FGGY

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that phosphorylates carbohydrates such as ribulose, ribitol, and L-arabinitol. Genome-wide association studies in some populations have found an association between polymorphisms in this gene and sporadic amyotrophic lateral sclerosis, but studies of other populations have not been able to replicate this association. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.52328689
2L-phenylalanine catabolic process (GO:0006559)7.52328689
3L-phenylalanine metabolic process (GO:0006558)7.23988020
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.23988020
5aromatic amino acid family catabolic process (GO:0009074)6.79598550
6indole-containing compound catabolic process (GO:0042436)6.14442852
7indolalkylamine catabolic process (GO:0046218)6.14442852
8tryptophan catabolic process (GO:0006569)6.14442852
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.93307569
10kynurenine metabolic process (GO:0070189)5.92411805
11glyoxylate metabolic process (GO:0046487)5.84809394
12bile acid biosynthetic process (GO:0006699)5.83366650
13tryptophan metabolic process (GO:0006568)5.79663093
14alpha-linolenic acid metabolic process (GO:0036109)5.47750119
15cysteine metabolic process (GO:0006534)5.44449991
16exogenous drug catabolic process (GO:0042738)5.31648764
17sulfur amino acid catabolic process (GO:0000098)5.31102075
18urea metabolic process (GO:0019627)5.28223926
19urea cycle (GO:0000050)5.28223926
20high-density lipoprotein particle remodeling (GO:0034375)5.22937486
21negative regulation of fibrinolysis (GO:0051918)5.16149705
22protein carboxylation (GO:0018214)5.09207198
23peptidyl-glutamic acid carboxylation (GO:0017187)5.09207198
24complement activation, alternative pathway (GO:0006957)5.05196693
25serine family amino acid catabolic process (GO:0009071)5.04034484
26regulation of fibrinolysis (GO:0051917)5.01694440
27regulation of protein activation cascade (GO:2000257)4.97957460
28aromatic amino acid family metabolic process (GO:0009072)4.94516976
29homocysteine metabolic process (GO:0050667)4.94449747
30fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.93055260
31bile acid metabolic process (GO:0008206)4.92978454
32nitrogen cycle metabolic process (GO:0071941)4.89223141
33lysine catabolic process (GO:0006554)4.83369549
34lysine metabolic process (GO:0006553)4.83369549
35tyrosine metabolic process (GO:0006570)4.65916333
36regulation of complement activation (GO:0030449)4.65484550
37reverse cholesterol transport (GO:0043691)4.64485351
38oxidative demethylation (GO:0070989)4.63837125
39amino-acid betaine metabolic process (GO:0006577)4.63784917
40alpha-amino acid catabolic process (GO:1901606)4.61876449
41regulation of cholesterol esterification (GO:0010872)4.54528852
42protein-lipid complex remodeling (GO:0034368)4.51710880
43macromolecular complex remodeling (GO:0034367)4.51710880
44plasma lipoprotein particle remodeling (GO:0034369)4.51710880
45regulation of triglyceride catabolic process (GO:0010896)4.45700073
46cellular ketone body metabolic process (GO:0046950)4.41016869
47indolalkylamine metabolic process (GO:0006586)4.38573728
48triglyceride homeostasis (GO:0070328)4.34752695
49acylglycerol homeostasis (GO:0055090)4.34752695
50coenzyme catabolic process (GO:0009109)4.30683788
51cellular amino acid catabolic process (GO:0009063)4.29803659
52amine catabolic process (GO:0009310)4.29455852
53cellular biogenic amine catabolic process (GO:0042402)4.29455852
54negative regulation of sterol transport (GO:0032372)4.25153643
55negative regulation of cholesterol transport (GO:0032375)4.25153643
56phospholipid efflux (GO:0033700)4.22652707
57glutamate metabolic process (GO:0006536)4.21175523
58plasma lipoprotein particle clearance (GO:0034381)4.19187495
59cellular modified amino acid catabolic process (GO:0042219)4.15754532
60aldehyde catabolic process (GO:0046185)4.15414101
61serine family amino acid metabolic process (GO:0009069)4.12973204
62cellular glucuronidation (GO:0052695)4.12511623
63glycine metabolic process (GO:0006544)4.12051620
64benzene-containing compound metabolic process (GO:0042537)4.10950799
65bile acid and bile salt transport (GO:0015721)4.10284329
66imidazole-containing compound metabolic process (GO:0052803)4.09321149
67ethanol oxidation (GO:0006069)4.06333741
68epoxygenase P450 pathway (GO:0019373)4.04215886
69cholesterol efflux (GO:0033344)4.00402128
70short-chain fatty acid metabolic process (GO:0046459)4.00312602
71omega-hydroxylase P450 pathway (GO:0097267)3.97934214
72drug catabolic process (GO:0042737)3.93953906
73detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.93547756
74low-density lipoprotein particle remodeling (GO:0034374)3.91614830
75dicarboxylic acid biosynthetic process (GO:0043650)3.90914538
76serine family amino acid biosynthetic process (GO:0009070)3.89914109
77arginine metabolic process (GO:0006525)3.86033068
78L-methionine salvage (GO:0071267)3.84039134
79L-methionine biosynthetic process (GO:0071265)3.84039134
80amino acid salvage (GO:0043102)3.84039134
81carboxylic acid catabolic process (GO:0046395)3.81914616
82organic acid catabolic process (GO:0016054)3.81914616
83xenobiotic catabolic process (GO:0042178)3.81294955
84ketone body metabolic process (GO:1902224)3.81011176
85urate metabolic process (GO:0046415)3.80956492
86drug transmembrane transport (GO:0006855)3.79365374
87acetyl-CoA metabolic process (GO:0006084)3.79353767
88plasma lipoprotein particle assembly (GO:0034377)3.78358021
89fibrinolysis (GO:0042730)3.75545139
90uronic acid metabolic process (GO:0006063)3.74175613
91glucuronate metabolic process (GO:0019585)3.74175613
92cofactor catabolic process (GO:0051187)3.72379488
93phenylpropanoid metabolic process (GO:0009698)3.71829880
94blood coagulation, intrinsic pathway (GO:0007597)3.65405343
95aspartate family amino acid catabolic process (GO:0009068)3.62594335
96NAD biosynthetic process (GO:0009435)3.62534176
97cilium or flagellum-dependent cell motility (GO:0001539)3.62045494
98phospholipid homeostasis (GO:0055091)3.61125835
99very-low-density lipoprotein particle assembly (GO:0034379)3.60191025
100monocarboxylic acid catabolic process (GO:0072329)3.58671968
101cholesterol homeostasis (GO:0042632)3.56707196
102fatty acid beta-oxidation (GO:0006635)3.56398367
103pyridine nucleotide biosynthetic process (GO:0019363)3.56189364
104nicotinamide nucleotide biosynthetic process (GO:0019359)3.56189364
105complement activation, classical pathway (GO:0006958)3.55574901
106fatty acid oxidation (GO:0019395)3.55417656
107drug metabolic process (GO:0017144)3.55346632
108positive regulation of lipid catabolic process (GO:0050996)3.55167258
109flavonoid metabolic process (GO:0009812)3.54861049
1102-oxoglutarate metabolic process (GO:0006103)3.54602327
111protein activation cascade (GO:0072376)3.52763474
112complement activation (GO:0006956)3.51227967
113signal peptide processing (GO:0006465)3.48066331
114regulation of skeletal muscle contraction (GO:0014819)3.46197047
115negative regulation of protein activation cascade (GO:2000258)3.40175669
116L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.39403106
117negative regulation of complement activation (GO:0045916)3.38081626
118regulation of glucokinase activity (GO:0033131)3.35813251
119regulation of hexokinase activity (GO:1903299)3.35813251
120epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.33111096
121S-adenosylmethionine metabolic process (GO:0046500)3.27271619
122water-soluble vitamin biosynthetic process (GO:0042364)3.18475724
123response to nitrosative stress (GO:0051409)3.11491476
124indole-containing compound metabolic process (GO:0042430)3.07505548
125methionine biosynthetic process (GO:0009086)3.05158120
126detection of light stimulus involved in visual perception (GO:0050908)2.94845052
127detection of light stimulus involved in sensory perception (GO:0050962)2.94845052
128photoreceptor cell maintenance (GO:0045494)2.91231008
129branched-chain amino acid catabolic process (GO:0009083)2.90900693
130methionine metabolic process (GO:0006555)2.87316442
131alkaloid metabolic process (GO:0009820)2.84216874
132dopamine transport (GO:0015872)2.78715427
133branched-chain amino acid metabolic process (GO:0009081)2.76908726
134epithelial cilium movement (GO:0003351)2.76214486
135arginine catabolic process (GO:0006527)2.76078907
136axoneme assembly (GO:0035082)2.75506707
137C4-dicarboxylate transport (GO:0015740)2.68278779
138thyroid hormone metabolic process (GO:0042403)2.68082217
139cilium movement (GO:0003341)2.66556736
140carnitine metabolic process (GO:0009437)2.58861528
141protein K11-linked deubiquitination (GO:0035871)2.58641932
142auditory receptor cell stereocilium organization (GO:0060088)2.57803927
143protein prenylation (GO:0018342)2.56382851
144prenylation (GO:0097354)2.56382851
145xenobiotic metabolic process (GO:0006805)2.56038410
146regulation of sarcomere organization (GO:0060297)2.50965885
147negative regulation of cytosolic calcium ion concentration (GO:0051481)2.49908540
148negative regulation of humoral immune response (GO:0002921)2.49672451

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.16366917
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.93167965
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.89773331
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.34671933
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.18836865
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.01227938
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.00396466
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.07179643
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.81370601
10GBX2_23144817_ChIP-Seq_PC3_Human3.60805428
11IGF1R_20145208_ChIP-Seq_DFB_Human3.05618874
12VDR_22108803_ChIP-Seq_LS180_Human2.69893774
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.62331648
14ZNF274_21170338_ChIP-Seq_K562_Hela2.62003821
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.57190759
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.49971650
17* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.40480078
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.28639326
19* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.20386465
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12440979
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.03698975
22ER_23166858_ChIP-Seq_MCF-7_Human2.02997872
23* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.01196801
24* P300_19829295_ChIP-Seq_ESCs_Human2.00359368
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.6120654
26* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97728327
27* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.97680362
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.92708584
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92064632
30* SMAD4_21799915_ChIP-Seq_A2780_Human1.83834965
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.78135021
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77634472
33EWS_26573619_Chip-Seq_HEK293_Human1.77040964
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74223147
35* STAT3_23295773_ChIP-Seq_U87_Human1.73335225
36* BCAT_22108803_ChIP-Seq_LS180_Human1.73017648
37FUS_26573619_Chip-Seq_HEK293_Human1.71534959
38EZH2_27294783_Chip-Seq_NPCs_Mouse1.70327052
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.69496835
40EZH2_22144423_ChIP-Seq_EOC_Human1.69268189
41* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.66478398
42CBP_20019798_ChIP-Seq_JUKART_Human1.65298173
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.65298173
44HTT_18923047_ChIP-ChIP_STHdh_Human1.64895452
45CLOCK_20551151_ChIP-Seq_293T_Human1.56263548
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.55500498
47* TCF4_23295773_ChIP-Seq_U87_Human1.55351072
48* FOXA2_19822575_ChIP-Seq_HepG2_Human1.54381664
49* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.52841979
50GATA1_22025678_ChIP-Seq_K562_Human1.51867159
51* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47708961
52* AR_25329375_ChIP-Seq_VCAP_Human1.47698633
53* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45701622
54* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45150052
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44228625
56SOX2_19829295_ChIP-Seq_ESCs_Human1.43942240
57NANOG_19829295_ChIP-Seq_ESCs_Human1.43942240
58CRX_20693478_ChIP-Seq_RETINA_Mouse1.43747089
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43318791
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42368490
61KLF5_20875108_ChIP-Seq_MESCs_Mouse1.40030606
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38429780
63* TCF4_22108803_ChIP-Seq_LS180_Human1.36917515
64* HNF4A_19822575_ChIP-Seq_HepG2_Human1.35884856
65STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.34827664
66* SMAD3_21741376_ChIP-Seq_EPCs_Human1.33643077
67* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32903523
68FOXA1_21572438_ChIP-Seq_LNCaP_Human1.32328194
69* NANOG_18555785_Chip-Seq_ESCs_Mouse1.30485633
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29382939
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.28861478
72* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28654961
73THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24299801
74OCT4_21477851_ChIP-Seq_ESCs_Mouse1.24112107
75IRF8_22096565_ChIP-ChIP_GC-B_Human1.23707337
76* SMAD4_21741376_ChIP-Seq_EPCs_Human1.23238273
77* RUNX2_22187159_ChIP-Seq_PCA_Human1.22801125
78P53_22387025_ChIP-Seq_ESCs_Mouse1.22686683
79TP53_22573176_ChIP-Seq_HFKS_Human1.21523456
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20706255
81IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.20645080
82E2F1_18555785_Chip-Seq_ESCs_Mouse1.18893185
83FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18188621
84FOXA1_25329375_ChIP-Seq_VCAP_Human1.18188621
85FOXM1_26456572_ChIP-Seq_MCF-7_Human1.15486474
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14786474
87RXRA_24833708_ChIP-Seq_LIVER_Mouse1.14733497
88STAT3_18555785_Chip-Seq_ESCs_Mouse1.14657633
89RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11787841
90TP53_16413492_ChIP-PET_HCT116_Human1.10678202
91SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09209232
92FLI1_21867929_ChIP-Seq_TH2_Mouse1.08919938
93SALL1_21062744_ChIP-ChIP_HESCs_Human1.08183291
94TAL1_26923725_Chip-Seq_HPCs_Mouse1.07990466
95* PHF8_20622853_ChIP-Seq_HELA_Human1.06744756
96* PRDM14_20953172_ChIP-Seq_ESCs_Human1.06455153
97* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06432857
98P300_18555785_Chip-Seq_ESCs_Mouse1.06066749
99ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05337267
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05171715
101POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05171715
102* NCOR_22424771_ChIP-Seq_293T_Human1.05138996
103CMYC_18555785_Chip-Seq_ESCs_Mouse1.03545047
104* ETV1_20927104_ChIP-Seq_GIST48_Human1.03475719
105PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02851119
106* NFYB_21822215_ChIP-Seq_K562_Human1.02035481
107* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.01579076
108STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01046824
109* TBL1_22424771_ChIP-Seq_293T_Human1.00197628
110TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99719204
111PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94009404
112SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93949199
113ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91409392
114Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.87694613
115RARG_19884340_ChIP-ChIP_MEFs_Mouse0.84148767
116AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83309210
117ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.81459312
118BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81166229
119KAP1_22055183_ChIP-Seq_ESCs_Mouse0.80853828
120GATA4_25053715_ChIP-Seq_YYC3_Human0.80591492
121NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.78960892
122NRF2_20460467_ChIP-Seq_MEFs_Mouse0.78960892
123SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77330652
124CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.75683122
125TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.74270104
126ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.72523492
127BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.72119105
128SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.71232035
129AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.71149821
130AR_20517297_ChIP-Seq_VCAP_Human0.69473333
131RAD21_21589869_ChIP-Seq_MESCs_Mouse0.69287126
132RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.67836973
133NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.67637142
134SALL4_18804426_ChIP-ChIP_XEN_Mouse0.67629551
135RARA_24833708_ChIP-Seq_LIVER_Mouse0.65675195
136ESR2_21235772_ChIP-Seq_MCF-7_Human0.62729595
137CEBPB_22108803_ChIP-Seq_LS180_Human0.59805566
138PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.57352529
139TAF15_26573619_Chip-Seq_HEK293_Human0.57079506
140RARB_24833708_ChIP-Seq_LIVER_Mouse0.56859404
141ESR1_21235772_ChIP-Seq_MCF-7_Human0.56664164
142CBP_21632823_ChIP-Seq_H3396_Human0.56097936
143NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.56080632
144FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.55709000
145MYC_19915707_ChIP-ChIP_AK7_Human0.55536920
146ESET_19884257_ChIP-Seq_ESCs_Mouse0.54920952
147FOXA1_25552417_ChIP-Seq_VCAP_Human0.54571264
148EGR1_19032775_ChIP-ChIP_M12_Human0.54108577
149* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.53206899
150STAT1_17558387_ChIP-Seq_HELA_Human0.52333875
151PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.51655438
152STAT3_1855785_ChIP-Seq_MESCs_Mouse0.49316414
153FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.46840343
154SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.45822302
155PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.45708077
156TAF2_19829295_ChIP-Seq_ESCs_Human0.44458384
157LXR_22292898_ChIP-Seq_THP-1_Human0.44101009
158ERG_20517297_ChIP-Seq_VCAP_Human0.43444358
159FOXH1_21741376_ChIP-Seq_EPCs_Human0.43405658
160PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.43244360
161GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.42888846
162SOX2_20726797_ChIP-Seq_SW620_Human0.42705698
163FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.42488575
164P53_21459846_ChIP-Seq_SAOS-2_Human0.42282896
165GATA2_19941826_ChIP-Seq_K562_Human0.42167960
166GATA1_19941826_ChIP-Seq_K562_Human0.41928181
167GATA1_19941827_ChIP-Seq_MEL_Mouse0.41887224
168NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.41767233
169EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.40229033
170CDX2_20551321_ChIP-Seq_CACO-2_Human0.39859083
171SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.39832949
172* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.39492552
173CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.38675684
174PPAR_26484153_Chip-Seq_NCI-H1993_Human0.37843432
175E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.37824899
176OCT4_20526341_ChIP-Seq_ESCs_Human0.36990470
177STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.36947520
178SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.36763700
179LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.36622418
180* CDX2_22108803_ChIP-Seq_LS180_Human0.36503350
181RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.36496676
182FOXO3_23340844_ChIP-Seq_DLD1_Human0.36224374
183ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.35855069
184CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.35141891

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.10785498
2MP0005360_urolithiasis7.50594181
3MP0005085_abnormal_gallbladder_physiolo6.22178053
4MP0005365_abnormal_bile_salt5.99981733
5MP0008875_abnormal_xenobiotic_pharmacok4.97671614
6MP0003806_abnormal_nucleotide_metabolis4.27660256
7MP0003252_abnormal_bile_duct3.78987174
8MP0010329_abnormal_lipoprotein_level3.48719824
9MP0003646_muscle_fatigue3.26559508
10MP0003195_calcinosis3.15324783
11MP0009840_abnormal_foam_cell3.08517576
12MP0005332_abnormal_amino_acid3.07635173
13MP0005083_abnormal_biliary_tract2.87573145
14MP0004145_abnormal_muscle_electrophysio2.70279539
15MP0001666_abnormal_nutrient_absorption2.53150662
16MP0004019_abnormal_vitamin_homeostasis2.34819099
17MP0003191_abnormal_cellular_cholesterol2.26946219
18MP0005551_abnormal_eye_electrophysiolog2.15207231
19MP0002138_abnormal_hepatobiliary_system2.14136495
20MP0000569_abnormal_digit_pigmentation2.12666177
21MP0000609_abnormal_liver_physiology2.09466707
22MP0002118_abnormal_lipid_homeostasis2.09276312
23MP0003950_abnormal_plasma_membrane2.04718063
24MP0000372_irregular_coat_pigmentation1.97086745
25MP0005319_abnormal_enzyme/_coenzyme1.87651089
26MP0003868_abnormal_feces_composition1.86813422
27MP0001764_abnormal_homeostasis1.73265316
28MP0009697_abnormal_copulation1.67170811
29MP0005584_abnormal_enzyme/coenzyme_acti1.65673218
30MP0002638_abnormal_pupillary_reflex1.63096382
31MP0010386_abnormal_urinary_bladder1.59329375
32MP0009643_abnormal_urine_homeostasis1.53164836
33MP0008877_abnormal_DNA_methylation1.51549549
34MP0001984_abnormal_olfaction1.51134610
35MP0003186_abnormal_redox_activity1.49757705
36MP0009046_muscle_twitch1.43603167
37MP0000427_abnormal_hair_cycle1.40439271
38MP0001501_abnormal_sleep_pattern1.37138341
39MP0005253_abnormal_eye_physiology1.34535220
40MP0003011_delayed_dark_adaptation1.34379992
41MP0005646_abnormal_pituitary_gland1.30699378
42MP0005451_abnormal_body_composition1.30650581
43MP0004215_abnormal_myocardial_fiber1.29581639
44MP0004036_abnormal_muscle_relaxation1.29057433
45MP0004142_abnormal_muscle_tone1.25273725
46MP0000749_muscle_degeneration1.24099477
47MP0002102_abnormal_ear_morphology1.20328649
48MP0008057_abnormal_DNA_replication1.19326420
49MP0001485_abnormal_pinna_reflex1.18215800
50MP0009764_decreased_sensitivity_to1.16414632
51MP0005645_abnormal_hypothalamus_physiol1.16151027
52MP0000598_abnormal_liver_morphology1.15110848
53MP0003656_abnormal_erythrocyte_physiolo1.11829373
54MP0005636_abnormal_mineral_homeostasis1.10950800
55MP0005647_abnormal_sex_gland1.10785617
56MP0004147_increased_porphyrin_level1.10484973
57MP0003136_yellow_coat_color1.10221450
58MP0002332_abnormal_exercise_endurance1.10137933
59MP0000604_amyloidosis1.09270943
60MP0002876_abnormal_thyroid_physiology1.07134629
61MP0005379_endocrine/exocrine_gland_phen1.06949540
62MP0002090_abnormal_vision1.03262750
63MP0005670_abnormal_white_adipose1.03169349
64MP0009745_abnormal_behavioral_response1.02662427
65MP0005410_abnormal_fertilization1.02068134
66MP0006276_abnormal_autonomic_nervous1.01396615
67MP0006072_abnormal_retinal_apoptosis1.01231077
68MP0009763_increased_sensitivity_to1.00672096
69MP0003787_abnormal_imprinting1.00507725
70MP0001986_abnormal_taste_sensitivity0.99897554
71MP0001968_abnormal_touch/_nociception0.97853680
72MP0002736_abnormal_nociception_after0.97734847
73MP0004084_abnormal_cardiac_muscle0.96722259
74MP0003705_abnormal_hypodermis_morpholog0.96369850
75MP0008469_abnormal_protein_level0.95448927
76MP0005084_abnormal_gallbladder_morpholo0.93526989
77MP0002254_reproductive_system_inflammat0.93339545
78MP0006036_abnormal_mitochondrial_physio0.91770702
79MP0009642_abnormal_blood_homeostasis0.91370856
80MP0005408_hypopigmentation0.89516066
81MP0005620_abnormal_muscle_contractility0.87976742
82MP0003690_abnormal_glial_cell0.86081984
83MP0000383_abnormal_hair_follicle0.85221163
84MP0002938_white_spotting0.84668871
85MP0002078_abnormal_glucose_homeostasis0.83986590
86MP0003137_abnormal_impulse_conducting0.83959236
87MP0001486_abnormal_startle_reflex0.83419642
88MP0002229_neurodegeneration0.82041685
89MP0002272_abnormal_nervous_system0.82024467
90MP0003879_abnormal_hair_cell0.81909159
91MP0005376_homeostasis/metabolism_phenot0.81184599
92MP0005220_abnormal_exocrine_pancreas0.80002363
93MP0005535_abnormal_body_temperature0.79655401
94MP0004130_abnormal_muscle_cell0.79507395
95MP0009765_abnormal_xenobiotic_induced0.79502842
96MP0002971_abnormal_brown_adipose0.78092849
97MP0001756_abnormal_urination0.77657885
98MP0010368_abnormal_lymphatic_system0.77162992
99MP0005174_abnormal_tail_pigmentation0.75531878
100MP0002269_muscular_atrophy0.74894191
101MP0005187_abnormal_penis_morphology0.74801076
102MP0001661_extended_life_span0.72230542
103MP0003633_abnormal_nervous_system0.71419889
104MP0005334_abnormal_fat_pad0.71137317
105MP0005058_abnormal_lysosome_morphology0.69609073
106MP0002693_abnormal_pancreas_physiology0.68950541
107MP0004085_abnormal_heartbeat0.68618776
108MP0000631_abnormal_neuroendocrine_gland0.66505201
109MP0005266_abnormal_metabolism0.66107370
110MP0003329_amyloid_beta_deposits0.65763764
111MP0002136_abnormal_kidney_physiology0.65722406
112MP0002106_abnormal_muscle_physiology0.64853157
113MP0004885_abnormal_endolymph0.64030576
114MP0002067_abnormal_sensory_capabilities0.63599007
115MP0004043_abnormal_pH_regulation0.62887925
116MP0006035_abnormal_mitochondrial_morpho0.61299400
117MP0000639_abnormal_adrenal_gland0.57987012
118MP0002928_abnormal_bile_duct0.57188679
119MP0003724_increased_susceptibility_to0.56567160
120MP0005448_abnormal_energy_balance0.56403454
121MP0005464_abnormal_platelet_physiology0.54730015
122MP0003638_abnormal_response/metabolism_0.52511953
123MP0005666_abnormal_adipose_tissue0.51170510
124MP0005395_other_phenotype0.48235750
125MP0003953_abnormal_hormone_level0.47331260
126MP0003075_altered_response_to0.47153770
127MP0004782_abnormal_surfactant_physiolog0.45603505
128MP0008874_decreased_physiological_sensi0.45032062
129MP0000230_abnormal_systemic_arterial0.43387335
130MP0009384_cardiac_valve_regurgitation0.41849455
131MP0008873_increased_physiological_sensi0.41647986
132MP0001765_abnormal_ion_homeostasis0.40057326
133MP0003718_maternal_effect0.39599991
134MP0005166_decreased_susceptibility_to0.38925956
135MP0001853_heart_inflammation0.38638122
136MP0003436_decreased_susceptibility_to0.38241705
137MP0009053_abnormal_anal_canal0.38029823
138MP0002837_dystrophic_cardiac_calcinosis0.37901282
139MP0006082_CNS_inflammation0.37595031
140MP0002822_catalepsy0.37422756
141MP0002168_other_aberrant_phenotype0.36433599
142MP0008872_abnormal_physiological_respon0.36222241
143MP0009115_abnormal_fat_cell0.34032329
144MP0009672_abnormal_birth_weight0.33896269
145MP0001845_abnormal_inflammatory_respons0.32966910
146MP0003959_abnormal_lean_body0.32731329
147MP0000249_abnormal_blood_vessel0.32423368
148MP0002970_abnormal_white_adipose0.31351025
149MP0004381_abnormal_hair_follicle0.30106526
150MP0002135_abnormal_kidney_morphology0.29459194
151MP0002796_impaired_skin_barrier0.29184547
152MP0005595_abnormal_vascular_smooth0.28812025
153MP0000538_abnormal_urinary_bladder0.28668567
154MP0005164_abnormal_response_to0.25844168
155MP0001944_abnormal_pancreas_morphology0.25230515

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.42298225
2Intrahepatic cholestasis (HP:0001406)6.86421195
3Deep venous thrombosis (HP:0002625)6.72878142
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.19530761
5Prolonged partial thromboplastin time (HP:0003645)6.17484499
6Xanthomatosis (HP:0000991)6.00840629
7Hypobetalipoproteinemia (HP:0003563)5.79458079
8Hyperlipoproteinemia (HP:0010980)5.16719017
9Complement deficiency (HP:0004431)5.03159201
10Hyperammonemia (HP:0001987)4.58617932
11Hyperglycinemia (HP:0002154)4.57850993
12Joint hemorrhage (HP:0005261)4.57845483
13Ketosis (HP:0001946)4.52121454
14Hypolipoproteinemia (HP:0010981)4.41511052
15Abnormality of glutamine family amino acid metabolism (HP:0010902)4.36269431
16Hyperglycinuria (HP:0003108)4.29915661
17Abnormality of serine family amino acid metabolism (HP:0010894)4.26282601
18Abnormality of glycine metabolism (HP:0010895)4.26282601
19Abnormality of aspartate family amino acid metabolism (HP:0010899)4.22513336
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.19941336
21Epidermoid cyst (HP:0200040)4.17163498
22Abnormality of the common coagulation pathway (HP:0010990)4.17093895
23Abnormality of methionine metabolism (HP:0010901)4.06325698
24Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.05974273
25Hypoglycemic coma (HP:0001325)3.96838928
26Hypoalphalipoproteinemia (HP:0003233)3.91909044
27Fat malabsorption (HP:0002630)3.90255307
28Pancreatic cysts (HP:0001737)3.89885227
29Abnormality of the intrinsic pathway (HP:0010989)3.71893783
30Pancreatic fibrosis (HP:0100732)3.66448827
31Abnormality of complement system (HP:0005339)3.62969305
32Abnormality of pyrimidine metabolism (HP:0004353)3.56869257
33Abnormality of fatty-acid metabolism (HP:0004359)3.55695956
34True hermaphroditism (HP:0010459)3.52401482
35Ketoacidosis (HP:0001993)3.47021463
36Nemaline bodies (HP:0003798)3.46228183
37Conjugated hyperbilirubinemia (HP:0002908)3.43550336
38Muscle fiber inclusion bodies (HP:0100299)3.42159676
39Hypercholesterolemia (HP:0003124)3.40358656
40Abnormality of midbrain morphology (HP:0002418)3.31820008
41Molar tooth sign on MRI (HP:0002419)3.31820008
42Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.30760497
43Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.29051606
44Delayed CNS myelination (HP:0002188)3.22327665
45Abnormality of nucleobase metabolism (HP:0010932)3.20592397
46Hyperbilirubinemia (HP:0002904)3.17896633
47Abnormality of serum amino acid levels (HP:0003112)3.16862614
48Abnormality of the renal cortex (HP:0011035)3.14208129
49Abnormal biliary tract physiology (HP:0012439)3.09853799
50Bile duct proliferation (HP:0001408)3.09853799
51Abnormality of purine metabolism (HP:0004352)3.02453967
52Steatorrhea (HP:0002570)2.97768010
53Attenuation of retinal blood vessels (HP:0007843)2.97638943
54Gout (HP:0001997)2.93425711
55Hyperventilation (HP:0002883)2.87821208
56Abnormality of dicarboxylic acid metabolism (HP:0010995)2.87283974
57Dicarboxylic aciduria (HP:0003215)2.87283974
58Metabolic acidosis (HP:0001942)2.86456628
59Nephronophthisis (HP:0000090)2.81558552
60Hepatocellular carcinoma (HP:0001402)2.81053222
61Myocardial infarction (HP:0001658)2.77745532
62Spontaneous abortion (HP:0005268)2.77051770
63Gaze-evoked nystagmus (HP:0000640)2.76338868
64Generalized aminoaciduria (HP:0002909)2.74989478
65Fair hair (HP:0002286)2.74752738
66Lethargy (HP:0001254)2.72980384
67Systemic lupus erythematosus (HP:0002725)2.72599145
68Muscle hypertrophy of the lower extremities (HP:0008968)2.72539825
69Calf muscle hypertrophy (HP:0008981)2.69224129
70Vascular calcification (HP:0004934)2.65909430
71Abnormality of the renal medulla (HP:0100957)2.64379786
72Hypoglycemic seizures (HP:0002173)2.63417816
73Skin nodule (HP:0200036)2.62741944
74Large for gestational age (HP:0001520)2.51141613
75Hypochromic microcytic anemia (HP:0004840)2.50729752
76Medial flaring of the eyebrow (HP:0010747)2.50305222
77Chronic hepatic failure (HP:0100626)2.50291106
78Cerebral edema (HP:0002181)2.50095635
79Abnormality of alanine metabolism (HP:0010916)2.47701141
80Hyperalaninemia (HP:0003348)2.47701141
81Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.47701141
82Irritability (HP:0000737)2.44955037
83Cystic liver disease (HP:0006706)2.43942496
84Congenital sensorineural hearing impairment (HP:0008527)2.42406333
85Hypothermia (HP:0002045)2.38473813
86Exercise-induced muscle cramps (HP:0003710)2.38078086
87Mitral stenosis (HP:0001718)2.35253217
88Enlarged kidneys (HP:0000105)2.34579149
89Cardiovascular calcification (HP:0011915)2.34532704
90Neonatal onset (HP:0003623)2.34137516
91Alkalosis (HP:0001948)2.33039058
92Spastic diplegia (HP:0001264)2.32235492
93Glomerulonephritis (HP:0000099)2.29626299
94Abnormal ciliary motility (HP:0012262)2.29606312
95Acute encephalopathy (HP:0006846)2.28521255
96Vomiting (HP:0002013)2.27898523
97Aplasia/Hypoplasia of the tongue (HP:0010295)2.26871943
98Pancreatitis (HP:0001733)2.26515456
99Recurrent gram-negative bacterial infections (HP:0005420)2.26057725
100Acanthocytosis (HP:0001927)2.25868834
101Abnormal gallbladder morphology (HP:0012437)2.25819567
102Sensorimotor neuropathy (HP:0007141)2.23772659
103Abolished electroretinogram (ERG) (HP:0000550)2.23513870
104Proximal tubulopathy (HP:0000114)2.22501219
105Congenital stationary night blindness (HP:0007642)2.21831297
106Late onset (HP:0003584)2.20988787
107Absent/shortened dynein arms (HP:0200106)2.18785252
108Dynein arm defect of respiratory motile cilia (HP:0012255)2.18785252
109Malnutrition (HP:0004395)2.18532021
110Hyperinsulinemic hypoglycemia (HP:0000825)2.18447830
111Amyloidosis (HP:0011034)2.17109776
112Furrowed tongue (HP:0000221)2.16716466
113Cholelithiasis (HP:0001081)2.14920229
114Abnormality of proline metabolism (HP:0010907)2.13036589
115Hydroxyprolinuria (HP:0003080)2.13036589
116Opisthotonus (HP:0002179)2.12264472
117Increased purine levels (HP:0004368)2.10687533
118Hyperuricemia (HP:0002149)2.10687533
119Menorrhagia (HP:0000132)2.09212465
120Abnormal gallbladder physiology (HP:0012438)2.07799821
121Cholecystitis (HP:0001082)2.07799821
122Rickets (HP:0002748)2.07168127
123Tubular atrophy (HP:0000092)2.07076190
124Progressive cerebellar ataxia (HP:0002073)2.05420381
125Abnormality of urine glucose concentration (HP:0011016)2.05392793
126Glycosuria (HP:0003076)2.05392793
127Congenital hepatic fibrosis (HP:0002612)2.04430435
128Brushfield spots (HP:0001088)2.03555742
129Esophageal varix (HP:0002040)2.03513106
130Gingival bleeding (HP:0000225)2.01649681
131Thrombophlebitis (HP:0004418)2.00737112
132Aplasia/Hypoplasia of the tibia (HP:0005772)1.99957620
133Abnormal drinking behavior (HP:0030082)1.96700649
134Polydipsia (HP:0001959)1.96700649
135Acute necrotizing encephalopathy (HP:0006965)1.96451061
136Generalized hypopigmentation of hair (HP:0011358)1.95953960
137Hemorrhage of the eye (HP:0011885)1.95606543
138Decreased central vision (HP:0007663)1.95463567
139Symptomatic seizures (HP:0011145)1.94958217
140Abnormal respiratory motile cilium physiology (HP:0012261)1.94631646
141Hypophosphatemic rickets (HP:0004912)1.93794143
142Abnormal enzyme/coenzyme activity (HP:0012379)1.92723341
143Hyperkalemia (HP:0002153)1.92460463
144Abnormal respiratory epithelium morphology (HP:0012253)1.92176216
145Abnormal respiratory motile cilium morphology (HP:0005938)1.92176216
146Congenital primary aphakia (HP:0007707)1.89853858
147Progressive macrocephaly (HP:0004481)1.88252581
148Nephrogenic diabetes insipidus (HP:0009806)1.87959889
149Elevated hepatic transaminases (HP:0002910)1.87204555
150Increased CSF lactate (HP:0002490)1.87076679
151Bony spicule pigmentary retinopathy (HP:0007737)1.86695762
152Abnormality of vitamin metabolism (HP:0100508)1.84707007
153Abnormality of the gallbladder (HP:0005264)1.84318925
154Male pseudohermaphroditism (HP:0000037)1.83634145
1553-Methylglutaconic aciduria (HP:0003535)1.83175384
156Decreased electroretinogram (ERG) amplitude (HP:0000654)1.83034353
157Facial diplegia (HP:0001349)1.82664718
158Gait imbalance (HP:0002141)1.81981338
159Intestinal atresia (HP:0011100)1.80545490
160Abnormality of the calf musculature (HP:0001430)1.80278950
161Renal cortical cysts (HP:0000803)1.79462576
162Abnormality of transition element cation homeostasis (HP:0011030)1.77123859
163Mitochondrial inheritance (HP:0001427)1.76455666
164Decreased circulating renin level (HP:0003351)1.75347057
165Reduced antithrombin III activity (HP:0001976)1.75200013
166Exercise-induced myalgia (HP:0003738)1.74575001
167Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.73831853

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.15795397
2SIK14.27659527
3FGFR44.01598119
4ERN13.90466326
5OBSCN3.87397960
6INSRR3.56893337
7TAOK33.11128190
8BMPR1B2.98215544
9ERBB42.63847040
10FLT32.43066269
11MAP4K22.25388379
12ADRBK22.24030395
13NEK92.20452567
14MST1R1.95316477
15PHKG11.94941552
16PHKG21.94941552
17PKN21.90749619
18MAP2K41.85322054
19PIK3CG1.84377352
20MAPK111.83181841
21TRIB31.80295035
22ZAK1.61184019
23LATS11.53889709
24TYK21.45963583
25TXK1.38105303
26MUSK1.36876019
27PINK11.36360120
28BRSK21.35454698
29ABL21.33142295
30STK391.29889905
31MAP3K41.29499970
32AKT31.28064206
33MAP3K71.27686204
34MAP3K141.25937706
35IRAK31.24980605
36OXSR11.23239779
37WNK31.22944215
38MST41.21831581
39STK38L1.21272136
40CASK1.20603991
41PTK61.19571020
42MAPK151.18576304
43TNIK1.12784264
44NTRK31.10477131
45JAK21.09826173
46PRKAA21.09470820
47DAPK21.09351640
48MAPK131.08642599
49MKNK21.07490160
50TBK11.05988725
51NLK1.05411543
52EIF2AK31.04865172
53WNK41.02845224
54TGFBR20.99897883
55TIE10.98761135
56FER0.98482982
57KDR0.95854634
58PRKCE0.94738533
59MET0.93692698
60ERBB30.93033079
61JAK10.91973133
62STK30.89498113
63FRK0.88917044
64MAPK40.87496491
65MAP3K130.82989095
66VRK10.82239504
67TRPM70.81921211
68PNCK0.80632452
69MAP2K30.79504473
70TNK20.79453770
71DYRK1B0.77898127
72FGFR20.77558476
73EPHB10.77192170
74MAPKAPK30.75765762
75PRKCZ0.75686901
76ADRBK10.74075098
77MAPK120.73539307
78IRAK10.72733489
79PRKACG0.72310804
80EPHA30.70538665
81SGK2230.70486196
82SGK4940.70486196
83GRK60.70452701
84ERBB20.69490891
85TEC0.68980914
86PTK2B0.68759510
87CAMK2G0.68742383
88CSF1R0.67451349
89PIK3CA0.65808333
90IRAK20.61084103
91MAP2K60.60229131
92PRKAA10.58801438
93GSK3A0.58376951
94PLK20.58345329
95MAP3K30.57078872
96IKBKE0.56166103
97WEE10.56010275
98PRKG10.55751434
99CSK0.55693929
100CAMK1D0.55032899
101STK160.54983362
102CDK190.54844291
103CSNK1G10.53767501
104PDK20.53161770
105PDPK10.52837032
106SGK30.52516344
107MAPK70.52481520
108PBK0.52359706
109CAMK2A0.51951334
110CDK60.51799088
111CAMKK20.51132719
112SGK20.50378435
113PDK30.49853177
114PDK40.49853177
115CSNK1A1L0.49671157
116BLK0.48755372
117BCR0.47582236
118MAP2K10.46669907
119KIT0.45500612
120IGF1R0.45329696
121PRKCQ0.44200892
122FGFR30.44139223
123MAP3K110.43986102
124RIPK10.43193740
125CSNK1G20.42048053
126ICK0.41344104
127PKN10.40988843
128CSNK1A10.40841645
129PTK20.39548547
130PRKACB0.38863096
131CAMK10.37992774
132CSNK1G30.37806667
133PLK30.37801045
134GRK70.37747923
135CSNK1D0.35873803
136CAMK2D0.35781722
137PDK10.34946687
138TRIM280.33685303
139PRKCG0.33438007
140TLK10.32866057
141MYLK0.31999784
142GRK10.31897422
143MKNK10.31832858
144ROCK10.30287741
145PAK30.28890537
146ACVR1B0.28793419
147STK240.28742168
148NUAK10.26524223
149EPHA40.25628432
150CDK30.25517577
151NTRK10.24946542
152PRKCA0.24906911
153TGFBR10.24419754
154RET0.24295116
155MELK0.23802693
156SGK10.23320937
157CAMK40.22578399
158ABL10.21493940
159EGFR0.20504717
160PRKACA0.20434659

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.34682801
2Nitrogen metabolism_Homo sapiens_hsa009103.37834155
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.28539166
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.15655464
5Arginine biosynthesis_Homo sapiens_hsa002202.85500702
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.76047616
7Tryptophan metabolism_Homo sapiens_hsa003802.68220932
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.66650591
9Complement and coagulation cascades_Homo sapiens_hsa046102.60362901
10Fatty acid degradation_Homo sapiens_hsa000712.58274745
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.55205687
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.50602244
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.30488200
14Butanoate metabolism_Homo sapiens_hsa006502.23020571
15Peroxisome_Homo sapiens_hsa041462.20258923
16Propanoate metabolism_Homo sapiens_hsa006402.13553248
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.11875777
18Fatty acid metabolism_Homo sapiens_hsa012121.93061318
19Chemical carcinogenesis_Homo sapiens_hsa052041.92098531
20Histidine metabolism_Homo sapiens_hsa003401.89255082
21PPAR signaling pathway_Homo sapiens_hsa033201.88208706
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.86005433
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.84433745
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.79675933
25beta-Alanine metabolism_Homo sapiens_hsa004101.75654697
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.68806526
27Caffeine metabolism_Homo sapiens_hsa002321.67769617
28Staphylococcus aureus infection_Homo sapiens_hsa051501.64805880
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.64415549
30Retinol metabolism_Homo sapiens_hsa008301.62617163
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.61329620
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.59278207
33Selenocompound metabolism_Homo sapiens_hsa004501.55522422
34Phenylalanine metabolism_Homo sapiens_hsa003601.54454096
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51572933
36Sulfur metabolism_Homo sapiens_hsa009201.48066221
37Pyruvate metabolism_Homo sapiens_hsa006201.46747784
38Fatty acid elongation_Homo sapiens_hsa000621.45407556
39Bile secretion_Homo sapiens_hsa049761.42796919
40Steroid biosynthesis_Homo sapiens_hsa001001.40776433
41Tyrosine metabolism_Homo sapiens_hsa003501.40377880
42Folate biosynthesis_Homo sapiens_hsa007901.33686954
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.30758430
44Starch and sucrose metabolism_Homo sapiens_hsa005001.27007097
45Phototransduction_Homo sapiens_hsa047441.17428812
46Carbon metabolism_Homo sapiens_hsa012001.15950433
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.15866412
48ABC transporters_Homo sapiens_hsa020101.15528499
49Biosynthesis of amino acids_Homo sapiens_hsa012301.15315949
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.08795052
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.06721869
52Cyanoamino acid metabolism_Homo sapiens_hsa004601.05201634
53Fat digestion and absorption_Homo sapiens_hsa049751.03862169
54Sulfur relay system_Homo sapiens_hsa041221.01880608
55Arginine and proline metabolism_Homo sapiens_hsa003301.01677920
56Circadian rhythm_Homo sapiens_hsa047100.98684304
57Vitamin digestion and absorption_Homo sapiens_hsa049770.97490709
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.97297706
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96174960
60Protein export_Homo sapiens_hsa030600.94572107
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92899466
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92010606
63Oxidative phosphorylation_Homo sapiens_hsa001900.91628443
64Vitamin B6 metabolism_Homo sapiens_hsa007500.84704376
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82894481
66Glutathione metabolism_Homo sapiens_hsa004800.75717767
67Lysine degradation_Homo sapiens_hsa003100.75586549
68Glycerolipid metabolism_Homo sapiens_hsa005610.71454492
69One carbon pool by folate_Homo sapiens_hsa006700.71099084
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69584231
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67052040
72Homologous recombination_Homo sapiens_hsa034400.66908308
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66372827
74Olfactory transduction_Homo sapiens_hsa047400.63518464
75Fatty acid biosynthesis_Homo sapiens_hsa000610.61340457
76Basal transcription factors_Homo sapiens_hsa030220.57120656
77Parkinsons disease_Homo sapiens_hsa050120.55099596
78Pentose phosphate pathway_Homo sapiens_hsa000300.55024978
79Metabolic pathways_Homo sapiens_hsa011000.51858672
80Cardiac muscle contraction_Homo sapiens_hsa042600.47769129
81Serotonergic synapse_Homo sapiens_hsa047260.44024755
82Insulin secretion_Homo sapiens_hsa049110.43336366
83Mineral absorption_Homo sapiens_hsa049780.39169983
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.37408318
85Huntingtons disease_Homo sapiens_hsa050160.36602636
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35538458
87RNA polymerase_Homo sapiens_hsa030200.35523789
88Alzheimers disease_Homo sapiens_hsa050100.34043619
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33598392
90Prion diseases_Homo sapiens_hsa050200.32154314
91Fructose and mannose metabolism_Homo sapiens_hsa000510.31671536
92Nicotine addiction_Homo sapiens_hsa050330.31417582
93Taste transduction_Homo sapiens_hsa047420.31408901
94Sphingolipid metabolism_Homo sapiens_hsa006000.30260526
95Galactose metabolism_Homo sapiens_hsa000520.28219667
96Calcium signaling pathway_Homo sapiens_hsa040200.27125849
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26651302
98Non-homologous end-joining_Homo sapiens_hsa034500.26048213
99Fanconi anemia pathway_Homo sapiens_hsa034600.25050120
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23745890
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.22387699
102Insulin resistance_Homo sapiens_hsa049310.19085320
103Linoleic acid metabolism_Homo sapiens_hsa005910.16783426
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.11331513
105Glucagon signaling pathway_Homo sapiens_hsa049220.06793632
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.01296279
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.00043860
108Protein digestion and absorption_Homo sapiens_hsa04974-0.2347969
109Ether lipid metabolism_Homo sapiens_hsa00565-0.2139139
110Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2044955
111Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.2040042
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1880278
113Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1837244
114Other glycan degradation_Homo sapiens_hsa00511-0.1834244
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1810749
116Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1784048
117African trypanosomiasis_Homo sapiens_hsa05143-0.1536453
118Hepatitis C_Homo sapiens_hsa05160-0.1431717
119Lysosome_Homo sapiens_hsa04142-0.1418680
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1377717
121Insulin signaling pathway_Homo sapiens_hsa04910-0.1338792
122Renin-angiotensin system_Homo sapiens_hsa04614-0.1126305
123Regulation of autophagy_Homo sapiens_hsa04140-0.1105038
124Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0783601
125Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0763252
126Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0243578
127AMPK signaling pathway_Homo sapiens_hsa04152-0.0236213

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »