FGF8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* cell migration involved in gastrulation (GO:0042074)8.40674807
2regulation of mesoderm development (GO:2000380)8.24177262
3nodal signaling pathway (GO:0038092)6.47325698
4* signal transduction involved in regulation of gene expression (GO:0023019)5.81572618
5primitive streak formation (GO:0090009)5.53054567
6behavioral response to nicotine (GO:0035095)5.42074685
7sulfation (GO:0051923)5.16904726
8mitotic metaphase plate congression (GO:0007080)4.85363468
9DNA unwinding involved in DNA replication (GO:0006268)4.69184539
10secondary heart field specification (GO:0003139)4.63204617
11heart field specification (GO:0003128)4.63204617
12regulation of posttranscriptional gene silencing (GO:0060147)4.61371773
13regulation of gene silencing by miRNA (GO:0060964)4.61371773
14regulation of gene silencing by RNA (GO:0060966)4.61371773
15establishment of integrated proviral latency (GO:0075713)4.50684289
16folic acid-containing compound biosynthetic process (GO:0009396)4.40942983
17ribosomal small subunit assembly (GO:0000028)4.39415907
18regulation of glomerulus development (GO:0090192)4.30358600
19paraxial mesoderm development (GO:0048339)4.30331841
20water-soluble vitamin biosynthetic process (GO:0042364)4.30179235
21negative regulation of androgen receptor signaling pathway (GO:0060766)4.29393493
22negative regulation of appetite (GO:0032099)4.26410773
23negative regulation of response to food (GO:0032096)4.26410773
24mitochondrial respiratory chain complex I assembly (GO:0032981)4.25119261
25NADH dehydrogenase complex assembly (GO:0010257)4.25119261
26mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.25119261
27protein localization to kinetochore (GO:0034501)4.22705703
28protein complex localization (GO:0031503)4.22192562
29negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.21742492
30protein polyglutamylation (GO:0018095)4.20964184
31anterior/posterior axis specification, embryo (GO:0008595)4.18806303
32outer ear morphogenesis (GO:0042473)4.16878855
33metaphase plate congression (GO:0051310)4.13180559
34regulation of Wnt signaling pathway involved in heart development (GO:0003307)4.04976893
35negative regulation of systemic arterial blood pressure (GO:0003085)4.00991851
36somite development (GO:0061053)3.94446832
37ribosome assembly (GO:0042255)3.87882284
38chaperone-mediated protein transport (GO:0072321)3.87655840
39vitamin catabolic process (GO:0009111)3.87146011
40fat-soluble vitamin catabolic process (GO:0042363)3.87146011
41regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.84504625
42negative regulation of transcription regulatory region DNA binding (GO:2000678)3.79891094
43pre-miRNA processing (GO:0031054)3.79809097
44positive regulation of fatty acid oxidation (GO:0046321)3.74774625
45* cell proliferation in forebrain (GO:0021846)3.73803762
46establishment of chromosome localization (GO:0051303)3.72861273
47positive regulation of cAMP-mediated signaling (GO:0043950)3.72785125
48DNA strand elongation involved in DNA replication (GO:0006271)3.68609803
49DNA replication initiation (GO:0006270)3.68203859
50mitotic sister chromatid segregation (GO:0000070)3.66994907
51single strand break repair (GO:0000012)3.64050667
52mitotic nuclear envelope disassembly (GO:0007077)3.63855144
53protein complex biogenesis (GO:0070271)3.62570938
54* gastrulation (GO:0007369)3.59531243
55regulation of cell proliferation involved in kidney development (GO:1901722)3.56768735
56negative regulation of cell fate specification (GO:0009996)3.56468842
57head development (GO:0060322)3.52906302
58DNA strand elongation (GO:0022616)3.49775324
59tooth mineralization (GO:0034505)3.47932936
60protein localization to chromosome, centromeric region (GO:0071459)3.47036204
61somite rostral/caudal axis specification (GO:0032525)3.46775819
62SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.45290992
63positive regulation of SMAD protein import into nucleus (GO:0060391)3.43770791
64spliceosomal snRNP assembly (GO:0000387)3.43596552
65cellular response to ATP (GO:0071318)3.41794914
66cotranslational protein targeting to membrane (GO:0006613)3.39485064
67regulation of collateral sprouting (GO:0048670)3.38981048
68membrane disassembly (GO:0030397)3.35763671
69nuclear envelope disassembly (GO:0051081)3.35763671
70viral life cycle (GO:0019058)3.34270310
71anterior/posterior axis specification (GO:0009948)3.33101522
72protein targeting to ER (GO:0045047)3.32816235
73mitochondrial respiratory chain complex assembly (GO:0033108)3.31825089
74cornea development in camera-type eye (GO:0061303)3.31648080
75pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.31311080
76maturation of SSU-rRNA (GO:0030490)3.28689005
77SMAD protein signal transduction (GO:0060395)3.26819662
78establishment of viral latency (GO:0019043)3.24086589
79positive regulation of cardiac muscle cell differentiation (GO:2000727)3.23834519
80cellular protein complex disassembly (GO:0043624)3.22324709
81positive regulation of fatty acid beta-oxidation (GO:0032000)3.21816979
82CENP-A containing nucleosome assembly (GO:0034080)3.21722595
83specification of organ identity (GO:0010092)3.21154992
84DNA replication-dependent nucleosome organization (GO:0034723)3.19970667
85DNA replication-dependent nucleosome assembly (GO:0006335)3.19970667
86negative regulation of chromosome segregation (GO:0051985)3.19268207
87negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.18851007
88nephron tubule formation (GO:0072079)3.17623417
89negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.17591808
90negative regulation of sister chromatid segregation (GO:0033046)3.17591808
91negative regulation of mitotic sister chromatid separation (GO:2000816)3.17591808
92negative regulation of mitotic sister chromatid segregation (GO:0033048)3.17591808
93spindle checkpoint (GO:0031577)3.17223863
94lymphangiogenesis (GO:0001946)3.17097582
95regulation of DNA endoreduplication (GO:0032875)3.15950582
96nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.15939425
97spliceosomal complex assembly (GO:0000245)3.14928245
98post-anal tail morphogenesis (GO:0036342)3.12727871
99establishment of protein localization to endoplasmic reticulum (GO:0072599)3.12380710
100regulation of sequestering of triglyceride (GO:0010889)3.12041402
101protein localization to endoplasmic reticulum (GO:0070972)3.11880141
102chromatin remodeling at centromere (GO:0031055)3.11523851
103regulation of gastrulation (GO:0010470)3.10477212
104mitotic chromosome condensation (GO:0007076)3.10153261
105sister chromatid segregation (GO:0000819)3.09188649
106nucleobase biosynthetic process (GO:0046112)3.07701567
107ribosomal large subunit biogenesis (GO:0042273)3.07621719
108viral transcription (GO:0019083)3.04122320
109mitotic spindle assembly checkpoint (GO:0007094)3.03844540
110membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.02974062
111attachment of spindle microtubules to kinetochore (GO:0008608)3.02583730
112dentate gyrus development (GO:0021542)3.01988161
113regulation of spindle organization (GO:0090224)3.01613196
114parturition (GO:0007567)3.00378370
115spindle assembly checkpoint (GO:0071173)3.00153286
116anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.99785711
117transmission of nerve impulse (GO:0019226)2.99471874
118limb bud formation (GO:0060174)2.96496062
119regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.95082196
120translational termination (GO:0006415)2.94273514
121mitotic spindle checkpoint (GO:0071174)2.93805709
122proteasome assembly (GO:0043248)2.93150955
123formation of translation preinitiation complex (GO:0001731)2.92971095
124kinetochore organization (GO:0051383)2.91924707
125DNA replication checkpoint (GO:0000076)2.91624833
126DNA replication-independent nucleosome assembly (GO:0006336)2.90892621
127DNA replication-independent nucleosome organization (GO:0034724)2.90892621
128positive regulation of potassium ion transmembrane transport (GO:1901381)2.90351626
129telomere maintenance via semi-conservative replication (GO:0032201)2.89894487
130deoxyribonucleotide biosynthetic process (GO:0009263)2.89683279
131nuclear pore organization (GO:0006999)2.89500808
132translational initiation (GO:0006413)2.89036169
133establishment of protein localization to mitochondrial membrane (GO:0090151)2.88971002
134* morphogenesis of embryonic epithelium (GO:0016331)2.88767742
135negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.88571574
136kinetochore assembly (GO:0051382)2.87885956
137regulation of chromosome segregation (GO:0051983)2.87445334
138regulation of centrosome cycle (GO:0046605)2.87370458
139base-excision repair, AP site formation (GO:0006285)2.86437804
140translational elongation (GO:0006414)2.86434438
141regulation of stem cell maintenance (GO:2000036)2.86350944
142IMP biosynthetic process (GO:0006188)2.85925497
143pituitary gland development (GO:0021983)2.85588194
144positive regulation of chromosome segregation (GO:0051984)2.85175473
145regulation of action potential (GO:0098900)2.85107031
146ribonucleoprotein complex biogenesis (GO:0022613)2.85066713
147ribosome biogenesis (GO:0042254)2.85065172
148DNA deamination (GO:0045006)2.84929698
149ribosomal small subunit biogenesis (GO:0042274)2.84412253
150regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.83582102
151response to UV-C (GO:0010225)2.81192081
152negative regulation of mast cell activation (GO:0033004)2.75986524
153regulation of appetite (GO:0032098)2.74991157
154dorsal/ventral axis specification (GO:0009950)2.74221371
155male meiosis I (GO:0007141)2.72666299
156cellular anion homeostasis (GO:0030002)2.72290686
157piRNA metabolic process (GO:0034587)2.69987305
158purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.69673402
1593-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.69673402
160* pharyngeal system development (GO:0060037)2.69184546
161regulation of cardioblast proliferation (GO:0003264)2.67498247
162regulation of secondary heart field cardioblast proliferation (GO:0003266)2.67498247
163indolalkylamine metabolic process (GO:0006586)2.66529576
164tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.65822704
165RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.65822704
166regulation of transcription regulatory region DNA binding (GO:2000677)2.65731545
167negative regulation of heart growth (GO:0061117)2.65232146
168negative regulation of cardiac muscle tissue growth (GO:0055022)2.65232146
169regulation of response to food (GO:0032095)2.62872325
170endoderm formation (GO:0001706)2.61723590
171gamma-aminobutyric acid transport (GO:0015812)2.60414397
172axoneme assembly (GO:0035082)2.60245169
173negative regulation of gene silencing (GO:0060969)2.57314595
174regulation of chromatin binding (GO:0035561)2.56687091
175protein complex disassembly (GO:0043241)2.56244180
176GPI anchor metabolic process (GO:0006505)2.54963862
177middle ear morphogenesis (GO:0042474)2.54128073
178cartilage morphogenesis (GO:0060536)2.53700891
179energy coupled proton transport, down electrochemical gradient (GO:0015985)2.51913272
180ATP synthesis coupled proton transport (GO:0015986)2.51913272
181exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.50911094
182primary amino compound metabolic process (GO:1901160)2.50598238
183muscle cell fate commitment (GO:0042693)2.49103180
184regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.48988718
185regulation of female receptivity (GO:0045924)2.44420812
186regulation of activation of Janus kinase activity (GO:0010533)2.43903310
187nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.43580591
188macromolecular complex disassembly (GO:0032984)2.42670740
189magnesium ion transport (GO:0015693)2.42474291

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.85456619
2EZH2_22144423_ChIP-Seq_EOC_Human5.46212904
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.45382666
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.80368293
5FOXM1_23109430_ChIP-Seq_U2OS_Human4.77765370
6STAT6_21828071_ChIP-Seq_BEAS2B_Human3.65471338
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.64395059
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.54922413
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.52137615
10MYC_19079543_ChIP-ChIP_MESCs_Mouse3.40909155
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.27090908
12EST1_17652178_ChIP-ChIP_JURKAT_Human3.04572646
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.02341102
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.97942803
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.89633955
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.79829439
17BMI1_23680149_ChIP-Seq_NPCS_Mouse2.77702568
18* EED_16625203_ChIP-ChIP_MESCs_Mouse2.71388792
19XRN2_22483619_ChIP-Seq_HELA_Human2.68336846
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.64467873
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.62895674
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.55339128
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.52442040
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.46798113
25GBX2_23144817_ChIP-Seq_PC3_Human2.41363845
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.38939221
27* EZH2_27304074_Chip-Seq_ESCs_Mouse2.32351375
28* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.32189306
29* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.29064021
30POU5F1_16153702_ChIP-ChIP_HESCs_Human2.25553913
31FUS_26573619_Chip-Seq_HEK293_Human2.24500540
32TP63_19390658_ChIP-ChIP_HaCaT_Human2.22252191
33IRF1_19129219_ChIP-ChIP_H3396_Human2.21210152
34POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.20700160
35ZNF274_21170338_ChIP-Seq_K562_Hela2.18914914
36ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.18013679
37* CBX2_27304074_Chip-Seq_ESCs_Mouse2.16922827
38KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.14072306
39KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.14072306
40KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.14072306
41E2F1_18555785_ChIP-Seq_MESCs_Mouse2.10670895
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.09551756
43AR_21909140_ChIP-Seq_LNCAP_Human2.08063752
44TTF2_22483619_ChIP-Seq_HELA_Human2.06502744
45MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.05601610
46VDR_22108803_ChIP-Seq_LS180_Human2.03931640
47* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.01909114
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.99355809
49IGF1R_20145208_ChIP-Seq_DFB_Human1.97768340
50TP63_17297297_ChIP-ChIP_HaCaT_Human1.97312759
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.96706081
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.93123793
53POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.93032828
54TCF3_18692474_ChIP-Seq_MEFs_Mouse1.92966235
55* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.92329219
56* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.92016220
57* EWS_26573619_Chip-Seq_HEK293_Human1.88849378
58MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87428935
59MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.85190181
60RNF2_27304074_Chip-Seq_NSC_Mouse1.84546798
61BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.80228366
62* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.76178277
63* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.76178277
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.75009095
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.74267777
66VDR_23849224_ChIP-Seq_CD4+_Human1.70959431
67* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.70933655
68ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.70052719
69ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68984506
70DCP1A_22483619_ChIP-Seq_HELA_Human1.68668236
71GABP_19822575_ChIP-Seq_HepG2_Human1.65683958
72HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.63448531
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.63167510
74* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.63121385
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60555119
76NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.59630010
77RNF2_27304074_Chip-Seq_ESCs_Mouse1.59255793
78* EZH2_27294783_Chip-Seq_ESCs_Mouse1.58812942
79* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.58314430
80* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.58221824
81RBPJ_22232070_ChIP-Seq_NCS_Mouse1.56974179
82TDRD3_21172665_ChIP-Seq_MCF-7_Human1.55352934
83* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.54621013
84CIITA_25753668_ChIP-Seq_RAJI_Human1.53995392
85E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.51791698
86MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50316742
87CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.49878894
88* TP53_20018659_ChIP-ChIP_R1E_Mouse1.49849932
89TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49006961
90* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.47913406
91YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47617764
92KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.47337995
93POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.47244680
94FOXP3_21729870_ChIP-Seq_TREG_Human1.46073876
95* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.43703786
96ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43118969
97CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42053668
98NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39812137
99* MYC_18940864_ChIP-ChIP_HL60_Human1.39339452
100EGR1_19374776_ChIP-ChIP_THP-1_Human1.39221731
101CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.39185080
102P300_19829295_ChIP-Seq_ESCs_Human1.39039383
103GATA1_26923725_Chip-Seq_HPCs_Mouse1.37675864
104CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37594201
105* RING1B_27294783_Chip-Seq_ESCs_Mouse1.37085275
106SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.37033770
107TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.36542183
108SRY_22984422_ChIP-ChIP_TESTIS_Rat1.35140842
109EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34194260
110AUTS2_25519132_ChIP-Seq_293T-REX_Human1.32704023
111SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.31533450
112ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31094190
113* NANOG_16153702_ChIP-ChIP_HESCs_Human1.30407289
114PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28007342
115KDM5A_27292631_Chip-Seq_BREAST_Human1.27751147
116TCF3_18692474_ChIP-Seq_MESCs_Mouse1.26520161
117* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.25191230
118TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.24687569
119SOX2_18555785_ChIP-Seq_MESCs_Mouse1.23287698
120UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23223428
121ER_23166858_ChIP-Seq_MCF-7_Human1.22504521
122MYC_22102868_ChIP-Seq_BL_Human1.21215311
123OCT4_18692474_ChIP-Seq_MEFs_Mouse1.18464726
124KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.17812555
125YY1_21170310_ChIP-Seq_MESCs_Mouse1.17228003
126REST_21632747_ChIP-Seq_MESCs_Mouse1.16886257
127ELK1_19687146_ChIP-ChIP_HELA_Human1.15642440
128CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.15336065
129CBP_20019798_ChIP-Seq_JUKART_Human1.14814067
130IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14814067
131FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.14775921
132DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14442853
133TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13585261
134P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13061114
135CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.12957875
136NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.09624886
137POU5F1_16518401_ChIP-PET_MESCs_Mouse1.09010179
138KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07928662
139GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07307543
140* NCOR_22424771_ChIP-Seq_293T_Human1.07256852
141HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06871711
142* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06713052
143E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06170735
144SOX2_16153702_ChIP-ChIP_HESCs_Human1.05683134
145SOX2_18692474_ChIP-Seq_MEFs_Mouse1.03745527
146* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.01265771
147NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.99347668
148GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98594364
149DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98453804
150FOXA1_25329375_ChIP-Seq_VCAP_Human0.98290725
151FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98290725
152ELF1_17652178_ChIP-ChIP_JURKAT_Human0.98262999
153SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.98028266
154BCAT_22108803_ChIP-Seq_LS180_Human0.97877902
155ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.95541462
156SRF_21415370_ChIP-Seq_HL-1_Mouse0.95049371
157FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94789588
158TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.93808923
159NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93646751
160MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93577550
161PRDM14_20953172_ChIP-Seq_ESCs_Human0.93531344
162* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93292395
163POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92220621
164* NANOG_21062744_ChIP-ChIP_HESCs_Human0.91671599
165TAF15_26573619_Chip-Seq_HEK293_Human0.90793998
166ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90625416
167SMAD4_21799915_ChIP-Seq_A2780_Human0.90299071
168TFEB_21752829_ChIP-Seq_HELA_Human0.89822475
169CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.89658216
170* SMAD3_21741376_ChIP-Seq_EPCs_Human0.88333277
171NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.87995602
172PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.87716097
173ZFP281_18757296_ChIP-ChIP_E14_Mouse0.87060169
174POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.86710545
175STAT3_1855785_ChIP-Seq_MESCs_Mouse0.86453408
176FLI1_21867929_ChIP-Seq_TH2_Mouse0.86002417
177* SMAD4_21741376_ChIP-Seq_EPCs_Human0.85348358
178AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83931988
179SALL1_21062744_ChIP-ChIP_HESCs_Human0.83629737
180PADI4_21655091_ChIP-ChIP_MCF-7_Human0.83601401
181KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.83490757
182KDM2B_26808549_Chip-Seq_REH_Human0.83485846
183TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.81574512
184TAL1_26923725_Chip-Seq_HPCs_Mouse0.80916013

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003890_abnormal_embryonic-extraembry5.50485328
2MP0004133_heterotaxia5.02532738
3MP0003693_abnormal_embryo_hatching4.14217408
4MP0004957_abnormal_blastocyst_morpholog3.86708941
5MP0003119_abnormal_digestive_system3.68581643
6MP0002234_abnormal_pharynx_morphology3.61919756
7MP0010030_abnormal_orbit_morphology3.41891328
8MP0009379_abnormal_foot_pigmentation3.31976490
9MP0003111_abnormal_nucleus_morphology3.25211922
10* MP0003077_abnormal_cell_cycle3.21630636
11MP0010094_abnormal_chromosome_stability3.04562998
12* MP0008932_abnormal_embryonic_tissue2.86452791
13MP0008877_abnormal_DNA_methylation2.70550663
14MP0002837_dystrophic_cardiac_calcinosis2.69734247
15MP0002138_abnormal_hepatobiliary_system2.65237390
16MP0002254_reproductive_system_inflammat2.63553151
17MP0001730_embryonic_growth_arrest2.60457543
18MP0005646_abnormal_pituitary_gland2.55768196
19MP0006292_abnormal_olfactory_placode2.42952555
20MP0003123_paternal_imprinting2.27281095
21MP0008007_abnormal_cellular_replicative2.19510950
22MP0002653_abnormal_ependyma_morphology2.15585594
23MP0000631_abnormal_neuroendocrine_gland2.14315237
24* MP0002084_abnormal_developmental_patter2.13628462
25MP0004885_abnormal_endolymph2.12159996
26MP0001672_abnormal_embryogenesis/_devel2.10584177
27MP0005380_embryogenesis_phenotype2.10584177
28MP0002111_abnormal_tail_morphology2.10145034
29MP0009250_abnormal_appendicular_skeleto2.01079135
30MP0003718_maternal_effect1.99574989
31MP0003315_abnormal_perineum_morphology1.98387993
32* MP0003937_abnormal_limbs/digits/tail_de1.97082624
33* MP0002085_abnormal_embryonic_tissue1.93678199
34MP0004134_abnormal_chest_morphology1.90330778
35MP0008058_abnormal_DNA_repair1.83470268
36* MP0001697_abnormal_embryo_size1.80180044
37MP0008057_abnormal_DNA_replication1.76191403
38* MP0000350_abnormal_cell_proliferation1.73070853
39MP0009053_abnormal_anal_canal1.69662869
40MP0004145_abnormal_muscle_electrophysio1.68373682
41MP0002163_abnormal_gland_morphology1.59810633
42MP0005551_abnormal_eye_electrophysiolog1.56147191
43MP0004130_abnormal_muscle_cell1.55363621
44MP0003984_embryonic_growth_retardation1.50754285
45MP0002088_abnormal_embryonic_growth/wei1.48056570
46MP0003567_abnormal_fetal_cardiomyocyte1.46746329
47MP0003880_abnormal_central_pattern1.45681806
48MP0003385_abnormal_body_wall1.44899834
49* MP0002080_prenatal_lethality1.43131238
50MP0000462_abnormal_digestive_system1.42158487
51MP0000537_abnormal_urethra_morphology1.41065227
52MP0004142_abnormal_muscle_tone1.40802641
53MP0008872_abnormal_physiological_respon1.38171664
54MP0002249_abnormal_larynx_morphology1.37422784
55MP0005394_taste/olfaction_phenotype1.35766011
56MP0005499_abnormal_olfactory_system1.35766011
57MP0001529_abnormal_vocalization1.33711858
58MP0001968_abnormal_touch/_nociception1.33313858
59MP0001293_anophthalmia1.32917683
60MP0002876_abnormal_thyroid_physiology1.32852055
61MP0008789_abnormal_olfactory_epithelium1.32811409
62MP0002932_abnormal_joint_morphology1.31118301
63MP0009384_cardiac_valve_regurgitation1.30419620
64MP0002272_abnormal_nervous_system1.29863387
65* MP0002086_abnormal_extraembryonic_tissu1.25959855
66MP0003283_abnormal_digestive_organ1.25867176
67MP0005083_abnormal_biliary_tract1.24295164
68MP0001919_abnormal_reproductive_system1.22864748
69MP0003806_abnormal_nucleotide_metabolis1.22260574
70* MP0003861_abnormal_nervous_system1.20467072
71MP0000613_abnormal_salivary_gland1.19758283
72* MP0000428_abnormal_craniofacial_morphol1.19172746
73* MP0003935_abnormal_craniofacial_develop1.17651187
74MP0002102_abnormal_ear_morphology1.16961084
75MP0002332_abnormal_exercise_endurance1.16616365
76MP0002277_abnormal_respiratory_mucosa1.16182867
77MP0003136_yellow_coat_color1.15749114
78MP0005084_abnormal_gallbladder_morpholo1.14952692
79MP0002282_abnormal_trachea_morphology1.13967141
80* MP0000432_abnormal_head_morphology1.12862221
81MP0003011_delayed_dark_adaptation1.12237971
82MP0009672_abnormal_birth_weight1.11132351
83MP0003195_calcinosis1.10975491
84MP0002938_white_spotting1.09739349
85MP0003121_genomic_imprinting1.07701668
86MP0002735_abnormal_chemical_nociception1.07583821
87MP0010352_gastrointestinal_tract_polyps1.06873740
88MP0002822_catalepsy1.06129080
89* MP0003942_abnormal_urinary_system1.05029768
90MP0001286_abnormal_eye_development1.04268728
91MP0000566_synostosis1.04264194
92MP0001542_abnormal_bone_strength1.03288685
93MP0000681_abnormal_thyroid_gland1.03283631
94MP0009745_abnormal_behavioral_response1.01833801
95MP0005195_abnormal_posterior_eye1.01806912
96MP0002736_abnormal_nociception_after1.00842277
97MP0008995_early_reproductive_senescence1.00518617
98* MP0004197_abnormal_fetal_growth/weight/0.99759638
99MP0002928_abnormal_bile_duct0.98801510
100* MP0000026_abnormal_inner_ear0.97341934
101MP0003941_abnormal_skin_development0.96732543
102MP0001440_abnormal_grooming_behavior0.96226558
103MP0003878_abnormal_ear_physiology0.95861342
104MP0005377_hearing/vestibular/ear_phenot0.95861342
105* MP0000678_abnormal_parathyroid_gland0.95791952
106MP0003122_maternal_imprinting0.94821330
107MP0001188_hyperpigmentation0.93438751
108MP0002734_abnormal_mechanical_nocicepti0.93315416
109* MP0000049_abnormal_middle_ear0.93216899
110MP0002184_abnormal_innervation0.92809966
111MP0005379_endocrine/exocrine_gland_phen0.91202855
112* MP0001963_abnormal_hearing_physiology0.91117862
113MP0002098_abnormal_vibrissa_morphology0.91072807
114MP0005423_abnormal_somatic_nervous0.90430308
115MP0000778_abnormal_nervous_system0.90396525
116MP0003566_abnormal_cell_adhesion0.90041847
117MP0002733_abnormal_thermal_nociception0.89971870
118MP0002233_abnormal_nose_morphology0.89768434
119* MP0000313_abnormal_cell_death0.87307702
120MP0003755_abnormal_palate_morphology0.87178662
121* MP0002752_abnormal_somatic_nervous0.87116555
122MP0001486_abnormal_startle_reflex0.86938625
123MP0001727_abnormal_embryo_implantation0.86673766
124MP0002139_abnormal_hepatobiliary_system0.85693990
125MP0002114_abnormal_axial_skeleton0.85245052
126MP0005670_abnormal_white_adipose0.84529535
127MP0001119_abnormal_female_reproductive0.84264163
128* MP0002925_abnormal_cardiovascular_devel0.82543394
129MP0002210_abnormal_sex_determination0.82533884
130MP0006276_abnormal_autonomic_nervous0.81555208
131MP0003638_abnormal_response/metabolism_0.80514965
132MP0003646_muscle_fatigue0.80354256
133MP0005253_abnormal_eye_physiology0.80234734
134MP0001348_abnormal_lacrimal_gland0.78699653
135MP0006072_abnormal_retinal_apoptosis0.78595551
136* MP0002116_abnormal_craniofacial_bone0.77847772
137MP0000534_abnormal_ureter_morphology0.77050020
138MP0002751_abnormal_autonomic_nervous0.75510676
139MP0003635_abnormal_synaptic_transmissio0.74255357
140MP0001915_intracranial_hemorrhage0.74207485
141MP0005410_abnormal_fertilization0.73052867
142MP0003787_abnormal_imprinting0.72975964
143MP0003936_abnormal_reproductive_system0.72536746
144MP0005174_abnormal_tail_pigmentation0.71582429
145MP0009765_abnormal_xenobiotic_induced0.71148801
146MP0002019_abnormal_tumor_incidence0.70558121
147MP0000653_abnormal_sex_gland0.69174958
148MP0001145_abnormal_male_reproductive0.67931776
149MP0001849_ear_inflammation0.67035984
150MP0003786_premature_aging0.66768823
151MP0003938_abnormal_ear_development0.66691944
152* MP0000266_abnormal_heart_morphology0.64427731
153* MP0002160_abnormal_reproductive_system0.62796204
154MP0001929_abnormal_gametogenesis0.60249803
155MP0005384_cellular_phenotype0.59319550
156* MP0002177_abnormal_outer_ear0.58512114
157MP0005266_abnormal_metabolism0.57186095
158MP0005076_abnormal_cell_differentiation0.56958617
159MP0003699_abnormal_female_reproductive0.56787808
160MP0002092_abnormal_eye_morphology0.56763259
161MP0010307_abnormal_tumor_latency0.56113737
162MP0000470_abnormal_stomach_morphology0.56105448
163MP0000750_abnormal_muscle_regeneration0.56081879
164* MP0005389_reproductive_system_phenotype0.54507190
165MP0001485_abnormal_pinna_reflex0.54161663

Predicted human phenotypes

RankGene SetZ-score
1Abdominal situs inversus (HP:0003363)7.18427512
2Abnormality of abdominal situs (HP:0011620)7.18427512
3Pendular nystagmus (HP:0012043)4.84766803
4Absent rod-and cone-mediated responses on ERG (HP:0007688)4.53992712
5Rib fusion (HP:0000902)4.29925298
6Supernumerary spleens (HP:0009799)4.00257217
7True hermaphroditism (HP:0010459)3.86982600
8Birth length less than 3rd percentile (HP:0003561)3.76957125
9Colon cancer (HP:0003003)3.70395003
10Abnormal lung lobation (HP:0002101)3.59099835
11Pancreatic fibrosis (HP:0100732)3.57101836
12Absent radius (HP:0003974)3.54817475
13Pancreatic cysts (HP:0001737)3.53263017
14Asplenia (HP:0001746)3.42796228
15Aplasia involving forearm bones (HP:0009822)3.37945260
16Absent forearm bone (HP:0003953)3.37945260
17Abnormal rod and cone electroretinograms (HP:0008323)3.31820538
18Abolished electroretinogram (ERG) (HP:0000550)3.27695550
19Shawl scrotum (HP:0000049)3.22236194
20Breast hypoplasia (HP:0003187)3.22039118
21Abnormality of the phalanges of the 2nd finger (HP:0009541)3.20050939
22Morphological abnormality of the middle ear (HP:0008609)3.18787210
23Severe visual impairment (HP:0001141)3.17165587
24Reticulocytopenia (HP:0001896)3.16015740
25Carpal bone hypoplasia (HP:0001498)3.13625604
26Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.12933579
27Short 1st metacarpal (HP:0010034)3.12933579
28Aplasia/hypoplasia of the humerus (HP:0006507)3.12334203
29Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.11684738
30Hypoplastic pelvis (HP:0008839)3.10549026
31Patellar aplasia (HP:0006443)3.10494409
32Aplasia/Hypoplasia of the spleen (HP:0010451)3.08917711
33Selective tooth agenesis (HP:0001592)3.08840797
34Decreased central vision (HP:0007663)3.08752664
35Abnormality of the phalanges of the 5th finger (HP:0004213)3.04768592
36Keratoconus (HP:0000563)3.01593421
37Increased corneal curvature (HP:0100692)3.01593421
38Abnormality of the proximal phalanges of the hand (HP:0009834)2.94865244
39Oral leukoplakia (HP:0002745)2.93417083
40Increased serum pyruvate (HP:0003542)2.89697574
41Abnormality of glycolysis (HP:0004366)2.89697574
42Genetic anticipation (HP:0003743)2.88016422
43Abnormality of cells of the erythroid lineage (HP:0012130)2.87187288
44Aplasia/Hypoplasia of the patella (HP:0006498)2.84862415
45Transposition of the great arteries (HP:0001669)2.81287940
46Abnormal connection of the cardiac segments (HP:0011545)2.81287940
47Abnormal ventriculo-arterial connection (HP:0011563)2.81287940
48Abnormal umbilical cord blood vessels (HP:0011403)2.81158271
49Single umbilical artery (HP:0001195)2.81158271
50Abnormality of the fetal cardiovascular system (HP:0010948)2.81158271
51Hypoplasia of the uterus (HP:0000013)2.81122135
52Abnormal number of erythroid precursors (HP:0012131)2.81048386
53Abnormality of the renal collecting system (HP:0004742)2.80430343
54Abnormality of the nasal septum (HP:0000419)2.75897867
55Abnormality of the 1st metacarpal (HP:0010009)2.74070945
56Trismus (HP:0000211)2.72148160
57Congenital stationary night blindness (HP:0007642)2.69585029
58Short humerus (HP:0005792)2.68354671
59Anomalous pulmonary venous return (HP:0010772)2.68025545
60Septo-optic dysplasia (HP:0100842)2.66844704
61Medulloblastoma (HP:0002885)2.66013016
62Methylmalonic acidemia (HP:0002912)2.65942854
63Abnormality of the middle phalanges of the toes (HP:0010183)2.57659646
64Abnormality of the labia minora (HP:0012880)2.57075551
65Abnormality of DNA repair (HP:0003254)2.55179167
66Hemivertebrae (HP:0002937)2.54548643
67Small hand (HP:0200055)2.53650103
68Abnormality of cochlea (HP:0000375)2.49921762
69Hyperglycinemia (HP:0002154)2.49640423
70* Breast aplasia (HP:0100783)2.49041679
71Chorioretinal atrophy (HP:0000533)2.47912095
72Male pseudohermaphroditism (HP:0000037)2.47292635
7311 pairs of ribs (HP:0000878)2.43947623
74Short hallux (HP:0010109)2.42826876
75Abnormal number of incisors (HP:0011064)2.39531692
76Short femoral neck (HP:0100864)2.39265081
77Absent thumb (HP:0009777)2.38327321
78Confusion (HP:0001289)2.37194698
79Premature ovarian failure (HP:0008209)2.36450426
80Progressive cerebellar ataxia (HP:0002073)2.36292093
81Short phalanx of the thumb (HP:0009660)2.35174803
82Porencephaly (HP:0002132)2.34841516
83Abnormality of the pulmonary veins (HP:0011718)2.34825179
84* Aplasia/Hypoplasia of the breasts (HP:0010311)2.34007972
85Aplasia/Hypoplasia of the sternum (HP:0006714)2.33468714
86Ependymoma (HP:0002888)2.33451857
87Abnormality of endocrine pancreas physiology (HP:0012093)2.33436458
88Abnormality of the pancreatic islet cells (HP:0006476)2.33436458
89Cystic liver disease (HP:0006706)2.32787693
90Agnosia (HP:0010524)2.32047001
91Cellular immunodeficiency (HP:0005374)2.30902460
92Symphalangism affecting the phalanges of the hand (HP:0009773)2.30381414
93Synostosis of carpal bones (HP:0005048)2.29623359
94Preauricular skin tag (HP:0000384)2.27194097
95Aplasia/Hypoplasia of the hallux (HP:0008362)2.26376338
96Long eyelashes (HP:0000527)2.26194011
97Sclerocornea (HP:0000647)2.26080349
98Missing ribs (HP:0000921)2.23713327
99Cleft eyelid (HP:0000625)2.23557242
100Aplasia/hypoplasia of the uterus (HP:0008684)2.23115277
101Meckel diverticulum (HP:0002245)2.22910370
102Coronal craniosynostosis (HP:0004440)2.22267230
103Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.21268937
104Short 4th metacarpal (HP:0010044)2.20561957
105Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.20561957
106Chromsome breakage (HP:0040012)2.19754952
107Chromosomal breakage induced by crosslinking agents (HP:0003221)2.18877192
108Anal stenosis (HP:0002025)2.15820598
109Late onset (HP:0003584)2.15582582
110Abnormality of the 4th metacarpal (HP:0010012)2.15155567
111Methylmalonic aciduria (HP:0012120)2.15109527
112Deviation of the thumb (HP:0009603)2.11406918
113Abnormality of the ileum (HP:0001549)2.11062576
114Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.09263150
115Macrocytic anemia (HP:0001972)2.08980106
116Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.08500151
117Anencephaly (HP:0002323)2.07573290
118Abnormality of the anterior horn cell (HP:0006802)2.07200890
119Degeneration of anterior horn cells (HP:0002398)2.07200890
120Cutaneous finger syndactyly (HP:0010554)2.06943424
121Facial cleft (HP:0002006)2.06436353
122Atresia of the external auditory canal (HP:0000413)2.05523304
123Skin tags (HP:0010609)2.05401467
124Mesomelia (HP:0003027)2.05392117
1253-Methylglutaconic aciduria (HP:0003535)2.05080018
126Progressive external ophthalmoplegia (HP:0000590)2.04945351
127Vertebral fusion (HP:0002948)2.04837845
128Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.04692354
129Abnormality of the 2nd finger (HP:0004100)2.04179677
130Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.03768142
131Aplastic anemia (HP:0001915)2.03747470
132Pallor (HP:0000980)2.00885023
133Proximal placement of thumb (HP:0009623)1.99792384
134Tracheoesophageal fistula (HP:0002575)1.99732086
135Abnormality of midbrain morphology (HP:0002418)1.98593480
136Molar tooth sign on MRI (HP:0002419)1.98593480
137Agitation (HP:0000713)1.97917647
138Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.96976471
139Aplasia/Hypoplasia of the tongue (HP:0010295)1.96591020
140Neoplasm of the pancreas (HP:0002894)1.95959198
141Anal atresia (HP:0002023)1.92788609
142Cerebral hypomyelination (HP:0006808)1.92087934
143Furrowed tongue (HP:0000221)1.91867786
144Oligodactyly (HP:0012165)1.91361673
145Morphological abnormality of the inner ear (HP:0011390)1.91009453
146Horseshoe kidney (HP:0000085)1.90697693
147Attenuation of retinal blood vessels (HP:0007843)1.90506372
148Congenital, generalized hypertrichosis (HP:0004540)1.90396025
149Bilateral microphthalmos (HP:0007633)1.89975794
150Aplasia/Hypoplasia of the sacrum (HP:0008517)1.89877039
151Nephronophthisis (HP:0000090)1.89785646
152Congenital sensorineural hearing impairment (HP:0008527)1.89656065
153Absent/shortened dynein arms (HP:0200106)1.89063248
154Dynein arm defect of respiratory motile cilia (HP:0012255)1.89063248
155Double outlet right ventricle (HP:0001719)1.88972591
156Congenital malformation of the right heart (HP:0011723)1.88972591
157Chronic hepatic failure (HP:0100626)1.88681665
158Acute necrotizing encephalopathy (HP:0006965)1.88220685
159Triphalangeal thumb (HP:0001199)1.87051634
160Abnormal pancreas size (HP:0012094)1.86140992
161Down-sloping shoulders (HP:0200021)1.85643409
162Rhabdomyosarcoma (HP:0002859)1.85424544
163Stenosis of the external auditory canal (HP:0000402)1.84984176
164Mitochondrial inheritance (HP:0001427)1.84394250
165Maternal diabetes (HP:0009800)1.81312535
166Short thumb (HP:0009778)1.80648222
167Basal cell carcinoma (HP:0002671)1.80366120
168Squamous cell carcinoma (HP:0002860)1.78552073
169Optic nerve hypoplasia (HP:0000609)1.78539897
170Rough bone trabeculation (HP:0100670)1.77265886
171Renal duplication (HP:0000075)1.77141509
172Aplasia/Hypoplasia of the uvula (HP:0010293)1.77136261
173Ectopic kidney (HP:0000086)1.76826459
174Carpal synostosis (HP:0009702)1.76130915
175Abnormality of alanine metabolism (HP:0010916)1.75661404
176Hyperalaninemia (HP:0003348)1.75661404
177Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.75661404
178Fused cervical vertebrae (HP:0002949)1.74298178
179Bicornuate uterus (HP:0000813)1.74134813
180Nephroblastoma (Wilms tumor) (HP:0002667)1.74091979
181Overlapping toe (HP:0001845)1.72461489
182Rectovaginal fistula (HP:0000143)1.71582451
183Rectal fistula (HP:0100590)1.71582451
184Broad thumb (HP:0011304)1.70495081
185Chronic bronchitis (HP:0004469)1.68124571

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB16.79641567
2LATS26.36325685
3GRK13.72899741
4CDC73.15484956
5PLK42.99882064
6ADRBK22.97849392
7WEE12.79169197
8CDK192.67290711
9TTK2.62820428
10PRKD22.61075579
11NUAK12.50363808
12TSSK62.38580341
13ZAK2.37422950
14EIF2AK12.35553031
15EPHA22.34017018
16SRPK12.19769334
17STK102.10031063
18MAP3K82.08110031
19VRK22.05005502
20PINK12.00905243
21PASK1.95926322
22PAK41.94193906
23PLK11.87020154
24FRK1.86140310
25NEK21.85622763
26TESK21.82562273
27VRK11.74739954
28PLK31.69070644
29CDK71.68314195
30TAF11.65871002
31TIE11.60216502
32AURKB1.56096528
33BMPR1B1.54974863
34WNK31.47697015
35MKNK11.47689764
36STK38L1.46725168
37AURKA1.41691106
38TNIK1.41415840
39TXK1.37695500
40MAP2K21.37443785
41TGFBR11.35907907
42BRAF1.35038847
43SGK21.28574751
44ACVR1B1.25000049
45MUSK1.23397444
46SGK4941.23112463
47SGK2231.23112463
48ERBB41.19698598
49MAP3K41.17451989
50TAOK31.16012644
51MAP4K21.15936368
52DYRK21.12059038
53CDK121.11498797
54NEK11.10863822
55ATR1.10057771
56EPHB21.08648611
57CHEK11.08033518
58INSRR1.07440486
59PRKCG1.06736066
60PAK11.05719405
61LATS11.05701354
62TLK11.04462002
63CHEK21.01274677
64RPS6KB21.01248634
65MAP2K71.00145043
66TESK10.98117550
67NTRK20.96392686
68PBK0.96313872
69WNK40.93931914
70MAP3K100.93573216
71PRKD30.92441452
72CSNK1G10.92004247
73KSR20.91121643
74EPHA40.90035252
75DYRK30.89043488
76KDR0.88895949
77CASK0.88005830
78MAP3K30.87331963
79RPS6KA60.87302707
80MKNK20.86636150
81PRKCH0.85467332
82OXSR10.84275676
83CDK80.83234426
84PLK20.82289607
85FGFR10.80858636
86RPS6KA40.79833900
87STK40.78131259
88CLK10.76207749
89MAPK130.75785970
90FLT30.75083444
91ADRBK10.73438135
92GRK70.73258765
93PRKCE0.72866289
94ABL20.71192335
95BLK0.71029493
96CDK20.69540824
97KIT0.69327192
98RPS6KL10.67251809
99RPS6KC10.67251809
100PAK30.67125998
101NME10.67012435
102ATM0.66909988
103CSNK1G20.66797970
104BRD40.66748104
105CDK90.66391492
106CSNK1A10.65445422
107ALK0.65332657
108CDK40.64876823
109NME20.64020318
110PRKACA0.63730139
111PIK3CA0.63392884
112MAP2K40.62725686
113STK110.62144602
114CSNK1E0.61827789
115CDK10.61324897
116STK160.59014738
117IKBKB0.58899633
118CSNK2A20.58257768
119SGK10.58202659
120SGK30.57746813
121PRKCQ0.56810472
122PDK20.56545089
123CSNK2A10.55985552
124GRK50.55974259
125MAP3K110.54690920
126CSNK1G30.54346638
127STK390.53879168
128NLK0.53367364
129EIF2AK30.52704162
130TEC0.52700287
131MELK0.52412372
132DAPK20.52020462
133PKN10.51514115
134RPS6KB10.51480410
135EEF2K0.50983582
136MAPKAPK50.50419071
137AKT20.48016905
138BCKDK0.47199832
139PRKCA0.46208204
140GRK60.45229296
141CDK60.44378320
142MATK0.44299546
143MAPK70.44005260
144CAMK2A0.43427499
145EIF2AK20.43420885
146ERBB20.43411555
147CAMK10.43324898
148CCNB10.42113816
149PRKCZ0.42094439
150LRRK20.40885853
151MAP3K90.40325099
152BRSK20.39165023
153BRSK10.36587424
154MAP3K70.36267614
155PRKCD0.36111458
156DAPK10.34717204
157MAP3K60.34360339
158LIMK10.34189074
159MOS0.31500816
160PRKDC0.30865929
161STK30.30705874
162MAP3K20.30704449
163RPS6KA50.30233296
164PIM10.29885109
165UHMK10.29604601
166PRKCI0.28400449
167DAPK30.26942366
168PTK20.26577395
169KSR10.25867886
170CDK11A0.24572540
171CDK140.24040624
172TTN0.23778060
173CDK150.23268512
174YES10.22671937
175MAP2K10.20865686
176CDK180.20448023
177RPS6KA10.19500138

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.23644225
2Mismatch repair_Homo sapiens_hsa034303.91214704
3Spliceosome_Homo sapiens_hsa030403.77832775
4RNA polymerase_Homo sapiens_hsa030203.69614081
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.50436320
6One carbon pool by folate_Homo sapiens_hsa006703.38887727
7Proteasome_Homo sapiens_hsa030503.24878595
8Ribosome_Homo sapiens_hsa030103.22908592
9RNA transport_Homo sapiens_hsa030133.09084719
10Basal cell carcinoma_Homo sapiens_hsa052172.74404907
11Cell cycle_Homo sapiens_hsa041102.72684715
12Homologous recombination_Homo sapiens_hsa034402.67241456
13Base excision repair_Homo sapiens_hsa034102.67218483
14Hedgehog signaling pathway_Homo sapiens_hsa043402.48659290
15Pyrimidine metabolism_Homo sapiens_hsa002402.46951631
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.44391813
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.43175177
18Nucleotide excision repair_Homo sapiens_hsa034202.38882893
19RNA degradation_Homo sapiens_hsa030182.33196381
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.11159012
21Phototransduction_Homo sapiens_hsa047442.02964284
22Linoleic acid metabolism_Homo sapiens_hsa005911.95616074
23Fanconi anemia pathway_Homo sapiens_hsa034601.90935348
24Nicotine addiction_Homo sapiens_hsa050331.89793711
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.89642914
26Caffeine metabolism_Homo sapiens_hsa002321.85759932
27p53 signaling pathway_Homo sapiens_hsa041151.85348568
28Sulfur relay system_Homo sapiens_hsa041221.76361632
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.75283557
30Basal transcription factors_Homo sapiens_hsa030221.75145804
31Chemical carcinogenesis_Homo sapiens_hsa052041.66781352
32Hippo signaling pathway_Homo sapiens_hsa043901.65637027
33Sulfur metabolism_Homo sapiens_hsa009201.63582642
34mRNA surveillance pathway_Homo sapiens_hsa030151.58357916
35Cardiac muscle contraction_Homo sapiens_hsa042601.55660755
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.53687883
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.50883979
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.48265449
39Alzheimers disease_Homo sapiens_hsa050101.43753997
40Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.42615163
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.41004066
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.38786092
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.37797881
44Biosynthesis of amino acids_Homo sapiens_hsa012301.35627396
45Oocyte meiosis_Homo sapiens_hsa041141.34365025
46Nitrogen metabolism_Homo sapiens_hsa009101.32619429
47TGF-beta signaling pathway_Homo sapiens_hsa043501.31201382
48Steroid hormone biosynthesis_Homo sapiens_hsa001401.29563079
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.27110602
50Purine metabolism_Homo sapiens_hsa002301.26287863
51Morphine addiction_Homo sapiens_hsa050321.24032146
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.23879991
53Taste transduction_Homo sapiens_hsa047421.17073607
54Cyanoamino acid metabolism_Homo sapiens_hsa004601.15080253
55Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.13958231
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.13681013
57Vitamin digestion and absorption_Homo sapiens_hsa049771.12987393
58Olfactory transduction_Homo sapiens_hsa047401.12088224
59Non-homologous end-joining_Homo sapiens_hsa034501.11760054
60Tryptophan metabolism_Homo sapiens_hsa003801.08699778
61Wnt signaling pathway_Homo sapiens_hsa043101.07793916
62HTLV-I infection_Homo sapiens_hsa051661.04617481
63MicroRNAs in cancer_Homo sapiens_hsa052061.00844551
64Melanogenesis_Homo sapiens_hsa049160.98927840
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97463495
66Fat digestion and absorption_Homo sapiens_hsa049750.97033857
67Epstein-Barr virus infection_Homo sapiens_hsa051690.89881260
68Insulin secretion_Homo sapiens_hsa049110.89832029
69Primary immunodeficiency_Homo sapiens_hsa053400.89559039
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89051071
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87486898
72Ether lipid metabolism_Homo sapiens_hsa005650.87041325
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85535578
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81145672
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.80936565
76Glutamatergic synapse_Homo sapiens_hsa047240.80071033
77Serotonergic synapse_Homo sapiens_hsa047260.79039246
78Thyroid cancer_Homo sapiens_hsa052160.78291057
79Arachidonic acid metabolism_Homo sapiens_hsa005900.78101517
80Bladder cancer_Homo sapiens_hsa052190.77174469
81Adherens junction_Homo sapiens_hsa045200.73728309
82Selenocompound metabolism_Homo sapiens_hsa004500.72773043
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71978334
84Intestinal immune network for IgA production_Homo sapiens_hsa046720.70988622
85Peroxisome_Homo sapiens_hsa041460.70767475
86GABAergic synapse_Homo sapiens_hsa047270.70346722
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70090314
88Huntingtons disease_Homo sapiens_hsa050160.69325319
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.69309795
90Systemic lupus erythematosus_Homo sapiens_hsa053220.68348400
91* Melanoma_Homo sapiens_hsa052180.67479289
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65561858
93Phenylalanine metabolism_Homo sapiens_hsa003600.64687456
94Circadian entrainment_Homo sapiens_hsa047130.63892618
95Viral carcinogenesis_Homo sapiens_hsa052030.63294272
96Dorso-ventral axis formation_Homo sapiens_hsa043200.61825814
97Glycerolipid metabolism_Homo sapiens_hsa005610.61235685
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59960629
99* Pathways in cancer_Homo sapiens_hsa052000.59314368
100Renin-angiotensin system_Homo sapiens_hsa046140.58563292
101Axon guidance_Homo sapiens_hsa043600.54413721
102Carbon metabolism_Homo sapiens_hsa012000.53206353
103Cholinergic synapse_Homo sapiens_hsa047250.51943008
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49957959
105Colorectal cancer_Homo sapiens_hsa052100.49544505
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48945989
107Drug metabolism - other enzymes_Homo sapiens_hsa009830.47550742
108Notch signaling pathway_Homo sapiens_hsa043300.47368759
109Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.47057322
110Retinol metabolism_Homo sapiens_hsa008300.46250231
111Proteoglycans in cancer_Homo sapiens_hsa052050.45370626
112Butanoate metabolism_Homo sapiens_hsa006500.44405766
113Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43611099
114Tight junction_Homo sapiens_hsa045300.42909023
115Parkinsons disease_Homo sapiens_hsa050120.42829725
116HIF-1 signaling pathway_Homo sapiens_hsa040660.42493527
117Protein export_Homo sapiens_hsa030600.42235668
118Pyruvate metabolism_Homo sapiens_hsa006200.41573141
119Salivary secretion_Homo sapiens_hsa049700.40085579
120cAMP signaling pathway_Homo sapiens_hsa040240.39621959
121Folate biosynthesis_Homo sapiens_hsa007900.38851653
122Ovarian steroidogenesis_Homo sapiens_hsa049130.38193361
123Herpes simplex infection_Homo sapiens_hsa051680.36993303
124Calcium signaling pathway_Homo sapiens_hsa040200.36181565
125Primary bile acid biosynthesis_Homo sapiens_hsa001200.35817449
126Starch and sucrose metabolism_Homo sapiens_hsa005000.34783042
127Small cell lung cancer_Homo sapiens_hsa052220.30799416
128Oxidative phosphorylation_Homo sapiens_hsa001900.30579301
129Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27766179
130Shigellosis_Homo sapiens_hsa051310.27549957
131Apoptosis_Homo sapiens_hsa042100.26201625
1322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.24213652
133Tyrosine metabolism_Homo sapiens_hsa003500.21330704
134Legionellosis_Homo sapiens_hsa051340.20063873
135Glutathione metabolism_Homo sapiens_hsa004800.17954217
136Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.16427964
137Pentose phosphate pathway_Homo sapiens_hsa000300.16008728
138Arginine and proline metabolism_Homo sapiens_hsa003300.14346242
139Alcoholism_Homo sapiens_hsa050340.14023978
140Viral myocarditis_Homo sapiens_hsa054160.12890676
141Metabolic pathways_Homo sapiens_hsa011000.12214167
142* Rap1 signaling pathway_Homo sapiens_hsa040150.11434977
143Prion diseases_Homo sapiens_hsa050200.10061681
144* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.09448973
145Antigen processing and presentation_Homo sapiens_hsa046120.08969496
146Endometrial cancer_Homo sapiens_hsa052130.08623612
147* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.08419941
148Transcriptional misregulation in cancer_Homo sapiens_hsa052020.08350358
149Gap junction_Homo sapiens_hsa045400.07434054
150Glucagon signaling pathway_Homo sapiens_hsa049220.06484187
151Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.05655658
152Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.05060123
153Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.05008157
154mTOR signaling pathway_Homo sapiens_hsa041500.03923039
155Prostate cancer_Homo sapiens_hsa052150.03353900
156Hepatitis B_Homo sapiens_hsa051610.01769876
157Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.01758775
158Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.01582648
159Vitamin B6 metabolism_Homo sapiens_hsa007500.00771517

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