FGFR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endocardial cushion morphogenesis (GO:0003203)6.83177238
2regulation of somitogenesis (GO:0014807)6.25186756
3heart valve formation (GO:0003188)6.12716937
4epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)5.88756871
5Notch signaling involved in heart development (GO:0061314)5.49379599
6negative regulation of oligodendrocyte differentiation (GO:0048715)5.37033136
7desmosome organization (GO:0002934)5.36357950
8neuron projection extension involved in neuron projection guidance (GO:1902284)5.22691840
9axon extension involved in axon guidance (GO:0048846)5.22691840
10midgut development (GO:0007494)5.12214101
11collecting duct development (GO:0072044)5.12213311
12neuronal stem cell maintenance (GO:0097150)4.92101539
13mesenchyme morphogenesis (GO:0072132)4.89247681
14epithelial cell differentiation involved in prostate gland development (GO:0060742)4.86220043
15somite development (GO:0061053)4.79671676
16establishment of skin barrier (GO:0061436)4.74862497
17mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.67263616
18atrioventricular valve morphogenesis (GO:0003181)4.66340489
19cellular response to cholesterol (GO:0071397)4.65024447
20positive regulation of astrocyte differentiation (GO:0048711)4.65000380
21regulation of extracellular matrix organization (GO:1903053)4.59227500
22coronary vasculature morphogenesis (GO:0060977)4.46589569
23cell migration involved in heart development (GO:0060973)4.32609946
24venous blood vessel morphogenesis (GO:0048845)4.32126777
25ventricular trabecula myocardium morphogenesis (GO:0003222)4.27551071
26* lung epithelium development (GO:0060428)4.27513446
27regulation of water loss via skin (GO:0033561)4.26528454
28negative regulation of calcium ion-dependent exocytosis (GO:0045955)4.25552059
29negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.25263027
30cellular response to follicle-stimulating hormone stimulus (GO:0071372)4.18285085
31regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)4.16773783
32heart trabecula morphogenesis (GO:0061384)4.09105574
33nephron tubule development (GO:0072080)4.09103734
34regulation of endothelial cell chemotaxis (GO:2001026)4.07240084
35regulation of cholesterol homeostasis (GO:2000188)4.07191732
36exocrine pancreas development (GO:0031017)4.02434877
37cardiac left ventricle morphogenesis (GO:0003214)3.97086916
38* lens fiber cell development (GO:0070307)3.94768941
39cellular response to sterol (GO:0036315)3.91986021
40very-low-density lipoprotein particle assembly (GO:0034379)3.86361074
41positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.84768225
42plasma lipoprotein particle assembly (GO:0034377)3.82672037
43regulation of cholesterol biosynthetic process (GO:0045540)3.80481072
44proline metabolic process (GO:0006560)3.77166175
45multicellular organismal water homeostasis (GO:0050891)3.76759802
46planar cell polarity pathway involved in neural tube closure (GO:0090179)3.75913433
47renal system development (GO:0072001)3.75816969
48positive regulation of synapse maturation (GO:0090129)3.73451376
49* regulation of astrocyte differentiation (GO:0048710)3.69571309
50negative regulation of fibrinolysis (GO:0051918)3.65316508
51peptidyl-glutamic acid carboxylation (GO:0017187)3.64800153
52protein carboxylation (GO:0018214)3.64800153
53positive regulation of extracellular matrix organization (GO:1903055)3.58308506
54renal tubule development (GO:0061326)3.55499293
55regulation of cholesterol esterification (GO:0010872)3.50975334
56keratinization (GO:0031424)3.49589924
57protein-lipid complex assembly (GO:0065005)3.48296230
58* negative regulation of astrocyte differentiation (GO:0048712)3.45408598
59negative regulation of glial cell proliferation (GO:0060253)3.45230589
60regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.41400439
61* negative regulation of glial cell differentiation (GO:0045686)3.41078236
62synaptic vesicle docking involved in exocytosis (GO:0016081)3.37661094
63somatic stem cell division (GO:0048103)3.36827171
64* epithelial cell fate commitment (GO:0072148)3.36651741
65thalamus development (GO:0021794)3.35980319
66embryonic camera-type eye development (GO:0031076)3.35569568
67notochord development (GO:0030903)3.30473702
68positive regulation of neuroblast proliferation (GO:0002052)3.25192789
69dorsal/ventral neural tube patterning (GO:0021904)3.24643855
70cardiac muscle cell proliferation (GO:0060038)3.22667020
71embryonic viscerocranium morphogenesis (GO:0048703)3.22539035
72intestinal cholesterol absorption (GO:0030299)3.22004319
73regulation of synapse maturation (GO:0090128)3.21972060
74glutamate secretion (GO:0014047)3.21898341
75neurotransmitter-gated ion channel clustering (GO:0072578)3.21825979
76protein-lipid complex remodeling (GO:0034368)3.21728857
77macromolecular complex remodeling (GO:0034367)3.21728857
78plasma lipoprotein particle remodeling (GO:0034369)3.21728857
79cell-cell junction maintenance (GO:0045217)3.21603765
80type B pancreatic cell development (GO:0003323)3.21268395
81negative regulation of cholesterol transport (GO:0032375)3.20761311
82negative regulation of sterol transport (GO:0032372)3.20761311
83high-density lipoprotein particle remodeling (GO:0034375)3.19993641
84alanine transport (GO:0032328)3.19778162
85nephron epithelium development (GO:0072009)3.18970049
86positive regulation of dendritic spine morphogenesis (GO:0061003)3.18624693
87trabecula morphogenesis (GO:0061383)3.18291919
88myoblast migration (GO:0051451)3.17539555
89negative regulation of osteoblast proliferation (GO:0033689)3.17363691
90lateral sprouting from an epithelium (GO:0060601)3.16675350
91regulation of bile acid biosynthetic process (GO:0070857)3.16613226
92low-density lipoprotein particle remodeling (GO:0034374)3.13869977
93negative regulation of chondrocyte differentiation (GO:0032331)3.11793665
94regulation of fibrinolysis (GO:0051917)3.11325496
95glutamate metabolic process (GO:0006536)3.11022873
96regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.09463625
97proline biosynthetic process (GO:0006561)3.08438423
98regulation of apoptotic cell clearance (GO:2000425)3.05552900
99left/right axis specification (GO:0070986)3.05288880
100water homeostasis (GO:0030104)3.05127191
101cerebellar granule cell differentiation (GO:0021707)3.05048156
102cell surface receptor signaling pathway involved in heart development (GO:0061311)3.04729864
103layer formation in cerebral cortex (GO:0021819)3.03769791
104reverse cholesterol transport (GO:0043691)2.99759033
105locomotory exploration behavior (GO:0035641)2.99538612
106embryonic retina morphogenesis in camera-type eye (GO:0060059)2.99429304
107heart valve morphogenesis (GO:0003179)2.99422265
108alpha-linolenic acid metabolic process (GO:0036109)2.98860668
109sodium ion homeostasis (GO:0055078)2.98273566
110L-amino acid import (GO:0043092)2.97369718
111cytoskeletal anchoring at plasma membrane (GO:0007016)2.96931926
112cardiac epithelial to mesenchymal transition (GO:0060317)2.95840510
113regulation of protein activation cascade (GO:2000257)2.94777263
114triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.92752296
115plasma lipoprotein particle organization (GO:0071827)2.92002351
116positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.91870095
117cholesterol efflux (GO:0033344)2.91840047
118negative regulation of myoblast differentiation (GO:0045662)2.90687595
119* central nervous system myelination (GO:0022010)2.90516075
120* axon ensheathment in central nervous system (GO:0032291)2.90516075
121keratinocyte proliferation (GO:0043616)2.90448913
122limb bud formation (GO:0060174)2.88614137
123phospholipid efflux (GO:0033700)2.88140149
124regulation of complement activation (GO:0030449)2.86996186
125lung-associated mesenchyme development (GO:0060484)2.86411134
126barbed-end actin filament capping (GO:0051016)2.84288761
127positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.83537543
128striated muscle cell proliferation (GO:0014855)2.83400325
129mammary gland epithelial cell differentiation (GO:0060644)2.82171752
130protein-lipid complex subunit organization (GO:0071825)2.78747044
131potassium ion homeostasis (GO:0055075)2.78240459
132Notch receptor processing (GO:0007220)2.77446785
133response to follicle-stimulating hormone (GO:0032354)2.74737468
134regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.74482450
135sodium ion export (GO:0071436)2.73465901
136negative regulation of catenin import into nucleus (GO:0035414)2.72790522
137regulation of cholesterol metabolic process (GO:0090181)2.72304121
138respiratory tube development (GO:0030323)2.72194274
139negative regulation of myotube differentiation (GO:0010832)2.71922532
140* negative regulation of smoothened signaling pathway (GO:0045879)2.71731841
141regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.69815748
142renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.69209808
143gamma-aminobutyric acid transport (GO:0015812)2.67927963
144response to muramyl dipeptide (GO:0032495)2.67819294
145amino acid import (GO:0043090)2.67512776
146neuroblast proliferation (GO:0007405)2.67428818
147muscle cell fate commitment (GO:0042693)2.66276888
148positive regulation of steroid metabolic process (GO:0045940)2.65668886
149Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.65142258
150endothelial cell differentiation (GO:0045446)2.62811245
151response to cholesterol (GO:0070723)2.62680333
152cochlea morphogenesis (GO:0090103)2.61787211
153glutamine family amino acid biosynthetic process (GO:0009084)2.60904839
154astrocyte differentiation (GO:0048708)2.60799669
155cell junction maintenance (GO:0034331)2.60726897
156cellular potassium ion homeostasis (GO:0030007)2.60641122
157bundle of His cell to Purkinje myocyte communication (GO:0086069)2.60363489
158ventricular septum morphogenesis (GO:0060412)2.59488923
159establishment of planar polarity (GO:0001736)2.59303353
160establishment of tissue polarity (GO:0007164)2.59303353
161regulation of oligodendrocyte differentiation (GO:0048713)2.59231870
162nephron epithelium morphogenesis (GO:0072088)2.58673917
163nephron tubule morphogenesis (GO:0072078)2.58673917
164negative regulation of lipase activity (GO:0060192)2.58640002
165hair follicle morphogenesis (GO:0031069)2.57509740
166regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.56528167
167cellular sodium ion homeostasis (GO:0006883)2.56523149
168C4-dicarboxylate transport (GO:0015740)2.55926190
169muscle cell proliferation (GO:0033002)2.55748666
170regulation of neuronal synaptic plasticity (GO:0048168)2.54040801
171dicarboxylic acid biosynthetic process (GO:0043650)2.52670317
172L-phenylalanine catabolic process (GO:0006559)2.51629734
173erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.51629734
174positive regulation of dendritic spine development (GO:0060999)2.50900240
175regulation of short-term neuronal synaptic plasticity (GO:0048172)2.50433530
176G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.48987577
177regulation of establishment of planar polarity (GO:0090175)2.48950486
178one-carbon compound transport (GO:0019755)2.48350131
179apical protein localization (GO:0045176)2.47038672
180regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.46706230
181synaptic vesicle maturation (GO:0016188)2.45342346
182vocalization behavior (GO:0071625)2.44484492
183L-phenylalanine metabolic process (GO:0006558)2.43375790
184erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.43375790
185neurotransmitter secretion (GO:0007269)2.43126590

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.02014029
2* EZH2_18974828_ChIP-Seq_MESCs_Mouse3.05055821
3* RNF2_18974828_ChIP-Seq_MESCs_Mouse3.05055821
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.01372914
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.89887019
6* EED_16625203_ChIP-ChIP_MESCs_Mouse2.75330116
7* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.72298320
8EZH2_22144423_ChIP-Seq_EOC_Human2.69591960
9* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.61017915
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.60092985
11* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.58647253
12* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.55088197
13* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.54118533
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.51902254
15* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45375015
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.30155229
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.28901191
18ZNF263_19887448_ChIP-Seq_K562_Human2.25001072
19* RNF2_27304074_Chip-Seq_ESCs_Mouse2.24234020
20* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.19855267
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.16470175
22DROSHA_22980978_ChIP-Seq_HELA_Human2.15906518
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13568173
24ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.11587390
25AR_21572438_ChIP-Seq_LNCaP_Human2.02062619
26* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.00422229
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92359339
28* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.92160599
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.83871330
30ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.82361120
31* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.81408830
32* CBX2_27304074_Chip-Seq_ESCs_Mouse1.73195905
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.72812160
34RACK7_27058665_Chip-Seq_MCF-7_Human1.71367220
35GBX2_23144817_ChIP-Seq_PC3_Human1.70899670
36RING1B_27294783_Chip-Seq_ESCs_Mouse1.69167442
37* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68930986
38* TP53_20018659_ChIP-ChIP_R1E_Mouse1.59824358
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.58943321
40RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.58890305
41FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.51488527
42SMC4_20622854_ChIP-Seq_HELA_Human1.48987285
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.46487949
44EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.44955764
45UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.43184566
46CREB1_26743006_Chip-Seq_LNCaP_Human1.43121465
47PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.41677163
48CLOCK_20551151_ChIP-Seq_293T_Human1.38398502
49* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.35436705
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35002921
51* CDX2_20551321_ChIP-Seq_CACO-2_Human1.34855971
52* RXR_22158963_ChIP-Seq_LIVER_Mouse1.33007820
53REST_21632747_ChIP-Seq_MESCs_Mouse1.31670948
54RUNX1_27514584_Chip-Seq_MCF-7_Human1.30844798
55P68_20966046_ChIP-Seq_HELA_Human1.28704432
56P63_26484246_Chip-Seq_KERATINOCYTES_Human1.28524734
57* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27961153
58THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26738650
59SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25834477
60LXR_22158963_ChIP-Seq_LIVER_Mouse1.25257302
61ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.25134618
62CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.24514773
63WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24012253
64CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.22851831
65ESR1_15608294_ChIP-ChIP_MCF-7_Human1.22279791
66DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22186513
67TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.21386806
68TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.19987363
69RING1B_27294783_Chip-Seq_NPCs_Mouse1.19387262
70POU5F1_16518401_ChIP-PET_MESCs_Mouse1.17450357
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15894746
72PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15407935
73TP53_18474530_ChIP-ChIP_U2OS_Human1.15107741
74SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13594897
75RARB_27405468_Chip-Seq_BRAIN_Mouse1.13570926
76* TP63_22573176_ChIP-Seq_HFKS_Human1.11910719
77TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10607900
78IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09558436
79BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09521866
80SA1_27219007_Chip-Seq_ERYTHROID_Human1.09463328
81SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09044437
82ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08360996
83FOXO3_23340844_ChIP-Seq_DLD1_Human1.07818405
84NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.07327602
85* KDM2B_26808549_Chip-Seq_K562_Human1.06967467
86CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06480722
87ESR1_21235772_ChIP-Seq_MCF-7_Human1.04490076
88SOX2_27498859_Chip-Seq_STOMACH_Mouse1.04437999
89KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04407112
90BCAT_22108803_ChIP-Seq_LS180_Human1.04242627
91CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04036157
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.03248581
93* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03213693
94CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02252746
95* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.02232144
96RXR_22108803_ChIP-Seq_LS180_Human0.99707669
97GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.97767784
98REST_18959480_ChIP-ChIP_MESCs_Mouse0.97628042
99SOX2_21211035_ChIP-Seq_LN229_Gbm0.96674793
100* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.96171133
101NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95642864
102STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.95273221
103ZFP281_18757296_ChIP-ChIP_E14_Mouse0.94826329
104* HNF4A_19822575_ChIP-Seq_HepG2_Human0.94655268
105NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94319412
106NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94016103
107KDM2B_26808549_Chip-Seq_DND41_Human0.93952823
108SMAD3_21741376_ChIP-Seq_EPCs_Human0.93737125
109ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93249365
110CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92837507
111TP53_16413492_ChIP-PET_HCT116_Human0.92830530
112SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.92255395
113SMAD_19615063_ChIP-ChIP_OVARY_Human0.92016929
114NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.91843988
115SMAD4_21799915_ChIP-Seq_A2780_Human0.91784767
116AR_25329375_ChIP-Seq_VCAP_Human0.91699006
117CTCF_27219007_Chip-Seq_Bcells_Human0.91288582
118NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.91250264
119SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90976395
120LXR_22292898_ChIP-Seq_THP-1_Human0.89532641
121SMAD3_21741376_ChIP-Seq_HESCs_Human0.89429324
122ZFP281_27345836_Chip-Seq_ESCs_Mouse0.89094839
123* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88344066
124ARNT_22903824_ChIP-Seq_MCF-7_Human0.85336610
125SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.84471170
126AR_19668381_ChIP-Seq_PC3_Human0.82604506
127AHR_22903824_ChIP-Seq_MCF-7_Human0.82220072
128SMAD4_21741376_ChIP-Seq_HESCs_Human0.81655190
129* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.81282274
130FOXA2_19822575_ChIP-Seq_HepG2_Human0.79694441
131TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78940065
132ISL1_27105846_Chip-Seq_CPCs_Mouse0.77106438
133RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.75747328
134* EP300_21415370_ChIP-Seq_HL-1_Mouse0.74591922
135YAP1_20516196_ChIP-Seq_MESCs_Mouse0.72789771
136CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.71860487
137TET1_21490601_ChIP-Seq_MESCs_Mouse0.71533545
138P300_19829295_ChIP-Seq_ESCs_Human0.71340929
139MYC_27129775_Chip-Seq_CORNEA_Mouse0.70808326

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern7.33022822
2MP0005423_abnormal_somatic_nervous7.01693513
3MP0010030_abnormal_orbit_morphology5.71091503
4MP0002249_abnormal_larynx_morphology3.15790358
5MP0003122_maternal_imprinting2.88331369
6MP0004381_abnormal_hair_follicle2.64126673
7* MP0000566_synostosis2.56119740
8MP0002102_abnormal_ear_morphology2.49075139
9MP0003283_abnormal_digestive_organ2.44444505
10MP0003941_abnormal_skin_development2.43544368
11MP0005257_abnormal_intraocular_pressure2.36112837
12MP0004859_abnormal_synaptic_plasticity2.32375736
13MP0009379_abnormal_foot_pigmentation2.23331559
14MP0005409_darkened_coat_color2.14241916
15MP0003136_yellow_coat_color2.05236763
16MP0006276_abnormal_autonomic_nervous2.03427921
17MP0003183_abnormal_peptide_metabolism1.93821911
18MP0004264_abnormal_extraembryonic_tissu1.93023022
19MP0000762_abnormal_tongue_morphology1.92265029
20MP0000647_abnormal_sebaceous_gland1.90926934
21MP0000579_abnormal_nail_morphology1.88569964
22MP0002139_abnormal_hepatobiliary_system1.88096800
23MP0005501_abnormal_skin_physiology1.82540829
24MP0003705_abnormal_hypodermis_morpholog1.82046668
25MP0002098_abnormal_vibrissa_morphology1.81936882
26MP0001666_abnormal_nutrient_absorption1.80716360
27MP0000778_abnormal_nervous_system1.74821295
28MP0005646_abnormal_pituitary_gland1.70985009
29MP0000537_abnormal_urethra_morphology1.66336410
30MP0003938_abnormal_ear_development1.65843514
31MP0004885_abnormal_endolymph1.58799523
32MP0003123_paternal_imprinting1.58783442
33MP0004858_abnormal_nervous_system1.54170537
34MP0001486_abnormal_startle_reflex1.53320566
35MP0005360_urolithiasis1.52245561
36MP0003878_abnormal_ear_physiology1.50667505
37MP0005377_hearing/vestibular/ear_phenot1.50667505
38MP0003635_abnormal_synaptic_transmissio1.48783357
39MP0001346_abnormal_lacrimal_gland1.47214598
40MP0003329_amyloid_beta_deposits1.47086288
41MP0002282_abnormal_trachea_morphology1.44794881
42* MP0000049_abnormal_middle_ear1.40160990
43MP0009250_abnormal_appendicular_skeleto1.38545966
44MP0009384_cardiac_valve_regurgitation1.34058011
45MP0002254_reproductive_system_inflammat1.32531551
46* MP0000026_abnormal_inner_ear1.31055660
47MP0003690_abnormal_glial_cell1.26622651
48MP0000462_abnormal_digestive_system1.24478150
49MP0005248_abnormal_Harderian_gland1.23952125
50MP0000467_abnormal_esophagus_morphology1.23325920
51MP0000955_abnormal_spinal_cord1.22316113
52MP0005365_abnormal_bile_salt1.21326093
53MP0005076_abnormal_cell_differentiation1.19935251
54* MP0009780_abnormal_chondrocyte_physiolo1.19063317
55MP0009672_abnormal_birth_weight1.16823902
56MP0001188_hyperpigmentation1.16124061
57* MP0000163_abnormal_cartilage_morphology1.15928696
58MP0001216_abnormal_epidermal_layer1.14976848
59MP0002234_abnormal_pharynx_morphology1.13169545
60MP0005275_abnormal_skin_tensile1.12199993
61MP0002063_abnormal_learning/memory/cond1.09385523
62MP0001485_abnormal_pinna_reflex1.09052860
63MP0002064_seizures1.07632630
64MP0000383_abnormal_hair_follicle1.05725908
65MP0005085_abnormal_gallbladder_physiolo1.03387772
66* MP0002089_abnormal_postnatal_growth/wei1.02591757
67MP0002751_abnormal_autonomic_nervous1.02102384
68MP0003634_abnormal_glial_cell1.01870507
69MP0002233_abnormal_nose_morphology1.01322781
70MP0010771_integument_phenotype1.00485857
71MP0001984_abnormal_olfaction0.98828523
72MP0000534_abnormal_ureter_morphology0.98279962
73MP0001293_anophthalmia0.98246297
74MP0009745_abnormal_behavioral_response0.98072552
75MP0010678_abnormal_skin_adnexa0.97994738
76MP0002734_abnormal_mechanical_nocicepti0.97794618
77MP0005332_abnormal_amino_acid0.97636956
78MP0004270_analgesia0.95580691
79MP0009053_abnormal_anal_canal0.92521714
80MP0003632_abnormal_nervous_system0.92098028
81MP0003119_abnormal_digestive_system0.91933926
82MP0003861_abnormal_nervous_system0.91901285
83MP0004043_abnormal_pH_regulation0.91759937
84* MP0000428_abnormal_craniofacial_morphol0.91533744
85MP0003942_abnormal_urinary_system0.91165793
86MP0002092_abnormal_eye_morphology0.87830112
87MP0008961_abnormal_basal_metabolism0.87729863
88MP0002697_abnormal_eye_size0.85693710
89MP0003937_abnormal_limbs/digits/tail_de0.84181821
90MP0000678_abnormal_parathyroid_gland0.82424074
91MP0002572_abnormal_emotion/affect_behav0.82230817
92MP0002796_impaired_skin_barrier0.81761682
93MP0008875_abnormal_xenobiotic_pharmacok0.79848506
94MP0003879_abnormal_hair_cell0.79339785
95MP0005220_abnormal_exocrine_pancreas0.78809158
96MP0000920_abnormal_myelination0.77559463
97* MP0003755_abnormal_palate_morphology0.77448188
98MP0004782_abnormal_surfactant_physiolog0.77175444
99* MP0002882_abnormal_neuron_morphology0.76708693
100MP0001440_abnormal_grooming_behavior0.76472178
101MP0004133_heterotaxia0.75007632
102* MP0001963_abnormal_hearing_physiology0.74989226
103MP0003315_abnormal_perineum_morphology0.74957621
104MP0010329_abnormal_lipoprotein_level0.74294029
105MP0003385_abnormal_body_wall0.74011638
106MP0001340_abnormal_eyelid_morphology0.72767811
107MP0004233_abnormal_muscle_weight0.72691477
108MP0004742_abnormal_vestibular_system0.72689936
109* MP0001299_abnormal_eye_distance/0.72409460
110MP0001849_ear_inflammation0.72251495
111* MP0002111_abnormal_tail_morphology0.71789176
112MP0001286_abnormal_eye_development0.70822407
113* MP0002115_abnormal_skeleton_extremities0.70722122
114MP0009046_muscle_twitch0.70714418
115MP0000377_abnormal_hair_follicle0.69786607
116* MP0003115_abnormal_respiratory_system0.68525683
117MP0003453_abnormal_keratinocyte_physiol0.67976322
118MP0004019_abnormal_vitamin_homeostasis0.67694933
119MP0003631_nervous_system_phenotype0.67619358
120MP0000639_abnormal_adrenal_gland0.67388349
121MP0005623_abnormal_meninges_morphology0.67103026
122MP0004185_abnormal_adipocyte_glucose0.66738145
123MP0002152_abnormal_brain_morphology0.66731454
124MP0001270_distended_abdomen0.66142704
125MP0003890_abnormal_embryonic-extraembry0.66087974
126MP0002557_abnormal_social/conspecific_i0.65141027
127MP0002653_abnormal_ependyma_morphology0.63994809
128MP0003075_altered_response_to0.63506741
129MP0001177_atelectasis0.62851832
130MP0003137_abnormal_impulse_conducting0.62126382
131MP0001502_abnormal_circadian_rhythm0.62060018
132MP0000604_amyloidosis0.60845962
133MP0002067_abnormal_sensory_capabilities0.60806747
134MP0003252_abnormal_bile_duct0.60773411
135MP0002932_abnormal_joint_morphology0.58953000
136MP0003633_abnormal_nervous_system0.58157751
137MP0004883_abnormal_blood_vessel0.57325494
138* MP0002116_abnormal_craniofacial_bone0.57127425
139MP0010234_abnormal_vibrissa_follicle0.56833692
140MP0002822_catalepsy0.55125529
141MP0002272_abnormal_nervous_system0.54486670
142* MP0008569_lethality_at_weaning0.54277993

Predicted human phenotypes

RankGene SetZ-score
1Adactyly (HP:0009776)5.77323191
2Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.86563335
3Aplasia cutis congenita (HP:0001057)4.47213579
4Epiphyseal dysplasia (HP:0002656)4.12543260
5Synostosis involving the elbow (HP:0003938)4.09677778
6Humeroradial synostosis (HP:0003041)4.09677778
7* Aplasia involving bones of the extremities (HP:0009825)3.90383923
8* Aplasia involving bones of the upper limbs (HP:0009823)3.90383923
9* Aplasia of the phalanges of the hand (HP:0009802)3.90383923
10Abnormality of the right ventricle (HP:0001707)3.79156547
11Arterial tortuosity (HP:0005116)3.63982297
12* Neonatal short-limb short stature (HP:0008921)3.62723094
13Skull defect (HP:0001362)3.39199580
14* Mixed hearing impairment (HP:0000410)3.21068990
15Neurofibrillary tangles (HP:0002185)3.18672080
16Split foot (HP:0001839)3.13294812
17Vascular tortuosity (HP:0004948)3.12730605
18Esophageal varix (HP:0002040)3.12477869
19Bronchomalacia (HP:0002780)3.06515159
20Hypoplastic ischia (HP:0003175)2.95592597
21Prolonged partial thromboplastin time (HP:0003645)2.95129101
22Absent toe (HP:0010760)2.90815696
23Abnormality of the pubic bones (HP:0003172)2.83931569
24* Osteoarthritis (HP:0002758)2.83275197
25Abnormal vertebral ossification (HP:0100569)2.78771668
26Hypotrichosis (HP:0001006)2.77619322
27Joint hemorrhage (HP:0005261)2.71960354
28* Megalencephaly (HP:0001355)2.69808834
29Abnormality of the ischium (HP:0003174)2.63182133
30Absent hand (HP:0004050)2.62932795
31Exostoses (HP:0100777)2.62821394
32Broad alveolar ridges (HP:0000187)2.61672084
33Complement deficiency (HP:0004431)2.57907895
34Vitreoretinal degeneration (HP:0000655)2.57593754
35Ulnar bowing (HP:0003031)2.56014355
36Choanal stenosis (HP:0000452)2.53202606
37Hypercholesterolemia (HP:0003124)2.48788387
38Hypobetalipoproteinemia (HP:0003563)2.46850234
39* Bifid scrotum (HP:0000048)2.45382915
40Delayed CNS myelination (HP:0002188)2.45033307
41Cerebral inclusion bodies (HP:0100314)2.41960211
42Palmoplantar hyperkeratosis (HP:0000972)2.40913265
43Hemorrhage of the eye (HP:0011885)2.39758321
44Alopecia of scalp (HP:0002293)2.39194243
45* Abnormality of the salivary glands (HP:0010286)2.37996864
46Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.36168152
47Oligodactyly (HP:0012165)2.35492279
48Abnormality of the distal phalanx of the thumb (HP:0009617)2.34648652
49Obstructive sleep apnea (HP:0002870)2.31913426
50Right ventricular cardiomyopathy (HP:0011663)2.31425826
51Supernumerary ribs (HP:0005815)2.28365623
52* Alacrima (HP:0000522)2.27306172
53Palmar hyperkeratosis (HP:0010765)2.25332351
54Irregular epiphyses (HP:0010582)2.23733673
55Absent eyelashes (HP:0000561)2.22815208
56* Abnormality of the middle phalanges of the toes (HP:0010183)2.21468945
57Cutaneous finger syndactyly (HP:0010554)2.21009341
58Focal motor seizures (HP:0011153)2.20688387
59Hemiplegia (HP:0002301)2.20187557
60Overriding aorta (HP:0002623)2.19583129
61Turricephaly (HP:0000262)2.18288068
62Myokymia (HP:0002411)2.15389948
63Shallow orbits (HP:0000586)2.14634898
64* Abnormality of the lacrimal duct (HP:0011481)2.12587011
65Bile duct proliferation (HP:0001408)2.12325760
66Abnormal biliary tract physiology (HP:0012439)2.12325760
67Cutaneous syndactyly (HP:0012725)2.12084551
68Spondylolisthesis (HP:0003302)2.11780345
69Woolly hair (HP:0002224)2.11683928
70Protrusio acetabuli (HP:0003179)2.10923212
71Hepatoblastoma (HP:0002884)2.10819653
72Plantar hyperkeratosis (HP:0007556)2.08986777
73Abnormal ossification of hand bones (HP:0005921)2.08979512
74Abnormality of the intervertebral disk (HP:0005108)2.08833823
75Advanced eruption of teeth (HP:0006288)2.08299753
76Oligodactyly (hands) (HP:0001180)2.05754566
77Abnormality of aromatic amino acid family metabolism (HP:0004338)2.02109296
78Abnormality of serine family amino acid metabolism (HP:0010894)2.01783500
79Abnormality of glycine metabolism (HP:0010895)2.01783500
80Hypoplastic labia majora (HP:0000059)2.00451286
81Flat acetabular roof (HP:0003180)2.00219945
82Abnormality of secondary sexual hair (HP:0009888)1.99821331
83Abnormality of the axillary hair (HP:0100134)1.99821331
84Abnormality of monocarboxylic acid metabolism (HP:0010996)1.99614491
85Tracheomalacia (HP:0002779)1.99323953
86* Coronal craniosynostosis (HP:0004440)1.98702760
87Bilateral microphthalmos (HP:0007633)1.98662503
88* Abnormality of permanent molar morphology (HP:0011071)1.98003991
89* Abnormality of the dental root (HP:0006486)1.98003991
90* Taurodontia (HP:0000679)1.98003991
91Broad face (HP:0000283)1.97832383
92Increased number of teeth (HP:0011069)1.97436390
93Abnormal hair laboratory examination (HP:0003328)1.96059116
94Broad palm (HP:0001169)1.95622652
95Pili torti (HP:0003777)1.95313255
96Esophageal atresia (HP:0002032)1.94093130
97Small epiphyses (HP:0010585)1.93963341
98Hypoplastic nipples (HP:0002557)1.93803288
99Spastic diplegia (HP:0001264)1.92319823
100Onycholysis (HP:0001806)1.91918634
101* Nasolacrimal duct obstruction (HP:0000579)1.91245997
102Abnormality of the nasal septum (HP:0000419)1.91166696
103* Partial duplication of thumb phalanx (HP:0009944)1.89716352
104Supernumerary bones of the axial skeleton (HP:0009144)1.89691323
105Ankle clonus (HP:0011448)1.89670586
106Aplasia/Hypoplasia of the fibula (HP:0006492)1.89645464
107Concave nail (HP:0001598)1.88201433
108Fragile nails (HP:0001808)1.87932369
109Septate vagina (HP:0001153)1.87157987
110Broad distal phalanx of finger (HP:0009836)1.86865290
111Hyperlipoproteinemia (HP:0010980)1.86630668
112Skin pits (HP:0100276)1.86240944
113Trigonocephaly (HP:0000243)1.85863641
114Deep venous thrombosis (HP:0002625)1.85614210
115Abnormality of complement system (HP:0005339)1.85042629
116Abnormality of the phalanges of the 2nd finger (HP:0009541)1.84486002
117Hypoplastic pelvis (HP:0008839)1.83706938
118Cavernous hemangioma (HP:0001048)1.82822295
119Genetic anticipation (HP:0003743)1.82777135
120Renal duplication (HP:0000075)1.82770962
121Abnormality of carpal bone ossification (HP:0006257)1.82415335
122Abnormality of the parietal bone (HP:0002696)1.81961800
123Hyperacusis (HP:0010780)1.81060729
124Acanthocytosis (HP:0001927)1.80181734
125Abnormal hand bone ossification (HP:0010660)1.79772728
126Abnormality of nail color (HP:0100643)1.79252668
127Protuberant abdomen (HP:0001538)1.79231803
128Scanning speech (HP:0002168)1.78770182
129Long nose (HP:0003189)1.78634645
130Porencephaly (HP:0002132)1.78589750
131Progressive cerebellar ataxia (HP:0002073)1.78492092
132Pseudobulbar signs (HP:0002200)1.77818461
133Erythroderma (HP:0001019)1.77696098
134Bowel incontinence (HP:0002607)1.77454637
135Delayed epiphyseal ossification (HP:0002663)1.76587009
136* Abnormality of the dental pulp (HP:0006479)1.75737924
137Asymmetry of the thorax (HP:0001555)1.75606991
138Aortic aneurysm (HP:0004942)1.75531425
139* Abnormality of molar morphology (HP:0011070)1.74884684
140* Abnormality of molar (HP:0011077)1.74884684
14111 pairs of ribs (HP:0000878)1.74844362
142Neoplasm of the heart (HP:0100544)1.74757323
143Anophthalmia (HP:0000528)1.74657095
144Xanthomatosis (HP:0000991)1.74474681
145* Corneal erosion (HP:0200020)1.74176044
146Laryngomalacia (HP:0001601)1.74123311
147Insomnia (HP:0100785)1.73769201
148Abnormality of the labia majora (HP:0012881)1.73485079
149Oligodontia (HP:0000677)1.72525953
150Midline defect of the nose (HP:0004122)1.72494432
151Dysdiadochokinesis (HP:0002075)1.71309176
152Short hallux (HP:0010109)1.70118166
153Glomerulonephritis (HP:0000099)1.69990933
154Congenital ichthyosiform erythroderma (HP:0007431)1.69923137
155Action tremor (HP:0002345)1.69354558
156Epileptic encephalopathy (HP:0200134)1.69349879
157Ankyloglossia (HP:0010296)1.68359062
158Down-sloping shoulders (HP:0200021)1.68121555
159Bicuspid aortic valve (HP:0001647)1.68102551
160Potter facies (HP:0002009)1.67359542
161Facial shape deformation (HP:0011334)1.67359542
162Hemiparesis (HP:0001269)1.65523189
163Hypoplastic toenails (HP:0001800)1.65478593
164Coxa vara (HP:0002812)1.65274187
165Hypoalphalipoproteinemia (HP:0003233)1.65126701
166Abnormality of the proximal phalanges of the hand (HP:0009834)1.64885426
167Fibular aplasia (HP:0002990)1.64671693
168Flat capital femoral epiphysis (HP:0003370)1.64631960
169Aplasia/Hypoplasia of the clavicles (HP:0006710)1.63803346
170Anomalous pulmonary venous return (HP:0010772)1.63363746
171Striae distensae (HP:0001065)1.63067022
172* Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.62507512
173Status epilepticus (HP:0002133)1.61497724
174Portal hypertension (HP:0001409)1.60410316
175* Abnormality of the antihelix (HP:0009738)1.60287542
176Fibular hypoplasia (HP:0003038)1.60063735
177Hyperglycinuria (HP:0003108)1.59365407
178Back pain (HP:0003418)1.58944860
179Hydroxyprolinuria (HP:0003080)1.58769067
180Abnormality of proline metabolism (HP:0010907)1.58769067

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB18.40495049
2DDR23.38508503
3EPHA43.37351656
4EEF2K2.97806334
5CDK82.84099723
6ICK2.61881893
7EPHA22.61378526
8SIK12.31550747
9MAP3K72.16710612
10NTRK22.14071916
11LMTK22.11679702
12EPHB22.09163517
13NTRK31.95986014
14MAPK151.93745277
15TNIK1.89854991
16CDK121.88187318
17PHKG21.84620146
18PHKG11.84620146
19TRIB31.77438813
20PRKD31.67820174
21UHMK11.58773884
22SMG11.58773870
23PRKCZ1.52316573
24MUSK1.49566894
25PNCK1.47994171
26RIPK11.47438617
27MST1R1.45022246
28ROCK21.44726837
29BCKDK1.42208188
30WNK41.41724210
31FGFR21.41213192
32PAK61.40638540
33ROCK11.39280539
34MARK21.32704331
35DAPK21.31177671
36MAPKAPK31.30567808
37KSR11.28404473
38MAP3K41.24373134
39LATS11.21600243
40MINK11.17561702
41SGK4941.17335101
42SGK2231.17335101
43CAMKK11.16092622
44CDK91.09898432
45MELK1.07589582
46NTRK11.04262951
47WNK11.04010085
48MARK11.01757320
49MAP3K91.01033014
50NEK60.98007741
51ERBB20.96136119
52PRPF4B0.92237628
53* FGFR30.89876575
54MET0.88606621
55MAP2K40.88427678
56STK380.87841429
57BMX0.87045892
58MAP3K60.85923023
59DYRK1B0.85443243
60CDK50.82642359
61MTOR0.82361346
62RET0.81698312
63TYRO30.78447122
64KSR20.75205143
65DMPK0.75025558
66MAP2K70.73232648
67SGK10.72226485
68MAPK100.71353306
69RPS6KB10.71156490
70SIK20.70214003
71CASK0.70151453
72MAPK130.69913197
73MAPK120.68491762
74BRSK10.67775969
75LATS20.67767829
76PKN20.67750215
77RPS6KB20.67238967
78AKT20.65656641
79SGK20.64817842
80PAK30.64687287
81PRKCG0.63653382
82DYRK1A0.63563269
83PTK20.63410852
84PTK2B0.62138551
85PDPK10.60724091
86MAPK90.59901774
87PTK60.58309916
88PRKG20.58306655
89STK390.57623462
90MAPKAPK50.55986705
91CSNK1E0.55877898
92PRKAA20.54668986
93MAP2K60.53558838
94OXSR10.53452371
95CAMK1D0.53194489
96PDGFRA0.52850467
97SGK30.52328056
98CDK150.52058130
99CDK180.51782339
100NEK20.51771429
101BCR0.51487054
102PAK40.51289162
103CDK30.51024011
104TAOK10.50583762
105RPS6KA20.49458050
106CDK190.48574938
107RPS6KA30.47419489
108CAMK1G0.45586588
109AKT30.44925508
110CDC42BPA0.44365649
111STK240.44104984
112WEE10.43744231
113ERBB40.43572236
114IRAK30.41060924
115CDK70.40470772
116GSK3B0.39701496
117PRKACG0.39472105
118NME10.39438553
119CDK11A0.39403333
120MAP2K20.39266399
121* FGFR10.38415866
122BRD40.38371093
123INSRR0.38271651
124PRKCA0.38106977
125CDK140.38007848
126PRKCH0.37787741
127MAP3K130.37073518
128CAMK2B0.36717965
129TLK10.36697025
130SRC0.36564118
131MAP3K20.35220550
132MAP3K100.33085291
133FER0.32962609
134FYN0.32903835
135ERN10.32632029
136PRKCB0.31085642
137CAMK2A0.30941959
138FGFR40.30582637
139STK110.30103683
140STK38L0.30042146
141TTK0.29593884
142PINK10.25848516

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009105.46258435
2Dorso-ventral axis formation_Homo sapiens_hsa043202.88908116
3Basal cell carcinoma_Homo sapiens_hsa052172.69442033
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.58346659
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.45807404
6Notch signaling pathway_Homo sapiens_hsa043302.45228474
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.30916818
8Fatty acid biosynthesis_Homo sapiens_hsa000612.22226950
9Hedgehog signaling pathway_Homo sapiens_hsa043402.17300608
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.05271477
11Arginine biosynthesis_Homo sapiens_hsa002201.87162820
12Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.77724439
13Bile secretion_Homo sapiens_hsa049761.69435848
14Fatty acid metabolism_Homo sapiens_hsa012121.65592496
15Fat digestion and absorption_Homo sapiens_hsa049751.61117946
16Fatty acid degradation_Homo sapiens_hsa000711.59474997
17Nicotine addiction_Homo sapiens_hsa050331.49718572
18Prion diseases_Homo sapiens_hsa050201.46369250
19Salivary secretion_Homo sapiens_hsa049701.40019285
20PPAR signaling pathway_Homo sapiens_hsa033201.35003280
21GABAergic synapse_Homo sapiens_hsa047271.33327978
22Glutamatergic synapse_Homo sapiens_hsa047241.30223052
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.28092986
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.26164110
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.25551561
26Olfactory transduction_Homo sapiens_hsa047401.23871654
27Circadian entrainment_Homo sapiens_hsa047131.22967475
28Melanogenesis_Homo sapiens_hsa049161.22503389
29Vitamin B6 metabolism_Homo sapiens_hsa007501.22034242
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.20617320
31Butanoate metabolism_Homo sapiens_hsa006501.17779215
32Hippo signaling pathway_Homo sapiens_hsa043901.14446090
33Gastric acid secretion_Homo sapiens_hsa049711.13462175
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.10944392
35Tryptophan metabolism_Homo sapiens_hsa003801.07156318
36Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.06569076
37Complement and coagulation cascades_Homo sapiens_hsa046101.01529193
38Steroid biosynthesis_Homo sapiens_hsa001001.00616455
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97815037
40Insulin secretion_Homo sapiens_hsa049110.94670298
41Axon guidance_Homo sapiens_hsa043600.94480473
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92801421
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92312327
44Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90900427
45beta-Alanine metabolism_Homo sapiens_hsa004100.90502773
46Protein digestion and absorption_Homo sapiens_hsa049740.90344149
47ErbB signaling pathway_Homo sapiens_hsa040120.89444913
48Glioma_Homo sapiens_hsa052140.87805053
49Estrogen signaling pathway_Homo sapiens_hsa049150.87324024
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87279610
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86752654
52Tyrosine metabolism_Homo sapiens_hsa003500.86697218
53Choline metabolism in cancer_Homo sapiens_hsa052310.83999717
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83885533
55VEGF signaling pathway_Homo sapiens_hsa043700.83377817
56Gap junction_Homo sapiens_hsa045400.83105190
57Propanoate metabolism_Homo sapiens_hsa006400.83061190
58Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.82261827
59Cocaine addiction_Homo sapiens_hsa050300.81839437
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81589118
61* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.78529266
62Wnt signaling pathway_Homo sapiens_hsa043100.78163423
63Renin secretion_Homo sapiens_hsa049240.77546030
64Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.76657756
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76351393
66Peroxisome_Homo sapiens_hsa041460.76237625
67Morphine addiction_Homo sapiens_hsa050320.75823871
68Tight junction_Homo sapiens_hsa045300.75268692
69ECM-receptor interaction_Homo sapiens_hsa045120.74833593
70Lysine degradation_Homo sapiens_hsa003100.74685850
71Calcium signaling pathway_Homo sapiens_hsa040200.73522351
72Sphingolipid metabolism_Homo sapiens_hsa006000.71541279
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70475734
74cAMP signaling pathway_Homo sapiens_hsa040240.70266699
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70052793
76Insulin signaling pathway_Homo sapiens_hsa049100.69740089
77Adherens junction_Homo sapiens_hsa045200.68636968
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68438892
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68098300
80Amphetamine addiction_Homo sapiens_hsa050310.66820430
81Pancreatic secretion_Homo sapiens_hsa049720.66477307
82Proteoglycans in cancer_Homo sapiens_hsa052050.66135435
83Long-term potentiation_Homo sapiens_hsa047200.66110639
84Arginine and proline metabolism_Homo sapiens_hsa003300.63802085
85Long-term depression_Homo sapiens_hsa047300.63316478
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62640850
87Inositol phosphate metabolism_Homo sapiens_hsa005620.61868408
88AMPK signaling pathway_Homo sapiens_hsa041520.60680907
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59323733
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57714920
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.57210286
92Linoleic acid metabolism_Homo sapiens_hsa005910.56557614
93Dopaminergic synapse_Homo sapiens_hsa047280.55116274
94Chemical carcinogenesis_Homo sapiens_hsa052040.54119033
95Fatty acid elongation_Homo sapiens_hsa000620.54020123
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53797125
97Retinol metabolism_Homo sapiens_hsa008300.53547238
98Histidine metabolism_Homo sapiens_hsa003400.53298996
99Synaptic vesicle cycle_Homo sapiens_hsa047210.52947591
100Starch and sucrose metabolism_Homo sapiens_hsa005000.52733382
101Endometrial cancer_Homo sapiens_hsa052130.51491841
102Oxytocin signaling pathway_Homo sapiens_hsa049210.51034584
103Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49554978
104Dilated cardiomyopathy_Homo sapiens_hsa054140.48300379
105Cholinergic synapse_Homo sapiens_hsa047250.48153681
106Steroid hormone biosynthesis_Homo sapiens_hsa001400.47307063
1072-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46519366
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.46237451
109* Central carbon metabolism in cancer_Homo sapiens_hsa052300.46193244
110Taste transduction_Homo sapiens_hsa047420.46147201
111Thyroid hormone synthesis_Homo sapiens_hsa049180.45937319
112Ether lipid metabolism_Homo sapiens_hsa005650.43935319
113Phenylalanine metabolism_Homo sapiens_hsa003600.43008525
114ABC transporters_Homo sapiens_hsa020100.42995347
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42766154
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.42399320
117Glucagon signaling pathway_Homo sapiens_hsa049220.42218246
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.41000510
119GnRH signaling pathway_Homo sapiens_hsa049120.40693794
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40576862
121Biosynthesis of amino acids_Homo sapiens_hsa012300.39827077
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.37821959
123Vitamin digestion and absorption_Homo sapiens_hsa049770.37687243
124Mineral absorption_Homo sapiens_hsa049780.37052874
125Focal adhesion_Homo sapiens_hsa045100.36138939
126Glycerolipid metabolism_Homo sapiens_hsa005610.36031674

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