Rank | Gene Set | Z-score |
---|---|---|
1 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 7.43294861 |
2 | L-phenylalanine catabolic process (GO:0006559) | 7.43294861 |
3 | L-phenylalanine metabolic process (GO:0006558) | 7.13190471 |
4 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 7.13190471 |
5 | aromatic amino acid family catabolic process (GO:0009074) | 6.71744740 |
6 | exogenous drug catabolic process (GO:0042738) | 6.64865513 |
7 | epoxygenase P450 pathway (GO:0019373) | 6.55533886 |
8 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 6.49099870 |
9 | omega-hydroxylase P450 pathway (GO:0097267) | 6.30517141 |
10 | tryptophan catabolic process (GO:0006569) | 6.13222352 |
11 | indole-containing compound catabolic process (GO:0042436) | 6.13222352 |
12 | indolalkylamine catabolic process (GO:0046218) | 6.13222352 |
13 | kynurenine metabolic process (GO:0070189) | 5.93633906 |
14 | high-density lipoprotein particle remodeling (GO:0034375) | 5.91478645 |
15 | negative regulation of fibrinolysis (GO:0051918) | 5.89508476 |
16 | bile acid biosynthetic process (GO:0006699) | 5.77972723 |
17 | tryptophan metabolic process (GO:0006568) | 5.75514379 |
18 | regulation of fibrinolysis (GO:0051917) | 5.66177102 |
19 | urea cycle (GO:0000050) | 5.64838624 |
20 | urea metabolic process (GO:0019627) | 5.64838624 |
21 | regulation of plasminogen activation (GO:0010755) | 5.64064428 |
22 | glyoxylate metabolic process (GO:0046487) | 5.63702067 |
23 | regulation of protein activation cascade (GO:2000257) | 5.57863745 |
24 | complement activation, alternative pathway (GO:0006957) | 5.57708906 |
25 | protein carboxylation (GO:0018214) | 5.57332485 |
26 | peptidyl-glutamic acid carboxylation (GO:0017187) | 5.57332485 |
27 | regulation of humoral immune response (GO:0002920) | 5.52521047 |
28 | alpha-linolenic acid metabolic process (GO:0036109) | 5.35446663 |
29 | regulation of cholesterol esterification (GO:0010872) | 5.31776884 |
30 | intestinal cholesterol absorption (GO:0030299) | 5.30691347 |
31 | sulfur amino acid catabolic process (GO:0000098) | 5.20567522 |
32 | nitrogen cycle metabolic process (GO:0071941) | 5.18921195 |
33 | regulation of apoptotic cell clearance (GO:2000425) | 5.15408313 |
34 | cysteine metabolic process (GO:0006534) | 5.14093549 |
35 | regulation of complement activation (GO:0030449) | 5.13373939 |
36 | reverse cholesterol transport (GO:0043691) | 5.10628864 |
37 | serine family amino acid catabolic process (GO:0009071) | 5.05285848 |
38 | protein-lipid complex remodeling (GO:0034368) | 5.04757588 |
39 | macromolecular complex remodeling (GO:0034367) | 5.04757588 |
40 | plasma lipoprotein particle remodeling (GO:0034369) | 5.04757588 |
41 | bile acid metabolic process (GO:0008206) | 4.98814416 |
42 | regulation of triglyceride catabolic process (GO:0010896) | 4.97479552 |
43 | phospholipid efflux (GO:0033700) | 4.89771936 |
44 | aromatic amino acid family metabolic process (GO:0009072) | 4.87779059 |
45 | cytolysis (GO:0019835) | 4.87574087 |
46 | negative regulation of cholesterol transport (GO:0032375) | 4.80858542 |
47 | negative regulation of sterol transport (GO:0032372) | 4.80858542 |
48 | fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) | 4.77566898 |
49 | tyrosine metabolic process (GO:0006570) | 4.73571944 |
50 | negative regulation of hemostasis (GO:1900047) | 4.71999647 |
51 | negative regulation of blood coagulation (GO:0030195) | 4.71999647 |
52 | triglyceride homeostasis (GO:0070328) | 4.62827717 |
53 | acylglycerol homeostasis (GO:0055090) | 4.62827717 |
54 | homocysteine metabolic process (GO:0050667) | 4.61952677 |
55 | drug metabolic process (GO:0017144) | 4.58170469 |
56 | negative regulation of complement activation (GO:0045916) | 4.55156295 |
57 | alpha-amino acid catabolic process (GO:1901606) | 4.54194610 |
58 | plasma lipoprotein particle clearance (GO:0034381) | 4.51037041 |
59 | amino-acid betaine metabolic process (GO:0006577) | 4.48789017 |
60 | cholesterol efflux (GO:0033344) | 4.45159269 |
61 | lysine catabolic process (GO:0006554) | 4.37272738 |
62 | lysine metabolic process (GO:0006553) | 4.37272738 |
63 | killing of cells in other organism involved in symbiotic interaction (GO:0051883) | 4.35206277 |
64 | disruption of cells of other organism involved in symbiotic interaction (GO:0051818) | 4.35206277 |
65 | positive regulation of blood coagulation (GO:0030194) | 4.34029457 |
66 | positive regulation of hemostasis (GO:1900048) | 4.34029457 |
67 | indolalkylamine metabolic process (GO:0006586) | 4.33324721 |
68 | negative regulation of coagulation (GO:0050819) | 4.31917419 |
69 | cellular ketone body metabolic process (GO:0046950) | 4.27825563 |
70 | negative regulation of wound healing (GO:0061045) | 4.27692333 |
71 | bile acid and bile salt transport (GO:0015721) | 4.27506835 |
72 | cellular biogenic amine catabolic process (GO:0042402) | 4.26893520 |
73 | amine catabolic process (GO:0009310) | 4.26893520 |
74 | acute-phase response (GO:0006953) | 4.24035017 |
75 | glycine metabolic process (GO:0006544) | 4.23598244 |
76 | coenzyme catabolic process (GO:0009109) | 4.22190731 |
77 | plasma lipoprotein particle assembly (GO:0034377) | 4.20592333 |
78 | fibrinolysis (GO:0042730) | 4.20208824 |
79 | imidazole-containing compound metabolic process (GO:0052803) | 4.17190473 |
80 | ethanol metabolic process (GO:0006067) | 4.16664947 |
81 | oxidative demethylation (GO:0070989) | 4.16636787 |
82 | cellular amino acid catabolic process (GO:0009063) | 4.16376103 |
83 | benzene-containing compound metabolic process (GO:0042537) | 4.15334895 |
84 | low-density lipoprotein particle remodeling (GO:0034374) | 4.10388416 |
85 | cellular glucuronidation (GO:0052695) | 4.09130323 |
86 | acute inflammatory response (GO:0002526) | 4.09055096 |
87 | glutamate metabolic process (GO:0006536) | 4.07810116 |
88 | blood coagulation, intrinsic pathway (GO:0007597) | 4.04274046 |
89 | serine family amino acid metabolic process (GO:0009069) | 4.01210718 |
90 | negative regulation of lipase activity (GO:0060192) | 4.00791456 |
91 | arginine metabolic process (GO:0006525) | 4.00272827 |
92 | positive regulation of coagulation (GO:0050820) | 3.97028146 |
93 | heme transport (GO:0015886) | 3.96719776 |
94 | cellular modified amino acid catabolic process (GO:0042219) | 3.96071642 |
95 | very-low-density lipoprotein particle assembly (GO:0034379) | 3.94223309 |
96 | opsonization (GO:0008228) | 3.93800092 |
97 | protein activation cascade (GO:0072376) | 3.91251568 |
98 | complement activation, classical pathway (GO:0006958) | 3.90415851 |
99 | positive regulation of triglyceride lipase activity (GO:0061365) | 3.90414102 |
100 | positive regulation of lipoprotein lipase activity (GO:0051006) | 3.90414102 |
101 | positive regulation of fatty acid biosynthetic process (GO:0045723) | 3.88687314 |
102 | aldehyde catabolic process (GO:0046185) | 3.88352416 |
103 | drug catabolic process (GO:0042737) | 3.87659987 |
104 | complement activation (GO:0006956) | 3.87277755 |
105 | dicarboxylic acid biosynthetic process (GO:0043650) | 3.85943274 |
106 | serine family amino acid biosynthetic process (GO:0009070) | 3.85217775 |
107 | negative regulation of protein activation cascade (GO:2000258) | 3.83467317 |
108 | positive regulation of lipid catabolic process (GO:0050996) | 3.83419830 |
109 | plasma lipoprotein particle organization (GO:0071827) | 3.81913104 |
110 | cofactor catabolic process (GO:0051187) | 3.78687683 |
111 | regulation of acute inflammatory response (GO:0002673) | 3.78678873 |
112 | ethanol oxidation (GO:0006069) | 3.78379338 |
113 | protein-lipid complex assembly (GO:0065005) | 3.74320121 |
114 | cholesterol homeostasis (GO:0042632) | 3.71431199 |
115 | positive regulation of heterotypic cell-cell adhesion (GO:0034116) | 3.69806996 |
116 | ketone body metabolic process (GO:1902224) | 3.69572809 |
117 | phospholipid homeostasis (GO:0055091) | 3.67434884 |
118 | sterol homeostasis (GO:0055092) | 3.65224232 |
119 | regulation of bile acid biosynthetic process (GO:0070857) | 3.64628841 |
120 | carboxylic acid catabolic process (GO:0046395) | 3.64115769 |
121 | organic acid catabolic process (GO:0016054) | 3.64115769 |
122 | glucuronate metabolic process (GO:0019585) | 3.62714021 |
123 | uronic acid metabolic process (GO:0006063) | 3.62714021 |
124 | phenylpropanoid metabolic process (GO:0009698) | 3.60992206 |
125 | protein-lipid complex subunit organization (GO:0071825) | 3.57540802 |
126 | negative regulation of humoral immune response (GO:0002921) | 3.56802054 |
127 | flavonoid metabolic process (GO:0009812) | 3.49874260 |
128 | lipoprotein metabolic process (GO:0042157) | 3.43407168 |
129 | doxorubicin metabolic process (GO:0044598) | 3.43126133 |
130 | daunorubicin metabolic process (GO:0044597) | 3.43126133 |
131 | polyketide metabolic process (GO:0030638) | 3.43126133 |
132 | cholesterol transport (GO:0030301) | 3.32360958 |
Rank | Gene Set | Z-score |
---|---|---|
1 | * RXR_22158963_ChIP-Seq_LIVER_Mouse | 8.28350790 |
2 | * EGR1_23403033_ChIP-Seq_LIVER_Mouse | 7.10959180 |
3 | * PPARA_22158963_ChIP-Seq_LIVER_Mouse | 7.08726091 |
4 | * LXR_22158963_ChIP-Seq_LIVER_Mouse | 6.41972486 |
5 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 5.40346870 |
6 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 5.29858815 |
7 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 4.85796692 |
8 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 4.24891679 |
9 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 4.09990861 |
10 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 2.03994908 |
11 | * ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 11.9489419 |
12 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.97125473 |
13 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.89268292 |
14 | * FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.59041401 |
15 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.53870256 |
16 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.50032070 |
17 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.45656779 |
18 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.43998006 |
19 | GATA1_22025678_ChIP-Seq_K562_Human | 1.40773287 |
20 | * HNF4A_19822575_ChIP-Seq_HepG2_Human | 1.39372738 |
21 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.31410603 |
22 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.29433257 |
23 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 1.25838996 |
24 | RXRA_24833708_ChIP-Seq_LIVER_Mouse | 1.18842008 |
25 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.15183839 |
26 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.10799395 |
27 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.09713955 |
28 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.09204874 |
29 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.08577370 |
30 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.02287470 |
31 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.98948234 |
32 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.97820747 |
33 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 0.97172324 |
34 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.96581349 |
35 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 0.91980712 |
36 | * CDX2_20551321_ChIP-Seq_CACO-2_Human | 0.89178921 |
37 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 0.85606841 |
38 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.83629556 |
39 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 0.83384939 |
40 | GATA4_25053715_ChIP-Seq_YYC3_Human | 0.80891483 |
41 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.79810812 |
42 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 0.79707526 |
43 | AR_21909140_ChIP-Seq_LNCAP_Human | 0.79458050 |
44 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 0.78020787 |
45 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 0.75215013 |
46 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.74755237 |
47 | RARA_24833708_ChIP-Seq_LIVER_Mouse | 0.73115619 |
48 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 0.72215456 |
49 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.71974239 |
50 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 0.71932615 |
51 | AR_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.71858373 |
52 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 0.68714669 |
53 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 0.68273855 |
54 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.67678419 |
55 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 0.66438732 |
56 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 0.66187952 |
57 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.65997915 |
58 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.65997915 |
59 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 0.65389985 |
60 | SMAD1_18555785_Chip-Seq_ESCs_Mouse | 0.64858168 |
61 | POU5F1_16518401_ChIP-PET_MESCs_Mouse | 0.64768332 |
62 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 0.64078175 |
63 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.63270963 |
64 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 0.62429526 |
65 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.61686495 |
66 | RARB_24833708_ChIP-Seq_LIVER_Mouse | 0.60836574 |
67 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 0.58917608 |
68 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.57528920 |
69 | * RAD21_21589869_ChIP-Seq_MESCs_Mouse | 0.57490307 |
70 | GATA3_20176728_ChIP-ChIP_TSCs_Mouse | 0.57274137 |
71 | AR_20517297_ChIP-Seq_VCAP_Human | 0.57192591 |
72 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 0.57173413 |
73 | ESRRB_18555785_Chip-Seq_ESCs_Mouse | 0.56861863 |
74 | FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.56593989 |
75 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.56459625 |
76 | RUNX1_27457419_Chip-Seq_LIVER_Mouse | 0.55907804 |
77 | OCT4_18555785_Chip-Seq_ESCs_Mouse | 0.55143053 |
78 | SOX2_21211035_ChIP-Seq_LN229_Human | 0.55090090 |
79 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.54976800 |
80 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 0.54234100 |
81 | FOXA1_25552417_ChIP-Seq_VCAP_Human | 0.53965841 |
82 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 0.53460509 |
83 | * CEBPB_22108803_ChIP-Seq_LS180_Human | 0.53181876 |
84 | FOXA1_26743006_Chip-Seq_LNCaP-abl_Human | 0.51846667 |
85 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 0.51804683 |
86 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.51774826 |
87 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.51368782 |
88 | PU1_27457419_Chip-Seq_LIVER_Mouse | 0.50768994 |
89 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.50683696 |
90 | * PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.50621766 |
91 | RAC3_21632823_ChIP-Seq_H3396_Human | 0.49737943 |
92 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 0.49165407 |
93 | ESET_19884257_ChIP-Seq_ESCs_Mouse | 0.49152413 |
94 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 0.48521075 |
95 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.48275634 |
96 | CBP_21632823_ChIP-Seq_H3396_Human | 0.47976691 |
97 | ZFX_18555785_Chip-Seq_ESCs_Mouse | 0.47660797 |
98 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 0.47643778 |
99 | STAT1_17558387_ChIP-Seq_HELA_Human | 0.47391941 |
100 | KLF4_18555785_Chip-Seq_ESCs_Mouse | 0.47135580 |
101 | MYC_19915707_ChIP-ChIP_AK7_Human | 0.46937488 |
102 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.46588172 |
103 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.46377690 |
104 | TP53_18474530_ChIP-ChIP_U2OS_Human | 0.46262121 |
105 | P53_21459846_ChIP-Seq_SAOS-2_Human | 0.46014212 |
106 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.45619229 |
107 | SOX11_22085726_ChIP-Seq_ESNs_Mouse | 0.45079748 |
108 | GATA3_24758297_ChIP-Seq_MCF-7_Human | 0.44792916 |
109 | NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse | 0.44678464 |
110 | * PPARG_20887899_ChIP-Seq_3T3-L1_Mouse | 0.44632923 |
111 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.44110434 |
112 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.44025582 |
113 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.43374624 |
114 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.42800043 |
115 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 0.42430095 |
116 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.41256695 |
117 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.41110031 |
118 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 0.40533428 |
119 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.40521030 |
120 | TAF2_19829295_ChIP-Seq_ESCs_Human | 0.39074445 |
121 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.39029838 |
122 | SOX2_20726797_ChIP-Seq_SW620_Human | 0.38894140 |
123 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.38731195 |
124 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.38623417 |
125 | STAT3_19079543_ChIP-ChIP_MESCs_Mouse | 0.38622226 |
126 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 0.38428085 |
127 | GATA6_25053715_ChIP-Seq_YYC3_Human | 0.38164597 |
128 | MYC_27129775_Chip-Seq_CORNEA_Mouse | 0.37580333 |
129 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.36969778 |
130 | GATA2_19941826_ChIP-Seq_K562_Human | 0.36656369 |
131 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 0.36373394 |
132 | SPI1_26923725_Chip-Seq_HPCs_Mouse | 0.36337752 |
133 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.35701096 |
134 | * CDX2_22108803_ChIP-Seq_LS180_Human | 0.35248282 |
135 | NCOR_22424771_ChIP-Seq_293T_Human | 0.35116136 |
136 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 0.34656864 |
137 | LUZP1_20508642_ChIP-Seq_ESCs_Mouse | 0.34521834 |
138 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.34229968 |
139 | GATA1_19941826_ChIP-Seq_K562_Human | 0.33930748 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0002139_abnormal_hepatobiliary_system | 8.34199567 |
2 | MP0005360_urolithiasis | 7.42204440 |
3 | MP0005085_abnormal_gallbladder_physiolo | 6.37949975 |
4 | MP0005365_abnormal_bile_salt | 6.20123358 |
5 | MP0008875_abnormal_xenobiotic_pharmacok | 5.06864557 |
6 | MP0003806_abnormal_nucleotide_metabolis | 4.09500380 |
7 | MP0003252_abnormal_bile_duct | 3.80653462 |
8 | MP0010329_abnormal_lipoprotein_level | 3.59675803 |
9 | MP0009840_abnormal_foam_cell | 3.34427182 |
10 | MP0005083_abnormal_biliary_tract | 3.04516975 |
11 | MP0003195_calcinosis | 2.83446319 |
12 | MP0005332_abnormal_amino_acid | 2.76655030 |
13 | MP0003191_abnormal_cellular_cholesterol | 2.64667853 |
14 | MP0001666_abnormal_nutrient_absorption | 2.56957365 |
15 | MP0000609_abnormal_liver_physiology | 2.15743985 |
16 | MP0004019_abnormal_vitamin_homeostasis | 2.10349908 |
17 | MP0002118_abnormal_lipid_homeostasis | 2.07727270 |
18 | MP0002138_abnormal_hepatobiliary_system | 2.02525579 |
19 | MP0003868_abnormal_feces_composition | 1.87521966 |
20 | MP0005319_abnormal_enzyme/_coenzyme | 1.81511206 |
21 | MP0003122_maternal_imprinting | 1.78343261 |
22 | MP0001764_abnormal_homeostasis | 1.69983100 |
23 | MP0009697_abnormal_copulation | 1.66683137 |
24 | MP0005584_abnormal_enzyme/coenzyme_acti | 1.53598013 |
25 | MP0005451_abnormal_body_composition | 1.44153572 |
26 | MP0003011_delayed_dark_adaptation | 1.42228164 |
27 | MP0001915_intracranial_hemorrhage | 1.41516441 |
28 | MP0005647_abnormal_sex_gland | 1.29332150 |
29 | MP0003656_abnormal_erythrocyte_physiolo | 1.28038833 |
30 | MP0003186_abnormal_redox_activity | 1.27579795 |
31 | MP0009643_abnormal_urine_homeostasis | 1.27062052 |
32 | MP0009764_decreased_sensitivity_to | 1.24255993 |
33 | MP0000598_abnormal_liver_morphology | 1.15925345 |
34 | MP0000604_amyloidosis | 1.15700572 |
35 | MP0009763_increased_sensitivity_to | 1.08995083 |
36 | MP0003705_abnormal_hypodermis_morpholog | 1.05545307 |
37 | MP0005636_abnormal_mineral_homeostasis | 1.03140870 |
38 | MP0002089_abnormal_postnatal_growth/wei | 1.02478365 |
39 | MP0005058_abnormal_lysosome_morphology | 1.01752674 |
40 | MP0002254_reproductive_system_inflammat | 1.01466217 |
41 | MP0000566_synostosis | 1.00954378 |
42 | MP0010368_abnormal_lymphatic_system | 1.00273866 |
43 | MP0008469_abnormal_protein_level | 0.96184786 |
44 | MP0005670_abnormal_white_adipose | 0.90266663 |
45 | MP0009642_abnormal_blood_homeostasis | 0.90086345 |
46 | MP0009765_abnormal_xenobiotic_induced | 0.86303496 |
47 | MP0002876_abnormal_thyroid_physiology | 0.82649227 |
48 | MP0005408_hypopigmentation | 0.81802647 |
49 | MP0003123_paternal_imprinting | 0.79796825 |
50 | MP0005376_homeostasis/metabolism_phenot | 0.78937272 |
51 | MP0005220_abnormal_exocrine_pancreas | 0.78024534 |
52 | MP0005084_abnormal_gallbladder_morpholo | 0.77878093 |
53 | MP0002282_abnormal_trachea_morphology | 0.75498721 |
54 | MP0002078_abnormal_glucose_homeostasis | 0.74647062 |
55 | MP0006036_abnormal_mitochondrial_physio | 0.74177636 |
56 | MP0002971_abnormal_brown_adipose | 0.71835014 |
57 | MP0001661_extended_life_span | 0.70935318 |
58 | MP0003172_abnormal_lysosome_physiology | 0.70722107 |
59 | MP0003690_abnormal_glial_cell | 0.70617089 |
60 | MP0009053_abnormal_anal_canal | 0.70274710 |
61 | MP0005334_abnormal_fat_pad | 0.68952566 |
62 | MP0005464_abnormal_platelet_physiology | 0.67999227 |
63 | MP0001756_abnormal_urination | 0.63708900 |
64 | MP0004272_abnormal_basement_membrane | 0.63113608 |
65 | MP0003879_abnormal_hair_cell | 0.62938808 |
66 | MP0000639_abnormal_adrenal_gland | 0.62883142 |
67 | MP0005535_abnormal_body_temperature | 0.61667903 |
68 | MP0005167_abnormal_blood-brain_barrier | 0.58007295 |
69 | MP0004130_abnormal_muscle_cell | 0.57479229 |
70 | MP0005266_abnormal_metabolism | 0.56916383 |
71 | MP0005448_abnormal_energy_balance | 0.53476541 |
72 | MP0003329_amyloid_beta_deposits | 0.53422809 |
73 | MP0005395_other_phenotype | 0.52661812 |
74 | MP0005409_darkened_coat_color | 0.52500745 |
75 | MP0003436_decreased_susceptibility_to | 0.52053066 |
76 | MP0003724_increased_susceptibility_to | 0.51406926 |
77 | MP0002136_abnormal_kidney_physiology | 0.51047570 |
78 | MP0003638_abnormal_response/metabolism_ | 0.49569934 |
79 | MP0006035_abnormal_mitochondrial_morpho | 0.49487724 |
80 | MP0005187_abnormal_penis_morphology | 0.48243820 |
81 | MP0003718_maternal_effect | 0.45621365 |
82 | MP0008873_increased_physiological_sensi | 0.45042643 |
83 | MP0000920_abnormal_myelination | 0.44819670 |
84 | MP0002249_abnormal_larynx_morphology | 0.44488165 |
85 | MP0008874_decreased_physiological_sensi | 0.44393167 |
86 | MP0005166_decreased_susceptibility_to | 0.43361170 |
87 | MP0002132_abnormal_respiratory_system | 0.43138035 |
88 | MP0002928_abnormal_bile_duct | 0.42580837 |
89 | MP0004782_abnormal_surfactant_physiolog | 0.42272208 |
90 | MP0003632_abnormal_nervous_system | 0.42005821 |
91 | MP0003075_altered_response_to | 0.41834575 |
92 | MP0005248_abnormal_Harderian_gland | 0.41730492 |
93 | MP0003953_abnormal_hormone_level | 0.39747303 |
94 | MP0006054_spinal_hemorrhage | 0.39125454 |
95 | MP0000579_abnormal_nail_morphology | 0.38361959 |
96 | MP0002822_catalepsy | 0.38314830 |
97 | MP0002933_joint_inflammation | 0.35975056 |
98 | MP0009780_abnormal_chondrocyte_physiolo | 0.35571374 |
99 | MP0004883_abnormal_blood_vessel | 0.35178918 |
100 | MP0003633_abnormal_nervous_system | 0.34995563 |
101 | MP0000249_abnormal_blood_vessel | 0.34826619 |
102 | MP0002128_abnormal_blood_circulation | 0.34727580 |
103 | MP0005666_abnormal_adipose_tissue | 0.34685438 |
104 | MP0001845_abnormal_inflammatory_respons | 0.34188918 |
105 | MP0001881_abnormal_mammary_gland | 0.33721860 |
106 | MP0008872_abnormal_physiological_respon | 0.33515162 |
107 | MP0006082_CNS_inflammation | 0.33483768 |
108 | MP0001324_abnormal_eye_pigmentation | 0.32879313 |
109 | MP0009115_abnormal_fat_cell | 0.32103224 |
110 | MP0002168_other_aberrant_phenotype | 0.31190201 |
111 | MP0009384_cardiac_valve_regurgitation | 0.30791637 |
112 | MP0004381_abnormal_hair_follicle | 0.30781175 |
113 | MP0003631_nervous_system_phenotype | 0.30709344 |
114 | MP0000230_abnormal_systemic_arterial | 0.30646729 |
115 | MP0005164_abnormal_response_to | 0.30496902 |
116 | MP0003566_abnormal_cell_adhesion | 0.30314249 |
117 | MP0001243_abnormal_dermal_layer | 0.30124179 |
118 | MP0001853_heart_inflammation | 0.29552986 |
119 | MP0009785_altered_susceptibility_to | 0.28955078 |
120 | MP0005257_abnormal_intraocular_pressure | 0.28474189 |
121 | MP0009672_abnormal_birth_weight | 0.28293884 |
122 | MP0003943_abnormal_hepatobiliary_system | 0.27937436 |
123 | MP0002909_abnormal_adrenal_gland | 0.27615081 |
124 | MP0003183_abnormal_peptide_metabolism | 0.27597059 |
125 | MP0002837_dystrophic_cardiac_calcinosis | 0.27512967 |
126 | MP0002135_abnormal_kidney_morphology | 0.27289718 |
127 | MP0002970_abnormal_white_adipose | 0.27162122 |
128 | MP0000858_altered_metastatic_potential | 0.26959538 |
129 | MP0003878_abnormal_ear_physiology | 0.26899275 |
130 | MP0005377_hearing/vestibular/ear_phenot | 0.26899275 |
131 | MP0002796_impaired_skin_barrier | 0.26525348 |
132 | MP0005023_abnormal_wound_healing | 0.25922596 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Deep venous thrombosis (HP:0002625) | 7.54028537 |
2 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 7.27092214 |
3 | Intrahepatic cholestasis (HP:0001406) | 7.18939366 |
4 | Prolonged partial thromboplastin time (HP:0003645) | 6.95041894 |
5 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 6.72040802 |
6 | Hypobetalipoproteinemia (HP:0003563) | 6.39456995 |
7 | Xanthomatosis (HP:0000991) | 6.17262966 |
8 | Hyperlipoproteinemia (HP:0010980) | 5.67214040 |
9 | Complement deficiency (HP:0004431) | 5.63464511 |
10 | Joint hemorrhage (HP:0005261) | 5.11837992 |
11 | Abnormality of the common coagulation pathway (HP:0010990) | 4.97727795 |
12 | Hypolipoproteinemia (HP:0010981) | 4.85863590 |
13 | Hyperammonemia (HP:0001987) | 4.54886583 |
14 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 4.45424501 |
15 | Epidermoid cyst (HP:0200040) | 4.38720524 |
16 | Abnormality of methionine metabolism (HP:0010901) | 4.32705541 |
17 | Hypoalphalipoproteinemia (HP:0003233) | 4.31871187 |
18 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 4.28551896 |
19 | Hyperglycinemia (HP:0002154) | 4.28225919 |
20 | Ketosis (HP:0001946) | 4.16187166 |
21 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 4.14872114 |
22 | Abnormality of complement system (HP:0005339) | 4.11885005 |
23 | Fat malabsorption (HP:0002630) | 4.10797979 |
24 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 4.09255584 |
25 | Abnormality of the intrinsic pathway (HP:0010989) | 4.02352518 |
26 | Abnormality of pyrimidine metabolism (HP:0004353) | 3.95123876 |
27 | Hypoglycemic coma (HP:0001325) | 3.85423900 |
28 | Spontaneous abortion (HP:0005268) | 3.81079618 |
29 | Hyperglycinuria (HP:0003108) | 3.80943053 |
30 | Abnormality of serine family amino acid metabolism (HP:0010894) | 3.77533214 |
31 | Abnormality of glycine metabolism (HP:0010895) | 3.77533214 |
32 | Conjugated hyperbilirubinemia (HP:0002908) | 3.73825867 |
33 | Hypercholesterolemia (HP:0003124) | 3.62424335 |
34 | Hyperbilirubinemia (HP:0002904) | 3.28771173 |
35 | Abnormality of fatty-acid metabolism (HP:0004359) | 3.27414867 |
36 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 3.24907763 |
37 | Steatorrhea (HP:0002570) | 3.12831637 |
38 | Abnormality of nucleobase metabolism (HP:0010932) | 3.04265912 |
39 | Purpura (HP:0000979) | 3.01556999 |
40 | Abnormality of serum amino acid levels (HP:0003112) | 2.99856524 |
41 | Delayed CNS myelination (HP:0002188) | 2.95325810 |
42 | Ketoacidosis (HP:0001993) | 2.95220948 |
43 | Myocardial infarction (HP:0001658) | 2.94728730 |
44 | Hepatocellular carcinoma (HP:0001402) | 2.91704398 |
45 | Systemic lupus erythematosus (HP:0002725) | 2.88186969 |
46 | Glomerulonephritis (HP:0000099) | 2.87757312 |
47 | Hypochromic microcytic anemia (HP:0004840) | 2.87486966 |
48 | Amyloidosis (HP:0011034) | 2.72150690 |
49 | Gingival bleeding (HP:0000225) | 2.71787734 |
50 | Metabolic acidosis (HP:0001942) | 2.70212437 |
51 | Skin nodule (HP:0200036) | 2.66378151 |
52 | Vascular calcification (HP:0004934) | 2.64607510 |
53 | Abnormality of purine metabolism (HP:0004352) | 2.58836930 |
54 | Osteomalacia (HP:0002749) | 2.57684083 |
55 | Lethargy (HP:0001254) | 2.56934077 |
56 | Hypoglycemic seizures (HP:0002173) | 2.54948758 |
57 | Dicarboxylic aciduria (HP:0003215) | 2.45972802 |
58 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.45972802 |
59 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.44840759 |
60 | Acanthocytosis (HP:0001927) | 2.43596181 |
61 | Mitral stenosis (HP:0001718) | 2.41042410 |
62 | Cerebral edema (HP:0002181) | 2.39762899 |
63 | Menorrhagia (HP:0000132) | 2.38214598 |
64 | Spastic diplegia (HP:0001264) | 2.37879482 |
65 | Thrombophlebitis (HP:0004418) | 2.35823609 |
66 | Abnormal gallbladder morphology (HP:0012437) | 2.33925115 |
67 | Cardiovascular calcification (HP:0011915) | 2.33824715 |
68 | Irritability (HP:0000737) | 2.28799972 |
69 | Cholelithiasis (HP:0001081) | 2.27913473 |
70 | Abnormal tarsal ossification (HP:0008369) | 2.27286187 |
71 | Neonatal onset (HP:0003623) | 2.26430616 |
72 | Gout (HP:0001997) | 2.22226494 |
73 | Pulmonary embolism (HP:0002204) | 2.21973558 |
74 | Arthropathy (HP:0003040) | 2.20225502 |
75 | Esophageal varix (HP:0002040) | 2.18831717 |
76 | Cholecystitis (HP:0001082) | 2.17738794 |
77 | Abnormal gallbladder physiology (HP:0012438) | 2.17738794 |
78 | Pancreatitis (HP:0001733) | 2.16804350 |
79 | Malnutrition (HP:0004395) | 2.15647109 |
80 | Late onset (HP:0003584) | 2.14797598 |
81 | Sensorimotor neuropathy (HP:0007141) | 2.13612841 |
82 | Abnormality of iron homeostasis (HP:0011031) | 2.12268680 |
83 | Increased serum pyruvate (HP:0003542) | 2.11591483 |
84 | Abnormality of transition element cation homeostasis (HP:0011030) | 2.09862484 |
85 | Enlarged kidneys (HP:0000105) | 2.09418369 |
86 | Brushfield spots (HP:0001088) | 2.07723915 |
87 | Abnormal delivery (HP:0001787) | 2.06207742 |
88 | Hyperinsulinemic hypoglycemia (HP:0000825) | 2.04328059 |
89 | Vomiting (HP:0002013) | 2.04098070 |
90 | Generalized aminoaciduria (HP:0002909) | 2.03408041 |
91 | Abnormality of carpal bone ossification (HP:0006257) | 2.02100307 |
92 | Nephritis (HP:0000123) | 2.01977306 |
93 | Opisthotonus (HP:0002179) | 2.01897997 |
94 | Hemorrhage of the eye (HP:0011885) | 1.97064398 |
95 | Poikilocytosis (HP:0004447) | 1.96478317 |
96 | Epistaxis (HP:0000421) | 1.96444682 |
97 | Rickets (HP:0002748) | 1.92538936 |
98 | Hypophosphatemic rickets (HP:0004912) | 1.91315374 |
99 | Abnormality of the Achilles tendon (HP:0005109) | 1.91224456 |
100 | Abnormality of the gallbladder (HP:0005264) | 1.90904467 |
101 | Renal cortical cysts (HP:0000803) | 1.89054199 |
102 | Facial shape deformation (HP:0011334) | 1.88228214 |
103 | Potter facies (HP:0002009) | 1.88228214 |
104 | Abnormality of glycolysis (HP:0004366) | 1.87689721 |
105 | Elevated hepatic transaminases (HP:0002910) | 1.81051711 |
106 | Hydroxyprolinuria (HP:0003080) | 1.80913638 |
107 | Abnormality of proline metabolism (HP:0010907) | 1.80913638 |
108 | Increased serum ferritin (HP:0003281) | 1.80674264 |
109 | Reduced antithrombin III activity (HP:0001976) | 1.80375308 |
110 | Status epilepticus (HP:0002133) | 1.78818490 |
111 | Abnormal enzyme/coenzyme activity (HP:0012379) | 1.76763281 |
112 | Alkalosis (HP:0001948) | 1.75373166 |
113 | Fair hair (HP:0002286) | 1.74185367 |
114 | Joint swelling (HP:0001386) | 1.73949550 |
115 | Hyperglycemia (HP:0003074) | 1.73812577 |
116 | Abnormal cartilage morphology (HP:0002763) | 1.73221347 |
117 | Gangrene (HP:0100758) | 1.69617478 |
118 | Elevated alkaline phosphatase (HP:0003155) | 1.68174649 |
119 | Pancreatic islet-cell hyperplasia (HP:0004510) | 1.60425413 |
120 | Hyperphosphaturia (HP:0003109) | 1.59700193 |
121 | Flat acetabular roof (HP:0003180) | 1.57923454 |
122 | Abnormality of alkaline phosphatase activity (HP:0004379) | 1.57076238 |
123 | Bifid scrotum (HP:0000048) | 1.54475308 |
124 | Small epiphyses (HP:0010585) | 1.53424083 |
125 | Neoplasm of the liver (HP:0002896) | 1.50806181 |
126 | Abnormality of urine glucose concentration (HP:0011016) | 1.48871922 |
127 | Glycosuria (HP:0003076) | 1.48871922 |
128 | Widely patent fontanelles and sutures (HP:0004492) | 1.46526211 |
129 | Abnormal hand bone ossification (HP:0010660) | 1.46071795 |
130 | Vaginal fistula (HP:0004320) | 1.43229967 |
Rank | Gene Set | Z-score |
---|---|---|
1 | BCKDK | 7.10705145 |
2 | ERN1 | 5.07917111 |
3 | FGFR4 | 4.56895794 |
4 | SIK1 | 4.25189061 |
5 | TAOK3 | 3.60786151 |
6 | INSRR | 3.10688350 |
7 | ERBB4 | 2.86088560 |
8 | WNK4 | 2.55803175 |
9 | CDK12 | 2.37434409 |
10 | MAP2K4 | 2.17901321 |
11 | MST1R | 2.16385697 |
12 | PIK3CG | 2.02624132 |
13 | PDGFRA | 1.90712143 |
14 | LATS1 | 1.90531976 |
15 | DAPK2 | 1.84149843 |
16 | MAPK11 | 1.83559071 |
17 | TYK2 | 1.80651752 |
18 | FGFR1 | 1.75106258 |
19 | TYRO3 | 1.72896357 |
20 | PKN2 | 1.68257456 |
21 | FLT3 | 1.67695987 |
22 | FRK | 1.65940051 |
23 | PTK6 | 1.49960117 |
24 | NEK9 | 1.39803777 |
25 | TRIB3 | 1.35655754 |
26 | ABL2 | 1.34616201 |
27 | EIF2AK1 | 1.30841353 |
28 | JAK2 | 1.26704615 |
29 | EPHA3 | 1.22103766 |
30 | NTRK3 | 1.18816206 |
31 | MAP3K14 | 1.18377173 |
32 | MAP3K2 | 1.17780749 |
33 | KDR | 1.16817906 |
34 | PINK1 | 1.13413479 |
35 | FGFR2 | 1.12278339 |
36 | JAK1 | 1.11854726 |
37 | WNK1 | 1.09414958 |
38 | TBK1 | 1.08632941 |
39 | ERBB2 | 1.05284244 |
40 | EPHB1 | 1.02924535 |
41 | PRKAA2 | 1.01700368 |
42 | MAP3K7 | 1.01290081 |
43 | MAP2K3 | 0.96895358 |
44 | STK38L | 0.96375909 |
45 | AKT3 | 0.96283259 |
46 | SIK2 | 0.95102579 |
47 | EEF2K | 0.94944922 |
48 | MAPK4 | 0.91845519 |
49 | GRK6 | 0.89629679 |
50 | DDR2 | 0.88351598 |
51 | BRSK2 | 0.86590868 |
52 | CSNK1E | 0.86148833 |
53 | PRKCZ | 0.85739926 |
54 | MAPKAPK3 | 0.84807617 |
55 | MAP3K3 | 0.84163133 |
56 | IRAK3 | 0.81733775 |
57 | MET | 0.78524438 |
58 | TIE1 | 0.78121081 |
59 | MAPK12 | 0.77689921 |
60 | CAMK2G | 0.75314596 |
61 | MAPK15 | 0.75051076 |
62 | MAP3K11 | 0.73857187 |
63 | PRKACG | 0.73597458 |
64 | IKBKE | 0.70852592 |
65 | MAP2K6 | 0.66997674 |
66 | NEK1 | 0.66656141 |
67 | CSK | 0.65723378 |
68 | CDK7 | 0.65554174 |
69 | SGK1 | 0.65481876 |
70 | RPS6KB1 | 0.63056606 |
71 | MAPK7 | 0.62030195 |
72 | CDK6 | 0.61316255 |
73 | FGFR3 | 0.60889771 |
74 | SGK3 | 0.60621896 |
75 | LATS2 | 0.60615807 |
76 | CAMKK2 | 0.59797172 |
77 | DYRK1B | 0.58601461 |
78 | CDC42BPA | 0.58173149 |
79 | FER | 0.57876788 |
80 | GSK3A | 0.57827038 |
81 | PRKAA1 | 0.57314812 |
82 | GRK1 | 0.56974206 |
83 | PRKG1 | 0.56905643 |
84 | CSF1R | 0.55493670 |
85 | CAMK1D | 0.54630965 |
86 | SCYL2 | 0.54602779 |
87 | TGFBR2 | 0.54069336 |
88 | RIPK1 | 0.53405640 |
89 | BCR | 0.53274739 |
90 | SGK2 | 0.53248379 |
91 | PIK3CA | 0.52699425 |
92 | FGR | 0.51917735 |
93 | CSNK1D | 0.51792802 |
94 | BRSK1 | 0.50908150 |
95 | PRKCQ | 0.49677755 |
96 | STK39 | 0.48486944 |
97 | MAP3K10 | 0.47434567 |
98 | SRC | 0.46178701 |
99 | PDPK1 | 0.44988449 |
100 | PKN1 | 0.44840729 |
101 | IRAK1 | 0.44795954 |
102 | IGF1R | 0.43601960 |
103 | TAOK2 | 0.43133098 |
104 | PTK2 | 0.42895253 |
105 | RPS6KA3 | 0.42699078 |
106 | CSNK2A2 | 0.42523017 |
107 | KSR2 | 0.42172215 |
108 | CSNK2A1 | 0.40552895 |
109 | MAP2K1 | 0.40378781 |
110 | PRKCG | 0.40084723 |
111 | CSNK1G1 | 0.38825864 |
112 | MAP3K5 | 0.38200583 |
113 | PRKACA | 0.36852755 |
114 | EPHA4 | 0.35157340 |
115 | NUAK1 | 0.35153561 |
116 | ZAP70 | 0.35136493 |
117 | BRD4 | 0.33730328 |
118 | PRKCB | 0.33607492 |
119 | CAMK4 | 0.31989505 |
120 | MATK | 0.31791759 |
121 | EGFR | 0.31011101 |
122 | SGK223 | 0.30867929 |
123 | SGK494 | 0.30867929 |
124 | MTOR | 0.29125008 |
125 | MAP3K13 | 0.29012339 |
126 | EPHA2 | 0.27998250 |
127 | RET | 0.27345458 |
128 | PRKCA | 0.27159205 |
129 | PDK1 | 0.26348843 |
130 | CDK4 | 0.25835987 |
131 | ICK | 0.25792441 |
132 | MAP3K6 | 0.24573565 |
133 | JAK3 | 0.24462761 |
134 | IRAK2 | 0.23761122 |
135 | MAP3K1 | 0.23147914 |
136 | PBK | 0.23107950 |
137 | PRKACB | 0.20909035 |
138 | MAP2K2 | 0.20734610 |
139 | MAPK3 | 0.20104388 |
140 | NLK | 0.19736646 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 4.53117179 |
2 | Nitrogen metabolism_Homo sapiens_hsa00910 | 3.48892845 |
3 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 3.40326436 |
4 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 3.32527270 |
5 | Arginine biosynthesis_Homo sapiens_hsa00220 | 3.11715623 |
6 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 3.03002993 |
7 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 2.66444563 |
8 | Tryptophan metabolism_Homo sapiens_hsa00380 | 2.65412585 |
9 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 2.56596228 |
10 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 2.54070689 |
11 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.43180690 |
12 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.34570285 |
13 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 2.24831601 |
14 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 2.17749839 |
15 | Peroxisome_Homo sapiens_hsa04146 | 2.09342956 |
16 | Butanoate metabolism_Homo sapiens_hsa00650 | 2.07643196 |
17 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 2.00996424 |
18 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.98537871 |
19 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.96012381 |
20 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.90825032 |
21 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.89249425 |
22 | Histidine metabolism_Homo sapiens_hsa00340 | 1.89153454 |
23 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.87429727 |
24 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.77584602 |
25 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.75667956 |
26 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.73091909 |
27 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.70281308 |
28 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.70174583 |
29 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.66344949 |
30 | Retinol metabolism_Homo sapiens_hsa00830 | 1.65622509 |
31 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.58323912 |
32 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.57687242 |
33 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.55896873 |
34 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.55578666 |
35 | Bile secretion_Homo sapiens_hsa04976 | 1.46610518 |
36 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.45755887 |
37 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.42178269 |
38 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.39124024 |
39 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.34860455 |
40 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.28889095 |
41 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.27642101 |
42 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.26521810 |
43 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.24917291 |
44 | ABC transporters_Homo sapiens_hsa02010 | 1.22605358 |
45 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.21092000 |
46 | Fat digestion and absorption_Homo sapiens_hsa04975 | 1.19908720 |
47 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.17976682 |
48 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.07897874 |
49 | Carbon metabolism_Homo sapiens_hsa01200 | 1.07490123 |
50 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.04833044 |
51 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.01193697 |
52 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.97621379 |
53 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.96746626 |
54 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.96127612 |
55 | Sulfur relay system_Homo sapiens_hsa04122 | 0.95388091 |
56 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.90949672 |
57 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.86623757 |
58 | Lysine degradation_Homo sapiens_hsa00310 | 0.79202026 |
59 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.78505023 |
60 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.75460411 |
61 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.68088053 |
62 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.65260573 |
63 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.63366922 |
64 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.56876437 |
65 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.50219266 |
66 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.47221352 |
67 | Metabolic pathways_Homo sapiens_hsa01100 | 0.46410970 |
68 | Other glycan degradation_Homo sapiens_hsa00511 | 0.45655858 |
69 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.37092988 |
70 | Prion diseases_Homo sapiens_hsa05020 | 0.36268787 |
71 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.28126155 |
72 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.25644414 |
73 | Galactose metabolism_Homo sapiens_hsa00052 | 0.24954788 |
74 | Insulin resistance_Homo sapiens_hsa04931 | 0.21490111 |
75 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.21321808 |
76 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.20936699 |
77 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.15905855 |
78 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.15587753 |
79 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.13918479 |
80 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.07855179 |
81 | Mineral absorption_Homo sapiens_hsa04978 | 0.05691666 |
82 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.00544229 |
83 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | -0.2536214 |
84 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | -0.2310397 |
85 | Amoebiasis_Homo sapiens_hsa05146 | -0.2282363 |
86 | Bladder cancer_Homo sapiens_hsa05219 | -0.2177048 |
87 | Pertussis_Homo sapiens_hsa05133 | -0.2112718 |
88 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | -0.2012054 |
89 | Serotonergic synapse_Homo sapiens_hsa04726 | -0.1831046 |
90 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | -0.1768249 |
91 | Circadian rhythm_Homo sapiens_hsa04710 | -0.1751869 |
92 | Protein digestion and absorption_Homo sapiens_hsa04974 | -0.1585939 |
93 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | -0.1554397 |
94 | Renin-angiotensin system_Homo sapiens_hsa04614 | -0.1464817 |
95 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | -0.1421436 |
96 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | -0.1403636 |
97 | ECM-receptor interaction_Homo sapiens_hsa04512 | -0.1334012 |
98 | Hepatitis C_Homo sapiens_hsa05160 | -0.1313948 |
99 | Insulin signaling pathway_Homo sapiens_hsa04910 | -0.1306922 |
100 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | -0.1294775 |
101 | Regulation of autophagy_Homo sapiens_hsa04140 | -0.1291481 |
102 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | -0.1097620 |
103 | African trypanosomiasis_Homo sapiens_hsa05143 | -0.1091097 |
104 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | -0.1021755 |
105 | Sphingolipid metabolism_Homo sapiens_hsa00600 | -0.0959992 |
106 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | -0.0918414 |
107 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | -0.0498538 |
108 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | -0.0426812 |
109 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | -0.0157854 |