FGL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. This protein may play a role in physiologic functions at mucosal sites. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of B cell proliferation (GO:0030889)5.74630875
2regulation of chronic inflammatory response (GO:0002676)5.41340449
3detection of other organism (GO:0098543)5.27624306
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.10392339
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.10392339
6positive regulation of respiratory burst (GO:0060267)5.08572225
7microglial cell activation (GO:0001774)4.95921785
8antigen processing and presentation of endogenous antigen (GO:0019883)4.90756955
9regulation of tumor necrosis factor biosynthetic process (GO:0042534)4.89178511
10response to peptidoglycan (GO:0032494)4.76360834
11detection of bacterium (GO:0016045)4.75552618
12regulation of regulatory T cell differentiation (GO:0045589)4.71891173
13positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.70030431
14cellular extravasation (GO:0045123)4.66083847
15regulation of interferon-alpha production (GO:0032647)4.65210436
16regulation of gamma-delta T cell activation (GO:0046643)4.63754169
17negative regulation of nitric oxide biosynthetic process (GO:0045019)4.34951129
18positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.32180179
19response to host immune response (GO:0052572)4.30779405
20response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.30779405
21detection of biotic stimulus (GO:0009595)4.30098348
22macrophage activation (GO:0042116)4.23174511
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.15085874
24modulation of growth of symbiont involved in interaction with host (GO:0044144)4.12579892
25regulation of growth of symbiont in host (GO:0044126)4.12579892
26negative regulation of growth of symbiont in host (GO:0044130)4.12579892
27negative regulation of growth of symbiont involved in interaction with host (GO:0044146)4.12579892
28regulation of T cell tolerance induction (GO:0002664)4.09062654
29regulation of gamma-delta T cell differentiation (GO:0045586)4.08434654
30regulation of MHC class II biosynthetic process (GO:0045346)4.06737746
31negative regulation of lymphocyte mediated immunity (GO:0002707)4.04532345
32negative regulation of interleukin-12 production (GO:0032695)3.96937270
33negative regulation of T cell mediated immunity (GO:0002710)3.95914392
34response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.95555684
35response to host (GO:0075136)3.95555684
36response to host defenses (GO:0052200)3.95555684
37respiratory burst (GO:0045730)3.91492259
38positive regulation of mast cell activation (GO:0033005)3.89525469
39positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.87805643
40antigen processing and presentation via MHC class Ib (GO:0002475)3.81004091
41detection of molecule of bacterial origin (GO:0032490)3.78744827
42myeloid cell activation involved in immune response (GO:0002275)3.76401316
43neutrophil activation (GO:0042119)3.74390863
44neutrophil mediated immunity (GO:0002446)3.68904555
45regulation of mast cell degranulation (GO:0043304)3.55308326
46branching involved in labyrinthine layer morphogenesis (GO:0060670)3.54811178
47negative regulation of B cell activation (GO:0050869)3.54044798
48tolerance induction (GO:0002507)3.52960789
49negative regulation of leukocyte mediated immunity (GO:0002704)3.52128575
50response to type I interferon (GO:0034340)3.49983582
51macrophage activation involved in immune response (GO:0002281)3.48645891
52B cell receptor signaling pathway (GO:0050853)3.48638874
53cellular response to type I interferon (GO:0071357)3.47144263
54type I interferon signaling pathway (GO:0060337)3.47144263
55production of molecular mediator involved in inflammatory response (GO:0002532)3.43699838
56negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.42085974
57negative regulation of cell killing (GO:0031342)3.42085974
58growth hormone receptor signaling pathway (GO:0060396)3.41949388
59granulocyte activation (GO:0036230)3.39873141
60positive thymic T cell selection (GO:0045059)3.38903961
61regulation of mast cell activation (GO:0033003)3.37010259
62negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.36880959
63positive regulation of toll-like receptor signaling pathway (GO:0034123)3.36867444
64regulation of myeloid leukocyte mediated immunity (GO:0002886)3.36851005
65regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.35627616
66positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.33559620
67positive regulation of cellular amide metabolic process (GO:0034250)3.31522661
68cellular defense response (GO:0006968)3.31381330
69regulation of tolerance induction (GO:0002643)3.31335555
70positive regulation of mast cell activation involved in immune response (GO:0033008)3.30364131
71positive regulation of mast cell degranulation (GO:0043306)3.30364131
72myeloid leukocyte mediated immunity (GO:0002444)3.30129982
73regulation of mast cell activation involved in immune response (GO:0033006)3.29189588
74B cell mediated immunity (GO:0019724)3.27713360
75regulation of interleukin-12 biosynthetic process (GO:0045075)3.26857857
76positive regulation of interferon-alpha production (GO:0032727)3.26507296
77T-helper 1 type immune response (GO:0042088)3.26047390
78activated T cell proliferation (GO:0050798)3.25575808
79cellular response to interferon-alpha (GO:0035457)3.25129640
80regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.22756478
81positive regulation of lymphocyte apoptotic process (GO:0070230)3.22583098
82opsonization (GO:0008228)3.19474159
83regulation of B cell receptor signaling pathway (GO:0050855)3.19011353
84positive regulation of B cell differentiation (GO:0045579)3.18905983
85regulation of B cell differentiation (GO:0045577)3.16506496
86regulation of leukocyte degranulation (GO:0043300)3.15029777
87angiogenesis involved in wound healing (GO:0060055)3.12536978
88dendritic cell migration (GO:0036336)3.12039203
89negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.11364852
90regulation of cytokine secretion involved in immune response (GO:0002739)3.10884480
91T-helper cell differentiation (GO:0042093)3.10457824
92CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.10457824
93response to muramyl dipeptide (GO:0032495)3.07969242
94positive regulation of natural killer cell differentiation (GO:0032825)3.07195931
95regulation of B cell proliferation (GO:0030888)3.06240502
96JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.05883861
97positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.05388837
98negative regulation of cytokine production involved in immune response (GO:0002719)3.04209683
99positive T cell selection (GO:0043368)3.02213550
100leukocyte migration involved in inflammatory response (GO:0002523)3.00419743
101T cell migration (GO:0072678)2.97891139
102defense response to protozoan (GO:0042832)2.97438840
103interferon-gamma-mediated signaling pathway (GO:0060333)2.96023813
104lipopolysaccharide-mediated signaling pathway (GO:0031663)2.95993801
105leukocyte aggregation (GO:0070486)2.93862835
106dendritic cell chemotaxis (GO:0002407)2.93290597
107immunoglobulin mediated immune response (GO:0016064)2.92937259
108regulation of dendritic cell antigen processing and presentation (GO:0002604)2.92920144
109response to protozoan (GO:0001562)2.92432291
110T cell selection (GO:0045058)2.92341955
111myeloid dendritic cell differentiation (GO:0043011)2.92077105
112cellular response to growth hormone stimulus (GO:0071378)2.92029952
113regulation of isotype switching (GO:0045191)2.91527948
114regulation of alpha-beta T cell proliferation (GO:0046640)2.90224620
115response to interferon-alpha (GO:0035455)2.90076638
116positive regulation of alpha-beta T cell proliferation (GO:0046641)2.89786331
117positive regulation of gamma-delta T cell activation (GO:0046645)2.89241417
118negative regulation of type 2 immune response (GO:0002829)2.88596353
119myeloid leukocyte activation (GO:0002274)2.88179964
120negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.87946529
121response to inactivity (GO:0014854)2.87677787
122neutrophil activation involved in immune response (GO:0002283)2.87649096
123regulation of macrophage cytokine production (GO:0010935)2.87323119
124negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.86752118
125regulation of interleukin-12 production (GO:0032655)2.84416681
126positive regulation of macrophage activation (GO:0043032)2.81166757
127negative thymic T cell selection (GO:0045060)2.81109443
128positive regulation of tolerance induction (GO:0002645)2.80372527
129positive regulation of neutrophil migration (GO:1902624)2.78550418
130positive regulation of neutrophil chemotaxis (GO:0090023)2.78550418
131negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.75863251
132negative regulation of T-helper cell differentiation (GO:0045623)2.75863251
133regulation of isotype switching to IgG isotypes (GO:0048302)2.74420279
134regulation of interferon-beta biosynthetic process (GO:0045357)2.74209785
135positive regulation of chemokine biosynthetic process (GO:0045080)2.74184970
136natural killer cell mediated cytotoxicity (GO:0042267)2.73103143
137natural killer cell mediated immunity (GO:0002228)2.73103143
138lymphocyte costimulation (GO:0031294)2.72713032
139positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.72432711
140cellular response to interleukin-15 (GO:0071350)2.71833963
141detection of external biotic stimulus (GO:0098581)2.71543602
142regulation of inflammatory response to antigenic stimulus (GO:0002861)2.70736749
143regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.70346818
144T cell differentiation involved in immune response (GO:0002292)2.69525814
145alpha-beta T cell differentiation involved in immune response (GO:0002293)2.69525814
146alpha-beta T cell activation involved in immune response (GO:0002287)2.69525814
147regulation of respiratory burst (GO:0060263)2.69021315
148response to interleukin-15 (GO:0070672)2.67338484
149positive regulation by symbiont of host defense response (GO:0052509)2.65943225
150modulation by symbiont of host defense response (GO:0052031)2.65943225
151modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.65943225
152modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.65943225
153positive regulation by organism of defense response of other organism involved in symbiotic interact2.65943225
154modulation by symbiont of host immune response (GO:0052553)2.65943225
155Arp2/3 complex-mediated actin nucleation (GO:0034314)2.65386977
156interferon-gamma production (GO:0032609)2.65358391
157negative T cell selection (GO:0043383)2.65103391
158regulation of T-helper 1 cell differentiation (GO:0045625)2.64547682

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.89056273
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.37422774
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.86375598
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.40734503
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.33446662
6STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.51613338
7* IRF8_27001747_Chip-Seq_BMDM_Mouse3.43211423
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.39303126
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.12299186
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.04848163
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.03969619
12RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.95626984
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.88079344
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.86159953
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.79149852
16* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.77195850
17RUNX_20019798_ChIP-Seq_JUKART_Human2.52641666
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.41195731
19* MYB_26560356_Chip-Seq_TH2_Human2.29917055
20Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.26151737
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.13944030
22MAF_26560356_Chip-Seq_TH1_Human2.00740584
23GATA1_22025678_ChIP-Seq_K562_Human1.99305974
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.96491579
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.94482953
26BRD4_27068464_Chip-Seq_AML-cells_Mouse1.92156682
27* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.91827638
28TP63_17297297_ChIP-ChIP_HaCaT_Human1.81745005
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.76464832
30MYB_26560356_Chip-Seq_TH1_Human1.73011749
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.68560293
32GATA2_21666600_ChIP-Seq_HMVEC_Human1.63925257
33PU_27001747_Chip-Seq_BMDM_Mouse1.63239211
34TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.61959436
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.60326425
36CLOCK_20551151_ChIP-Seq_293T_Human1.54009014
37ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.52292860
38EGR1_19032775_ChIP-ChIP_M12_Human1.50434555
39GATA3_27048872_Chip-Seq_THYMUS_Human1.49891622
40VDR_24787735_ChIP-Seq_THP-1_Human1.49430802
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.49027014
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.48832437
43GATA1_19941827_ChIP-Seq_MEL_Mouse1.47747289
44SPI1_23547873_ChIP-Seq_NB4_Human1.46676134
45SPI1_23127762_ChIP-Seq_K562_Human1.45521991
46RUNX1_22412390_ChIP-Seq_EML_Mouse1.43655482
47SCL_19346495_ChIP-Seq_HPC-7_Human1.42285468
48VDR_21846776_ChIP-Seq_THP-1_Human1.40798350
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.38062590
50VDR_24763502_ChIP-Seq_THP-1_Human1.35970126
51UTX_26944678_Chip-Seq_JUKART_Human1.35304037
52CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.34771520
53FOXO3_23340844_ChIP-Seq_DLD1_Human1.34178081
54CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.32311862
55GATA3_26560356_Chip-Seq_TH2_Human1.29098448
56TCF7_22412390_ChIP-Seq_EML_Mouse1.24861400
57BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24535762
58LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24082707
59RARG_19884340_ChIP-ChIP_MEFs_Mouse1.23923541
60PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20202060
61SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19669994
62* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19631100
63PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19035403
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.18859896
65ESR1_21235772_ChIP-Seq_MCF-7_Human1.18083751
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16606334
67* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16576481
68MYC_22102868_ChIP-Seq_BL_Human1.16558988
69E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.16231319
70GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14762558
71GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09207755
72KDM2B_26808549_Chip-Seq_DND41_Human1.07077312
73SOX2_20726797_ChIP-Seq_SW620_Human1.07034157
74KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06203639
75NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.05194190
76KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04041212
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01937115
78GATA1_19941826_ChIP-Seq_K562_Human1.01930984
79SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00901239
80GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00876968
81MAF_26560356_Chip-Seq_TH2_Human1.00871702
82IKZF1_21737484_ChIP-ChIP_HCT116_Human0.99032239
83BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98340913
84THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98243274
85LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.98202127
86RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97835080
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.96917816
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.96668215
89CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.96065643
90PPAR_26484153_Chip-Seq_NCI-H1993_Human0.94554425
91KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93915705
92VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.93747629
93ESR2_21235772_ChIP-Seq_MCF-7_Human0.93592953
94* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92910306
95SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.91941618
96SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.91941618
97CJUN_26792858_Chip-Seq_BT549_Human0.91646417
98GATA2_19941826_ChIP-Seq_K562_Human0.91458144
99CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89814115
100VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.89315703
101FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.89060730
102KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87501657
103ELF1_17652178_ChIP-ChIP_JURKAT_Human0.86252226
104GATA1_19941827_ChIP-Seq_MEL86_Mouse0.85265796
105CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84126032
106* TBX20_22080862_ChIP-Seq_HEART_Mouse0.83802583
107* TBX20_22328084_ChIP-Seq_HEART_Mouse0.83802583
108PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83644088
109RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.83624561
110TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.83160671
111* SMRT_27268052_Chip-Seq_Bcells_Human0.82781718
112* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.82073428
113ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.81601553
114SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.80939491
115GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80854725
116JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80346955
117PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80333218
118KDM2B_26808549_Chip-Seq_JURKAT_Human0.77341096
119* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.75128441
120SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.75060283
121KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.72120745
122RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67940945
123SPI1_20517297_ChIP-Seq_HL60_Human0.59310243

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.77178892
2MP0001835_abnormal_antigen_presentation3.79176547
3MP0003300_gastrointestinal_ulcer3.56835681
4MP0004510_myositis3.23465284
5* MP0005671_abnormal_response_to2.96445332
6MP0006082_CNS_inflammation2.89756296
7MP0003436_decreased_susceptibility_to2.79838414
8MP0008438_abnormal_cutaneous_collagen2.79752276
9MP0001873_stomach_inflammation2.78341437
10MP0001790_abnormal_immune_system2.75484417
11MP0005387_immune_system_phenotype2.75484417
12MP0002148_abnormal_hypersensitivity_rea2.54931350
13MP0001853_heart_inflammation2.52219055
14MP0003724_increased_susceptibility_to2.51803411
15* MP0009785_altered_susceptibility_to2.47215334
16MP0005000_abnormal_immune_tolerance2.43702717
17MP0008260_abnormal_autophagy2.43330906
18MP0000685_abnormal_immune_system2.42501075
19MP0000569_abnormal_digit_pigmentation2.34524546
20* MP0005025_abnormal_response_to2.28800151
21MP0001800_abnormal_humoral_immune2.27533944
22MP0002254_reproductive_system_inflammat2.25514707
23MP0002419_abnormal_innate_immunity2.16127807
24MP0005310_abnormal_salivary_gland2.09883766
25MP0001533_abnormal_skeleton_physiology2.06989642
26MP0002452_abnormal_antigen_presenting2.05194667
27MP0002723_abnormal_immune_serum2.02608608
28MP0000343_altered_response_to2.00423032
29MP0003448_altered_tumor_morphology1.96506842
30MP0002933_joint_inflammation1.91638693
31MP0002166_altered_tumor_susceptibility1.88508442
32MP0005058_abnormal_lysosome_morphology1.85748188
33MP0001819_abnormal_immune_cell1.84822742
34MP0002420_abnormal_adaptive_immunity1.81660245
35MP0004947_skin_inflammation1.78537800
36MP0010155_abnormal_intestine_physiology1.77844949
37MP0001845_abnormal_inflammatory_respons1.70946817
38MP0003763_abnormal_thymus_physiology1.70023566
39MP0005451_abnormal_body_composition1.68599290
40MP0003183_abnormal_peptide_metabolism1.57540366
41MP0002132_abnormal_respiratory_system1.54573809
42MP0002405_respiratory_system_inflammati1.54080838
43MP0004381_abnormal_hair_follicle1.52083300
44MP0003690_abnormal_glial_cell1.47355804
45MP0000858_altered_metastatic_potential1.47291643
46MP0002998_abnormal_bone_remodeling1.45030917
47MP0005464_abnormal_platelet_physiology1.44033021
48MP0003075_altered_response_to1.41113819
49MP0003279_aneurysm1.38920845
50MP0003045_fibrosis1.38439415
51MP0002006_tumorigenesis1.37216843
52MP0000716_abnormal_immune_system1.36850080
53MP0001542_abnormal_bone_strength1.35015240
54MP0006054_spinal_hemorrhage1.34464281
55MP0008469_abnormal_protein_level1.33626303
56MP0003566_abnormal_cell_adhesion1.32761586
57MP0009333_abnormal_splenocyte_physiolog1.32341520
58MP0005167_abnormal_blood-brain_barrier1.31778790
59MP0002398_abnormal_bone_marrow1.30424987
60MP0005023_abnormal_wound_healing1.27216274
61MP0002277_abnormal_respiratory_mucosa1.26023875
62MP0009764_decreased_sensitivity_to1.23665050
63MP0000015_abnormal_ear_pigmentation1.23095921
64MP0005275_abnormal_skin_tensile1.21188567
65MP0009278_abnormal_bone_marrow1.20962382
66MP0000604_amyloidosis1.20651333
67MP0002396_abnormal_hematopoietic_system1.20303174
68MP0000465_gastrointestinal_hemorrhage1.18127801
69MP0000249_abnormal_blood_vessel1.14683101
70MP0001958_emphysema1.14058400
71MP0005164_abnormal_response_to1.11653478
72MP0001663_abnormal_digestive_system1.11246239
73MP0001881_abnormal_mammary_gland1.10731643
74MP0002837_dystrophic_cardiac_calcinosis1.10421453
75MP0001348_abnormal_lacrimal_gland1.08882323
76MP0005166_decreased_susceptibility_to1.07757043
77MP0004883_abnormal_blood_vessel1.06754920
78MP0002429_abnormal_blood_cell1.03569788
79MP0008004_abnormal_stomach_pH1.03477711
80MP0001545_abnormal_hematopoietic_system1.02654065
81MP0005397_hematopoietic_system_phenotyp1.02654065
82MP0005390_skeleton_phenotype1.01304222
83MP0002722_abnormal_immune_system1.00720579
84MP0005075_abnormal_melanosome_morpholog0.99664934
85MP0005076_abnormal_cell_differentiation0.95893377
86MP0004084_abnormal_cardiac_muscle0.95316734
87MP0005165_increased_susceptibility_to0.95027473
88MP0002877_abnormal_melanocyte_morpholog0.94505498
89MP0005174_abnormal_tail_pigmentation0.93950365
90MP0003795_abnormal_bone_structure0.92540671
91MP0000689_abnormal_spleen_morphology0.91869092
92MP0010352_gastrointestinal_tract_polyps0.91267380
93MP0010307_abnormal_tumor_latency0.90981209
94MP0003656_abnormal_erythrocyte_physiolo0.90122185
95MP0001851_eye_inflammation0.88512627
96MP0003191_abnormal_cellular_cholesterol0.88113094
97MP0000703_abnormal_thymus_morphology0.86621322
98MP0000490_abnormal_crypts_of0.85946304
99MP0003866_abnormal_defecation0.84660738
100MP0004808_abnormal_hematopoietic_stem0.82905211
101MP0004130_abnormal_muscle_cell0.81966130
102MP0009763_increased_sensitivity_to0.81000595
103MP0003453_abnormal_keratinocyte_physiol0.79973866
104MP0004484_altered_response_of0.78549298
105MP0003172_abnormal_lysosome_physiology0.77878143
106MP0003221_abnormal_cardiomyocyte_apopto0.76280061
107MP0008874_decreased_physiological_sensi0.75786735
108MP0002138_abnormal_hepatobiliary_system0.74750683
109MP0003787_abnormal_imprinting0.73886604
110MP0000627_abnormal_mammary_gland0.73510729
111MP0003091_abnormal_cell_migration0.73383410
112MP0008775_abnormal_heart_ventricle0.73078054
113MP0002332_abnormal_exercise_endurance0.72823312
114MP0001986_abnormal_taste_sensitivity0.72649428
115MP0005381_digestive/alimentary_phenotyp0.71384741
116MP0002009_preneoplasia0.71149798
117MP0000767_abnormal_smooth_muscle0.70258199
118MP0003828_pulmonary_edema0.69376408
119MP0002693_abnormal_pancreas_physiology0.68650269
120MP0002133_abnormal_respiratory_system0.66319050
121MP0005388_respiratory_system_phenotype0.66319050
122MP0000013_abnormal_adipose_tissue0.65061875
123MP0000920_abnormal_myelination0.64290695
124MP0009765_abnormal_xenobiotic_induced0.63585281
125MP0003329_amyloid_beta_deposits0.61064244
126MP0003806_abnormal_nucleotide_metabolis0.58045690
127MP0003252_abnormal_bile_duct0.54972150
128MP0009115_abnormal_fat_cell0.54547018

Predicted human phenotypes

RankGene SetZ-score
1Optic neuritis (HP:0100653)6.74570265
2Retrobulbar optic neuritis (HP:0100654)6.74570265
3Orchitis (HP:0100796)6.53885137
4Myositis (HP:0100614)5.95853213
5Eczematoid dermatitis (HP:0000976)4.67698635
6Keratoconjunctivitis sicca (HP:0001097)4.61867351
7Pulmonary infiltrates (HP:0002113)4.55480416
8Hemoptysis (HP:0002105)4.39124125
9Keratoconjunctivitis (HP:0001096)4.15560682
10Arterial thrombosis (HP:0004420)4.14270918
11Recurrent cutaneous fungal infections (HP:0011370)4.13163838
12Chronic mucocutaneous candidiasis (HP:0002728)4.13163838
13Vasculitis (HP:0002633)4.06133147
14Gangrene (HP:0100758)4.01828263
15Obstructive lung disease (HP:0006536)3.96326028
16Chronic obstructive pulmonary disease (HP:0006510)3.96326028
17Pulmonary embolism (HP:0002204)3.94611773
18T lymphocytopenia (HP:0005403)3.76611898
19Gastrointestinal infarctions (HP:0005244)3.72097171
20Chest pain (HP:0100749)3.66775500
21Abnormality of the prostate (HP:0008775)3.57529821
22Abnormal delayed hypersensitivity skin test (HP:0002963)3.56779582
23Systemic lupus erythematosus (HP:0002725)3.47740785
24Recurrent abscess formation (HP:0002722)3.45942570
25Abnormality of the pericardium (HP:0001697)3.40515498
26Autoimmune thrombocytopenia (HP:0001973)3.38836094
27Recurrent bacterial skin infections (HP:0005406)3.27955394
28Aortic dissection (HP:0002647)3.27847146
29Spondylolisthesis (HP:0003302)3.27416069
30Amyloidosis (HP:0011034)3.21715633
31Meningitis (HP:0001287)3.17679393
32Abnormality of macrophages (HP:0004311)3.17189413
33Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.13075043
34Recurrent bronchitis (HP:0002837)3.11420002
35Osteolytic defects of the phalanges of the hand (HP:0009771)3.11321915
36Osteolytic defects of the hand bones (HP:0009699)3.11321915
37Petechiae (HP:0000967)3.09842322
38Thrombophlebitis (HP:0004418)3.01374094
39Elevated erythrocyte sedimentation rate (HP:0003565)3.01138569
40Purpura (HP:0000979)2.95887686
41Abnormality of the pleura (HP:0002103)2.94943753
42Glomerulopathy (HP:0100820)2.92464560
43Gingival bleeding (HP:0000225)2.92374181
44Ureteral stenosis (HP:0000071)2.91939607
45Cellulitis (HP:0100658)2.86189573
46Ureteral obstruction (HP:0006000)2.84985745
47Encephalitis (HP:0002383)2.81258330
48Anorexia (HP:0002039)2.79314134
49Chronic otitis media (HP:0000389)2.79179970
50Recurrent gram-negative bacterial infections (HP:0005420)2.79068252
51Polyneuropathy (HP:0001271)2.77117641
52Prolonged bleeding time (HP:0003010)2.76105887
53Aortic aneurysm (HP:0004942)2.69213928
54Recurrent fungal infections (HP:0002841)2.66640263
55Spontaneous hematomas (HP:0007420)2.64356420
56Inflammation of the large intestine (HP:0002037)2.61651559
57Mediastinal lymphadenopathy (HP:0100721)2.57764242
58Cerebral aneurysm (HP:0004944)2.55328932
59Episodic fever (HP:0001954)2.52173492
60Nasal polyposis (HP:0100582)2.50041284
61Fatigue (HP:0012378)2.48987650
62Osteomyelitis (HP:0002754)2.48119862
63Gastrointestinal inflammation (HP:0004386)2.46127860
64Pustule (HP:0200039)2.45076731
65Cerebral ischemia (HP:0002637)2.44576656
66Abnormality of the nasal mucosa (HP:0000433)2.43816272
67Abnormality of the peritoneum (HP:0002585)2.43372802
68Persistence of primary teeth (HP:0006335)2.43199297
69Pancreatitis (HP:0001733)2.41204275
70Stomatitis (HP:0010280)2.40987876
71Myocardial infarction (HP:0001658)2.39268814
72Recurrent viral infections (HP:0004429)2.37507296
73Dysostosis multiplex (HP:0000943)2.35970444
74Colitis (HP:0002583)2.35071454
75Gingivitis (HP:0000230)2.34339890
76Vacuolated lymphocytes (HP:0001922)2.30435271
77Arterial tortuosity (HP:0005116)2.29971131
78Hematochezia (HP:0002573)2.28656772
79Absent frontal sinuses (HP:0002688)2.28483803
80Urinary glycosaminoglycan excretion (HP:0003541)2.25693625
81Mucopolysacchariduria (HP:0008155)2.25693625
82Increased IgM level (HP:0003496)2.25206449
83Epistaxis (HP:0000421)2.25190797
84Peritonitis (HP:0002586)2.24068231
85Panhypogammaglobulinemia (HP:0003139)2.23624156
86Cheilitis (HP:0100825)2.21301148
87Chronic sinusitis (HP:0011109)2.21080029
88Granulocytopenia (HP:0001913)2.20336162
89Increased cerebral lipofuscin (HP:0011813)2.20299113
90Abnormality of glycolipid metabolism (HP:0010969)2.12637958
91Abnormality of liposaccharide metabolism (HP:0010968)2.12637958
92Abnormality of glycosphingolipid metabolism (HP:0004343)2.12637958
93Viral hepatitis (HP:0006562)2.12098671
94Recurrent skin infections (HP:0001581)2.11739146
95Premature rupture of membranes (HP:0001788)2.11418997
96Amaurosis fugax (HP:0100576)2.11116039
97Abnormality of the endocardium (HP:0004306)2.09615514
98Eosinophilia (HP:0001880)2.08210560
99Vascular tortuosity (HP:0004948)2.08163610
100Sepsis (HP:0100806)2.07679699
101Vertigo (HP:0002321)2.06862506
102Hypochromic microcytic anemia (HP:0004840)2.06484052
103Interstitial pulmonary disease (HP:0006530)2.06340885
104Asymmetric septal hypertrophy (HP:0001670)2.05440408
105Loss of speech (HP:0002371)2.05174439
106Hypochromic anemia (HP:0001931)2.04519694
107Abnormality of polysaccharide metabolism (HP:0011012)2.04014530
108Abnormality of glycosaminoglycan metabolism (HP:0004371)2.04014530
109Abnormality of mucopolysaccharide metabolism (HP:0011020)2.04014530
110Skin ulcer (HP:0200042)2.03055819
111Paresthesia (HP:0003401)2.02705718
112Hypergammaglobulinemia (HP:0010702)2.00808372
113Restrictive lung disease (HP:0002091)2.00792462
114Acute hepatic failure (HP:0006554)2.00408818
115Periodontitis (HP:0000704)2.00006822
116Increased IgE level (HP:0003212)1.96761218
117Subacute progressive viral hepatitis (HP:0006572)1.95673325
118Abnormality of T cell number (HP:0011839)1.93338893
119Slow saccadic eye movements (HP:0000514)1.92892304
120Emphysema (HP:0002097)1.92717353
121Abnormality of T cell physiology (HP:0011840)1.91559415
122Premature loss of primary teeth (HP:0006323)1.91070744
123Keratitis (HP:0000491)1.90384465
124Skin rash (HP:0000988)1.90325745
125Leukocytosis (HP:0001974)1.89142611
126Autoimmune hemolytic anemia (HP:0001890)1.89132587
127Tetraparesis (HP:0002273)1.88672058
128Abnormality of T cells (HP:0002843)1.87861625
129Malnutrition (HP:0004395)1.87598483
130Polycythemia (HP:0001901)1.87594291
131Arthralgia (HP:0002829)1.86407877
132Glomerulonephritis (HP:0000099)1.85545287
133Porencephaly (HP:0002132)1.85503513
134Acne (HP:0001061)1.85235360
135Increased neuronal autofluorescent lipopigment (HP:0002074)1.85023498
136Urticaria (HP:0001025)1.83737598
137Recurrent pneumonia (HP:0006532)1.82203840
138Lymphopenia (HP:0001888)1.81960207
139Microcytic anemia (HP:0001935)1.80666441
140Disinhibition (HP:0000734)1.79371125

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK9.03540190
2TYK22.86544822
3JAK32.77141630
4JAK12.73932420
5TBK12.47724445
6MAP3K142.44078269
7TGFBR22.37418676
8TAOK32.28274320
9IKBKE2.19562506
10EPHB12.18581004
11MAP4K12.15740753
12FGFR42.12672010
13PRPF4B2.07483541
14ERN12.06567387
15IRAK42.02977340
16KIT1.90678761
17EPHA31.84601610
18ZAP701.78888890
19TTN1.72349298
20FGFR31.70418103
21MYLK1.66193598
22TRIB31.63956370
23JAK21.62622152
24BLK1.43612313
25YES11.42403243
26PBK1.41289122
27TNK21.41004195
28BMPR21.40069712
29ITK1.39392721
30IKBKB1.36441851
31IRAK31.35959853
32KSR21.34545429
33DMPK1.33596685
34CSK1.21177348
35TEC1.19403218
36IRAK11.15528365
37LCK1.15455284
38HCK1.15186361
39TAOK11.12445413
40SYK1.08516498
41PIM21.07180418
42RIPK11.05909810
43NEK91.05882080
44STK101.01650680
45BTK1.00106271
46CHUK0.98201617
47CAMKK20.97235252
48MAP3K110.96857643
49MAP3K60.94873229
50CDK190.87755183
51RIPK40.86090193
52MAP3K130.83784301
53MARK20.81136112
54TRPM70.80116258
55PIK3CG0.79024575
56LRRK20.78913315
57MAP3K100.77886555
58PTK60.74586323
59MAP2K30.74573830
60STK240.74025322
61SGK30.70533813
62MAP3K30.70132286
63PTK2B0.69875365
64SIK30.67891515
65PKN20.67478144
66BMX0.66746268
67MARK30.65808249
68FES0.64753746
69SGK20.64697935
70MAP2K40.64640093
71NLK0.63265953
72CDC42BPA0.62854628
73PIM10.62827733
74KSR10.62113511
75MAPK70.59712666
76KDR0.58923245
77WNK10.58029345
78RAF10.57491313
79CDK60.57267370
80MAPK120.56753486
81PDGFRA0.55864329
82STK110.54528892
83PRKCQ0.53165958
84STK40.51935450
85RPS6KA40.51502637
86CAMKK10.50246655
87MAP3K70.49141803
88TESK10.48031385
89FLT30.47803296
90LYN0.47774337
91MAPKAPK30.47667461
92ACVR1B0.47291438
93MAPKAPK20.47021806
94STK30.46599015
95MATK0.45946161
96ABL10.44811138
97PDPK10.44713729
98GRK70.43209983
99MST40.43087589
100GRK50.42787750
101IRAK20.42658765
102PDGFRB0.41823420
103CSF1R0.41551298
104PDK10.40613819
105HIPK20.38245644
106FYN0.38081312
107FGR0.37988568
108FRK0.37967051
109PRKCH0.37445878
110ALK0.37087048
111RET0.36678015
112ILK0.34744633
113MAP3K120.34446969
114MAPK110.34424491
115MAP3K50.34129405
116MAP3K10.33649660
117TAOK20.33524173
118MAPK40.33509730
119PRKD20.32902646
120MAP2K60.31972011
121RPS6KL10.31933509
122RPS6KC10.31933509
123EGFR0.31664521
124MAP3K20.31321640
125MOS0.30822227
126DAPK20.30270244
127NUAK10.29598135
128CAMK40.29116603
129GSK3A0.28016823
130IGF1R0.25438827
131LMTK20.25286027
132GRK60.24097557
133DAPK30.23321536
134PAK20.22027553
135DYRK1B0.21950869
136PTK20.21486343

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053304.86618677
2Autoimmune thyroid disease_Homo sapiens_hsa053204.79902340
3Asthma_Homo sapiens_hsa053103.48683100
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.17162050
5Leishmaniasis_Homo sapiens_hsa051402.99694258
6Staphylococcus aureus infection_Homo sapiens_hsa051502.77393241
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.76370118
8Graft-versus-host disease_Homo sapiens_hsa053322.16812368
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.09164945
10Osteoclast differentiation_Homo sapiens_hsa043802.00032179
11Pertussis_Homo sapiens_hsa051331.91253340
12Toxoplasmosis_Homo sapiens_hsa051451.86662894
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.86258141
14Malaria_Homo sapiens_hsa051441.84018241
15Measles_Homo sapiens_hsa051621.79109221
16Viral myocarditis_Homo sapiens_hsa054161.67708475
17T cell receptor signaling pathway_Homo sapiens_hsa046601.60339485
18Primary immunodeficiency_Homo sapiens_hsa053401.58760175
19Tuberculosis_Homo sapiens_hsa051521.56594173
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.55393254
21Jak-STAT signaling pathway_Homo sapiens_hsa046301.54932038
22Hematopoietic cell lineage_Homo sapiens_hsa046401.49565017
23Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.49180747
24Antigen processing and presentation_Homo sapiens_hsa046121.48160831
25Rheumatoid arthritis_Homo sapiens_hsa053231.41774114
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.38943128
27African trypanosomiasis_Homo sapiens_hsa051431.36524809
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.34277619
29TNF signaling pathway_Homo sapiens_hsa046681.30967359
30Influenza A_Homo sapiens_hsa051641.29427821
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.27074407
32Type I diabetes mellitus_Homo sapiens_hsa049401.24057660
33Chemokine signaling pathway_Homo sapiens_hsa040621.23228555
34Lysosome_Homo sapiens_hsa041421.19060880
35Amoebiasis_Homo sapiens_hsa051461.18285312
36Legionellosis_Homo sapiens_hsa051341.16257280
37Non-small cell lung cancer_Homo sapiens_hsa052231.14805638
38NOD-like receptor signaling pathway_Homo sapiens_hsa046211.13617149
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.10038632
40Salmonella infection_Homo sapiens_hsa051321.09035616
41Apoptosis_Homo sapiens_hsa042101.08291998
42B cell receptor signaling pathway_Homo sapiens_hsa046621.06997091
43Caffeine metabolism_Homo sapiens_hsa002321.03513229
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.00940273
45Other glycan degradation_Homo sapiens_hsa005110.99812725
46Herpes simplex infection_Homo sapiens_hsa051680.98412172
47Shigellosis_Homo sapiens_hsa051310.98013305
48Leukocyte transendothelial migration_Homo sapiens_hsa046700.95737456
49Hepatitis B_Homo sapiens_hsa051610.92505835
50Chronic myeloid leukemia_Homo sapiens_hsa052200.84191377
51Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83988204
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83316927
53Pancreatic cancer_Homo sapiens_hsa052120.83158027
54Platelet activation_Homo sapiens_hsa046110.81334085
55Phagosome_Homo sapiens_hsa041450.80192583
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78686507
57Prolactin signaling pathway_Homo sapiens_hsa049170.76639485
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75568731
59Hepatitis C_Homo sapiens_hsa051600.73245871
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71783498
61Small cell lung cancer_Homo sapiens_hsa052220.70216879
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69869107
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68509309
64Acute myeloid leukemia_Homo sapiens_hsa052210.66211064
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65558695
66Focal adhesion_Homo sapiens_hsa045100.64900658
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64606553
68GnRH signaling pathway_Homo sapiens_hsa049120.63763536
69Complement and coagulation cascades_Homo sapiens_hsa046100.61939407
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61551238
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.58502890
72Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58183175
73ECM-receptor interaction_Homo sapiens_hsa045120.57684644
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55206507
75Proteoglycans in cancer_Homo sapiens_hsa052050.55189600
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54479603
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54333707
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52880989
79Inositol phosphate metabolism_Homo sapiens_hsa005620.52279452
80Endometrial cancer_Homo sapiens_hsa052130.52163647
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.51577744
82Dilated cardiomyopathy_Homo sapiens_hsa054140.50402185
83Choline metabolism in cancer_Homo sapiens_hsa052310.49158570
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49083121
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49018816
86FoxO signaling pathway_Homo sapiens_hsa040680.47902805
87mTOR signaling pathway_Homo sapiens_hsa041500.47579227
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.45820226
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45098115
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44451861
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43337976
92VEGF signaling pathway_Homo sapiens_hsa043700.42243170
93Long-term potentiation_Homo sapiens_hsa047200.41607521
94Type II diabetes mellitus_Homo sapiens_hsa049300.41191218
95Insulin resistance_Homo sapiens_hsa049310.39849248
96Estrogen signaling pathway_Homo sapiens_hsa049150.39584053
97Renal cell carcinoma_Homo sapiens_hsa052110.38874933
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37277698
99HIF-1 signaling pathway_Homo sapiens_hsa040660.34837756
100Regulation of autophagy_Homo sapiens_hsa041400.34382151
101ErbB signaling pathway_Homo sapiens_hsa040120.34328327
102Viral carcinogenesis_Homo sapiens_hsa052030.32505773
103Rap1 signaling pathway_Homo sapiens_hsa040150.32350085
104Epstein-Barr virus infection_Homo sapiens_hsa051690.32334172
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.31499233
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.28358830
107Endocytosis_Homo sapiens_hsa041440.28286326
108Renin-angiotensin system_Homo sapiens_hsa046140.28208062
109Notch signaling pathway_Homo sapiens_hsa043300.28037057
110Prion diseases_Homo sapiens_hsa050200.28022466
111HTLV-I infection_Homo sapiens_hsa051660.27931002
112Dorso-ventral axis formation_Homo sapiens_hsa043200.26944935
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.26781847
114MicroRNAs in cancer_Homo sapiens_hsa052060.25070051
115Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.24399577
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.20319784
117MAPK signaling pathway_Homo sapiens_hsa040100.19909230
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.19433383
119Pancreatic secretion_Homo sapiens_hsa049720.19036186
120Pathways in cancer_Homo sapiens_hsa052000.17918594
121Protein digestion and absorption_Homo sapiens_hsa049740.17896088
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.16969669

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