

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | lateral sprouting from an epithelium (GO:0060601) | 9.22460489 |
| 2 | positive regulation of astrocyte differentiation (GO:0048711) | 8.52944456 |
| 3 | innervation (GO:0060384) | 7.92110160 |
| 4 | negative regulation of sodium ion transport (GO:0010766) | 7.82418171 |
| 5 | regulation of timing of cell differentiation (GO:0048505) | 7.51429684 |
| 6 | regulation of development, heterochronic (GO:0040034) | 7.11789152 |
| 7 | negative regulation of homotypic cell-cell adhesion (GO:0034111) | 6.93359233 |
| 8 | establishment of nucleus localization (GO:0040023) | 6.71224028 |
| 9 | regulation of plasminogen activation (GO:0010755) | 6.34680021 |
| 10 | glomerular filtration (GO:0003094) | 6.11430266 |
| 11 | prepulse inhibition (GO:0060134) | 6.04791439 |
| 12 | establishment of tissue polarity (GO:0007164) | 5.72980594 |
| 13 | establishment of planar polarity (GO:0001736) | 5.72980594 |
| 14 | negative regulation of axon extension (GO:0030517) | 5.61075329 |
| 15 | planar cell polarity pathway involved in neural tube closure (GO:0090179) | 5.57333820 |
| 16 | presynaptic membrane assembly (GO:0097105) | 5.53095422 |
| 17 | negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067) | 5.51288755 |
| 18 | regulation of astrocyte differentiation (GO:0048710) | 5.33402819 |
| 19 | renal filtration (GO:0097205) | 5.28080175 |
| 20 | primitive streak formation (GO:0090009) | 5.18088950 |
| 21 | secretory granule organization (GO:0033363) | 5.15464348 |
| 22 | cell proliferation in forebrain (GO:0021846) | 5.14569042 |
| 23 | regulation of establishment of planar polarity involved in neural tube closure (GO:0090178) | 5.07354755 |
| 24 | negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037) | 4.95861072 |
| 25 | glomerular basement membrane development (GO:0032836) | 4.80943608 |
| 26 | negative regulation of mesenchymal cell apoptotic process (GO:2001054) | 4.76533621 |
| 27 | presynaptic membrane organization (GO:0097090) | 4.73066997 |
| 28 | dendritic spine morphogenesis (GO:0060997) | 4.72493116 |
| 29 | cochlea morphogenesis (GO:0090103) | 4.66684484 |
| 30 | midgut development (GO:0007494) | 4.54829076 |
| 31 | regulation of platelet aggregation (GO:0090330) | 4.48370041 |
| 32 | axon ensheathment in central nervous system (GO:0032291) | 4.41884958 |
| 33 | central nervous system myelination (GO:0022010) | 4.41884958 |
| 34 | otic vesicle formation (GO:0030916) | 4.32085933 |
| 35 | regulation of synapse structural plasticity (GO:0051823) | 4.26180536 |
| 36 | limb bud formation (GO:0060174) | 4.26095345 |
| 37 | positive regulation of glial cell differentiation (GO:0045687) | 4.17201518 |
| 38 | negative regulation of axon extension involved in axon guidance (GO:0048843) | 4.08349795 |
| 39 | negative regulation of oligodendrocyte differentiation (GO:0048715) | 4.07651849 |
| 40 | radial glial cell differentiation (GO:0060019) | 4.06926150 |
| 41 | pattern specification involved in kidney development (GO:0061004) | 4.05066531 |
| 42 | tongue development (GO:0043586) | 4.01541674 |
| 43 | chondroitin sulfate catabolic process (GO:0030207) | 4.00602263 |
| 44 | mesenchymal-epithelial cell signaling (GO:0060638) | 3.93786153 |
| 45 | neuronal stem cell maintenance (GO:0097150) | 3.93753928 |
| 46 | nonmotile primary cilium assembly (GO:0035058) | 3.90974486 |
| 47 | dopaminergic neuron differentiation (GO:0071542) | 3.88342740 |
| 48 | negative regulation of astrocyte differentiation (GO:0048712) | 3.83566777 |
| 49 | regulation of mesenchymal cell apoptotic process (GO:2001053) | 3.82416996 |
| 50 | viral transcription (GO:0019083) | 3.80356382 |
| 51 | negative regulation of axon guidance (GO:1902668) | 3.80280035 |
| 52 | cellular response to electrical stimulus (GO:0071257) | 3.78734057 |
| 53 | negative regulation of smoothened signaling pathway (GO:0045879) | 3.78026280 |
| 54 | cell surface receptor signaling pathway involved in heart development (GO:0061311) | 3.70574187 |
| 55 | forebrain neuron differentiation (GO:0021879) | 3.67405082 |
| 56 | convergent extension (GO:0060026) | 3.61237989 |
| 57 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.59669311 |
| 58 | translational termination (GO:0006415) | 3.58464602 |
| 59 | forebrain neuron development (GO:0021884) | 3.58143689 |
| 60 | neuron fate determination (GO:0048664) | 3.57524490 |
| 61 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 3.57153413 |
| 62 | heart valve formation (GO:0003188) | 3.56945582 |
| 63 | negative regulation of axonogenesis (GO:0050771) | 3.54244495 |
| 64 | nucleus localization (GO:0051647) | 3.52961670 |
| 65 | Wnt signaling pathway, planar cell polarity pathway (GO:0060071) | 3.49713091 |
| 66 | lens fiber cell development (GO:0070307) | 3.42442955 |
| 67 | notochord development (GO:0030903) | 3.40066469 |
| 68 | positive regulation of interleukin-8 secretion (GO:2000484) | 3.39959526 |
| 69 | paraxial mesoderm development (GO:0048339) | 3.39315264 |
| 70 | negative regulation of platelet activation (GO:0010544) | 3.38395461 |
| 71 | cranial nerve morphogenesis (GO:0021602) | 3.35624119 |
| 72 | G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199 | 3.34686009 |
| 73 | regulation of glial cell differentiation (GO:0045685) | 3.34100424 |
| 74 | chondrocyte development (GO:0002063) | 3.33461750 |
| 75 | retinal ganglion cell axon guidance (GO:0031290) | 3.33344963 |
| 76 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.32379102 |
| 77 | postsynaptic membrane organization (GO:0001941) | 3.32048065 |
| 78 | regulation of cell-cell adhesion mediated by cadherin (GO:2000047) | 3.30205784 |
| 79 | regulation of establishment of planar polarity (GO:0090175) | 3.28318039 |
| 80 | neuron cell-cell adhesion (GO:0007158) | 3.28290821 |
| 81 | astrocyte differentiation (GO:0048708) | 3.26665594 |
| 82 | Notch signaling involved in heart development (GO:0061314) | 3.25548002 |
| 83 | positive regulation of synapse assembly (GO:0051965) | 3.24305208 |
| 84 | nucleobase catabolic process (GO:0046113) | 3.20238541 |
| 85 | somite development (GO:0061053) | 3.15220961 |
| 86 | negative regulation of glial cell differentiation (GO:0045686) | 3.14323321 |
| 87 | central nervous system projection neuron axonogenesis (GO:0021952) | 3.14224235 |
| 88 | face development (GO:0060324) | 3.11360717 |
| 89 | regulation of somitogenesis (GO:0014807) | 3.10932574 |
| 90 | cranial nerve development (GO:0021545) | 3.10760398 |
| 91 | response to auditory stimulus (GO:0010996) | 3.10385539 |
| 92 | positive regulation of protein kinase C signaling (GO:0090037) | 3.09765841 |
| 93 | retinal rod cell development (GO:0046548) | 3.08053766 |
| 94 | detection of mechanical stimulus involved in sensory perception (GO:0050974) | 3.05613597 |
| 95 | cellular response to cholesterol (GO:0071397) | 3.05337809 |
| 96 | pyrimidine nucleobase catabolic process (GO:0006208) | 3.05313482 |
| 97 | regulation of oligodendrocyte differentiation (GO:0048713) | 3.04765752 |
| 98 | outer ear morphogenesis (GO:0042473) | 3.04179771 |
| 99 | lipopolysaccharide biosynthetic process (GO:0009103) | 3.03196668 |
| 100 | neural precursor cell proliferation (GO:0061351) | 3.02472882 |
| 101 | endocardial cushion morphogenesis (GO:0003203) | 3.01708898 |
| 102 | regulation of homotypic cell-cell adhesion (GO:0034110) | 3.01063403 |
| 103 | cell-cell signaling involved in cell fate commitment (GO:0045168) | 3.00041123 |
| 104 | cotranslational protein targeting to membrane (GO:0006613) | 2.99811061 |
| 105 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 2.99669944 |
| 106 | L-serine metabolic process (GO:0006563) | 2.97276782 |
| 107 | axonal fasciculation (GO:0007413) | 2.96939345 |
| 108 | negative regulation of developmental growth (GO:0048640) | 2.96273767 |
| 109 | inner ear morphogenesis (GO:0042472) | 2.96176164 |
| 110 | * regulation of fibroblast growth factor receptor signaling pathway (GO:0040036) | 2.96097529 |
| 111 | negative chemotaxis (GO:0050919) | 2.94598091 |
| 112 | protein targeting to ER (GO:0045047) | 2.94342018 |
| 113 | cholesterol biosynthetic process (GO:0006695) | 2.94157978 |
| 114 | cerebral cortex radially oriented cell migration (GO:0021799) | 2.94044722 |
| 115 | spinal cord development (GO:0021510) | 2.93880976 |
| 116 | vocalization behavior (GO:0071625) | 2.90675759 |
| 117 | midbrain development (GO:0030901) | 2.89950422 |
| 118 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 2.89211543 |
| 119 | urogenital system development (GO:0001655) | 2.89136378 |
| 120 | limb development (GO:0060173) | 2.88850388 |
| 121 | appendage development (GO:0048736) | 2.88850388 |
| 122 | epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198) | 2.88593225 |
| 123 | central nervous system neuron development (GO:0021954) | 2.87420731 |
| 124 | cell migration in hindbrain (GO:0021535) | 2.87301182 |
| 125 | regulation of axon extension involved in axon guidance (GO:0048841) | 2.86556523 |
| 126 | behavioral response to nicotine (GO:0035095) | 2.85815051 |
| 127 | positive regulation of gliogenesis (GO:0014015) | 2.83761180 |
| 128 | regulation of axon guidance (GO:1902667) | 2.82722357 |
| 129 | epithelial cilium movement (GO:0003351) | 2.81857135 |
| 130 | cellular response to sterol (GO:0036315) | 2.81113987 |
| 131 | positive regulation of Notch signaling pathway (GO:0045747) | 2.79624383 |
| 132 | somatic stem cell division (GO:0048103) | 2.78276326 |
| 133 | segment specification (GO:0007379) | 2.76103074 |
| 134 | pituitary gland development (GO:0021983) | 2.73770931 |
| 135 | regulation of penile erection (GO:0060405) | 2.72693061 |
| 136 | negative regulation of gliogenesis (GO:0014014) | 2.72205458 |
| 137 | developmental induction (GO:0031128) | 2.70763581 |
| 138 | chromatin remodeling at centromere (GO:0031055) | 2.69931825 |
| 139 | sterol biosynthetic process (GO:0016126) | 2.69511644 |
| 140 | smoothened signaling pathway (GO:0007224) | 2.68490986 |
| 141 | nephron tubule morphogenesis (GO:0072078) | 2.67520352 |
| 142 | nephron epithelium morphogenesis (GO:0072088) | 2.67520352 |
| 143 | detection of mechanical stimulus involved in sensory perception of sound (GO:0050910) | 2.66676641 |
| 144 | somatic stem cell maintenance (GO:0035019) | 2.63950822 |
| 145 | regulation of non-canonical Wnt signaling pathway (GO:2000050) | 2.63903365 |
| 146 | hindbrain development (GO:0030902) | 2.63866670 |
| 147 | post-anal tail morphogenesis (GO:0036342) | 2.62904873 |
| 148 | cilium movement (GO:0003341) | 2.62819313 |
| 149 | lung-associated mesenchyme development (GO:0060484) | 2.61472897 |
| 150 | negative regulation of hematopoietic progenitor cell differentiation (GO:1901533) | 2.60842549 |
| 151 | regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095) | 2.59027502 |
| 152 | intraciliary transport (GO:0042073) | 2.58339834 |
| 153 | mechanoreceptor differentiation (GO:0042490) | 2.53868735 |
| 154 | positive regulation of neuroblast proliferation (GO:0002052) | 2.53747009 |
| 155 | digestive tract morphogenesis (GO:0048546) | 2.50919575 |
| 156 | neuron recognition (GO:0008038) | 2.50775867 |
| 157 | mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337) | 2.50372493 |
| 158 | dorsal/ventral axis specification (GO:0009950) | 2.49396036 |
| 159 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339) | 2.49334654 |
| 160 | CENP-A containing nucleosome assembly (GO:0034080) | 2.46030357 |
| 161 | axonemal dynein complex assembly (GO:0070286) | 2.44827729 |
| 162 | mesenchymal to epithelial transition (GO:0060231) | 2.44601616 |
| 163 | cochlea development (GO:0090102) | 2.44024880 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 6.01702714 |
| 2 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 3.97205404 |
| 3 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 3.82790622 |
| 4 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 3.66970077 |
| 5 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 3.59607064 |
| 6 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 3.46291672 |
| 7 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 3.44949989 |
| 8 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 3.39475859 |
| 9 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 3.36324181 |
| 10 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 3.31921716 |
| 11 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 3.19708858 |
| 12 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 3.17604969 |
| 13 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 3.00026201 |
| 14 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.94070786 |
| 15 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.92825898 |
| 16 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.92825898 |
| 17 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.89890355 |
| 18 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 2.88200436 |
| 19 | * SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.78137966 |
| 20 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.77056628 |
| 21 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.68034054 |
| 22 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.64813424 |
| 23 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.59106500 |
| 24 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 2.56411468 |
| 25 | * MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.38145409 |
| 26 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 2.35645355 |
| 27 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 2.24779654 |
| 28 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 2.19964243 |
| 29 | AR_21572438_ChIP-Seq_LNCaP_Human | 2.17003524 |
| 30 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.13808015 |
| 31 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 2.11411103 |
| 32 | * RING1B_27294783_Chip-Seq_NPCs_Mouse | 2.08272860 |
| 33 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.06227329 |
| 34 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.02337320 |
| 35 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.98684547 |
| 36 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.88980614 |
| 37 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.85968545 |
| 38 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.85732250 |
| 39 | EWS_26573619_Chip-Seq_HEK293_Human | 1.82638900 |
| 40 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.80608274 |
| 41 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.75852234 |
| 42 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.73639948 |
| 43 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.65883248 |
| 44 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.63576418 |
| 45 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.62833526 |
| 46 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.62493253 |
| 47 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.58935089 |
| 48 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.57659615 |
| 49 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.55642031 |
| 50 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.50855789 |
| 51 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.43282972 |
| 52 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.43282972 |
| 53 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.43282972 |
| 54 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.42596223 |
| 55 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.41052587 |
| 56 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.40592868 |
| 57 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.39702194 |
| 58 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.39478402 |
| 59 | POU5F1_18347094_ChIP-ChIP_MESCs_Mouse | 1.37634463 |
| 60 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.37537676 |
| 61 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.37313639 |
| 62 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.36212910 |
| 63 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.36040892 |
| 64 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.35175894 |
| 65 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.34962025 |
| 66 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.32933299 |
| 67 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.31806722 |
| 68 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.29945169 |
| 69 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.29885780 |
| 70 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 1.29796181 |
| 71 | SOX9_26525672_Chip-Seq_HEART_Mouse | 1.28842236 |
| 72 | SOX2_18358816_ChIP-ChIP_MESCs_Mouse | 1.27249750 |
| 73 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.26670737 |
| 74 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.25942809 |
| 75 | STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 1.23631115 |
| 76 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.22435623 |
| 77 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.21677337 |
| 78 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.20427657 |
| 79 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.18394577 |
| 80 | VDR_22108803_ChIP-Seq_LS180_Human | 1.18224012 |
| 81 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.16444832 |
| 82 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.15819479 |
| 83 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.13018227 |
| 84 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.12324797 |
| 85 | * BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.12043986 |
| 86 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.11293896 |
| 87 | P300_19829295_ChIP-Seq_ESCs_Human | 1.10965777 |
| 88 | SOX3_22085726_ChIP-Seq_NPCs_Mouse | 1.10246195 |
| 89 | TCF3_18692474_ChIP-Seq_MESCs_Mouse | 1.09984112 |
| 90 | FUS_26573619_Chip-Seq_HEK293_Human | 1.09239307 |
| 91 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.08942324 |
| 92 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.08283628 |
| 93 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.07209906 |
| 94 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.05976032 |
| 95 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.05174188 |
| 96 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.04546666 |
| 97 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.03055012 |
| 98 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.03001911 |
| 99 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 1.01703413 |
| 100 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.01138577 |
| 101 | NANOG_18347094_ChIP-ChIP_MESCs_Mouse | 1.00409643 |
| 102 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.99366764 |
| 103 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.99223089 |
| 104 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 0.98498779 |
| 105 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 0.98233717 |
| 106 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.98095889 |
| 107 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.97121196 |
| 108 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.97121196 |
| 109 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.95979603 |
| 110 | MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse | 0.95592846 |
| 111 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.95359607 |
| 112 | CLOCK_20551151_ChIP-Seq_293T_Human | 0.94397980 |
| 113 | RNF2_27304074_Chip-Seq_NSC_Mouse | 0.92526765 |
| 114 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.90525935 |
| 115 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.90399347 |
| 116 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 0.89854449 |
| 117 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.89783794 |
| 118 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.89144086 |
| 119 | * CTCF_27219007_Chip-Seq_Bcells_Human | 0.86778728 |
| 120 | TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 0.86647071 |
| 121 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.85818601 |
| 122 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.85471257 |
| 123 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.84746005 |
| 124 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.84291750 |
| 125 | TBX3_20139965_ChIP-Seq_MESCs_Mouse | 0.83637033 |
| 126 | TBX3_20139965_ChIP-Seq_ESCs_Mouse | 0.83051263 |
| 127 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 0.82497842 |
| 128 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.82115959 |
| 129 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 0.81834988 |
| 130 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 0.81087678 |
| 131 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 0.80980351 |
| 132 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 0.78685960 |
| 133 | AR_19668381_ChIP-Seq_PC3_Human | 0.78215954 |
| 134 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 0.78045875 |
| 135 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.77841638 |
| 136 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.77413108 |
| 137 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 0.77068739 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004858_abnormal_nervous_system | 5.99005959 |
| 2 | MP0003136_yellow_coat_color | 4.26487086 |
| 3 | MP0000778_abnormal_nervous_system | 4.12840940 |
| 4 | MP0001529_abnormal_vocalization | 3.03595537 |
| 5 | MP0000566_synostosis | 2.97104858 |
| 6 | MP0004885_abnormal_endolymph | 2.77280908 |
| 7 | MP0002282_abnormal_trachea_morphology | 2.73080593 |
| 8 | MP0009053_abnormal_anal_canal | 2.66005320 |
| 9 | MP0001485_abnormal_pinna_reflex | 2.48926832 |
| 10 | MP0000537_abnormal_urethra_morphology | 2.47619033 |
| 11 | MP0003283_abnormal_digestive_organ | 2.44812488 |
| 12 | MP0004742_abnormal_vestibular_system | 2.36803985 |
| 13 | MP0005377_hearing/vestibular/ear_phenot | 2.29623112 |
| 14 | MP0003878_abnormal_ear_physiology | 2.29623112 |
| 15 | MP0009379_abnormal_foot_pigmentation | 2.24670423 |
| 16 | MP0002751_abnormal_autonomic_nervous | 2.22668465 |
| 17 | MP0003938_abnormal_ear_development | 2.19603439 |
| 18 | MP0002102_abnormal_ear_morphology | 2.18748441 |
| 19 | MP0003635_abnormal_synaptic_transmissio | 2.17610142 |
| 20 | MP0004859_abnormal_synaptic_plasticity | 2.13820725 |
| 21 | MP0005423_abnormal_somatic_nervous | 2.11936459 |
| 22 | MP0000026_abnormal_inner_ear | 2.07050035 |
| 23 | MP0002736_abnormal_nociception_after | 2.03453317 |
| 24 | MP0000049_abnormal_middle_ear | 2.02830793 |
| 25 | MP0002277_abnormal_respiratory_mucosa | 1.87670784 |
| 26 | MP0002067_abnormal_sensory_capabilities | 1.74121976 |
| 27 | MP0001968_abnormal_touch/_nociception | 1.69224297 |
| 28 | MP0002932_abnormal_joint_morphology | 1.66242484 |
| 29 | MP0002557_abnormal_social/conspecific_i | 1.62105405 |
| 30 | MP0009745_abnormal_behavioral_response | 1.61886040 |
| 31 | MP0003121_genomic_imprinting | 1.61637771 |
| 32 | MP0004133_heterotaxia | 1.58268764 |
| 33 | MP0005174_abnormal_tail_pigmentation | 1.56217789 |
| 34 | MP0006292_abnormal_olfactory_placode | 1.55442589 |
| 35 | MP0000467_abnormal_esophagus_morphology | 1.54539231 |
| 36 | MP0002063_abnormal_learning/memory/cond | 1.54181336 |
| 37 | MP0000955_abnormal_spinal_cord | 1.50530083 |
| 38 | MP0003634_abnormal_glial_cell | 1.50368750 |
| 39 | MP0000462_abnormal_digestive_system | 1.49115246 |
| 40 | MP0002938_white_spotting | 1.48665041 |
| 41 | MP0006072_abnormal_retinal_apoptosis | 1.48068982 |
| 42 | MP0002234_abnormal_pharynx_morphology | 1.48037126 |
| 43 | MP0002572_abnormal_emotion/affect_behav | 1.47100335 |
| 44 | MP0003937_abnormal_limbs/digits/tail_de | 1.43467276 |
| 45 | MP0002152_abnormal_brain_morphology | 1.42102541 |
| 46 | MP0003315_abnormal_perineum_morphology | 1.40088641 |
| 47 | MP0003861_abnormal_nervous_system | 1.39071285 |
| 48 | MP0003011_delayed_dark_adaptation | 1.38679356 |
| 49 | MP0005171_absent_coat_pigmentation | 1.38334522 |
| 50 | MP0000631_abnormal_neuroendocrine_gland | 1.36465375 |
| 51 | MP0001984_abnormal_olfaction | 1.35457556 |
| 52 | MP0002064_seizures | 1.35322943 |
| 53 | MP0008789_abnormal_olfactory_epithelium | 1.29332377 |
| 54 | MP0010030_abnormal_orbit_morphology | 1.29296959 |
| 55 | MP0002653_abnormal_ependyma_morphology | 1.28574692 |
| 56 | MP0005187_abnormal_penis_morphology | 1.28534174 |
| 57 | MP0003942_abnormal_urinary_system | 1.28010386 |
| 58 | MP0005248_abnormal_Harderian_gland | 1.26397747 |
| 59 | MP0002272_abnormal_nervous_system | 1.19272932 |
| 60 | MP0002092_abnormal_eye_morphology | 1.17242682 |
| 61 | MP0002697_abnormal_eye_size | 1.15840864 |
| 62 | MP0003115_abnormal_respiratory_system | 1.15528331 |
| 63 | MP0001293_anophthalmia | 1.14649567 |
| 64 | MP0001486_abnormal_startle_reflex | 1.13712175 |
| 65 | MP0003122_maternal_imprinting | 1.13397956 |
| 66 | MP0001963_abnormal_hearing_physiology | 1.12956090 |
| 67 | MP0003787_abnormal_imprinting | 1.12030056 |
| 68 | MP0003880_abnormal_central_pattern | 1.11908702 |
| 69 | MP0001286_abnormal_eye_development | 1.11010098 |
| 70 | MP0008932_abnormal_embryonic_tissue | 1.10594647 |
| 71 | MP0008877_abnormal_DNA_methylation | 1.10420629 |
| 72 | MP0003890_abnormal_embryonic-extraembry | 1.09939268 |
| 73 | MP0000428_abnormal_craniofacial_morphol | 1.09452292 |
| 74 | MP0002752_abnormal_somatic_nervous | 1.05165196 |
| 75 | MP0002882_abnormal_neuron_morphology | 1.03899755 |
| 76 | MP0003385_abnormal_body_wall | 1.03483532 |
| 77 | MP0002116_abnormal_craniofacial_bone | 1.03391854 |
| 78 | MP0003941_abnormal_skin_development | 1.01413668 |
| 79 | MP0002734_abnormal_mechanical_nocicepti | 0.99865550 |
| 80 | MP0001346_abnormal_lacrimal_gland | 0.99560031 |
| 81 | MP0005394_taste/olfaction_phenotype | 0.99044565 |
| 82 | MP0005499_abnormal_olfactory_system | 0.99044565 |
| 83 | MP0002098_abnormal_vibrissa_morphology | 0.96531858 |
| 84 | MP0002638_abnormal_pupillary_reflex | 0.96343733 |
| 85 | MP0002249_abnormal_larynx_morphology | 0.95399624 |
| 86 | MP0001502_abnormal_circadian_rhythm | 0.95187508 |
| 87 | MP0003183_abnormal_peptide_metabolism | 0.94625759 |
| 88 | MP0000383_abnormal_hair_follicle | 0.94603079 |
| 89 | MP0004270_analgesia | 0.94046182 |
| 90 | MP0003119_abnormal_digestive_system | 0.91841406 |
| 91 | MP0002184_abnormal_innervation | 0.91643013 |
| 92 | MP0005195_abnormal_posterior_eye | 0.91234384 |
| 93 | MP0002089_abnormal_postnatal_growth/wei | 0.89122060 |
| 94 | MP0002233_abnormal_nose_morphology | 0.88453249 |
| 95 | MP0000534_abnormal_ureter_morphology | 0.87231451 |
| 96 | MP0000762_abnormal_tongue_morphology | 0.86806300 |
| 97 | MP0000579_abnormal_nail_morphology | 0.86323709 |
| 98 | MP0002735_abnormal_chemical_nociception | 0.85424931 |
| 99 | MP0001958_emphysema | 0.85073702 |
| 100 | MP0009250_abnormal_appendicular_skeleto | 0.85026557 |
| 101 | MP0005623_abnormal_meninges_morphology | 0.83721784 |
| 102 | MP0002066_abnormal_motor_capabilities/c | 0.83440936 |
| 103 | MP0002733_abnormal_thermal_nociception | 0.83280810 |
| 104 | MP0005551_abnormal_eye_electrophysiolog | 0.83051638 |
| 105 | MP0008058_abnormal_DNA_repair | 0.83043978 |
| 106 | MP0001177_atelectasis | 0.82184377 |
| 107 | MP0002095_abnormal_skin_pigmentation | 0.81946175 |
| 108 | MP0004142_abnormal_muscle_tone | 0.81413307 |
| 109 | MP0006276_abnormal_autonomic_nervous | 0.80906248 |
| 110 | MP0000432_abnormal_head_morphology | 0.79583932 |
| 111 | MP0003935_abnormal_craniofacial_develop | 0.78963397 |
| 112 | MP0005381_digestive/alimentary_phenotyp | 0.77502649 |
| 113 | MP0002928_abnormal_bile_duct | 0.76984100 |
| 114 | MP0001970_abnormal_pain_threshold | 0.76163535 |
| 115 | MP0000647_abnormal_sebaceous_gland | 0.76039907 |
| 116 | MP0005253_abnormal_eye_physiology | 0.74903307 |
| 117 | MP0001340_abnormal_eyelid_morphology | 0.73160600 |
| 118 | MP0002177_abnormal_outer_ear | 0.73080801 |
| 119 | MP0002111_abnormal_tail_morphology | 0.73031002 |
| 120 | MP0005391_vision/eye_phenotype | 0.70649547 |
| 121 | MP0003755_abnormal_palate_morphology | 0.70637545 |
| 122 | MP0002081_perinatal_lethality | 0.70053530 |
| 123 | MP0004147_increased_porphyrin_level | 0.69985503 |
| 124 | MP0001943_abnormal_respiration | 0.67718891 |
| 125 | MP0001299_abnormal_eye_distance/ | 0.67675947 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Morphological abnormality of the middle ear (HP:0008609) | 5.96473191 |
| 2 | Bifid tongue (HP:0010297) | 5.14944977 |
| 3 | Short middle phalanx of the 5th finger (HP:0004220) | 4.71464148 |
| 4 | Coronal craniosynostosis (HP:0004440) | 4.52170056 |
| 5 | Morphological abnormality of the inner ear (HP:0011390) | 4.10577987 |
| 6 | Bilateral microphthalmos (HP:0007633) | 4.09446481 |
| 7 | Abnormality of the right ventricle (HP:0001707) | 3.89884474 |
| 8 | Reticulocytopenia (HP:0001896) | 3.76035108 |
| 9 | Maternal diabetes (HP:0009800) | 3.72091338 |
| 10 | Septo-optic dysplasia (HP:0100842) | 3.67569336 |
| 11 | Anophthalmia (HP:0000528) | 3.63438719 |
| 12 | Abnormality of the 4th metacarpal (HP:0010012) | 3.44849054 |
| 13 | True hermaphroditism (HP:0010459) | 3.31809881 |
| 14 | Myokymia (HP:0002411) | 3.17292892 |
| 15 | Optic nerve hypoplasia (HP:0000609) | 3.12777461 |
| 16 | Rib fusion (HP:0000902) | 3.09694011 |
| 17 | Gastrointestinal atresia (HP:0002589) | 3.08012418 |
| 18 | Tarsal synostosis (HP:0008368) | 3.06493962 |
| 19 | Midline defect of the nose (HP:0004122) | 3.03917118 |
| 20 | Abnormality of the labia minora (HP:0012880) | 3.03525011 |
| 21 | Hemivertebrae (HP:0002937) | 2.99774379 |
| 22 | Supernumerary ribs (HP:0005815) | 2.98531749 |
| 23 | Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161) | 2.98513467 |
| 24 | Myelomeningocele (HP:0002475) | 2.93384195 |
| 25 | Megalencephaly (HP:0001355) | 2.92710752 |
| 26 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.89778390 |
| 27 | Synostosis involving bones of the feet (HP:0009140) | 2.89592426 |
| 28 | Synostosis involving bones of the lower limbs (HP:0009138) | 2.89592426 |
| 29 | Increased number of teeth (HP:0011069) | 2.87128768 |
| 30 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 2.86311549 |
| 31 | Supernumerary bones of the axial skeleton (HP:0009144) | 2.84959432 |
| 32 | Missing ribs (HP:0000921) | 2.78015605 |
| 33 | Abnormal number of incisors (HP:0011064) | 2.77386833 |
| 34 | Synostosis of carpal bones (HP:0005048) | 2.75935338 |
| 35 | Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376) | 2.75629918 |
| 36 | Down-sloping shoulders (HP:0200021) | 2.72255400 |
| 37 | Neonatal short-limb short stature (HP:0008921) | 2.72235314 |
| 38 | Parakeratosis (HP:0001036) | 2.69290331 |
| 39 | Colon cancer (HP:0003003) | 2.69118168 |
| 40 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 2.68445029 |
| 41 | Bronchomalacia (HP:0002780) | 2.67565622 |
| 42 | Fibular hypoplasia (HP:0003038) | 2.66523782 |
| 43 | Long palpebral fissure (HP:0000637) | 2.64579737 |
| 44 | Abnormality of the middle phalanx of the 5th finger (HP:0004219) | 2.59074843 |
| 45 | Cortical dysplasia (HP:0002539) | 2.58582729 |
| 46 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 2.57873003 |
| 47 | Short 4th metacarpal (HP:0010044) | 2.57873003 |
| 48 | Split foot (HP:0001839) | 2.57654727 |
| 49 | Renal duplication (HP:0000075) | 2.57384605 |
| 50 | Progressive sensorineural hearing impairment (HP:0000408) | 2.55253836 |
| 51 | Facial hemangioma (HP:0000329) | 2.54079923 |
| 52 | Pancreatic fibrosis (HP:0100732) | 2.53573184 |
| 53 | Abnormal number of erythroid precursors (HP:0012131) | 2.48617282 |
| 54 | Mesomelia (HP:0003027) | 2.47801882 |
| 55 | Abnormality of the phalanges of the 5th finger (HP:0004213) | 2.42277417 |
| 56 | Macrocytic anemia (HP:0001972) | 2.40318712 |
| 57 | Aplasia involving bones of the extremities (HP:0009825) | 2.40021767 |
| 58 | Aplasia involving bones of the upper limbs (HP:0009823) | 2.40021767 |
| 59 | Aplasia of the phalanges of the hand (HP:0009802) | 2.40021767 |
| 60 | Large earlobe (HP:0009748) | 2.39464451 |
| 61 | Trigonocephaly (HP:0000243) | 2.39405269 |
| 62 | Choanal stenosis (HP:0000452) | 2.39005646 |
| 63 | Supranuclear gaze palsy (HP:0000605) | 2.33496051 |
| 64 | Hepatoblastoma (HP:0002884) | 2.31440803 |
| 65 | Abnormality of the middle phalanges of the toes (HP:0010183) | 2.31061361 |
| 66 | Sclerocornea (HP:0000647) | 2.30023792 |
| 67 | Anosmia (HP:0000458) | 2.28033637 |
| 68 | High anterior hairline (HP:0009890) | 2.25774644 |
| 69 | Sex reversal (HP:0012245) | 2.23902339 |
| 70 | Abnormal sex determination (HP:0012244) | 2.23902339 |
| 71 | Oligodactyly (HP:0012165) | 2.23822557 |
| 72 | Hyperglycinemia (HP:0002154) | 2.23812651 |
| 73 | Porencephaly (HP:0002132) | 2.23653412 |
| 74 | Oligodactyly (hands) (HP:0001180) | 2.23446127 |
| 75 | Intestinal atresia (HP:0011100) | 2.23277379 |
| 76 | Agitation (HP:0000713) | 2.22589072 |
| 77 | Hypoplastic labia majora (HP:0000059) | 2.21187622 |
| 78 | 11 pairs of ribs (HP:0000878) | 2.17962941 |
| 79 | Partial duplication of thumb phalanx (HP:0009944) | 2.15908553 |
| 80 | Nephronophthisis (HP:0000090) | 2.13707265 |
| 81 | Esotropia (HP:0000565) | 2.12762261 |
| 82 | Glossoptosis (HP:0000162) | 2.12149530 |
| 83 | Molar tooth sign on MRI (HP:0002419) | 2.11449852 |
| 84 | Abnormality of midbrain morphology (HP:0002418) | 2.11449852 |
| 85 | Dysdiadochokinesis (HP:0002075) | 2.11067708 |
| 86 | Pancreatic cysts (HP:0001737) | 2.10656423 |
| 87 | Holoprosencephaly (HP:0001360) | 2.08050753 |
| 88 | Skull defect (HP:0001362) | 2.07658025 |
| 89 | Preaxial foot polydactyly (HP:0001841) | 2.07148293 |
| 90 | Carpal synostosis (HP:0009702) | 2.07052899 |
| 91 | Pallor (HP:0000980) | 2.06944120 |
| 92 | Vaginal atresia (HP:0000148) | 2.05726990 |
| 93 | Large for gestational age (HP:0001520) | 2.05266165 |
| 94 | Gait imbalance (HP:0002141) | 2.05239785 |
| 95 | Progressive cerebellar ataxia (HP:0002073) | 2.05151639 |
| 96 | Medial flaring of the eyebrow (HP:0010747) | 2.05133216 |
| 97 | Genital tract atresia (HP:0001827) | 2.05060601 |
| 98 | Focal motor seizures (HP:0011153) | 2.04869465 |
| 99 | Broad toe (HP:0001837) | 2.04314935 |
| 100 | Cutaneous finger syndactyly (HP:0010554) | 2.04045921 |
| 101 | Dental crowding (HP:0000678) | 2.03702981 |
| 102 | Vertebral clefting (HP:0008428) | 2.02797194 |
| 103 | Short 5th finger (HP:0009237) | 2.02425405 |
| 104 | Wide anterior fontanel (HP:0000260) | 2.01611287 |
| 105 | Meningocele (HP:0002435) | 2.01180584 |
| 106 | Aplasia/Hypoplasia of the 5th finger (HP:0006262) | 2.01160017 |
| 107 | Short middle phalanx of finger (HP:0005819) | 2.00978057 |
| 108 | Neurofibrillary tangles (HP:0002185) | 2.00882701 |
| 109 | Shallow orbits (HP:0000586) | 2.00329311 |
| 110 | Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843) | 1.99971134 |
| 111 | Absent septum pellucidum (HP:0001331) | 1.99551874 |
| 112 | Congenital primary aphakia (HP:0007707) | 1.98496514 |
| 113 | Delayed CNS myelination (HP:0002188) | 1.97533868 |
| 114 | Abnormality of the parietal bone (HP:0002696) | 1.96979349 |
| 115 | Postaxial hand polydactyly (HP:0001162) | 1.96856372 |
| 116 | Adactyly (HP:0009776) | 1.96410778 |
| 117 | Anencephaly (HP:0002323) | 1.96159968 |
| 118 | Hypoplastic pelvis (HP:0008839) | 1.94997058 |
| 119 | Hemiparesis (HP:0001269) | 1.94863968 |
| 120 | Polyphagia (HP:0002591) | 1.94194576 |
| 121 | Supernumerary spleens (HP:0009799) | 1.94022934 |
| 122 | Abnormality of the labia majora (HP:0012881) | 1.93735218 |
| 123 | Abnormality of the diencephalon (HP:0010662) | 1.93332262 |
| 124 | Abnormal ciliary motility (HP:0012262) | 1.92359975 |
| 125 | Broad foot (HP:0001769) | 1.91978750 |
| 126 | Aplasia/Hypoplasia of the fibula (HP:0006492) | 1.91470208 |
| 127 | Preaxial hand polydactyly (HP:0001177) | 1.90502235 |
| 128 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 1.88791430 |
| 129 | Cutaneous syndactyly (HP:0012725) | 1.88561553 |
| 130 | Abnormal respiratory motile cilium physiology (HP:0012261) | 1.88148882 |
| 131 | Abnormal respiratory epithelium morphology (HP:0012253) | 1.87310695 |
| 132 | Abnormal respiratory motile cilium morphology (HP:0005938) | 1.87310695 |
| 133 | Partial duplication of the phalanx of hand (HP:0009999) | 1.87252169 |
| 134 | Labial hypoplasia (HP:0000066) | 1.87081094 |
| 135 | Humeroradial synostosis (HP:0003041) | 1.86587695 |
| 136 | Synostosis involving the elbow (HP:0003938) | 1.86587695 |
| 137 | Broad thumb (HP:0011304) | 1.86034293 |
| 138 | Hypoplastic female external genitalia (HP:0012815) | 1.85267075 |
| 139 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 1.84361445 |
| 140 | Ankyloglossia (HP:0010296) | 1.82307034 |
| 141 | Duplication of thumb phalanx (HP:0009942) | 1.81623096 |
| 142 | Postaxial foot polydactyly (HP:0001830) | 1.81288786 |
| 143 | Renal hypoplasia (HP:0000089) | 1.81095295 |
| 144 | Absent/shortened dynein arms (HP:0200106) | 1.81090183 |
| 145 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 1.81090183 |
| 146 | Progressive inability to walk (HP:0002505) | 1.79441532 |
| 147 | Neoplasm of the heart (HP:0100544) | 1.77030898 |
| 148 | Ectopic anus (HP:0004397) | 1.77004601 |
| 149 | Abnormality of oral frenula (HP:0000190) | 1.76721057 |
| 150 | Nephrogenic diabetes insipidus (HP:0009806) | 1.76272390 |
| 151 | Specific learning disability (HP:0001328) | 1.75865567 |
| 152 | Abnormality of the ischium (HP:0003174) | 1.75385264 |
| 153 | Spastic diplegia (HP:0001264) | 1.75330192 |
| 154 | Esophageal atresia (HP:0002032) | 1.75233083 |
| 155 | Abnormality of the septum pellucidum (HP:0007375) | 1.74225399 |
| 156 | Aplasia/Hypoplasia of the vertebrae (HP:0008515) | 1.72879134 |
| 157 | Vertebral hypoplasia (HP:0008417) | 1.72879134 |
| 158 | Abnormality of the renal medulla (HP:0100957) | 1.72830195 |
| 159 | Abnormality of the middle phalanges of the hand (HP:0009833) | 1.72479231 |
| 160 | Tracheomalacia (HP:0002779) | 1.68499256 |
| 161 | Bifid scrotum (HP:0000048) | 1.65524870 |
| 162 | Scrotal hypoplasia (HP:0000046) | 1.65106504 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CDK19 | 7.28390117 |
| 2 | EPHB2 | 4.67480035 |
| 3 | KSR1 | 4.31191376 |
| 4 | MAPK15 | 3.86856038 |
| 5 | WEE1 | 3.07346154 |
| 6 | TSSK6 | 2.94615633 |
| 7 | MAP3K10 | 2.86989085 |
| 8 | SIK3 | 2.63166389 |
| 9 | NTRK2 | 2.58171519 |
| 10 | MAPK13 | 2.57700025 |
| 11 | STK16 | 2.38728894 |
| 12 | MARK1 | 2.35452502 |
| 13 | EPHA3 | 2.26289170 |
| 14 | CSNK1G1 | 2.21906684 |
| 15 | TLK1 | 2.18759222 |
| 16 | DYRK3 | 2.13767447 |
| 17 | CSNK1G3 | 2.11907205 |
| 18 | CSNK1A1L | 1.98260820 |
| 19 | TNIK | 1.98047687 |
| 20 | VRK1 | 1.83377133 |
| 21 | CSNK1G2 | 1.76299134 |
| 22 | PHKG2 | 1.74575805 |
| 23 | PHKG1 | 1.74575805 |
| 24 | PAK3 | 1.74029376 |
| 25 | WNK3 | 1.71949472 |
| 26 | ERBB2 | 1.70498556 |
| 27 | VRK2 | 1.59364667 |
| 28 | CASK | 1.57286725 |
| 29 | PKN1 | 1.48187789 |
| 30 | MAP3K4 | 1.44215767 |
| 31 | TYRO3 | 1.42717654 |
| 32 | NTRK3 | 1.41316294 |
| 33 | TAF1 | 1.37309090 |
| 34 | PLK3 | 1.34070115 |
| 35 | DYRK2 | 1.32769304 |
| 36 | BCR | 1.32660609 |
| 37 | BUB1 | 1.26959084 |
| 38 | BMPR1B | 1.25596730 |
| 39 | MINK1 | 1.19872166 |
| 40 | ZAK | 1.07633813 |
| 41 | MOS | 1.06506923 |
| 42 | SIK1 | 1.03384929 |
| 43 | PASK | 1.03202090 |
| 44 | PINK1 | 0.99173992 |
| 45 | UHMK1 | 0.98322672 |
| 46 | KIT | 0.98048428 |
| 47 | CDK3 | 0.97282915 |
| 48 | SIK2 | 0.95387732 |
| 49 | ROCK2 | 0.95052822 |
| 50 | DYRK1B | 0.94124023 |
| 51 | PLK4 | 0.92794189 |
| 52 | TTK | 0.91771316 |
| 53 | CDK11A | 0.90660509 |
| 54 | PAK4 | 0.88913792 |
| 55 | NEK2 | 0.88662471 |
| 56 | LATS1 | 0.87700067 |
| 57 | NUAK1 | 0.85438297 |
| 58 | CDC7 | 0.81456607 |
| 59 | NTRK1 | 0.78750270 |
| 60 | ILK | 0.78725461 |
| 61 | LMTK2 | 0.78501451 |
| 62 | PTK6 | 0.77308631 |
| 63 | PLK1 | 0.76947064 |
| 64 | PAK6 | 0.73539511 |
| 65 | CDK14 | 0.71195033 |
| 66 | CDK18 | 0.69929082 |
| 67 | MAP3K9 | 0.69913150 |
| 68 | SRPK1 | 0.68964538 |
| 69 | EPHB1 | 0.68864607 |
| 70 | MARK3 | 0.66976648 |
| 71 | LRRK2 | 0.65770294 |
| 72 | ERBB3 | 0.64607915 |
| 73 | EPHA4 | 0.62521777 |
| 74 | STK38L | 0.61880957 |
| 75 | CAMK1G | 0.61589033 |
| 76 | CDK5 | 0.60887418 |
| 77 | CDK15 | 0.60827602 |
| 78 | STK11 | 0.59713576 |
| 79 | FES | 0.59542601 |
| 80 | YES1 | 0.58901620 |
| 81 | TYK2 | 0.58603768 |
| 82 | NLK | 0.58116991 |
| 83 | PRKD3 | 0.56852163 |
| 84 | NME1 | 0.54674237 |
| 85 | ROCK1 | 0.54614149 |
| 86 | BRSK2 | 0.54111779 |
| 87 | MKNK1 | 0.53366859 |
| 88 | TRIB3 | 0.52234650 |
| 89 | FGFR2 | 0.51806225 |
| 90 | FYN | 0.51213645 |
| 91 | DYRK1A | 0.50765027 |
| 92 | INSRR | 0.49683970 |
| 93 | STK24 | 0.49199915 |
| 94 | PBK | 0.48721784 |
| 95 | IRAK1 | 0.48539617 |
| 96 | LATS2 | 0.48009522 |
| 97 | RPS6KA4 | 0.47697652 |
| 98 | CHEK2 | 0.47690231 |
| 99 | TGFBR1 | 0.47208570 |
| 100 | MAP3K2 | 0.46812725 |
| 101 | GRK1 | 0.46811407 |
| 102 | BCKDK | 0.46105869 |
| 103 | ATR | 0.44634131 |
| 104 | CAMK1D | 0.44520697 |
| 105 | ADRBK2 | 0.44003466 |
| 106 | SRC | 0.43764175 |
| 107 | PLK2 | 0.42792869 |
| 108 | PAK2 | 0.41522474 |
| 109 | MAPKAPK5 | 0.41309729 |
| 110 | HIPK2 | 0.38944898 |
| 111 | PNCK | 0.38944485 |
| 112 | MAPK9 | 0.38264674 |
| 113 | GSK3A | 0.37585381 |
| 114 | MAP4K2 | 0.37561886 |
| 115 | PRKCE | 0.36578785 |
| 116 | PRKCZ | 0.36252300 |
| 117 | NEK1 | 0.35003883 |
| 118 | ATM | 0.34567568 |
| 119 | STK39 | 0.33854488 |
| 120 | MAP2K4 | 0.33772085 |
| 121 | TIE1 | 0.33178154 |
| 122 | WNK4 | 0.33177285 |
| 123 | FGFR1 | 0.33109051 |
| 124 | PRKCG | 0.32773707 |
| 125 | AURKB | 0.32686163 |
| 126 | ADRBK1 | 0.31010871 |
| 127 | CDK8 | 0.30601978 |
| 128 | STK3 | 0.30571383 |
| 129 | CSNK1A1 | 0.30546164 |
| 130 | AURKA | 0.30321523 |
| 131 | CSNK1D | 0.30290095 |
| 132 | TAOK1 | 0.28219830 |
| 133 | PRKCI | 0.26525864 |
| 134 | MAP2K2 | 0.26114572 |
| 135 | ERBB4 | 0.25212589 |
| 136 | PRKG1 | 0.24717519 |
| 137 | CAMK2A | 0.24562591 |
| 138 | MATK | 0.24221613 |
| 139 | ABL2 | 0.24067019 |
| 140 | CSNK1E | 0.23807302 |
| 141 | NME2 | 0.22292643 |
| 142 | AKT2 | 0.20379198 |
| 143 | CAMKK2 | 0.20046411 |
| 144 | DAPK1 | 0.19834034 |
| 145 | MAP2K7 | 0.19108334 |
| 146 | PRKACA | 0.19043936 |
| 147 | MKNK2 | 0.18873016 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 4.35934719 |
| 2 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 4.03440898 |
| 3 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 3.27848706 |
| 4 | Axon guidance_Homo sapiens_hsa04360 | 3.04839557 |
| 5 | Basal cell carcinoma_Homo sapiens_hsa05217 | 2.82424395 |
| 6 | Nitrogen metabolism_Homo sapiens_hsa00910 | 2.67330308 |
| 7 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 2.65411349 |
| 8 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 2.52084421 |
| 9 | Fatty acid elongation_Homo sapiens_hsa00062 | 2.48759472 |
| 10 | Steroid biosynthesis_Homo sapiens_hsa00100 | 2.43862986 |
| 11 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 2.41119988 |
| 12 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 2.33641058 |
| 13 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 2.12226456 |
| 14 | Melanogenesis_Homo sapiens_hsa04916 | 1.97551182 |
| 15 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.67583429 |
| 16 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.67078057 |
| 17 | Homologous recombination_Homo sapiens_hsa03440 | 1.63772286 |
| 18 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.63373011 |
| 19 | Glutamatergic synapse_Homo sapiens_hsa04724 | 1.63333830 |
| 20 | Nicotine addiction_Homo sapiens_hsa05033 | 1.61357563 |
| 21 | Long-term depression_Homo sapiens_hsa04730 | 1.58387424 |
| 22 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 1.50988292 |
| 23 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.49710770 |
| 24 | Taste transduction_Homo sapiens_hsa04742 | 1.42608145 |
| 25 | Wnt signaling pathway_Homo sapiens_hsa04310 | 1.41800574 |
| 26 | GABAergic synapse_Homo sapiens_hsa04727 | 1.38952622 |
| 27 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.36532487 |
| 28 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.31714767 |
| 29 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.29451463 |
| 30 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.29323860 |
| 31 | Basal transcription factors_Homo sapiens_hsa03022 | 1.28414102 |
| 32 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.26649981 |
| 33 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.25530523 |
| 34 | Alcoholism_Homo sapiens_hsa05034 | 1.23740663 |
| 35 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.20169079 |
| 36 | RNA degradation_Homo sapiens_hsa03018 | 1.17954952 |
| 37 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.17250977 |
| 38 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.16575356 |
| 39 | Parkinsons disease_Homo sapiens_hsa05012 | 1.12456334 |
| 40 | Spliceosome_Homo sapiens_hsa03040 | 1.11157955 |
| 41 | Insulin secretion_Homo sapiens_hsa04911 | 1.10832729 |
| 42 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.10455584 |
| 43 | Alzheimers disease_Homo sapiens_hsa05010 | 1.09905868 |
| 44 | Circadian entrainment_Homo sapiens_hsa04713 | 1.07262724 |
| 45 | Mineral absorption_Homo sapiens_hsa04978 | 1.05981360 |
| 46 | Cocaine addiction_Homo sapiens_hsa05030 | 1.05701671 |
| 47 | Gap junction_Homo sapiens_hsa04540 | 1.05356833 |
| 48 | Protein export_Homo sapiens_hsa03060 | 1.01634818 |
| 49 | Prion diseases_Homo sapiens_hsa05020 | 1.01051702 |
| 50 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.00705656 |
| 51 | Olfactory transduction_Homo sapiens_hsa04740 | 1.00424197 |
| 52 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.99988899 |
| 53 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.99029165 |
| 54 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.95076116 |
| 55 | Cell cycle_Homo sapiens_hsa04110 | 0.95047218 |
| 56 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.93913608 |
| 57 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.93630366 |
| 58 | DNA replication_Homo sapiens_hsa03030 | 0.93485715 |
| 59 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.92500517 |
| 60 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.92424740 |
| 61 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.92383854 |
| 62 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.89567251 |
| 63 | Long-term potentiation_Homo sapiens_hsa04720 | 0.89152044 |
| 64 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.87457477 |
| 65 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.86750894 |
| 66 | Morphine addiction_Homo sapiens_hsa05032 | 0.86213390 |
| 67 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.85274766 |
| 68 | RNA polymerase_Homo sapiens_hsa03020 | 0.84162823 |
| 69 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.82230718 |
| 70 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.81433597 |
| 71 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.80867886 |
| 72 | RNA transport_Homo sapiens_hsa03013 | 0.80559275 |
| 73 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.79516428 |
| 74 | Viral myocarditis_Homo sapiens_hsa05416 | 0.76085502 |
| 75 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.75904850 |
| 76 | Huntingtons disease_Homo sapiens_hsa05016 | 0.75155840 |
| 77 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.71908532 |
| 78 | Phototransduction_Homo sapiens_hsa04744 | 0.70910760 |
| 79 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.70144874 |
| 80 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.67182033 |
| 81 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.66816545 |
| 82 | Adherens junction_Homo sapiens_hsa04520 | 0.66200830 |
| 83 | Tight junction_Homo sapiens_hsa04530 | 0.65341639 |
| 84 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.64166246 |
| 85 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.63569800 |
| 86 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.63054646 |
| 87 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.60328646 |
| 88 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.59513405 |
| 89 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.58771290 |
| 90 | Renin secretion_Homo sapiens_hsa04924 | 0.58665014 |
| 91 | Peroxisome_Homo sapiens_hsa04146 | 0.58151528 |
| 92 | Sulfur relay system_Homo sapiens_hsa04122 | 0.56156390 |
| 93 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.55908309 |
| 94 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.55367766 |
| 95 | Pathways in cancer_Homo sapiens_hsa05200 | 0.54744911 |
| 96 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.54580385 |
| 97 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.53698638 |
| 98 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.53150359 |
| 99 | Colorectal cancer_Homo sapiens_hsa05210 | 0.50638289 |
| 100 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.49957391 |
| 101 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.49073583 |
| 102 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.49034933 |
| 103 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.48987430 |
| 104 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.48675537 |
| 105 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.48581083 |
| 106 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.47174273 |
| 107 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.45812053 |
| 108 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.45445265 |
| 109 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.44466360 |
| 110 | Purine metabolism_Homo sapiens_hsa00230 | 0.43859688 |
| 111 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.43524829 |
| 112 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.43413375 |
| 113 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.41980072 |
| 114 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.41403668 |
| 115 | Metabolic pathways_Homo sapiens_hsa01100 | 0.40327668 |
| 116 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.39876686 |
| 117 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.39350949 |
| 118 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.38265257 |
| 119 | Melanoma_Homo sapiens_hsa05218 | 0.38011372 |
| 120 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.36557895 |
| 121 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.35614938 |
| 122 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.32645174 |
| 123 | Retinol metabolism_Homo sapiens_hsa00830 | 0.32509697 |
| 124 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.31924628 |
| 125 | Mismatch repair_Homo sapiens_hsa03430 | 0.28878274 |
| 126 | Base excision repair_Homo sapiens_hsa03410 | 0.28493650 |
| 127 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.27402907 |
| 128 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.26820510 |
| 129 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.26361223 |
| 130 | Lysine degradation_Homo sapiens_hsa00310 | 0.25772848 |
| 131 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.25567834 |
| 132 | Proteasome_Homo sapiens_hsa03050 | 0.24710422 |
| 133 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.24685809 |
| 134 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.23127920 |
| 135 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.22152872 |
| 136 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.21564772 |
| 137 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.21237516 |

