FGF6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene displayed oncogenic transforming activity when transfected into mammalian cells. The mouse homolog of this gene exhibits a restricted expression profile predominantly in the myogenic lineage, which suggested a role in muscle regeneration or differentiation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)4.58233409
2presynaptic membrane organization (GO:0097090)4.46234139
3neuron cell-cell adhesion (GO:0007158)4.16022830
4negative regulation of synaptic transmission, GABAergic (GO:0032229)3.98828499
5regulation of timing of cell differentiation (GO:0048505)3.80387448
6positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.78132689
7neuronal action potential propagation (GO:0019227)3.74894984
8negative regulation of protein localization to cell surface (GO:2000009)3.73335508
9righting reflex (GO:0060013)3.67243848
10keratinocyte development (GO:0003334)3.58778967
11limb bud formation (GO:0060174)3.57724928
12gamma-aminobutyric acid signaling pathway (GO:0007214)3.57587514
13long-chain fatty acid biosynthetic process (GO:0042759)3.57388858
14retina layer formation (GO:0010842)3.51824107
15axon ensheathment in central nervous system (GO:0032291)3.49962705
16central nervous system myelination (GO:0022010)3.49962705
17ionotropic glutamate receptor signaling pathway (GO:0035235)3.46863596
18cerebral cortex radially oriented cell migration (GO:0021799)3.46174091
19cranial nerve morphogenesis (GO:0021602)3.42993054
20positive regulation of action potential (GO:0045760)3.42266281
21glutamate receptor signaling pathway (GO:0007215)3.37852440
22regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.35395516
23L-amino acid import (GO:0043092)3.32411181
24G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.31508659
25epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.27484439
26postsynaptic membrane organization (GO:0001941)3.25653450
27response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.22468318
28neuron recognition (GO:0008038)3.21049989
29import into cell (GO:0098657)3.19610305
30vocalization behavior (GO:0071625)3.16713177
31negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.15294575
32regulation of development, heterochronic (GO:0040034)3.13958250
33cornea development in camera-type eye (GO:0061303)3.13826817
34positive regulation of cardiac muscle cell differentiation (GO:2000727)3.11098025
35neuron-neuron synaptic transmission (GO:0007270)3.11041722
36motile cilium assembly (GO:0044458)3.10213098
37regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.06291141
38calcium ion import (GO:0070509)3.05247699
39positive regulation of synapse assembly (GO:0051965)3.05111429
40positive regulation of protein kinase C signaling (GO:0090037)3.02119152
41short-term memory (GO:0007614)2.98905636
42sympathetic nervous system development (GO:0048485)2.94778986
43negative regulation of neurotransmitter transport (GO:0051589)2.93613257
44regulation of inositol phosphate biosynthetic process (GO:0010919)2.93328717
45neuron remodeling (GO:0016322)2.90655186
46startle response (GO:0001964)2.90453988
47cellular response to epinephrine stimulus (GO:0071872)2.89459884
48membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.87570191
49synaptic transmission, glutamatergic (GO:0035249)2.86672326
50regulation of pigment cell differentiation (GO:0050932)2.86641836
51transmission of nerve impulse (GO:0019226)2.85750535
52reflex (GO:0060004)2.83205604
53response to epinephrine (GO:0071871)2.82658807
54positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.79110919
55regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.78742934
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.78086760
57fatty acid elongation (GO:0030497)2.77516499
58regulation of synapse assembly (GO:0051963)2.76980903
59organ growth (GO:0035265)2.76237384
60regulation of glutamate receptor signaling pathway (GO:1900449)2.76074969
61neurotransmitter-gated ion channel clustering (GO:0072578)2.69419195
62head development (GO:0060322)2.67175430
63regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.60447733
64otic vesicle formation (GO:0030916)2.58812506
65spinal cord motor neuron differentiation (GO:0021522)2.57676793
66protein localization to synapse (GO:0035418)2.56934037
67regulation of cardiac muscle cell differentiation (GO:2000725)2.56205094
68amino acid import (GO:0043090)2.53643609
69negative regulation of skeletal muscle tissue development (GO:0048642)2.52897939
70photoreceptor cell differentiation (GO:0046530)2.49971343
71eye photoreceptor cell differentiation (GO:0001754)2.49971343
72axonal fasciculation (GO:0007413)2.49736008
73cerebral cortex cell migration (GO:0021795)2.49491443
74regulation of synaptic transmission, glutamatergic (GO:0051966)2.49317006
75regulation of respiratory gaseous exchange (GO:0043576)2.47859910
76forebrain neuron development (GO:0021884)2.46488115
77regulation of synaptic transmission, GABAergic (GO:0032228)2.44306613
78negative regulation of neurotransmitter secretion (GO:0046929)2.44105471
79cranial nerve development (GO:0021545)2.43955571
80positive regulation of vascular permeability (GO:0043117)2.43049292
81cAMP-mediated signaling (GO:0019933)2.41973898
82negative regulation of synaptic transmission (GO:0050805)2.41033011
83negative regulation of homotypic cell-cell adhesion (GO:0034111)2.40550178
84regulation of excitatory postsynaptic membrane potential (GO:0060079)2.37313088
85neuromuscular synaptic transmission (GO:0007274)2.36351660
86glycine transport (GO:0015816)2.35393650
87axonemal dynein complex assembly (GO:0070286)2.34709687
88regulation of collateral sprouting (GO:0048670)2.34049093
89epithelial cilium movement (GO:0003351)2.33495388
90regulation of postsynaptic membrane potential (GO:0060078)2.33326021
91polyol transport (GO:0015791)2.33072337
92cilium movement (GO:0003341)2.32929366
93regulation of memory T cell differentiation (GO:0043380)2.32622038
94membrane assembly (GO:0071709)2.31552373
95gamma-aminobutyric acid transport (GO:0015812)2.31165772
96negative regulation of execution phase of apoptosis (GO:1900118)2.31007563
97regulation of short-term neuronal synaptic plasticity (GO:0048172)2.30495105
98dendrite development (GO:0016358)2.29141836
99male sex determination (GO:0030238)2.27974082
100membrane depolarization during action potential (GO:0086010)2.27823074

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.20532627
2GBX2_23144817_ChIP-Seq_PC3_Human4.04854296
3TAF15_26573619_Chip-Seq_HEK293_Human2.63436968
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.63192753
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.62740251
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.49458422
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.46194567
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.45433745
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.42597260
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.31284318
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.29924323
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23869718
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.22301050
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.20456542
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.17707842
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.17707842
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.15722500
18BMI1_23680149_ChIP-Seq_NPCS_Mouse2.14851148
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.09366998
20CBX2_27304074_Chip-Seq_ESCs_Mouse2.07352546
21VDR_22108803_ChIP-Seq_LS180_Human2.06834765
22AR_21572438_ChIP-Seq_LNCaP_Human2.00931269
23PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.91959207
24* EZH2_27294783_Chip-Seq_ESCs_Mouse1.87966368
25MTF2_20144788_ChIP-Seq_MESCs_Mouse1.87764311
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85473934
27P300_19829295_ChIP-Seq_ESCs_Human1.83393773
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83097363
29SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.81781106
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.78855751
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78322043
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.77278082
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.75678700
34* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.73404796
35FUS_26573619_Chip-Seq_HEK293_Human1.73386680
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.73166538
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.63807690
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.63295229
39SMAD3_21741376_ChIP-Seq_EPCs_Human1.62973916
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.61715192
41SMAD4_21799915_ChIP-Seq_A2780_Human1.60808291
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59656127
43RNF2_27304074_Chip-Seq_NSC_Mouse1.57750658
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.57197835
45IGF1R_20145208_ChIP-Seq_DFB_Human1.53960247
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.51743476
47TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.47060541
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46325586
49NANOG_18555785_Chip-Seq_ESCs_Mouse1.46288143
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44592709
51ER_23166858_ChIP-Seq_MCF-7_Human1.43268204
52EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.42976801
53DROSHA_22980978_ChIP-Seq_HELA_Human1.42863863
54* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42644469
55REST_21632747_ChIP-Seq_MESCs_Mouse1.41829357
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.41653968
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40623384
58TP53_16413492_ChIP-PET_HCT116_Human1.38872046
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.37031926
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36207983
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35750432
62IKZF1_21737484_ChIP-ChIP_HCT116_Human1.35577115
63E2F1_18555785_Chip-Seq_ESCs_Mouse1.34745372
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34417513
65P53_22387025_ChIP-Seq_ESCs_Mouse1.30936497
66SUZ12_18555785_Chip-Seq_ESCs_Mouse1.29712323
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28556555
68WT1_19549856_ChIP-ChIP_CCG9911_Human1.28544917
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.27687082
70CMYC_18555785_Chip-Seq_ESCs_Mouse1.26067052
71STAT3_23295773_ChIP-Seq_U87_Human1.23859077
72TP53_18474530_ChIP-ChIP_U2OS_Human1.22578129
73STAT3_18555785_Chip-Seq_ESCs_Mouse1.21001731
74CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20940393
75AR_25329375_ChIP-Seq_VCAP_Human1.20500762
76TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20245797
77EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.19977422
78TCF4_23295773_ChIP-Seq_U87_Human1.17191642
79P300_18555785_Chip-Seq_ESCs_Mouse1.16197145
80ARNT_22903824_ChIP-Seq_MCF-7_Human1.14555945
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14355843
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14355843
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13897532
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13736271
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13359143
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13296062
87RUNX1_27457419_Chip-Seq_LIVER_Mouse1.12265852
88CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.12142600
89ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11812320
90RUNX2_22187159_ChIP-Seq_PCA_Human1.11102166
91SOX2_18555785_Chip-Seq_ESCs_Mouse1.10584211
92NMYC_18555785_Chip-Seq_ESCs_Mouse1.10284936
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.08901292
94ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08535483
95OCT4_18555785_Chip-Seq_ESCs_Mouse1.08076436
96* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.05564374
97AHR_22903824_ChIP-Seq_MCF-7_Human1.05238193
98LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03933527
99KLF4_18555785_Chip-Seq_ESCs_Mouse1.03113367
100VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01546122

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.45620224
2MP0003880_abnormal_central_pattern3.34371887
3MP0001188_hyperpigmentation3.09362434
4MP0003136_yellow_coat_color2.64542378
5MP0000566_synostosis2.61770083
6MP0001486_abnormal_startle_reflex2.46535356
7MP0006292_abnormal_olfactory_placode2.43672764
8MP0009046_muscle_twitch2.38499632
9MP0005409_darkened_coat_color2.36552591
10MP0004859_abnormal_synaptic_plasticity2.34563744
11MP0001968_abnormal_touch/_nociception2.32532417
12MP0009745_abnormal_behavioral_response2.31744862
13MP0003635_abnormal_synaptic_transmissio2.29384688
14MP0002736_abnormal_nociception_after2.25023938
15MP0002249_abnormal_larynx_morphology2.11072183
16MP0002272_abnormal_nervous_system2.02123895
17MP0002735_abnormal_chemical_nociception2.02118558
18MP0002064_seizures2.02096955
19MP0005423_abnormal_somatic_nervous2.01611297
20MP0009780_abnormal_chondrocyte_physiolo1.95980956
21MP0001440_abnormal_grooming_behavior1.94069772
22MP0004145_abnormal_muscle_electrophysio1.91193987
23MP0004142_abnormal_muscle_tone1.88630254
24MP0002572_abnormal_emotion/affect_behav1.86833947
25MP0004270_analgesia1.80248692
26MP0002063_abnormal_learning/memory/cond1.77337197
27MP0002067_abnormal_sensory_capabilities1.77009498
28MP0003950_abnormal_plasma_membrane1.67860371
29MP0003938_abnormal_ear_development1.67584260
30MP0004742_abnormal_vestibular_system1.63876724
31MP0002734_abnormal_mechanical_nocicepti1.60200055
32MP0003787_abnormal_imprinting1.59634202
33MP0001501_abnormal_sleep_pattern1.56250333
34MP0001529_abnormal_vocalization1.55036930
35MP0005171_absent_coat_pigmentation1.54698254
36MP0005646_abnormal_pituitary_gland1.48955734
37MP0005551_abnormal_eye_electrophysiolog1.44143288
38MP0000026_abnormal_inner_ear1.43985972
39MP0000778_abnormal_nervous_system1.43283169
40MP0002557_abnormal_social/conspecific_i1.40421864
41MP0010386_abnormal_urinary_bladder1.38990990
42MP0001905_abnormal_dopamine_level1.36709063
43MP0001963_abnormal_hearing_physiology1.34812128
44MP0005670_abnormal_white_adipose1.34224457
45MP0000049_abnormal_middle_ear1.32720747
46MP0002837_dystrophic_cardiac_calcinosis1.29909636
47MP0005379_endocrine/exocrine_gland_phen1.29804951
48MP0001984_abnormal_olfaction1.29416945
49MP0001485_abnormal_pinna_reflex1.28729466
50MP0002184_abnormal_innervation1.26908001
51MP0006072_abnormal_retinal_apoptosis1.25983591
52MP0006276_abnormal_autonomic_nervous1.25729275
53MP0001970_abnormal_pain_threshold1.25604526
54MP0004381_abnormal_hair_follicle1.25000762
55MP0000751_myopathy1.22686225
56MP0000631_abnormal_neuroendocrine_gland1.21512503
57MP0002638_abnormal_pupillary_reflex1.20012954
58MP0002822_catalepsy1.18777946
59MP0001661_extended_life_span1.14588295
60MP0002752_abnormal_somatic_nervous1.13339712
61MP0002733_abnormal_thermal_nociception1.12774046
62MP0000920_abnormal_myelination1.12458971
63MP0000462_abnormal_digestive_system1.11480988
64MP0001986_abnormal_taste_sensitivity1.08128045
65MP0003183_abnormal_peptide_metabolism1.07613949
66MP0008569_lethality_at_weaning1.05923463
67MP0002882_abnormal_neuron_morphology1.05328610
68MP0009250_abnormal_appendicular_skeleto1.05030148
69MP0005645_abnormal_hypothalamus_physiol1.04960180
70MP0008260_abnormal_autophagy1.03777899
71MP0001727_abnormal_embryo_implantation1.01125397
72MP0005386_behavior/neurological_phenoty0.99136517
73MP0004924_abnormal_behavior0.99136517
74MP0002066_abnormal_motor_capabilities/c0.98606902
75MP0002876_abnormal_thyroid_physiology0.97146979
76MP0005253_abnormal_eye_physiology0.96712110
77MP0003879_abnormal_hair_cell0.96496136
78MP0004215_abnormal_myocardial_fiber0.96410100
79MP0005451_abnormal_body_composition0.94994586
80MP0000762_abnormal_tongue_morphology0.93586258
81MP0009379_abnormal_foot_pigmentation0.90682301
82MP0001664_abnormal_digestion0.90087720
83MP0005623_abnormal_meninges_morphology0.89432870
84MP0001502_abnormal_circadian_rhythm0.88601060
85MP0000678_abnormal_parathyroid_gland0.88109842
86MP0000749_muscle_degeneration0.87985832
87MP0004085_abnormal_heartbeat0.85686739
88MP0002277_abnormal_respiratory_mucosa0.83535395
89MP0004885_abnormal_endolymph0.83136973
90MP0002229_neurodegeneration0.82331244
91MP0000955_abnormal_spinal_cord0.81490226
92MP0000681_abnormal_thyroid_gland0.80246347
93MP0004484_altered_response_of0.79104928
94MP0003937_abnormal_limbs/digits/tail_de0.78611665
95MP0005595_abnormal_vascular_smooth0.78002726
96MP0003690_abnormal_glial_cell0.76525226
97MP0002177_abnormal_outer_ear0.76279987
98MP0002233_abnormal_nose_morphology0.76117144
99MP0008789_abnormal_olfactory_epithelium0.74911096
100MP0005620_abnormal_muscle_contractility0.74745089

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)5.41930919
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.41930919
3Focal motor seizures (HP:0011153)4.44201618
4Abnormal ciliary motility (HP:0012262)4.21209283
5Aplasia cutis congenita (HP:0001057)3.91622362
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.89652936
7Abnormal respiratory epithelium morphology (HP:0012253)3.82885871
8Abnormal respiratory motile cilium morphology (HP:0005938)3.82885871
9Abnormal respiratory motile cilium physiology (HP:0012261)3.38587255
10Tubulointerstitial nephritis (HP:0001970)3.35844324
11Septo-optic dysplasia (HP:0100842)3.34560801
12Febrile seizures (HP:0002373)3.23312899
13Epileptic encephalopathy (HP:0200134)3.21338120
14Hyperventilation (HP:0002883)3.11689127
15Atonic seizures (HP:0010819)3.00783715
16Nasolacrimal duct obstruction (HP:0000579)2.86009881
17Degeneration of the lateral corticospinal tracts (HP:0002314)2.80961810
18Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.80961810
19Parakeratosis (HP:0001036)2.76265391
20Retinal dysplasia (HP:0007973)2.66766459
21Muscle hypertrophy of the lower extremities (HP:0008968)2.64338585
22Congenital malformation of the right heart (HP:0011723)2.60651297
23Double outlet right ventricle (HP:0001719)2.60651297
24White forelock (HP:0002211)2.58320071
25Absent septum pellucidum (HP:0001331)2.53395786
26Upper limb muscle weakness (HP:0003484)2.46831539
27Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.43511203
28Nasal speech (HP:0001611)2.39612773
29Abnormality of the lacrimal duct (HP:0011481)2.31599888
30Lip pit (HP:0100267)2.30913970
31Morphological abnormality of the middle ear (HP:0008609)2.29840361
32Anomalous pulmonary venous return (HP:0010772)2.29321124
33Optic nerve hypoplasia (HP:0000609)2.28539269
34Gastroesophageal reflux (HP:0002020)2.27964022
35Hyperkalemia (HP:0002153)2.27258841
36Patchy hypopigmentation of hair (HP:0011365)2.26791014
37Supernumerary spleens (HP:0009799)2.26701720
38Calf muscle hypertrophy (HP:0008981)2.24250367
39Generalized tonic-clonic seizures (HP:0002069)2.21376314
40Sensory axonal neuropathy (HP:0003390)2.19458328
41Abnormality of the renal medulla (HP:0100957)2.18538761
42Duplication of thumb phalanx (HP:0009942)2.17934247
43Abnormality of the septum pellucidum (HP:0007375)2.17107407
44Duplicated collecting system (HP:0000081)2.17042727
45Bell-shaped thorax (HP:0001591)2.16687922
46Enlarged kidneys (HP:0000105)2.15329651
47Broad-based gait (HP:0002136)2.14845193
48Progressive cerebellar ataxia (HP:0002073)2.14580353
49Preauricular pit (HP:0004467)2.14349714
50Periauricular skin pits (HP:0100277)2.14349714
51Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.14037733
52Overfolded helix (HP:0000396)2.13695542
53Hypoplastic ischia (HP:0003175)2.12399103
54Abnormality of the nasolacrimal system (HP:0000614)2.12190859
55Methylmalonic acidemia (HP:0002912)2.09860463
56Decreased central vision (HP:0007663)2.09800689
57Rhinitis (HP:0012384)2.09282886
58Absent speech (HP:0001344)2.08268851
59Osteomalacia (HP:0002749)2.06542550
60Focal seizures (HP:0007359)2.06040045
61Anophthalmia (HP:0000528)2.05029267
62Humeroradial synostosis (HP:0003041)2.03695000
63Synostosis involving the elbow (HP:0003938)2.03695000
64Abnormality of the pulmonary veins (HP:0011718)1.99221175
65Aplasia involving bones of the extremities (HP:0009825)1.98890518
66Aplasia involving bones of the upper limbs (HP:0009823)1.98890518
67Aplasia of the phalanges of the hand (HP:0009802)1.98890518
68Gaze-evoked nystagmus (HP:0000640)1.97664347
69Fibular hypoplasia (HP:0003038)1.94237655
70Hypothermia (HP:0002045)1.94158568
71Decreased lacrimation (HP:0000633)1.92620757
72Abnormality of the calf musculature (HP:0001430)1.92233433
73Abnormality of the nasal septum (HP:0000419)1.91623725
74Hypoplastic left heart (HP:0004383)1.90972923
75Hypophosphatemic rickets (HP:0004912)1.90868860
76Nephronophthisis (HP:0000090)1.88497394
77Abnormality of the corticospinal tract (HP:0002492)1.88449350
78Congenital stationary night blindness (HP:0007642)1.87226048
79Abnormality of calcium-phosphate metabolism (HP:0100530)1.85427398
80Partial duplication of thumb phalanx (HP:0009944)1.83357832
81Medial flaring of the eyebrow (HP:0010747)1.82891671
82Thickened helices (HP:0000391)1.82175828
83Alacrima (HP:0000522)1.81926439
84Abnormality of incisor morphology (HP:0011063)1.81548009
85Abnormality of the renal collecting system (HP:0004742)1.80928909
86Abnormality of the ischium (HP:0003174)1.80015726
87Thyroid-stimulating hormone excess (HP:0002925)1.79047802
88Abnormality of the axillary hair (HP:0100134)1.76923705
89Abnormality of secondary sexual hair (HP:0009888)1.76923705
90Amblyopia (HP:0000646)1.76804993
91Abnormally folded helix (HP:0008544)1.75924899
92Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74389321
93Conical tooth (HP:0000698)1.73542252
94Absence seizures (HP:0002121)1.72695175
95Steppage gait (HP:0003376)1.72649211
96Short tibia (HP:0005736)1.72456634
97Chromosomal breakage induced by crosslinking agents (HP:0003221)1.72444033
98Dialeptic seizures (HP:0011146)1.72441753
99Hypoplastic heart (HP:0001961)1.71670483
100Metabolic alkalosis (HP:0200114)1.71549933

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK5.79666574
2CASK5.09416312
3TNIK3.47958986
4MKNK23.31494824
5INSRR2.64636890
6NTRK32.50644445
7EPHA42.18190308
8STK162.14420355
9PIK3CA1.84328310
10MKNK11.79827811
11MAP2K71.77695809
12STK391.74956975
13MUSK1.73079535
14PKN11.68795109
15GRK11.66078802
16OXSR11.64821265
17NEK61.55778619
18IRAK11.39882026
19NUAK11.27321576
20FGR1.26713686
21AKT31.25589781
22PHKG21.23620460
23PHKG11.23620460
24MAPK131.22540117
25PRPF4B1.22508218
26ADRBK21.21608578
27GRK71.17386032
28PNCK1.17176055
29MAP3K41.16939710
30OBSCN1.13964334
31FES1.08364065
32MARK11.07572716
33PLK21.04637764
34NME11.03426993
35PRKCE1.03180700
36BMPR21.00814168
37MAP3K131.00414728
38NTRK21.00133594
39DMPK0.99112535
40CDK30.95750250
41MAPK150.94524837
42CAMK2A0.93419958
43DYRK1A0.88135863
44YES10.87867839
45BMPR1B0.84656820
46CAMK2B0.82876674
47EIF2AK20.81897388
48PAK60.79489602
49ROCK20.79342004
50BCR0.75128645
51PBK0.74543883
52CDC42BPA0.70122073
53EPHB10.69725529
54PRKAA20.69420823
55CAMK2D0.68561942
56FER0.67291410
57PRKG10.65711749
58CAMK1G0.65388960
59RIPK40.64704093
60PRKCG0.63136448
61SGK10.62733558
62TNK20.62482701
63CDK190.61954446
64SGK2230.60503622
65SGK4940.60503622
66GRK50.60021878
67MST40.59835932
68PRKCQ0.59498626
69PRKACA0.59091824
70CSNK1G20.57520293
71CAMK10.56819217
72PTK2B0.55956885
73MAPKAPK50.55798932
74WNK10.53493231
75WNK40.53137830
76PAK30.51985345
77UHMK10.51172955
78CDK50.51018420
79ROCK10.49577755
80IRAK30.46839606
81ERBB40.46751074
82CSNK1A1L0.46728116
83MYLK0.44892255
84CAMK2G0.44411670
85MAPK120.43197991
86TRPM70.43030542
87CLK10.42997635
88MAP3K140.42875373
89SGK20.42516895
90DYRK20.42211004
91ADRBK10.41875497
92MARK20.40388462
93TIE10.40215576
94PRKD10.40095099
95STK240.38360302
96DAPK20.38195545
97FYN0.36836825
98NTRK10.36085636
99MAPK70.35555897
100PRKACB0.35048176

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.02086790
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.69650667
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.59374157
4Morphine addiction_Homo sapiens_hsa050322.40159248
5Taste transduction_Homo sapiens_hsa047422.38049695
6Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.34102896
7Serotonergic synapse_Homo sapiens_hsa047262.32219982
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.30896755
9Glutamatergic synapse_Homo sapiens_hsa047242.24969777
10GABAergic synapse_Homo sapiens_hsa047272.24140460
11Phototransduction_Homo sapiens_hsa047442.16357412
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.00666207
13Circadian entrainment_Homo sapiens_hsa047131.96497698
14Collecting duct acid secretion_Homo sapiens_hsa049661.82748571
15Calcium signaling pathway_Homo sapiens_hsa040201.81552329
16Salivary secretion_Homo sapiens_hsa049701.78618135
17Oxidative phosphorylation_Homo sapiens_hsa001901.75776193
18Fatty acid elongation_Homo sapiens_hsa000621.71597486
19Axon guidance_Homo sapiens_hsa043601.69206108
20Long-term depression_Homo sapiens_hsa047301.68764679
21Cardiac muscle contraction_Homo sapiens_hsa042601.65308292
22Renin secretion_Homo sapiens_hsa049241.61738569
23Olfactory transduction_Homo sapiens_hsa047401.61116899
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.58463608
25Synaptic vesicle cycle_Homo sapiens_hsa047211.55790215
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.48540559
27Steroid biosynthesis_Homo sapiens_hsa001001.47309115
28Oxytocin signaling pathway_Homo sapiens_hsa049211.46625999
29Amphetamine addiction_Homo sapiens_hsa050311.45855600
30Insulin secretion_Homo sapiens_hsa049111.45712091
31Dilated cardiomyopathy_Homo sapiens_hsa054141.38515860
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.35845658
33Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.33845579
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.32986236
35Dopaminergic synapse_Homo sapiens_hsa047281.31600208
36Gastric acid secretion_Homo sapiens_hsa049711.31274785
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.28817787
38Sphingolipid metabolism_Homo sapiens_hsa006001.27911857
39Vascular smooth muscle contraction_Homo sapiens_hsa042701.25759058
40Ether lipid metabolism_Homo sapiens_hsa005651.23386149
41Cholinergic synapse_Homo sapiens_hsa047251.20211783
42Alzheimers disease_Homo sapiens_hsa050101.17218784
43cAMP signaling pathway_Homo sapiens_hsa040241.13877989
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11244005
45Long-term potentiation_Homo sapiens_hsa047201.10722799
46Cocaine addiction_Homo sapiens_hsa050301.10345782
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.07341406
48Rheumatoid arthritis_Homo sapiens_hsa053231.03815455
49Autoimmune thyroid disease_Homo sapiens_hsa053201.01099631
50Parkinsons disease_Homo sapiens_hsa050120.96527234
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90632074
52Arachidonic acid metabolism_Homo sapiens_hsa005900.89175406
53Type II diabetes mellitus_Homo sapiens_hsa049300.83667835
54Vibrio cholerae infection_Homo sapiens_hsa051100.80884308
55Aldosterone synthesis and secretion_Homo sapiens_hsa049250.80727700
56Pancreatic secretion_Homo sapiens_hsa049720.79387083
57Ovarian steroidogenesis_Homo sapiens_hsa049130.78551703
58* Ras signaling pathway_Homo sapiens_hsa040140.78416145
59Arginine and proline metabolism_Homo sapiens_hsa003300.75365551
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74454083
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69162646
62Butanoate metabolism_Homo sapiens_hsa006500.67077359
63Histidine metabolism_Homo sapiens_hsa003400.66781758
64Linoleic acid metabolism_Homo sapiens_hsa005910.63156185
65Wnt signaling pathway_Homo sapiens_hsa043100.62465028
66Huntingtons disease_Homo sapiens_hsa050160.61990487
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61778913
68ErbB signaling pathway_Homo sapiens_hsa040120.61591308
69Phagosome_Homo sapiens_hsa041450.59047181
70* MAPK signaling pathway_Homo sapiens_hsa040100.58815142
71Gap junction_Homo sapiens_hsa045400.56876025
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54214033
73GnRH signaling pathway_Homo sapiens_hsa049120.52557594
74* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52035159
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50435909
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50393586
77Inositol phosphate metabolism_Homo sapiens_hsa005620.50259414
78Melanogenesis_Homo sapiens_hsa049160.49677910
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46026965
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44599643
81* Melanoma_Homo sapiens_hsa052180.44496093
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44080719
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43549398
84Fatty acid biosynthesis_Homo sapiens_hsa000610.43294376
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.42887416
86Choline metabolism in cancer_Homo sapiens_hsa052310.42082906
87Mineral absorption_Homo sapiens_hsa049780.41802679
88* Rap1 signaling pathway_Homo sapiens_hsa040150.41301074
89ECM-receptor interaction_Homo sapiens_hsa045120.40819963
90Circadian rhythm_Homo sapiens_hsa047100.40315447
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39818804
92Fanconi anemia pathway_Homo sapiens_hsa034600.38672774
93Dorso-ventral axis formation_Homo sapiens_hsa043200.37635242
94Retinol metabolism_Homo sapiens_hsa008300.34575829
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30936536
96Non-homologous end-joining_Homo sapiens_hsa034500.27817711
97Basal cell carcinoma_Homo sapiens_hsa052170.26399016
98African trypanosomiasis_Homo sapiens_hsa051430.25100142
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.23121313
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.21021612

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