Aplasia of the musculature (HP:0100854)2.18307741
113Abnormality of dental color (HP:0011073)2.17792311
114Knee flexion contracture (HP:0006380)2.17427202
115Meckel diverticulum (HP:0002245)2.15836486
116Joint stiffness (HP:0001387)2.15217337
117Long toe (HP:0010511)2.14817052
118Alopecia of scalp (HP:0002293)2.14027953
119Triphalangeal thumb (HP:0001199)2.12186386
120Abnormality of DNA repair (HP:0003254)2.12145079
121Round ear (HP:0100830)2.09948542
122Medulloblastoma (HP:0002885)2.09416045
123Camptodactyly of toe (HP:0001836)2.08280849
124Hypoplastic pelvis (HP:0008839)2.07748785
125Tracheoesophageal fistula (HP:0002575)2.06307248
126Increased serum pyruvate (HP:0003542)2.06263927
127Abnormality of glycolysis (HP:0004366)2.06263927
128Abnormality of the ileum (HP:0001549)2.05842950
129Redundant skin (HP:0001582)2.01637966
130Renal duplication (HP:0000075)2.01430101
131Mitral valve prolapse (HP:0001634)2.00782122
132Anomalous pulmonary venous return (HP:0010772)1.98879025
133Double outlet right ventricle (HP:0001719)1.98878439
134Congenital malformation of the right heart (HP:0011723)1.98878439
135Cerebral hypomyelination (HP:0006808)1.98703544
136Ovoid vertebral bodies (HP:0003300)1.98087932
137Severe visual impairment (HP:0001141)1.96162996
138Follicular hyperkeratosis (HP:0007502)1.96091054
139Macrocytic anemia (HP:0001972)1.95459172
140Type 2 muscle fiber atrophy (HP:0003554)1.94473666
141Decreased subcutaneous fat (HP:0001002)1.94072486
142Absent hair (HP:0002298)1.93625854
143Sparse eyelashes (HP:0000653)1.93462803
144Rough bone trabeculation (HP:0100670)1.92926997
145Entropion (HP:0000621)1.92903851
146True hermaphroditism (HP:0010459)1.92501129
147Pallor (HP:0000980)1.90703814
148Reduced subcutaneous adipose tissue (HP:0003758)1.90369790
149Pancreatic cysts (HP:0001737)1.89293725
150Microretrognathia (HP:0000308)1.86515743
151Agnosia (HP:0010524)1.86285728
15211 pairs of ribs (HP:0000878)1.86042706
153Flat cornea (HP:0007720)1.84716201
154Deviation of the hallux (HP:0010051)1.84624622
155Pendular nystagmus (HP:0012043)1.84153785
156Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.83255326
157Shawl scrotum (HP:0000049)1.82485964
158Pancytopenia (HP:0001876)1.81452125
159Erectile abnormalities (HP:0100639)1.81405060
160Aplasia/Hypoplasia of the sacrum (HP:0008517)1.81363836
161Anal stenosis (HP:0002025)1.80815030
162Infantile muscular hypotonia (HP:0008947)1.80776254
163Occipital encephalocele (HP:0002085)1.80540605
164Protruding ear (HP:0000411)1.79132565
165Short nail (HP:0001799)1.78926053
166Hypoplasia of the capital femoral epiphysis (HP:0003090)1.78319234
167Abnormality of the acetabulum (HP:0003170)1.78198290
168Preaxial hand polydactyly (HP:0001177)1.77862562
169Duplication of thumb phalanx (HP:0009942)1.77334781
170Hydroxyprolinuria (HP:0003080)1.76936013
171Abnormality of proline metabolism (HP:0010907)1.76936013
172Pancreatic fibrosis (HP:0100732)1.76578567
173Femoral bowing (HP:0002980)1.75855618
174Absent frontal sinuses (HP:0002688)1.75283463
175Hallux valgus (HP:0001822)1.74900312
176Abnormal connection of the cardiac segments (HP:0011545)1.74224138
177Generalized amyotrophy (HP:0003700)1.73259282
178Increased variability in muscle fiber diameter (HP:0003557)1.71239616
179Delayed closure of the anterior fontanelle (HP:0001476)1.70567713
180Radial bowing (HP:0002986)1.68751515
181Broad long bones (HP:0005622)1.68404161
182Flared iliac wings (HP:0002869)1.68005598
183Abnormal delivery (HP:0001787)1.66444811
184Bowed forearm bones (HP:0003956)1.65362146
185Bowing of the arm (HP:0006488)1.65362146
186Tarsal synostosis (HP:0008368)1.62941686
187Vascular calcification (HP:0004934)1.60238025
188Limited hip movement (HP:0008800)1.59300642
189Synostosis involving bones of the lower limbs (HP:0009138)1.58946217
190Synostosis involving bones of the feet (HP:0009140)1.58946217
191Bulbous nose (HP:0000414)1.58765649
192Vertebral compression fractures (HP:0002953)1.58564505
193Hip contracture (HP:0003273)1.58218108
194Prominent supraorbital ridges (HP:0000336)1.57509777
195Tibial bowing (HP:0002982)1.57388927
196Molar tooth sign on MRI (HP:0002419)1.57299395
197Abnormality of midbrain morphology (HP:0002418)1.57299395

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK4.71737942
2AKT34.50415425
3BUB14.31172548
4FRK3.97567070
5EIF2AK13.53621939
6SIK33.50947075
7CDC73.46950735
8LIMK13.16536280
9LATS23.09125703
10PLK42.97153821
11NEK92.94071007
12DDR22.92950032
13TSSK62.65720374
14EPHA22.60700549
15SRPK12.54125324
16PTK22.51734072
17PAK22.47508899
18MKNK12.38363874
19WEE12.28671989
20PDGFRA2.27414807
21STK382.07032391
22STK162.06642967
23STK38L2.05319624
24VRK12.04265932
25GRK72.00723809
26PAK41.99232409
27PRKD21.96226875
28ADRBK11.90765621
29CDK71.84260772
30PTK2B1.82786632
31PAK61.78870990
32BRD41.78353808
33TTN1.75628578
34PLK31.74621542
35PASK1.70043239
36FLT31.66898428
37EIF2AK21.64826067
38MKNK21.61103004
39PIK3CG1.58204734
40TRPM71.48858500
41GRK11.48003853
42TTK1.43905224
43ERBB41.42721887
44PLK11.42233231
45SIK21.41195207
46TLK11.40837289
47MOS1.40637522
48NTRK11.39552168
49TGFBR21.38643990
50ATR1.34536058
51MAP3K111.34072393
52WNK41.32587494
53IRAK21.30975232
54IRAK31.30611027
55NEK21.29653305
56AURKA1.25704600
57CASK1.22310987
58MET1.19188798
59TESK21.18552973
60ROCK11.16721114
61BRAF1.16284012
62MELK1.15967252
63EIF2AK31.15720870
64PAK31.14883246
65NTRK31.12942351
66TAOK21.10553450
67PDGFRB1.09602241
68PNCK1.09195801
69CDK81.08638932
70AURKB1.07744228
71PRKCE1.06075902
72DYRK21.02496668
73NME10.96870399
74CHEK10.95804896
75PRPF4B0.94023430
76INSRR0.92205177
77MAP2K60.92131250
78WNK10.92018370
79BRSK20.91614554
80TGFBR10.90940338
81YES10.88519118
82MAP3K80.88488675
83ACVR1B0.86996714
84STK30.83939602
85MAP2K10.83876702
86ZAK0.81483243
87ROCK20.80148197
88MARK10.80139909
89CHEK20.78421459
90DAPK10.77880290
91PRKG20.76590094
92CDK190.73770885
93MAP2K30.72884625
94RPS6KA40.72270052
95CSNK2A20.71825509
96MARK30.71216168
97KDR0.69492789
98CAMKK20.69452758
99NUAK10.68956099
100ILK0.68650913
101CSNK2A10.66989800
102DMPK0.65196551
103STK100.62601717
104GSK3A0.62544530
105SIK10.61342431
106MAP2K20.61086938
107BCR0.60675965
108CSNK1E0.59696472
109ADRBK20.59006494
110LATS10.57308353
111TNIK0.56064445
112PRKCH0.55090100
113ICK0.54477031
114PINK10.53172890
115FGFR10.52502243
116CAMK2A0.52288652
117PIK3CA0.50609881
118CDK20.50388698
119TESK10.50204320
120ATM0.49566157
121STK40.49419263
122CDC42BPA0.48996805
123MAP2K70.48673787
124MAPK150.48613609
125ALK0.48474897
126MAPK130.46869568
127EPHB20.46434648
128PBK0.46415668
129DYRK30.45331824
130PAK10.45100879
131PRKD30.44642022
132EPHA40.43219755
133CDK10.41912969
134RPS6KB20.41764336
135MAP3K120.40347133
136IRAK40.40022414
137MAP3K70.39557578
138RPS6KA50.39510638
139MAP3K30.38797732
140NEK60.38205899
141MAP3K60.37812344
142BMPR1B0.37783382
143PRKG10.37099782
144RPS6KA20.36763553
145AKT20.36328127
146PLK20.36119711
147MAPKAPK30.35430250
148BCKDK0.35375740
149WNK30.34414170
150ERBB30.33788456
151MAP3K40.32570187
152CAMK10.31395954
153ABL10.30143767
154MAPK70.29538329
155PRKDC0.29485476
156NEK10.28572428
157DAPK30.28269463
158DYRK1B0.27259851
159ABL20.26692704
160IRAK10.26449512
161PKN10.26347910
162MAPKAPK20.25792341
163CHUK0.25425185
164NLK0.25071199
165INSR0.24784044
166PRKD10.24718791
167CAMK2B0.24217487
168CAMK2G0.23870074
169CDK40.23373482
170PRKCG0.23249466

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.48137929
2Mismatch repair_Homo sapiens_hsa034304.23358145
3RNA polymerase_Homo sapiens_hsa030204.03641207
4Ribosome_Homo sapiens_hsa030103.95289043
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.70105023
6Proteasome_Homo sapiens_hsa030503.66905529
7Spliceosome_Homo sapiens_hsa030403.65461411
8ECM-receptor interaction_Homo sapiens_hsa045123.62157228
9Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005343.57081995
10Homologous recombination_Homo sapiens_hsa034403.35465676
11One carbon pool by folate_Homo sapiens_hsa006703.07096957
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.80294998
13Focal adhesion_Homo sapiens_hsa045102.72128826
14Base excision repair_Homo sapiens_hsa034102.69189777
15RNA transport_Homo sapiens_hsa030132.66402766
16Pyrimidine metabolism_Homo sapiens_hsa002402.57481387
17Nucleotide excision repair_Homo sapiens_hsa034202.53217760
18Fanconi anemia pathway_Homo sapiens_hsa034602.51670502
19Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.17746896
20Basal transcription factors_Homo sapiens_hsa030222.01547349
21RNA degradation_Homo sapiens_hsa030181.97668164
22Cell cycle_Homo sapiens_hsa041101.88955181
23Basal cell carcinoma_Homo sapiens_hsa052171.88243111
24Dilated cardiomyopathy_Homo sapiens_hsa054141.79344954
25Non-homologous end-joining_Homo sapiens_hsa034501.78226431
26Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.75811268
27Protein digestion and absorption_Homo sapiens_hsa049741.74191259
28Proteoglycans in cancer_Homo sapiens_hsa052051.73661324
29* Regulation of actin cytoskeleton_Homo sapiens_hsa048101.67724232
30Cocaine addiction_Homo sapiens_hsa050301.67478652
31Purine metabolism_Homo sapiens_hsa002301.57593071
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.49822088
33mRNA surveillance pathway_Homo sapiens_hsa030151.49085803
34Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.41345758
35Hedgehog signaling pathway_Homo sapiens_hsa043401.40984109
36Vascular smooth muscle contraction_Homo sapiens_hsa042701.31990896
37p53 signaling pathway_Homo sapiens_hsa041151.25596345
38Dorso-ventral axis formation_Homo sapiens_hsa043201.25359719
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.23350623
40Insulin secretion_Homo sapiens_hsa049111.20906619
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15275334
42Sulfur metabolism_Homo sapiens_hsa009201.12356651
43Bladder cancer_Homo sapiens_hsa052191.09960408
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08159506
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.07675542
46Hippo signaling pathway_Homo sapiens_hsa043901.03851734
47cAMP signaling pathway_Homo sapiens_hsa040241.02655411
48Glutamatergic synapse_Homo sapiens_hsa047241.02058563
49Gap junction_Homo sapiens_hsa045401.01288480
50cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00584563
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.98576432
52Amoebiasis_Homo sapiens_hsa051460.97696896
53Wnt signaling pathway_Homo sapiens_hsa043100.97486139
54Nicotine addiction_Homo sapiens_hsa050330.92484278
55Cholinergic synapse_Homo sapiens_hsa047250.92239667
56GABAergic synapse_Homo sapiens_hsa047270.91031130
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90391711
58Nitrogen metabolism_Homo sapiens_hsa009100.86754515
59Oxytocin signaling pathway_Homo sapiens_hsa049210.86136110
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85914722
61Dopaminergic synapse_Homo sapiens_hsa047280.85777977
62Salivary secretion_Homo sapiens_hsa049700.85148445
63Huntingtons disease_Homo sapiens_hsa050160.85093945
64Small cell lung cancer_Homo sapiens_hsa052220.84969685
65Olfactory transduction_Homo sapiens_hsa047400.82368855
66Epstein-Barr virus infection_Homo sapiens_hsa051690.81231759
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78861813
68Biosynthesis of amino acids_Homo sapiens_hsa012300.78493086
69Oocyte meiosis_Homo sapiens_hsa041140.78382427
70* Ras signaling pathway_Homo sapiens_hsa040140.78351045
71* MAPK signaling pathway_Homo sapiens_hsa040100.77198491
72Circadian entrainment_Homo sapiens_hsa047130.76988090
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74791010
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71620307
75N-Glycan biosynthesis_Homo sapiens_hsa005100.71523645
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.69307097
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68031499
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67678903
79Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66722212
80Cardiac muscle contraction_Homo sapiens_hsa042600.66229060
81Systemic lupus erythematosus_Homo sapiens_hsa053220.64961778
82Amphetamine addiction_Homo sapiens_hsa050310.63274195
83Long-term depression_Homo sapiens_hsa047300.61234025
84TGF-beta signaling pathway_Homo sapiens_hsa043500.60300220
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60142484
86TNF signaling pathway_Homo sapiens_hsa046680.59531527
87Renin secretion_Homo sapiens_hsa049240.59351833
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59158148
89Melanogenesis_Homo sapiens_hsa049160.59146261
90Shigellosis_Homo sapiens_hsa051310.57257950
91Gastric acid secretion_Homo sapiens_hsa049710.57041722
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56103280
93Phenylalanine metabolism_Homo sapiens_hsa003600.56091799
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55500347
95* Melanoma_Homo sapiens_hsa052180.55421256
96Sphingolipid metabolism_Homo sapiens_hsa006000.54794309
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54599939
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54142380
99MicroRNAs in cancer_Homo sapiens_hsa052060.53770808
100HTLV-I infection_Homo sapiens_hsa051660.51076099
101Platelet activation_Homo sapiens_hsa046110.50297952
102Thyroid hormone synthesis_Homo sapiens_hsa049180.49623027
103Oxidative phosphorylation_Homo sapiens_hsa001900.48199453
104Phototransduction_Homo sapiens_hsa047440.47984520
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47855295
106Protein export_Homo sapiens_hsa030600.44415381
107Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42958875
108Retinol metabolism_Homo sapiens_hsa008300.42012378
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.41057145
110Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.40570015
111Thyroid cancer_Homo sapiens_hsa052160.39937496
112Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37801887
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37774152
114Axon guidance_Homo sapiens_hsa043600.37122095
115Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35954920
116Maturity onset diabetes of the young_Homo sapiens_hsa049500.35140292
117Herpes simplex infection_Homo sapiens_hsa051680.34781009
118Ether lipid metabolism_Homo sapiens_hsa005650.34774063
119Estrogen signaling pathway_Homo sapiens_hsa049150.34569237
120Parkinsons disease_Homo sapiens_hsa050120.33687372
121Folate biosynthesis_Homo sapiens_hsa007900.32366587
122Tyrosine metabolism_Homo sapiens_hsa003500.31219459
123Arginine and proline metabolism_Homo sapiens_hsa003300.29783063
124* Pathways in cancer_Homo sapiens_hsa052000.28540370
125SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27931785
126Metabolic pathways_Homo sapiens_hsa011000.27874692
127Notch signaling pathway_Homo sapiens_hsa043300.27476256
128Autoimmune thyroid disease_Homo sapiens_hsa053200.27018741
129Alcoholism_Homo sapiens_hsa050340.25066997
130Arachidonic acid metabolism_Homo sapiens_hsa005900.23392844
131Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.23032117
132Adherens junction_Homo sapiens_hsa045200.22843034
133Glutathione metabolism_Homo sapiens_hsa004800.22476471
134Tight junction_Homo sapiens_hsa045300.21825849
135Type I diabetes mellitus_Homo sapiens_hsa049400.21661836
136HIF-1 signaling pathway_Homo sapiens_hsa040660.20114640
137Selenocompound metabolism_Homo sapiens_hsa004500.19851281
138Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.16855220
139Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.16837687
140Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.16353850
141Transcriptional misregulation in cancer_Homo sapiens_hsa052020.15944810
142Sulfur relay system_Homo sapiens_hsa041220.15005991
143Viral carcinogenesis_Homo sapiens_hsa052030.14185060
144Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.13682867
145Serotonergic synapse_Homo sapiens_hsa047260.13670433
146Allograft rejection_Homo sapiens_hsa053300.13434724
147Taste transduction_Homo sapiens_hsa047420.12555956
148Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.11253816
149Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.10678157
150Morphine addiction_Homo sapiens_hsa050320.10556168
151Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.10372340
152Linoleic acid metabolism_Homo sapiens_hsa005910.09493500
153Drug metabolism - other enzymes_Homo sapiens_hsa009830.09198989
154Calcium signaling pathway_Homo sapiens_hsa040200.08894167
155Synaptic vesicle cycle_Homo sapiens_hsa047210.07768057
156Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.06081528
157* Rap1 signaling pathway_Homo sapiens_hsa040150.05538469
158Central carbon metabolism in cancer_Homo sapiens_hsa052300.04952927
159* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.04087831

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