FHDC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1oxygen transport (GO:0015671)9.13888307
2gas transport (GO:0015669)8.32223337
3porphyrin-containing compound biosynthetic process (GO:0006779)7.77876765
4heme biosynthetic process (GO:0006783)7.06726320
5erythrocyte maturation (GO:0043249)6.83350247
6tetrapyrrole biosynthetic process (GO:0033014)6.80632579
7desmosome organization (GO:0002934)6.44702474
8response to methylmercury (GO:0051597)6.21327589
9porphyrin-containing compound metabolic process (GO:0006778)5.92026896
10hemoglobin metabolic process (GO:0020027)5.68831386
11hemidesmosome assembly (GO:0031581)5.53763466
12heme metabolic process (GO:0042168)5.26800304
13glycine transport (GO:0015816)5.23148217
14cytoskeletal anchoring at plasma membrane (GO:0007016)5.05946360
15regulation of water loss via skin (GO:0033561)4.98925891
16establishment of skin barrier (GO:0061436)4.95305460
17regulation of response to osmotic stress (GO:0047484)4.79101252
18erythrocyte development (GO:0048821)4.64384473
19peptide cross-linking (GO:0018149)4.53172894
20regulation of posttranscriptional gene silencing (GO:0060147)4.45973036
21regulation of gene silencing by miRNA (GO:0060964)4.45973036
22regulation of gene silencing by RNA (GO:0060966)4.45973036
23somatic diversification of immune receptors via somatic mutation (GO:0002566)4.45513345
24somatic hypermutation of immunoglobulin genes (GO:0016446)4.45513345
25keratinization (GO:0031424)4.39161020
26response to insecticide (GO:0017085)4.33551293
27COPI coating of Golgi vesicle (GO:0048205)4.23786988
28Golgi transport vesicle coating (GO:0048200)4.23786988
29response to lead ion (GO:0010288)4.14168662
30one-carbon compound transport (GO:0019755)4.07058494
31determination of adult lifespan (GO:0008340)4.06505746
32multicellular organismal water homeostasis (GO:0050891)4.03800516
33negative regulation of translation, ncRNA-mediated (GO:0040033)3.87415406
34regulation of translation, ncRNA-mediated (GO:0045974)3.87415406
35negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.87415406
36mesodermal cell differentiation (GO:0048333)3.86706889
37erythrocyte differentiation (GO:0030218)3.76796992
38protein-cofactor linkage (GO:0018065)3.76574593
39tetrapyrrole metabolic process (GO:0033013)3.70382434
40negative regulation of execution phase of apoptosis (GO:1900118)3.68469061
41bicarbonate transport (GO:0015701)3.61017846
42regulation of RNA export from nucleus (GO:0046831)3.57293219
43response to arsenic-containing substance (GO:0046685)3.56864641
44antibacterial humoral response (GO:0019731)3.46095579
45positive regulation of p38MAPK cascade (GO:1900745)3.44183225
46regulation of helicase activity (GO:0051095)3.39780642
47myeloid cell development (GO:0061515)3.39066900
48hair cycle (GO:0042633)3.34639434
49molting cycle (GO:0042303)3.34639434
50atrioventricular valve morphogenesis (GO:0003181)3.29806485
51skin morphogenesis (GO:0043589)3.28374761
52N-terminal protein amino acid acetylation (GO:0006474)3.25009709
53activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.24403060
54DNA damage response, signal transduction resulting in transcription (GO:0042772)3.19356227
55innate immune response in mucosa (GO:0002227)3.18486543
56antimicrobial humoral response (GO:0019730)3.18356978
57water homeostasis (GO:0030104)3.18179718
58pre-miRNA processing (GO:0031054)3.17982360
59negative regulation of viral entry into host cell (GO:0046597)3.14149208
60negative regulation of inclusion body assembly (GO:0090084)3.13215491
61positive regulation of nuclease activity (GO:0032075)3.12467088
62heme transport (GO:0015886)3.12167298
63maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.11941365
64hydrogen peroxide catabolic process (GO:0042744)3.05660993
65mucosal immune response (GO:0002385)3.05331042
66keratinocyte differentiation (GO:0030216)3.00707489
67positive regulation of megakaryocyte differentiation (GO:0045654)2.99493279
68regulation of hippo signaling (GO:0035330)2.98706281
69intestinal epithelial cell development (GO:0060576)2.95630466
70iron ion import (GO:0097286)2.95502370
71organ or tissue specific immune response (GO:0002251)2.93332916
72phosphatidylcholine biosynthetic process (GO:0006656)2.92886403
73bundle of His cell to Purkinje myocyte communication (GO:0086069)2.91442460
74protein targeting to plasma membrane (GO:0072661)2.90730250
75surfactant homeostasis (GO:0043129)2.90617860
76regulation of p38MAPK cascade (GO:1900744)2.90191590
77regulation of stem cell maintenance (GO:2000036)2.88094933
78actin filament capping (GO:0051693)2.87333263
79cell wall macromolecule catabolic process (GO:0016998)2.85624210
80cell wall macromolecule metabolic process (GO:0044036)2.85624210
81endoplasmic reticulum unfolded protein response (GO:0030968)2.84853893
82establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.81215628
83regulation of nuclease activity (GO:0032069)2.78892633
84establishment of epithelial cell polarity (GO:0090162)2.76968341
85cellular response to unfolded protein (GO:0034620)2.76819837
86protein retention in ER lumen (GO:0006621)2.76449751
87cysteine metabolic process (GO:0006534)2.75474445
88thyroid hormone generation (GO:0006590)2.74559059
89endocrine pancreas development (GO:0031018)2.74286714
90pigment biosynthetic process (GO:0046148)2.72817378
91neutral amino acid transport (GO:0015804)2.67699572
92homocysteine metabolic process (GO:0050667)2.67675904
93chromatin assembly (GO:0031497)2.66802701
94phosphatidylethanolamine biosynthetic process (GO:0006646)2.65937278
95ectoderm development (GO:0007398)2.64919877
96DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.64245626
97astrocyte differentiation (GO:0048708)2.63769194
98positive regulation of gluconeogenesis (GO:0045722)2.63682264
99gland morphogenesis (GO:0022612)2.61843618
100estrogen biosynthetic process (GO:0006703)2.61551705
101negative regulation of DNA recombination (GO:0045910)2.60792123
102intermediate filament organization (GO:0045109)2.59847213
103phosphatidylethanolamine metabolic process (GO:0046337)2.58862516
104ER-nucleus signaling pathway (GO:0006984)2.57056523
105iron coordination entity transport (GO:1901678)2.56639203
106hepatocyte apoptotic process (GO:0097284)2.56619563
107regulation of nucleobase-containing compound transport (GO:0032239)2.55790223
108thyroid hormone metabolic process (GO:0042403)2.55630162
109regulation of histone H3-K9 methylation (GO:0051570)2.54134835
110negative regulation of actin filament depolymerization (GO:0030835)2.54048581
111regulation of integrin-mediated signaling pathway (GO:2001044)2.53733110
112regulation of type B pancreatic cell apoptotic process (GO:2000674)2.53547314
113negative regulation of fatty acid transport (GO:2000192)2.53232737
114epidermal cell differentiation (GO:0009913)2.52660601
115ovulation from ovarian follicle (GO:0001542)2.52464053
116definitive hemopoiesis (GO:0060216)2.51721678
117stress fiber assembly (GO:0043149)2.51677352
118negative regulation of histone methylation (GO:0031061)2.50735403
119cellular response to topologically incorrect protein (GO:0035967)2.50392603
120positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.49230673
121regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.49230673
122positive regulation of histone deacetylation (GO:0031065)2.49067134
123fusion of sperm to egg plasma membrane (GO:0007342)2.49004741
124pigment metabolic process (GO:0042440)2.47995326
125cell-substrate junction assembly (GO:0007044)2.47909858
126cellular response to vitamin D (GO:0071305)2.47604898
127microtubule depolymerization (GO:0007019)2.47185584
128positive regulation of erythrocyte differentiation (GO:0045648)2.47008331
129granulocyte differentiation (GO:0030851)2.46771292
130amino acid transmembrane transport (GO:0003333)2.46614365
131chromatin silencing (GO:0006342)2.46511347
132epithelial cell-cell adhesion (GO:0090136)2.46007629
133regulation of viral entry into host cell (GO:0046596)2.45520094
134regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.45143838
135positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.45143838
136establishment or maintenance of bipolar cell polarity (GO:0061245)2.44359453
137establishment or maintenance of apical/basal cell polarity (GO:0035088)2.44359453
138negative regulation of smooth muscle cell differentiation (GO:0051151)2.42962224
139platelet formation (GO:0030220)2.40763539
140embryonic hemopoiesis (GO:0035162)2.40743818
141negative regulation of keratinocyte proliferation (GO:0010839)2.40554238
142COPII vesicle coating (GO:0048208)2.40484188
143decidualization (GO:0046697)2.39884701
144epidermis development (GO:0008544)2.37818874
145polarized epithelial cell differentiation (GO:0030859)2.37331504
146positive regulation of mRNA catabolic process (GO:0061014)2.36194992
147L-alpha-amino acid transmembrane transport (GO:1902475)2.35579741
1483-UTR-mediated mRNA stabilization (GO:0070935)2.35202038
149regulation of gene silencing (GO:0060968)2.33765695
150type B pancreatic cell development (GO:0003323)2.33017557
151response to nitrosative stress (GO:0051409)2.31917602
152positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.31356226
153regulation of nuclear cell cycle DNA replication (GO:0033262)2.28327886
154disruption of cells of other organism (GO:0044364)2.27112321
155killing of cells of other organism (GO:0031640)2.27112321
156histone H3-K36 demethylation (GO:0070544)2.26862491
157hematopoietic stem cell differentiation (GO:0060218)2.26578700
158positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.25179278
159response to iron ion (GO:0010039)2.23612155
160regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.22804021
161regulation of centriole replication (GO:0046599)2.22427168
162protoporphyrinogen IX metabolic process (GO:0046501)12.1563307
163protoporphyrinogen IX biosynthetic process (GO:0006782)10.9096335

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.51670283
2E2F7_22180533_ChIP-Seq_HELA_Human7.77422026
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.54596323
4GATA1_19941826_ChIP-Seq_K562_Human4.23667573
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.10212851
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.49285614
7GATA1_22025678_ChIP-Seq_K562_Human3.32902708
8* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse3.18268081
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.99175866
10ZNF263_19887448_ChIP-Seq_K562_Human2.87411908
11* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse2.76897646
12GATA2_19941826_ChIP-Seq_K562_Human2.50654787
13ZNF274_21170338_ChIP-Seq_K562_Hela2.49191881
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.36593060
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.24709964
16EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.24305790
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.21293023
18* GATA1_19941827_ChIP-Seq_MEL_Mouse2.14904055
19ESR1_21235772_ChIP-Seq_MCF-7_Human1.94803469
20RARG_19884340_ChIP-ChIP_MEFs_Mouse1.91173183
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.83214446
22POU5F1_16153702_ChIP-ChIP_HESCs_Human1.82201252
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.80970149
24SOX9_24532713_ChIP-Seq_HFSC_Mouse1.79902852
25IGF1R_20145208_ChIP-Seq_DFB_Human1.78608190
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.75883637
27P63_26484246_Chip-Seq_KERATINOCYTES_Human1.74521381
28SOX2_27498859_Chip-Seq_STOMACH_Mouse1.72074475
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.71319823
30SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.70523497
31SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.70523497
32KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.70134450
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.67858112
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64362696
35HIF1A_21447827_ChIP-Seq_MCF-7_Human1.58941515
36GATA6_25053715_ChIP-Seq_YYC3_Human1.58422890
37* FOXO3_23340844_ChIP-Seq_DLD1_Human1.56588496
38CLOCK_20551151_ChIP-Seq_293T_Human1.56141662
39* KDM2B_26808549_Chip-Seq_K562_Human1.52444376
40ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.50992928
41ATF3_27146783_Chip-Seq_COLON_Human1.49935228
42KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.48727607
43SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.44947785
44RACK7_27058665_Chip-Seq_MCF-7_Human1.43161549
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42067036
46HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.41099756
47FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.39907906
48RUNX1_27514584_Chip-Seq_MCF-7_Human1.39848046
49HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.37797047
50TBX3_20139965_ChIP-Seq_ESCs_Mouse1.36600118
51TBX3_20139965_ChIP-Seq_MESCs_Mouse1.36255784
52* SCL_19346495_ChIP-Seq_HPC-7_Human1.35656269
53* KLF5_25053715_ChIP-Seq_YYC3_Human1.35330237
54TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33410281
55STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.33109444
56GATA1_22383799_ChIP-Seq_G1ME_Mouse1.31299053
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.30672668
58TP53_22573176_ChIP-Seq_HFKS_Human1.30600336
59GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.30479904
60* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27544703
61TAF15_26573619_Chip-Seq_HEK293_Human1.26807174
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26637338
63E2F4_17652178_ChIP-ChIP_JURKAT_Human1.26529518
64ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25413146
65* GATA4_25053715_ChIP-Seq_YYC3_Human1.24564644
66ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.23231151
67* UBF1/2_26484160_Chip-Seq_HMECs_Human1.22926272
68PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22344268
69TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22176912
70GATA1_26923725_Chip-Seq_HPCs_Mouse1.21812557
71* NCOR1_26117541_ChIP-Seq_K562_Human1.21460446
72SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21089806
73FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.20896651
74SOX2_20726797_ChIP-Seq_SW620_Human1.18761851
75P300_27058665_Chip-Seq_ZR-75-30cells_Human1.18093395
76PPAR_26484153_Chip-Seq_NCI-H1993_Human1.17192279
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16736781
78KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.15405344
79POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15297072
80* KDM2B_26808549_Chip-Seq_DND41_Human1.12020047
81RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.10476668
82GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09720005
83ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09564916
84TCF7_22412390_ChIP-Seq_EML_Mouse1.08940774
85* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08553173
86ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.08381744
87CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08025804
88TCF3_18692474_ChIP-Seq_MESCs_Mouse1.07710058
89LXR_22292898_ChIP-Seq_THP-1_Human1.07478343
90E2F1_21310950_ChIP-Seq_MCF-7_Human1.07203039
91FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.07021400
92FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06822622
93NANOG_16153702_ChIP-ChIP_HESCs_Human1.05565881
94JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05181809
95NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.04974710
96FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04065760
97KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02440585
98HOXB7_26014856_ChIP-Seq_BT474_Human1.02251499
99* P300_19829295_ChIP-Seq_ESCs_Human1.01393880
100KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00464068
101VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00385268
102EST1_17652178_ChIP-ChIP_JURKAT_Human1.00171804
103ER_23166858_ChIP-Seq_MCF-7_Human1.00155593
104KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99314604
105GATA2_21666600_ChIP-Seq_HMVEC_Human0.99107393
106ELK3_25401928_ChIP-Seq_HUVEC_Human0.98828966
107CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98638935
108ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98011663
109SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97968939
110TDRD3_21172665_ChIP-Seq_MCF-7_Human0.97500155
111CREB1_26743006_Chip-Seq_LNCaP_Human0.96998520
112NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96100339
113FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.95598890
114FUS_26573619_Chip-Seq_HEK293_Human0.95442259
115SMAD3_21741376_ChIP-Seq_HESCs_Human0.95269331
116CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95141333
117YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94698204
118TP63_22573176_ChIP-Seq_HFKS_Human0.94532104
119* CJUN_26792858_Chip-Seq_BT549_Human0.94485741
120GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94334364
121POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94189700
122TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94189700
123GATA3_24758297_ChIP-Seq_MCF-7_Human0.93860868
124BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93151620
125ELF1_20517297_ChIP-Seq_JURKAT_Human0.92991896
126SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92632927
127KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.92196462
128IRF1_19129219_ChIP-ChIP_H3396_Human0.92166423
129JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92161221
130FOXA1_25552417_ChIP-Seq_VCAP_Human0.90685426
131* TP63_23658742_ChIP-Seq_EP156T_Human0.90373367
132EWS_26573619_Chip-Seq_HEK293_Human0.89205223
133GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.88595626
134CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.87883026
135PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.87448877
136UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.87440332
137OCT1_27270436_Chip-Seq_PROSTATE_Human0.87284311
138CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.86515884
139HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.86370702
140AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.86118088
141POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.85691955
142* CDX2_22108803_ChIP-Seq_LS180_Human0.84442983
143PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.84138629
144FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.84045255
145CTBP1_25329375_ChIP-Seq_LNCAP_Human0.83731459
146SA1_27219007_Chip-Seq_ERYTHROID_Human0.82081429
147SOX2_16153702_ChIP-ChIP_HESCs_Human0.80575187
148SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.80535537
149SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.80323295
150KDM2B_26808549_Chip-Seq_SUP-B15_Human0.80311130
151* KDM2B_26808549_Chip-Seq_JURKAT_Human0.79881011
152CHD1_26751641_Chip-Seq_LNCaP_Human0.79614836
153PKCTHETA_26484144_Chip-Seq_BREAST_Human0.79495663
154ETV1_20927104_ChIP-Seq_GIST48_Human0.79230028
155DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.78682289
156MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.78155378
157NANOG_21062744_ChIP-ChIP_HESCs_Human0.77688699
158CBX2_22325352_ChIP-Seq_293T-Rex_Human0.76774703
159IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.76337695
160CBP_20019798_ChIP-Seq_JUKART_Human0.76337695
161TP53_22127205_ChIP-Seq_IMR90_Human0.76175753
162RBPJ_21746931_ChIP-Seq_IB4_Human0.75906081
163AR_21909140_ChIP-Seq_LNCAP_Human0.74858261
164CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.74703830
165* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.74496444
166ETS1_22383799_ChIP-Seq_G1ME_Mouse0.74289884
167TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.73181683
168TBL1_22424771_ChIP-Seq_293T_Human0.72704610
169CEBPB_22108803_ChIP-Seq_LS180_Human0.72619499
170FLI1_27457419_Chip-Seq_LIVER_Mouse0.72440280

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo6.57435307
2MP0004147_increased_porphyrin_level4.58667673
3MP0010234_abnormal_vibrissa_follicle4.14885311
4MP0002877_abnormal_melanocyte_morpholog4.10731030
5MP0002796_impaired_skin_barrier4.01575487
6MP0005275_abnormal_skin_tensile3.97277730
7MP0005501_abnormal_skin_physiology3.21855105
8MP0008995_early_reproductive_senescence2.77188277
9MP0003283_abnormal_digestive_organ2.72405874
10MP0003705_abnormal_hypodermis_morpholog2.59911711
11MP0005083_abnormal_biliary_tract2.59602013
12MP0002060_abnormal_skin_morphology2.54577051
13MP0003878_abnormal_ear_physiology2.51039354
14MP0005377_hearing/vestibular/ear_phenot2.51039354
15MP0000579_abnormal_nail_morphology2.35748814
16MP0001188_hyperpigmentation2.35065653
17MP0003566_abnormal_cell_adhesion2.30428809
18MP0002098_abnormal_vibrissa_morphology2.29455973
19MP0002822_catalepsy2.28053178
20MP0010678_abnormal_skin_adnexa2.23057806
21MP0003941_abnormal_skin_development2.15205308
22MP0004264_abnormal_extraembryonic_tissu2.14625388
23MP0010771_integument_phenotype2.06101581
24MP0000383_abnormal_hair_follicle2.04670124
25MP0002234_abnormal_pharynx_morphology1.99495386
26MP0001216_abnormal_epidermal_layer1.92142979
27MP0003300_gastrointestinal_ulcer1.91592315
28MP0001529_abnormal_vocalization1.87773332
29MP0008877_abnormal_DNA_methylation1.86683535
30MP0005410_abnormal_fertilization1.84101650
31MP0003453_abnormal_keratinocyte_physiol1.81588281
32MP0003890_abnormal_embryonic-extraembry1.80471346
33MP0000647_abnormal_sebaceous_gland1.74757479
34MP0001346_abnormal_lacrimal_gland1.74633315
35MP0004947_skin_inflammation1.65150655
36MP0006054_spinal_hemorrhage1.62466701
37MP0010352_gastrointestinal_tract_polyps1.60282357
38MP0002254_reproductive_system_inflammat1.59844463
39MP0009931_abnormal_skin_appearance1.58409211
40MP0005076_abnormal_cell_differentiation1.57513802
41MP0005075_abnormal_melanosome_morpholog1.49099839
42MP0000762_abnormal_tongue_morphology1.48439322
43MP0004272_abnormal_basement_membrane1.46776826
44MP0000467_abnormal_esophagus_morphology1.44765212
45MP0000377_abnormal_hair_follicle1.43707302
46MP0002009_preneoplasia1.42148156
47MP0003136_yellow_coat_color1.41314478
48MP0004885_abnormal_endolymph1.37324121
49MP0000462_abnormal_digestive_system1.35907045
50MP0001849_ear_inflammation1.34850492
51MP0009053_abnormal_anal_canal1.33209589
52MP0002653_abnormal_ependyma_morphology1.30589486
53MP0009278_abnormal_bone_marrow1.29865368
54MP0010030_abnormal_orbit_morphology1.28613731
55MP0009780_abnormal_chondrocyte_physiolo1.28119067
56MP0000013_abnormal_adipose_tissue1.25577694
57MP0002896_abnormal_bone_mineralization1.25426060
58MP0008058_abnormal_DNA_repair1.25406924
59MP0001191_abnormal_skin_condition1.25098619
60MP0001243_abnormal_dermal_layer1.24377427
61MP0005623_abnormal_meninges_morphology1.22967689
62MP0000427_abnormal_hair_cycle1.21861782
63MP0002909_abnormal_adrenal_gland1.20538069
64MP0008872_abnormal_physiological_respon1.18577093
65MP0008438_abnormal_cutaneous_collagen1.18471312
66MP0002095_abnormal_skin_pigmentation1.17273372
67MP0001944_abnormal_pancreas_morphology1.15865993
68MP0000003_abnormal_adipose_tissue1.15495920
69MP0005636_abnormal_mineral_homeostasis1.14633050
70MP0003693_abnormal_embryo_hatching1.09065478
71MP0000537_abnormal_urethra_morphology1.08337671
72MP0004185_abnormal_adipocyte_glucose1.03633903
73MP0003011_delayed_dark_adaptation1.02893157
74MP0004782_abnormal_surfactant_physiolog0.98575805
75MP0009703_decreased_birth_body0.96425338
76MP0004957_abnormal_blastocyst_morpholog0.95543032
77MP0008057_abnormal_DNA_replication0.95269968
78MP0003787_abnormal_imprinting0.94282932
79MP0009697_abnormal_copulation0.94260803
80MP0002693_abnormal_pancreas_physiology0.94133855
81MP0006276_abnormal_autonomic_nervous0.93559545
82MP0004133_heterotaxia0.92063988
83MP0002163_abnormal_gland_morphology0.91801126
84MP0005023_abnormal_wound_healing0.90557066
85MP0003567_abnormal_fetal_cardiomyocyte0.90369712
86MP0001270_distended_abdomen0.89439571
87MP0003786_premature_aging0.87391651
88MP0005220_abnormal_exocrine_pancreas0.82954412
89MP0003718_maternal_effect0.82315600
90MP0000015_abnormal_ear_pigmentation0.82157648
91MP0000566_synostosis0.81672498
92MP0010094_abnormal_chromosome_stability0.81593420
93MP0001784_abnormal_fluid_regulation0.81198385
94MP0005508_abnormal_skeleton_morphology0.80288778
95MP0003045_fibrosis0.80135188
96MP0001299_abnormal_eye_distance/0.80019176
97MP0004043_abnormal_pH_regulation0.79853430
98MP0001765_abnormal_ion_homeostasis0.79823479
99MP0000678_abnormal_parathyroid_gland0.78709607
100MP0000613_abnormal_salivary_gland0.77752965
101MP0005647_abnormal_sex_gland0.77051262
102MP0005645_abnormal_hypothalamus_physiol0.76863225
103MP0002736_abnormal_nociception_after0.76506357
104MP0003115_abnormal_respiratory_system0.75702101
105MP0001958_emphysema0.75652104
106MP0001545_abnormal_hematopoietic_system0.74866583
107MP0005397_hematopoietic_system_phenotyp0.74866583
108MP0005375_adipose_tissue_phenotype0.74414941
109MP0003186_abnormal_redox_activity0.73927948
110MP0010307_abnormal_tumor_latency0.73060905
111MP0005174_abnormal_tail_pigmentation0.71091654
112MP0000367_abnormal_coat/_hair0.70952297
113MP0000372_irregular_coat_pigmentation0.70348136
114MP0004197_abnormal_fetal_growth/weight/0.70013645
115MP0001756_abnormal_urination0.69781842
116MP0001968_abnormal_touch/_nociception0.69156354
117MP0000428_abnormal_craniofacial_morphol0.68834158
118MP0003111_abnormal_nucleus_morphology0.67853891
119MP0001730_embryonic_growth_arrest0.67168048
120MP0002282_abnormal_trachea_morphology0.65239552
121MP0002876_abnormal_thyroid_physiology0.64921580
122MP0008260_abnormal_autophagy0.64539007
123MP0002295_abnormal_pulmonary_circulatio0.62279212
124MP0001919_abnormal_reproductive_system0.61622429
125MP0002751_abnormal_autonomic_nervous0.61139724
126MP0003119_abnormal_digestive_system0.60086534
127MP0000465_gastrointestinal_hemorrhage0.59918692
128MP0003698_abnormal_male_reproductive0.59672595
129MP0000627_abnormal_mammary_gland0.59302362
130MP0002086_abnormal_extraembryonic_tissu0.59123593
131MP0005379_endocrine/exocrine_gland_phen0.58282927
132MP0004381_abnormal_hair_follicle0.57748428
133MP0001697_abnormal_embryo_size0.57540028
134MP0002088_abnormal_embryonic_growth/wei0.57382445
135MP0000534_abnormal_ureter_morphology0.57175513
136MP0003984_embryonic_growth_retardation0.56981283
137MP0002210_abnormal_sex_determination0.56803646
138MP0003123_paternal_imprinting0.56795554
139MP0008961_abnormal_basal_metabolism0.55311476
140MP0008775_abnormal_heart_ventricle0.55224366
141MP0008770_decreased_survivor_rate0.55145871
142MP0001440_abnormal_grooming_behavior0.54891184
143MP0000163_abnormal_cartilage_morphology0.54828532
144MP0003943_abnormal_hepatobiliary_system0.54799909
145MP0001672_abnormal_embryogenesis/_devel0.54381631
146MP0005380_embryogenesis_phenotype0.54381631
147MP0003121_genomic_imprinting0.54269357
148MP0003077_abnormal_cell_cycle0.53873730
149MP0000631_abnormal_neuroendocrine_gland0.53461383
150MP0003937_abnormal_limbs/digits/tail_de0.53194312
151MP0004742_abnormal_vestibular_system0.52960673
152MP0008789_abnormal_olfactory_epithelium0.52883890
153MP0001340_abnormal_eyelid_morphology0.52511627
154MP0002111_abnormal_tail_morphology0.51797954
155MP0005257_abnormal_intraocular_pressure0.51688565
156MP0005248_abnormal_Harderian_gland0.51611508
157MP0003950_abnormal_plasma_membrane0.51573308
158MP0009672_abnormal_birth_weight0.51517730
159MP0009384_cardiac_valve_regurgitation0.51123262
160MP0002697_abnormal_eye_size0.51077233
161MP0002080_prenatal_lethality0.50797720
162MP0002084_abnormal_developmental_patter0.49973391
163MP0002085_abnormal_embryonic_tissue0.48785711
164MP0000432_abnormal_head_morphology0.48646975

Predicted human phenotypes

RankGene SetZ-score
1Poikilocytosis (HP:0004447)8.50462962
2Abnormality of the heme biosynthetic pathway (HP:0010472)7.34348150
3Acanthocytosis (HP:0001927)5.97290597
4Reticulocytosis (HP:0001923)5.42371621
5Hypochromic microcytic anemia (HP:0004840)5.12846133
6Onycholysis (HP:0001806)5.09783912
7Diaphragmatic weakness (HP:0009113)4.65077241
8Osteomalacia (HP:0002749)4.60452597
9Abnormal hemoglobin (HP:0011902)4.30161481
10Cholelithiasis (HP:0001081)4.22120784
11Fragile nails (HP:0001808)4.09844423
12Abnormal gallbladder morphology (HP:0012437)4.06560457
13Pili torti (HP:0003777)3.90608034
14Biliary tract neoplasm (HP:0100574)3.73494299
15Insomnia (HP:0100785)3.68057233
16Woolly hair (HP:0002224)3.66507803
17Ependymoma (HP:0002888)3.65596302
18Paralysis (HP:0003470)3.62447800
19Milia (HP:0001056)3.55183967
20Atrophic scars (HP:0001075)3.54214454
21Abnormality of reticulocytes (HP:0004312)3.37086253
22Right ventricular cardiomyopathy (HP:0011663)3.22911905
23Abnormality of the fingertips (HP:0001211)3.22544177
24Ileus (HP:0002595)3.18045499
25Hypotrichosis (HP:0001006)3.10070489
26Plantar hyperkeratosis (HP:0007556)3.09722917
27Abnormal blistering of the skin (HP:0008066)3.05827784
28Hyperbilirubinemia (HP:0002904)2.99890952
29Fragile skin (HP:0001030)2.98208737
30Abnormality of nail color (HP:0100643)2.97930770
31Premature rupture of membranes (HP:0001788)2.97807685
32Abnormality of the gallbladder (HP:0005264)2.82957178
33Chronic bronchitis (HP:0004469)2.70084894
34Homocystinuria (HP:0002156)2.68678145
35Abnormality of homocysteine metabolism (HP:0010919)2.68678145
36Hypochromic anemia (HP:0001931)2.65273836
37Erythema (HP:0010783)2.63252155
38Astrocytoma (HP:0009592)2.59758537
39Abnormality of the astrocytes (HP:0100707)2.59758537
40Increased IgE level (HP:0003212)2.58690065
41Abnormality of the salivary glands (HP:0010286)2.54231545
42Abnormal biliary tract morphology (HP:0012440)2.49870578
43Neoplasm of the liver (HP:0002896)2.44788965
44Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.44539020
45Abnormality of the labia minora (HP:0012880)2.42266356
46Malignant gastrointestinal tract tumors (HP:0006749)2.34851739
47Gastrointestinal carcinoma (HP:0002672)2.34851739
48Abnormal hair laboratory examination (HP:0003328)2.29584836
49Abnormality of chloride homeostasis (HP:0011422)2.28989459
50Congenital ichthyosiform erythroderma (HP:0007431)2.25667674
51Hypoplastic labia majora (HP:0000059)2.23954933
52Neoplasm of the oral cavity (HP:0100649)2.21632222
53Cholecystitis (HP:0001082)2.20746498
54Abnormal gallbladder physiology (HP:0012438)2.20746498
55Palmoplantar hyperkeratosis (HP:0000972)2.20505711
56Curly hair (HP:0002212)2.17337316
57Toxemia of pregnancy (HP:0100603)2.16858743
58Glioma (HP:0009733)2.15758975
59Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.13757289
60Breast carcinoma (HP:0003002)2.13049889
61Hyperparathyroidism (HP:0000843)2.11435184
62Duplicated collecting system (HP:0000081)2.09614551
63Agnosia (HP:0010524)2.09519753
64Hyporeflexia of lower limbs (HP:0002600)2.08353848
65Polycythemia (HP:0001901)2.07382093
66Neoplasm of the small intestine (HP:0100833)2.06746299
67Microcytic anemia (HP:0001935)2.04659525
68Rhabdomyosarcoma (HP:0002859)2.01863245
69Lip pit (HP:0100267)2.01575496
70Palmar hyperkeratosis (HP:0010765)1.99502020
71Birth length less than 3rd percentile (HP:0003561)1.97507979
72Nail dystrophy (HP:0008404)1.96703846
73Uterine neoplasm (HP:0010784)1.95032141
74Aplasia involving bones of the extremities (HP:0009825)1.94916684
75Aplasia involving bones of the upper limbs (HP:0009823)1.94916684
76Aplasia of the phalanges of the hand (HP:0009802)1.94916684
77Amelogenesis imperfecta (HP:0000705)1.94780809
78Abnormality of the labia majora (HP:0012881)1.94593419
79Hyperinsulinemic hypoglycemia (HP:0000825)1.94046899
80Neoplasm of the rectum (HP:0100743)1.91382097
81Natal tooth (HP:0000695)1.90046574
82Neoplasm of the respiratory system (HP:0100606)1.89889955
83Bronchomalacia (HP:0002780)1.89252974
84Neonatal short-limb short stature (HP:0008921)1.88919451
85Protruding tongue (HP:0010808)1.87451997
86Abnormality of the gastric mucosa (HP:0004295)1.86115765
87Cerebral aneurysm (HP:0004944)1.84840080
88Shallow orbits (HP:0000586)1.81506510
89Abnormality of the renal collecting system (HP:0004742)1.81285265
90Depressed nasal tip (HP:0000437)1.81277964
91Pustule (HP:0200039)1.81053025
92Mildly elevated creatine phosphokinase (HP:0008180)1.81039204
93Abnormality of transition element cation homeostasis (HP:0011030)1.80111340
94Aortic aneurysm (HP:0004942)1.79480472
95Protrusio acetabuli (HP:0003179)1.79215798
96Insulin-resistant diabetes mellitus (HP:0000831)1.79181319
97Hyponatremia (HP:0002902)1.78799754
98Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.75143047
99Labial hypoplasia (HP:0000066)1.75142904
100Pallor (HP:0000980)1.74687373
101Unilateral renal agenesis (HP:0000122)1.73619335
102Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.73579627
103Abnormal hair whorl (HP:0010721)1.73024707
104Cutaneous photosensitivity (HP:0000992)1.72897570
105Freckling (HP:0001480)1.71098791
106Hypoplasia of dental enamel (HP:0006297)1.70819728
107Hypoplastic female external genitalia (HP:0012815)1.70781034
108Acanthosis nigricans (HP:0000956)1.70488841
109Symptomatic seizures (HP:0011145)1.69352262
110Short nail (HP:0001799)1.69024704
111Lower limb amyotrophy (HP:0007210)1.68887097
112Interstitial pulmonary disease (HP:0006530)1.67502437
113Germ cell neoplasia (HP:0100728)1.65632502
114Abnormality of the distal phalanges of the toes (HP:0010182)1.65474251
115Abnormality of sodium homeostasis (HP:0010931)1.65417992
116Nausea (HP:0002018)1.65328933
117Severe visual impairment (HP:0001141)1.63912562
118Medulloblastoma (HP:0002885)1.63537656
119Down-sloping shoulders (HP:0200021)1.62821140
120Dysdiadochokinesis (HP:0002075)1.62653298
121Hypoglycemic seizures (HP:0002173)1.61320366
122Abnormality of iron homeostasis (HP:0011031)1.61247732
123Spinal cord compression (HP:0002176)1.61189413
124Advanced eruption of teeth (HP:0006288)1.60964578
125Pendular nystagmus (HP:0012043)1.59681810
126Follicular hyperkeratosis (HP:0007502)1.59558564
127Abnormality of the aortic arch (HP:0012303)1.58370070
128Cerebral palsy (HP:0100021)1.58246289
129Chromosomal breakage induced by crosslinking agents (HP:0003221)1.57673969
130Ulnar bowing (HP:0003031)1.56753222
131Ectropion (HP:0000656)1.56334987
132Thin skin (HP:0000963)1.56319130
133Increased connective tissue (HP:0009025)1.55804499
134Abnormal vertebral ossification (HP:0100569)1.55078371
135Exocrine pancreatic insufficiency (HP:0001738)1.51159687
136Impulsivity (HP:0100710)1.50991644
137Abnormal number of erythroid precursors (HP:0012131)1.50439244
138Neoplasm of striated muscle (HP:0009728)1.50310056
139Anhidrosis (HP:0000970)1.50051042
140Confusion (HP:0001289)1.49312005
141Dilatation of the ascending aorta (HP:0005111)1.49269784
142Hyperkalemia (HP:0002153)1.48405172
143Distal lower limb muscle weakness (HP:0009053)1.48331933
144Pterygium (HP:0001059)1.48149822
145Spinal rigidity (HP:0003306)1.47199932
146Tibial bowing (HP:0002982)1.46729875
147Distal lower limb amyotrophy (HP:0008944)1.46680194
148Pancreatic islet-cell hyperplasia (HP:0004510)1.46414266
149Aneurysm (HP:0002617)1.46324711
150Hepatocellular carcinoma (HP:0001402)1.46157301
151Alopecia of scalp (HP:0002293)1.45104157
152Missing ribs (HP:0000921)1.44954612
153Hyperglycemia (HP:0003074)1.44318642
154Laryngomalacia (HP:0001601)1.44270207
155Abnormality of the dental root (HP:0006486)1.41439812
156Taurodontia (HP:0000679)1.41439812
157Abnormality of permanent molar morphology (HP:0011071)1.41439812
158Colon cancer (HP:0003003)1.41147698
159Ectopic kidney (HP:0000086)1.41077069
160Genetic anticipation (HP:0003743)1.41012758
161Albinism (HP:0001022)1.40585033
162Aplasia/Hypoplasia of the earlobes (HP:0009906)1.40432627
163Clumsiness (HP:0002312)1.40333992
164Abnormality of the pons (HP:0007361)1.39112759
165Abnormality of cells of the erythroid lineage (HP:0012130)1.39040629
166Neoplasm of the colon (HP:0100273)1.38690713
167Thyroid carcinoma (HP:0002890)1.38202500

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK33.67886007
2TLK12.86748331
3MAPKAPK32.55655973
4TRIB32.46486324
5EEF2K2.45760141
6MAP3K22.42531905
7TESK12.37823864
8CDK122.30951632
9CAMK1G2.15297349
10ZAK2.10929353
11EIF2AK12.10156270
12MAP2K22.06251499
13FER1.99319855
14DYRK21.95630446
15PRKD31.91906114
16PASK1.88522052
17ERN11.86759077
18STK41.86331039
19MKNK21.81485974
20MST41.80535156
21ACVR1B1.79692470
22TRPM71.78401170
23MAP3K31.78192179
24DYRK1B1.75558669
25EPHA21.74549692
26PLK31.73702238
27MAPKAPK51.72927541
28RIPK11.72623470
29MAP4K21.71335735
30HIPK21.65621206
31CASK1.62669171
32EPHB11.56447659
33SGK21.55121320
34DYRK31.51228986
35PTK61.50715311
36LATS11.49227844
37TNIK1.48745824
38INSRR1.43550238
39PTK21.42823192
40RPS6KB21.38410874
41STK101.37061581
42AKT31.34062455
43MAPK151.31037507
44TTK1.28441598
45CLK11.28128891
46EPHB21.27998431
47CDC71.27818721
48PBK1.26916544
49SIK11.25892015
50RPS6KA51.25538141
51CDK61.24905695
52TAOK11.24578549
53TAOK21.24304498
54NME11.21288516
55WNK41.19773010
56MET1.19430236
57PDGFRA1.18098435
58ERBB21.16754573
59SGK31.15798495
60TAF11.14839970
61WNK31.13522473
62BMX1.12784038
63STK38L1.10475912
64FRK1.10391821
65PLK11.08546798
66MAP3K11.08015444
67MAP2K11.07865803
68SGK2231.07382221
69SGK4941.07382221
70OXSR11.06670616
71STK31.05935322
72ICK1.02819587
73CDC42BPA1.02348514
74MKNK11.01708717
75SCYL21.01041438
76PKN21.00678407
77STK110.98738791
78LRRK20.97990665
79MAP3K80.97584500
80BRSK10.97448077
81STK240.97331959
82PAK30.94231443
83DAPK20.92332959
84EPHA30.91342104
85TSSK60.90228947
86MAP3K100.88673977
87MAP3K110.88358920
88SGK10.88342045
89MST1R0.84824936
90CDK90.82167884
91RPS6KA20.81999352
92TRIM280.80210468
93PRPF4B0.79783571
94AURKB0.78437020
95GRK10.76437061
96MTOR0.75697552
97RET0.74195973
98PRKAA20.73435548
99TTN0.73321410
100FGFR20.71823488
101MAPKAPK20.66764571
102RPS6KA60.66420794
103AURKA0.64710935
104PDK30.63811666
105PDK40.63811666
106MAP3K40.63737638
107PTK2B0.62903818
108PRKAA10.62233432
109MELK0.61961366
110SRPK10.61393985
111NLK0.61374016
112PAK20.60469078
113PDGFRB0.60038096
114ATM0.59084197
115PLK40.59041651
116PRKD10.58158954
117GRK60.57673740
118PRKCZ0.57195757
119BCR0.56823892
120PIM10.56228157
121WNK10.54539345
122PDK20.53706111
123BRSK20.53161802
124DDR20.52339057
125CAMK40.50178912
126DYRK1A0.50050422
127MAPK110.49836365
128CSNK1D0.49653035
129RPS6KA10.48822967
130GSK3A0.48310857
131AKT10.48164175
132MAP3K50.47949131
133TGFBR20.47656794
134CHEK10.47200462
135YES10.46052555
136LMTK20.45586755
137BRD40.44245439
138ILK0.43461027
139STK390.43260332
140JAK20.43233094
141CHEK20.42590412
142GSK3B0.42508808
143MAPK90.41810481
144CAMK1D0.41606869
145MAP2K30.40558666
146PRKCH0.40333805
147IKBKB0.39918303
148BMPR1B0.39547991
149MAPK140.37459922
150BUB10.37119646
151NTRK10.36990543
152MAP3K60.36842150
153PRKD20.36666380
154CSNK1A10.36221600
155PAK40.35904748
156PRKCI0.35328587
157PDPK10.35168633
158RPS6KL10.35017483
159RPS6KC10.35017483
160CHUK0.34839135
161NEK20.33388403

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053224.62937022
2Maturity onset diabetes of the young_Homo sapiens_hsa049504.04891304
3Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008604.03837138
4Alcoholism_Homo sapiens_hsa050343.08089288
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.88615048
6Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.56219960
7Bladder cancer_Homo sapiens_hsa052192.40891314
8Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.39117561
9Nitrogen metabolism_Homo sapiens_hsa009102.29510288
10Sulfur metabolism_Homo sapiens_hsa009202.09645139
11Vitamin B6 metabolism_Homo sapiens_hsa007502.03672262
12Regulation of autophagy_Homo sapiens_hsa041402.02666437
13Mismatch repair_Homo sapiens_hsa034301.96094209
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.94898634
15ECM-receptor interaction_Homo sapiens_hsa045121.77789051
16Basal transcription factors_Homo sapiens_hsa030221.70680408
17Phototransduction_Homo sapiens_hsa047441.63634745
18Viral carcinogenesis_Homo sapiens_hsa052031.53779577
19Non-homologous end-joining_Homo sapiens_hsa034501.50491098
20Chronic myeloid leukemia_Homo sapiens_hsa052201.48239379
21Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.47750521
22Collecting duct acid secretion_Homo sapiens_hsa049661.40183005
23Dorso-ventral axis formation_Homo sapiens_hsa043201.38453866
24Carbohydrate digestion and absorption_Homo sapiens_hsa049731.36774412
25Protein export_Homo sapiens_hsa030601.35801682
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.31231005
27ABC transporters_Homo sapiens_hsa020101.31207010
28Small cell lung cancer_Homo sapiens_hsa052221.30414613
29Ovarian steroidogenesis_Homo sapiens_hsa049131.28730069
30Adherens junction_Homo sapiens_hsa045201.26302663
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.24365326
32Prostate cancer_Homo sapiens_hsa052151.23116571
33RNA polymerase_Homo sapiens_hsa030201.22761310
34Tight junction_Homo sapiens_hsa045301.21958801
35Linoleic acid metabolism_Homo sapiens_hsa005911.19842727
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.17737857
37One carbon pool by folate_Homo sapiens_hsa006701.17261705
38Vitamin digestion and absorption_Homo sapiens_hsa049771.16212879
39Fanconi anemia pathway_Homo sapiens_hsa034601.13819596
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.12526829
41Nicotine addiction_Homo sapiens_hsa050331.11860431
42Focal adhesion_Homo sapiens_hsa045101.09428388
43Steroid biosynthesis_Homo sapiens_hsa001001.08937782
44Taste transduction_Homo sapiens_hsa047421.07989183
45Protein digestion and absorption_Homo sapiens_hsa049741.07804197
46Mineral absorption_Homo sapiens_hsa049781.06588147
47Proteoglycans in cancer_Homo sapiens_hsa052051.06463892
48mRNA surveillance pathway_Homo sapiens_hsa030151.06080026
49Insulin secretion_Homo sapiens_hsa049111.05660215
50Type II diabetes mellitus_Homo sapiens_hsa049301.05658102
51Non-small cell lung cancer_Homo sapiens_hsa052231.04890348
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04799782
53p53 signaling pathway_Homo sapiens_hsa041151.02569396
54Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.00726095
55Hippo signaling pathway_Homo sapiens_hsa043901.00048377
56Homologous recombination_Homo sapiens_hsa034400.94807448
57Pancreatic cancer_Homo sapiens_hsa052120.94603954
58Insulin resistance_Homo sapiens_hsa049310.93910887
59Glioma_Homo sapiens_hsa052140.93323524
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.92969812
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91412166
62Lysine degradation_Homo sapiens_hsa003100.91216831
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90825628
64Circadian rhythm_Homo sapiens_hsa047100.90598921
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88861052
66MicroRNAs in cancer_Homo sapiens_hsa052060.88441909
67Malaria_Homo sapiens_hsa051440.88431306
68Prolactin signaling pathway_Homo sapiens_hsa049170.87628373
69Renal cell carcinoma_Homo sapiens_hsa052110.85522668
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.85147667
71Estrogen signaling pathway_Homo sapiens_hsa049150.83273122
72Vibrio cholerae infection_Homo sapiens_hsa051100.82777932
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82273644
74Tryptophan metabolism_Homo sapiens_hsa003800.80970691
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80484007
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.80355559
77African trypanosomiasis_Homo sapiens_hsa051430.80259644
78RNA transport_Homo sapiens_hsa030130.80159786
79Thyroid cancer_Homo sapiens_hsa052160.79887496
80Endometrial cancer_Homo sapiens_hsa052130.78647504
81Pancreatic secretion_Homo sapiens_hsa049720.78303375
82Melanoma_Homo sapiens_hsa052180.77997762
83AMPK signaling pathway_Homo sapiens_hsa041520.77355101
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77285766
85Amoebiasis_Homo sapiens_hsa051460.76912134
86Sphingolipid metabolism_Homo sapiens_hsa006000.76332360
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75858977
88Cell cycle_Homo sapiens_hsa041100.75280004
89Long-term depression_Homo sapiens_hsa047300.74609866
90Basal cell carcinoma_Homo sapiens_hsa052170.73699525
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72852987
92Selenocompound metabolism_Homo sapiens_hsa004500.72204512
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.72106991
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.71806805
95Spliceosome_Homo sapiens_hsa030400.71078688
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70917210
97Hedgehog signaling pathway_Homo sapiens_hsa043400.70583992
98Oocyte meiosis_Homo sapiens_hsa041140.70357678
99Ether lipid metabolism_Homo sapiens_hsa005650.69860873
100Endocytosis_Homo sapiens_hsa041440.69124187
101Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68874498
102Apoptosis_Homo sapiens_hsa042100.68601221
103Thyroid hormone synthesis_Homo sapiens_hsa049180.66958528
104Fat digestion and absorption_Homo sapiens_hsa049750.66090227
105DNA replication_Homo sapiens_hsa030300.65428046
106VEGF signaling pathway_Homo sapiens_hsa043700.65383066
107RNA degradation_Homo sapiens_hsa030180.63574592
108Hematopoietic cell lineage_Homo sapiens_hsa046400.62189700
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62149879
110Platelet activation_Homo sapiens_hsa046110.60107135
111Steroid hormone biosynthesis_Homo sapiens_hsa001400.60044165
112Fatty acid biosynthesis_Homo sapiens_hsa000610.59782811
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58588377
114TGF-beta signaling pathway_Homo sapiens_hsa043500.58337019
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58016425
116Serotonergic synapse_Homo sapiens_hsa047260.57997946
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.57901944
118FoxO signaling pathway_Homo sapiens_hsa040680.56768593
119Glucagon signaling pathway_Homo sapiens_hsa049220.56150637
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.55794092
121Base excision repair_Homo sapiens_hsa034100.54510960
122Butanoate metabolism_Homo sapiens_hsa006500.53788986
123Melanogenesis_Homo sapiens_hsa049160.53368033
124Metabolic pathways_Homo sapiens_hsa011000.51407049
125Arachidonic acid metabolism_Homo sapiens_hsa005900.50928382
126AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50609410
127Toxoplasmosis_Homo sapiens_hsa051450.50126023
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.50018717
129Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49868510
130Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49421242
131Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48254721
132HTLV-I infection_Homo sapiens_hsa051660.47935609
133Hepatitis B_Homo sapiens_hsa051610.47500423
134Glycerolipid metabolism_Homo sapiens_hsa005610.46739488
135Inositol phosphate metabolism_Homo sapiens_hsa005620.45505395
136Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45321295
137Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44434603
138Acute myeloid leukemia_Homo sapiens_hsa052210.44254682
139Gap junction_Homo sapiens_hsa045400.44066336
140Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44047126
141Pathways in cancer_Homo sapiens_hsa052000.43991483
142Central carbon metabolism in cancer_Homo sapiens_hsa052300.42721247
143Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42679907
144Insulin signaling pathway_Homo sapiens_hsa049100.42594851
145Hepatitis C_Homo sapiens_hsa051600.42399189
146Arginine biosynthesis_Homo sapiens_hsa002200.42064633
147mTOR signaling pathway_Homo sapiens_hsa041500.39995040
148Wnt signaling pathway_Homo sapiens_hsa043100.39520160
149Cocaine addiction_Homo sapiens_hsa050300.38262024
150Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38205830
151Nucleotide excision repair_Homo sapiens_hsa034200.38125566
152Glycerophospholipid metabolism_Homo sapiens_hsa005640.37687349
153Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34339928
154Pyrimidine metabolism_Homo sapiens_hsa002400.33261243
155Purine metabolism_Homo sapiens_hsa002300.32817534
156Jak-STAT signaling pathway_Homo sapiens_hsa046300.32375642
157Axon guidance_Homo sapiens_hsa043600.31346683

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