FGFR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)5.10454970
2bone trabecula formation (GO:0060346)4.69430263
3regulation of posttranscriptional gene silencing (GO:0060147)4.57818530
4regulation of gene silencing by miRNA (GO:0060964)4.57818530
5regulation of gene silencing by RNA (GO:0060966)4.57818530
6planar cell polarity pathway involved in neural tube closure (GO:0090179)4.56102901
7collagen fibril organization (GO:0030199)4.52662512
8sequestering of extracellular ligand from receptor (GO:0035581)4.48413794
9regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.33365526
10neuron projection extension involved in neuron projection guidance (GO:1902284)4.17726759
11axon extension involved in axon guidance (GO:0048846)4.17726759
12chondrocyte proliferation (GO:0035988)4.16687758
13craniofacial suture morphogenesis (GO:0097094)3.82330510
14lateral sprouting from an epithelium (GO:0060601)3.80959389
15endodermal cell differentiation (GO:0035987)3.69675356
16positive regulation of SMAD protein import into nucleus (GO:0060391)3.64439698
17negative regulation of catenin import into nucleus (GO:0035414)3.58989133
18metanephric mesenchyme development (GO:0072075)3.57233675
19heterochromatin organization (GO:0070828)3.53754876
20dermatan sulfate biosynthetic process (GO:0030208)3.51330398
21negative regulation of chondrocyte differentiation (GO:0032331)3.46173080
22collagen metabolic process (GO:0032963)3.45703634
23hippo signaling (GO:0035329)3.43629103
24collagen catabolic process (GO:0030574)3.43490185
25kidney mesenchyme development (GO:0072074)3.39335952
26glomerular basement membrane development (GO:0032836)3.32509212
27G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.31351085
28basement membrane organization (GO:0071711)3.30707723
29cell proliferation involved in metanephros development (GO:0072203)3.30424262
30multicellular organismal macromolecule metabolic process (GO:0044259)3.28158228
31cell migration involved in sprouting angiogenesis (GO:0002042)3.26764147
32* regulation of cell fate specification (GO:0042659)3.23024789
33dermatan sulfate metabolic process (GO:0030205)3.20841337
34Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.20331858
35endothelial cell morphogenesis (GO:0001886)3.19656661
36pre-miRNA processing (GO:0031054)3.17093282
37regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.16832644
38* mesenchymal-epithelial cell signaling (GO:0060638)3.16172054
39multicellular organismal catabolic process (GO:0044243)3.13136646
40polarized epithelial cell differentiation (GO:0030859)3.12909639
41regulation of establishment of planar polarity (GO:0090175)3.12394806
42non-canonical Wnt signaling pathway (GO:0035567)3.11128657
43establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.11095963
44establishment of apical/basal cell polarity (GO:0035089)3.10344442
45embryonic cranial skeleton morphogenesis (GO:0048701)3.08314132
46multicellular organismal metabolic process (GO:0044236)3.07965318
47* outer ear morphogenesis (GO:0042473)3.05946689
48negative regulation of cartilage development (GO:0061037)3.01625891
49extracellular matrix disassembly (GO:0022617)2.98685626
50hemidesmosome assembly (GO:0031581)2.98620917
51* paraxial mesoderm development (GO:0048339)2.97406891
52presynaptic membrane assembly (GO:0097105)2.96786231
53convergent extension (GO:0060026)2.95584768
54mesenchymal to epithelial transition (GO:0060231)2.94310930
55positive regulation of catenin import into nucleus (GO:0035413)2.93985438
56proximal/distal pattern formation (GO:0009954)2.93420781
57cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.90526326
58cochlea morphogenesis (GO:0090103)2.88997697
59apoptotic cell clearance (GO:0043277)2.88939128
60anterior/posterior axis specification, embryo (GO:0008595)2.87756446
61insulin-like growth factor receptor signaling pathway (GO:0048009)2.83898677
62plasma membrane repair (GO:0001778)2.83449588
63negative regulation of cell fate specification (GO:0009996)2.83339960
64negative regulation of fatty acid transport (GO:2000192)2.82779057
65glial cell migration (GO:0008347)2.82251723
66bone morphogenesis (GO:0060349)2.81423618
67regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.80611982
68dorsal/ventral axis specification (GO:0009950)2.80053157
69regulation of SMAD protein import into nucleus (GO:0060390)2.79873344
70regulation of non-canonical Wnt signaling pathway (GO:2000050)2.78912783
71mesenchymal cell proliferation (GO:0010463)2.78106602
72chondrocyte development (GO:0002063)2.77828675
73cytoskeletal anchoring at plasma membrane (GO:0007016)2.77012495
74glomerular visceral epithelial cell development (GO:0072015)2.75340604
75establishment of tissue polarity (GO:0007164)2.75288656
76establishment of planar polarity (GO:0001736)2.75288656
77negative regulation of embryonic development (GO:0045992)2.74773845
78mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.74110453
79cell proliferation involved in kidney development (GO:0072111)2.73350720
80myelination in peripheral nervous system (GO:0022011)2.70342135
81peripheral nervous system axon ensheathment (GO:0032292)2.70342135
82cranial suture morphogenesis (GO:0060363)2.69856463
83negative regulation of androgen receptor signaling pathway (GO:0060766)2.69815547
84establishment or maintenance of monopolar cell polarity (GO:0061339)2.69417521
85establishment of monopolar cell polarity (GO:0061162)2.69417521
86negative regulation of smooth muscle cell migration (GO:0014912)2.68083949
87axis elongation (GO:0003401)2.67951142
88regulation of catenin import into nucleus (GO:0035412)2.67034451
89extracellular fibril organization (GO:0043206)2.66299827
90generation of neurons (GO:0048699)2.66115376
91negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.65982656
92regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.65963969
93regulation of cartilage development (GO:0061035)2.65919626
94anatomical structure regression (GO:0060033)2.65748096
95positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.65722023
96positive regulation of epithelial to mesenchymal transition (GO:0010718)2.65467123
97epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.64630067
98establishment or maintenance of bipolar cell polarity (GO:0061245)2.63361467
99establishment or maintenance of apical/basal cell polarity (GO:0035088)2.63361467
100regulation of chondrocyte differentiation (GO:0032330)2.61579104
101regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.61484850
102cell-substrate junction assembly (GO:0007044)2.60980505
103embryonic skeletal joint morphogenesis (GO:0060272)2.60697881
104neural tube development (GO:0021915)2.59456364
105skin morphogenesis (GO:0043589)2.58689139
106face morphogenesis (GO:0060325)2.58418287
107notochord development (GO:0030903)2.57806195
108renal filtration (GO:0097205)2.56775911
109cardiac epithelial to mesenchymal transition (GO:0060317)2.56752408
110protein complex localization (GO:0031503)2.56380079
111embryonic camera-type eye development (GO:0031076)2.56117846
112glomerular filtration (GO:0003094)2.55829900
113neural tube closure (GO:0001843)2.54345948
114* positive regulation of mesenchymal cell proliferation (GO:0002053)2.53885043
115negative regulation of osteoblast proliferation (GO:0033689)2.53663162
116cell migration involved in heart development (GO:0060973)2.53639528
117tube closure (GO:0060606)2.53580751
118camera-type eye morphogenesis (GO:0048593)2.53369902
119* branching involved in salivary gland morphogenesis (GO:0060445)2.53337787
120retina vasculature morphogenesis in camera-type eye (GO:0061299)2.52687388
121heart morphogenesis (GO:0003007)2.52560821
122L-serine metabolic process (GO:0006563)2.52521091
123* organ induction (GO:0001759)2.52520992
124positive regulation of smoothened signaling pathway (GO:0045880)2.50604070
125prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.50144976
126nodal signaling pathway (GO:0038092)2.49751386
127regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.49403956
128radial glial cell differentiation (GO:0060019)2.48854901
129substrate adhesion-dependent cell spreading (GO:0034446)2.48132073
130hindlimb morphogenesis (GO:0035137)2.47235047
131vasculature development (GO:0001944)2.46919454
132regulation of heart morphogenesis (GO:2000826)2.46073765
133regulation of axon extension involved in axon guidance (GO:0048841)2.45765703
134presynaptic membrane organization (GO:0097090)2.45113993
135extracellular negative regulation of signal transduction (GO:1900116)2.44959743
136extracellular regulation of signal transduction (GO:1900115)2.44959743
137negative regulation of fibroblast apoptotic process (GO:2000270)2.44848768
138establishment of integrated proviral latency (GO:0075713)2.44775331
139cellular response to vitamin D (GO:0071305)2.44485787
140pattern specification involved in kidney development (GO:0061004)2.43587068
141cell surface receptor signaling pathway involved in heart development (GO:0061311)2.43259130
142* regulation of mesenchymal cell proliferation (GO:0010464)2.42250785
143* regulation of gastrulation (GO:0010470)2.41811544
144* lung-associated mesenchyme development (GO:0060484)2.41600684
145mesenchyme morphogenesis (GO:0072132)2.41506673
146epithelial to mesenchymal transition (GO:0001837)2.40956382
147cellular response to vitamin (GO:0071295)2.39408689
148digestive tract morphogenesis (GO:0048546)2.38860201
149regulation of stem cell maintenance (GO:2000036)2.36698232
150negative regulation of cell fate commitment (GO:0010454)2.34582508
151glomerular epithelial cell development (GO:0072310)2.33855502
152adherens junction assembly (GO:0034333)2.33786671
153lens fiber cell development (GO:0070307)2.32150321
154apical protein localization (GO:0045176)2.31377396
155postsynaptic membrane organization (GO:0001941)2.27353121
156axon extension (GO:0048675)2.24333783
157dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.20198394

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.90481800
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.85983423
3RARG_19884340_ChIP-ChIP_MEFs_Mouse2.85120823
4POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.83079296
5EED_16625203_ChIP-ChIP_MESCs_Mouse2.49275235
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.44037269
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.44037269
8WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.41301267
9E2F7_22180533_ChIP-Seq_HELA_Human2.36302992
10* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.22683269
11EZH2_22144423_ChIP-Seq_EOC_Human2.21599088
12ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.20274448
13PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.14903824
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.13582466
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.13409979
16* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.05725045
17* POU5F1_16153702_ChIP-ChIP_HESCs_Human2.03512018
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.01988324
19TP53_20018659_ChIP-ChIP_R1E_Mouse1.97409900
20ZFP281_18757296_ChIP-ChIP_E14_Mouse1.95947687
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.95546466
22FOXM1_23109430_ChIP-Seq_U2OS_Human1.93707953
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.93345618
24EZH2_27304074_Chip-Seq_ESCs_Mouse1.92141796
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.86369929
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85884621
27ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.85087219
28* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.81492000
29PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.81002556
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.78815629
31SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.78655077
32CLOCK_20551151_ChIP-Seq_293T_Human1.76513576
33NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.74367944
34SALL1_21062744_ChIP-ChIP_HESCs_Human1.74047414
35* SOX2_16153702_ChIP-ChIP_HESCs_Human1.73040808
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.71800790
37TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.67120832
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.67036210
39NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.66741069
40SOX2_18555785_ChIP-Seq_MESCs_Mouse1.63720578
41* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.61626103
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61590630
43* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.59476067
44* NANOG_16153702_ChIP-ChIP_HESCs_Human1.58572252
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.55587900
46EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54325404
47TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.54257284
48* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.54020748
49MTF2_20144788_ChIP-Seq_MESCs_Mouse1.53927606
50WT1_19549856_ChIP-ChIP_CCG9911_Human1.52881283
51ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.52634864
52CJUN_26792858_Chip-Seq_BT549_Human1.52532368
53ESR1_21235772_ChIP-Seq_MCF-7_Human1.51633394
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.50983941
55DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.49866557
56DROSHA_22980978_ChIP-Seq_HELA_Human1.49423381
57* KDM2B_26808549_Chip-Seq_K562_Human1.49240808
58ISL1_27105846_Chip-Seq_CPCs_Mouse1.47960424
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.45492412
60KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.45480163
61KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.45480163
62KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.45480163
63* EP300_21415370_ChIP-Seq_HL-1_Mouse1.44104914
64SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.42600226
65RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.42039007
66* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.41910841
67ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41846330
68ERG_21242973_ChIP-ChIP_JURKAT_Human1.39359684
69RING1B_27294783_Chip-Seq_NPCs_Mouse1.39206472
70* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.39181977
71AR_21572438_ChIP-Seq_LNCaP_Human1.37135487
72* EZH2_27294783_Chip-Seq_ESCs_Mouse1.36325211
73SOX9_24532713_ChIP-Seq_HFSC_Mouse1.36114072
74* BRD4_25478319_ChIP-Seq_HGPS_Human1.35763636
75* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.35291063
76TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34955614
77CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.33435299
78RBPJ_22232070_ChIP-Seq_NCS_Mouse1.33375999
79HIF1A_21447827_ChIP-Seq_MCF-7_Human1.32426010
80POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.32006685
81TP53_18474530_ChIP-ChIP_U2OS_Human1.31160148
82* RING1B_27294783_Chip-Seq_ESCs_Mouse1.30957356
83CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.30887042
84* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30338692
85HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.29830004
86TP53_16413492_ChIP-PET_HCT116_Human1.28497257
87CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28443856
88TP63_19390658_ChIP-ChIP_HaCaT_Human1.27943714
89* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.24181797
90GATA1_26923725_Chip-Seq_HPCs_Mouse1.23829180
91P300_27058665_Chip-Seq_ZR-75-30cells_Human1.23059567
92TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.22618357
93IKZF1_21737484_ChIP-ChIP_HCT116_Human1.20137840
94* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.19996891
95SUZ12_27294783_Chip-Seq_ESCs_Mouse1.18769838
96AHR_22903824_ChIP-Seq_MCF-7_Human1.18648292
97NANOG_21062744_ChIP-ChIP_HESCs_Human1.18194232
98* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17431966
99ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15109157
100* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.14745784
101SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.13847436
102* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13454675
103AR_21909140_ChIP-Seq_LNCAP_Human1.13365667
104MYC_18555785_ChIP-Seq_MESCs_Mouse1.12522097
105TP53_23651856_ChIP-Seq_MEFs_Mouse1.11412136
106KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11004453
107CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10404296
108TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08271141
109NFIB_24661679_ChIP-Seq_LUNG_Mouse1.08095136
110* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.07902242
111FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.07375938
112* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.07195990
113* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.06738341
114TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06044837
115ARNT_22903824_ChIP-Seq_MCF-7_Human1.05198820
116* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.05028274
117TBX3_20139965_ChIP-Seq_ESCs_Mouse1.04856034
118* ELK3_25401928_ChIP-Seq_HUVEC_Human1.04303543
119DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03624915
120TBX3_20139965_ChIP-Seq_MESCs_Mouse1.03603367
121GBX2_23144817_ChIP-Seq_PC3_Human1.02088395
122NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01168567
123NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01168567
124THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00250842
125SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.99761862
126* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.99699680
127* KDM2B_26808549_Chip-Seq_JURKAT_Human0.97814661
128* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97560856
129* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.97061730
130RACK7_27058665_Chip-Seq_MCF-7_Human0.96054054
131SOX9_26525672_Chip-Seq_HEART_Mouse0.95896740
132RXR_22108803_ChIP-Seq_LS180_Human0.95568743
133PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95317664
134* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.94759734
135CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93636441
136NANOG_18555785_ChIP-Seq_MESCs_Mouse0.90503609
137* NANOG_16518401_ChIP-PET_MESCs_Mouse0.86671853
138TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85974880
139SOX3_22085726_ChIP-Seq_NPCs_Mouse0.85263447

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.78245336
2MP0005503_abnormal_tendon_morphology4.07652035
3MP0005275_abnormal_skin_tensile3.56897813
4MP0003705_abnormal_hypodermis_morpholog3.25732343
5MP0010030_abnormal_orbit_morphology3.17384927
6MP0004272_abnormal_basement_membrane3.15229745
7MP0002254_reproductive_system_inflammat3.11990086
8MP0005623_abnormal_meninges_morphology2.85049265
9MP0003279_aneurysm2.59293641
10MP0009250_abnormal_appendicular_skeleto2.21865784
11MP0005508_abnormal_skeleton_morphology2.12472995
12MP0001958_emphysema2.11693816
13MP0003385_abnormal_body_wall2.11056728
14MP0003136_yellow_coat_color2.08412066
15MP0006292_abnormal_olfactory_placode1.97104787
16MP0002108_abnormal_muscle_morphology1.92935806
17MP0009053_abnormal_anal_canal1.84531376
18MP0002249_abnormal_larynx_morphology1.82575435
19MP0000534_abnormal_ureter_morphology1.79519158
20MP0005257_abnormal_intraocular_pressure1.79490977
21* MP0003942_abnormal_urinary_system1.75096223
22* MP0000428_abnormal_craniofacial_morphol1.74073774
23MP0000733_abnormal_muscle_development1.70574635
24MP0004858_abnormal_nervous_system1.65389738
25MP0003566_abnormal_cell_adhesion1.62974808
26* MP0000049_abnormal_middle_ear1.61875936
27MP0009672_abnormal_birth_weight1.60364988
28MP0000566_synostosis1.59127115
29MP0003122_maternal_imprinting1.58860667
30MP0003283_abnormal_digestive_organ1.56795538
31MP0002932_abnormal_joint_morphology1.56162538
32* MP0001299_abnormal_eye_distance/1.56132414
33MP0000537_abnormal_urethra_morphology1.54778959
34MP0002282_abnormal_trachea_morphology1.53782042
35MP0003941_abnormal_skin_development1.51880118
36MP0002896_abnormal_bone_mineralization1.49563251
37* MP0003755_abnormal_palate_morphology1.49213948
38MP0002060_abnormal_skin_morphology1.47813559
39MP0000751_myopathy1.47744406
40MP0009384_cardiac_valve_regurgitation1.45058728
41MP0003115_abnormal_respiratory_system1.44868916
42* MP0002116_abnormal_craniofacial_bone1.40266400
43MP0000750_abnormal_muscle_regeneration1.38279503
44* MP0000432_abnormal_head_morphology1.35347497
45* MP0003935_abnormal_craniofacial_develop1.34149788
46* MP0000163_abnormal_cartilage_morphology1.32939249
47MP0005076_abnormal_cell_differentiation1.32787189
48MP0003890_abnormal_embryonic-extraembry1.32391222
49MP0003091_abnormal_cell_migration1.32163661
50MP0004134_abnormal_chest_morphology1.26100380
51MP0001286_abnormal_eye_development1.25705978
52MP0002233_abnormal_nose_morphology1.24489723
53MP0006054_spinal_hemorrhage1.23870361
54* MP0003937_abnormal_limbs/digits/tail_de1.23391037
55* MP0002115_abnormal_skeleton_extremities1.22594451
56* MP0000762_abnormal_tongue_morphology1.21290001
57* MP0002085_abnormal_embryonic_tissue1.21048007
58MP0005670_abnormal_white_adipose1.19269257
59MP0005248_abnormal_Harderian_gland1.19022593
60MP0004233_abnormal_muscle_weight1.16419087
61MP0010368_abnormal_lymphatic_system1.15782496
62MP0005023_abnormal_wound_healing1.15707881
63MP0000767_abnormal_smooth_muscle1.14509469
64* MP0003861_abnormal_nervous_system1.13934465
65MP0003045_fibrosis1.13611592
66* MP0000778_abnormal_nervous_system1.12893924
67* MP0002109_abnormal_limb_morphology1.11591479
68MP0002089_abnormal_postnatal_growth/wei1.10614873
69* MP0002084_abnormal_developmental_patter1.10320675
70MP0004859_abnormal_synaptic_plasticity1.09693585
71MP0002938_white_spotting1.08529580
72MP0002295_abnormal_pulmonary_circulatio1.08375611
73MP0009703_decreased_birth_body1.06548169
74* MP0002114_abnormal_axial_skeleton1.02440835
75MP0003123_paternal_imprinting1.01222084
76MP0002168_other_aberrant_phenotype0.98020787
77* MP0002113_abnormal_skeleton_development0.97401249
78MP0002653_abnormal_ependyma_morphology0.97101757
79MP0000462_abnormal_digestive_system0.95445550
80MP0005390_skeleton_phenotype0.94377078
81MP0004133_heterotaxia0.94034835
82MP0002234_abnormal_pharynx_morphology0.93575858
83MP0000003_abnormal_adipose_tissue0.92967813
84MP0009379_abnormal_foot_pigmentation0.92888463
85MP0004185_abnormal_adipocyte_glucose0.92754423
86MP0009780_abnormal_chondrocyte_physiolo0.91571621
87MP0005367_renal/urinary_system_phenotyp0.91409769
88MP0000516_abnormal_urinary_system0.91409769
89* MP0002111_abnormal_tail_morphology0.90627825
90* MP0002925_abnormal_cardiovascular_devel0.86963004
91MP0000759_abnormal_skeletal_muscle0.86497570
92MP0005375_adipose_tissue_phenotype0.86462584
93MP0001293_anophthalmia0.85878511
94MP0001542_abnormal_bone_strength0.85747466
95* MP0008932_abnormal_embryonic_tissue0.85431799
96MP0002697_abnormal_eye_size0.84888479
97MP0004197_abnormal_fetal_growth/weight/0.84568132
98MP0004145_abnormal_muscle_electrophysio0.84469604
99MP0001915_intracranial_hemorrhage0.83802916
100MP0010352_gastrointestinal_tract_polyps0.83463216
101MP0001243_abnormal_dermal_layer0.82309590
102MP0001177_atelectasis0.81732369
103MP0005197_abnormal_uvea_morphology0.80662161
104* MP0002081_perinatal_lethality0.79025315
105* MP0003938_abnormal_ear_development0.78967348
106MP0002092_abnormal_eye_morphology0.78892872
107MP0005595_abnormal_vascular_smooth0.78032349
108* MP0001614_abnormal_blood_vessel0.77766029
109MP0000579_abnormal_nail_morphology0.77381350
110* MP0005380_embryogenesis_phenotype0.77364500
111* MP0001672_abnormal_embryogenesis/_devel0.77364500
112MP0005666_abnormal_adipose_tissue0.77057582
113MP0001270_distended_abdomen0.76919304
114MP0005187_abnormal_penis_morphology0.76644478
115MP0001879_abnormal_lymphatic_vessel0.76132526
116* MP0001849_ear_inflammation0.75162580
117MP0001175_abnormal_lung_morphology0.74428465
118MP0005171_absent_coat_pigmentation0.74162217
119MP0005499_abnormal_olfactory_system0.73384054
120MP0005394_taste/olfaction_phenotype0.73384054
121MP0001730_embryonic_growth_arrest0.73299312
122* MP0002177_abnormal_outer_ear0.72641213
123MP0001340_abnormal_eyelid_morphology0.72476111
124MP0008789_abnormal_olfactory_epithelium0.71826496
125MP0003121_genomic_imprinting0.71793588
126MP0003119_abnormal_digestive_system0.71359602
127MP0004957_abnormal_blastocyst_morpholog0.71163826
128MP0002128_abnormal_blood_circulation0.71084671
129* MP0003984_embryonic_growth_retardation0.69351900
130MP0000013_abnormal_adipose_tissue0.68805633
131MP0003111_abnormal_nucleus_morphology0.67523032
132* MP0002088_abnormal_embryonic_growth/wei0.67013948

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.61519430
2Premature rupture of membranes (HP:0001788)5.29974217
3* Shallow orbits (HP:0000586)4.77088522
4Ankle contracture (HP:0006466)4.27153405
5Atrophic scars (HP:0001075)3.90924583
6* Broad metatarsal (HP:0001783)3.51536795
7Short 4th metacarpal (HP:0010044)3.37192214
8Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.37192214
9Cerebral aneurysm (HP:0004944)3.26988450
10Bladder diverticulum (HP:0000015)3.26557824
11Partial duplication of thumb phalanx (HP:0009944)3.24455235
12Cervical subluxation (HP:0003308)3.18592696
13Partial duplication of the phalanx of hand (HP:0009999)3.18478065
14Aortic dissection (HP:0002647)3.13436201
15Type 1 muscle fiber predominance (HP:0003803)3.09712040
16Neonatal short-limb short stature (HP:0008921)3.06784161
17Soft skin (HP:0000977)3.06499612
18Follicular hyperkeratosis (HP:0007502)3.04069846
19Fragile skin (HP:0001030)2.96233791
20Wrist flexion contracture (HP:0001239)2.95393620
21Abnormality of dentin (HP:0010299)2.75100489
22Spinal rigidity (HP:0003306)2.73097605
23Peritonitis (HP:0002586)2.70769236
24Abnormality of the 4th metacarpal (HP:0010012)2.69288309
25Increased connective tissue (HP:0009025)2.55581990
26Renal duplication (HP:0000075)2.54833177
27Genu recurvatum (HP:0002816)2.49603909
28Bell-shaped thorax (HP:0001591)2.49137767
29Mesomelia (HP:0003027)2.48167707
30Aplasia of the phalanges of the hand (HP:0009802)2.46949230
31Aplasia involving bones of the extremities (HP:0009825)2.46949230
32Aplasia involving bones of the upper limbs (HP:0009823)2.46949230
33Abnormality of the parietal bone (HP:0002696)2.39973244
34Dilatation of the ascending aorta (HP:0005111)2.38127386
35Wormian bones (HP:0002645)2.37777274
36Mitral valve prolapse (HP:0001634)2.36111404
37Blue sclerae (HP:0000592)2.34594908
38Bowel diverticulosis (HP:0005222)2.33811145
39Slender build (HP:0001533)2.33473846
40Hyperextensible skin (HP:0000974)2.31109117
41Overriding aorta (HP:0002623)2.26157036
42Mildly elevated creatine phosphokinase (HP:0008180)2.25385267
43Duplication of thumb phalanx (HP:0009942)2.24070741
44Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.23622847
45Aortic aneurysm (HP:0004942)2.23091314
46Hepatoblastoma (HP:0002884)2.21764705
47Increased variability in muscle fiber diameter (HP:0003557)2.21496320
48Elfin facies (HP:0004428)2.21219754
49Cutaneous finger syndactyly (HP:0010554)2.17098982
50Cutaneous syndactyly (HP:0012725)2.16935279
51Wide anterior fontanel (HP:0000260)2.14102085
52Joint laxity (HP:0001388)2.12989242
53* Choanal stenosis (HP:0000452)2.12808596
54Hallux valgus (HP:0001822)2.09688298
55Vitreoretinal degeneration (HP:0000655)2.09257015
56Morphological abnormality of the middle ear (HP:0008609)2.07371058
57* Turricephaly (HP:0000262)2.06713551
58Biconcave vertebral bodies (HP:0004586)2.04514848
59* Deviation of the hallux (HP:0010051)2.04479622
60Calcaneovalgus deformity (HP:0001848)2.01985810
61Flat cornea (HP:0007720)2.00830037
62Vascular tortuosity (HP:0004948)1.99683310
63Abnormality of the distal phalanx of the thumb (HP:0009617)1.98640477
64Spastic diplegia (HP:0001264)1.98153956
65Ectopia lentis (HP:0001083)1.98072385
66Hypoplastic ischia (HP:0003175)1.98004101
67Syringomyelia (HP:0003396)1.97615998
68Spinal cord lesions (HP:0100561)1.97615998
69* Broad long bones (HP:0005622)1.97082597
70Overgrowth (HP:0001548)1.96500709
71Spondylolisthesis (HP:0003302)1.96363658
72Buphthalmos (HP:0000557)1.96272784
73Elbow flexion contracture (HP:0002987)1.95141514
74* Broad finger (HP:0001500)1.93421834
75Abnormal number of incisors (HP:0011064)1.89667583
76* Broad phalanges of the hand (HP:0009768)1.88920630
77* Septo-optic dysplasia (HP:0100842)1.88413534
78* Arnold-Chiari malformation (HP:0002308)1.87928522
79Abnormality of skeletal muscle fiber size (HP:0012084)1.87820923
80Arterial tortuosity (HP:0005116)1.86694581
81Abnormality of the nasal septum (HP:0000419)1.85811747
82Infantile muscular hypotonia (HP:0008947)1.85645584
83Protruding ear (HP:0000411)1.85431625
84Renovascular hypertension (HP:0100817)1.84811564
85Deformed tarsal bones (HP:0008119)1.84640656
86Hip contracture (HP:0003273)1.83378366
87Mild short stature (HP:0003502)1.82804615
88Narrow nasal bridge (HP:0000446)1.82071573
89* Preaxial foot polydactyly (HP:0001841)1.81495824
90Short nail (HP:0001799)1.81338832
91Hyperacusis (HP:0010780)1.80619407
92Narrow palate (HP:0000189)1.80069304
93Down-sloping shoulders (HP:0200021)1.79968236
94Broad ribs (HP:0000885)1.79154030
95Midline defect of the nose (HP:0004122)1.78746595
96Anophthalmia (HP:0000528)1.78399109
97Vertebral arch anomaly (HP:0008438)1.77735413
98Abnormality of abdominal situs (HP:0011620)1.77732687
99Abdominal situs inversus (HP:0003363)1.77732687
100Hypoventilation (HP:0002791)1.76946475
101Ulnar bowing (HP:0003031)1.76838057
102Bilateral microphthalmos (HP:0007633)1.76576162
103Thin ribs (HP:0000883)1.75437787
104Limited hip movement (HP:0008800)1.74671137
105Abnormality of the ischium (HP:0003174)1.74500287
106Asymmetry of the thorax (HP:0001555)1.72966209
107Abnormality of the calcaneus (HP:0008364)1.72174215
108Milia (HP:0001056)1.72033247
109Aneurysm (HP:0002617)1.70808831
110Increased nuchal translucency (HP:0010880)1.70369937
111Skull defect (HP:0001362)1.70286091
112Abnormality of the diencephalon (HP:0010662)1.70187104
113Exostoses (HP:0100777)1.69851093
114* Coronal craniosynostosis (HP:0004440)1.69412786
115* Broad toe (HP:0001837)1.69165589
116Vertebral compression fractures (HP:0002953)1.68879411
117Disproportionate tall stature (HP:0001519)1.68292985
118* Broad phalanx (HP:0006009)1.68143589
119Myelomeningocele (HP:0002475)1.67589428
120Colon cancer (HP:0003003)1.67526407
121Scapular winging (HP:0003691)1.67244565
122Knee flexion contracture (HP:0006380)1.66641334
123High anterior hairline (HP:0009890)1.66517148
124* Trigonocephaly (HP:0000243)1.66139369
125Tracheomalacia (HP:0002779)1.65594037
126Abnormality of the acetabulum (HP:0003170)1.65156444
127Camptodactyly of toe (HP:0001836)1.65136958
128Abnormality of the labia minora (HP:0012880)1.65019244
129Abnormality of the antihelix (HP:0009738)1.64820010
130Vertebral clefting (HP:0008428)1.64803626
131Mitral regurgitation (HP:0001653)1.64565408
132Radial bowing (HP:0002986)1.63697751
133Limb-girdle muscle weakness (HP:0003325)1.63487750
134Natal tooth (HP:0000695)1.63087144
135* Broad thumb (HP:0011304)1.62974428
136Breech presentation (HP:0001623)1.61860878
137Insomnia (HP:0100785)1.61534246
138Microglossia (HP:0000171)1.60710113
139Bowed forearm bones (HP:0003956)1.60658924
140Bowing of the arm (HP:0006488)1.60658924
141Absent frontal sinuses (HP:0002688)1.60644699
142Aortic valve stenosis (HP:0001650)1.60550605
143Selective tooth agenesis (HP:0001592)1.59866111
144Delayed cranial suture closure (HP:0000270)1.58642879

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.65611475
2LATS13.87757333
3TRIB33.65037062
4LATS23.59016650
5PDGFRA3.43183473
6EPHB23.07550472
7SIK13.06102750
8RIPK12.83653426
9TTN2.55375010
10CAMK1D2.14226415
11CAMK1G2.11372221
12TNIK2.06990893
13CDC71.98967961
14EPHA31.92997570
15FER1.87316608
16TTK1.81568425
17CDK121.80658570
18PKN21.78726554
19ERN11.74803089
20MYLK1.61190515
21PTK21.59367918
22FGFR21.58309602
23DYRK21.50870064
24TIE11.47856910
25CASK1.44739773
26TAF11.42584946
27PRKD31.35352335
28PTK61.32568266
29EPHA21.31281607
30NEK21.30800566
31MET1.30724395
32PAK21.28800746
33MAP3K91.26300222
34STK381.24573141
35VRK21.24133889
36MTOR1.23932023
37PAK41.23441152
38PDGFRB1.22580164
39EPHA41.20458974
40DMPK1.20059380
41SMG11.19456166
42ERBB41.19039872
43NTRK11.17993157
44LMTK21.17928477
45* FGFR11.17315321
46ICK1.09135341
47PLK31.06760585
48ROCK11.05677769
49STK38L1.05296176
50EPHB11.04363915
51BUB11.01966496
52PAK61.00214637
53STK30.98723961
54WNK10.95704020
55ROCK20.93806773
56MARK10.91172934
57NLK0.90608916
58NTRK30.88664566
59PAK30.86610457
60EEF2K0.84245920
61CDK190.83407684
62MST1R0.80629746
63PLK20.79731474
64TSSK60.78771046
65RET0.76535783
66MARK20.76128345
67PRKCH0.75967456
68CDC42BPA0.73377401
69LIMK10.73072642
70MKNK20.71988285
71ALK0.71949685
72PRKD20.71742817
73PHKG20.70914043
74PHKG10.70914043
75ERBB20.69815503
76TYRO30.69748119
77DYRK30.68803680
78WEE10.68677441
79CHEK20.68508137
80MAP3K100.67030321
81MOS0.66348047
82FLT30.66243033
83PRPF4B0.66229672
84UHMK10.65493019
85RPS6KA20.64281943
86TAOK20.63171127
87MKNK10.62827179
88CDK60.62319740
89ILK0.62013728
90NTRK20.59943725
91PLK10.59784481
92PTK2B0.59297310
93CDK70.58709782
94PASK0.57899014
95* BMX0.57008162
96MAP2K10.55473553
97AKT20.54607899
98BRD40.53198926
99MAP3K70.52839581
100TGFBR10.52355421
101LRRK20.51664911
102PRKDC0.50296949
103SGK2230.49966851
104SGK4940.49966851
105SRC0.49524592
106TGFBR20.49135204
107CHEK10.47188143
108FGFR30.43859564
109PRKD10.43494115
110CAMKK10.43268070
111RPS6KL10.42601358
112RPS6KC10.42601358
113CAMK40.41960309
114CSNK1E0.41798194
115PRKCG0.41653795
116CAMK10.41619759
117STK40.41282345
118DAPK30.41205803
119CDK10.40557008
120ATM0.40294179
121KSR10.39552840
122TRPM70.39299893
123PRKG20.38983868
124PLK40.38670978
125MAPK80.38665515
126ERBB30.37776300
127PIK3CA0.37565881
128DYRK1A0.37460649
129WNK30.37380429
130BCR0.37331381
131* INSR0.37176575
132CDK150.36919458
133* MAPK10.36020550
134CSNK1G10.35747907
135AURKB0.35723018
136FGFR40.34312568
137CDK180.33621547
138CDK140.33505439
139MINK10.32896603
140SCYL20.32510175
141GSK3A0.32157040
142MAPK100.31604354
143ADRBK10.31373701
144NEK90.30365625
145CDK11A0.29712502
146PNCK0.29305651
147AKT10.28764464
148MAPK90.28475789
149SGK30.28072809
150MATK0.27850211
151TAOK10.27368472

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.49469544
2Basal cell carcinoma_Homo sapiens_hsa052172.99326960
3Hedgehog signaling pathway_Homo sapiens_hsa043402.56787544
4Focal adhesion_Homo sapiens_hsa045102.41174305
5Protein digestion and absorption_Homo sapiens_hsa049742.20632709
6Hippo signaling pathway_Homo sapiens_hsa043902.19900665
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.18745402
8* Proteoglycans in cancer_Homo sapiens_hsa052052.07856910
9Dilated cardiomyopathy_Homo sapiens_hsa054141.82528902
10* Adherens junction_Homo sapiens_hsa045201.82040474
11Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.78367845
12TGF-beta signaling pathway_Homo sapiens_hsa043501.76494714
13Amoebiasis_Homo sapiens_hsa051461.73632983
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.71719850
15Bladder cancer_Homo sapiens_hsa052191.64554630
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.64411087
17Wnt signaling pathway_Homo sapiens_hsa043101.62731989
18AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.59440805
19* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.57945545
20MicroRNAs in cancer_Homo sapiens_hsa052061.55120711
21Small cell lung cancer_Homo sapiens_hsa052221.49656556
22Axon guidance_Homo sapiens_hsa043601.49151591
23Melanogenesis_Homo sapiens_hsa049161.48339185
24Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.43192005
25Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.42581519
26* Melanoma_Homo sapiens_hsa052181.34097292
27Vitamin B6 metabolism_Homo sapiens_hsa007501.32475142
28Glioma_Homo sapiens_hsa052141.30694673
29* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.30131532
30* Pathways in cancer_Homo sapiens_hsa052001.28300560
31Notch signaling pathway_Homo sapiens_hsa043301.25177918
32mRNA surveillance pathway_Homo sapiens_hsa030151.22304180
33Chronic myeloid leukemia_Homo sapiens_hsa052201.22264134
34Selenocompound metabolism_Homo sapiens_hsa004501.21715700
35* Regulation of actin cytoskeleton_Homo sapiens_hsa048101.20087697
36* Rap1 signaling pathway_Homo sapiens_hsa040151.17796436
37Cell cycle_Homo sapiens_hsa041101.17025247
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.16522509
39DNA replication_Homo sapiens_hsa030301.15179180
40Endometrial cancer_Homo sapiens_hsa052131.10294823
41Tight junction_Homo sapiens_hsa045301.09561474
42Thyroid hormone signaling pathway_Homo sapiens_hsa049191.06358370
43Gap junction_Homo sapiens_hsa045401.03885930
44GnRH signaling pathway_Homo sapiens_hsa049120.99702497
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99340008
46Steroid biosynthesis_Homo sapiens_hsa001000.99099704
47Estrogen signaling pathway_Homo sapiens_hsa049150.98502521
48Mismatch repair_Homo sapiens_hsa034300.94771434
49Biosynthesis of amino acids_Homo sapiens_hsa012300.94363430
50Colorectal cancer_Homo sapiens_hsa052100.94325992
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.92692901
52Spliceosome_Homo sapiens_hsa030400.92655885
53Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.92369075
54* Prostate cancer_Homo sapiens_hsa052150.92049475
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90293344
56Viral myocarditis_Homo sapiens_hsa054160.89536185
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.88151332
58mTOR signaling pathway_Homo sapiens_hsa041500.87552285
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87312157
60Pancreatic cancer_Homo sapiens_hsa052120.84572325
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.84239238
62Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83478622
63RNA transport_Homo sapiens_hsa030130.83278659
64HTLV-I infection_Homo sapiens_hsa051660.82624688
65Renal cell carcinoma_Homo sapiens_hsa052110.82575584
66ErbB signaling pathway_Homo sapiens_hsa040120.82198076
67* Central carbon metabolism in cancer_Homo sapiens_hsa052300.82172804
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.81699474
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.81468409
70Malaria_Homo sapiens_hsa051440.80527159
71Circadian entrainment_Homo sapiens_hsa047130.78784925
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.78250820
73Dorso-ventral axis formation_Homo sapiens_hsa043200.78138577
74Lysine degradation_Homo sapiens_hsa003100.78042369
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.77110669
76Glycosaminoglycan degradation_Homo sapiens_hsa005310.76316735
77cAMP signaling pathway_Homo sapiens_hsa040240.76022441
78Salivary secretion_Homo sapiens_hsa049700.75760245
79Gastric acid secretion_Homo sapiens_hsa049710.75489460
80HIF-1 signaling pathway_Homo sapiens_hsa040660.73888339
81Long-term depression_Homo sapiens_hsa047300.73039062
82Oxytocin signaling pathway_Homo sapiens_hsa049210.73010300
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72415365
84Aldosterone synthesis and secretion_Homo sapiens_hsa049250.71998099
85* Ras signaling pathway_Homo sapiens_hsa040140.71864311
86Thyroid cancer_Homo sapiens_hsa052160.69956777
87* MAPK signaling pathway_Homo sapiens_hsa040100.67914513
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67601184
89Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67449870
90Fatty acid biosynthesis_Homo sapiens_hsa000610.67317338
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67062748
92Platelet activation_Homo sapiens_hsa046110.66036831
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.65190874
94Insulin secretion_Homo sapiens_hsa049110.65007374
95AMPK signaling pathway_Homo sapiens_hsa041520.64908678
96Non-small cell lung cancer_Homo sapiens_hsa052230.64508508
97Insulin signaling pathway_Homo sapiens_hsa049100.63750448
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63123700
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61987151
100Prion diseases_Homo sapiens_hsa050200.61977023
101Long-term potentiation_Homo sapiens_hsa047200.60880631
102Base excision repair_Homo sapiens_hsa034100.60727556
103Ribosome_Homo sapiens_hsa030100.60451788
104Renin secretion_Homo sapiens_hsa049240.60012168
105FoxO signaling pathway_Homo sapiens_hsa040680.59797049
106Vascular smooth muscle contraction_Homo sapiens_hsa042700.59423772
107Cardiac muscle contraction_Homo sapiens_hsa042600.58902429
108Thyroid hormone synthesis_Homo sapiens_hsa049180.58710529
109Calcium signaling pathway_Homo sapiens_hsa040200.58558145
110Non-homologous end-joining_Homo sapiens_hsa034500.58156784
111Glutamatergic synapse_Homo sapiens_hsa047240.57347994
112Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56613977
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56474219
114Cholinergic synapse_Homo sapiens_hsa047250.55137719
115One carbon pool by folate_Homo sapiens_hsa006700.54611555
116VEGF signaling pathway_Homo sapiens_hsa043700.53950988
117Ovarian steroidogenesis_Homo sapiens_hsa049130.53791002
118Glucagon signaling pathway_Homo sapiens_hsa049220.53454431
119Toxoplasmosis_Homo sapiens_hsa051450.53268231
120Oocyte meiosis_Homo sapiens_hsa041140.51941568
121Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51758095
122Insulin resistance_Homo sapiens_hsa049310.51741363
123Cocaine addiction_Homo sapiens_hsa050300.51729887
124p53 signaling pathway_Homo sapiens_hsa041150.50188832
125Choline metabolism in cancer_Homo sapiens_hsa052310.50129497
126Pyruvate metabolism_Homo sapiens_hsa006200.49138480
127Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48432814
128Folate biosynthesis_Homo sapiens_hsa007900.47122698
129Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45651364
130Nucleotide excision repair_Homo sapiens_hsa034200.45628691
1312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44000948
132Nicotine addiction_Homo sapiens_hsa050330.43544620
133Galactose metabolism_Homo sapiens_hsa000520.41191828
134RNA polymerase_Homo sapiens_hsa030200.38948273
135Carbon metabolism_Homo sapiens_hsa012000.36002653

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