FGFBP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the fibroblast growth factor binding protein family. The encoded protein is a serum protein that is selectively secreted by cytotoxic lymphocytes and may be involved in cytotoxic lymphocyte-mediated immunity. An increase in the amount of gene product may be associated with atopic asthma and mild extrinsic asthma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G7.71194526
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)7.36374992
3negative regulation of cell killing (GO:0031342)7.36374992
4leukocyte aggregation (GO:0070486)5.66743330
5activated T cell proliferation (GO:0050798)5.40809870
6positive regulation of gamma-delta T cell activation (GO:0046645)5.32460902
7regulation of B cell receptor signaling pathway (GO:0050855)5.26795954
8T cell migration (GO:0072678)5.14283843
9neutrophil activation involved in immune response (GO:0002283)5.04411975
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.77055943
11regulation of natural killer cell mediated immunity (GO:0002715)4.75953497
12regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.75953497
13cellular response to interleukin-15 (GO:0071350)4.71221460
14negative regulation of phagocytosis (GO:0050765)4.66383278
15negative regulation of stress fiber assembly (GO:0051497)4.38436385
16response to interleukin-15 (GO:0070672)4.31810801
17macrophage activation involved in immune response (GO:0002281)4.18226408
18positive regulation of T cell mediated cytotoxicity (GO:0001916)4.14057274
19positive regulation of natural killer cell mediated immunity (GO:0002717)4.12410920
20lymphocyte migration (GO:0072676)4.10252181
21negative regulation of lymphocyte mediated immunity (GO:0002707)4.04578326
22negative T cell selection (GO:0043383)4.00642774
23positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.96002257
24regulation of T cell tolerance induction (GO:0002664)3.95773320
25neutrophil activation (GO:0042119)3.95200195
26regulation of T cell mediated cytotoxicity (GO:0001914)3.93962034
27regulation of gamma-delta T cell differentiation (GO:0045586)3.93631144
28positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.89388199
29regulation of gamma-delta T cell activation (GO:0046643)3.86437506
30regulation of leukocyte mediated cytotoxicity (GO:0001910)3.85413022
31cytidine deamination (GO:0009972)3.82711945
32cytidine metabolic process (GO:0046087)3.82711945
33cytidine catabolic process (GO:0006216)3.82711945
34modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.81793589
35positive regulation by organism of defense response of other organism involved in symbiotic interact3.81793589
36modulation by symbiont of host immune response (GO:0052553)3.81793589
37positive regulation by symbiont of host defense response (GO:0052509)3.81793589
38modulation by symbiont of host defense response (GO:0052031)3.81793589
39modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.81793589
40positive thymic T cell selection (GO:0045059)3.81475907
41negative thymic T cell selection (GO:0045060)3.74899373
42negative regulation of leukocyte mediated immunity (GO:0002704)3.71322059
43detection of bacterium (GO:0016045)3.67471934
44regulation of regulatory T cell differentiation (GO:0045589)3.64265888
45cytolysis (GO:0019835)3.63583091
46detection of other organism (GO:0098543)3.63030128
47interferon-gamma production (GO:0032609)3.61660605
48positive T cell selection (GO:0043368)3.61034190
49antigen processing and presentation via MHC class Ib (GO:0002475)3.52503724
50respiratory burst (GO:0045730)3.51930648
51granulocyte activation (GO:0036230)3.50563247
52positive regulation of cell killing (GO:0031343)3.50177878
53regulation of tolerance induction (GO:0002643)3.48600375
54type I interferon signaling pathway (GO:0060337)3.47953717
55cellular response to type I interferon (GO:0071357)3.47953717
56regulation of B cell differentiation (GO:0045577)3.46580082
57positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.46128827
58response to type I interferon (GO:0034340)3.45006364
59pyrimidine ribonucleoside catabolic process (GO:0046133)3.43736259
60cellular defense response (GO:0006968)3.43509073
61regulation of cell killing (GO:0031341)3.40403236
62maturation of SSU-rRNA (GO:0030490)3.38109831
63positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.34102296
64T cell receptor signaling pathway (GO:0050852)3.31325228
65myeloid cell activation involved in immune response (GO:0002275)3.28454102
66T cell selection (GO:0045058)3.24978938
67thymic T cell selection (GO:0045061)3.24450044
68immunoglobulin mediated immune response (GO:0016064)3.24275800
69lymphocyte chemotaxis (GO:0048247)3.23780853
70microglial cell activation (GO:0001774)3.21647771
71cellular extravasation (GO:0045123)3.17575106
72positive regulation of tolerance induction (GO:0002645)3.17152951
73negative regulation of actin filament bundle assembly (GO:0032232)3.16024937
74positive regulation of mast cell activation (GO:0033005)3.15239210
75regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.14585256
76mast cell activation (GO:0045576)3.11717723
77regulation of isotype switching to IgG isotypes (GO:0048302)3.10899721
78antigen receptor-mediated signaling pathway (GO:0050851)3.10831244
79regulation of alpha-beta T cell proliferation (GO:0046640)3.08806585
80leukocyte migration involved in inflammatory response (GO:0002523)3.08646823
81heart trabecula morphogenesis (GO:0061384)3.02307036
82regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.99800064
83positive regulation of interleukin-17 production (GO:0032740)2.99490838
84positive regulation of isotype switching (GO:0045830)2.98090149
85NIK/NF-kappaB signaling (GO:0038061)2.97476111
86DNA deamination (GO:0045006)2.95760038
87positive regulation of lymphocyte mediated immunity (GO:0002708)2.95706719
88regulation of activation of Janus kinase activity (GO:0010533)2.93239389
89negative regulation of T cell mediated immunity (GO:0002710)2.92880834
90macrophage chemotaxis (GO:0048246)2.91671385
91positive regulation of B cell differentiation (GO:0045579)2.91312153
92positive regulation of B cell mediated immunity (GO:0002714)2.90920725
93positive regulation of immunoglobulin mediated immune response (GO:0002891)2.90920725
94leukocyte cell-cell adhesion (GO:0007159)2.90436429
95Arp2/3 complex-mediated actin nucleation (GO:0034314)2.89900435
96trabecula morphogenesis (GO:0061383)2.87699749
97negative regulation of innate immune response (GO:0045824)2.85703483
98antigen processing and presentation of endogenous peptide antigen (GO:0002483)11.7792905
99antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)11.3778712
100antigen processing and presentation of endogenous antigen (GO:0019883)10.3549435

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.39442237
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.21214273
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.55761478
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.33284104
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.90609268
6RUNX_20019798_ChIP-Seq_JUKART_Human3.68899929
7MYB_26560356_Chip-Seq_TH2_Human2.85738519
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.80292601
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.77882686
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.72577451
11UTX_26944678_Chip-Seq_JUKART_Human2.70719142
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.66924070
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.65358453
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.61788713
15MAF_26560356_Chip-Seq_TH1_Human2.54664224
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.45786606
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.43915449
18FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.36092685
19MYB_26560356_Chip-Seq_TH1_Human2.34421259
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.25444662
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.20261373
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.16875648
23IRF8_27001747_Chip-Seq_BMDM_Mouse2.10682716
24SPI1_23547873_ChIP-Seq_NB4_Human2.09158805
25E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.08436637
26VDR_24763502_ChIP-Seq_THP-1_Human2.06543920
27RUNX1_22412390_ChIP-Seq_EML_Mouse1.94827707
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.94788114
29* GATA3_27048872_Chip-Seq_THYMUS_Human1.92751751
30SPI1_23127762_ChIP-Seq_K562_Human1.91325041
31MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.85564548
32MAF_26560356_Chip-Seq_TH2_Human1.83670267
33LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.80675193
34VDR_21846776_ChIP-Seq_THP-1_Human1.80232654
35CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.78087251
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.76069664
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.73081403
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.70192746
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.67307378
40LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.66744268
41GATA3_26560356_Chip-Seq_TH2_Human1.65678645
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.61688303
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.61472125
44GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.53573841
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.48390226
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.47462750
47VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.43882335
48GATA1_19941827_ChIP-Seq_MEL_Mouse1.37577508
49TCF7_22412390_ChIP-Seq_EML_Mouse1.33582073
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.33314656
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.33189993
52MYB_21317192_ChIP-Seq_ERMYB_Mouse1.32511801
53BCL6_27268052_Chip-Seq_Bcells_Human1.30484003
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.27577886
55KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.27061789
56SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24342709
57TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23697151
58MYC_22102868_ChIP-Seq_BL_Human1.21216432
59VDR_24787735_ChIP-Seq_THP-1_Human1.19618061
60PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15352412
61RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13417363
62KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.13234170
63SCL_19346495_ChIP-Seq_HPC-7_Human1.13051748
64KDM2B_26808549_Chip-Seq_DND41_Human1.11386961
65RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.10210046
66EGR1_19032775_ChIP-ChIP_M12_Human1.09494064
67SA1_27219007_Chip-Seq_Bcells_Human1.08528051
68EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05834064
69CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03923422
70CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03765838
71RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.02642369
72NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.02388172
73LXR_22292898_ChIP-Seq_THP-1_Human1.01840354
74ELF1_20517297_ChIP-Seq_JURKAT_Human0.95794881
75YY1_22570637_ChIP-Seq_MALME-3M_Human0.95565275
76CTCF_26484167_Chip-Seq_Bcells_Mouse0.95248009
77CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94770645
78RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94237214
79BCOR_27268052_Chip-Seq_Bcells_Human0.94132038
80* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.92772178
81CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92216904
82SA1_27219007_Chip-Seq_ERYTHROID_Human0.91799305
83PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90414440
84THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.90030376
85GATA2_22383799_ChIP-Seq_G1ME_Mouse0.89980298
86E2F1_20622854_ChIP-Seq_HELA_Human0.89904891
87KDM2B_26808549_Chip-Seq_JURKAT_Human0.89468667
88CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89150992
89GATA1_19941826_ChIP-Seq_K562_Human0.88374671
90SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87725449
91SPI1_20517297_ChIP-Seq_HL60_Human0.87667618
92TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.85315530
93BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.82828617
94EGR1_23403033_ChIP-Seq_LIVER_Mouse0.81654200
95NANOG_20526341_ChIP-Seq_ESCs_Human0.81417739
96PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.79341869
97PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78237674
98SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.77843180
99GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77733592
100ELK3_25401928_ChIP-Seq_HUVEC_Human0.77464503

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.33405470
2MP0005671_abnormal_response_to5.14715686
3MP0006082_CNS_inflammation4.99930904
4MP0003724_increased_susceptibility_to3.59095410
5MP0003436_decreased_susceptibility_to3.33391926
6MP0001800_abnormal_humoral_immune3.23676066
7MP0005025_abnormal_response_to3.13841627
8MP0009785_altered_susceptibility_to3.13216354
9MP0005000_abnormal_immune_tolerance3.03666053
10MP0003763_abnormal_thymus_physiology2.98520545
11MP0002419_abnormal_innate_immunity2.86328246
12MP0002420_abnormal_adaptive_immunity2.83563552
13MP0005387_immune_system_phenotype2.79881479
14MP0001790_abnormal_immune_system2.79881479
15MP0002723_abnormal_immune_serum2.77914026
16MP0001819_abnormal_immune_cell2.77011055
17MP0002452_abnormal_antigen_presenting2.68156555
18MP0009333_abnormal_splenocyte_physiolog2.56987948
19MP0000685_abnormal_immune_system2.39506098
20MP0002132_abnormal_respiratory_system2.22874471
21MP0010155_abnormal_intestine_physiology2.15337460
22MP0002405_respiratory_system_inflammati2.11535329
23MP0000716_abnormal_immune_system2.09598180
24MP0002398_abnormal_bone_marrow2.05970163
25MP0000858_altered_metastatic_potential2.05891500
26MP0001873_stomach_inflammation1.98542400
27MP0003300_gastrointestinal_ulcer1.92783733
28MP0002148_abnormal_hypersensitivity_rea1.81376891
29MP0005464_abnormal_platelet_physiology1.79453924
30MP0002138_abnormal_hepatobiliary_system1.77803331
31MP0001845_abnormal_inflammatory_respons1.74590903
32MP0002933_joint_inflammation1.72459912
33MP0002722_abnormal_immune_system1.72189956
34MP0003690_abnormal_glial_cell1.68743774
35MP0000689_abnormal_spleen_morphology1.67251450
36MP0001851_eye_inflammation1.62645403
37MP0000703_abnormal_thymus_morphology1.61697536
38MP0003866_abnormal_defecation1.61425302
39MP0001533_abnormal_skeleton_physiology1.60923450
40MP0002429_abnormal_blood_cell1.58222864
41MP0003448_altered_tumor_morphology1.58162485
42MP0003303_peritoneal_inflammation1.53837880
43MP0001348_abnormal_lacrimal_gland1.46784590
44MP0008469_abnormal_protein_level1.45669614
45MP0004947_skin_inflammation1.45020394
46MP0002277_abnormal_respiratory_mucosa1.34571724
47MP0005310_abnormal_salivary_gland1.34219605
48MP0002998_abnormal_bone_remodeling1.32511994
49MP0001986_abnormal_taste_sensitivity1.28238405
50MP0005166_decreased_susceptibility_to1.26557684
51MP0006054_spinal_hemorrhage1.25128069
52MP0002166_altered_tumor_susceptibility1.23410357
53MP0004510_myositis1.16279791
54MP0004381_abnormal_hair_follicle1.13351755
55MP0003195_calcinosis1.09731051
56MP0009763_increased_sensitivity_to1.05113394
57MP0001663_abnormal_digestive_system1.04014388
58MP0004883_abnormal_blood_vessel1.02018501
59MP0000490_abnormal_crypts_of0.99483078
60MP0003646_muscle_fatigue0.97143022
61MP0005164_abnormal_response_to0.94603750
62MP0009764_decreased_sensitivity_to0.92627976
63MP0008260_abnormal_autophagy0.92175292
64MP0000465_gastrointestinal_hemorrhage0.88047283
65MP0001529_abnormal_vocalization0.83105401
66MP0001727_abnormal_embryo_implantation0.82448971
67MP0003045_fibrosis0.75184733
68MP0003828_pulmonary_edema0.74777786
69MP0003879_abnormal_hair_cell0.70059324
70MP0002006_tumorigenesis0.69983470
71MP0003252_abnormal_bile_duct0.69101896
72MP0005381_digestive/alimentary_phenotyp0.65810435
73MP0005075_abnormal_melanosome_morpholog0.65306493
74MP0004130_abnormal_muscle_cell0.64828836
75MP0000920_abnormal_myelination0.64514282
76MP0003795_abnormal_bone_structure0.64317295
77MP0003075_altered_response_to0.63109579
78MP0003191_abnormal_cellular_cholesterol0.62417725
79MP0008873_increased_physiological_sensi0.59457178
80MP0003011_delayed_dark_adaptation0.58332266
81MP0008874_decreased_physiological_sensi0.57689159
82MP0003567_abnormal_fetal_cardiomyocyte0.57419275
83MP0008004_abnormal_stomach_pH0.56976320
84MP0002693_abnormal_pancreas_physiology0.56241812
85MP0002254_reproductive_system_inflammat0.55967597
86MP0000343_altered_response_to0.55037612
87MP0005390_skeleton_phenotype0.54808277
88MP0000249_abnormal_blood_vessel0.52499700
89MP0001853_heart_inflammation0.50681413
90MP0000750_abnormal_muscle_regeneration0.50324822
91MP0003172_abnormal_lysosome_physiology0.48590255
92MP0001905_abnormal_dopamine_level0.47160183
93MP0005377_hearing/vestibular/ear_phenot0.47113252
94MP0003878_abnormal_ear_physiology0.47113252
95MP0002019_abnormal_tumor_incidence0.47050576
96MP0002127_abnormal_cardiovascular_syste0.45401851
97MP0005595_abnormal_vascular_smooth0.41515138
98MP0001765_abnormal_ion_homeostasis0.41413898
99MP0002928_abnormal_bile_duct0.39744306
100MP0001919_abnormal_reproductive_system0.37835413

Predicted human phenotypes

RankGene SetZ-score
1Chronic otitis media (HP:0000389)8.63048355
2Nasal polyposis (HP:0100582)7.87769060
3Abnormality of the nasal mucosa (HP:0000433)6.59407958
4Recurrent abscess formation (HP:0002722)5.93918795
5Recurrent bronchitis (HP:0002837)5.68139736
6Chronic sinusitis (HP:0011109)5.60731445
7Recurrent bacterial skin infections (HP:0005406)5.48288623
8Eczematoid dermatitis (HP:0000976)5.15984418
9Elevated erythrocyte sedimentation rate (HP:0003565)5.05810051
10Recurrent gram-negative bacterial infections (HP:0005420)4.91595995
11Abnormality of macrophages (HP:0004311)4.77182748
12T lymphocytopenia (HP:0005403)4.72118510
13Abnormality of T cell number (HP:0011839)4.60027556
14Myositis (HP:0100614)4.55397611
15Pustule (HP:0200039)4.36843805
16Orchitis (HP:0100796)3.75932888
17Encephalitis (HP:0002383)3.69810743
18Bronchitis (HP:0012387)3.52976748
19Retrobulbar optic neuritis (HP:0100654)3.50558223
20Optic neuritis (HP:0100653)3.50558223
21Recurrent skin infections (HP:0001581)3.48442428
22Stomatitis (HP:0010280)3.48224212
23Hemiplegia (HP:0002301)3.47220016
24Abnormality of T cells (HP:0002843)3.45793407
25Recurrent fungal infections (HP:0002841)3.42940262
26Leukocytosis (HP:0001974)3.41623714
27Gingivitis (HP:0000230)3.40959809
28Increased IgM level (HP:0003496)3.36125717
29Meningitis (HP:0001287)3.35437466
30Abnormal delayed hypersensitivity skin test (HP:0002963)3.24448842
31Hypothermia (HP:0002045)3.15447229
32Increased IgE level (HP:0003212)3.15021961
33Eosinophilia (HP:0001880)3.13216530
34Hypoproteinemia (HP:0003075)3.12577589
35Emphysema (HP:0002097)3.01649216
36Spontaneous hematomas (HP:0007420)2.98917313
37Global brain atrophy (HP:0002283)2.95621781
38Agammaglobulinemia (HP:0004432)2.93114946
39Gastrointestinal infarctions (HP:0005244)2.92850245
40Autoimmune hemolytic anemia (HP:0001890)2.92326647
41Absent rod-and cone-mediated responses on ERG (HP:0007688)2.92183543
42Granulocytopenia (HP:0001913)2.92118701
43Chronic mucocutaneous candidiasis (HP:0002728)2.89694717
44Recurrent cutaneous fungal infections (HP:0011370)2.89694717
45Obstructive lung disease (HP:0006536)2.88741366
46Chronic obstructive pulmonary disease (HP:0006510)2.88741366
47Keratoconjunctivitis (HP:0001096)2.80998476
48Periodontitis (HP:0000704)2.75571713
49Abnormality of eosinophils (HP:0001879)2.75558550
50Vasculitis (HP:0002633)2.73758130
51Joint swelling (HP:0001386)2.73707960
52Mediastinal lymphadenopathy (HP:0100721)2.69812036
53Keratoconjunctivitis sicca (HP:0001097)2.67916190
54Abnormal rod and cone electroretinograms (HP:0008323)2.65658360
55Recurrent viral infections (HP:0004429)2.63319198
56Hypergammaglobulinemia (HP:0010702)2.62378285
57Chronic diarrhea (HP:0002028)2.52091870
58Lymphopenia (HP:0001888)2.51459450
59Severe combined immunodeficiency (HP:0004430)2.51351060
60Panhypogammaglobulinemia (HP:0003139)2.50917249
61Metaphyseal cupping (HP:0003021)2.47017365
62Abnormality of cells of the lymphoid lineage (HP:0012140)2.44237627
63Urticaria (HP:0001025)2.41794144
64Prolonged bleeding time (HP:0003010)2.39603087
65Hypochromic anemia (HP:0001931)2.36478354
66Constricted visual fields (HP:0001133)2.34443887
67Bronchiectasis (HP:0002110)2.30552709
68Alveolar cell carcinoma (HP:0006519)2.29372293
69Hypochromic microcytic anemia (HP:0004840)2.25658790
70Inflammation of the large intestine (HP:0002037)2.23366391
71Chest pain (HP:0100749)2.16972073
72Pulmonary embolism (HP:0002204)2.14611828
73Recurrent otitis media (HP:0000403)2.12052529
74Gastrointestinal inflammation (HP:0004386)2.11146424
75Autoimmune thrombocytopenia (HP:0001973)2.11092301
76Microcytic anemia (HP:0001935)2.10995347
77Anorexia (HP:0002039)2.09420131
78Increased serum ferritin (HP:0003281)2.08638499
79Premature loss of primary teeth (HP:0006323)2.07928574
80Gingival bleeding (HP:0000225)2.07889534
81Neoplasm of the tracheobronchial system (HP:0100552)2.07106803
82Ectopia lentis (HP:0001083)2.04840879
83Pulmonary infiltrates (HP:0002113)2.03265749
84Hemoptysis (HP:0002105)2.03259514
85Abnormality of T cell physiology (HP:0011840)2.02791506
86Purpura (HP:0000979)2.02682191
87Thick nail (HP:0001805)2.02215290
88Diplopia (HP:0000651)2.01723393
89Abnormality of binocular vision (HP:0011514)2.01723393
90Acute hepatic failure (HP:0006554)2.01600969
91Papilledema (HP:0001085)1.98997432
92Epistaxis (HP:0000421)1.96713634
93Cellulitis (HP:0100658)1.95700731
94Skin ulcer (HP:0200042)1.94928596
95Combined immunodeficiency (HP:0005387)1.93328544
96IgG deficiency (HP:0004315)1.91309781
97Striae distensae (HP:0001065)1.87673120
98Attenuation of retinal blood vessels (HP:0007843)1.85289974
99IgM deficiency (HP:0002850)1.82482975
100Abnormality of iron homeostasis (HP:0011031)1.82386863

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K138.13472029
2MAP4K14.16894004
3TAOK33.31848578
4TLK13.16401653
5FES3.00903840
6TXK2.97266565
7TESK22.47897741
8RIPK42.34135906
9MAP3K142.31033869
10CSK2.26638890
11KDR2.25368840
12ZAP702.20664115
13BMPR22.01612821
14ARAF1.96829748
15TNK21.88499298
16BTK1.85695756
17TYK21.70968615
18GRK61.70946972
19ERN11.69899524
20SYK1.60524736
21MAP3K91.58091402
22ITK1.57479492
23HCK1.46518852
24BLK1.45570544
25MOS1.43506422
26TESK11.42380985
27LCK1.39636312
28KSR21.39375807
29FGR1.26446048
30MAP3K71.25047463
31IRAK41.14354654
32MAP2K31.14146437
33JAK11.12523114
34LYN1.09989951
35GRK71.08632931
36TEC1.06793456
37KIT1.06687586
38BRAF1.04729375
39PRPF4B1.04560087
40EPHB11.04205081
41PRKCH1.02756415
42IKBKB1.00484326
43PRKCQ0.98800767
44JAK30.92473761
45MAP3K110.90024023
46STK100.85022158
47IKBKE0.84959125
48PASK0.80367792
49TBK10.80129274
50PDK10.79859272
51CSF1R0.79025224
52MAP3K10.75368835
53ILK0.74737639
54MAP3K30.72707479
55MAP3K80.72300802
56FYN0.66361852
57STK380.66095253
58MAP3K120.64640740
59TGFBR20.62543053
60RAF10.60963815
61JAK20.60353991
62MAP2K60.57321492
63SIK30.55124007
64PTK60.52603206
65PIM10.51632573
66TAOK10.51569681
67PDPK10.51374589
68PTK2B0.51278031
69MARK30.50127985
70LIMK10.47040832
71LRRK20.44982401
72ADRBK20.40710073
73PRKD20.39937586
74CDK40.39549610
75PIK3CG0.37214113
76SIK20.37126864
77KSR10.36489319
78TYRO30.32875811
79INSR0.29829319
80CAMKK10.29104648
81ADRBK10.28086383
82MAPK120.28055111
83TAOK20.26041951
84CHUK0.22162732
85IGF1R0.21094932
86MYLK0.21051280
87MARK20.20806044
88ABL10.18938638
89YES10.18843327
90MAPK70.18770557
91MAPKAPK20.18107606
92CDC42BPA0.16613412
93TTN0.16598152
94PDGFRB0.16108609
95PRKAA20.15050230
96GRK50.14570285
97BCKDK0.14494069
98MAP2K20.13810427
99MAPK40.13028587
100SRC0.12496126

Predicted pathways (KEGG)

RankGene SetZ-score
1Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046504.43448110
2Graft-versus-host disease_Homo sapiens_hsa053323.91481452
3Primary immunodeficiency_Homo sapiens_hsa053403.58733380
4Antigen processing and presentation_Homo sapiens_hsa046123.27760821
5Allograft rejection_Homo sapiens_hsa053303.05698332
6Autoimmune thyroid disease_Homo sapiens_hsa053202.99103210
7T cell receptor signaling pathway_Homo sapiens_hsa046602.68952440
8Staphylococcus aureus infection_Homo sapiens_hsa051502.54180657
9Type I diabetes mellitus_Homo sapiens_hsa049402.42071518
10Osteoclast differentiation_Homo sapiens_hsa043802.39577010
11Leishmaniasis_Homo sapiens_hsa051402.35999833
12Viral myocarditis_Homo sapiens_hsa054162.32840554
13Malaria_Homo sapiens_hsa051442.27850801
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.91393954
15Hematopoietic cell lineage_Homo sapiens_hsa046401.90008329
16B cell receptor signaling pathway_Homo sapiens_hsa046621.88375702
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.79420502
18Measles_Homo sapiens_hsa051621.61628226
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.59145532
20Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.46377519
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.42643804
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.42470218
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.36745770
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.35984226
25Chemokine signaling pathway_Homo sapiens_hsa040621.31222033
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.29860494
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.29101386
28Tuberculosis_Homo sapiens_hsa051521.27666926
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.24225937
30Linoleic acid metabolism_Homo sapiens_hsa005911.18468466
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.18284939
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.17571952
33Acute myeloid leukemia_Homo sapiens_hsa052211.14700730
34Shigellosis_Homo sapiens_hsa051311.05212762
35Apoptosis_Homo sapiens_hsa042101.03324162
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99836181
37Rheumatoid arthritis_Homo sapiens_hsa053230.99287114
38Jak-STAT signaling pathway_Homo sapiens_hsa046300.99264028
39Legionellosis_Homo sapiens_hsa051340.98656838
40Phagosome_Homo sapiens_hsa041450.95446078
41TNF signaling pathway_Homo sapiens_hsa046680.93452461
42Pertussis_Homo sapiens_hsa051330.92323447
43Herpes simplex infection_Homo sapiens_hsa051680.91783341
44Influenza A_Homo sapiens_hsa051640.91664145
45Toxoplasmosis_Homo sapiens_hsa051450.90249430
46Pancreatic cancer_Homo sapiens_hsa052120.89528558
47Platelet activation_Homo sapiens_hsa046110.85759423
48Asthma_Homo sapiens_hsa053100.84632533
49Hepatitis C_Homo sapiens_hsa051600.83182905
50Non-small cell lung cancer_Homo sapiens_hsa052230.78530311
51Ribosome_Homo sapiens_hsa030100.76358468
52African trypanosomiasis_Homo sapiens_hsa051430.75387380
53Sphingolipid signaling pathway_Homo sapiens_hsa040710.73475995
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66671663
55VEGF signaling pathway_Homo sapiens_hsa043700.66184978
56HTLV-I infection_Homo sapiens_hsa051660.64480629
57FoxO signaling pathway_Homo sapiens_hsa040680.62992265
58Arachidonic acid metabolism_Homo sapiens_hsa005900.62755894
59Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62448136
60Glycerophospholipid metabolism_Homo sapiens_hsa005640.60032380
61Salmonella infection_Homo sapiens_hsa051320.59877008
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56424031
63Hepatitis B_Homo sapiens_hsa051610.56140289
64Olfactory transduction_Homo sapiens_hsa047400.54493871
65Ras signaling pathway_Homo sapiens_hsa040140.54119703
66Rap1 signaling pathway_Homo sapiens_hsa040150.53788456
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.53702500
68Chronic myeloid leukemia_Homo sapiens_hsa052200.52826375
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50905156
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49869453
71Prion diseases_Homo sapiens_hsa050200.45728077
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45384558
73Epstein-Barr virus infection_Homo sapiens_hsa051690.44161346
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44014729
75Long-term potentiation_Homo sapiens_hsa047200.42876085
76Ether lipid metabolism_Homo sapiens_hsa005650.42020659
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.41896052
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.41475156
79Regulation of autophagy_Homo sapiens_hsa041400.41405233
80Type II diabetes mellitus_Homo sapiens_hsa049300.40979606
81Endocytosis_Homo sapiens_hsa041440.40335658
82MAPK signaling pathway_Homo sapiens_hsa040100.39714413
83Choline metabolism in cancer_Homo sapiens_hsa052310.38442254
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35858239
85Renal cell carcinoma_Homo sapiens_hsa052110.35708583
86Colorectal cancer_Homo sapiens_hsa052100.34861917
87Lysosome_Homo sapiens_hsa041420.33840283
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32581661
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32560599
90Prolactin signaling pathway_Homo sapiens_hsa049170.32227851
91Systemic lupus erythematosus_Homo sapiens_hsa053220.29957817
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.28956640
93Dorso-ventral axis formation_Homo sapiens_hsa043200.28668446
94Inositol phosphate metabolism_Homo sapiens_hsa005620.28621484
95Insulin resistance_Homo sapiens_hsa049310.27946502
96Collecting duct acid secretion_Homo sapiens_hsa049660.27505417
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27120434
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.26065297
99Complement and coagulation cascades_Homo sapiens_hsa046100.21784135
100Amoebiasis_Homo sapiens_hsa051460.20018737

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