FGFR1OP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a largely hydrophilic centrosomal protein that is required for anchoring microtubules to subcellular structures. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. Alterations in this gene may also be associated with Crohn's disease, Graves' disease, and vitiligo. Alternatively spliced transcript variants that encode different proteins have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1attachment of spindle microtubules to kinetochore (GO:0008608)4.89193578
2protein localization to kinetochore (GO:0034501)4.58693499
3kinetochore organization (GO:0051383)4.55590554
4nuclear pore organization (GO:0006999)4.54668108
5meiotic chromosome segregation (GO:0045132)4.50124473
6mitotic metaphase plate congression (GO:0007080)4.41340465
7CENP-A containing nucleosome assembly (GO:0034080)4.40898269
8chromatin remodeling at centromere (GO:0031055)4.40384524
9metaphase plate congression (GO:0051310)4.29978372
10nucleobase biosynthetic process (GO:0046112)4.26479044
11purine nucleobase biosynthetic process (GO:0009113)4.25973652
12nuclear pore complex assembly (GO:0051292)4.25842231
13DNA strand elongation (GO:0022616)4.21345405
14kinetochore assembly (GO:0051382)4.20386838
15protein localization to chromosome, centromeric region (GO:0071459)4.15201312
16DNA unwinding involved in DNA replication (GO:0006268)4.11822795
17DNA strand elongation involved in DNA replication (GO:0006271)4.09261836
18telomere maintenance via semi-conservative replication (GO:0032201)4.01856582
19DNA replication-independent nucleosome organization (GO:0034724)4.00164319
20DNA replication-independent nucleosome assembly (GO:0006336)4.00164319
21behavioral response to nicotine (GO:0035095)3.99788268
22indole-containing compound catabolic process (GO:0042436)3.99755735
23indolalkylamine catabolic process (GO:0046218)3.99755735
24tryptophan catabolic process (GO:0006569)3.99755735
25epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.98501496
26cilium or flagellum-dependent cell motility (GO:0001539)3.94775395
27histone exchange (GO:0043486)3.91540745
28ribosomal small subunit assembly (GO:0000028)3.90897639
29mitotic chromosome condensation (GO:0007076)3.90459492
30DNA replication initiation (GO:0006270)3.89813248
31mitotic sister chromatid cohesion (GO:0007064)3.85295295
32indolalkylamine metabolic process (GO:0006586)3.84641345
33kynurenine metabolic process (GO:0070189)3.83281762
34mitotic nuclear envelope disassembly (GO:0007077)3.83241251
35DNA replication checkpoint (GO:0000076)3.83025447
36DNA replication-dependent nucleosome organization (GO:0034723)3.80853319
37DNA replication-dependent nucleosome assembly (GO:0006335)3.80853319
38telomere maintenance via recombination (GO:0000722)3.79566763
39mitotic recombination (GO:0006312)3.75604435
40somatic diversification of immune receptors via somatic mutation (GO:0002566)3.69450842
41somatic hypermutation of immunoglobulin genes (GO:0016446)3.69450842
42telomere maintenance via telomere lengthening (GO:0010833)3.64673026
43response to pheromone (GO:0019236)3.63684453
44regulation of centriole replication (GO:0046599)3.62055979
45protein polyglutamylation (GO:0018095)3.60565898
46maturation of SSU-rRNA (GO:0030490)3.59611073
47establishment of chromosome localization (GO:0051303)3.59233206
48sulfation (GO:0051923)3.55925160
49viral mRNA export from host cell nucleus (GO:0046784)3.54361144
50membrane disassembly (GO:0030397)3.53249834
51nuclear envelope disassembly (GO:0051081)3.53249834
52centriole replication (GO:0007099)3.52479735
53epithelial cilium movement (GO:0003351)3.52434657
54regulation of spindle organization (GO:0090224)3.50189393
55detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.48765761
56telomere maintenance via telomerase (GO:0007004)3.45102288
57tryptophan metabolic process (GO:0006568)3.43558209
58axoneme assembly (GO:0035082)3.40494962
59IMP biosynthetic process (GO:0006188)3.40384111
60mitotic sister chromatid segregation (GO:0000070)3.38244833
61formation of translation preinitiation complex (GO:0001731)3.34499368
62regulation of nuclear cell cycle DNA replication (GO:0033262)3.31165034
63nucleotide-excision repair, DNA gap filling (GO:0006297)3.30697589
64water-soluble vitamin biosynthetic process (GO:0042364)3.30206173
65RNA-dependent DNA replication (GO:0006278)3.29026185
66synapsis (GO:0007129)3.28513443
67cilium movement (GO:0003341)3.27954870
68sister chromatid segregation (GO:0000819)3.27357904
69maturation of 5.8S rRNA (GO:0000460)3.27153158
70replication fork processing (GO:0031297)3.27002823
71regulation of centrosome cycle (GO:0046605)3.23727664
72gamma-aminobutyric acid transport (GO:0015812)3.23526444
73L-fucose catabolic process (GO:0042355)3.22755288
74fucose catabolic process (GO:0019317)3.22755288
75L-fucose metabolic process (GO:0042354)3.22755288
76piRNA metabolic process (GO:0034587)3.22418269
77DNA deamination (GO:0045006)3.22241726
78DNA synthesis involved in DNA repair (GO:0000731)3.21837690
79pseudouridine synthesis (GO:0001522)3.21781116
80telomere organization (GO:0032200)3.21691591
81negative regulation of DNA-dependent DNA replication (GO:2000104)3.21554958
82telomere maintenance (GO:0000723)3.21128561
83interkinetic nuclear migration (GO:0022027)3.20874966
84detection of light stimulus involved in sensory perception (GO:0050962)3.20809387
85detection of light stimulus involved in visual perception (GO:0050908)3.20809387
86regulation of double-strand break repair via homologous recombination (GO:0010569)3.20141956
87pore complex assembly (GO:0046931)3.17612238
88regulation of gene silencing by miRNA (GO:0060964)3.17118760
89regulation of gene silencing by RNA (GO:0060966)3.17118760
90regulation of posttranscriptional gene silencing (GO:0060147)3.17118760
91ribosome biogenesis (GO:0042254)3.16251598
92chromatin assembly or disassembly (GO:0006333)3.16151200
93ribosomal large subunit biogenesis (GO:0042273)3.13607262
94recombinational repair (GO:0000725)3.12286247
95double-strand break repair via homologous recombination (GO:0000724)3.12023376
96DNA methylation involved in gamete generation (GO:0043046)3.11791040
97protein localization to chromosome (GO:0034502)3.11141453
98mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.11039848
99mitochondrial respiratory chain complex I assembly (GO:0032981)3.11039848
100NADH dehydrogenase complex assembly (GO:0010257)3.11039848
101rRNA catabolic process (GO:0016075)3.10509250
102preassembly of GPI anchor in ER membrane (GO:0016254)3.09842813
103spliceosomal snRNP assembly (GO:0000387)3.08016217
104regulation of histone H3-K9 methylation (GO:0051570)3.07832158
105regulation of mesoderm development (GO:2000380)3.07544050
106DNA duplex unwinding (GO:0032508)3.06929356
107spindle checkpoint (GO:0031577)3.06284592
108regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.05834933
109sperm motility (GO:0030317)3.03582571
110DNA packaging (GO:0006323)3.03579261
111DNA geometric change (GO:0032392)3.03498131
112regulation of hippo signaling (GO:0035330)3.00526128
113ribosome assembly (GO:0042255)3.00258520
114intra-S DNA damage checkpoint (GO:0031573)3.00143736
115regulation of mitotic spindle checkpoint (GO:1903504)3.00099066
116regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.00099066
117spindle assembly checkpoint (GO:0071173)2.99563813
118mismatch repair (GO:0006298)2.99500836
119chromosome segregation (GO:0007059)2.99128479
120kidney morphogenesis (GO:0060993)2.98621805
121regulation of DNA endoreduplication (GO:0032875)2.98491692
122DNA conformation change (GO:0071103)2.97245869
123rRNA processing (GO:0006364)2.96850273
124chromosome condensation (GO:0030261)2.96516607
125ribonucleoprotein complex biogenesis (GO:0022613)2.95986455
126regulation of chromosome segregation (GO:0051983)2.95452772
127sister chromatid cohesion (GO:0007062)2.94764347
128mRNA export from nucleus (GO:0006406)2.94652178
129maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.94624494
130IMP metabolic process (GO:0046040)2.94550148
131somite development (GO:0061053)2.94086774
132negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.93907341
133postreplication repair (GO:0006301)2.93856640
134resolution of meiotic recombination intermediates (GO:0000712)2.93843439
135negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.93297556
136negative regulation of sister chromatid segregation (GO:0033046)2.93297556
137negative regulation of mitotic sister chromatid separation (GO:2000816)2.93297556
138negative regulation of mitotic sister chromatid segregation (GO:0033048)2.93297556
139monoubiquitinated protein deubiquitination (GO:0035520)2.92868379
140termination of RNA polymerase II transcription (GO:0006369)2.92476299
141negative regulation of chromosome segregation (GO:0051985)2.91592906
142RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.91578252
143RNA export from nucleus (GO:0006405)2.90170146
144histone H2A acetylation (GO:0043968)2.89580459
145indole-containing compound metabolic process (GO:0042430)2.88744886
146regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.88599900
147rRNA metabolic process (GO:0016072)2.88304391
148male meiosis I (GO:0007141)2.87334381
149photoreceptor cell maintenance (GO:0045494)2.86258416
150regulation of meiosis I (GO:0060631)2.83769184
151reciprocal DNA recombination (GO:0035825)2.82854511
152reciprocal meiotic recombination (GO:0007131)2.82854511
153protein K11-linked deubiquitination (GO:0035871)2.80278274
154regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.79537490
155negative regulation of translation, ncRNA-mediated (GO:0040033)2.76614952
156regulation of translation, ncRNA-mediated (GO:0045974)2.76614952
157negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.76614952
158reflex (GO:0060004)2.76008175
159multicellular organism reproduction (GO:0032504)2.75385847
160protein complex biogenesis (GO:0070271)2.75104141
161cellular ketone body metabolic process (GO:0046950)2.74935994
162primary amino compound metabolic process (GO:1901160)2.74144427
163regulation of cilium movement (GO:0003352)2.73095693
164positive regulation of oligodendrocyte differentiation (GO:0048714)2.72242300
165neural tube formation (GO:0001841)2.72235930
166axonemal dynein complex assembly (GO:0070286)2.69510689
167nonmotile primary cilium assembly (GO:0035058)2.68457095
168negative regulation of mast cell activation (GO:0033004)2.68275088
169cilium organization (GO:0044782)2.66246665
170spinal cord motor neuron differentiation (GO:0021522)2.65576708
171oxidative demethylation (GO:0070989)2.65179769
172cilium morphogenesis (GO:0060271)2.62998082
173mitochondrial respiratory chain complex assembly (GO:0033108)2.60218705
174serotonin metabolic process (GO:0042428)2.57286892
175cilium assembly (GO:0042384)2.55740573
176negative regulation of transcription regulatory region DNA binding (GO:2000678)2.54660312
177centrosome organization (GO:0051297)2.54608290
178replicative senescence (GO:0090399)2.53731579
179centriole assembly (GO:0098534)2.53119825
180protein K48-linked deubiquitination (GO:0071108)2.52707437
181negative regulation of astrocyte differentiation (GO:0048712)2.52555559
182GPI anchor metabolic process (GO:0006505)2.51616676
183cellular response to ATP (GO:0071318)2.48660399
184microtubule organizing center organization (GO:0031023)2.47814929
185aromatic amino acid family catabolic process (GO:0009074)2.47689268
186benzene-containing compound metabolic process (GO:0042537)2.47056862
187ncRNA catabolic process (GO:0034661)2.46515690
188ketone body metabolic process (GO:1902224)2.45559633
189regulation of non-canonical Wnt signaling pathway (GO:2000050)2.45046578
190cell proliferation in forebrain (GO:0021846)2.45040386
191thyroid hormone metabolic process (GO:0042403)2.43830452
192limb development (GO:0060173)2.42316026

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.87934246
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.41966175
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.16019084
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.90542330
5* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.42602164
6VDR_22108803_ChIP-Seq_LS180_Human3.34448915
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.28722935
8ZNF274_21170338_ChIP-Seq_K562_Hela3.19421532
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.09340276
10EZH2_22144423_ChIP-Seq_EOC_Human3.01113677
11GBX2_23144817_ChIP-Seq_PC3_Human2.93085588
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.92243946
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.79588642
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.77788805
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.65890840
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.65146800
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.64367900
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.60581203
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.58856209
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.57725777
21IGF1R_20145208_ChIP-Seq_DFB_Human2.53266508
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.50746681
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.45134166
24ETS1_20019798_ChIP-Seq_JURKAT_Human2.43004953
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.38850488
26VDR_23849224_ChIP-Seq_CD4+_Human2.38415944
27POU3F2_20337985_ChIP-ChIP_501MEL_Human2.37540987
28EWS_26573619_Chip-Seq_HEK293_Human2.37113390
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.35913850
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.34983213
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.34546002
32* FUS_26573619_Chip-Seq_HEK293_Human2.29352872
33ELF1_17652178_ChIP-ChIP_JURKAT_Human2.25800217
34E2F1_21310950_ChIP-Seq_MCF-7_Human2.22616508
35NELFA_20434984_ChIP-Seq_ESCs_Mouse2.22388138
36CTBP2_25329375_ChIP-Seq_LNCAP_Human2.21047565
37FOXP3_21729870_ChIP-Seq_TREG_Human2.17659979
38* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.16311884
39TAF15_26573619_Chip-Seq_HEK293_Human2.16114355
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.15748886
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15289283
42AR_21909140_ChIP-Seq_LNCAP_Human2.14133646
43P300_19829295_ChIP-Seq_ESCs_Human2.08888400
44CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02831219
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.00355114
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.98962172
47XRN2_22483619_ChIP-Seq_HELA_Human1.95351532
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.94969508
49ER_23166858_ChIP-Seq_MCF-7_Human1.93769900
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.93242552
51MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.92181796
52SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.91242892
53IRF1_19129219_ChIP-ChIP_H3396_Human1.90534009
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.90250047
55ELK1_19687146_ChIP-ChIP_HELA_Human1.88161955
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.81141752
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.79232226
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.79062084
59* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.76994918
60NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.76260714
61GABP_19822575_ChIP-Seq_HepG2_Human1.73676610
62E2F1_18555785_ChIP-Seq_MESCs_Mouse1.73038268
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.72623159
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.71914050
65STAT3_23295773_ChIP-Seq_U87_Human1.71197334
66POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70906513
67DCP1A_22483619_ChIP-Seq_HELA_Human1.69595509
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.67750547
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67628207
70THAP11_20581084_ChIP-Seq_MESCs_Mouse1.65088474
71GATA1_22025678_ChIP-Seq_K562_Human1.60168410
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.59815858
73CBP_20019798_ChIP-Seq_JUKART_Human1.59815858
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.58962381
75TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55477971
76TTF2_22483619_ChIP-Seq_HELA_Human1.54909870
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.54320588
78* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.54094181
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53838951
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.53659752
81RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53210751
82* TCF4_23295773_ChIP-Seq_U87_Human1.52033853
83BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49982435
84* SMAD4_21799915_ChIP-Seq_A2780_Human1.49515478
85CIITA_25753668_ChIP-Seq_RAJI_Human1.49483785
86SRF_21415370_ChIP-Seq_HL-1_Mouse1.47288905
87KDM5A_27292631_Chip-Seq_BREAST_Human1.46848942
88ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46516226
89ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46281853
90PADI4_21655091_ChIP-ChIP_MCF-7_Human1.45879450
91ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43946126
92ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.43599501
93MYC_22102868_ChIP-Seq_BL_Human1.41761188
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40782329
95BCAT_22108803_ChIP-Seq_LS180_Human1.40487658
96SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.40272986
97SMAD3_21741376_ChIP-Seq_EPCs_Human1.40076846
98NR3C1_21868756_ChIP-Seq_MCF10A_Human1.38959962
99BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.38321375
100PIAS1_25552417_ChIP-Seq_VCAP_Human1.36914188
101TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36884530
102FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36184664
103AR_25329375_ChIP-Seq_VCAP_Human1.34802420
104NANOG_19829295_ChIP-Seq_ESCs_Human1.34148903
105SOX2_19829295_ChIP-Seq_ESCs_Human1.34148903
106* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34135135
107* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34135135
108SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.33595398
109HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33043335
110PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32965650
111IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.31114903
112KLF5_20875108_ChIP-Seq_MESCs_Mouse1.30175747
113SCL_19346495_ChIP-Seq_HPC-7_Human1.28710207
114ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28378784
115TP53_22573176_ChIP-Seq_HFKS_Human1.28177082
116FOXA1_25329375_ChIP-Seq_VCAP_Human1.26811790
117FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26811790
118YY1_21170310_ChIP-Seq_MESCs_Mouse1.26008634
119PRDM14_20953172_ChIP-Seq_ESCs_Human1.25375274
120TCF4_22108803_ChIP-Seq_LS180_Human1.25151316
121NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24984536
122EZH2_27294783_Chip-Seq_NPCs_Mouse1.24391496
123SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24139293
124PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21117491
125RNF2_27304074_Chip-Seq_NSC_Mouse1.21033343
126RUNX2_22187159_ChIP-Seq_PCA_Human1.20705723
127SMAD4_21741376_ChIP-Seq_EPCs_Human1.19619784
128NFE2_27457419_Chip-Seq_LIVER_Mouse1.19303595
129AR_21572438_ChIP-Seq_LNCaP_Human1.19257338
130GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18896079
131AUTS2_25519132_ChIP-Seq_293T-REX_Human1.18138407
132CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17797626
133EGR1_19374776_ChIP-ChIP_THP-1_Human1.17030748
134E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16893723
135TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16285534
136CBX2_27304074_Chip-Seq_ESCs_Mouse1.16253046
137CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15742793
138* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15491418
139FLI1_21867929_ChIP-Seq_TH2_Mouse1.14780013
140SPI1_23547873_ChIP-Seq_NB4_Human1.13453686
141SALL1_21062744_ChIP-ChIP_HESCs_Human1.11494731
142TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10086971
143MYC_18940864_ChIP-ChIP_HL60_Human1.09896361
144CDX2_22108803_ChIP-Seq_LS180_Human1.08965760
145EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08586554
146NANOG_18555785_Chip-Seq_ESCs_Mouse1.08147139
147* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07375252
148SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06632923
149NCOR_22424771_ChIP-Seq_293T_Human1.06547340
150REST_21632747_ChIP-Seq_MESCs_Mouse1.05778918
151CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04910953
152GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04666343
153OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03824419
154AR_20517297_ChIP-Seq_VCAP_Human1.02514962
155TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02293399
156EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02086791
157POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01471978
158POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00396463
159GATA3_21878914_ChIP-Seq_MCF-7_Human0.99924957
160ETV1_20927104_ChIP-Seq_GIST48_Human0.99466557
161TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99123302
162CRX_20693478_ChIP-Seq_RETINA_Mouse0.97867618
163HOXB7_26014856_ChIP-Seq_BT474_Human0.97629593
164JUN_21703547_ChIP-Seq_K562_Human0.97040623
165P53_22387025_ChIP-Seq_ESCs_Mouse0.96087395
166IRF8_22096565_ChIP-ChIP_GC-B_Human0.96074478
167PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95271011
168ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93287264
169CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.91259412
170SOX2_18555785_ChIP-Seq_MESCs_Mouse0.88236166
171TFEB_21752829_ChIP-Seq_HELA_Human0.87547553
172KLF4_18555785_ChIP-Seq_MESCs_Mouse0.86824448
173MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.83997587
174BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.81300922
175CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.81295253
176STAT3_1855785_ChIP-Seq_MESCs_Mouse0.80931638
177DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.79059016
178MYB_21317192_ChIP-Seq_ERMYB_Mouse0.78375714
179MYB_26560356_Chip-Seq_TH1_Human0.77718486
180CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.76717784
181CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.76627613
182CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.76074190
183CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.75760141
184TP63_19390658_ChIP-ChIP_HaCaT_Human0.75224941
185MYB_26560356_Chip-Seq_TH2_Human0.72773992
186* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70283966
187GATA2_22383799_ChIP-Seq_G1ME_Mouse0.68490289
188ELK1_22589737_ChIP-Seq_MCF10A_Human0.66672133
189VDR_21846776_ChIP-Seq_THP-1_Human0.65630593
190* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.63929971

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.19239295
2MP0008057_abnormal_DNA_replication4.57143053
3MP0003693_abnormal_embryo_hatching4.46196130
4MP0003111_abnormal_nucleus_morphology4.29397988
5MP0003077_abnormal_cell_cycle3.99247536
6MP0008058_abnormal_DNA_repair3.89609772
7MP0008877_abnormal_DNA_methylation3.75374061
8MP0004957_abnormal_blastocyst_morpholog3.68629262
9MP0002396_abnormal_hematopoietic_system3.28625461
10MP0003646_muscle_fatigue3.24214076
11MP0008007_abnormal_cellular_replicative2.78952636
12MP0006054_spinal_hemorrhage2.72309903
13MP0003195_calcinosis2.56140911
14MP0003123_paternal_imprinting2.46017085
15MP0005646_abnormal_pituitary_gland2.41430866
16MP0003786_premature_aging2.23374187
17MP0004808_abnormal_hematopoietic_stem2.22909687
18MP0008932_abnormal_embryonic_tissue2.21945235
19MP0005551_abnormal_eye_electrophysiolog2.20437745
20MP0002837_dystrophic_cardiac_calcinosis2.13649671
21MP0006072_abnormal_retinal_apoptosis2.13114183
22MP0002102_abnormal_ear_morphology2.01979424
23MP0001485_abnormal_pinna_reflex1.95867743
24MP0001730_embryonic_growth_arrest1.88839149
25MP0000350_abnormal_cell_proliferation1.87624046
26MP0010307_abnormal_tumor_latency1.83032328
27MP0002210_abnormal_sex_determination1.82729215
28MP0000490_abnormal_crypts_of1.79602558
29MP0001968_abnormal_touch/_nociception1.79379351
30MP0000631_abnormal_neuroendocrine_gland1.74323740
31MP0001929_abnormal_gametogenesis1.74185334
32MP0003136_yellow_coat_color1.73946002
33MP0004142_abnormal_muscle_tone1.73539475
34MP0009046_muscle_twitch1.73288419
35MP0005253_abnormal_eye_physiology1.68968781
36MP0002653_abnormal_ependyma_morphology1.68307998
37MP0004147_increased_porphyrin_level1.67893334
38MP0008872_abnormal_physiological_respon1.64567034
39MP0002398_abnormal_bone_marrow1.62980183
40MP0002876_abnormal_thyroid_physiology1.59796782
41MP0001835_abnormal_antigen_presentation1.59302867
42MP0002138_abnormal_hepatobiliary_system1.58911059
43MP0005389_reproductive_system_phenotype1.56213346
44MP0001145_abnormal_male_reproductive1.55751438
45MP0002938_white_spotting1.50529049
46MP0000313_abnormal_cell_death1.48932844
47MP0002736_abnormal_nociception_after1.46872163
48MP0000383_abnormal_hair_follicle1.45932271
49MP0000703_abnormal_thymus_morphology1.44170182
50MP0000689_abnormal_spleen_morphology1.43672027
51MP0001672_abnormal_embryogenesis/_devel1.43344576
52MP0005380_embryogenesis_phenotype1.43344576
53MP0009745_abnormal_behavioral_response1.42497002
54MP0001697_abnormal_embryo_size1.39374582
55MP0009697_abnormal_copulation1.39203144
56MP0003984_embryonic_growth_retardation1.38261286
57MP0000427_abnormal_hair_cycle1.37846526
58MP0000653_abnormal_sex_gland1.36817886
59MP0004043_abnormal_pH_regulation1.36797431
60MP0004145_abnormal_muscle_electrophysio1.36668549
61MP0002722_abnormal_immune_system1.36210756
62MP0003121_genomic_imprinting1.35727560
63MP0003763_abnormal_thymus_physiology1.35483712
64MP0008789_abnormal_olfactory_epithelium1.35047455
65MP0002019_abnormal_tumor_incidence1.34121107
66MP0002088_abnormal_embryonic_growth/wei1.34072786
67MP0002272_abnormal_nervous_system1.34037242
68MP0003119_abnormal_digestive_system1.33731756
69MP0008875_abnormal_xenobiotic_pharmacok1.33235723
70MP0002080_prenatal_lethality1.32092102
71MP0001486_abnormal_startle_reflex1.29847707
72MP0005377_hearing/vestibular/ear_phenot1.29565534
73MP0003878_abnormal_ear_physiology1.29565534
74MP0004885_abnormal_endolymph1.27453076
75MP0001800_abnormal_humoral_immune1.25804235
76MP0000049_abnormal_middle_ear1.22549192
77MP0005174_abnormal_tail_pigmentation1.21963111
78MP0003806_abnormal_nucleotide_metabolis1.21833557
79MP0003698_abnormal_male_reproductive1.21709791
80MP0005410_abnormal_fertilization1.20651910
81MP0010352_gastrointestinal_tract_polyps1.20419559
82MP0001501_abnormal_sleep_pattern1.19870123
83MP0000716_abnormal_immune_system1.17696403
84MP0002429_abnormal_blood_cell1.17670068
85MP0006276_abnormal_autonomic_nervous1.17106980
86MP0008995_early_reproductive_senescence1.16474430
87MP0004197_abnormal_fetal_growth/weight/1.15783644
88MP0001293_anophthalmia1.15253790
89MP0009333_abnormal_splenocyte_physiolog1.14904397
90MP0000372_irregular_coat_pigmentation1.14831938
91MP0006292_abnormal_olfactory_placode1.13846442
92MP0005671_abnormal_response_to1.13480280
93MP0003890_abnormal_embryonic-extraembry1.13293337
94MP0003252_abnormal_bile_duct1.12605105
95MP0003567_abnormal_fetal_cardiomyocyte1.11927498
96MP0001986_abnormal_taste_sensitivity1.11329026
97MP0002234_abnormal_pharynx_morphology1.10968972
98MP0005397_hematopoietic_system_phenotyp1.10009222
99MP0001545_abnormal_hematopoietic_system1.10009222
100MP0002928_abnormal_bile_duct1.06444667
101MP0002095_abnormal_skin_pigmentation1.06084487
102MP0005645_abnormal_hypothalamus_physiol1.05488271
103MP0004133_heterotaxia1.05473406
104MP0000685_abnormal_immune_system1.05438444
105MP0009672_abnormal_birth_weight1.05330805
106MP0002638_abnormal_pupillary_reflex1.05260941
107MP0002086_abnormal_extraembryonic_tissu1.05003800
108MP0005075_abnormal_melanosome_morpholog1.04674066
109MP0002084_abnormal_developmental_patter1.04416837
110MP0002735_abnormal_chemical_nociception1.04397665
111MP0003943_abnormal_hepatobiliary_system1.03640390
112MP0001984_abnormal_olfaction1.01823671
113MP0003656_abnormal_erythrocyte_physiolo1.01416412
114MP0002452_abnormal_antigen_presenting1.01365105
115MP0002085_abnormal_embryonic_tissue1.01107764
116MP0002420_abnormal_adaptive_immunity1.01037479
117MP0005085_abnormal_gallbladder_physiolo1.00607424
118MP0009053_abnormal_anal_canal1.00183384
119MP0001853_heart_inflammation0.99438841
120MP0000015_abnormal_ear_pigmentation0.98914295
121MP0001819_abnormal_immune_cell0.98681487
122MP0001919_abnormal_reproductive_system0.97063323
123MP0005195_abnormal_posterior_eye0.95746174
124MP0001529_abnormal_vocalization0.94534415
125MP0002557_abnormal_social/conspecific_i0.93689601
126MP0002723_abnormal_immune_serum0.92729390
127MP0004233_abnormal_muscle_weight0.92139811
128MP0003718_maternal_effect0.91949370
129MP0005084_abnormal_gallbladder_morpholo0.90776624
130MP0004742_abnormal_vestibular_system0.89761000
131MP0001963_abnormal_hearing_physiology0.88713018
132MP0001764_abnormal_homeostasis0.88114567
133MP0001119_abnormal_female_reproductive0.87577973
134MP0000569_abnormal_digit_pigmentation0.87323536
135MP0005670_abnormal_white_adipose0.87092817
136MP0002572_abnormal_emotion/affect_behav0.86123867
137MP0005360_urolithiasis0.84020238
138MP0005499_abnormal_olfactory_system0.83787584
139MP0005394_taste/olfaction_phenotype0.83787584
140MP0003011_delayed_dark_adaptation0.81571688
141MP0002064_seizures0.80184103
142MP0000026_abnormal_inner_ear0.79945460
143MP0005391_vision/eye_phenotype0.78555140
144MP0006035_abnormal_mitochondrial_morpho0.77767826
145MP0006036_abnormal_mitochondrial_physio0.77174297
146MP0003787_abnormal_imprinting0.77052760
147MP0002161_abnormal_fertility/fecundity0.76236629
148MP0008775_abnormal_heart_ventricle0.76082489
149MP0009703_decreased_birth_body0.75495265
150MP0005332_abnormal_amino_acid0.75001629
151MP0002752_abnormal_somatic_nervous0.74111770
152MP0002067_abnormal_sensory_capabilities0.73864032
153MP0001188_hyperpigmentation0.73738058
154MP0001915_intracranial_hemorrhage0.73528479
155MP0001324_abnormal_eye_pigmentation0.72441335
156MP0005025_abnormal_response_to0.72347620
157MP0005464_abnormal_platelet_physiology0.72286539
158MP0002160_abnormal_reproductive_system0.71408401
159MP0003938_abnormal_ear_development0.71286232
160MP0005395_other_phenotype0.71106367
161MP0002733_abnormal_thermal_nociception0.70621301
162MP0005000_abnormal_immune_tolerance0.66406457
163MP0005384_cellular_phenotype0.66258260
164MP0003950_abnormal_plasma_membrane0.64308321
165MP0002006_tumorigenesis0.62894108
166MP0003315_abnormal_perineum_morphology0.62491990
167MP0002166_altered_tumor_susceptibility0.60428415
168MP0005621_abnormal_cell_physiology0.58841868
169MP0003937_abnormal_limbs/digits/tail_de0.56704660
170MP0009785_altered_susceptibility_to0.56224116
171MP0000358_abnormal_cell_content/0.55341037
172MP0002075_abnormal_coat/hair_pigmentati0.54644014
173MP0003186_abnormal_redox_activity0.53973956

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.48767510
2Agnosia (HP:0010524)4.40538885
3Pancreatic cysts (HP:0001737)4.36275927
4Aplastic anemia (HP:0001915)3.89988141
5Pancreatic fibrosis (HP:0100732)3.88758061
6Metaphyseal dysplasia (HP:0100255)3.74049136
7True hermaphroditism (HP:0010459)3.71797299
8Abnormal number of erythroid precursors (HP:0012131)3.71262948
9Abnormality of cells of the erythroid lineage (HP:0012130)3.51202180
10Abnormality of midbrain morphology (HP:0002418)3.45354054
11Molar tooth sign on MRI (HP:0002419)3.45354054
12Genetic anticipation (HP:0003743)3.44955068
13Chromsome breakage (HP:0040012)3.31812183
14Nephronophthisis (HP:0000090)3.31605642
15Congenital stationary night blindness (HP:0007642)3.25932587
16Abnormality of the anterior horn cell (HP:0006802)3.22690508
17Degeneration of anterior horn cells (HP:0002398)3.22690508
18Oral leukoplakia (HP:0002745)3.16576345
19Supernumerary spleens (HP:0009799)3.16448193
20Rough bone trabeculation (HP:0100670)3.15001407
21Chromosomal breakage induced by crosslinking agents (HP:0003221)3.07809438
22Colon cancer (HP:0003003)3.07534355
23Reticulocytopenia (HP:0001896)3.02373004
24Abnormal lung lobation (HP:0002101)2.97426836
25Medulloblastoma (HP:0002885)2.97116390
26Chronic hepatic failure (HP:0100626)2.94165091
27Selective tooth agenesis (HP:0001592)2.93646876
28Abnormality of the renal medulla (HP:0100957)2.90947665
29Abnormal spermatogenesis (HP:0008669)2.90109266
3011 pairs of ribs (HP:0000878)2.88890786
31Abnormality of the renal cortex (HP:0011035)2.85403534
32Cystic liver disease (HP:0006706)2.82621115
33Pendular nystagmus (HP:0012043)2.82410300
34Progressive cerebellar ataxia (HP:0002073)2.81727502
35Gaze-evoked nystagmus (HP:0000640)2.80903775
36Abnormality of chromosome stability (HP:0003220)2.75065362
37Acute myeloid leukemia (HP:0004808)2.74291550
38Myelodysplasia (HP:0002863)2.71930344
39Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.71721873
40Abnormality of alanine metabolism (HP:0010916)2.71721873
41Hyperalaninemia (HP:0003348)2.71721873
42Attenuation of retinal blood vessels (HP:0007843)2.71459124
43Absent frontal sinuses (HP:0002688)2.70446251
44Abnormality of the labia minora (HP:0012880)2.65153088
45Cellular immunodeficiency (HP:0005374)2.63500340
46Abnormality of the preputium (HP:0100587)2.61746632
47Abolished electroretinogram (ERG) (HP:0000550)2.60359185
48Ependymoma (HP:0002888)2.57630629
49IgM deficiency (HP:0002850)2.57614938
50Abnormal ciliary motility (HP:0012262)2.57018899
51Premature graying of hair (HP:0002216)2.56523337
52Nephroblastoma (Wilms tumor) (HP:0002667)2.55500432
53Bone marrow hypocellularity (HP:0005528)2.52849716
54Abnormality of lateral ventricle (HP:0030047)2.52070819
55Spinal cord lesions (HP:0100561)2.49797374
56Syringomyelia (HP:0003396)2.49797374
57Atrophy/Degeneration involving motor neurons (HP:0007373)2.46793519
58Medial flaring of the eyebrow (HP:0010747)2.45444539
59Sloping forehead (HP:0000340)2.45395297
60Sclerocornea (HP:0000647)2.44349658
61Rhabdomyosarcoma (HP:0002859)2.41800587
62Lymphoma (HP:0002665)2.41495528
63Meckel diverticulum (HP:0002245)2.40767384
64Hypoplasia of the thymus (HP:0000778)2.39597378
65Embryonal renal neoplasm (HP:0011794)2.38013312
66Impulsivity (HP:0100710)2.36603567
67Abnormality of the renal collecting system (HP:0004742)2.34901615
68Ectopic kidney (HP:0000086)2.33964497
69Abnormal respiratory motile cilium physiology (HP:0012261)2.31729161
70Aplasia/Hypoplasia of the tibia (HP:0005772)2.30767508
71Abnormal trabecular bone morphology (HP:0100671)2.30720836
72Short middle phalanx of the 5th finger (HP:0004220)2.29778235
73Cellulitis (HP:0100658)2.29031625
74Abnormality of the ileum (HP:0001549)2.28334045
75Methylmalonic acidemia (HP:0002912)2.28262787
76Thyroiditis (HP:0100646)2.27974684
77Type 2 muscle fiber atrophy (HP:0003554)2.27233102
78Decreased central vision (HP:0007663)2.27144441
79Bony spicule pigmentary retinopathy (HP:0007737)2.25290386
80Tubular atrophy (HP:0000092)2.25211462
81Panhypogammaglobulinemia (HP:0003139)2.24056853
82Abnormal rod and cone electroretinograms (HP:0008323)2.23676377
83Recurrent viral infections (HP:0004429)2.20965977
84Abnormality of B cell number (HP:0010975)2.20605805
85B lymphocytopenia (HP:0010976)2.20605805
86Volvulus (HP:0002580)2.19875682
87Neoplasm of the pancreas (HP:0002894)2.18462259
88Aplasia/Hypoplasia of the uvula (HP:0010293)2.17829157
89Squamous cell carcinoma (HP:0002860)2.13051438
90Absent rod-and cone-mediated responses on ERG (HP:0007688)2.12148342
91Abnormal biliary tract physiology (HP:0012439)2.11894207
92Bile duct proliferation (HP:0001408)2.11894207
93Aplasia/Hypoplasia of the tongue (HP:0010295)2.11238904
94Abnormality of the nasal septum (HP:0000419)2.10920252
95Thrombocytosis (HP:0001894)2.10903802
96Small intestinal stenosis (HP:0012848)2.10702006
97Duodenal stenosis (HP:0100867)2.10702006
98Hyperglycinemia (HP:0002154)2.10667313
99Methylmalonic aciduria (HP:0012120)2.10145779
100Carpal bone hypoplasia (HP:0001498)2.10063044
101Muscle fiber atrophy (HP:0100295)2.09728341
102Renal cortical cysts (HP:0000803)2.09160989
103Chorioretinal atrophy (HP:0000533)2.08638788
104Pancytopenia (HP:0001876)2.08382459
105Increased corneal curvature (HP:0100692)2.07922456
106Keratoconus (HP:0000563)2.07922456
107Patellar aplasia (HP:0006443)2.06334217
108Hyperventilation (HP:0002883)2.05451853
109Postaxial foot polydactyly (HP:0001830)2.05263185
110Furrowed tongue (HP:0000221)2.04858608
111IgG deficiency (HP:0004315)2.04313363
112Anencephaly (HP:0002323)2.03752179
113Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.03705918
114Absent thumb (HP:0009777)2.03392223
115Abnormality of the proximal phalanges of the hand (HP:0009834)2.03123632
116Azoospermia (HP:0000027)2.00110355
117Recurrent bronchitis (HP:0002837)2.00100024
118Amyotrophic lateral sclerosis (HP:0007354)1.98994249
119Stomach cancer (HP:0012126)1.98289372
120Congenital hepatic fibrosis (HP:0002612)1.97337711
121Poikiloderma (HP:0001029)1.97058226
122Polydipsia (HP:0001959)1.96298248
123Abnormal drinking behavior (HP:0030082)1.96298248
124Prominent nose (HP:0000448)1.96098696
125Type II lissencephaly (HP:0007260)1.95294697
126Severe combined immunodeficiency (HP:0004430)1.94412228
127Entropion (HP:0000621)1.93396213
128Aplasia/Hypoplasia of the sternum (HP:0006714)1.93386427
129Small hand (HP:0200055)1.93201878
130Supernumerary bones of the axial skeleton (HP:0009144)1.92880217
131Male pseudohermaphroditism (HP:0000037)1.92195398
132Congenital primary aphakia (HP:0007707)1.91722279
133Amaurosis fugax (HP:0100576)1.91339493
134Clubbing of toes (HP:0100760)1.91206315
135Abnormal number of incisors (HP:0011064)1.90759252
136Breast hypoplasia (HP:0003187)1.90131890
137Duplicated collecting system (HP:0000081)1.89899830
138Abnormality of DNA repair (HP:0003254)1.89358688
139Self-mutilation (HP:0000742)1.89222027
140Rhinitis (HP:0012384)1.89138846
141Abnormal respiratory epithelium morphology (HP:0012253)1.89065543
142Abnormal respiratory motile cilium morphology (HP:0005938)1.89065543
143Gait imbalance (HP:0002141)1.88495640
144Abnormality of the prostate (HP:0008775)1.88248547
145Macrocytic anemia (HP:0001972)1.87204735
146Short hallux (HP:0010109)1.87107967
147Facial hemangioma (HP:0000329)1.86447276
148Basal cell carcinoma (HP:0002671)1.86064234
149Increased nuchal translucency (HP:0010880)1.85668518
150Tracheoesophageal fistula (HP:0002575)1.84582536
151Absent/shortened dynein arms (HP:0200106)1.83532263
152Dynein arm defect of respiratory motile cilia (HP:0012255)1.83532263
153Aplasia/Hypoplasia of the patella (HP:0006498)1.83261829
154Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.82470271
155Short 1st metacarpal (HP:0010034)1.82470271
156Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.82263954
157Genital tract atresia (HP:0001827)1.81132281
158Abnormality of the phalanges of the 2nd finger (HP:0009541)1.81081036
159Freckling (HP:0001480)1.80973121
160Congenital sensorineural hearing impairment (HP:0008527)1.79659739
161Abnormality of the middle phalanges of the toes (HP:0010183)1.77909667
162Inability to walk (HP:0002540)1.77887935
163Vaginal atresia (HP:0000148)1.76923269
164Aplasia/Hypoplasia of the hallux (HP:0008362)1.76540936
165Supernumerary ribs (HP:0005815)1.76388883
166Abnormality of the carotid arteries (HP:0005344)1.76162468
167Cerebral hypomyelination (HP:0006808)1.75625028
168Neoplasm of the colon (HP:0100273)1.75514293
169Hyperglycinuria (HP:0003108)1.75402751
170Pallor (HP:0000980)1.75194694
1713-Methylglutaconic aciduria (HP:0003535)1.74016915
172Preaxial hand polydactyly (HP:0001177)1.74006887
173Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.73939077
174Abnormality of the duodenum (HP:0002246)1.73160417
175Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72962139
176Decreased electroretinogram (ERG) amplitude (HP:0000654)1.72863496
177Abnormality of glycine metabolism (HP:0010895)1.72222790
178Abnormality of serine family amino acid metabolism (HP:0010894)1.72222790
179Agammaglobulinemia (HP:0004432)1.71638560
180Oligohydramnios (HP:0001562)1.71511540

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.74090270
2CDC74.09886498
3WEE13.82196417
4BUB13.79039847
5NEK23.46927805
6ACVR1B3.39321019
7BMPR1B3.25003434
8PLK42.91083169
9EIF2AK12.84960276
10ADRBK22.53855514
11GRK12.47684687
12BCKDK2.40113058
13EIF2AK32.38913451
14SRPK12.32568765
15BRSK22.29962601
16TTK2.09793815
17MAP4K22.05331480
18VRK12.03115155
19MKNK11.99539089
20INSRR1.98898717
21MAP4K11.98381467
22WNK31.96166412
23ATR1.95350717
24STK161.92356620
25CCNB11.85784441
26TSSK61.81458710
27TAOK31.81139234
28PLK11.78955029
29WNK41.71977087
30AURKB1.71046834
31MKNK21.65084441
32PINK11.52379477
33PLK31.50231529
34IRAK31.49094919
35PDK31.42806905
36PDK41.42806905
37IRAK41.40987137
38OXSR11.39375986
39MAPK131.39243414
40TNIK1.38947267
41CHEK21.33239374
42RPS6KA41.33070550
43CDK121.29031004
44STK391.26974925
45PLK21.25182403
46DYRK31.24390895
47MAP3K41.23804963
48CHEK11.21265706
49CASK1.18359897
50STK41.17984986
51NME21.16910258
52CDK71.11578117
53TLK11.10840973
54BRSK11.09706905
55PASK1.07975056
56TGFBR11.07349845
57RPS6KB21.07338050
58PNCK1.06991736
59ATM1.05799288
60NEK11.04612574
61STK38L1.03745745
62PIM11.03014591
63STK100.99374953
64KIT0.98666145
65CDK40.98034247
66BRD40.95651646
67JAK30.92366752
68TEC0.90437276
69ADRBK10.89243516
70NLK0.88507549
71FLT30.87727690
72MAP3K80.85361712
73MAPKAPK30.84408908
74EIF2AK20.82799765
75PRKCE0.79859834
76TXK0.78434675
77* CDK20.76938761
78PRKCG0.75414433
79MAP3K100.75382719
80SIK30.74455082
81NUAK10.74410604
82CSF1R0.73709501
83BTK0.71802786
84AURKA0.71603904
85DYRK20.71467508
86MAPK150.71212196
87STK30.69925796
88ZAK0.69359537
89SCYL20.69044243
90MARK30.68002187
91MAP3K60.65911151
92* CDK10.65073914
93CSNK2A20.64320158
94CSNK2A10.64271174
95NTRK30.63891686
96FGFR20.63221358
97MAP2K30.62939697
98YES10.62198502
99VRK20.62183192
100DAPK20.60786472
101PAK30.60604862
102LATS10.60205611
103MAP2K60.59861408
104TIE10.59689683
105CSNK1G10.57435028
106CSNK1G20.55222849
107ERBB20.54808083
108AKT30.54405648
109RPS6KB10.54132781
110PAK40.53346844
111MELK0.52309483
112SGK20.51361321
113ZAP700.51282980
114TAF10.48815122
115IKBKB0.47860745
116CDK60.47625609
117CAMK2A0.43975187
118CSNK1A1L0.43877949
119CLK10.43809229
120GRK60.41558431
121CSNK1A10.41276807
122DAPK10.41055153
123CDK190.40715290
124PRKCQ0.40677180
125CDK30.39661206
126PTK2B0.39639290
127PDK20.39277840
128MAPKAPK50.38747430
129SYK0.37893565
130RPS6KA50.37563137
131PRKACA0.37362712
132ITK0.37316032
133NME10.37067043
134PRKAA10.36279781
135CSNK1G30.35899764
136CSNK1D0.35525468
137STK110.34817281
138PIK3CA0.33830550
139SIK20.33814842
140ALK0.33664189
141PRKAA20.33601808
142LYN0.33365494
143TNK20.33110861
144SGK10.32997181
145TRIM280.32439682
146EPHA30.32163292
147PIK3CG0.31601568
148WNK10.31432620
149OBSCN0.31147412
150PRKCI0.29313586
151PRKDC0.29232180
152TYK20.28854865
153LCK0.28216663
154CHUK0.28140215
155MAPK140.27576789
156LRRK20.27451707
157CDK80.27425627
158MST40.27268873
159RPS6KC10.27224115
160RPS6KL10.27224115
161TESK20.27071095
162RPS6KA60.26861399

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.83926385
2Mismatch repair_Homo sapiens_hsa034304.48094957
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.83664276
4RNA polymerase_Homo sapiens_hsa030203.30619670
5Spliceosome_Homo sapiens_hsa030403.30290357
6Homologous recombination_Homo sapiens_hsa034403.24911841
7RNA transport_Homo sapiens_hsa030133.16333136
8Base excision repair_Homo sapiens_hsa034103.12674144
9Proteasome_Homo sapiens_hsa030502.81960245
10Fanconi anemia pathway_Homo sapiens_hsa034602.77453889
11Nucleotide excision repair_Homo sapiens_hsa034202.77331900
12Ribosome_Homo sapiens_hsa030102.66307319
13Cell cycle_Homo sapiens_hsa041102.58804764
14One carbon pool by folate_Homo sapiens_hsa006702.54023506
15Pyrimidine metabolism_Homo sapiens_hsa002402.51579114
16Non-homologous end-joining_Homo sapiens_hsa034502.45945345
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.41789053
18RNA degradation_Homo sapiens_hsa030182.39239374
19Phototransduction_Homo sapiens_hsa047442.38375545
20Basal transcription factors_Homo sapiens_hsa030222.28330804
21Nitrogen metabolism_Homo sapiens_hsa009102.14800380
22Nicotine addiction_Homo sapiens_hsa050332.08875605
23Butanoate metabolism_Homo sapiens_hsa006501.95827353
24Linoleic acid metabolism_Homo sapiens_hsa005911.95613677
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.86889569
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.84525758
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.79597063
28Caffeine metabolism_Homo sapiens_hsa002321.77851733
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.77696090
30mRNA surveillance pathway_Homo sapiens_hsa030151.76227140
31Tryptophan metabolism_Homo sapiens_hsa003801.74688542
32Propanoate metabolism_Homo sapiens_hsa006401.74315312
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.73616680
34Retinol metabolism_Homo sapiens_hsa008301.69312292
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.68472536
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.66707354
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.61968963
38Purine metabolism_Homo sapiens_hsa002301.58787326
39Chemical carcinogenesis_Homo sapiens_hsa052041.58686795
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.57323942
41Taste transduction_Homo sapiens_hsa047421.56357111
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.55521221
43Olfactory transduction_Homo sapiens_hsa047401.55471806
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.50447405
45Primary bile acid biosynthesis_Homo sapiens_hsa001201.44256763
46Primary immunodeficiency_Homo sapiens_hsa053401.42453114
47p53 signaling pathway_Homo sapiens_hsa041151.31245011
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.28065677
49Epstein-Barr virus infection_Homo sapiens_hsa051691.27891996
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.26910970
51Herpes simplex infection_Homo sapiens_hsa051681.17741057
52Systemic lupus erythematosus_Homo sapiens_hsa053221.17275523
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.17101008
54Antigen processing and presentation_Homo sapiens_hsa046121.16824455
55Selenocompound metabolism_Homo sapiens_hsa004501.13068404
56Ether lipid metabolism_Homo sapiens_hsa005651.12949124
57ABC transporters_Homo sapiens_hsa020101.12103253
58Morphine addiction_Homo sapiens_hsa050321.10133398
59Pentose and glucuronate interconversions_Homo sapiens_hsa000401.09889707
60Oocyte meiosis_Homo sapiens_hsa041141.08555140
61Histidine metabolism_Homo sapiens_hsa003401.07609358
62Oxidative phosphorylation_Homo sapiens_hsa001901.06625986
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.04783652
64Vitamin B6 metabolism_Homo sapiens_hsa007501.04045831
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.03622108
66Glycerolipid metabolism_Homo sapiens_hsa005611.03311882
67Cysteine and methionine metabolism_Homo sapiens_hsa002701.02830714
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.02334334
69Peroxisome_Homo sapiens_hsa041460.91021295
70Pentose phosphate pathway_Homo sapiens_hsa000300.90569300
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.90039958
72Fat digestion and absorption_Homo sapiens_hsa049750.87970039
73Viral carcinogenesis_Homo sapiens_hsa052030.84200807
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80061489
75Vitamin digestion and absorption_Homo sapiens_hsa049770.79655626
76Sulfur metabolism_Homo sapiens_hsa009200.79241123
77beta-Alanine metabolism_Homo sapiens_hsa004100.76637798
78Fatty acid biosynthesis_Homo sapiens_hsa000610.76618186
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76423324
80Dorso-ventral axis formation_Homo sapiens_hsa043200.75915110
81Circadian entrainment_Homo sapiens_hsa047130.75056748
82Protein export_Homo sapiens_hsa030600.73701687
83Serotonergic synapse_Homo sapiens_hsa047260.73270464
84Sulfur relay system_Homo sapiens_hsa041220.72865810
85HTLV-I infection_Homo sapiens_hsa051660.72540470
86GABAergic synapse_Homo sapiens_hsa047270.71448465
87Fatty acid degradation_Homo sapiens_hsa000710.69285560
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68881714
89Glutamatergic synapse_Homo sapiens_hsa047240.68214024
90Measles_Homo sapiens_hsa051620.67947399
91Arachidonic acid metabolism_Homo sapiens_hsa005900.65904008
92Biosynthesis of amino acids_Homo sapiens_hsa012300.65594645
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64158915
94Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63455115
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62319096
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.62288256
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60972702
98NF-kappa B signaling pathway_Homo sapiens_hsa040640.58120067
99Folate biosynthesis_Homo sapiens_hsa007900.57458618
100Salivary secretion_Homo sapiens_hsa049700.56386172
101Regulation of autophagy_Homo sapiens_hsa041400.55977645
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55157104
103Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55028928
104Calcium signaling pathway_Homo sapiens_hsa040200.54864688
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53922152
106Legionellosis_Homo sapiens_hsa051340.49420937
107Insulin secretion_Homo sapiens_hsa049110.49203550
108Hematopoietic cell lineage_Homo sapiens_hsa046400.48475354
109Influenza A_Homo sapiens_hsa051640.46897043
110Cardiac muscle contraction_Homo sapiens_hsa042600.46134728
111B cell receptor signaling pathway_Homo sapiens_hsa046620.45468626
112Alzheimers disease_Homo sapiens_hsa050100.44485641
113Ovarian steroidogenesis_Homo sapiens_hsa049130.44032942
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42373209
115Apoptosis_Homo sapiens_hsa042100.42054529
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41458047
117Huntingtons disease_Homo sapiens_hsa050160.41186675
118Starch and sucrose metabolism_Homo sapiens_hsa005000.40309328
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39899435
120NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39166646
121Small cell lung cancer_Homo sapiens_hsa052220.39165075
122Hedgehog signaling pathway_Homo sapiens_hsa043400.38575643
123Carbon metabolism_Homo sapiens_hsa012000.33347447
124Thyroid cancer_Homo sapiens_hsa052160.32718949
125MicroRNAs in cancer_Homo sapiens_hsa052060.32665865
126Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.30912850
127Hepatitis B_Homo sapiens_hsa051610.28763844
128RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28098811
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27322590
130Renin-angiotensin system_Homo sapiens_hsa046140.26475130
131Glutathione metabolism_Homo sapiens_hsa004800.26338995
132N-Glycan biosynthesis_Homo sapiens_hsa005100.26327716
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26291555
134Cyanoamino acid metabolism_Homo sapiens_hsa004600.24788567
135Acute myeloid leukemia_Homo sapiens_hsa052210.24459120
136Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.23509971
137Colorectal cancer_Homo sapiens_hsa052100.23243590
138Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.22754827
139Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.22469091
140Lysine degradation_Homo sapiens_hsa003100.22129503
141Leishmaniasis_Homo sapiens_hsa051400.22097593
142Metabolic pathways_Homo sapiens_hsa011000.21829869
143Alcoholism_Homo sapiens_hsa050340.20430395
144Fructose and mannose metabolism_Homo sapiens_hsa000510.18267199
145Shigellosis_Homo sapiens_hsa051310.17025097
146Parkinsons disease_Homo sapiens_hsa050120.16795973
147T cell receptor signaling pathway_Homo sapiens_hsa046600.16589066
148Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.15785852
149Allograft rejection_Homo sapiens_hsa053300.15737576
150Jak-STAT signaling pathway_Homo sapiens_hsa046300.14590849
151Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.13000096
152Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.11979598
153Viral myocarditis_Homo sapiens_hsa054160.11960872
154HIF-1 signaling pathway_Homo sapiens_hsa040660.11091223
155Non-small cell lung cancer_Homo sapiens_hsa052230.10768504
156Central carbon metabolism in cancer_Homo sapiens_hsa052300.09439735
157Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.09360998
158FoxO signaling pathway_Homo sapiens_hsa040680.08893678
159Platelet activation_Homo sapiens_hsa046110.08281466
160Pathways in cancer_Homo sapiens_hsa052000.08241681
161Graft-versus-host disease_Homo sapiens_hsa053320.08175081
162Asthma_Homo sapiens_hsa053100.07765355

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