FGG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.51460739
2L-phenylalanine catabolic process (GO:0006559)7.51460739
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.18581016
4L-phenylalanine metabolic process (GO:0006558)7.18581016
5aromatic amino acid family catabolic process (GO:0009074)6.74792878
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.44628890
7exogenous drug catabolic process (GO:0042738)6.43940558
8epoxygenase P450 pathway (GO:0019373)6.23936789
9indole-containing compound catabolic process (GO:0042436)6.12063144
10indolalkylamine catabolic process (GO:0046218)6.12063144
11tryptophan catabolic process (GO:0006569)6.12063144
12kynurenine metabolic process (GO:0070189)6.01028097
13negative regulation of fibrinolysis (GO:0051918)5.89804229
14bile acid biosynthetic process (GO:0006699)5.89578246
15omega-hydroxylase P450 pathway (GO:0097267)5.86417110
16glyoxylate metabolic process (GO:0046487)5.82889855
17* positive regulation of heterotypic cell-cell adhesion (GO:0034116)5.80657703
18tryptophan metabolic process (GO:0006568)5.75748125
19regulation of protein activation cascade (GO:2000257)5.70666365
20urea cycle (GO:0000050)5.69857790
21urea metabolic process (GO:0019627)5.69857790
22high-density lipoprotein particle remodeling (GO:0034375)5.68967643
23regulation of fibrinolysis (GO:0051917)5.68371820
24complement activation, alternative pathway (GO:0006957)5.59348452
25alpha-linolenic acid metabolic process (GO:0036109)5.54060226
26protein carboxylation (GO:0018214)5.50345469
27peptidyl-glutamic acid carboxylation (GO:0017187)5.50345469
28cysteine metabolic process (GO:0006534)5.30713408
29regulation of complement activation (GO:0030449)5.26041386
30sulfur amino acid catabolic process (GO:0000098)5.25886157
31nitrogen cycle metabolic process (GO:0071941)5.23116977
32intestinal cholesterol absorption (GO:0030299)5.20809617
33serine family amino acid catabolic process (GO:0009071)5.05866022
34reverse cholesterol transport (GO:0043691)5.03263931
35bile acid metabolic process (GO:0008206)5.03113611
36regulation of plasminogen activation (GO:0010755)5.02770713
37regulation of cholesterol esterification (GO:0010872)5.00019395
38regulation of triglyceride catabolic process (GO:0010896)4.94662497
39protein-lipid complex remodeling (GO:0034368)4.92661386
40macromolecular complex remodeling (GO:0034367)4.92661386
41plasma lipoprotein particle remodeling (GO:0034369)4.92661386
42fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.90207186
43aromatic amino acid family metabolic process (GO:0009072)4.90009534
44regulation of humoral immune response (GO:0002920)4.87338797
45tyrosine metabolic process (GO:0006570)4.75661882
46homocysteine metabolic process (GO:0050667)4.72105237
47phospholipid efflux (GO:0033700)4.71730938
48triglyceride homeostasis (GO:0070328)4.68216439
49acylglycerol homeostasis (GO:0055090)4.68216439
50protein-lipid complex subunit organization (GO:0071825)4.64391986
51alpha-amino acid catabolic process (GO:1901606)4.58181135
52negative regulation of hemostasis (GO:1900047)4.56864043
53negative regulation of blood coagulation (GO:0030195)4.56864043
54negative regulation of cholesterol transport (GO:0032375)4.55271507
55negative regulation of sterol transport (GO:0032372)4.55271507
56amino-acid betaine metabolic process (GO:0006577)4.54003205
57lysine catabolic process (GO:0006554)4.53173376
58lysine metabolic process (GO:0006553)4.53173376
59plasma lipoprotein particle clearance (GO:0034381)4.50366066
60drug metabolic process (GO:0017144)4.44579985
61glycine metabolic process (GO:0006544)4.36670315
62cholesterol efflux (GO:0033344)4.35843763
63cellular ketone body metabolic process (GO:0046950)4.35674712
64bile acid and bile salt transport (GO:0015721)4.33961411
65indolalkylamine metabolic process (GO:0006586)4.33063691
66coenzyme catabolic process (GO:0009109)4.31882021
67imidazole-containing compound metabolic process (GO:0052803)4.30786369
68cellular biogenic amine catabolic process (GO:0042402)4.22847944
69amine catabolic process (GO:0009310)4.22847944
70glutamate metabolic process (GO:0006536)4.21808604
71regulation of apoptotic cell clearance (GO:2000425)4.20989611
72cellular amino acid catabolic process (GO:0009063)4.20304773
73negative regulation of coagulation (GO:0050819)4.19028319
74fibrinolysis (GO:0042730)4.18730780
75plasma lipoprotein particle assembly (GO:0034377)4.15855277
76serine family amino acid metabolic process (GO:0009069)4.13257745
77cellular glucuronidation (GO:0052695)4.13169118
78negative regulation of wound healing (GO:0061045)4.11425528
79benzene-containing compound metabolic process (GO:0042537)4.08245929
80low-density lipoprotein particle remodeling (GO:0034374)4.06747691
81blood coagulation, intrinsic pathway (GO:0007597)4.05072476
82ethanol metabolic process (GO:0006067)4.04498111
83dicarboxylic acid biosynthetic process (GO:0043650)4.04469377
84cellular modified amino acid catabolic process (GO:0042219)4.02029584
85arginine metabolic process (GO:0006525)4.00573534
86serine family amino acid biosynthetic process (GO:0009070)3.99748200
87negative regulation of protein activation cascade (GO:2000258)3.96690212
88aldehyde catabolic process (GO:0046185)3.96611783
89ethanol oxidation (GO:0006069)3.96337428
90oxidative demethylation (GO:0070989)3.94878989
91complement activation, classical pathway (GO:0006958)3.92388534
92positive regulation of lipoprotein lipase activity (GO:0051006)3.92096728
93positive regulation of triglyceride lipase activity (GO:0061365)3.92096728
94protein activation cascade (GO:0072376)3.91223428
95acute-phase response (GO:0006953)3.91015391
96killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.90408670
97disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.90408670
98positive regulation of hemostasis (GO:1900048)3.89997985
99positive regulation of blood coagulation (GO:0030194)3.89997985
100complement activation (GO:0006956)3.87332893
101lipoprotein metabolic process (GO:0042157)3.84666070
102very-low-density lipoprotein particle assembly (GO:0034379)3.84247589
103phospholipid homeostasis (GO:0055091)3.82047415
104positive regulation of lipid catabolic process (GO:0050996)3.80827403
105drug catabolic process (GO:0042737)3.79928558
106cofactor catabolic process (GO:0051187)3.79818739
107cholesterol transport (GO:0030301)3.79362231
108sterol transport (GO:0015918)3.79362231
109negative regulation of lipase activity (GO:0060192)3.76943168
110ketone body metabolic process (GO:1902224)3.76909710
111cholesterol homeostasis (GO:0042632)3.76629515
112plasma lipoprotein particle organization (GO:0071827)3.75979826
113opsonization (GO:0008228)3.74975834
114cytolysis (GO:0019835)3.74522824
115negative regulation of complement activation (GO:0045916)3.73074192
116protein-lipid complex assembly (GO:0065005)3.72160503
117sterol homeostasis (GO:0055092)3.70351566
118heme transport (GO:0015886)3.68705668
119organic acid catabolic process (GO:0016054)3.66812141
120carboxylic acid catabolic process (GO:0046395)3.66812141
121regulation of cholesterol homeostasis (GO:2000188)3.66347729
122uronic acid metabolic process (GO:0006063)3.65868234
123glucuronate metabolic process (GO:0019585)3.65868234
124regulation of bile acid biosynthetic process (GO:0070857)3.65402292
125positive regulation of coagulation (GO:0050820)3.61662089
126* regulation of heterotypic cell-cell adhesion (GO:0034114)3.58498865
127acute inflammatory response (GO:0002526)3.56930425
128phenylpropanoid metabolic process (GO:0009698)3.54958457
129positive regulation of fatty acid biosynthetic process (GO:0045723)3.44976690
130flavonoid metabolic process (GO:0009812)3.39882611
131doxorubicin metabolic process (GO:0044598)3.34180770

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.34641661
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.16412498
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse7.02780103
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.48097146
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.29652212
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.26251687
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.81587762
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.12695689
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.10968967
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.05485668
11* ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.0336508
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.99590128
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92975080
14* FOXA2_19822575_ChIP-Seq_HepG2_Human1.62360382
15GATA1_22025678_ChIP-Seq_K562_Human1.56356614
16CLOCK_20551151_ChIP-Seq_293T_Human1.55398717
17HTT_18923047_ChIP-ChIP_STHdh_Human1.54722638
18* HNF4A_19822575_ChIP-Seq_HepG2_Human1.40810888
19PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.40784663
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.36514009
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25852927
22CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.23267815
23TCF4_18268006_ChIP-ChIP_LS174T_Human1.21909099
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.20104351
25RXRA_24833708_ChIP-Seq_LIVER_Mouse1.20023661
26ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18858853
27FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10220939
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00200521
29ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97271183
30TRIM28_21343339_ChIP-Seq_HEK293_Human0.96810613
31TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.94625923
32SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90994565
33IRF8_22096565_ChIP-ChIP_GC-B_Human0.90757471
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89609583
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.83043663
36PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.82948935
37RARG_19884340_ChIP-ChIP_MEFs_Mouse0.82286122
38ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.80177652
39GATA4_25053715_ChIP-Seq_YYC3_Human0.78995437
40BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78109242
41CDX2_19796622_ChIP-Seq_MESCs_Mouse0.77186640
42SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76836416
43* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.76507663
44AR_21909140_ChIP-Seq_LNCAP_Human0.74593314
45ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.74143946
46KAP1_22055183_ChIP-Seq_ESCs_Mouse0.73529909
47RARA_24833708_ChIP-Seq_LIVER_Mouse0.73393997
48SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.73261783
49ZNF263_19887448_ChIP-Seq_K562_Human0.72207588
50CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.72011981
51Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.71812398
52SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70114660
53TP53_16413492_ChIP-PET_HCT116_Human0.68125034
54AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.68044012
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.67569939
56ESR2_21235772_ChIP-Seq_MCF-7_Human0.67522290
57NFE2_27457419_Chip-Seq_LIVER_Mouse0.66861964
58PCGF2_27294783_Chip-Seq_NPCs_Mouse0.64663118
59NRF2_20460467_ChIP-Seq_MEFs_Mouse0.64113594
60NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.64113594
61SMAD1_18555785_Chip-Seq_ESCs_Mouse0.64110885
62RARB_24833708_ChIP-Seq_LIVER_Mouse0.62032444
63ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.62025080
64NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.60592812
65RAD21_21589869_ChIP-Seq_MESCs_Mouse0.59695934
66BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.58498037
67OCT4_18555785_Chip-Seq_ESCs_Mouse0.58133063
68NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.57559633
69CEBPB_22108803_ChIP-Seq_LS180_Human0.56255887
70GATA3_24758297_ChIP-Seq_MCF-7_Human0.56121083
71POU5F1_16518401_ChIP-PET_MESCs_Mouse0.56119459
72ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.55721694
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.55342755
74STAT3_1855785_ChIP-Seq_MESCs_Mouse0.54365024
75EGR1_19032775_ChIP-ChIP_M12_Human0.54027254
76CDX2_22108803_ChIP-Seq_LS180_Human0.54019608
77FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.53614030
78ESRRB_18555785_Chip-Seq_ESCs_Mouse0.53582709
79SUZ12_27294783_Chip-Seq_NPCs_Mouse0.52940344
80AR_20517297_ChIP-Seq_VCAP_Human0.52557822
81CTNNB1_20460455_ChIP-Seq_HCT116_Human0.52247585
82ZFX_18555785_Chip-Seq_ESCs_Mouse0.52187034
83FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.52163825
84NFIB_24661679_ChIP-Seq_LUNG_Mouse0.52152025
85SOX17_20123909_ChIP-Seq_XEN_Mouse0.51680052
86EZH2_27294783_Chip-Seq_NPCs_Mouse0.51596396
87LXR_22292898_ChIP-Seq_THP-1_Human0.51398936
88RUNX1_27457419_Chip-Seq_LIVER_Mouse0.50733532
89MYC_19915707_ChIP-ChIP_AK7_Human0.50676775
90* FOXA1_25552417_ChIP-Seq_VCAP_Human0.50384575
91PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.50271583
92SOX2_21211035_ChIP-Seq_LN229_Human0.49788154
93CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.48712358
94TP53_18474530_ChIP-ChIP_U2OS_Human0.48675192
95EOMES_21245162_ChIP-Seq_HESCs_Human0.48542995
96* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.48379921
97ESR1_21235772_ChIP-Seq_MCF-7_Human0.48157238
98CBP_21632823_ChIP-Seq_H3396_Human0.47227157
99SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.46595762
100ESET_19884257_ChIP-Seq_ESCs_Mouse0.46332726
101P53_21459846_ChIP-Seq_SAOS-2_Human0.45679956
102GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.45669640
103GATA1_19941826_ChIP-Seq_K562_Human0.45275370
104CDX2_20551321_ChIP-Seq_CACO-2_Human0.45081586
105KLF4_18555785_Chip-Seq_ESCs_Mouse0.44901949
106PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.44884108
107HNFA_21074721_ChIP-Seq_CACO-2_Human0.44754304
108PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.44416830
109STAT1_17558387_ChIP-Seq_HELA_Human0.44256519
110E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.44008376
111TAF15_26573619_Chip-Seq_HEK293_Human0.43193799
112FOXO3_23340844_ChIP-Seq_DLD1_Human0.43070041
113FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.42453141
114TAF2_19829295_ChIP-Seq_ESCs_Human0.42087113
115GATA1_19941827_ChIP-Seq_MEL_Mouse0.41972149
116GATA2_19941826_ChIP-Seq_K562_Human0.41527274
117PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.40868246
118ESR1_20079471_ChIP-ChIP_T-47D_Human0.40446561
119SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.39792460
120GATA6_25053715_ChIP-Seq_YYC3_Human0.39748997
121STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.39577255
122PPAR_26484153_Chip-Seq_NCI-H1993_Human0.39394522
123BCAT_22108803_ChIP-Seq_LS180_Human0.38552646
124CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.38054782
125MYC_27129775_Chip-Seq_CORNEA_Mouse0.38019788
126ERG_21242973_ChIP-ChIP_JURKAT_Human0.35736359
127IRF1_19129219_ChIP-ChIP_H3396_Human0.35404368
128SPI1_26923725_Chip-Seq_HPCs_Mouse0.34300978
129GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.34213488
130ERG_20517297_ChIP-Seq_VCAP_Human0.33611036
131SOX2_20726797_ChIP-Seq_SW620_Human0.33385419
132NCOR_22424771_ChIP-Seq_293T_Human0.33318466
133SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.33279385
134LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.33255499

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.21579493
2MP0005360_urolithiasis7.50905337
3MP0005085_abnormal_gallbladder_physiolo6.43352130
4MP0005365_abnormal_bile_salt6.15496722
5MP0008875_abnormal_xenobiotic_pharmacok4.97803490
6MP0003806_abnormal_nucleotide_metabolis4.26152297
7MP0003252_abnormal_bile_duct3.89342393
8MP0010329_abnormal_lipoprotein_level3.63438293
9MP0009840_abnormal_foam_cell3.32369501
10MP0005083_abnormal_biliary_tract3.15805814
11MP0003195_calcinosis2.85406925
12MP0005332_abnormal_amino_acid2.73325734
13MP0001666_abnormal_nutrient_absorption2.59011633
14MP0003191_abnormal_cellular_cholesterol2.57386346
15MP0000609_abnormal_liver_physiology2.19604175
16MP0004019_abnormal_vitamin_homeostasis2.12174166
17MP0002118_abnormal_lipid_homeostasis2.10266422
18MP0002138_abnormal_hepatobiliary_system2.00749877
19MP0003868_abnormal_feces_composition1.87901207
20MP0005319_abnormal_enzyme/_coenzyme1.82682287
21MP0003122_maternal_imprinting1.65924129
22MP0001764_abnormal_homeostasis1.65274349
23MP0009697_abnormal_copulation1.63400321
24MP0005584_abnormal_enzyme/coenzyme_acti1.56499154
25MP0003011_delayed_dark_adaptation1.46400115
26MP0005451_abnormal_body_composition1.35041081
27MP0003656_abnormal_erythrocyte_physiolo1.33316122
28MP0001915_intracranial_hemorrhage1.26803852
29MP0003186_abnormal_redox_activity1.23391619
30MP0009643_abnormal_urine_homeostasis1.22985828
31MP0000598_abnormal_liver_morphology1.20135115
32MP0003705_abnormal_hypodermis_morpholog1.18628467
33MP0000604_amyloidosis1.17768568
34MP0005647_abnormal_sex_gland1.13727102
35MP0002254_reproductive_system_inflammat1.12193236
36MP0005058_abnormal_lysosome_morphology1.10753873
37MP0009764_decreased_sensitivity_to1.09392369
38MP0010368_abnormal_lymphatic_system1.07191121
39MP0009763_increased_sensitivity_to1.06944165
40MP0005636_abnormal_mineral_homeostasis0.96931892
41MP0003123_paternal_imprinting0.90887709
42* MP0008469_abnormal_protein_level0.89604618
43MP0002089_abnormal_postnatal_growth/wei0.89371429
44MP0004272_abnormal_basement_membrane0.88735504
45* MP0009642_abnormal_blood_homeostasis0.87784979
46MP0005408_hypopigmentation0.83840720
47MP0000566_synostosis0.83822466
48MP0005084_abnormal_gallbladder_morpholo0.80963170
49MP0009765_abnormal_xenobiotic_induced0.80581899
50MP0005376_homeostasis/metabolism_phenot0.80130370
51MP0005670_abnormal_white_adipose0.79857969
52MP0006036_abnormal_mitochondrial_physio0.78501891
53MP0002078_abnormal_glucose_homeostasis0.77057461
54MP0005220_abnormal_exocrine_pancreas0.76601967
55MP0002971_abnormal_brown_adipose0.73086428
56MP0002876_abnormal_thyroid_physiology0.72762964
57MP0001661_extended_life_span0.70128702
58MP0001986_abnormal_taste_sensitivity0.69876767
59MP0009053_abnormal_anal_canal0.69776709
60MP0003690_abnormal_glial_cell0.69654254
61MP0005334_abnormal_fat_pad0.68041112
62MP0003879_abnormal_hair_cell0.66225712
63MP0004130_abnormal_muscle_cell0.65887139
64MP0005535_abnormal_body_temperature0.65299482
65MP0000639_abnormal_adrenal_gland0.63050885
66MP0005266_abnormal_metabolism0.62604797
67MP0003329_amyloid_beta_deposits0.61771321
68MP0002282_abnormal_trachea_morphology0.60488800
69MP0006054_spinal_hemorrhage0.58380937
70MP0001756_abnormal_urination0.58140115
71MP0003941_abnormal_skin_development0.57378868
72MP0006035_abnormal_mitochondrial_morpho0.55126577
73MP0005409_darkened_coat_color0.54906821
74MP0005448_abnormal_energy_balance0.54606962
75MP0005395_other_phenotype0.51890594
76MP0000920_abnormal_myelination0.50302927
77MP0003436_decreased_susceptibility_to0.48492521
78MP0003724_increased_susceptibility_to0.47793800
79MP0003172_abnormal_lysosome_physiology0.46955480
80MP0003632_abnormal_nervous_system0.46580578
81* MP0005464_abnormal_platelet_physiology0.46478801
82MP0002136_abnormal_kidney_physiology0.46427004
83MP0002928_abnormal_bile_duct0.46042816
84MP0003638_abnormal_response/metabolism_0.45722180
85MP0005187_abnormal_penis_morphology0.45545638
86MP0008873_increased_physiological_sensi0.45144185
87MP0003718_maternal_effect0.44875103
88MP0009780_abnormal_chondrocyte_physiolo0.44678623
89MP0002822_catalepsy0.43621654
90MP0008874_decreased_physiological_sensi0.43369892
91MP0003075_altered_response_to0.42624893
92MP0005166_decreased_susceptibility_to0.41735811
93MP0000579_abnormal_nail_morphology0.41021151
94MP0003953_abnormal_hormone_level0.39894255
95MP0009384_cardiac_valve_regurgitation0.38880984
96MP0005248_abnormal_Harderian_gland0.38775612
97MP0003567_abnormal_fetal_cardiomyocyte0.37887956
98MP0002837_dystrophic_cardiac_calcinosis0.37707664
99MP0004782_abnormal_surfactant_physiolog0.37617235
100MP0004381_abnormal_hair_follicle0.36700262
101MP0005666_abnormal_adipose_tissue0.36437164
102MP0004883_abnormal_blood_vessel0.34734895
103MP0001324_abnormal_eye_pigmentation0.34605040
104MP0002796_impaired_skin_barrier0.34489291
105MP0009672_abnormal_birth_weight0.33932417
106MP0008872_abnormal_physiological_respon0.33798923
107MP0000249_abnormal_blood_vessel0.33648606
108MP0003633_abnormal_nervous_system0.32832237
109MP0009115_abnormal_fat_cell0.32291202
110MP0001243_abnormal_dermal_layer0.31996397
111MP0001881_abnormal_mammary_gland0.31859506
112MP0006082_CNS_inflammation0.31840237
113MP0002168_other_aberrant_phenotype0.31802534
114MP0002909_abnormal_adrenal_gland0.31737491
115MP0002970_abnormal_white_adipose0.30106968
116MP0001845_abnormal_inflammatory_respons0.30065365
117MP0003315_abnormal_perineum_morphology0.29856724
118MP0000230_abnormal_systemic_arterial0.29843115
119MP0003631_nervous_system_phenotype0.29759105
120MP0005410_abnormal_fertilization0.29678968
121MP0005164_abnormal_response_to0.29373855
122MP0001853_heart_inflammation0.29078557
123* MP0002128_abnormal_blood_circulation0.28653981
124MP0002090_abnormal_vision0.28048274
125MP0003950_abnormal_plasma_membrane0.27711848
126MP0002135_abnormal_kidney_morphology0.27522063
127MP0002132_abnormal_respiratory_system0.27187226
128MP0005167_abnormal_blood-brain_barrier0.27082400
129* MP0003699_abnormal_female_reproductive0.26844310
130MP0000371_diluted_coat_color0.26681944
131MP0004264_abnormal_extraembryonic_tissu0.26644464
132MP0005023_abnormal_wound_healing0.26154703

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.57919617
2Intrahepatic cholestasis (HP:0001406)7.32347677
3Abnormality of aromatic amino acid family metabolism (HP:0004338)7.30254450
4Prolonged partial thromboplastin time (HP:0003645)6.81060499
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.65528328
6Hypobetalipoproteinemia (HP:0003563)6.45832853
7Xanthomatosis (HP:0000991)6.33178289
8Complement deficiency (HP:0004431)5.74002506
9Hyperlipoproteinemia (HP:0010980)5.58319187
10Joint hemorrhage (HP:0005261)5.00644356
11Hypolipoproteinemia (HP:0010981)4.90844113
12Hyperammonemia (HP:0001987)4.56835487
13Epidermoid cyst (HP:0200040)4.53754715
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.48290738
15* Abnormality of the common coagulation pathway (HP:0010990)4.46962886
16Hypoalphalipoproteinemia (HP:0003233)4.35178207
17Hyperglycinemia (HP:0002154)4.34611256
18Abnormality of methionine metabolism (HP:0010901)4.26414184
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.22774989
20Abnormality of complement system (HP:0005339)4.19922186
21Ketosis (HP:0001946)4.17871152
22Fat malabsorption (HP:0002630)4.15687299
23Abnormality of aspartate family amino acid metabolism (HP:0010899)4.11462264
24Abnormality of glutamine family amino acid metabolism (HP:0010902)4.09635896
25Abnormality of the intrinsic pathway (HP:0010989)3.91358241
26Hypoglycemic coma (HP:0001325)3.87642784
27Abnormality of serine family amino acid metabolism (HP:0010894)3.80915836
28Abnormality of glycine metabolism (HP:0010895)3.80915836
29Abnormality of pyrimidine metabolism (HP:0004353)3.80413152
30Hyperglycinuria (HP:0003108)3.78416401
31Conjugated hyperbilirubinemia (HP:0002908)3.72994317
32Hypercholesterolemia (HP:0003124)3.62762493
33Hyperbilirubinemia (HP:0002904)3.33912625
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.26185685
35Abnormality of fatty-acid metabolism (HP:0004359)3.23422766
36Steatorrhea (HP:0002570)3.09766313
37Hypochromic microcytic anemia (HP:0004840)3.06620622
38Myocardial infarction (HP:0001658)3.02222229
39Abnormality of serum amino acid levels (HP:0003112)3.01721548
40Hepatocellular carcinoma (HP:0001402)3.01431688
41Abnormality of nucleobase metabolism (HP:0010932)3.00340086
42Delayed CNS myelination (HP:0002188)2.98457676
43Ketoacidosis (HP:0001993)2.95433488
44Systemic lupus erythematosus (HP:0002725)2.87761654
45Skin nodule (HP:0200036)2.80054099
46Osteomalacia (HP:0002749)2.78388151
47* Spontaneous abortion (HP:0005268)2.78055597
48Acanthocytosis (HP:0001927)2.70296374
49Metabolic acidosis (HP:0001942)2.69719065
50Glomerulonephritis (HP:0000099)2.67102976
51Amyloidosis (HP:0011034)2.65717671
52Abnormality of purine metabolism (HP:0004352)2.60303553
53Vascular calcification (HP:0004934)2.57163735
54Lethargy (HP:0001254)2.55483898
55Hypoglycemic seizures (HP:0002173)2.54154931
56Recurrent gram-negative bacterial infections (HP:0005420)2.52671383
57Purpura (HP:0000979)2.51994448
58Abnormal gallbladder morphology (HP:0012437)2.47760627
59Abnormality of dicarboxylic acid metabolism (HP:0010995)2.47060696
60Dicarboxylic aciduria (HP:0003215)2.47060696
61Spastic diplegia (HP:0001264)2.45560057
62Cholelithiasis (HP:0001081)2.42668660
63Mitral stenosis (HP:0001718)2.41846796
64Cerebral edema (HP:0002181)2.38469514
65Gout (HP:0001997)2.37968328
66Abnormal gallbladder physiology (HP:0012438)2.35418735
67Cholecystitis (HP:0001082)2.35418735
68Irritability (HP:0000737)2.32231420
69Neonatal onset (HP:0003623)2.32068016
70Retinal atrophy (HP:0001105)2.28122535
71Cardiovascular calcification (HP:0011915)2.28048817
72Abnormal tarsal ossification (HP:0008369)2.26546268
73Esophageal varix (HP:0002040)2.24978699
74Menorrhagia (HP:0000132)2.24461092
75Malnutrition (HP:0004395)2.24263257
76Increased serum pyruvate (HP:0003542)2.18052653
77Sensorimotor neuropathy (HP:0007141)2.13901174
78Pancreatitis (HP:0001733)2.13302793
79Arthropathy (HP:0003040)2.12748269
80* Joint swelling (HP:0001386)2.12704700
81Poikilocytosis (HP:0004447)2.12485368
82Late onset (HP:0003584)2.11819390
83Enlarged kidneys (HP:0000105)2.10438190
84* Gingival bleeding (HP:0000225)2.09928206
85Brushfield spots (HP:0001088)2.06522271
86Hyperinsulinemic hypoglycemia (HP:0000825)2.06262014
87Abnormality of iron homeostasis (HP:0011031)2.03760500
88Vomiting (HP:0002013)2.03312061
89* Thrombophlebitis (HP:0004418)2.03008262
90Hemorrhage of the eye (HP:0011885)2.02489638
91Abnormality of carpal bone ossification (HP:0006257)2.01438987
92Abnormality of the gallbladder (HP:0005264)2.00312832
93* Abnormal delivery (HP:0001787)1.99721292
94Abnormality of transition element cation homeostasis (HP:0011030)1.99405211
95Opisthotonus (HP:0002179)1.98282725
96Generalized aminoaciduria (HP:0002909)1.94331911
97Rickets (HP:0002748)1.91301479
98Abnormality of glycolysis (HP:0004366)1.89274767
99Glycosuria (HP:0003076)1.88241634
100Abnormality of urine glucose concentration (HP:0011016)1.88241634
101Nephritis (HP:0000123)1.87538496
102Hypophosphatemic rickets (HP:0004912)1.86577944
103Abnormal cartilage morphology (HP:0002763)1.83895788
104Elevated alkaline phosphatase (HP:0003155)1.83010121
105Abnormality of the Achilles tendon (HP:0005109)1.82674379
106Fair hair (HP:0002286)1.81669273
107Increased serum ferritin (HP:0003281)1.81606139
108Elevated hepatic transaminases (HP:0002910)1.81150567
109* Epistaxis (HP:0000421)1.80251533
110Renal cortical cysts (HP:0000803)1.79188957
111Abnormality of vitamin metabolism (HP:0100508)1.78514976
112Abnormal enzyme/coenzyme activity (HP:0012379)1.78389874
113Alkalosis (HP:0001948)1.76392486
114Hydroxyprolinuria (HP:0003080)1.76264756
115Abnormality of proline metabolism (HP:0010907)1.76264756
116Status epilepticus (HP:0002133)1.75357702
117Hyperphosphaturia (HP:0003109)1.74704126
118Abnormality of alkaline phosphatase activity (HP:0004379)1.74539409
119Hyperglycemia (HP:0003074)1.73871204
120Pulmonary embolism (HP:0002204)1.72122439
121Proximal tubulopathy (HP:0000114)1.71083606
122Pancreatic islet-cell hyperplasia (HP:0004510)1.64638235
123Reduced antithrombin III activity (HP:0001976)1.57206984
124Potter facies (HP:0002009)1.57189841
125Facial shape deformation (HP:0011334)1.57189841
126Flat acetabular roof (HP:0003180)1.55162213
127Abnormality of the nasal septum (HP:0000419)1.46812902
128Hematuria (HP:0000790)1.45817639
129Abnormal urine phosphate concentration (HP:0012599)1.45749076
130Hepatoblastoma (HP:0002884)1.45098037
131Abnormal hand bone ossification (HP:0010660)1.44815509
132Bifid scrotum (HP:0000048)1.41877231

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.92548658
2PDK25.71217786
3ERN14.82216640
4FGFR44.75866672
5SIK14.31627385
6ERBB43.19190834
7TAOK33.17345001
8INSRR3.05397972
9MAP2K42.30122043
10MST1R2.16809158
11WNK42.07998733
12MAPK112.02441003
13AKT32.01091411
14PKN21.99928246
15PDGFRA1.85575545
16PIK3CG1.85354382
17TRIB31.78968375
18TYK21.78197542
19FLT31.76436729
20CDK121.74066163
21LATS11.69212757
22DAPK21.67944644
23LMTK21.65052063
24MAP3K21.61561068
25PTK61.57376666
26FGFR11.54686792
27NEK91.50268220
28TYRO31.43574442
29ABL21.42898156
30NTRK31.41304435
31FRK1.35382623
32FGFR21.33177097
33JAK21.30979287
34KDR1.30893170
35EIF2AK11.24529138
36MAP3K71.16275489
37ERBB21.15631438
38PRKAA21.09840032
39JAK11.09385466
40TESK21.09244117
41EPHA31.09031937
42GRK61.07983864
43EPHB11.07865583
44TBK11.03785103
45PINK11.02180965
46MAP2K31.01397381
47MAP3K120.99686057
48MAPK40.95959619
49MAP3K140.94951210
50MAP3K100.93778115
51CSNK1E0.91214521
52MET0.90990880
53NLK0.90297250
54PRKCZ0.87781446
55MAP3K30.84109093
56MAPK150.82717893
57EPHA20.81978010
58ACVR1B0.81102400
59EIF2AK30.78668661
60MAPK120.78351967
61PRKACG0.78323185
62MAP3K110.77386775
63STK38L0.77132967
64SCYL20.76820057
65CDK60.76518944
66CAMK2G0.74817149
67TIE10.74782669
68CAMK1D0.71054261
69RIPK10.70577126
70KSR20.69392374
71DYRK1B0.69210326
72WNK10.68876320
73CSNK1D0.68658423
74FGFR30.67899998
75FER0.67194092
76CSK0.66591505
77GSK3A0.66504375
78NEK10.66292679
79MAPKAPK30.65438429
80PRKG10.65437721
81RPS6KB10.65433554
82PRKAA10.64880264
83SGK30.60465995
84MAP2K60.59021622
85FGR0.56906479
86TGFBR20.56722075
87PTK20.56521678
88MAPK70.54856863
89CSF1R0.54255200
90IRAK30.53335095
91IKBKE0.53152688
92CSNK2A20.50877994
93PKN10.50619149
94PDPK10.49665383
95PDGFRB0.47928356
96PRKCB0.47853363
97CSNK2A10.47810968
98PRKCQ0.47063841
99DDR20.44595336
100SGK10.44593251
101SGK20.44576566
102MAP2K10.44448206
103BCR0.43695744
104MAP3K50.42924163
105IGF1R0.42807925
106CSNK1G10.42666025
107CDK70.42551474
108GRK10.42078940
109SRC0.42020360
110BRSK20.41540183
111RET0.41414632
112EPHA40.39764558
113PRKCG0.39308340
114PRKACA0.38876536
115CDK90.38507461
116CDK40.38125727
117MAP3K130.37879605
118MTOR0.37705015
119TAOK20.37436547
120EGFR0.36551515
121PBK0.36382651
122ICK0.35570276
123MAP3K60.35173640
124RPS6KA30.34412339
125NEK60.34355355
126CAMK40.31838343
127BRD40.31688911
128MATK0.30769351
129CDC42BPA0.30750715
130SGK4940.30698648
131SGK2230.30698648
132MAP3K10.30467156
133PDK10.29239560
134IRAK10.28402022
135PIK3CA0.26018657
136PRKCA0.25276864
137LATS20.23781440
138CAMK1G0.23182609
139BMX0.22558527
140PRKACB0.21619694
141ABL10.21562596
142PAK30.21514140
143CSNK1G20.21284157
144MAPK30.18623073
145CSNK1G30.18089527

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.55217005
2Nitrogen metabolism_Homo sapiens_hsa009103.75352885
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.43995025
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.28107544
5Arginine biosynthesis_Homo sapiens_hsa002203.12292718
6* Complement and coagulation cascades_Homo sapiens_hsa046102.93802613
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.67569956
8Tryptophan metabolism_Homo sapiens_hsa003802.66069775
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.63496600
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.57729393
11Fatty acid degradation_Homo sapiens_hsa000712.47752136
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.34694003
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.17694067
14Butanoate metabolism_Homo sapiens_hsa006502.11921067
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.08814057
16Peroxisome_Homo sapiens_hsa041462.07058327
17Chemical carcinogenesis_Homo sapiens_hsa052041.91804995
18Propanoate metabolism_Homo sapiens_hsa006401.89790746
19Histidine metabolism_Homo sapiens_hsa003401.88955269
20PPAR signaling pathway_Homo sapiens_hsa033201.87366255
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.86992243
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.86522843
23Fatty acid metabolism_Homo sapiens_hsa012121.80013081
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.76314216
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.72307567
26* Staphylococcus aureus infection_Homo sapiens_hsa051501.71199910
27beta-Alanine metabolism_Homo sapiens_hsa004101.68035207
28Caffeine metabolism_Homo sapiens_hsa002321.67678522
29Retinol metabolism_Homo sapiens_hsa008301.64024109
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.63350530
31Selenocompound metabolism_Homo sapiens_hsa004501.59398492
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59003435
33Phenylalanine metabolism_Homo sapiens_hsa003601.56976567
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51478818
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50713967
36Bile secretion_Homo sapiens_hsa049761.47775950
37Tyrosine metabolism_Homo sapiens_hsa003501.44872199
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.33938540
39Pyruvate metabolism_Homo sapiens_hsa006201.33586348
40Sulfur metabolism_Homo sapiens_hsa009201.31428336
41Fatty acid elongation_Homo sapiens_hsa000621.30315912
42Starch and sucrose metabolism_Homo sapiens_hsa005001.26000534
43Steroid biosynthesis_Homo sapiens_hsa001001.22562444
44ABC transporters_Homo sapiens_hsa020101.21783137
45Fat digestion and absorption_Homo sapiens_hsa049751.21377710
46Biosynthesis of amino acids_Homo sapiens_hsa012301.21190132
47Folate biosynthesis_Homo sapiens_hsa007901.20762145
48Carbon metabolism_Homo sapiens_hsa012001.12486532
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.04911803
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03003083
51Vitamin B6 metabolism_Homo sapiens_hsa007501.00356519
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99704403
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.98122846
54Arginine and proline metabolism_Homo sapiens_hsa003300.95066253
55Sulfur relay system_Homo sapiens_hsa041220.93967461
56Vitamin digestion and absorption_Homo sapiens_hsa049770.89880357
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89571865
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83575948
59Lysine degradation_Homo sapiens_hsa003100.80238322
60One carbon pool by folate_Homo sapiens_hsa006700.78035451
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69426855
62Glycerolipid metabolism_Homo sapiens_hsa005610.65895676
63Glutathione metabolism_Homo sapiens_hsa004800.65159883
64Other glycan degradation_Homo sapiens_hsa005110.65141775
65Pentose phosphate pathway_Homo sapiens_hsa000300.58837920
66Fatty acid biosynthesis_Homo sapiens_hsa000610.53282953
67Metabolic pathways_Homo sapiens_hsa011000.45346546
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45209062
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44014135
70Prion diseases_Homo sapiens_hsa050200.40943466
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26573396
72Galactose metabolism_Homo sapiens_hsa000520.26228375
73Fructose and mannose metabolism_Homo sapiens_hsa000510.24313926
74Insulin resistance_Homo sapiens_hsa049310.23891197
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.22949346
76Linoleic acid metabolism_Homo sapiens_hsa005910.20070564
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19966958
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.15955928
79N-Glycan biosynthesis_Homo sapiens_hsa005100.13582375
80Sphingolipid metabolism_Homo sapiens_hsa006000.12634758
81Glucagon signaling pathway_Homo sapiens_hsa049220.10605957
82Mineral absorption_Homo sapiens_hsa049780.07169737
83AMPK signaling pathway_Homo sapiens_hsa041520.01846132
84Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2434851
85Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2352632
86Pertussis_Homo sapiens_hsa05133-0.2347249
87Amoebiasis_Homo sapiens_hsa05146-0.2240875
88Bladder cancer_Homo sapiens_hsa05219-0.2104474
89Protein digestion and absorption_Homo sapiens_hsa04974-0.2053247
90Lysosome_Homo sapiens_hsa04142-0.2043814
91Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1846701
92Renin-angiotensin system_Homo sapiens_hsa04614-0.1792498
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1750836
94Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1729152
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1650633
96Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1570038
97Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1523234
98Hepatitis C_Homo sapiens_hsa05160-0.1517386
99Regulation of autophagy_Homo sapiens_hsa04140-0.1483966
100Other types of O-glycan biosynthesis_Homo sapiens_hsa00514-0.1356163
101Ether lipid metabolism_Homo sapiens_hsa00565-0.1346541
102African trypanosomiasis_Homo sapiens_hsa05143-0.1246429
103ECM-receptor interaction_Homo sapiens_hsa04512-0.1118101
104Insulin signaling pathway_Homo sapiens_hsa04910-0.1036639
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0829039
106Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0758002
107Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0734900
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0572359
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0556234

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