ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.40648322
2	nuclear pore complex assembly (GO:0051292)	4.30313915
3	NADH metabolic process (GO:0006734)	4.18237049
4	mitotic chromosome condensation (GO:0007076)	4.16620792
5	* tricarboxylic acid cycle (GO:0006099)	4.09790346
6	formation of translation preinitiation complex (GO:0001731)	4.03992148
7	DNA unwinding involved in DNA replication (GO:0006268)	3.94525260
8	nucleobase-containing small molecule interconversion (GO:0015949)	3.94297475
9	DNA strand elongation involved in DNA replication (GO:0006271)	3.90826044
10	oxidative phosphorylation (GO:0006119)	3.87051766
11	regulation of translational fidelity (GO:0006450)	3.85550466
12	nuclear pore organization (GO:0006999)	3.80151994
13	DNA strand elongation (GO:0022616)	3.78415850
14	mitotic sister chromatid segregation (GO:0000070)	3.64976605
15	telomere maintenance via semi-conservative replication (GO:0032201)	3.56524488
16	ribosomal large subunit biogenesis (GO:0042273)	3.55220715
17	establishment of integrated proviral latency (GO:0075713)	3.54342022
18	ATP synthesis coupled proton transport (GO:0015986)	3.50709035
19	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.50709035
20	oxaloacetate metabolic process (GO:0006107)	3.49934226
21	ribosomal small subunit biogenesis (GO:0042274)	3.48657880
22	L-serine metabolic process (GO:0006563)	3.47934612
23	sister chromatid segregation (GO:0000819)	3.33613077
24	ribosome assembly (GO:0042255)	3.27311122
25	DNA replication checkpoint (GO:0000076)	3.24596796
26	mitotic metaphase plate congression (GO:0007080)	3.24319591
27	pore complex assembly (GO:0046931)	3.22213660
28	regulation of mitochondrial translation (GO:0070129)	3.20203966
29	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.18988400
30	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.16522240
31	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.13738512
32	purine nucleobase biosynthetic process (GO:0009113)	3.12782238
33	COPI coating of Golgi vesicle (GO:0048205)	3.12018757
34	Golgi transport vesicle coating (GO:0048200)	3.12018757
35	protein localization to chromosome, centromeric region (GO:0071459)	3.11886894
36	IMP metabolic process (GO:0046040)	3.09801956
37	tRNA aminoacylation for protein translation (GO:0006418)	3.09255022
38	proteasome assembly (GO:0043248)	3.08111739
39	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.07431768
40	IMP biosynthetic process (GO:0006188)	3.06193180
41	maturation of SSU-rRNA (GO:0030490)	3.04640265
42	mitotic nuclear envelope disassembly (GO:0007077)	3.04552771
43	regulation of mitotic spindle organization (GO:0060236)	3.01847211
44	viral transcription (GO:0019083)	3.01506372
45	proline biosynthetic process (GO:0006561)	3.00933828
46	serine family amino acid biosynthetic process (GO:0009070)	3.00870544
47	tRNA aminoacylation (GO:0043039)	3.00584799
48	amino acid activation (GO:0043038)	3.00584799
49	protein localization to kinetochore (GO:0034501)	3.00558135
50	deoxyribonucleotide biosynthetic process (GO:0009263)	2.99969936
51	urea metabolic process (GO:0019627)	2.99405305
52	ribonucleoprotein complex biogenesis (GO:0022613)	2.99019238
53	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.98095822
54	gluconeogenesis (GO:0006094)	2.97660374
55	respiratory electron transport chain (GO:0022904)	2.96639805
56	translational termination (GO:0006415)	2.95867220
57	folic acid metabolic process (GO:0046655)	2.94612645
58	urea cycle (GO:0000050)	2.93546872
59	ribosomal small subunit assembly (GO:0000028)	2.92968298
60	DNA replication initiation (GO:0006270)	2.92891362
61	negative regulation of ligase activity (GO:0051352)	2.91225329
62	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.91225329
63	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.89568331
64	telomere maintenance via recombination (GO:0000722)	2.86410485
65	cotranslational protein targeting to membrane (GO:0006613)	2.84825482
66	folic acid-containing compound biosynthetic process (GO:0009396)	2.84779318
67	electron transport chain (GO:0022900)	2.84131641
68	nucleobase biosynthetic process (GO:0046112)	2.83698728
69	translational initiation (GO:0006413)	2.83507805
70	nuclear envelope disassembly (GO:0051081)	2.81665307
71	membrane disassembly (GO:0030397)	2.81665307
72	protein targeting to ER (GO:0045047)	2.80724207
73	metaphase plate congression (GO:0051310)	2.80682551
74	tetrahydrofolate metabolic process (GO:0046653)	2.80270399
75	mitotic recombination (GO:0006312)	2.80009753
76	hexose biosynthetic process (GO:0019319)	2.77920542
77	CENP-A containing nucleosome assembly (GO:0034080)	2.76350765
78	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.76045253
79	nitrogen cycle metabolic process (GO:0071941)	2.74723773
80	kinetochore organization (GO:0051383)	2.72080529
81	mitochondrial fusion (GO:0008053)	2.72043141
82	monosaccharide biosynthetic process (GO:0046364)	2.71719664
83	L-phenylalanine metabolic process (GO:0006558)	2.71711724
84	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.71711724
85	ventricular cardiac muscle cell development (GO:0055015)	2.71022541
86	aerobic respiration (GO:0009060)	2.70635001
87	regulation of spindle organization (GO:0090224)	2.70622711
88	glyoxylate metabolic process (GO:0046487)	2.70302430
89	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.70012975
90	protein localization to endoplasmic reticulum (GO:0070972)	2.69455698
91	establishment of viral latency (GO:0019043)	2.69373997
92	ribosome biogenesis (GO:0042254)	2.68859413
93	muscle filament sliding (GO:0030049)	2.68507738
94	actin-myosin filament sliding (GO:0033275)	2.68507738
95	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.67965151
96	translational elongation (GO:0006414)	2.67948514
97	protein maturation by protein folding (GO:0022417)	2.66617731
98	inner mitochondrial membrane organization (GO:0007007)	2.65059420
99	DNA topological change (GO:0006265)	2.62743413
100	midgut development (GO:0007494)	2.62704398

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	7.37513800
2	MYC_18555785_ChIP-Seq_MESCs_Mouse	4.33100574
3	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	4.01760132
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.69007574
5	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.58757189
6	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.54844402
7	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.12411762
8	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.06174056
9	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.96025092
10	AR_21909140_ChIP-Seq_LNCAP_Human	2.92701593
11	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.92117155
12	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.86227264
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.84587705
14	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.77937060
15	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.63164313
16	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.56824660
17	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.50828821
18	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.49875933
19	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.46928890
20	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.46745906
21	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.41704491
22	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.32609630
23	* XRN2_22483619_ChIP-Seq_HELA_Human	2.31464243
24	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.29278105
25	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.24879047
26	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.22689557
27	DCP1A_22483619_ChIP-Seq_HELA_Human	2.21995349
28	ZNF263_19887448_ChIP-Seq_K562_Human	2.19901582
29	ZFX_18555785_ChIP-Seq_MESCs_Mouse	2.18360874
30	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.04828061
31	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.97049973
32	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.88076686
33	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.87131579
34	TTF2_22483619_ChIP-Seq_HELA_Human	1.85515169
35	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.83400500
36	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.74920541
37	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.71557620
38	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.66095417
39	GABP_19822575_ChIP-Seq_HepG2_Human	1.63757982
40	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.63746044
41	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.62232544
42	ELK1_19687146_ChIP-ChIP_HELA_Human	1.61896455
43	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.61867849
44	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.61057827
45	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.59555410
46	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.54423789
47	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.54389501
48	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.49623747
49	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.48926434
50	FOXP3_21729870_ChIP-Seq_TREG_Human	1.37953076
51	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.37363354
52	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.37084401
53	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.35186370
54	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.29468284
55	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.28878362
56	VDR_23849224_ChIP-Seq_CD4+_Human	1.28788414
57	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.27181216
58	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.25654768
59	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.25367009
60	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.24058084
61	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.22674592
62	* KDM5A_27292631_Chip-Seq_BREAST_Human	1.22546491
63	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.21725624
64	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.21441266
65	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.20810366
66	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.19330142
67	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.17416615
68	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.17299268
69	SOX17_20123909_ChIP-Seq_XEN_Mouse	1.17228961
70	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.16163987
71	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.15028983
72	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.14291870
73	* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.14246333
74	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.12767020
75	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.12197721
76	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.11139947
77	CLOCK_20551151_ChIP-Seq_293T_Human	1.10788734
78	TFEB_21752829_ChIP-Seq_HELA_Human	1.09925583
79	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.09779991
80	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.09244845
81	TBX5_21415370_ChIP-Seq_HL-1_Mouse	1.07425111
82	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.05736949
83	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.05153661
84	GATA4_21415370_ChIP-Seq_HL-1_Mouse	1.02242141
85	* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.01888673
86	NKX2-5_21415370_ChIP-Seq_HL-1_Mouse	1.01587038
87	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.00962797
88	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	1.00289360
89	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.93817496
90	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.93257268
91	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.92862208
92	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.91790357
93	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.91384528
94	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.90544103
95	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.89988859
96	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.86358851
97	CHD1_26751641_Chip-Seq_LNCaP_Human	0.86078773
98	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.85519763
99	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.84248695
100	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	0.83975022

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010094_abnormal_chromosome_stability	3.46750053
2	MP0003806_abnormal_nucleotide_metabolis	3.37231753
3	MP0003693_abnormal_embryo_hatching	3.28509605
4	MP0004957_abnormal_blastocyst_morpholog	3.27649071
5	MP0003111_abnormal_nucleus_morphology	3.07995703
6	MP0002139_abnormal_hepatobiliary_system	2.81626535
7	MP0009697_abnormal_copulation	2.79184980
8	MP0003077_abnormal_cell_cycle	2.71296527
9	MP0005451_abnormal_body_composition	2.67476723
10	MP0008932_abnormal_embryonic_tissue	2.62147630
11	MP0004233_abnormal_muscle_weight	2.59985224
12	MP0000751_myopathy	2.53000812
13	MP0008058_abnormal_DNA_repair	2.52320841
14	MP0000749_muscle_degeneration	2.37315850
15	MP0006036_abnormal_mitochondrial_physio	2.23812083
16	MP0005330_cardiomyopathy	2.05235790
17	MP0008057_abnormal_DNA_replication	2.03067160
18	MP0003186_abnormal_redox_activity	1.99035996
19	MP0008007_abnormal_cellular_replicative	1.92609741
20	MP0001661_extended_life_span	1.89725182
21	MP0004145_abnormal_muscle_electrophysio	1.84245979
22	MP0002269_muscular_atrophy	1.82395091
23	MP0002877_abnormal_melanocyte_morpholog	1.82079496
24	MP0001730_embryonic_growth_arrest	1.78072232
25	MP0000747_muscle_weakness	1.73650051
26	MP0005360_urolithiasis	1.72907076
27	MP0003705_abnormal_hypodermis_morpholog	1.71388981
28	MP0004036_abnormal_muscle_relaxation	1.70596024
29	MP0003646_muscle_fatigue	1.60792332
30	MP0004087_abnormal_muscle_fiber	1.55726340
31	MP0003718_maternal_effect	1.55347819
32	MP0010234_abnormal_vibrissa_follicle	1.51692548
33	MP0003221_abnormal_cardiomyocyte_apopto	1.50577447
34	MP0006035_abnormal_mitochondrial_morpho	1.47069200
35	MP0005085_abnormal_gallbladder_physiolo	1.46752827
36	MP0004084_abnormal_cardiac_muscle	1.45220492
37	MP0005408_hypopigmentation	1.45075523
38	MP0000759_abnormal_skeletal_muscle	1.41605675
39	MP0003786_premature_aging	1.41362454
40	MP0010030_abnormal_orbit_morphology	1.40194932
41	MP0002837_dystrophic_cardiac_calcinosis	1.39626246
42	MP0000350_abnormal_cell_proliferation	1.37439798
43	MP0005332_abnormal_amino_acid	1.30341935
44	MP0000372_irregular_coat_pigmentation	1.28465733
45	MP0004215_abnormal_myocardial_fiber	1.28154413
46	MP0001697_abnormal_embryo_size	1.24790580
47	MP0004147_increased_porphyrin_level	1.22619795
48	MP0002080_prenatal_lethality	1.22557595
49	MP0005365_abnormal_bile_salt	1.18373590
50	MP0009840_abnormal_foam_cell	1.17293653
51	MP0001672_abnormal_embryogenesis/_devel	1.16757954
52	MP0005380_embryogenesis_phenotype	1.16757954
53	MP0005257_abnormal_intraocular_pressure	1.16553713
54	MP0000750_abnormal_muscle_regeneration	1.16165591
55	MP0009672_abnormal_birth_weight	1.15674675
56	MP0002938_white_spotting	1.13502219
57	MP0000358_abnormal_cell_content/	1.12087106
58	MP0003868_abnormal_feces_composition	1.09361990
59	MP0001529_abnormal_vocalization	1.09048993
60	MP0010352_gastrointestinal_tract_polyps	1.07784332
61	MP0003984_embryonic_growth_retardation	1.06470039
62	MP0003950_abnormal_plasma_membrane	1.05577922
63	MP0002106_abnormal_muscle_physiology	1.05219170
64	MP0010630_abnormal_cardiac_muscle	1.04938383
65	MP0009379_abnormal_foot_pigmentation	1.03339892
66	MP0002972_abnormal_cardiac_muscle	1.03015748
67	MP0002088_abnormal_embryonic_growth/wei	1.01027529
68	MP0004185_abnormal_adipocyte_glucose	0.96828668
69	MP0005266_abnormal_metabolism	0.94960549
70	MP0005501_abnormal_skin_physiology	0.93204097
71	MP0003315_abnormal_perineum_morphology	0.92680466
72	MP0003656_abnormal_erythrocyte_physiolo	0.92629686
73	MP0000313_abnormal_cell_death	0.92395591
74	MP0001727_abnormal_embryo_implantation	0.90110045
75	MP0006138_congestive_heart_failure	0.89236108
76	MP0001764_abnormal_homeostasis	0.88836210
77	MP0008875_abnormal_xenobiotic_pharmacok	0.88787509
78	MP0002084_abnormal_developmental_patter	0.83849135
79	MP0003566_abnormal_cell_adhesion	0.81694443
80	MP0002085_abnormal_embryonic_tissue	0.81082981
81	MP0001544_abnormal_cardiovascular_syste	0.80159811
82	MP0005385_cardiovascular_system_phenoty	0.80159811
83	MP0005620_abnormal_muscle_contractility	0.79177673
84	MP0005369_muscle_phenotype	0.78116708
85	MP0008775_abnormal_heart_ventricle	0.77145391
86	MP0008789_abnormal_olfactory_epithelium	0.75941898
87	MP0001666_abnormal_nutrient_absorption	0.75451683
88	MP0002086_abnormal_extraembryonic_tissu	0.73084701
89	MP0000733_abnormal_muscle_development	0.72854479
90	MP0000003_abnormal_adipose_tissue	0.72568896
91	MP0002638_abnormal_pupillary_reflex	0.72358342
92	MP0002210_abnormal_sex_determination	0.71911582
93	MP0004272_abnormal_basement_membrane	0.71093793
94	MP0000609_abnormal_liver_physiology	0.70074494
95	MP0008438_abnormal_cutaneous_collagen	0.69761761
96	MP0000678_abnormal_parathyroid_gland	0.66981188
97	MP0005319_abnormal_enzyme/_coenzyme	0.66352347
98	MP0005666_abnormal_adipose_tissue	0.65776082
99	MP0010307_abnormal_tumor_latency	0.65523964
100	MP0003123_paternal_imprinting	0.65052453

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of glycolysis (HP:0004366)	4.72767813
2	Increased serum pyruvate (HP:0003542)	4.59308949
3	Nemaline bodies (HP:0003798)	4.11841871
4	Muscle fiber inclusion bodies (HP:0100299)	4.01635084
5	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	3.98974655
6	Exercise-induced muscle cramps (HP:0003710)	3.55352530
7	Rhabdomyolysis (HP:0003201)	3.55255845
8	Myoglobinuria (HP:0002913)	3.39741940
9	Abnormal gallbladder physiology (HP:0012438)	3.36279204
10	Cholecystitis (HP:0001082)	3.36279204
11	Abnormal mitochondria in muscle tissue (HP:0008316)	3.25510165
12	Acute encephalopathy (HP:0006846)	3.22175836
13	Cerebral edema (HP:0002181)	3.17102583
14	Acute necrotizing encephalopathy (HP:0006965)	3.05875999
15	Ragged-red muscle fibers (HP:0003200)	3.02516432
16	Exercise-induced myalgia (HP:0003738)	3.00243896
17	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.90656469
18	Abnormality of methionine metabolism (HP:0010901)	2.74556517
19	Increased intramyocellular lipid droplets (HP:0012240)	2.74312671
20	Progressive muscle weakness (HP:0003323)	2.67760376
21	Hepatic necrosis (HP:0002605)	2.67461704
22	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.65790476
23	Hyperammonemia (HP:0001987)	2.63345619
24	Hypobetalipoproteinemia (HP:0003563)	2.61198322
25	Reticulocytopenia (HP:0001896)	2.55203797
26	Centrally nucleated skeletal muscle fibers (HP:0003687)	2.54687513
27	Microvesicular hepatic steatosis (HP:0001414)	2.52638647
28	Exercise intolerance (HP:0003546)	2.52457037
29	Type 1 muscle fiber predominance (HP:0003803)	2.50460474
30	Increased CSF lactate (HP:0002490)	2.50319497
31	Increased muscle lipid content (HP:0009058)	2.46884648
32	Cholelithiasis (HP:0001081)	2.46363915
33	Increased connective tissue (HP:0009025)	2.43327012
34	Macrocytic anemia (HP:0001972)	2.43008671
35	Rimmed vacuoles (HP:0003805)	2.42545616
36	Hepatocellular necrosis (HP:0001404)	2.40896345
37	Mitochondrial inheritance (HP:0001427)	2.39996337
38	Cortical dysplasia (HP:0002539)	2.38269646
39	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.37739842
40	EMG: myopathic abnormalities (HP:0003458)	2.37590199
41	Increased hepatocellular lipid droplets (HP:0006565)	2.37242871
42	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.36903812
43	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.36903812
44	Lipid accumulation in hepatocytes (HP:0006561)	2.32762755
45	Chromsome breakage (HP:0040012)	2.31837708
46	Reduced antithrombin III activity (HP:0001976)	2.27063230
47	Gout (HP:0001997)	2.26686558
48	Myopathic facies (HP:0002058)	2.26134029
49	Achilles tendon contracture (HP:0001771)	2.25693137
50	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.24602107
51	* Lactic acidosis (HP:0003128)	2.23945666
52	Increased serum lactate (HP:0002151)	2.23469048
53	Progressive macrocephaly (HP:0004481)	2.22680807
54	Abnormality of reticulocytes (HP:0004312)	2.21549945
55	Abnormal gallbladder morphology (HP:0012437)	2.19995418
56	Calcaneovalgus deformity (HP:0001848)	2.19681765
57	Generalized aminoaciduria (HP:0002909)	2.18965273
58	Abnormality of the Achilles tendon (HP:0005109)	2.18929383
59	Multiple enchondromatosis (HP:0005701)	2.12777807
60	Abnormality of serum amino acid levels (HP:0003112)	2.11546033
61	Shoulder girdle muscle weakness (HP:0003547)	2.11502129
62	Hypoglycemic coma (HP:0001325)	2.11176106
63	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.07718491
64	Abnormality of alanine metabolism (HP:0010916)	2.07718491
65	Hyperalaninemia (HP:0003348)	2.07718491
66	Muscle stiffness (HP:0003552)	2.06097146
67	Reticulocytosis (HP:0001923)	2.05608647
68	Abnormality of fatty-acid metabolism (HP:0004359)	2.04836058
69	Distal lower limb muscle weakness (HP:0009053)	2.04279048
70	Neck muscle weakness (HP:0000467)	2.03077810
71	Abnormality of the tricuspid valve (HP:0001702)	2.02224200
72	Sudden death (HP:0001699)	2.02217651
73	Hypokinesia (HP:0002375)	2.01184511
74	Progressive external ophthalmoplegia (HP:0000590)	1.95446803
75	Dilated cardiomyopathy (HP:0001644)	1.94663008
76	Abnormality of pyrimidine metabolism (HP:0004353)	1.93360429
77	Abnormality of cells of the erythroid lineage (HP:0012130)	1.92962154
78	Hypolipoproteinemia (HP:0010981)	1.90377527
79	Prolonged partial thromboplastin time (HP:0003645)	1.88041642
80	Respiratory failure (HP:0002878)	1.85562414
81	Birth length less than 3rd percentile (HP:0003561)	1.85135521
82	Deformed tarsal bones (HP:0008119)	1.83890857
83	Intrahepatic cholestasis (HP:0001406)	1.83262006
84	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.83259537
85	Overlapping toe (HP:0001845)	1.82707638
86	Abnormality of the calf musculature (HP:0001430)	1.82579307
87	Abnormality of the gallbladder (HP:0005264)	1.81596640
88	Hyperbilirubinemia (HP:0002904)	1.81386236
89	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.81089969
90	Type I transferrin isoform profile (HP:0003642)	1.80053524
91	Lipoatrophy (HP:0100578)	1.79538862
92	Abnormality of the anterior horn cell (HP:0006802)	1.78914536
93	Degeneration of anterior horn cells (HP:0002398)	1.78914536
94	Palpitations (HP:0001962)	1.78797682
95	Nausea (HP:0002018)	1.75928400
96	Bundle branch block (HP:0011710)	1.75625813
97	Ventricular tachycardia (HP:0004756)	1.75233915
98	Limb-girdle muscle atrophy (HP:0003797)	1.74893489
99	Abnormality of the calcaneus (HP:0008364)	1.74720540
100	Deep venous thrombosis (HP:0002625)	1.74607633

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NEK1	4.28614430
2	BUB1	3.91551287
3	TTK	3.04347900
4	PBK	2.99079269
5	NME2	2.94517762
6	EIF2AK1	2.87112511
7	CDC7	2.82433094
8	PDK2	2.79710248
9	OBSCN	2.43356297
10	SRPK1	2.39163336
11	SCYL2	2.29490756
12	WEE1	2.17768532
13	TTN	2.16016075
14	TSSK6	1.98870014
15	VRK2	1.95301787
16	MST1R	1.92723537
17	EIF2AK3	1.89163669
18	CCNB1	1.84390881
19	STK16	1.71832917
20	NME1	1.60730629
21	MAP3K12	1.57775523
22	PAK4	1.48912101
23	PLK4	1.42094241
24	IRAK3	1.38250543
25	LATS2	1.35432778
26	BRSK2	1.33660115
27	PLK1	1.32977713
28	ARAF	1.31411818
29	BRSK1	1.28876320
30	MET	1.21605079
31	RPS6KB2	1.20396819
32	AURKB	1.17661091
33	BRAF	1.17109161
34	PHKG1	1.16202668
35	PHKG2	1.16202668
36	ICK	1.14795865
37	LIMK1	1.12573098
38	CHEK2	1.09944750
39	SMG1	1.08304324
40	PLK3	1.07813219
41	EEF2K	1.05541131
42	AURKA	1.04202151
43	MAP3K8	1.04143645
44	NEK9	0.99878044
45	NEK2	0.98022265
46	KSR2	0.95762087
47	CDK7	0.90990166
48	VRK1	0.89067803
49	MYLK	0.88380191
50	ATR	0.87031883
51	TESK1	0.86962877
52	ZAK	0.81722492
53	ERBB4	0.81469496
54	EPHA2	0.81263647
55	CDK8	0.80268592
56	CHEK1	0.79644362
57	RAF1	0.79190344
58	PIM2	0.74326206
59	AKT2	0.73479617
60	TAF1	0.71345339
61	ILK	0.65365170
62	BCKDK	0.63756297
63	MKNK1	0.62086083
64	CLK1	0.62080761
65	CSNK2A2	0.59091851
66	STK4	0.57025773
67	ABL2	0.54841854
68	CDK11A	0.54427825
69	EIF2AK2	0.53695644
70	TAOK2	0.52303577
71	PTK2	0.51930891
72	CDK14	0.51243006
73	KSR1	0.51231216
74	DAPK3	0.50978775
75	CDK4	0.50792113
76	CDK15	0.50512845
77	PAK1	0.50439415
78	CSNK2A1	0.49870612
79	MAPKAPK5	0.49802401
80	ALK	0.49760977
81	CDK18	0.49104703
82	MOS	0.49084876
83	CDK1	0.48981340
84	ATM	0.47955509
85	CSNK1E	0.46635295
86	ERBB3	0.44158631
87	CDK2	0.42090283
88	PAK2	0.40274391
89	MST4	0.40180648
90	CDK6	0.40018841
91	TRIB3	0.38586170
92	CAMK2G	0.38106646
93	DMPK	0.37801595
94	PASK	0.36182827
95	TESK2	0.36052831
96	CSNK1G3	0.33380028
97	STK24	0.29990323
98	MAP3K10	0.29086579
99	DAPK1	0.28868797
100	LMTK2	0.28568622

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	* Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	3.50866689
2	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.27397958
3	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.99423856
4	DNA replication_Homo sapiens_hsa03030	2.94790169
5	Proteasome_Homo sapiens_hsa03050	2.64359909
6	Mismatch repair_Homo sapiens_hsa03430	2.52848464
7	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.45059238
8	Biosynthesis of amino acids_Homo sapiens_hsa01230	2.42240701
9	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.40189419
10	Ribosome_Homo sapiens_hsa03010	2.37674236
11	* Carbon metabolism_Homo sapiens_hsa01200	2.32449281
12	* Pyruvate metabolism_Homo sapiens_hsa00620	2.18800454
13	Oxidative phosphorylation_Homo sapiens_hsa00190	1.90731183
14	Parkinsons disease_Homo sapiens_hsa05012	1.90254741
15	Arginine biosynthesis_Homo sapiens_hsa00220	1.88111281
16	One carbon pool by folate_Homo sapiens_hsa00670	1.78904899
17	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.75818299
18	Pentose phosphate pathway_Homo sapiens_hsa00030	1.69072964
19	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.68986846
20	Nucleotide excision repair_Homo sapiens_hsa03420	1.67313150
21	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.61463349
22	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.59878503
23	Propanoate metabolism_Homo sapiens_hsa00640	1.50344541
24	Base excision repair_Homo sapiens_hsa03410	1.49491271
25	Cell cycle_Homo sapiens_hsa04110	1.47641984
26	RNA transport_Homo sapiens_hsa03013	1.43841758
27	Fatty acid elongation_Homo sapiens_hsa00062	1.41602403
28	Sulfur relay system_Homo sapiens_hsa04122	1.39554259
29	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.38065256
30	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.37568662
31	Phenylalanine metabolism_Homo sapiens_hsa00360	1.36717425
32	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.36664112
33	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.36642234
34	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.35515074
35	Spliceosome_Homo sapiens_hsa03040	1.32813173
36	Fatty acid degradation_Homo sapiens_hsa00071	1.25996402
37	Huntingtons disease_Homo sapiens_hsa05016	1.23440017
38	Arginine and proline metabolism_Homo sapiens_hsa00330	1.21158934
39	Alzheimers disease_Homo sapiens_hsa05010	1.20881238
40	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.20606600
41	Pyrimidine metabolism_Homo sapiens_hsa00240	1.20511976
42	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.20327162
43	Homologous recombination_Homo sapiens_hsa03440	1.20166531
44	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.17803460
45	Cardiac muscle contraction_Homo sapiens_hsa04260	1.15891917
46	Folate biosynthesis_Homo sapiens_hsa00790	1.12647468
47	Sulfur metabolism_Homo sapiens_hsa00920	1.08867178
48	Non-homologous end-joining_Homo sapiens_hsa03450	1.07537945
49	Tyrosine metabolism_Homo sapiens_hsa00350	1.07413019
50	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.05763993
51	Fatty acid metabolism_Homo sapiens_hsa01212	1.05194191
52	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.04588168
53	Protein export_Homo sapiens_hsa03060	1.04179820
54	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.00995172
55	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.00986487
56	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.99614071
57	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.98133102
58	Glutathione metabolism_Homo sapiens_hsa00480	0.96407820
59	Fanconi anemia pathway_Homo sapiens_hsa03460	0.94303945
60	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.94018073
61	RNA polymerase_Homo sapiens_hsa03020	0.93246371
62	Galactose metabolism_Homo sapiens_hsa00052	0.89825409
63	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.86798155
64	Steroid biosynthesis_Homo sapiens_hsa00100	0.84297751
65	Butanoate metabolism_Homo sapiens_hsa00650	0.84007297
66	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.73585334
67	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.71290858
68	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.70014976
69	* Metabolic pathways_Homo sapiens_hsa01100	0.69011615
70	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.66890527
71	Peroxisome_Homo sapiens_hsa04146	0.65273855
72	Purine metabolism_Homo sapiens_hsa00230	0.65136732
73	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.64424624
74	Retinol metabolism_Homo sapiens_hsa00830	0.63299269
75	mRNA surveillance pathway_Homo sapiens_hsa03015	0.62322079
76	Tryptophan metabolism_Homo sapiens_hsa00380	0.61231523
77	Oocyte meiosis_Homo sapiens_hsa04114	0.60895122
78	RNA degradation_Homo sapiens_hsa03018	0.59575706
79	Caffeine metabolism_Homo sapiens_hsa00232	0.58332462
80	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.57098734
81	beta-Alanine metabolism_Homo sapiens_hsa00410	0.53102826
82	Prion diseases_Homo sapiens_hsa05020	0.51851892
83	Chemical carcinogenesis_Homo sapiens_hsa05204	0.51401078
84	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.51208096
85	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.48353319
86	Basal transcription factors_Homo sapiens_hsa03022	0.44712592
87	Selenocompound metabolism_Homo sapiens_hsa00450	0.42241308
88	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.41114272
89	Complement and coagulation cascades_Homo sapiens_hsa04610	0.39518524
90	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.38846596
91	PPAR signaling pathway_Homo sapiens_hsa03320	0.37516806
92	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.36702108
93	p53 signaling pathway_Homo sapiens_hsa04115	0.35343042
94	Thyroid cancer_Homo sapiens_hsa05216	0.34999826
95	Lysine degradation_Homo sapiens_hsa00310	0.32224001
96	Vibrio cholerae infection_Homo sapiens_hsa05110	0.30342376
97	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.28295123
98	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.27653008
99	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.24557204
100	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.23873531

FH

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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