FGFR4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.54968336
2L-phenylalanine catabolic process (GO:0006559)7.54968336
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.28555461
4L-phenylalanine metabolic process (GO:0006558)7.28555461
5aromatic amino acid family catabolic process (GO:0009074)6.82703249
6tryptophan catabolic process (GO:0006569)6.23781999
7indole-containing compound catabolic process (GO:0042436)6.23781999
8indolalkylamine catabolic process (GO:0046218)6.23781999
9kynurenine metabolic process (GO:0070189)6.05324748
10glyoxylate metabolic process (GO:0046487)6.03672999
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.00166350
12tryptophan metabolic process (GO:0006568)5.86816971
13bile acid biosynthetic process (GO:0006699)5.81688369
14cysteine metabolic process (GO:0006534)5.75010751
15proline metabolic process (GO:0006560)5.58448346
16protein-lipid complex assembly (GO:0065005)5.51993971
17negative regulation of fibrinolysis (GO:0051918)5.51812092
18urea cycle (GO:0000050)5.51574167
19urea metabolic process (GO:0019627)5.51574167
20serine family amino acid catabolic process (GO:0009071)5.46711865
21sulfur amino acid catabolic process (GO:0000098)5.43741131
22intestinal cholesterol absorption (GO:0030299)5.40155667
23alpha-linolenic acid metabolic process (GO:0036109)5.35639141
24high-density lipoprotein particle remodeling (GO:0034375)5.31901276
25protein carboxylation (GO:0018214)5.28063319
26peptidyl-glutamic acid carboxylation (GO:0017187)5.28063319
27regulation of fibrinolysis (GO:0051917)5.27360349
28regulation of protein activation cascade (GO:2000257)5.23500264
29complement activation, alternative pathway (GO:0006957)5.15932872
30nitrogen cycle metabolic process (GO:0071941)5.07294900
31homocysteine metabolic process (GO:0050667)5.00606104
32lysine metabolic process (GO:0006553)5.00256416
33lysine catabolic process (GO:0006554)5.00256416
34aromatic amino acid family metabolic process (GO:0009072)4.99574140
35bile acid metabolic process (GO:0008206)4.96956336
36regulation of complement activation (GO:0030449)4.89828995
37fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.89408965
38plasma lipoprotein particle organization (GO:0071827)4.78201920
39proline biosynthetic process (GO:0006561)4.75784834
40amino-acid betaine metabolic process (GO:0006577)4.72722176
41alpha-amino acid catabolic process (GO:1901606)4.68962909
42tyrosine metabolic process (GO:0006570)4.67376425
43reverse cholesterol transport (GO:0043691)4.65528036
44glycine metabolic process (GO:0006544)4.62537112
45acylglycerol homeostasis (GO:0055090)4.57735097
46triglyceride homeostasis (GO:0070328)4.57735097
47regulation of triglyceride catabolic process (GO:0010896)4.57099270
48regulation of cholesterol biosynthetic process (GO:0045540)4.56637175
49regulation of cholesterol esterification (GO:0010872)4.55120446
50protein-lipid complex remodeling (GO:0034368)4.50322866
51macromolecular complex remodeling (GO:0034367)4.50322866
52plasma lipoprotein particle remodeling (GO:0034369)4.50322866
53negative regulation of sterol transport (GO:0032372)4.49909232
54negative regulation of cholesterol transport (GO:0032375)4.49909232
55protein-lipid complex subunit organization (GO:0071825)4.49887857
56serine family amino acid metabolic process (GO:0009069)4.49564003
57regulation of plasminogen activation (GO:0010755)4.41517111
58cellular ketone body metabolic process (GO:0046950)4.39366575
59indolalkylamine metabolic process (GO:0006586)4.37827601
60glutamate metabolic process (GO:0006536)4.36546593
61cellular amino acid catabolic process (GO:0009063)4.33750727
62bile acid and bile salt transport (GO:0015721)4.32570367
63regulation of apoptotic cell clearance (GO:2000425)4.27616339
64cellular biogenic amine catabolic process (GO:0042402)4.26934937
65amine catabolic process (GO:0009310)4.26934937
66serine family amino acid biosynthetic process (GO:0009070)4.25892087
67phospholipid efflux (GO:0033700)4.24611845
68imidazole-containing compound metabolic process (GO:0052803)4.23377169
69coenzyme catabolic process (GO:0009109)4.21978414
70drug catabolic process (GO:0042737)4.20465160
71cellular modified amino acid catabolic process (GO:0042219)4.20426171
72plasma lipoprotein particle clearance (GO:0034381)4.18791489
73benzene-containing compound metabolic process (GO:0042537)4.17302120
74cellular glucuronidation (GO:0052695)4.14997803
75intestinal absorption (GO:0050892)4.05502855
76ethanol oxidation (GO:0006069)4.05015377
77urate metabolic process (GO:0046415)4.04618333
78fibrinolysis (GO:0042730)3.97761952
79arginine metabolic process (GO:0006525)3.95205586
80cholesterol efflux (GO:0033344)3.94877059
81dicarboxylic acid biosynthetic process (GO:0043650)3.94793451
82aldehyde catabolic process (GO:0046185)3.92663961
83regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.89266320
84drug transmembrane transport (GO:0006855)3.86004646
85ketone body metabolic process (GO:1902224)3.78577416
86plasma lipoprotein particle assembly (GO:0034377)3.78244288
87organic acid catabolic process (GO:0016054)3.76948542
88carboxylic acid catabolic process (GO:0046395)3.76948542
89short-chain fatty acid metabolic process (GO:0046459)3.76640576
90cholesterol homeostasis (GO:0042632)3.70983200
91glucuronate metabolic process (GO:0019585)3.70737611
92uronic acid metabolic process (GO:0006063)3.70737611
93acetyl-CoA metabolic process (GO:0006084)3.69820871
94positive regulation of triglyceride lipase activity (GO:0061365)3.69160356
95positive regulation of lipoprotein lipase activity (GO:0051006)3.69160356
96exogenous drug catabolic process (GO:0042738)3.68019637
97sterol homeostasis (GO:0055092)3.66401825
98phospholipid homeostasis (GO:0055091)3.64867419
99complement activation, classical pathway (GO:0006958)3.64094246
100low-density lipoprotein particle remodeling (GO:0034374)3.63200330
101aspartate family amino acid catabolic process (GO:0009068)3.62468442
102blood coagulation, intrinsic pathway (GO:0007597)3.59511648
103cofactor catabolic process (GO:0051187)3.56955949
104complement activation (GO:0006956)3.56067795
105positive regulation of lipid catabolic process (GO:0050996)3.55442455
106very-low-density lipoprotein particle assembly (GO:0034379)3.55297080
1072-oxoglutarate metabolic process (GO:0006103)3.53299025
108regulation of cholesterol metabolic process (GO:0090181)3.52398877
109protein activation cascade (GO:0072376)3.52124283
110lipoprotein metabolic process (GO:0042157)3.52056194
111cytolysis (GO:0019835)3.51570528
112negative regulation of lipase activity (GO:0060192)3.50908042
113positive regulation of steroid metabolic process (GO:0045940)3.48669155
114glutamine family amino acid biosynthetic process (GO:0009084)3.46715521
115* regulation of cholesterol homeostasis (GO:2000188)3.46598876
116positive regulation of hormone metabolic process (GO:0032352)3.40328714
117positive regulation of fatty acid biosynthetic process (GO:0045723)3.39764839
118renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.39655183
119L-serine metabolic process (GO:0006563)3.36910900
120L-alpha-amino acid transmembrane transport (GO:1902475)3.30695213
121embryonic retina morphogenesis in camera-type eye (GO:0060059)3.29149996
1224-hydroxyproline metabolic process (GO:0019471)3.25761896
123diacylglycerol metabolic process (GO:0046339)3.25649564
124negative regulation of blood coagulation (GO:0030195)3.20246111
125negative regulation of hemostasis (GO:1900047)3.20246111
126sterol transport (GO:0015918)3.17265709
127cholesterol transport (GO:0030301)3.17265709
128regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.15705718
129acute-phase response (GO:0006953)3.11416793
130epoxygenase P450 pathway (GO:0019373)3.07430843
131lipid homeostasis (GO:0055088)3.00919729
132positive regulation of hormone biosynthetic process (GO:0046886)2.97073886
133negative regulation of coagulation (GO:0050819)2.96329264
134ethanol metabolic process (GO:0006067)2.95275049
135negative regulation of protein activation cascade (GO:2000258)2.87390134
136regulation of lipoprotein particle clearance (GO:0010984)2.82883761
137negative regulation of wound healing (GO:0061045)2.81720559
138positive regulation of hemostasis (GO:1900048)2.81559228
139positive regulation of blood coagulation (GO:0030194)2.81559228
140positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.81421096
141negative regulation of lipid transport (GO:0032369)2.78796354
142cellular zinc ion homeostasis (GO:0006882)2.77743791
143* regulation of bile acid biosynthetic process (GO:0070857)2.74208352
144vitamin transmembrane transport (GO:0035461)2.73078842
145regulation of fatty acid biosynthetic process (GO:0042304)2.72887860
146basement membrane organization (GO:0071711)2.72301390
147low-density lipoprotein particle clearance (GO:0034383)2.70147007
148glutamine family amino acid catabolic process (GO:0009065)2.68222328
149fatty acid homeostasis (GO:0055089)2.66887097

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.30377744
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.21191150
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.57148227
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.41837776
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.09734087
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.89821241
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.87365065
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.08386218
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.78569659
10E2F7_22180533_ChIP-Seq_HELA_Human2.21331268
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.18721926
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.15346953
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.11042104
14TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.07127652
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.7935659
16CLOCK_20551151_ChIP-Seq_293T_Human1.99170253
17ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.83535439
18EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70270039
19FOXA2_19822575_ChIP-Seq_HepG2_Human1.63204100
20MYC_18555785_ChIP-Seq_MESCs_Mouse1.56615631
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.53108761
22ZFP281_18757296_ChIP-ChIP_E14_Mouse1.50603609
23* HNF4A_19822575_ChIP-Seq_HepG2_Human1.46156208
24HIF1A_21447827_ChIP-Seq_MCF-7_Human1.44751277
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.42786968
26CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.41442146
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.40902518
28PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.39459214
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.38932745
30* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38656343
31TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33715697
32GATA1_22025678_ChIP-Seq_K562_Human1.33677290
33TET1_21451524_ChIP-Seq_MESCs_Mouse1.33273516
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.32715532
35NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.31079703
36DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.30042299
37* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29108199
38STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25423521
39ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24970463
40MYC_18358816_ChIP-ChIP_MESCs_Mouse1.24430104
41ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23198303
42HTT_18923047_ChIP-ChIP_STHdh_Human1.22737633
43POU5F1_16518401_ChIP-PET_MESCs_Mouse1.22303336
44ZNF263_19887448_ChIP-Seq_K562_Human1.21743890
45SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21417502
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21396522
47SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.20873575
48DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.20360961
49CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20359920
50P68_20966046_ChIP-Seq_HELA_Human1.19936884
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.19675826
52KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19117892
53MYC_19079543_ChIP-ChIP_MESCs_Mouse1.18888317
54MYC_22102868_ChIP-Seq_BL_Human1.17862177
55* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.16962760
56* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16282961
57SOX2_27498859_Chip-Seq_STOMACH_Mouse1.16070676
58ELK3_25401928_ChIP-Seq_HUVEC_Human1.13224306
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.11531348
60MYC_19030024_ChIP-ChIP_MESCs_Mouse1.11332956
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.10010212
62SMC4_20622854_ChIP-Seq_HELA_Human1.09890380
63MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.07320837
64RUNX1_27514584_Chip-Seq_MCF-7_Human1.07319750
65KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06708364
66UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06658202
67ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06106619
68* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05103213
69NELFA_20434984_ChIP-Seq_ESCs_Mouse1.04509486
70GATA4_25053715_ChIP-Seq_YYC3_Human1.01220195
71NANOG_21062744_ChIP-ChIP_HESCs_Human1.01059466
72KDM2B_26808549_Chip-Seq_K562_Human1.00988236
73FOXM1_23109430_ChIP-Seq_U2OS_Human1.00305941
74SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99962257
75TCF3_18692474_ChIP-Seq_MEFs_Mouse0.98948173
76TP53_22127205_ChIP-Seq_IMR90_Human0.98130502
77XRN2_22483619_ChIP-Seq_HELA_Human0.97451718
78ESR1_21235772_ChIP-Seq_MCF-7_Human0.96862380
79WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95435352
80CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95173650
81* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94129451
82STAT3_1855785_ChIP-Seq_MESCs_Mouse0.91577026
83PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.90600229
84* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.90086870
85ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.89463808
86NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.88958448
87SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.83779902
88CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.82864921
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.80456624
90SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.79420585
91AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78167470
92PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.77387007
93RARA_24833708_ChIP-Seq_LIVER_Mouse0.75986228
94RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.75949306
95LXR_22292898_ChIP-Seq_THP-1_Human0.73243403
96AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.71259208
97KAP1_22055183_ChIP-Seq_ESCs_Mouse0.70447060
98GATA6_25053715_ChIP-Seq_YYC3_Human0.69820632
99FOXO3_23340844_ChIP-Seq_DLD1_Human0.67691237
100RARB_24833708_ChIP-Seq_LIVER_Mouse0.66038676
101NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.64968758
102PPAR_26484153_Chip-Seq_NCI-H1993_Human0.63035429
103BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.62924016
104* IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.62484171
105RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61513628
106* CDX2_20551321_ChIP-Seq_CACO-2_Human0.59972113
107RACK7_27058665_Chip-Seq_MCF-7_Human0.59000561
108TRIM28_21343339_ChIP-Seq_HEK293_Human0.58980661
109BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.58077086
110CEBPB_22108803_ChIP-Seq_LS180_Human0.57543731
111FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.56923986
112AR_21909140_ChIP-Seq_LNCAP_Human0.56821331
113Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.55929973
114FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.55500311
115* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.55416359
116E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.55023648
117NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.53752225
118NRF2_20460467_ChIP-Seq_MEFs_Mouse0.53752225
119PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.52227755
120FOXA1_25552417_ChIP-Seq_VCAP_Human0.51853616
121FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.51612495
122ERG_21242973_ChIP-ChIP_JURKAT_Human0.51435012
123MYC_19915707_ChIP-ChIP_AK7_Human0.51210108
124EGR1_19032775_ChIP-ChIP_M12_Human0.50819441
125POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.49852396
126PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.49138244
127PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.48198716
128STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.46169909
129ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.46123299
130ESR1_20079471_ChIP-ChIP_T-47D_Human0.46068698
131TP63_17297297_ChIP-ChIP_HaCaT_Human0.45751380
132IRF8_22096565_ChIP-ChIP_GC-B_Human0.44878285
133ESET_19884257_ChIP-Seq_ESCs_Mouse0.44489988
134GATA1_19941826_ChIP-Seq_K562_Human0.44172001
135SOX2_20726797_ChIP-Seq_SW620_Human0.43943074
136GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.43394926
137AR_20517297_ChIP-Seq_VCAP_Human0.42983594
138CBP_21632823_ChIP-Seq_H3396_Human0.42847198
139* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42599086
140GATA3_24758297_ChIP-Seq_MCF-7_Human0.42197600
141CREB1_26743006_Chip-Seq_LNCaP_Human0.41738996
142SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.41554503
143ATF3_27146783_Chip-Seq_COLON_Human0.41483401
144TAF2_19829295_ChIP-Seq_ESCs_Human0.41378531
145P53_21459846_ChIP-Seq_SAOS-2_Human0.40738047
146SOX2_18692474_ChIP-Seq_MEFs_Mouse0.40329058
147KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.39693433
148STAT1_17558387_ChIP-Seq_HELA_Human0.39674024
149ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.39260060
150MYC_27129775_Chip-Seq_CORNEA_Mouse0.38828345

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.25976955
2MP0005360_urolithiasis7.72315443
3MP0005085_abnormal_gallbladder_physiolo6.16428239
4MP0005365_abnormal_bile_salt5.96260500
5MP0008875_abnormal_xenobiotic_pharmacok4.92820897
6MP0003806_abnormal_nucleotide_metabolis4.06407186
7MP0000566_synostosis4.03474639
8MP0003252_abnormal_bile_duct3.95170058
9MP0003122_maternal_imprinting3.63414323
10MP0010329_abnormal_lipoprotein_level3.41983871
11MP0009840_abnormal_foam_cell3.26829293
12MP0005332_abnormal_amino_acid2.97279542
13MP0005083_abnormal_biliary_tract2.95018504
14MP0003195_calcinosis2.88245892
15MP0003123_paternal_imprinting2.62508754
16MP0001666_abnormal_nutrient_absorption2.59774056
17MP0002138_abnormal_hepatobiliary_system2.46794088
18MP0002089_abnormal_postnatal_growth/wei2.43734417
19MP0004019_abnormal_vitamin_homeostasis2.40056011
20MP0003191_abnormal_cellular_cholesterol2.32154433
21MP0000609_abnormal_liver_physiology2.08968797
22MP0002118_abnormal_lipid_homeostasis2.00442554
23MP0005319_abnormal_enzyme/_coenzyme1.82959558
24MP0003868_abnormal_feces_composition1.73107403
25MP0009780_abnormal_chondrocyte_physiolo1.72335681
26MP0003941_abnormal_skin_development1.65038309
27MP0004272_abnormal_basement_membrane1.59883556
28MP0003705_abnormal_hypodermis_morpholog1.59467770
29MP0001764_abnormal_homeostasis1.52536621
30MP0009643_abnormal_urine_homeostasis1.49928568
31MP0005451_abnormal_body_composition1.49310054
32MP0005584_abnormal_enzyme/coenzyme_acti1.48655976
33MP0005076_abnormal_cell_differentiation1.47533671
34MP0005257_abnormal_intraocular_pressure1.42098370
35MP0002249_abnormal_larynx_morphology1.30317384
36MP0003115_abnormal_respiratory_system1.29778634
37MP0010030_abnormal_orbit_morphology1.27476214
38MP0009697_abnormal_copulation1.23101496
39MP0003186_abnormal_redox_activity1.22528364
40MP0003011_delayed_dark_adaptation1.19281611
41MP0003121_genomic_imprinting1.17061159
42MP0000598_abnormal_liver_morphology1.17044561
43MP0001915_intracranial_hemorrhage1.16754398
44MP0003942_abnormal_urinary_system1.16595881
45MP0001849_ear_inflammation1.13447471
46MP0000678_abnormal_parathyroid_gland1.11599979
47MP0005636_abnormal_mineral_homeostasis1.08876758
48MP0010368_abnormal_lymphatic_system1.08622434
49MP0001730_embryonic_growth_arrest1.07830863
50MP0003656_abnormal_erythrocyte_physiolo1.07219682
51MP0003567_abnormal_fetal_cardiomyocyte1.06391591
52MP0003172_abnormal_lysosome_physiology1.05871980
53MP0002697_abnormal_eye_size1.02525530
54MP0003693_abnormal_embryo_hatching1.02316837
55MP0005084_abnormal_gallbladder_morpholo0.99845996
56MP0005647_abnormal_sex_gland0.99425224
57MP0004858_abnormal_nervous_system0.97551008
58MP0005377_hearing/vestibular/ear_phenot0.96943644
59MP0003878_abnormal_ear_physiology0.96943644
60MP0001346_abnormal_lacrimal_gland0.93703282
61MP0002938_white_spotting0.93623603
62MP0009764_decreased_sensitivity_to0.92612213
63MP0003315_abnormal_perineum_morphology0.92427727
64MP0004957_abnormal_blastocyst_morpholog0.91766459
65MP0000003_abnormal_adipose_tissue0.91419995
66MP0009763_increased_sensitivity_to0.90988853
67MP0003566_abnormal_cell_adhesion0.90934970
68MP0003119_abnormal_digestive_system0.90875067
69MP0004233_abnormal_muscle_weight0.90367781
70MP0004185_abnormal_adipocyte_glucose0.89979994
71MP0003890_abnormal_embryonic-extraembry0.89526051
72MP0000537_abnormal_urethra_morphology0.88275228
73MP0000604_amyloidosis0.88234445
74MP0001756_abnormal_urination0.88020110
75MP0005409_darkened_coat_color0.87607306
76MP0005220_abnormal_exocrine_pancreas0.87266397
77MP0002254_reproductive_system_inflammat0.86644271
78MP0009642_abnormal_blood_homeostasis0.83926216
79MP0002086_abnormal_extraembryonic_tissu0.81202252
80MP0008469_abnormal_protein_level0.80131795
81MP0005408_hypopigmentation0.79602420
82MP0009053_abnormal_anal_canal0.79115073
83MP0006036_abnormal_mitochondrial_physio0.76096312
84MP0004133_heterotaxia0.75562898
85MP0003943_abnormal_hepatobiliary_system0.75442184
86MP0001672_abnormal_embryogenesis/_devel0.73973451
87MP0005380_embryogenesis_phenotype0.73973451
88MP0002909_abnormal_adrenal_gland0.73924818
89MP0005376_homeostasis/metabolism_phenot0.73285002
90MP0001661_extended_life_span0.72537745
91MP0003111_abnormal_nucleus_morphology0.72446781
92MP0003984_embryonic_growth_retardation0.71840698
93MP0002078_abnormal_glucose_homeostasis0.70141050
94MP0002092_abnormal_eye_morphology0.69477385
95MP0002136_abnormal_kidney_physiology0.69205382
96MP0002088_abnormal_embryonic_growth/wei0.69186149
97MP0000462_abnormal_digestive_system0.69142425
98MP0001286_abnormal_eye_development0.68393816
99MP0002971_abnormal_brown_adipose0.68203031
100MP0001697_abnormal_embryo_size0.67907455
101MP0005670_abnormal_white_adipose0.67819143
102MP0002928_abnormal_bile_duct0.67213464
103MP0004270_analgesia0.65763437
104MP0009765_abnormal_xenobiotic_induced0.65667216
105MP0002876_abnormal_thyroid_physiology0.65291163
106MP0003937_abnormal_limbs/digits/tail_de0.62296226
107MP0005379_endocrine/exocrine_gland_phen0.61750560
108MP0000477_abnormal_intestine_morphology0.61677558
109MP0002233_abnormal_nose_morphology0.61562356
110MP0010630_abnormal_cardiac_muscle0.61277339
111MP0002098_abnormal_vibrissa_morphology0.61133797
112MP0002080_prenatal_lethality0.60678985
113MP0005334_abnormal_fat_pad0.60358280
114MP0009703_decreased_birth_body0.60266420
115MP0004197_abnormal_fetal_growth/weight/0.59890746
116MP0005395_other_phenotype0.59888993
117MP0005266_abnormal_metabolism0.57406010
118MP0004130_abnormal_muscle_cell0.54228950
119MP0003718_maternal_effect0.53636552
120MP0000639_abnormal_adrenal_gland0.52234194
121MP0005535_abnormal_body_temperature0.52147920
122MP0003329_amyloid_beta_deposits0.51599732
123MP0002796_impaired_skin_barrier0.48886649
124MP0009384_cardiac_valve_regurgitation0.48542464
125MP0004264_abnormal_extraembryonic_tissu0.48312208
126MP0003638_abnormal_response/metabolism_0.48256054
127MP0006035_abnormal_mitochondrial_morpho0.48118717
128MP0009672_abnormal_birth_weight0.47423806
129MP0004043_abnormal_pH_regulation0.47163124
130MP0005448_abnormal_energy_balance0.45244887
131MP0002168_other_aberrant_phenotype0.45207461
132MP0004782_abnormal_surfactant_physiolog0.43570586
133MP0010234_abnormal_vibrissa_follicle0.42499282
134MP0003690_abnormal_glial_cell0.42235221
135MP0001765_abnormal_ion_homeostasis0.40709158
136MP0005666_abnormal_adipose_tissue0.40052405
137MP0002060_abnormal_skin_morphology0.39658017
138MP0000579_abnormal_nail_morphology0.38572089
139MP0001243_abnormal_dermal_layer0.38193523
140MP0003953_abnormal_hormone_level0.37436466
141MP0008873_increased_physiological_sensi0.36294174
142MP0002135_abnormal_kidney_morphology0.36005315
143MP0005248_abnormal_Harderian_gland0.35841034
144MP0000230_abnormal_systemic_arterial0.33994518
145MP0002269_muscular_atrophy0.33654889
146MP0003075_altered_response_to0.32300680
147MP0005166_decreased_susceptibility_to0.32253768
148MP0003300_gastrointestinal_ulcer0.31743135
149MP0003724_increased_susceptibility_to0.31526740
150MP0009115_abnormal_fat_cell0.31465670
151MP0005058_abnormal_lysosome_morphology0.30253820
152MP0005464_abnormal_platelet_physiology0.28703166
153MP0008874_decreased_physiological_sensi0.28294474
154MP0005023_abnormal_wound_healing0.27551594
155MP0004883_abnormal_blood_vessel0.27459878
156MP0000249_abnormal_blood_vessel0.27301641
157MP0003453_abnormal_keratinocyte_physiol0.26944282
158MP0002970_abnormal_white_adipose0.26749224
159MP0008872_abnormal_physiological_respon0.25841569
160MP0000538_abnormal_urinary_bladder0.25619764

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.23397142
2Deep venous thrombosis (HP:0002625)7.22937587
3Intrahepatic cholestasis (HP:0001406)7.04753423
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.52006001
5Xanthomatosis (HP:0000991)6.19173783
6Prolonged partial thromboplastin time (HP:0003645)6.04297326
7Hypobetalipoproteinemia (HP:0003563)5.98021901
8Hyperlipoproteinemia (HP:0010980)5.22171332
9Complement deficiency (HP:0004431)5.14173221
10Hyperglycinemia (HP:0002154)4.79029484
11Hyperammonemia (HP:0001987)4.59891451
12Hypolipoproteinemia (HP:0010981)4.58787063
13Abnormality of glutamine family amino acid metabolism (HP:0010902)4.53975260
14Hyperglycinuria (HP:0003108)4.47688266
15Joint hemorrhage (HP:0005261)4.45452138
16Abnormality of glycine metabolism (HP:0010895)4.31358669
17Abnormality of serine family amino acid metabolism (HP:0010894)4.31358669
18Ketosis (HP:0001946)4.26354496
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.25618148
20Abnormality of the common coagulation pathway (HP:0010990)4.22390200
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.13515648
22Hypoalphalipoproteinemia (HP:0003233)4.12226355
23Abnormality of aspartate family amino acid metabolism (HP:0010899)4.07320889
24Epidermoid cyst (HP:0200040)4.06982044
25Fat malabsorption (HP:0002630)3.99830434
26Abnormality of methionine metabolism (HP:0010901)3.92088379
27Abnormality of complement system (HP:0005339)3.87203511
28Hypoglycemic coma (HP:0001325)3.77551994
29Abnormality of pyrimidine metabolism (HP:0004353)3.69409533
30Abnormality of the intrinsic pathway (HP:0010989)3.56943422
31Gout (HP:0001997)3.52869988
32Asymmetry of the thorax (HP:0001555)3.48640573
33Conjugated hyperbilirubinemia (HP:0002908)3.46631907
34Abnormality of fatty-acid metabolism (HP:0004359)3.39342525
35Hypercholesterolemia (HP:0003124)3.33771566
36Abnormality of nucleobase metabolism (HP:0010932)3.29161139
37Delayed CNS myelination (HP:0002188)3.17980689
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.17704336
39Ketoacidosis (HP:0001993)3.12622886
40Abnormality of serum amino acid levels (HP:0003112)3.11536583
41Hyperbilirubinemia (HP:0002904)3.09669833
42Abnormality of purine metabolism (HP:0004352)3.09036942
43Myocardial infarction (HP:0001658)3.07317559
44Hepatocellular carcinoma (HP:0001402)3.06703295
45Steatorrhea (HP:0002570)3.00147318
46Spontaneous abortion (HP:0005268)2.85576208
47Vaginal fistula (HP:0004320)2.77238134
48Metabolic acidosis (HP:0001942)2.77138877
49Vascular calcification (HP:0004934)2.76353143
50Flat acetabular roof (HP:0003180)2.73773748
51Hypochromic microcytic anemia (HP:0004840)2.68242287
52Hepatoblastoma (HP:0002884)2.67754116
53Abnormality of dicarboxylic acid metabolism (HP:0010995)2.64704739
54Dicarboxylic aciduria (HP:0003215)2.64704739
55Lethargy (HP:0001254)2.63386140
56Malnutrition (HP:0004395)2.62812438
57Abnormality of carpal bone ossification (HP:0006257)2.62669693
58Bronchomalacia (HP:0002780)2.57794777
59Systemic lupus erythematosus (HP:0002725)2.56303157
60Skin nodule (HP:0200036)2.54845828
61Spastic diplegia (HP:0001264)2.52529903
62Cardiovascular calcification (HP:0011915)2.49468776
63Pterygium (HP:0001059)2.48027147
64Mitral stenosis (HP:0001718)2.46028355
65Neonatal onset (HP:0003623)2.44499852
66Abnormal tarsal ossification (HP:0008369)2.43203746
67Broad alveolar ridges (HP:0000187)2.42907301
68Esophageal varix (HP:0002040)2.42682103
69Irritability (HP:0000737)2.38602609
70Enlarged kidneys (HP:0000105)2.33175374
71Late onset (HP:0003584)2.32936814
72Hypoglycemic seizures (HP:0002173)2.30885331
73Hyperuricemia (HP:0002149)2.28557583
74Increased purine levels (HP:0004368)2.28557583
75Glomerulonephritis (HP:0000099)2.27933067
76Hydroxyprolinuria (HP:0003080)2.25870176
77Abnormality of proline metabolism (HP:0010907)2.25870176
78Bifid scrotum (HP:0000048)2.24603712
79Abnormal gallbladder morphology (HP:0012437)2.22924464
80Popliteal pterygium (HP:0009756)2.21681390
81Generalized aminoaciduria (HP:0002909)2.21011981
82Cholelithiasis (HP:0001081)2.20473052
83Proximal tubulopathy (HP:0000114)2.19698616
84Alkalosis (HP:0001948)2.16787927
85Choanal stenosis (HP:0000452)2.16775032
86Small epiphyses (HP:0010585)2.16423937
87Sensorimotor neuropathy (HP:0007141)2.15701967
88Cerebral edema (HP:0002181)2.14269042
89Rickets (HP:0002748)2.14228394
90Acanthocytosis (HP:0001927)2.13665327
91Osteomalacia (HP:0002749)2.12321980
92Pancreatitis (HP:0001733)2.10230052
93Vomiting (HP:0002013)2.09971533
94Pancreatic islet-cell hyperplasia (HP:0004510)2.08919632
95Amyloidosis (HP:0011034)2.08474624
96Hemorrhage of the eye (HP:0011885)2.08230831
97Thrombophlebitis (HP:0004418)2.03717795
98Abnormal cartilage morphology (HP:0002763)2.03145170
99Abnormal enzyme/coenzyme activity (HP:0012379)2.01001441
100Recurrent gram-negative bacterial infections (HP:0005420)1.99868696
101Abnormal gallbladder physiology (HP:0012438)1.99265503
102Cholecystitis (HP:0001082)1.99265503
103Brushfield spots (HP:0001088)1.98143242
104Abnormal ossification of hand bones (HP:0005921)1.97360677
105Hypophosphatemic rickets (HP:0004912)1.94950380
106Widely patent fontanelles and sutures (HP:0004492)1.93613623
107Malignant hyperthermia (HP:0002047)1.93314278
108Menorrhagia (HP:0000132)1.92527593
109Abnormality of urine glucose concentration (HP:0011016)1.91375239
110Glycosuria (HP:0003076)1.91375239
111Gingival bleeding (HP:0000225)1.89931397
112Broad palm (HP:0001169)1.89604681
113Opisthotonus (HP:0002179)1.89356750
114Abnormality of glycolysis (HP:0004366)1.87893724
115Hyperglycemia (HP:0003074)1.86990217
116Abnormality of transition element cation homeostasis (HP:0011030)1.86520919
117Abnormality of the nasal septum (HP:0000419)1.86074252
118Hypoplasia of the capital femoral epiphysis (HP:0003090)1.85202455
119Abnormality of the gallbladder (HP:0005264)1.85123789
120Hyperinsulinemic hypoglycemia (HP:0000825)1.84923638
121Alacrima (HP:0000522)1.84752704
122Potter facies (HP:0002009)1.84076298
123Facial shape deformation (HP:0011334)1.84076298
124Abnormality of iron homeostasis (HP:0011031)1.83411246
125Abnormal hand bone ossification (HP:0010660)1.82950613
126Lymphangioma (HP:0100764)1.82446608
127Neonatal death (HP:0003811)1.81009443
128Abnormality of the Achilles tendon (HP:0005109)1.79625560
129Impaired pain sensation (HP:0007328)1.79299503
130Abnormality of pain sensation (HP:0010832)1.79299503
131Abnormal delivery (HP:0001787)1.78608191
132Increased serum pyruvate (HP:0003542)1.78136101
133Partial duplication of thumb phalanx (HP:0009944)1.77946189
134Abnormality of the lacrimal duct (HP:0011481)1.76095683
135Renal duplication (HP:0000075)1.73760352
136Abnormality of the lumbar spine (HP:0100712)1.70689469
137Ulnar bowing (HP:0003031)1.70034026
138Abnormality of the vitreous humor (HP:0004327)1.67087512
139Pigmentary retinal degeneration (HP:0001146)1.66979588
140Wide cranial sutures (HP:0010537)1.65896901
141Diastasis recti (HP:0001540)1.65242973
142Septate vagina (HP:0001153)1.63499698
143Nephroblastoma (Wilms tumor) (HP:0002667)1.61379683
144Renovascular hypertension (HP:0100817)1.61074343
145Overlapping toe (HP:0001845)1.58290526
146Back pain (HP:0003418)1.56821879
147Biconcave vertebral bodies (HP:0004586)1.56200652
148Akinesia (HP:0002304)1.55375015
149Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.55059670

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.03154089
2ERN14.57770066
3SIK14.42275649
4SMG13.22746162
5EEF2K3.09942662
6ERBB42.85193147
7TRIB32.69063296
8CDK122.60454044
9TAOK32.57299117
10MST1R2.53481539
11PKN22.32049402
12LATS12.29220740
13INSRR2.26124887
14TYRO31.96557914
15PTK61.89649761
16MAPK111.80840425
17STK38L1.69665534
18MAP2K41.68510417
19EPHA21.62741458
20PIK3CG1.57570061
21EPHB11.55476047
22CDK71.52963771
23LMTK21.50443546
24FLT31.46539148
25NEK91.44615838
26ABL21.41142638
27RIPK11.35968485
28TYK21.32550682
29EPHA31.29551059
30* FGFR41.25641390
31MAP3K31.24925681
32MAP3K101.24581189
33MAP3K71.24561603
34RPS6KB21.24527252
35FRK1.21661948
36MAP2K31.20242039
37KDR1.19179452
38FGFR21.18775025
39TTK1.17467584
40MET1.16038299
41PBK1.15393659
42MAPK151.14093354
43ERBB21.11067077
44MUSK1.08707644
45DAPK21.08448294
46NME11.08329334
47WNK41.07818156
48WNK31.07337446
49PTK21.06072640
50TIE11.04787708
51GRK61.04786979
52JAK21.04273339
53PRKAA20.99313556
54PINK10.98796062
55DYRK1B0.97935382
56CDK60.97390548
57MAPKAPK30.96344773
58PIK3CA0.95106076
59GSK3A0.91900410
60BRSK10.91156387
61PRKG20.89325447
62MAP3K110.87022437
63PRKCI0.85457746
64TGFBR20.84801131
65PRKCZ0.84609952
66MTOR0.80635965
67STK390.78420197
68TBK10.77973121
69JAK10.77104880
70NEK20.75221478
71MATK0.75088470
72MAPK40.73640984
73RET0.72270355
74PRKAA10.71550461
75MAP2K60.69930091
76CDK40.69700767
77DDR20.68601905
78BRD40.66376683
79MAP2K20.66312351
80LATS20.64400735
81CSNK1E0.64042479
82CAMK2G0.63880879
83BRSK20.63423523
84PRKACG0.63006705
85TSSK60.62408705
86SGK30.61873194
87MAP2K10.61514741
88CSK0.60480570
89FGFR30.59602048
90PDK30.58577583
91PDK40.58577583
92MAPK120.58078234
93AKT30.57633732
94FER0.57038824
95NME20.56790647
96BMX0.56471984
97CDK80.54882105
98NEK10.53670060
99EPHB20.52360031
100TAOK20.51971446
101MAP3K90.51950574
102OXSR10.51829460
103PDPK10.51108699
104ICK0.50652003
105RPS6KB10.49066793
106IRAK30.48118251
107PDGFRA0.48085013
108CDC42BPA0.47563098
109STK30.47269419
110OBSCN0.45867962
111MAP3K140.45789935
112CDK10.45133012
113CAMK1D0.43189049
114PASK0.43118529
115ALK0.42633978
116CSNK1G10.42218394
117BUB10.41179409
118RPS6KA10.40661791
119PDK20.40162387
120SGK4940.39794302
121SGK2230.39794302
122MAP3K20.39027131
123CHEK10.38568235
124MAP3K80.37975249
125CDK150.37809961
126DAPK10.37710321
127FGFR10.37349013
128CDC70.37188202
129CDK20.36142829
130SGK20.35492213
131CHEK20.35389490
132VRK20.35314520
133CDK11A0.35022380
134GRK10.34371748
135SRPK10.33593201
136MAPK70.33391914
137CDK180.32927072
138PLK10.32051604
139AKT20.31333627
140RPS6KA20.30978301
141CSNK2A20.29072295
142CHUK0.28940773
143NTRK10.28371679
144EIF2AK10.28186844
145IGF1R0.28161645
146CSNK2A10.27742794
147GSK3B0.27718081
148MAP3K50.26663647
149MAPK140.26485341
150SCYL20.26395616
151MAP3K10.25396797
152CSNK1D0.25114988
153AURKB0.24599484
154PAK40.24505235
155STK380.24268938
156EGFR0.23741557
157PAK30.23695240
158CDK90.22539543

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.33822616
2Nitrogen metabolism_Homo sapiens_hsa009103.48699935
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.41338412
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.27451960
5Arginine biosynthesis_Homo sapiens_hsa002202.99432114
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.81420153
7Tryptophan metabolism_Homo sapiens_hsa003802.70292851
8Complement and coagulation cascades_Homo sapiens_hsa046102.65716724
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.65149640
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.53526025
11Fatty acid degradation_Homo sapiens_hsa000712.50499747
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.44378724
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.32361955
14Butanoate metabolism_Homo sapiens_hsa006502.23995340
15Peroxisome_Homo sapiens_hsa041462.07448672
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.05177390
17Propanoate metabolism_Homo sapiens_hsa006401.94790006
18Histidine metabolism_Homo sapiens_hsa003401.88938415
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.86455356
20Chemical carcinogenesis_Homo sapiens_hsa052041.84684343
21PPAR signaling pathway_Homo sapiens_hsa033201.83934511
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.83031750
23Fatty acid metabolism_Homo sapiens_hsa012121.78618658
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.76693728
25beta-Alanine metabolism_Homo sapiens_hsa004101.73024498
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.70816323
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.68387816
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.66154488
29Selenocompound metabolism_Homo sapiens_hsa004501.65912337
30Retinol metabolism_Homo sapiens_hsa008301.65609332
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.64477535
32Staphylococcus aureus infection_Homo sapiens_hsa051501.58451775
33Bile secretion_Homo sapiens_hsa049761.55696969
34Caffeine metabolism_Homo sapiens_hsa002321.53350369
35Other glycan degradation_Homo sapiens_hsa005111.49904138
36Phenylalanine metabolism_Homo sapiens_hsa003601.49118484
37Pyruvate metabolism_Homo sapiens_hsa006201.41195619
38Tyrosine metabolism_Homo sapiens_hsa003501.37393543
39Sulfur metabolism_Homo sapiens_hsa009201.37111625
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36443751
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.32305006
42Folate biosynthesis_Homo sapiens_hsa007901.32005165
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.27288438
44Starch and sucrose metabolism_Homo sapiens_hsa005001.26084823
45Biosynthesis of amino acids_Homo sapiens_hsa012301.25328123
46Carbon metabolism_Homo sapiens_hsa012001.20210199
47Fat digestion and absorption_Homo sapiens_hsa049751.19550052
48Fatty acid elongation_Homo sapiens_hsa000621.18976863
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.14799486
50Vitamin B6 metabolism_Homo sapiens_hsa007501.14086716
51Steroid biosynthesis_Homo sapiens_hsa001001.13764339
52ABC transporters_Homo sapiens_hsa020101.11431326
53Vitamin digestion and absorption_Homo sapiens_hsa049771.07278727
54Arginine and proline metabolism_Homo sapiens_hsa003301.05962378
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03863332
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03605659
57Sulfur relay system_Homo sapiens_hsa041220.97308231
58N-Glycan biosynthesis_Homo sapiens_hsa005100.94598182
59Lysine degradation_Homo sapiens_hsa003100.90847913
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89209575
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79651501
62One carbon pool by folate_Homo sapiens_hsa006700.78624642
63Glutathione metabolism_Homo sapiens_hsa004800.77094479
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74010553
65Glycerolipid metabolism_Homo sapiens_hsa005610.73289801
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68684528
67Pentose phosphate pathway_Homo sapiens_hsa000300.63659350
68Sphingolipid metabolism_Homo sapiens_hsa006000.60066917
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59787778
70Metabolic pathways_Homo sapiens_hsa011000.46408687
71Tight junction_Homo sapiens_hsa045300.46145349
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43934500
73Fatty acid biosynthesis_Homo sapiens_hsa000610.40634582
74Thyroid cancer_Homo sapiens_hsa052160.39586336
75Prion diseases_Homo sapiens_hsa050200.36639889
76* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33141903
77Fructose and mannose metabolism_Homo sapiens_hsa000510.31136520
78ECM-receptor interaction_Homo sapiens_hsa045120.29497107
79Adherens junction_Homo sapiens_hsa045200.29244283
80Galactose metabolism_Homo sapiens_hsa000520.27898919
81Insulin resistance_Homo sapiens_hsa049310.25598778
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24650148
83Basal cell carcinoma_Homo sapiens_hsa052170.23559352
84mRNA surveillance pathway_Homo sapiens_hsa030150.21983376
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.21962184
86Hippo signaling pathway_Homo sapiens_hsa043900.21699342
87Base excision repair_Homo sapiens_hsa034100.19975350
88DNA replication_Homo sapiens_hsa030300.18693426
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.17285096
90Linoleic acid metabolism_Homo sapiens_hsa005910.17167265
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15272146
92Glucagon signaling pathway_Homo sapiens_hsa049220.07014966
93AMPK signaling pathway_Homo sapiens_hsa041520.04455734
94Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2016321
95Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1963355
96Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1799494
97Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1792632
98Mineral absorption_Homo sapiens_hsa04978-0.1707694
99Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1601117
100Hepatitis C_Homo sapiens_hsa05160-0.1450407
101Amoebiasis_Homo sapiens_hsa05146-0.1385068
102Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1355256
103Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1332448
104Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1286546
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1279454
106Bladder cancer_Homo sapiens_hsa05219-0.1155799
107Insulin signaling pathway_Homo sapiens_hsa04910-0.1087680
108Regulation of autophagy_Homo sapiens_hsa04140-0.1056508
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0972791
110Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0906906
111Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0683418
112Renin-angiotensin system_Homo sapiens_hsa04614-0.0471680
113Protein digestion and absorption_Homo sapiens_hsa04974-0.0177696
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0156290

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